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William Raoul

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Recrutement CR2 INSERM en CSS1 Neurosciences: 1er Octobre 2009 / Nomination CR1 INSERM en CSS6 Technologies pour la santé: 1er Janvier 2013 / Intégration de la CSS3 Physiologie et physiopathologie des grands systèmes: 1er Novembre 2019 **Diplômes** 2017 : Habilitation à Diriger des Recherches, Sciences de la Vie et de la Santé, Université François Rabelais de Tours. 2005 : Doctorat de Sciences de la Vie et de la Santé, Toxicologie, Université Paris XII-Créteil. 2001 : Diplôme d'études approfondies, Toxicologie, Université Paris V-Descartes. 2000 : Maîtrise de Biologie Cellulaire et Physiologie Animale, Université Paris XII-Créteil. **Laboratoires** 2019 - : Inserm UMR 1069 N2C, Nutrition Croissance Cancer, **Université** **de Tours** Directeur d’Unité : Christophe Vandier 2018 - 2019 : équipe PATCH, EA7501, **Université** **de Tours** Directeur d’équipe : Gilles Paintaud / Directeur d’Unité : Gilles Thibault 2013 - 2017 : équipe A2RC, CNRS UMR 7292, **Université** **François Rabelais, Tours** Directeur d’équipe : Gilles Paintaud / Directeur d’Unité : Gilles Paintaud 2012-2013 : équipe S14, INSERM UMR S 968, **Institut de la Vision, Paris** Directeur d’équipe : Florian Sennlaub / Directeur de l’Institut : José-Alain Sahel 2009-2011 : équipe 21, INSERM UMR S 872, **Centre de Recherche des Cordeliers, Paris** Directeur d’équipe : Florian Sennlaub / Directeur du Centre : Wolf Hervé Fridman 2006-2008 : équipe 17, INSERM UMR S 872, **Centre de Recherche des Cordeliers, Paris** Directeur d’équipe : Francine Behar-Cohen / Directeur du Centre : Wolf Hervé Fridman 2001-2005 : INSERM U651 (ex-U492), **Faculté de Médecine, Créteil** Directeur de Thèse : Bernard Maitre / Directeur d’Unité : Serge Adnot

Publications

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Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer

Maxime Guéguinou , Sajida Ibrahim , Jérôme Bourgeais , Alison Robert , Trayambak Pathak et al.
Cellular and Molecular Life Sciences, 2022, 79 (6), pp.article n° 284. ⟨10.1007/s00018-022-04311-4⟩
Journal articles hal-03668944v1
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New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation

Bruno Oyallon , Marie Brachet-Botineau , Cédric Logé , Thomas Robert , Stéphane Bach et al.
Molecules, 2021, 26 (4), pp.867. ⟨10.3390/molecules26040867⟩
Journal articles inserm-03272339v1
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A robust enzyme-linked immunosorbent assay to measure serum ramucirumab concentrations

Celine Desvignes , David Ternant , Thierry Lecomte , Astrid Lièvre , Marc Ohresser et al.
Bioanalysis, 2021, 13 (7), pp.565-574. ⟨10.4155/bio-2020-0199⟩
Journal articles inserm-03186974v1
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Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells

Romain Chautard , Laetitia Corset , Sajida Ibrahim , Céline Desvignes , Gilles Paintaud et al.
Biomarkers in Medicine, 2021, Online ahead of print. ⟨10.2217/bmm-2020-0520⟩
Journal articles inserm-03272360v1
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NCLX exchanger: An ambivalent role in colorectal cancer timeline

Maxime Guéguinou , Trayambak Pathak , Alison Robert , Christophe Vandier , Mohamed Trebak et al.
médecine/sciences, 2021, 37 (2), pp.124-126. ⟨10.1051/medsci/2020274⟩
Journal articles inserm-03144131v1
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L’échangeur ionique NCLX

Maxime Guéguinou , Trayambak Pathak , Alison Robert , Christophe Vandier , Mohamed Trebak et al.
médecine/sciences, 2021, 37 (2), pp.124-126. ⟨10.1051/medsci/2020274⟩
Journal articles hal-03143640v1
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SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer

Sajida Ibrahim , Justine Chaigne , Hassan Dakik , Yann Fourbon , Laetitia Corset et al.
Cell Calcium, 2021, 96, pp.102384. ⟨10.1016/j.ceca.2021.102384⟩
Journal articles inserm-03158756v1
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CD36 Deficiency Inhibits Retinal Inflammation and Retinal Degeneration in Cx3cr1 Knockout Mice

