Séverine Denoyelle

39
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Publications

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Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy

Brigida Boccanegra , Ornella Cappellari , Paola Mantuano , Daniela Trisciuzzi , Antonietta Mele et al.
Frontiers in Immunology, 2023, 14, pp.1119888. ⟨10.3389/fimmu.2023.1119888⟩
Article dans une revue hal-04121024 v1

Role of symmetry in 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as inhibitors of translation initiation

Hongwei Yang , Ting Chen , Séverine Denoyelle , Limo Chen , Jing Fan et al.
Bioorganic and Medicinal Chemistry Letters, 2023, 80, pp.129119. ⟨10.1016/j.bmcl.2022.129119⟩
Article dans une revue hal-04119175 v1
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GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

Gimena Fernandez , Agustina Cabral , Pablo Nicolás de Francesco , Maia Uriarte , Mirta Reynaldo et al.
Cellular and Molecular Life Sciences, 2022, 79 (5), pp.277. ⟨10.1007/s00018-022-04302-5⟩
Article dans une revue hal-04687046 v1
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Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin

Sylvie Péraldi-Roux , Morgane Bayle , Céline M'Kadmi , Marjorie Damian , Justine Vaillé et al.
Biochemical Pharmacology, 2022, 202, ⟨10.1016/j.bcp.2022.115114⟩
Article dans une revue hal-03813988 v1

A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin

Lucie Holá , Blanka Železná , Alena Karnošová , Jaroslav Kuneš , Jean-Alain Fehrentz et al.
Journal of Pharmacology and Experimental Therapeutics, 2022, 383 (2), pp.129-136. ⟨10.1124/jpet.122.001322⟩
Article dans une revue hal-04119343 v1
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Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

Maxime Louet , Marina Casiraghi , Marjorie Damian , Mauricio Gs Costa , Pedro Renault et al.
eLife, 2021, 10, pp.e63201. ⟨10.7554/elife.63201⟩
Article dans une revue hal-03407524 v1

Allosteric modulation of ghrelin receptor signaling by lipids

Marjorie Damian , Maxime Louet , Antoniel Augusto Severo Gomes , Céline M’kadmi , Séverine Denoyelle et al.
Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩
Article dans une revue hal-03852471 v1

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

Maia Uriarte , Pablo de Francesco , Gimena Fernández , Daniel Castrogiovanni , Micaela d'Arcangelo et al.
Molecular and Cellular Endocrinology, 2021, 538, pp.111449. ⟨10.1016/j.mce.2021.111449⟩
Article dans une revue hal-04614605 v1
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LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

Emilio Mustafá , Santiago Cordisco González , Marjorie Damian , Sonia Cantel , Severine Denoyelle et al.
Frontiers in Pharmacology, 2021, 12, pp.712437. ⟨10.3389/fphar.2021.712437⟩
Article dans une revue hal-03382623 v1
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Allosteric modulation of ghrelin receptor signaling by lipids

Marjorie Damian , Maxime Louet , Antoniel Augusto Severo Gomes , Céline M’kadmi , Séverine Denoyelle et al.
Nature Communications, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩
Article dans une revue hal-03407522 v1
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Development of non-peptidic inverse agonists of the ghrelin receptor (GHSR) based on the 1,2,4-triazole scaffold

Khoubaib Ben Haj Salah , Mathieu Maingot , Anne-Laure Blayo , Céline M'Kadmi , Marjorie Damian et al.
Journal of Medicinal Chemistry, 2020, 63 (19), pp.10796-10815. ⟨10.1021/acs.jmedchem.9b02122⟩
Article dans une revue hal-03027489 v1

N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor

Céline M'Kadmi , Agustina Cabral , Franco Barrile , Julien Giribaldi , Sonia Cantel et al.
Journal of Medicinal Chemistry, 2019, 62 (2), pp.965-973. ⟨10.1021/acs.jmedchem.8b01644⟩
Article dans une revue hal-02307053 v1
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Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials

Olivier Berger , Stéphanie Ortial , Sharon Wein , Séverine Denoyelle , Françoise Bressolle et al.
Bioorganic and Medicinal Chemistry Letters, 2019, 29, pp.2203 - 2207. ⟨10.1016/j.bmcl.2019.06.045⟩
Article dans une revue hal-03488325 v1
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Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region

Franco Barrile , Céline M'Kadmi , Pablo de Francesco , Agustina Cabral , Guadalupe García Romero et al.
Molecular and Cellular Endocrinology, 2019, 498, pp.110573. ⟨10.1016/j.mce.2019.110573⟩
Article dans une revue hal-02375522 v1

