Vincent HUIN

HUIN Vincent, M.D., Ph.D. Associate Professor, Department of Biochemistry and Molecular Biology
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Affiliations actuelles
  • Université de Lille
  • Lille Neurosciences & Cognition - U 1172 (LilNCog)
  • Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille)
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Présentation

HUIN Vincent, M.D., Ph.D.

Associate professor in Biochemistry and Molecular Biology, University of Lille, France

Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S1172, Team "Alzheimer & Tauopathies"

vincent.huin@inserm.fr / vincent.huin@chru-lille.fr

Tel: +33 359 899 605 / Fax: +33 320 538 562

French citizen

EDUCATION

INSTITUTION AND LOCATION DEGREE YEAR FIELD OF STUDY

University of Lille, Faculty of Medicine, Bachelor of Medicine 2007

University of Lille, B.Sc. (Master 1), Research in Biology-Health 2005

University of Rouen, B.Sc. (Master 1), Medical/Pharmaceutical Sciences & Biology-Health 2009

University of Lille, M.Sc. (Master 2), Research in Biology-Health 2011

University of Rouen and University Hospital of Rouen, M.D. Medical biology & genetics 2012

University of Paris Descartes, Paris (DIU), Diploma of Inborn errors of metabolism 2013

National examination for the position of hospital doctor,Medical biology 2016

University of Lille, Ph.D in Neurosciences 2016

University of Pierre et Marie Curie, Paris (DIU), Diploma of medical pedagogy 2019

University of Lille, Habilitation à diriger des recherches 2023

EMPLOYMENT

University Hospital of Lille, Professional practice and internship 2003-2007

University Hospital of Rouen, Postgraduate experience as Medical Intern 2007-2012

University Hospital of Lille, Specialty Registrar 2012-2017

Institut du Cerveau et de la moelle épinière (ICM), Paris, PostPh.D. 2017-2018

University of Lille and University Hospital of Lille, Associate professor 2018-present

OTHER ACADEMIC POSITIONS

Speech Therapy School of Lille, Head teacher in Biochemistry and Molecular Biology 2013-2016

HONORS and MEMBERSHIPS

Societies: Society for Neuroscience France; Association Nationale des Praticiens de Génétique Moléculaire (ANPGM); Société Française de Biochimie et Biologie Moléculaire; Collège national des Biochimistes et Biologistes Moléculaires Médicaux (CBBMM)

• Networks: Member of the clinical and genetics analysis of Spastic paraplegia and Ataxia network (European Spatax network); "BRAIN-TEAM": Filière de Santé Maladies Rares

Conference as invited speaker:

National scientific symposium of the charity « connaître les syndromes cérébelleux », France 2016

• Reviewer for the journal “Orphanet Journal of Rare Diseases”, "Scientific Reports" and "Neurology: Genetics"

Domaines de recherche

Biochimie, Biologie Moléculaire

Compétences

Genetics Moleculal Biology

Publications

Publications

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Comparing high and low amyloid producers in Alzheimer's disease: An in-depth analysis

Mélanie Leroy , Anne Laure Aziz , Susanna Schraen , Vincent Deramecourt , Emilie Skrobala et al.

Revue Neurologique, 2025, Revue Neurologique, ⟨10.1016/j.neurol.2025.02.004⟩

Article dans une revue hal-05025065v1
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HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance.

M. Mirabelli , E. Chiefari , B. Arcidiacono , A. Salatino , A. Pascarella et al.

EBioMedicine, 2025, EBioMedicine, 115, pp.105700. ⟨10.1016/j.ebiom.2025.105700⟩

Article dans une revue hal-05096463v1

Two case reports of RAB39B deletion displaying highly variable parkinsonism.

N. Geoffre , P. Jaulent , C. Laurencin , Guillaume Carey , Luc Defebvre et al.

Parkinsonism & related disorders, 2025, Parkinsonism Relat Disord, 135, pp.107824. ⟨10.1016/j.parkreldis.2025.107824⟩

Article dans une revue hal-05118087v1
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Conservative iron chelation for VAC14: Two-year clinical-radiological follow-up.

Thomas Ollivier , David Devos , Gregory Kuchcinski , Luc Defebvre , Vincent Huin et al.

J Parkinsons Dis, 2025, J Parkinsons Dis, pp.1877718X251331820. ⟨10.1177/1877718X251331820⟩

Article dans une revue hal-05096415v1

Late-onset cerebellar ataxia in three European patients with repeat expansions in RFC1 and FGF14: a case series

A. Hocquel , D. Pellerin , J. L. Mereaux , Vincent Huin , M. Hadjivassiliou et al.

Journal of Neurology, 2025, Journal of Neurology, 272 (500), ⟨10.1007/s00415-025-13234-6⟩

Article dans une revue hal-05237801v1
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Early-onset phenotype in a patient with an intermediate allele and a large SCA1 expansion: a case report.

