Thierry Billard

113
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Publications

Image document

CF<sub>3</sub>S-N bond formation under mild conditions. Easy access to trifluoromethanesulfenamides with a versatile reagent

Clément Delobel , Fabien Toulgoat , Thierry Billard
Journal of Fluorine Chemistry, 2024, 279, pp.110353. ⟨10.1016/j.jfluchem.2024.110353⟩
Article dans une revue hal-04729048 v1
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Perspectives on obesity imaging: [18F]2FNQ1P a specific 5-HT6 brain PET radiotracer

Pierre Courault , Sandrine Bouvard , Caroline Bouillot , Radu Bolbos , Waël Zeinyeh et al.
International Journal of Obesity, 2024, ⟨10.1038/s41366-024-01644-x⟩
Article dans une revue hal-04793046 v1
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Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source

Lilian Wisson , Gilles Hanquet , Fabien Toulgoat , Thierry Billard , Armen Panossian et al.
European Journal of Organic Chemistry, In press, 27 (28), pp.e202400388. ⟨10.1002/ejoc.202400388⟩
Article dans une revue hal-04591124 v1
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Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties

Clémence Bonnefoy , Adrien Gallego , Clément Delobel , Betty Raynal , Maxime Decourt et al.
European Journal of Organic Chemistry, 2024, 27 (18), pp.e202400142. ⟨10.1002/ejoc.202400142⟩
Article dans une revue hal-04591439 v1
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Phenylseleno trifluoromethoxylation of alkenes

Clément Delobel , Armen Panossian , Gilles Hanquet , Frédéric R Leroux , Fabien Toulgoat et al.
Beilstein Journal of Organic Chemistry, 2024, 20, pp.2434-2441. ⟨10.3762/bjoc.20.207⟩
Article dans une revue hal-04711420 v1
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WAY-208466, a 5-HT6 receptor agonist, increases food motivation in primates: A behavioural and PET imaging study opening perspectives in eating disorders

Mathilde Pitoy , Julie Maulavé , Lisa Gauthier , Justine Debatisse , Nicolas Costes et al.
Neuroscience Applied, 2024, 3, pp.104086. ⟨10.1016/j.nsa.2024.104086⟩
Article dans une revue hal-04811333 v1
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A journey into trifluoromethylchalcogenation: some reagents from Lyon

Thierry Billard
Comptes Rendus. Chimie, 2024, 27 (G1), pp.217-226. ⟨10.5802/crchim.341⟩
Article dans une revue hal-04781579 v1
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Deep Study of Thiocarbamoyl Fluorides: Synthesis and Properties

Clément Delobel , Emmanuel Chefdeville , Fabien Toulgoat , Thierry Billard
Advanced Synthesis and Catalysis, 2024, 366 (16), pp.3474-3480. ⟨10.1002/adsc.202400412⟩
Article dans une revue hal-04684868 v1
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Focus on Physico‐Chemical Properties of Sulfoximines: Acidity, Basicity and Lipophilicity

Elsa Anselmi , Bénédicte Montigny , Märt Lõkov , Carmen Kesküla , Jan Erik Soosaar et al.
Chemistry - A European Journal, 2024, 31 (1), pp.e202402329. ⟨10.1002/chem.202402329⟩
Article dans une revue hal-04814363 v1
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Difluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H‐Bearing N‐Heterocycles.

Anaïs Loison , Gilles Hanquet , Fabien Toulgoat , Thierry Billard , Armen Panossian et al.
European Journal of Organic Chemistry, 2023, 26 (42), pp.e202300695. ⟨10.1002/ejoc.202300695⟩
Article dans une revue hal-04163739 v2
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Comprehensive Study and Development of a Metal-Free and Mild Nucleophilic Trifluoromethoxylation

Clémence Bonnefoy , Armen Panossian , Gilles Hanquet , Frédéric Leroux , Fabien Toulgoat et al.
Chemistry - A European Journal, 2023, 29 (46), ⟨10.1002/chem.202301513⟩
Article dans une revue hal-04165325 v1

Perfluoroalkyl Selenoxides, Selenones and Selenoximines: General Preparation and Properties

Arnaud de Zordo-Banliat , Kevin Grollier , Nicolas Vanthuyne , Sébastien Floquet , Thierry Billard et al.
Angewandte Chemie International Edition, 2023, 62 (12), ⟨10.1002/anie.202300951⟩
Article dans une revue hal-04046563 v1
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Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C−H Activation

Arnaud de Zordo-Banliat , Kevin Grollier , Jordan Vigier , Erwann Jeanneau , Guillaume Dagousset et al.
Chemistry - A European Journal, In press, ⟨10.1002/chem.202202299⟩
Article dans une revue hal-03784203 v1
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Electrochemical Trifluoromethylselenolation of Activated Alkyl Halides

