zoubida karim

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Editorial: Ironome: a still untapped frontier

Gloria C Ferreira , Vladimir N Uversky , Zoubida Karim

Frontiers in Molecular Biosciences, 2025, 12, pp.1651154. ⟨10.3389/fmolb.2025.1651154⟩

Article dans une revue hal-05378482v1
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Identification of a neuron-specific ferroptosis in the neurodegenerative mucopolysaccharidosis III model

Mathilde Larribau , Myriam Rouahi , Christophe Santiago , Jérôme Ausseil , Zoubida Karim

Frontiers in Molecular Biosciences, 2025, 12, pp.1476513. ⟨10.3389/fmolb.2025.1476513⟩

Article dans une revue hal-05376668v1

Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation

Marion Falabrègue , Candice Aurrand , Léa Cazaulon , Nadia Boussetta , Sara Zumerle et al. Article dans une revue hal-05347161v1
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Iron and energy metabolic interactions in Treg-mediated immune regulation

Frédérique Savagner , Thomas Farge , Zoubida Karim , Meryem Aloulou

Frontiers in Immunology, 2025, 16, pp.1554028. ⟨10.3389/fimmu.2025.1554028⟩

Article dans une revue hal-05378486v1
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Cutaneous leishmaniasis and iron metabolism: current insights and challenges

Aicha Assouab , Ayyoub Kihel , Myriam Rouahi , Mathilde Larribau , Zoubida Karim et al.

Frontiers in Immunology, 2024, 15, pp.1488590. ⟨10.3389/fimmu.2024.1488590⟩

Article dans une revue hal-05045859v1
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Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment

Elise Abboud , Doha Chrayteh , Nadia Boussetta , Héloise Dalle , Mariangela Malerba et al.

Nature Communications, 2024, 15, pp.6718. ⟨10.1038/s41467-024-50993-8⟩

Article dans une revue hal-05045889v1
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IRE-dependent Regulation of Intestinal Dmt1 Prevails During Chronic Dietary Iron Deficiency but is Dispensable in Conditions of Acute Erythropoietic Stress

Maria Qatato , Michael Bonadonna , Gaël Palais , Alina Ertl , Gabriele Schmidt et al.

HemaSphere, 2022, 6 (3), pp.e693. ⟨10.1097/HS9.0000000000000693⟩

Article dans une revue inserm-03874988v1
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Crosstalk between Acidosis and Iron Metabolism: Data from In Vivo Studies

Raêd Daher , Nicolas Ducrot , Thibaud Lefebvre , Sofia Zineeddine , Jérome Ausseil et al.

Metabolites, 2022, 12 (2), pp.89. ⟨10.3390/metabo12020089⟩

Article dans une revue inserm-03874980v1
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Kinetics of serum hepcidin and interleukin-6 levels following COVID-19 infection in hemodialysis patients

Maxime Touzot , Thibaud Lefebvre , Catherine Maheas , Katell Peoc'H , Pablo Ureña-Torres et al.

Clinical Kidney Journal, 2022, 15 (3), pp.582-583. ⟨10.1093/ckj/sfab254⟩

Article dans une revue hal-03764736v1

Luspatercept (RAP-536) modulates oxidative stress without affecting mutation burden in myelodysplastic syndromes

Meunier Mathieu , Chloé Friedrich , Nicolas Ducrot , Johanna Zannoni , Tondeur Sylvie et al.

Annals of Hematology, 2022, 101 (12), pp.2633-2643. ⟨10.1007/s00277-022-04993-7⟩

Article dans une revue inserm-03874959v1
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ABCB6 Polymorphisms are not Overly Represented in Patients with Porphyria

Colin P Farrell , Gaël Nicolas , Robert Desnick , Charles J Parker , Jerome Lamoril et al.

Blood Advances, 2022, 6 (3), pp.760-766. ⟨10.1182/bloodadvances.2021005484⟩

Article dans une revue hal-03483658v2

Prevalence of HFE-related haemochromatosis and secondary causes of hyperferritinaemia and their association with iron overload in 1059 French patients treated by venesection

Gérald Le Gac , Virginie Scotet , Isabelle Gourlaouen , Carine L'Hostis , Marie-Christine Merour et al.

Alimentary Pharmacology & Therapeutics, 2022, 55 (8), pp.1016-1027. ⟨10.1111/apt.16775⟩

Article dans une revue hal-03592561v1
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Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy

Thibaud Lefebvre , Muriel Coupaye , Marina Esposito-Farèse , Nathalie Gault , Neila Talbi et al.

Nutrients, 2021, 13 (8), pp.2516. ⟨10.3390/nu13082516⟩

Article dans une revue hal-03448937v1

A hepcidin‐based approach for iron therapy in hemodialysis patients: A pilot study

Maxime Touzot , Thibaud Lefebvre , Catherine Maheas , Christophe Ridel , Hervé Puy et al.

Hemodialysis International, 2020, 24 (2), pp.188-194. ⟨10.1111/hdi.12823⟩

Article dans une revue hal-03046316v1

Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria

Jean-Marc Blouin , Cécile Ged , Magalie Lalanne , Isabelle Lamrissi-Garcia , Fanny Morice-Picard et al.

Blood, 2020, 136 (21), pp.2457-2468. ⟨10.1182/blood.2020006037⟩

Article dans une revue hal-03045807v1
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Control of Systemic Iron Homeostasis by the 3’ Iron-Responsive Element of Divalent Metal Transporter 1 in Mice

Elisabeth Tybl , Hiromi Gunshin , Sanjay Gupta , Tomasa Barrientos , Michael Bonadonna et al.

