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Séverine Denoyelle

31
Documents

Publications

Role of symmetry in 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as inhibitors of translation initiation

Hongwei Yang , Ting Chen , Séverine Denoyelle , Limo Chen , Jing Fan
Bioorganic and Medicinal Chemistry Letters, 2023, 80, pp.129119. ⟨10.1016/j.bmcl.2022.129119⟩
Article dans une revue hal-04119175v1
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Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy

Brigida Boccanegra , Ornella Cappellari , Paola Mantuano , Daniela Trisciuzzi , Antonietta Mele
Frontiers in Immunology, 2023, 14, pp.1119888. ⟨10.3389/fimmu.2023.1119888⟩
Article dans une revue hal-04121024v1

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

Gimena Fernandez , Agustina Cabral , Pablo de Francesco , Maia Uriarte , Mirta Reynaldo
Cellular and Molecular Life Sciences, 2022, 79 (5), pp.277. ⟨10.1007/s00018-022-04302-5⟩
Article dans une revue hal-04044157v1

A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin

Lucie Holá , Blanka Železná , Alena Karnošová , Jaroslav Kuneš , Jean-Alain Fehrentz
Journal of Pharmacology and Experimental Therapeutics, 2022, 383 (2), pp.129-136. ⟨10.1124/jpet.122.001322⟩
Article dans une revue hal-04119343v1
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Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin

Sylvie Péraldi-Roux , Morgane Bayle , Céline M'Kadmi , Marjorie Damian , Justine Vaillé
Biochemical Pharmacology, 2022, 202, ⟨10.1016/j.bcp.2022.115114⟩
Article dans une revue hal-03813988v1
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LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

Emilio Mustafá , Santiago Cordisco González , Marjorie Damian , Sonia Cantel , Severine Denoyelle
Frontiers in Pharmacology, 2021, 12, pp.712437. ⟨10.3389/fphar.2021.712437⟩
Article dans une revue hal-03382623v1

Allosteric modulation of ghrelin receptor signaling by lipids

Marjorie Damian , Maxime Louet , Antoniel Augusto Severo Gomes , Céline M’kadmi , Séverine Denoyelle
Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩
Article dans une revue hal-03852471v1
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Allosteric modulation of ghrelin receptor signaling by lipids

Marjorie Damian , Maxime Louet , Antoniel Augusto Severo Gomes , Céline M’kadmi , Séverine Denoyelle
Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩
Article dans une revue hal-03407522v1
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Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

Maxime Louet , Marina Casiraghi , Marjorie Damian , Mauricio Gs Costa , Pedro Renault
eLife, 2021, 10, ⟨10.7554/elife.63201⟩
Article dans une revue hal-03407524v1
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Development of non-peptidic inverse agonists of the ghrelin receptor (GHSR) based on the 1,2,4-triazole scaffold

Khoubaib Ben Haj Salah , Mathieu Maingot , Anne-Laure Blayo , Céline M'Kadmi , Marjorie Damian
Journal of Medicinal Chemistry, 2020, 63 (19), pp.10796-10815. ⟨10.1021/acs.jmedchem.9b02122⟩
Article dans une revue hal-03027489v1
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Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region

Franco Barrile , Céline M'Kadmi , Pablo de Francesco , Agustina Cabral , Guadalupe García Romero
Molecular and Cellular Endocrinology, 2019, 498, pp.110573. ⟨10.1016/j.mce.2019.110573⟩
Article dans une revue hal-02375522v1
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Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials

Olivier Berger , Stéphanie Ortial , Sharon Wein , Séverine Denoyelle , Françoise Bressolle
Bioorganic and Medicinal Chemistry Letters, 2019, 29, pp.2203 - 2207. ⟨10.1016/j.bmcl.2019.06.045⟩
Article dans une revue hal-03488325v1

N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor

Céline M'Kadmi , Agustina Cabral , Franco Barrile , Julien Giribaldi , Sonia Cantel
Journal of Medicinal Chemistry, 2019, 62 (2), pp.965-973. ⟨10.1021/acs.jmedchem.8b01644⟩
Article dans une revue hal-02307053v1

Synthesis of [1,2,4]Triazolo[4,3- a ]piperazin-6-ones: An Approach to the Triazole-Fused Ketopiperazine Scaffold

Khoubaib Ben Haj Salah , Baptiste Legrand , Mathieu Bibian , Emmanuel Wenger , Jean-Alain Fehrentz
Organic Letters, 2018, 20 (11), pp.3250-3254. ⟨10.1021/acs.orglett.8b01112⟩
Article dans une revue hal-02871181v1

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

Marjorie Damian , Véronique Pons , Pedro Renault , Céline M’kadmi , Bartholomé Delort
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (17), pp.4501-4506. ⟨10.1073/pnas.1712725115⟩
Article dans une revue hal-02322168v1

New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center

Mathieu Maingot , Anne-Laure Blayo , Severine Denoyelle , Céline M’kadmi , Marjorie Damian
Bioorganic and Medicinal Chemistry Letters, 2016, 26 (10), pp.2408-2412. ⟨10.1016/j.bmcl.2016.04.003⟩
Article dans une revue hal-02871896v1

Synthesis of Thieno[3,2- e ][1,4]diazepin-2-ones: Application of an Uncatalysed Pictet-Spengler Reaction

Séverine Denoyelle , Guillaume Tambutet , Nicolas Masurier , Ludovic Maillard , Jean Martinez
European Journal of Organic Chemistry, 2015, 2015 (32), pp.7146-7153. ⟨10.1002/ejoc.201500943⟩
Article dans une revue hal-03563932v1

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.