Kevin Grollier , Clément Ghiazza , Anis Tlili , Thierry Billard , Maurice Médebielle et al.
European Journal of Organic Chemistry, 2022, 2022 (19), ⟨10.1002/ejoc.202200123⟩
Article dans une revue hal-03834330 v1
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Study of Carbamoyl Fluoride: Synthesis, Properties and Applications

Clémence Bonnefoy , Emmanuel Chefdeville , Christian Tourvieille , Armen Panossian , Gilles Hanquet et al.
Chemistry - A European Journal, 2022, 28 (43), ⟨10.1002/chem.202201589⟩
Article dans une revue hal-03744602 v1
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Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds

Anaïs Loison , Gilles Hanquet , Fabien Toulgoat , Thierry Billard , Armen Panossian et al.
Organic Letters, 2022, ⟨10.1021/acs.orglett.2c03283⟩
Article dans une revue hal-03843401 v1
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Synthesis, Reactivity and Activation Modes of Fluoroalkyl Thiosulfonates and Selenosulfonates

Clément Ghiazza , Thierry Billard
European Journal of Organic Chemistry, 2021, 2021 (41), pp.5571-5584. ⟨10.1002/ejoc.202100944⟩
Article dans une revue hal-03834333 v1
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Different alterations of agonist and antagonist binding to 5-HT1A receptor in a rat model of Parkinson's disease and levodopa-induced dyskinesia : a microPET study

Benjamin Vidal , Élise Levigoureux , Sarah Chaib , Caroline Bouillot , Thierry Billard et al.
Journal of Parkinson's disease, 2021, 11 (3), pp.1257-1269. ⟨10.3233/JPD-212580⟩
Article dans une revue hal-03407557 v1
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[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations

Matthieu Colom , Benjamin Vidal , Sylvain Fieux , Jérôme Redouté , Nicolas Costes et al.
Frontiers in Neuroscience, 2021, 15, pp.622423. ⟨10.3389/fnins.2021.622423⟩
Article dans une revue hal-03407570 v1
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Recent synthetic methods towards the –OCHF2 moiety

Anaïs Loison , Fabien Toulgoat , Thierry Billard , Gilles Hanquet , Armen Panossian et al.
Tetrahedron, 2021, 99, pp.132458. ⟨10.1016/j.tet.2021.132458⟩
Article dans une revue hal-03517915 v1
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Aromatic Trifluoromethylselenolation via Pd-catalyzed C-H functionalization

Kevin Grollier , Emmanuel Chefdeville , Erwann Jeanneau , Thierry Billard
Chemistry - A European Journal, 2021, 27 (50), pp.12910-12916. ⟨10.1002/chem.202102121⟩
Article dans une revue hal-03407550 v1
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Solvent free nucleophilic selenocyanation with [bmim][SeCN]. Direct access to perfluoroalkylselenide compounds

Arnaud De-Zordo Banliat , Kévin Grollier , Aurélie Damond , Thierry Billard , Guillaume Dagousset et al.
Tetrahedron, 2021, 101, pp.132507. ⟨10.1016/j.tet.2021.132507⟩
Article dans une revue hal-03834344 v1
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(Trifluoromethylselenyl)methylchalcogenyl as emerging fluorinated groups: synthesis under photoredox catalysis and determination of the lipophilicity

Kevin Grollier , Arnaud de Zordo‐banliat , Flavien Bourdreux , Bruce Pegot , Guillaume Dagousset et al.
Chemistry - A European Journal, 2021, 27 (19), pp.6028-6033. ⟨10.1002/chem.202100053⟩
Article dans une revue hal-03407531 v1
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Fe-mediated nucleophilic trifluoromethylselenolation of activated alkyl bromides via umpolung reactivity of trifluoromethyl tolueneselenosulfinate

Kevin Grollier , Emmanuel Chefdeville , Arnaud de Zordo-Banliat , Bruce Pegot , Guillaume Dagousset et al.
Tetrahedron, 2021, 100, pp.132498. ⟨10.1016/j.tet.2021.132498⟩
Article dans une revue hal-03834329 v1
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Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4‐Dinitro‐Trifluoromethoxybenzene

Clémence Bonnefoy , Emmanuel Chefdeville , Armen Panossian , Gilles Hanquet , Frédéric R. Leroux et al.
Chemistry - A European Journal, 2021, 27 (64), pp.15986-15991. ⟨10.1002/chem.202102809⟩
Article dans une revue hal-03582991 v1
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Metal-free nucleophilic trifluoromethylselenolation via an iodide-mediated umpolung reactivity of trifluoromethylselenotoluenesulfonate

Kevin Grollier , Alexis Taponard , Arnaud de Zordo-Banliat , Emmanuel Magnier , Thierry Billard
Beilstein Journal of Organic Chemistry, 2020, 16, pp.3032 - 3037. ⟨10.3762/bjoc.16.252⟩
Article dans une revue hal-03097741 v1

Fluoroalkylselenolation of Alkyl Silanes/Trifluoroborates under Metal-Free Visible-Light Photoredox Catalysis