Sophie Lavalette , Sara Touhami , Christophe Roubeix , Marianne Houssier , Sébastien Augustin et al.
Frontiers in Immunology, 2020, 1, ⟨10.3389/fimmu.2019.03032⟩
Journal articles hal-02438587v1
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Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research

Marie Potier-Cartereau , William Raoul , Günther Weber , Karine Mahéo , Raphaël Rapetti-Mauss et al.
Reviews of Physiology Biochemistry and Pharmacology, 2020, Epub 2020 - 08 August. ⟨10.1007/112_2020_24⟩
Journal articles inserm-02921492v1
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Concurrent losses of skeletal muscle mass, adipose tissue and bone mineral density during bevacizumab / cytotoxic chemotherapy treatment for metastatic colorectal cancer

Adeline Dolly , Thierry Lecomte , Olivier Bouché , Christophe Borg , Eric Terrebonne et al.
Clinical Nutrition, 2020, S0261-5614 (20), pp.30080-7. ⟨10.1016/j.clnu.2020.02.017⟩
Journal articles inserm-02735513v1
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Mo-derived perivascular macrophage recruitment protects against endothelial cell death in retinal vein occlusion

Christophe Roubeix , Elisa Dominguez , William Raoul , Xavier Guillonneau , Michel Paques et al.
Journal of Neuroinflammation, 2019, 16 (1), ⟨10.1186/s12974-019-1547-8⟩
Journal articles inserm-02279956v1
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Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model

Diane Bressand , Anthony Novell , Alban Girault , William Raoul , Gaëlle Fromont-Hankard et al.
Molecular Pharmaceutics, 2019, 16 (9), pp.3814-3822. ⟨10.1021/acs.molpharmaceut.9b00416⟩
Journal articles hal-02301225v1
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micro-ARN et cancer colorectal

Romain Chautard , Sajida Ibrahim , Maxime Gueguinou , Thierry Lecomte , William Raoul et al.
Hépato-Gastro & Oncologie Digestive, 2019, ⟨10.1684/hpg.2019.1896⟩
Journal articles hal-02438640v1
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Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer

Sajida Ibrahim , Hassan Dakik , Christophe Vandier , Romain Chautard , Gilles Paintaud et al.
Cancers, 2019, 11 (4), pp.561. ⟨10.3390/cancers11040561⟩
Journal articles inserm-02152189v1
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Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans

David Ternant , Nicolas Azzopardi , William Raoul , Theodora Bejan-Angoulvant , Gilles Paintaud et al.
Clinical Pharmacokinetics, inPress, ⟨10.1007/s40262-018-0680-3⟩
Journal articles hal-01821717v1
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Pharmacokinetics partly explains the relationship between carcinoembryonic antigen level and survival of colorectal cancer patients treated with ramucirumab

Sajida Ibrahim , William Raoul , Thierry Lecomte , Gilles Paintaud , David Ternant et al.
European Journal of Cancer, 2018, 92, pp.119 - 120. ⟨10.1016/j.ejca.2017.12.004⟩
Journal articles inserm-01755511v1
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Drug Efficacy Monitoring in Pharmacotherapy of Multiple Sclerosis with Biological Agents

Marzia Caldano , William Raoul , Theo Rispens , Antonio Bertolotto
Therapeutic Drug Monitoring, 2017, 39 (4), pp.350 - 355. ⟨10.1097/FTD.0000000000000393⟩
Journal articles inserm-01755556v1
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Monoclonal Antibodies Targeting the IL-17/IL-17RA Axis: An Opportunity to Improve the Efficiency of Anti-VEGF Therapy in Fighting Metastatic Colorectal Cancer?

Sajida Ibrahim , Alban Girault , Marc Ohresser , Emilie Lereclus , Gilles Paintaud et al.
Clinical Colorectal Cancer, 2017, ⟨10.1016/j.clcc.2017.10.003⟩
Journal articles inserm-01661759v1
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Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

Bertrand Calippe , Sébastien Augustin , Fanny Beguier , Hugo Charles-Messance , Lucie Poupel et al.
Immunity, 2017, 46 (2), pp.261 - 272. ⟨10.1016/j.immuni.2017.01.006⟩
Journal articles inserm-01755551v1
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Méthodes d'évaluation de la cicatrisation muqueuse des maladies inflammatoires chroniques de l'intestin (MICI)

Julie Auzoux , Gilles Boschetti , Widad Lahlou , Alexandre Aubourg , Alban Girault et al.
Hépato-Gastro & Oncologie Digestive, 2017
Journal articles hal-02438672v1
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A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen