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

Marjorie Damian , Véronique Pons , Pedro Renault , Céline M’kadmi , Bartholomé Delort et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (17), pp.4501-4506. ⟨10.1073/pnas.1712725115⟩
Article dans une revue hal-02322168 v1

Synthesis of [1,2,4]Triazolo[4,3- a ]piperazin-6-ones: An Approach to the Triazole-Fused Ketopiperazine Scaffold

Khoubaib Ben Haj Salah , Baptiste Legrand , Mathieu Bibian , Emmanuel Wenger , Jean-Alain Fehrentz et al.
Organic Letters, 2018, 20 (11), pp.3250-3254. ⟨10.1021/acs.orglett.8b01112⟩
Article dans une revue hal-02871181 v1

New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center

Mathieu Maingot , Anne-Laure Blayo , Severine Denoyelle , Céline M’kadmi , Marjorie Damian et al.
Bioorganic and Medicinal Chemistry Letters, 2016, 26 (10), pp.2408-2412. ⟨10.1016/j.bmcl.2016.04.003⟩
Article dans une revue hal-02871896 v1
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Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

Céline M'Kadmi , Jean-Philippe Leyris , Lauriane Onfroy , Céline Galés , Aude Saulière et al.
Journal of Biological Chemistry, 2015, 290 (45), pp.27021-27039. ⟨10.1074/jbc.M115.659250⟩
Article dans une revue hal-03564155 v1

Synthesis of Thieno[3,2- e ][1,4]diazepin-2-ones: Application of an Uncatalysed Pictet-Spengler Reaction

Séverine Denoyelle , Guillaume Tambutet , Nicolas Masurier , Ludovic Maillard , Jean Martinez et al.
European Journal of Organic Chemistry, 2015, 2015 (32), pp.7146-7153. ⟨10.1002/ejoc.201500943⟩
Article dans une revue istex hal-03563932 v1

New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.

Anne-Laure Blayo , Mathieu Maingot , Babette Aicher , Céline M'Kadmi , Peter Schmidt et al.
Bioorganic and Medicinal Chemistry Letters, 2015, 25 (1), pp.20-24. ⟨10.1016/j.bmcl.2014.11.031⟩
Article dans une revue hal-01090274 v1

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

Séverine Denoyelle , Ting Chen , Hongwei Yang , Limo Chen , Yingzhen Zhang et al.
European Journal of Medicinal Chemistry, 2013, 69, pp.537-553. ⟨10.1016/j.ejmech.2013.08.030⟩
Article dans une revue istex hal-03562672 v1

The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist

Aline Moulin , Luc Brunel , Damien Boeglin , Luc Demange , Johanne Ryan et al.
Amino Acids, 2013, 44 (2), pp.301-314. ⟨10.1007/s00726-012-1355-2⟩
Article dans une revue istex hal-02871938 v1

In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents

Séverine Denoyelle , Ting Chen , Limo Chen , Yibo Wang , Edvin Klosi et al.
Bioorganic and Medicinal Chemistry Letters, 2012, 22 (1), pp.402-409. ⟨10.1016/j.bmcl.2011.10.126⟩
Article dans une revue hal-04118217 v1

Selective C-Acylation of 2-Aminoimidazo[1,2- a ]pyridine: Application to the Synthesis of Imidazopyridine-Fused [1,3]Diazepinones

Nicolas Masurier , Roberta Aruta , Vincent Gaumet , Séverine Denoyelle , Emmanuel Moreau et al.
Journal of Organic Chemistry, 2012, 77 (7), pp.3679 - 3685. ⟨10.1021/jo300364d⟩
Article dans une revue hal-01677551 v1

Tumor suppression by small molecule inhibitors of translation initiation

Limo Chen , Bertal Aktas , Yibo Wang , Xiaoying He , Rupam Sahoo et al.
Oncotarget, 2012, 3 (8), pp.869-881. ⟨10.18632/oncotarget.598⟩
Article dans une revue hal-04121321 v1
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Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

Ting Chen , Duygu Ozel , Yuan Qiao , Fred Harbinski , Limo Chen et al.
Nature Chemical Biology, 2011, 7 (9), pp.610-616. ⟨10.1038/nchembio.613⟩
Article dans une revue hal-04119403 v1
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Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs

Stéphanie Ortial , Severine Denoyelle , Sharon Wein , Olivier Berger , Thierry Durand et al.
ChemMedChem, 2010, 5 (1), pp.52-55. ⟨10.1002/cmdc.200900427⟩
Article dans une revue hal-00448020 v1