Clément Ghiazza , Lhoussain Khrouz , Thierry Billard , Cyrille Monnereau , Anis Tlili
European Journal of Organic Chemistry, 2020, 2020 (10), pp.1559-1566. ⟨10.1002/ejoc.201901063⟩
Article dans une revue hal-03008842 v1
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18F-F13640 PET imaging of functional receptors in humans

Matthieu Colom , Nicolas Costes , Jérôme Redouté , Frédéric Dailler , Florent Gobert et al.
European Journal of Nuclear Medicine and Molecular Imaging, 2020, 47 (1), pp.220-221. ⟨10.1007/s00259-019-04473-7⟩
Article dans une revue hal-02305453 v1
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Environmentally Compatible Access to α‐Trifluoromethylseleno‐Enones

Kevin Grollier , Alexis Taponard , Clément Ghiazza , Emmanuel Magnier , Thierry Billard
Helvetica Chimica Acta, 2020, 103 (11), ⟨10.1002/hlca.202000185⟩
Article dans une revue hal-03033317 v1
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Synthetic Approaches to Fluoroalkyltelluryl-Substituted Compounds

Kévin Grollier , Alexis Taponard , Thierry Billard
European Journal of Organic Chemistry, 2020, 2020 (45), pp.6943-6954. ⟨10.1002/ejoc.202000839⟩
Article dans une revue hal-03043875 v1
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Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer’s Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P

Pierre Courault , Stéphane Emery , Sandrine Bouvard , François Liger , Fabien Chauveau et al.
Journal of Alzheimer's Disease, 2020, 75 (4), pp.1329-1338. ⟨10.3233/JAD-191278⟩
Article dans une revue hal-03035778 v1
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Preclinical validation of [18F]2FNQ1P as a specific PET radiotracer of 5-HT6 receptors in rat, pig, non-human primate and human brain tissue

Stéphane Emery , Sylvain Fieux , Benjamin Vidal , Pierre Courault , Sandrine Bouvard et al.
Nuclear Medicine and Biology, 2020, 82-83, pp.57-63. ⟨10.1016/j.nucmedbio.2020.01.006⟩
Article dans une revue hal-03035781 v1

Merging Visible-Light Catalysis for the Direct Late-Stage Group-16-Trifluoromethyl Bond Formation

Clément Ghiazza , Thierry Billard , Anis Tlili
Chemistry - A European Journal, 2019, 25 (26), pp.6482-6495. ⟨10.1002/chem.201806234⟩
Article dans une revue hal-02107065 v1
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11 C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles

François Liger , Florence Cadarossanesaib , Thibaut Iecker , Christian Tourvieille , Didier Le Bars et al.
European Journal of Organic Chemistry, 2019, 2019 (41), pp.6968-6972. ⟨10.1002/ejoc.201901386⟩
Article dans une revue hal-02382036 v1
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Visible-Light-Mediated Synthesis of Trifluoromethylthiolated Arenes

Clément Ghiazza , Cyrille Monnereau , Lhoussain Khrouz , Thierry Billard , Anis Tlili
Synthesis: Journal of Synthetic Organic Chemistry, 2019, 51 (14), pp.2865-2870. ⟨10.1055/s-0037-1610322⟩
Article dans une revue hal-03008849 v1
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Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!

Min Zhang , Gaëlle Hugon , Caroline Bouillot , Radu Bolbos , Jean-Baptiste Langlois et al.
Contrast Media and Molecular Imaging, 2019, 2019, pp.9294586. ⟨10.1155/2019/9294586⟩
Article dans une revue hal-02278818 v1

Difluoro(aryl)(perfluoroalkyl)‐λ 4 ‐sulfanes and Selanes: Missing Links of Trichloroisocyanuric Acid/Potassium Fluoride Chemistry

Fabian Brüning , Cody Ross Pitts , Jorna Kalim , Dustin Bornemann , Clément Ghiazza et al.
Angewandte Chemie International Edition, 2019, 58 (52), pp.18937-18941. ⟨10.1002/anie.201910594⟩
Article dans une revue hal-04409441 v1
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Chalcogen OCF 3 Isosteres Modulate Drug Properties without Introducing Inherent Liabilities

Clément Ghiazza , Thierry Billard , Callum Dickson , Anis Tlili , Christian Gampe
ChemMedChem, 2019, 14 (17), pp.1586-1589. ⟨10.1002/cmdc.201900452⟩
Article dans une revue hal-03035756 v1

New Avenues in Radical Trifluoromethylselenylation with ­Trifluoromethyl Tolueneselenosulfonate

Clément Ghiazza , Cyrille Monnereau , Lhoussain Khrouz , Maurice Médebielle , Thierry Billard et al.
SYNLETT, 2019, 30 (07), pp.777-782. ⟨10.1055/s-0037-1610347⟩
Article dans une revue hal-02106887 v1
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Evaluation of [18F]2FP3 in pigs and non-human primates