Guillaume Baille , Nicolas Geoffre , Anna Wissocq , Eugenie Mutez , Nicolas Geoffre et al.

BMC Neurology, 2024, BMC Neurology, 24, ⟨10.1186/s12883-024-03846-2⟩

Article dans une revue hal-04976417v1
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Cognitive Impairment Is Part of the Phenotype of Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS)

Kathy Dujardin , Celine Tard , E. Diglé , V. Herlin , Eugenie Mutez et al.

Movement Disorders, 2024, Movement Disorders, 39 (5), pp.892-897. ⟨10.1002/mds.29750⟩

Article dans une revue hal-04688773v1

Reply to: "Further Evidence of Cerebellar Cognitive Affective/Schmahmann Syndrome in RFC1-Related Syndrome

Kathy Dujardin , Celine Tard , E. Diglé , V. Herlin , Eugenie Mutez et al.

Movement Disorders, 2024, Movement Disorders, 39 (7), pp.1248-1249. ⟨10.1002/mds.29886⟩

Article dans une revue hal-04688788v1
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Caffeine consumption outcomes on amyotrophic lateral sclerosis disease progression and cognition

Vincent Huin , David Blum , Violette Delforge , E. Cailliau , S. Djeziri et al.

Neurobiology of Disease, 2024, Neurobiology of Disease, 199, pp.106603. ⟨10.1016/j.nbd.2024.106603⟩

Article dans une revue hal-04684979v1

Late-onset Kjellin syndrome: Diagnosis of SPG11 on fundus examination

Vincent Brock , Anna Wissocq , Nicolas Geoffre , Caroline Marks , Vincent Canel et al.

European Journal of Ophthalmology, 2024, European Journal of Ophthalmology, 34 (4), pp.NP44 - NP46. ⟨10.1177/11206721241247418⟩

Article dans une revue hal-04990708v1
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Pseudohypoaldosteronism type II and sensory neuropathy associated with a heterozygous pathogenic variant in KLHL3 gene, a case report.

Jean-Baptiste Davion , Ilda Coku , A. Wissocq , A. Genet , J. Poupart et al.

HELIYON, 2024, HELIYON, 10, pp.e39891. ⟨10.1016/j.heliyon.2024.e39891⟩

Article dans une revue hal-04977471v1
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RFC1: Motifs and phenotypes.

Violette Delforge , Celine Tard , Jean-Baptiste Davion , Kathy Dujardin , Anna Wissocq et al.

Revue Neurologique, 2024, Revue Neurologique, ⟨10.1016/j.neurol.2024.03.006⟩

Article dans une revue (article de synthèse) hal-04586690v1
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Indication for molecular testing by multiplex ligation‐dependent probe amplification in parkinsonism

Eugénie Mutez , M. Swiderski , D. Devos , C. Moreau , G. Baille et al.

European Journal of Neurology, 2023, 30 (6), pp.1667-1675. ⟨10.1111/ene.15788⟩

Article dans une revue hal-04330019v1
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Conservative Iron Chelation for Neuroferritinopathy.

Felix Marchand , Caroline Moreau , Gregory Kuchcinski , Vincent Huin , Luc Defebvre et al.

Movement Disorders, 2022, Movement Disorders, 37 (9), pp.1948-1952. ⟨10.1002/mds.29145⟩

Article dans une revue hal-04769123v1
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Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.

Ilda Coku , Eugénie Mutez , Sabiha Eddarkaoui , Sébastien Carrier , Antoine Marchand et al.

Movement Disorders, 2022, ⟨10.1002/mds.29124⟩

Article dans une revue hal-03703786v1
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Two RFC1 splicing variants in CANVAS

Sacha Weber , Giulia Coarelli , Anna Heinzmann , Marie-Lorraine Monin , Nicolas Richard et al.

Brain - A Journal of Neurology , 2022, ⟨10.1093/brain/awac466⟩

Article dans une revue hal-03920011v1
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Motor neuron pathology in CANVAS due to RFC1 expansions

Vincent Huin , Giulia Coarelli , Clément Guemy , Susana Boluda , Rabab Debs et al.

Brain - A Journal of Neurology , 2021, pp.awab449. ⟨10.1093/brain/awab449⟩

Article dans une revue hal-03540380v1
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P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy

Kevin Carvalho , Elodie Martin , Aurélia Ces , Nadège Sarrazin , Pauline Lagouge-Roussey et al.

Progress in Neurobiology, 2021, 206, pp.102139. ⟨10.1016/j.pneurobio.2021.102139⟩

Article dans une revue inserm-03366671v1
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Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Ching-Pang Chang , Ya-Gin Chang , Pei-Yun Chuang , Thi Ngoc Anh Nguyen , Kuo-Chen Wu et al.