Marjorie Damian , Sophie Mary , Mathieu Maingot , Céline M'Kadmi , Didier Gagne
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (5), pp.1601-1606. ⟨10.1073/pnas.1414618112⟩
Article dans une revue hal-01115392v1

New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.

Anne-Laure Blayo , Mathieu Maingot , Babette Aicher , Céline M'Kadmi , Peter Schmidt
Bioorganic and Medicinal Chemistry Letters, 2015, 25 (1), pp.20-24. ⟨10.1016/j.bmcl.2014.11.031⟩
Article dans une revue hal-01090274v1
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Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

Céline M'Kadmi , Jean-Philippe Leyris , Lauriane Onfroy , Céline Galés , Aude Saulière
Journal of Biological Chemistry, 2015, 290 (45), pp.27021-27039. ⟨10.1074/jbc.M115.659250⟩
Article dans une revue hal-03564155v1

The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist

Aline Moulin , Luc Brunel , Damien Boeglin , Luc Demange , Johanne Ryan
Amino Acids, 2013, 44 (2), pp.301-314. ⟨10.1007/s00726-012-1355-2⟩
Article dans une revue hal-02871938v1

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

Séverine Denoyelle , Ting Chen , Hongwei Yang , Limo Chen , Yingzhen Zhang
European Journal of Medicinal Chemistry, 2013, 69, pp.537-553. ⟨10.1016/j.ejmech.2013.08.030⟩
Article dans une revue hal-03562672v1

Selective C-Acylation of 2-Aminoimidazo[1,2- a ]pyridine: Application to the Synthesis of Imidazopyridine-Fused [1,3]Diazepinones

Nicolas Masurier , Roberta Aruta , Vincent Gaumet , Séverine Denoyelle , Emmanuel Moreau
Journal of Organic Chemistry, 2012, 77 (7), pp.3679 - 3685. ⟨10.1021/jo300364d⟩
Article dans une revue hal-01677551v1

In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents

Séverine Denoyelle , Ting Chen , Limo Chen , Yibo Wang , Edvin Klosi
Bioorganic and Medicinal Chemistry Letters, 2012, 22 (1), pp.402-409. ⟨10.1016/j.bmcl.2011.10.126⟩
Article dans une revue hal-04118217v1

Tumor suppression by small molecule inhibitors of translation initiation

Limo Chen , Bertal Aktas , Yibo Wang , Xiaoying He , Rupam Sahoo
Oncotarget, 2012, 3 (8), pp.869-881. ⟨10.18632/oncotarget.598⟩
Article dans une revue hal-04121321v1
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Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

Ting Chen , Duygu Ozel , Yuan Qiao , Fred Harbinski , Limo Chen
Nature Chemical Biology, 2011, 7 (9), pp.610-616. ⟨10.1038/nchembio.613⟩
Article dans une revue hal-04119403v1
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Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs

Stéphanie Ortial , Severine Denoyelle , Sharon Wein , Olivier Berger , Thierry Durand
ChemMedChem, 2010, 5 (1), pp.52-55. ⟨10.1002/cmdc.200900427⟩
Article dans une revue hal-00448020v1

A structure–activity investigation of hemifluorinated bifunctional bolaamphiphiles designed for gene delivery

Mélanie Brunelle , Ange Polidori , Séverine Denoyelle , Anne-Sylvie Fabiano , Pascal Vuillaume
Comptes Rendus. Chimie, 2009, 12 (1-2), pp.188-208. ⟨10.1016/j.crci.2008.05.018⟩
Article dans une revue hal-04119298v1

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents

Mahama Ouattara , Sharon Wein , Séverine Denoyelle , Stéphanie Ortial , Thierry Durand
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (3), pp.624-626. ⟨10.1016/j.bmcl.2008.12.058⟩
Article dans une revue hal-03530218v1

Synthesis and preliminary biological studies of hemifluorinated bifunctional bolaamphiphiles designed for gene delivery

Séverine Denoyelle , Ange Polidori , Mélanie Brunelle , Pascal Vuillaume , Sylvette Laurent
New Journal of Chemistry, 2006, 30 (4), pp.629. ⟨10.1039/b513944a⟩
Article dans une revue hal-04119479v1