Hanne Hansen , Cristian Constantinescu , Olivier Barret , Matthias Herth , Janus Magnussen et al.
Journal of Labelled Compounds and Radiopharmaceuticals, 2019, 62 (1), pp.34-42. ⟨10.1002/jlcr.3692⟩
Article dans une revue hal-02109621 v1

Umpolung Reactivity of Fluoroalkylselenotoluenesulfonates: Towards a Versatile Reagent

Clément Ghiazza , Alex Kataria , Anis Tlili , Fabien Toulgoat , Thierry Billard
Asian Journal of Organic Chemistry, 2019, ⟨10.1002/ajoc.201900027⟩
Article dans une revue hal-02106892 v1

Fluorous l -Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity

Albert Granados , Anna Del Olmo , Francesca Peccati , Thierry Billard , Mariona Sodupe et al.
Journal of Organic Chemistry, 2018, 83 (1), pp.303-313. ⟨10.1021/acs.joc.7b02685⟩
Article dans une revue hal-02382031 v1

Regioselective remote C H fluoroalkylselenolation of 8-aminoquinolines

Clément Ghiazza , Moussa Ndiaye , Anfal Hamdi , Anis Tlili , Thierry Billard
Tetrahedron, 2018, 74 (45), pp.6521-6526. ⟨10.1016/j.tet.2018.09.048⟩
Article dans une revue hal-02109638 v1

Visible-Light-Mediated Metal-Free Synthesis of Trifluoromethylselenolated Arenes

Clément Ghiazza , Vincent Debrauwer , Cyrille Monnereau , Lhoussain Khrouz , Maurice Médebielle et al.
Angewandte Chemie International Edition, 2018, 57 (36), pp.11781 - 11785. ⟨10.1002/anie.201806165⟩
Article dans une revue hal-01889009 v1

Direct α-C-H Trifluoromethylselenolation of Carbonyl Compounds

Clément Ghiazza , Anis Tlili , Thierry Billard
European Journal of Organic Chemistry, 2018, 2018 (27-28), pp.3680-3683. ⟨10.1002/ejoc.201800237⟩
Article dans une revue hal-02109647 v1

A Metal-Free Route to Heterocyclic Trifluoromethyl- and Fluoroalkylselenolated Molecules

Quentin Glenadel , Ermal Ismalaj , Thierry Billard
Organic Letters, 2018, 20 (1), pp.56-59. ⟨10.1021/acs.orglett.7b03338⟩
Article dans une revue hal-02382029 v1
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Amyloid-beta radiotracer [18F]BF-227 does not bind to cytoplasmic glial inclusions of post-mortem Multiple System Atrophy brain tissue

Mathieu Verdurand , Élise Levigoureux , Sophie Lancelot , Waël Zeinyeh , Thierry Billard et al.
Contrast Media and Molecular Imaging, 2018, 2018, ⟨10.1155/2018/9165458⟩
Article dans une revue hal-01691091 v1
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In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging

Mathieu Verdurand , Élise Levigoureux , Waël Zeinyeh , Laurent Berthier , Meriem Mendjel-Herda et al.
Molecular Pharmaceutics, 2018, 15 (8), pp.3153-3166. ⟨10.1021/acs.molpharmaceut.8b00229⟩
Article dans une revue hal-01955442 v1

Nucleophilic trifluoromethylthiolation of organoselenocyanates with trifluoromethanesulfenamide reagent: Access to CF3SSe-containing compounds

Quentin Glenadel , Camille Ayad , Marc-Alexandre D’elia , Thierry Billard , Fabien Toulgoat
Journal of Fluorine Chemistry, 2018, 210, pp.112-116. ⟨10.1016/j.jfluchem.2018.03.009⟩
Article dans une revue hal-02109639 v1

Visible-light promoted fluoroalkylselenolation: toward the reactivity of unsaturated compounds

Clément Ghiazza , Lhoussain Khrouz , Cyrille Monnereau , Thierry Billard , Anis Tlili
Chemical Communications, 2018, 54 (71), pp.9909 - 9912. ⟨10.1039/C8CC05256E⟩
Article dans une revue hal-01889019 v1

Visible‐Light‐Mediated Metal‐Free Synthesis of Trifluoromethylselenolated Arenes

Clément Ghiazza , Vincent Debrauwer , Cyrille Monnereau , Lhoussain Khrouz , Maurice Médebielle et al.
Angewandte Chemie International Edition, 2018, 57 (36), pp.11781-11785. ⟨10.1002/anie.201806165⟩
Article dans une revue hal-03093873 v1

Exploring the Reactivity of Trifluoromethyl Tolueneselenosulfonate with Alkynes under Copper Catalysis

Clément Ghiazza , Vincent Debrauwer , Thierry Billard , Anis Tlili
Chemistry - A European Journal, 2018, 24 (1), pp.97-100. ⟨10.1002/chem.201705231⟩
Article dans une revue hal-02109631 v1