Acta Neuropathologica Communications, 2021, 9 (1), pp.112. ⟨10.1186/s40478-021-01213-7⟩

Article dans une revue inserm-03366697v1
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Reply: Two heterozygous Progranulin mutations in progressive supranuclear palsy

Vincent Huin , Mathieu Barbier , Alexandra Durr , Isabelle Le Ber

Brain - A Journal of Neurology , 2021, ⟨10.1093/brain/awaa456⟩

Article dans une revue hal-03113276v1
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Reply: Early-onset phenotype of bi-allelic GRN mutations

Vincent Huin , Mathieu Barbier , Alexandra Durr , Isabelle Le Ber

Brain - A Journal of Neurology , 2020, ⟨10.1093/brain/awaa415⟩

Article dans une revue hal-03113239v1
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Isolated parkinsonism is an atypical presentation of GRN and C9orf72 gene mutations Authors

Fábio Carneiro , Dario Saracino , Vincent Huin , Fabienne Clot , Cécile Delorme et al.

Parkinsonism & Related Disorders, 2020, 80, pp.73-81. ⟨10.1016/j.parkreldis.2020.09.019⟩

Article dans une revue hal-03146705v1
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Homozygous GRN mutations: unexpected phenotypes and new insights into pathological and molecular mechanisms

Vincent Huin , Mathieu Barbier , Armand Bottani , Johannes Alexander Lobrinus , Fabienne Clot et al.

Brain - A Journal of Neurology , 2020, 143 (1), pp.303-319. ⟨10.1093/brain/awz377⟩

Article dans une revue inserm-03014481v2
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The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals

Mégane Homa , Anne Loyens , Sabiha Eddarkaoui , Emilie Faivre , Vincent Deramecourt et al.

The Cerebellum, In press, Ahead of print. ⟨10.1007/s12311-020-01112-y⟩

Article dans une revue inserm-02463227v2
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Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases

Vincent Huin , Claire-Marie Dhaenens , Mégane Homa , Kévin Carvalho , Luc Buée et al.

Journal of Caffeine and Adenosine Research, 2019, 9 (3), pp.73-88. ⟨10.1089/caff.2019.0011⟩

Article dans une revue inserm-02460598v1
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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Kevin Carvalho , Emilie Faivre , Marie Pietrowski , Xavier Marques , Victoria Gomez-Murcia et al.

Brain - A Journal of Neurology , 2019, 142 (11), pp.3636-3654. ⟨10.1093/brain/awz288⟩

Article dans une revue inserm-02350065v1
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Expanding the phenotype of SCA19/22: Parkinsonism, cognitive impairment and epilepsy

Vincent Huin , Isabelle Strubi-Vuillaume , Kathy Dujardin , Marine Brion , Marie Delliaux et al.

Parkinsonism & Related Disorders, 2017, Parkinsonism & related disorders, 45, pp.85-89. ⟨10.1016/j.parkreldis.2017.09.014⟩

Article dans une revue hal-02467104v2
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Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer’s disease and progressive supranuclear palsy brains

Vincent Huin , Vincent Deramecourt , Dominique Caparros-Lefebvre , Claude Alain Maurage , Charles Duyckaerts et al.

Scientific Reports, 2017, 7 (1), pp.12589. ⟨10.1038/s41598-017-12955-7⟩

Article dans une revue inserm-02460428v1
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The MAPT gene is differentially methylated in the progressive supranuclear palsy brain

Vincent Huin , Vincent Deramecourt , Dominique Caparros-Lefebvre , Claude-Alain Maurage , Charles Duyckaerts et al.

Movement Disorders, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩

Article dans une revue istex hal-03015965v2

A geographical cluster of progressive supranuclear palsy in northern France

Dominique Caparros-Lefebvre , Lawrence I Golbe , Vincent Deramecourt , Claude-Alain Maurage , Vincent Huin et al.

Neurology, 2015, 85 (15), pp.1293-1300. ⟨10.1212/WNL.0000000000001997⟩

Article dans une revue inserm-02460488v1
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TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment

Jérôme Delplanque , David Devos , Vincent Huin , Alexandre Genet , Olivier Sand et al.

Brain - A Journal of Neurology , 2014, 137 (10), pp.2657-2663. ⟨10.1093/brain/awu202⟩

Article dans une revue inserm-03017555v1
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MBNL1 gene variants as modifiers of disease severity in myotonic dystrophy type 1

Vincent Huin , Francis Vasseur , Susanna Schraen-Maschke , Claire-Marie Dhaenens , Patrick Devos et al.

Journal of Neurology, 2013, 260 (4), pp.998-1003. ⟨10.1007/s00415-012-6740-y⟩

Article dans une revue istex hal-03555357v1
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Epigénomique du gène MAPT dans les tauopathies

Vincent Huin

Médecine humaine et pathologie. Université du Droit et de la Santé - Lille II, 2016. Français. ⟨NNT : 2016LIL2S030⟩

Thèse tel-01682414v1