Emilie Lereclus , Mira Tout , Alban Girault , Nadine Baroukh , Morgane Caulet et al.
BMC Cancer, 2016, 17 (1), pp.220. ⟨10.1186/s12885-017-3210-z⟩
Journal articles inserm-01661765v1
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Association of choroidal IL-17-producing T lymphocytes and macrophages with geographic atrophy

Serge Camelo , Sophie Lavalette , Xavier Guillonneau , William Raoul , Florian Sennlaub et al.
Ophthalmologica, 2016, 236 (1), pp.53-58. ⟨10.1159/000446587⟩
Journal articles inserm-01499605v1
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Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration

Olivier Levy , Bertrand Calippe , Sophie Lavalette , Shulong J Hu , William Raoul et al.
EMBO Molecular Medicine, 2015, 7 (2), pp.211-26. ⟨10.15252/emmm.201404524⟩
Journal articles inserm-01231055v1
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Experimental Branch Retinal Vein Occlusion Induces Upstream Pericyte Loss and Vascular Destabilization

Elisa Dominguez , William Raoul , Bertrand Calippe , José-Alain Sahel , Xavier Guillonneau et al.
PLoS ONE, 2015, 10 (7), pp.e0132644. ⟨10.1371/journal.pone.0132644.g006⟩
Journal articles inserm-01231103v1
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APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration

Olivier Levy , Sophie Lavalette , Shulong Hu , Michael Housset , William Raoul et al.
Journal of Neuroscience, 2015, 35 (40), pp.13568-13576. ⟨10.1523/JNEUROSCI.2468-15.2015⟩
Journal articles hal-02301206v1
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Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice

Serge Camelo , Bertrand Calippe , Sophie Lavalette , Elisa Dominguez , Justine Hur et al.
Molecular Vision, 2015, 21, pp.1051-9
Journal articles inserm-01231077v1
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Protease nexin-1 regulates retinal vascular development

Sonia Selbonne , Deborah Francois , William Raoul , Yacine Boulaftali , Florian Sennlaub et al.
Cellular and Molecular Life Sciences, 2015, 72 (20), pp.3999-4011. ⟨10.1007/s00018-015-1972-5⟩
Journal articles inserm-01231082v1
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Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histology.

Adeline Berger , Sophie Cavallero , Elisa Dominguez , Peggy Barbe , Manuel Simonutti et al.
PLoS ONE, 2014, 9 (5), pp.e96494. ⟨10.1371/journal.pone.0096494⟩
Journal articles hal-00990132v1
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Neonatal Hyperglycemia Inhibits Angiogenesis and Induces Inflammation and Neuronal Degeneration in the Retina

Elsa Kermorvant-Duchemin , Alexis Christophe Pinel , Sophie Lavalette , Delphine Lenne , William Raoul et al.
PLoS ONE, 2013, 8 (11), pp.e79545. ⟨10.1371/journal.pone.0079545⟩
Journal articles hal-02301188v1
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Comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration" by Luhmann et al. (Exp. Eye Res. 2013; 107: 80.doi: 10.1016).

Christophe Combadière , William Raoul , Xavier Guillonneau , Florian Sennlaub
Experimental Eye Research, 2013, 111, pp.134-5. ⟨10.1016/j.exer.2013.02.002⟩
Journal articles inserm-00990798v1
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CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.

Florian Sennlaub , Constance Auvynet , Bertrand Calippe , Sophie Lavalette , Lucie Poupel et al.
EMBO Molecular Medicine, 2013, 5 (11), pp.1775-93. ⟨10.1002/emmm.201302692⟩
Journal articles inserm-00912837v1
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MFGE8 Does Not Influence Chorio-Retinal Homeostasis or Choroidal Neovascularization in vivo.

William Raoul , Lucie Poupel , David-Alexandre Tregouet , Sophie Lavalette , Serge Camelo et al.
PLoS ONE, 2012, 7 (3), pp.e33244. ⟨10.1371/journal.pone.0033244⟩
Journal articles inserm-00690728v1
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Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.

Serge Camelo , William Raoul , Sophie Lavalette , Bertrand Calippe , Brunella Cristofaro et al.
Angiogenesis, 2012, 15 (4), pp.609-22. ⟨10.1007/s10456-012-9290-0⟩
Journal articles inserm-00853034v1
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Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration.

Sophie Lavalette , William Raoul , Marianne Houssier , Serge Camelo , Olivier Levy et al.
American Journal of Pathology, 2011, 178 (5), pp.2416-23. ⟨10.1016/j.ajpath.2011.01.013⟩
Journal articles inserm-00690746v1
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CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.