Synthetic Approaches to Trifluoromethylselenolated Compounds

Anis Tlili , Ermal Ismalaj , Quentin Glenadel , Clément Ghiazza , Thierry Billard
Chemistry - A European Journal, 2018, 24 (15), pp.3659-3670. ⟨10.1002/chem.201704637⟩
Article dans une revue hal-02382034 v1

18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging

Benjamin Vidal , Sylvain Fieux , Matthieu Colom , Thierry Billard , Caroline Bouillot et al.
Brain Structure and Function, 2018, 223 (6), pp.2973-2988. ⟨10.1007/s00429-018-1672-7⟩
Article dans une revue hal-02107028 v1

Trifluoromethyl‐ and Fluoroalkylselenolations of Alkynyl Copper(I) Compounds

Clément Ghiazza , Thierry Billard , Anis Tlili
Chemistry - A European Journal, 2017, 23 (42), pp.10013-10016. ⟨10.1002/chem.201702028⟩
Article dans une revue hal-04409412 v1

Inside Back Cover: Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines (Angew. Chem. Int. Ed. 1/2017)

Longin Justin Clair Bonazaba milandou , Hélène Carreyre , Sébastien Alazet , Gino Greco , Agnès Martin-Mingot et al.
Angewandte Chemie International Edition, 2017, 56 (1), pp.417 - 417. ⟨10.1002/anie.201611312⟩
Article dans une revue hal-01610196 v1
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[11C]PF-3274167 as a PET radiotracer of oxytocin receptors: Radiosynthesis and evaluation in rat brain

Benjamin Vidal , Iuliia Karpenko , François Liger , Sylvain Fieux , Caroline Bouillot et al.
Nuclear Medicine and Biology, 2017, 55, pp.1-6. ⟨10.1016/j.nucmedbio.2017.07.008⟩
Article dans une revue hal-01689748 v1

Generation of the SCF3 radical by photoredox catalysis: Intra- and intermolecular carbotrifluoromethylthiolation of alkenes

Guillaume Dagousset , Cédric Simon , Elsa Anselmi , Béatrice Tuccio , Thierry Billard et al.
Chemistry - A European Journal, 2017, 23 (18), pp.4282-4286. ⟨10.1002/chem.201700734⟩
Article dans une revue hal-01606062 v1
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Electrophilic Trifluoromethylselenolation of Boronic Acids

Clément Ghiazza , Anis Tlili , Thierry Billard
Molecules, 2017, Tri- and Di-Fluoromethylation and Tri- and Di-Fluoromethylchalcogenation Reactions, 22 (5), pp.833. ⟨10.3390/molecules22050833⟩
Article dans une revue hal-04409404 v1

Trifluoromethylselenolation and Fluoroalkylselenolation of Alkenes by Electrophilic Addition

Clément Ghiazza , Quentin Glenadel , Anis Tlili , Thierry Billard
European Journal of Organic Chemistry, 2017, 2017 (26), pp.3812-3814. ⟨10.1002/ejoc.201700643⟩
Article dans une revue hal-04409410 v1
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Electrophilic trifluoromethylselenolation of terminal alkynes with Se -(trifluoromethyl) 4-methylbenzenesulfonoselenoate

Clément Ghiazza , Anis Tlili , Thierry Billard
Beilstein Journal of Organic Chemistry, 2017, 13, pp.2626-2630. ⟨10.3762/bjoc.13.260⟩
Article dans une revue hal-04409417 v1
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Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors

Véronique Sgambato-Faure , Thierry Billard , Elise Metereau , Sandra Duperrier , Sylvain Fieux et al.
Frontiers in Pharmacology, 2017, 8, pp.471. ⟨10.3389/fphar.2017.00471⟩
Article dans une revue hal-01689720 v1

Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines

Longin Justin Clair Bonazaba milandou , Hélène Carreyre , Sébastien Alazet , Gino Greco , Agnès Martin-Mingot et al.
Angewandte Chemie, 2017, 129 (1), pp.175 - 178. ⟨10.1002/ange.201609574⟩
Article dans une revue hal-01598373 v1

Innenrücktitelbild: Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines (Angew. Chem. 1/2017)

Longin Justin Clair Bonazaba milandou , Hélène Carreyre , Sébastien Alazet , Gino Greco , Agnès Martin-Mingot et al.
Angewandte Chemie, 2017, 129 (1), pp.429 - 429. ⟨10.1002/ange.201611312⟩
Article dans une revue hal-01610193 v1

Copper-catalyzed perfluoroalkylthiolation of alkynes with perfluoroalkanesulfenamides

Anis Tlili , Sébastien Alazet , Quentin Glenadel , Thierry Billard
Chemistry - A European Journal, 2016, 22 (29), pp.10230-10234. ⟨10.1002/chem.201601338⟩
Article dans une revue istex hal-01484732 v1

Metal-free direct nucleophilic perfluoroalkylthiolation with perfluoroalkanesulfenamides

