Xiaojing Cong

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Publications

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A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light

Anaëlle Dumazer , Roser Borras-Tuduri , Iona Truong , Xiaojing Cong , Fanny Malhaire et al.

Biochemical Pharmacology, 2025, 240, pp.117065. ⟨10.1016/j.bcp.2025.117065⟩

Article dans une revue hal-05140566v1
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Conformational dynamics underlying atypical chemokine receptor 3 activation

Omolade Otun , Christelle Aljamous , Elise Del Nero , Marta Arimont-Segura , Reggie Bosma et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (30), pp.e2404000121. ⟨10.1073/pnas.2404000121⟩

Article dans une revue hal-04731883v1
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Biased activation of the vasopressin V2 receptor probed by NMR, paramagnetic ligands, and molecular dynamics simulations

Aurelien Fouillen , Pierre Couvineau , Gérald Gaibelet , Stéphanie Riché , Hélène Orcel et al.

Computational and Structural Biotechnology Journal, 2024, 23, pp.3784-3799. ⟨10.1016/j.csbj.2024.10.039⟩

Article dans une revue hal-03756232v2

The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

Sarah Erlandson , Shaun Rawson , James Osei-Owusu , Kelly Brock , Xinyue Liu et al.

Nature Chemical Biology, 2023, 19 (8), pp.1013-1021. ⟨10.1038/s41589-023-01321-6⟩

Article dans une revue hal-04284543v1
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Structure of the vasopressin hormone–V2 receptor–β-arrestin1 ternary complex

Julien Bous , Aurélien Fouillen , Hélène Orcel , Stefano Trapani , Xiaojing Cong et al.

Science Advances , 2022, 8 (35), pp.eabo7761. ⟨10.1126/sciadv.abo7761⟩

Article dans une revue hal-03790728v1
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Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

Paul Lambey , Omolade Otun , Xiaojing Cong , François Hoh , Luc Brunel et al.

eLife, 2022, 11, pp.e72555. ⟨10.7554/eLife.72555⟩

Article dans une revue hal-03754372v1
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The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding

Tammy Shim , Jody Pacalon , Won-Cheol Kim , Xiaojing Cong , Jérémie Topin et al.

International Journal of Molecular Sciences, 2022, 23 (20), pp.12501. ⟨10.3390/ijms232012501⟩

Article dans une revue hal-04712540v1

Interactions among key residues regulate mammalian odorant receptor trafficking

Rui Xu , Xiaojing Cong , Qian Zheng , Lun Xu , Mengjue Ni et al.

FASEB Journal, 2022, 36 (7), pp.e22384. ⟨10.1096/fj.202200116RR⟩

Article dans une revue hal-04724118v1

Discovery and mechanism of action of small molecule inhibitors of ceramidases

Robert Healey , Essa Saied , Xiaojing Cong , Gergely Karsai , Ludovic Gabellier et al.

Angewandte Chemie International Edition, 2022, 61 (2), pp.e202109967. ⟨10.1002/anie.202109967⟩

Article dans une revue hal-03406152v1
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Extracellular loop 2 of G protein-coupled olfactory receptors is critical for odorant recognition

Yiqun Yu , Zhenjie Ma , Jody Pacalon , Lun Xu , Weihao Li et al.

Journal of Biological Chemistry, 2022, 298 (9), pp.102331. ⟨10.1016/j.jbc.2022.102331⟩

Article dans une revue hal-03749290v1

Large-Scale G Protein-Coupled Olfactory Receptor–Ligand Pairing

Xiaojing Cong , Wenwen Ren , Jody Pacalon , Rui Xu , Lun Xu et al.

ACS Central Science, 2022, 8 (3), pp.379-387. ⟨10.1021/acscentsci.1c01495⟩

Article dans une revue hal-05505442v1
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An automated platform for structural analysis of membrane proteins through serial crystallography

Robert Healey , Shibom Basu , Anne-Sophie Humm , Cedric Leyrat , Xiaojing Cong et al.

Cell Reports Methods, 2021, 1 (6), pp.100102. ⟨10.1016/j.crmeth.2021.100102⟩

Article dans une revue hal-03414080v1
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Molecular insights into the biased signaling mechanism of the μ-opioid receptor

Xiaojing Cong , Damien Maurel , Héléne Démèné , Ieva Vasiliauskaité-Brooks , Joanna Hagelberger et al.

Molecular Cell, In press, 81 (20), pp.4165-4175.e6. ⟨10.1016/j.molcel.2021.07.033⟩

Article dans une revue hal-03331072v1

Allosteric Modulation Mechanism of the mGluR 5 Transmembrane Domain

Xiaojing Cong , Jean-Baptiste Chéron , Jérôme Golebiowski , Serge Antonczak , Sébastien Fiorucci

Journal of Chemical Information and Modeling, 2019, ⟨10.1021/acs.jcim.9b00045⟩

Article dans une revue hal-02137256v1

Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts

Xiaojing Cong , Qian Zheng , Wenwen Ren , Jean-Baptiste Chéron , Sébastien Fiorucci et al.

Journal of Biological Chemistry, 2019, 294 (17), pp.6762-6771. ⟨10.1074/jbc.RA118.006483⟩

Article dans une revue hal-02545194v1

Activation Dynamics of the Neurotensin G Protein-Coupled Receptor 1

Xiaojing Cong , Sébastien Fiorucci , Jérôme Golebiowski

Journal of Chemical Theory and Computation, 2018, 14 (8), pp.4467-4473. ⟨10.1021/acs.jctc.8b00216⟩

Article dans une revue hal-02545198v1

The Functional Role of the Third Extracellular Loop of Mammalian Odorant Receptors in Ligand Binding

Tammy Shim , Jody Pacalon , Woncheol Kim , Xiaojing Cong , Jérémie Topin et al.

XLVth Annual Meeting of the Association for Chemoreception Sciences, AChemS, Apr 2023, Bonita Springs (Floride), United States. Oxford University Press, Chemical Senses, 48, pp.121, bjad029.279, 2024

Poster de conférence hal-04730776v1