William Raoul , Constance Auvynet , Serge Camelo , Xavier Guillonneau , Charles Feumi et al.
Journal of Neuroinflammation, 2010, 7, pp.87. ⟨10.1186/1742-2094-7-87⟩
Journal articles inserm-00610572v2
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Toxoplasma gondii: Flat-mounting of retina as a new tool for the observation of ocular infection in mice

Patricia Escoffier , Jean-Claude Jeanny , Carine Marinach-Patrice , Laurent Jonet , William Raoul et al.
Experimental Parasitology, 2010, pp.259-262. ⟨10.1016/j.exppara.2010.04.006⟩
Journal articles inserm-01094666v1
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Rôles des chimiokines dans le développement de la dégénérescence maculaire liée à l’âge

William Raoul , Elise C. Lelièvre , Constance Auvynet , Charles Feumi , Christophe Combadière et al.
Biologie Aujourd'hui, 2010, 204 (4), pp.311-319. ⟨10.1051/jbio/2010024⟩
Journal articles hal-02301154v1
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Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells.

William Raoul , Nicole Keller , Mathieu Rodéro , Francine Behar-Cohen , Florian Sennlaub et al.
Journal of Neuroimmunology, 2008, 198 (1-2), pp.56-61. ⟨10.1016/j.jneuroim.2008.04.014⟩
Journal articles inserm-00311574v1
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Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice.

William Raoul , Charles Feumi , Nicole Keller , Sophie Lavalette , Marianne Houssier et al.
Ophthalmic Research, 2008, 40 (3-4), pp.115-9. ⟨10.1159/000119860⟩
Journal articles inserm-00315944v1

Polymorphism in the Microglial Cell-Mobilizing CX3CR1 Gene Is Associated With Survival in Patients With Glioblastoma

Mathieu Rodéro , Yannick Marie , Mathieu Coudert , Emmeline Blondet , Karima Mokhtari et al.
Journal of Clinical Oncology, 2008, 26 (36), pp.5957-5964. ⟨10.1200/JCO.2008.17.2833⟩
Journal articles hal-02301138v1
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CD36 Deficiency Leads to Choroidal Involution via COX2 Down-Regulation in Rodents.

Marianne Houssier , William Raoul , Sophie Lavalette , Nicole Keller , Xavier Guillonneau et al.
PLoS Medicine, 2008, 5 (2), pp.e39. ⟨10.1371/journal.pmed.0050039⟩
Journal articles inserm-00258554v1
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Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.

Esma Lejmi , Laurence Leconte , Sandrine Pédron-Mazoyer , Stanislas Ropert , William Raoul et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (34), pp.12491-6. ⟨10.1073/pnas.0804008105⟩
Journal articles inserm-00315946v1
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Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.

William Raoul , Orianne Wagner-Ballon , Guitanouch Saber , Anne Hulin , Elisabeth Marcos et al.
Respiratory Research, 2007, 8, pp.8. ⟨10.1186/1465-9921-8-8⟩
Journal articles inserm-00130570v1
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CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

Christophe Combadière , Charles Feumi , William Raoul , Nicole Keller , Mathieu Rodéro et al.
Journal of Clinical Investigation, 2007, 117 (10), pp.2920-2928. ⟨10.1172/JCI31692⟩
Journal articles inserm-00176389v1
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Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.

Christophe Guignabert , Bernadette Raffestin , Rima Benferhat , William Raoul , Patricia Zadigue et al.
Circulation, 2005, 111 (21), pp.2812-9. ⟨10.1161/CIRCULATIONAHA.104.524926⟩
Journal articles inserm-00499643v1
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Adenovirus-mediated fibroblast growth factor 1 expression in the lung induces epithelial cell proliferation: consequences to hyperoxic lung injury in rats.

Vanessa Louzier , William Raoul , Aude Leroux , Didier Branellec , Jean-Michel Caillaud et al.
Human Gene Therapy, 2004, 15 (8), pp.793-804. ⟨10.1089/1043034041648390⟩
Journal articles inserm-00990784v1
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Effects of vascular endothelial growth factor on isolated fetal alveolar type II cells

William Raoul , Bernadette Chailley-Heu , Anne-Marie Barlier-Mur , Christophe Delacourt , Bernard Maitre et al.
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2004, 286 (6), pp.L1293 - L1301. ⟨10.1152/ajplung.00157.2003⟩
Journal articles inserm-01755344v1
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Lung Overexpression of Angiostatin Aggravates Pulmonary Hypertension in Chronically Hypoxic Mice

Marie-Aude Pascaud , Frank Griscelli , William Raoul , Elisabeth Marcos , Paule Opolon et al.
American Journal of Respiratory Cell and Molecular Biology, 2003, 29, pp.449 - 457. ⟨10.1165/rcmb.2002-0120OC⟩
Journal articles inserm-01094673v1