Quentin Glenadel , Mathieu Bordy , Sébastien Azalet , Anis Tlili , Thierry Billard
Asian Journal of Organic Chemistry, 2016, 5 (3), pp.428-433. ⟨10.1002/ajoc.201600003⟩
Article dans une revue istex hal-01313903 v1

Agonist and antagonist bind differently to 5-HT1A recptors during Alzheimer's disease : a post-mortem study with PET radiopharmaceutical

B. Vidal , J. Sebti , M. Verdurand , S. Fieux , T. Billard et al.
Neuropharmacology, 2016, 109, pp.88-95. ⟨10.1016/j.neuropharm.2016.05.009⟩
Article dans une revue hal-01484762 v1

Metal-free direct dehydroxytri-fluoromethylthiolation of alcohols via the umpolung reactivity of trifluoromethanesulfenamides

Quentin Glenadel , Anis Tlili , Thierry Billard
European Journal of Organic Chemistry, 2016, 2016 (11), pp.1955-1957. ⟨10.1002/ejoc.201600197⟩
Article dans une revue istex hal-01313146 v1

Multigram scale syntheses of first and second generation of trifluoromethanesulfenamide reagents

Quentin Glenadel , Sébastien Alazet , François Baert , Thierry Billard
Organic Process Research and Development, 2016, 20, pp.960-964. ⟨10.1021/acs.oprd.6b00062⟩
Article dans une revue hal-01484781 v1

Direct ectrophilic (Benzenesulfonyl)difluoromethylthiolation with a shelf-stable reagent

E. Ismalaj , D. Le Bars , T. Billard
Angewandte Chemie International Edition, 2016, 55 (15), pp.4790-93
Article dans une revue hal-01313893 v1

Benzyltrifluoromethyl (or Fluoroalkyl) selenide : reagent for electrophilic trifluoromethyl (or fluoroalkyl) selenolation

Quentin Glenadel , Ermal Ismalaj , Thierry Billard
Journal of Organic Chemistry, 2016, 81 (18), pp.8268-8275. ⟨10.1021/acs.joc.6b01344⟩
Article dans une revue hal-01484715 v1

Synthetic approaches to trifluoromethoxy-substituted compounds

Anis Tlili , Fabien Toulgoat , Thierry Billard
Angewandte Chemie International Edition, 2016, 55 (39), pp.11726-11735. ⟨10.1002/anie.201603697⟩
Article dans une revue istex hal-01484721 v1
Image document

Direct [ 11 C]Methylation of Amines from [11C]CO 2 for the Synthesis of PET Radiotracers

François Liger , Ture Eijsbouts , Florence Cadarossanesaib , Christian Tourvieille , Didier Le Bars et al.
European Journal of Organic Chemistry, 2015, 2015 (29), pp.6434-6438. ⟨10.1002/ejoc.201500924⟩
Article dans une revue hal-03719209 v1

Mild and soft catalyzed trifluoromethylthiolation of boronic acids : the crucial role of water

Quentin Glenadel , Sébastien Alazet , Anis Tlili , Thierry Billard
Chemistry - A European Journal, 2015, 21 (42), pp.14694-14698. ⟨10.1002/chem.201502338⟩
Article dans une revue istex hal-01313928 v1

First and second generation of trifluoromethanesulfenamide reagent : a trifluoromethylthiolating comparison

Quentin Glenadel , Sébastien Alazet , Thierry Billard
Journal of Fluorine Chemistry, 2015, 179, pp.89-95. ⟨10.1016/j.jfluchem.2015.06.007⟩
Article dans une revue hal-01313914 v1

Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging

Guillaume Becker , Julie Colomb , Véronique Sgambato-Faure , Léon Tremblay , Thierry Billard et al.
European Journal of Nuclear Medicine and Molecular Imaging, 2015, 42 (3), pp.495-502. ⟨10.1007/s00259-014-2936-y⟩
Article dans une revue hal-01128421 v1

Le fluor en chimie organique : une montée en puissance (Fluorine in organic chemistry gaining momentum)

Thierry Billard , Emmanuel Magnier , Jean-Pierre Vors
L'Actualité Chimique, 2015, 393-394, pp.56-61
Article dans une revue hal-01313987 v1

Acid-catalyzed synthesis of α-trifluoromethylthiolated carbonyl compounds

Sébastien Alazet , Ermal Ismalaj , Quentin Glenadel , Didier Le Bars , Thierry Billard
European Journal of Organic Chemistry, 2015, 2015 (21), pp.4607-4610. ⟨10.1002/ejoc.201500710⟩
Article dans une revue istex hal-01313958 v1

A Postmortem Study to Compare Agonist and Antagonist 5-HT1A Receptor-binding Sites in Alzheimer's Disease

Guillaume Becker , Nathalie Streichenberger , Thierry Billard , Adrian Newman-Tancredi , Luc Zimmer
CNS Neuroscience and Therapeutics, 2014, 20 (10), pp.930-934. ⟨10.1111/cns.12306⟩
Article dans une revue hal-01128433 v1