A structure–activity investigation of hemifluorinated bifunctional bolaamphiphiles designed for gene delivery

Mélanie Brunelle , Ange Polidori , Séverine Denoyelle , Anne-Sylvie Fabiano , Pascal Vuillaume et al.
Comptes Rendus. Chimie, 2009, 12 (1-2), pp.188-208. ⟨10.1016/j.crci.2008.05.018⟩
Article dans une revue istex hal-04119298 v1

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents

Mahama Ouattara , Sharon Wein , Séverine Denoyelle , Stéphanie Ortial , Thierry Durand et al.
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (3), pp.624-626. ⟨10.1016/j.bmcl.2008.12.058⟩
Article dans une revue istex hal-03530218 v1

Synthesis and preliminary biological studies of hemifluorinated bifunctional bolaamphiphiles designed for gene delivery

Séverine Denoyelle , Ange Polidori , Mélanie Brunelle , Pascal Vuillaume , Sylvette Laurent et al.
New Journal of Chemistry, 2006, 30 (4), pp.629. ⟨10.1039/b513944a⟩
Article dans une revue istex hal-04119479 v1

Development of potent GHSR inverse agonists: promising compounds for the treatment of obesity-related metabolic disorders

Khoubaib Ben Haj Salah , Célia Bouacha , Céline M'Kadmi , Jérémie Neasta , Catherine Oiry et al.
24th Tetrahedron Symposium, Elsevier, Jun 2024, Montpellier, France
Communication dans un congrès hal-04806641 v1

La fluorescence au service de la santé : suivi in vitro et in vivo de molécules bioactives impliquées dans la prise alimentaire: Le Récepteur de la Ghréline

Sonia Cantel , Séverine Denoyelle , Mario Perello , Jean‐louis Baneres , Jean-Alain Fehrentz
UTT de Montpellier, Jan 2024, Montpellier, France
Communication dans un congrès hal-04892225 v1

Growth hormone secretagogues exert anti-fibrotic actions in duchenne muscular dystrophy: a preclinical study

Ornella Cappellari , Paola Mantuano , Brigida Boccanegra , Santa Cirmi , Elena Bresciani et al.
56th Annual Scientific Meeting of the European Society for Clinical Investigation (56th ESCI Annual Scientific Meeting) “Promoting Biomedical Research, Equal Health and Environment in the post-COVID Syndemic Era”, European Society for Clinical Investigation (ESCI), Jun 2022, Bari, Italy. pp.118 / 56ASM-0082
Communication dans un congrès hal-04836119 v1

De la paillasse à la mise sur le marché : une cible pour le traitement de l'obésité: Le récepteur de la Ghréline

Sonia Cantel , Séverine Denoyelle , Jean‐louis Baneres , Jean Martínez , Jean-Alain Fehrentz
UTT Montpellier, Feb 2022, Montpellier, France
Communication dans un congrès hal-04892238 v1

Growth hormone secretagogues in Duchenne muscular dystrophy: a preclinical evaluation of potential benefits on muscle function and morphology

Paola Mantuano , Brigida Boccanegra , Ornella Cappellari , Santa Cirmi , Elena Bresciani et al.
27th International Hybrid Annual Congress of the World Muscle Society (WMS 2022), World Muscle Society (WMS), Oct 2022, Halifax, NS, Canada. pp.S128 / VP.84, ⟨10.1016/j.nmd.2022.07.358⟩
Communication dans un congrès hal-04837446 v1

Ghrelin receptor: design and evaluation of inverse agonists

Séverine Denoyelle
GDR3545 – GPCR International Meeting, Oct 2019, Montpellier, France
Communication dans un congrès hal-04833466 v1

Le récepteur de la Ghréline : une cible majeure pour le développement de ligands à visée thérapeutique

Séverine Denoyelle
Conférences ED459, Jun 2019, Montpellier, France
Communication dans un congrès hal-04833456 v1

Interplay between ghrelin and novel analogs of LEAP2, an endogenous ghrelin receptor antagonist: receptor activation and food intake regulation

Lucie Holá , Alena Karnošová , Miroslava Blechová , Blanka Železná , Jaroslav Kuneš et al.
36th European Peptide Symposium & 12th International Peptide Symposium, Aug 2022, Sitges (Barcelona), Spain. Wiley, Journal of Peptide Science, 28 (S3), pp.P041, 2022
Poster de conférence hal-04834748 v1