Binding of the PET Radiotracer [18F]BF227 Does not Reflect the Presence of Alpha-Synuclein Aggregates in Transgenic Mice

Élise Levigoureux , Sophie Lancelot , Caroline Bouillot , Fabien Chauveau , Mathieu Verdurand et al.
Current Alzheimer Research, 2014, 11 (10), pp.955-960. ⟨10.2174/1567205011666141107154201⟩
Article dans une revue hal-01128444 v1

PET radiotracers for molecular imaging of serotonin 5-HT1A receptors

T. Billard , D. Le Bars , L. Zimmer
Current Medicinal Chemistry, 2014, 21 (1), pp.70-80. ⟨10.2174/09298673113209990215⟩
Article dans une revue istex hal-00947714 v1

Molecular imaging of the serotonin 5-HT7 receptors: from autoradiography to positron emission tomography

L. Zimmer , T. Billard
Reviews in the Neurosciences, 2014, 25 (3), pp.357-365. ⟨10.1515/revneuro-2014-0003⟩
Article dans une revue hal-00947703 v1

Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes

S. Alazet , L. Zimmer , T. Billard
Angewandte Chemie International Edition, 2013, 52 (41), pp.10814-10817. ⟨10.1002/anie.201305179⟩
Article dans une revue hal-00948085 v1

Radiosynthesis and Preclinical Evaluation of 18F-F13714 as a Fluorinated 5-HT1A Receptor Agonist Radioligand for PET Neuroimaging

L. Lemoine , G. Becker , B. Vacher , T. Billard , S. Lancelot et al.
Journal of Nuclear Medicine, 2012, 53 (6), pp.969-976. ⟨10.2967/jnumed.111.101212⟩
Article dans une revue hal-00821174 v1

2,2'-Bipyridine-3,3'-dicarboxylic carbohydrate esters and amides. Synthesis and preliminary evaluation as ligands in Cu(II)-catalysed enantioselective electrophilic fluorination.

Aurélie Assalita , Thierry Billard , Stéphane Chambert , Bernard R. Langlois , Yves Queneau et al.
Tetrahedron: Asymmetry, 2009, 20 (5), pp.593-601. ⟨10.1016/j.tetasy.2009.02.050⟩
Article dans une revue istex hal-01305046 v1

Synthesis and biological evaluation of [18F]N-[2-(1-[(4-fluorophenyl)sulfonyl]-1H-indol-4-yloxy)ethyl]-N,N-dimethylamine as a potential 5-HT6 PET antagonist,

S. Tang , M. Verdurand , B. Joseph , L. Lemoine , D. Daoust et al.
Nuc. Med. Biol.,, 2007, 34, pp.995
Article dans une revue hal-00171079 v1

Trifluoromethanesulfinic Acid Derivatives as Nucleophilic Trifluoromethylating Reagents

David Inschauspe , Jean-Baptiste Sortais , Thierry Billard , Bernard Langlois
SYNLETT, 2003, 2, pp.0233-0235. ⟨10.1055/s-2003-36788⟩
Article dans une revue hal-03639867 v1

Fluoride-assisted trifluoromethylation of aromatic thiones with (trifluoromethyl)trimethylsilane

Sylvie Large-Radix , Thierry Billard , Bernard R. Langlois
Journal of Fluorine Chemistry, 2003, 124 (2), pp.147 - 149. ⟨10.1016/S0022-1139(03)00203-3⟩
Article dans une revue istex hal-01800170 v1

Telomerization of vinylidene fluoride with alkyl (or aryl) trifluoromethanethiosulfonates

Bruno Ameduri , Thierry Billard , Bernard Langlois
Journal of Polymer Science Part A: Polymer Chemistry, 2002, 40 (24), pp.4538-4549. ⟨10.1002/pola.10535⟩
Article dans une revue hal-05083918 v1

Electrophilic Trifluoromethylation of Vinyl Sulfides

Bernard R. Langlois , Thierry Billard , Sophie Guérin , Sylvie Large , Nathalie Roidot-Perol
Phosphorus, Sulfur, and Silicon and the Related Elements, 1999, 153 (1), pp.323 - 324. ⟨10.1080/10426509908546452⟩
Article dans une revue hal-01800163 v1

Synthesis of Trifluoromethyl Selenides

Thierry Billard , Bernard R. Langlois , Sylvie Large
Phosphorus, Sulfur, and Silicon and the Related Elements, 1998, 136 (1), pp.521 - 524. ⟨10.1080/10426509808545987⟩
Article dans une revue hal-01800167 v1

Preparation of trifluoromethyl sulfides or selenides from trifluoromethyl trimethylsilane and thiocyanates or selenocyanates

Thierry Billard , Sylvie Large , Bernard R. Langlois
Tetrahedron Letters, 1997, 38 (1), pp.65 - 68. ⟨10.1016/S0040-4039(96)02216-2⟩
Article dans une revue istex hal-01800102 v1

A New Route to Thio- and Selenosulfonates from Disulfides and Diselenides. Application to the Synthesis of New Thio- and Selenoesters of Triflic Acid

Thierry Billard , Bernard R. Langlois , Sylvie Large , Daniel Anker , Nathalie Roidot et al.
Journal of Organic Chemistry, 1996, 61 (21), pp.7545 - 7550. ⟨10.1021/jo960619c⟩
Article dans une revue istex hal-01800094 v1

A versatile reagent: 2,4-Dinitro-trifluoromethoxybenzene (DNTFB).

Thierry Billard
24th International Symposium on Fluorine Chemistry, Jul 2024, Shanghai, China
Communication dans un congrès hal-04720232 v1

Un isotope «non-naturel» du Fluor : Le Fluor-18

Thierry Billard
4ème édition du Colloque Français de Chimie du Fluor, May 2024, Le Mans, France
Communication dans un congrès hal-04720226 v1

2,4-Dinitro-trifluoromethoxybenzene (DNTFB): a promising reagent in fluorine chemistry

Thierry Billard
26th Winter Fluorine Conference, Jan 2023, Clearwater Beach, United States
Communication dans un congrès hal-04720203 v1

New Reagents for Trifluoromethylchalcogenation

Thierry Billard
The XXIII International Conference on Organic Synthesis (23-ICOS), Oct 2023, Shanghai, China
Communication dans un congrès hal-04720217 v1

Merging Fluorinated Moieties and Heteroatoms: Opportunities in Emerging Fluorinated Groups Design

Thierry Billard
23rd International Symposium on Fluorine Chemistry, Jul 2023, Québec, Canada
Communication dans un congrès hal-04720208 v1

From Fluorinated Emerging Groups to Isotopic Labeled Molecules: New Tools for Medicinal Chemistry

Thierry Billard
Indo-French Seminar: Synergy of Chemistry and Biology towards Affordable Health, Nov 2023, Hyderabad, India
Communication dans un congrès hal-04720223 v1

Trifluoromethylselenosulfonates: Versatile reagents in Fluorine chemistry

Thierry Billard
20th European symposium on Fluorine Chemistry, Aug 2022, Berlin, Germany
Communication dans un congrès hal-04720198 v1

Fluorinated chalcogenosulfonates: Versatile reagents in fluorine chemistry

Thierry Billard
Pacifichem 2021, Dec 2021, Honolulu & Virtual, United States
Communication dans un congrès hal-04720187 v1
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A screening assay in the search of an alpha-synuclein PET radioligand

Mathieu Verdurand , Meriem Mendjel-Herda , Élise Levigoureux , Sophie Lancelot , Waël Zeinyeh et al.
World Molecular Imaging Congress (WMIC 2015), Sep 2015, Honolulu, United States
Communication dans un congrès hal-01207698 v1
Image document

A screening assay in the search of an alpha-synuclein PET radioligand

Mathieu Verdurand , Meriem Mendjel-Herda , Élise Levigoureux , Sophie Lancelot , Waël Zeinyeh et al.
10th annual meeting of the European Society for Molecular Imaging (ESMI) - European Molecular Imaging Meeting (EMIM), Mar 2015, Tübingen, Germany
Communication dans un congrès hal-01207682 v1

Preclinical evaluation of serotonin 5-HT6 receptor radioligands for PET imaging

G. Becker , J. Colomb , T. Billard , L. Zimmer
Annual Congress of the European Association of Nuclear Medicine 2013, Oct 2013, Lyon, France
Communication dans un congrès hal-00948359 v1

A post-mortem study to compare the 5-HT1A receptor binding of a PET agonist and a PET antagonist in Alzheimer's disease

G. Becker , N. Streichenberger , T. Billard , B. Vacher , A. Newman-Tancredi et al.
Annual Congress of the European Association of Nuclear Medicine 2013, Oct 2013, Lyon, France
Communication dans un congrès hal-00948356 v1

Radiosynthesis and radiopharmacological evaluation of fluorinated PET radioligands for the 5-HT6 receptors

G. Becker , J. Colomb , T. Billard , L. Zimmer
Society of Nuclear Medicine Congress 2013, Jun 2013, Vancouver, Canada. pp.326
Communication dans un congrès hal-00948473 v1

Serotonin receptor imaging by 18F-PET

Thierry Billard , François Liger , Mathieu Verdurand
Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals, Elsevier, pp.459-518, 2018, ⟨10.1016/B978-0-12-812733-9.00013-1⟩
Chapitre d'ouvrage hal-02382038 v1

Towards CF3S group : from trifluoromethylationof sulfides to direct trifluoromethylthiolation

F. Toulgoat , T. Billard
Modern Synthesis Processes and Reactivity of Fluorinated Compounds : Progress in Fluorine, pp.141-179, 2017
Chapitre d'ouvrage hal-01484792 v1