HemaSphere, 2020, 4 (5), pp.e459. ⟨10.1097/HS9.0000000000000459⟩

Article dans une revue hal-03043109v1
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GLRX5 mutations impair heme biosynthetic enzymes ALA synthase 2 and ferrochelatase in Human congenital sideroblastic anemia

Raed Daher , Abdellah Mansouri , Alain Martelli , Sophie Bayart , Hana Manceau et al.

Molecular Genetics and Metabolism, 2019, ⟨10.1016/j.ymgme.2018.12.012⟩

Article dans une revue hal-02351427v1
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A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome

Sabrina Bondu , Anne-Sophie Alary , Carine Lefevre , Alexandre Houy , Grace Jung et al.

Science Translational Medicine, 2019, 11 (500), pp.eaav5467. ⟨10.1126/scitranslmed.aav5467⟩

Article dans une revue inserm-02449216v1

Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias

Katell Peoc'H , Gaël Nicolas , Caroline Schmitt , Arienne Mirmiran , Raed Daher et al.

Molecular Genetics and Metabolism, 2019, ⟨10.1016/j.ymgme.2019.01.015⟩

Article dans une revue hal-02351175v1

Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria)

Thibaud Lefebvre , Sarah Millot , Emmanuel Richard , Jean-Marc Blouin , Magalie Lalanne et al.

Biochemical and Biophysical Research Communications, 2019, 520 (2), pp.297-303. ⟨10.1016/j.bbrc.2019.09.141⟩

Article dans une revue hal-03046353v1

Extrahepatic hepcidin production: The intriguing outcomes of recent years

Raêd Daher , Thibaud Lefebvre , Hervé Puy , Zoubida Karim

World Journal of Clinical Cases, 2019, 7 (15), pp.1926-1936. ⟨10.12998/wjcc.v7.i15.1926⟩

Article dans une revue hal-03046342v1

Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1

Sarah Rio , Marc Gastou , Narjesse Karboul , Raphaёl Derman , Thunwarat Suriyun et al.

Blood, 2019, 133 (12), pp.1358-1370. ⟨10.1182/blood-2018-09-875674⟩

Article dans une revue hal-02339695v1

Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias

Katell Peoc'H , Gaël Nicolas , Caroline Schmitt , Arienne Mirmiran , Raed Daher et al.

Molecular Genetics and Metabolism, 2019, ⟨10.1016/j.ymgme.2019.01.015⟩

Article dans une revue inserm-02075450v1

Functional erythropoietin‐hepcidin axis in recombinant human erythropoietin independent haemodialysis patients

Maxime Touzot , Thibaud Lefebvre , Arthur Roux , Catherine Maheas , Christophe Ridel et al.

Nephrology, 2019, 24 (7), pp.751-757. ⟨10.1111/nep.13485⟩

Article dans une revue hal-02351435v1

Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria)

Zoubida Karim

Biochemical and Biophysical Research Communications, In press, ⟨10.1016/j.bbrc.2019.09.141⟩

Article dans une revue hal-02350852v1
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Dyserythropoiesis evaluated by the RED score and hepcidin:ferritin ratio predicts response to erythropoietin in lower-risk myelodysplastic syndromes

Sophie Park , Olivier Kosmider , Fréderic Maloisel , Bernard Drénou , Nicolas Chapuis et al.

Haematologica, 2019, 104 (3), pp.497-504. ⟨10.3324/haematol.2018.203158⟩

Article dans une revue hal-02351432v1

Erythroid-Progenitor-Targeted Gene Therapy Using Bifunctional TFR1 Ligand-Peptides in Human Erythropoietic Protoporphyria

Arienne Mirmiran , Caroline Schmitt , Thibaud Lefebvre , Hana Manceau , Raed Daher et al.

American Journal of Human Genetics, 2019, 104 (2), pp.341-347. ⟨10.1016/j.ajhg.2018.12.021⟩

Article dans une revue hal-02328937v1

Extrahepatic hepcidin production: The intriguing outcomes of recent years

Raed Daher , Thibaud Lefebvre , Hervé Puy , Zoubida Karim

World Journal of Clinical Cases, 2019, 7 (15), pp.1926-1936. ⟨10.12998/wjcc.v7.i15.1926⟩

Article dans une revue hal-02350928v1
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The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls

Camille Petillon , Rudolf Hergesheimer , Hervé Puy , Philippe Corcia , Patrick Vourc’h et al.

Frontiers in Neuroscience, 2019, 12, pp.1031. ⟨10.3389/fnins.2018.01031⟩

Article dans une revue hal-02351424v1
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Hepatocellular carcinoma in acute hepatic porphyrias: A Damocles Sword

Katell Peoc'H , Hana Manceau , Zoubida Karim , Staffan Wahlin , Laurent Gouya et al.

Molecular Genetics and Metabolism, 2018, ⟨10.1016/j.ymgme.2018.10.001⟩

Article dans une revue hal-02351428v1

Porphyria and kidney diseases

Nicolas Pallet , Alexandre Karras , Eric Thervet , Laurent Gouya , Zoubida Karim et al.

Clinical Kidney Journal, 2018, 11 (2), pp.191-197. ⟨10.1093/ckj/sfx146⟩

Article dans une revue hal-02351440v1
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Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease

Thibaud Lefebvre , Niloofar Reihani , Raed Daher , Thierry Billette de Villemeur , Nadia Belmatoug et al.

Haematologica, 2018, 103 (4), pp.587-596. ⟨10.3324/haematol.2017.177816⟩

Article dans une revue hal-01762401v1
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Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver

Caroline Schmitt , Hugo Lenglet , Angèle Yu , Constance Delaby , Arndt Benecke et al.

Journal of Internal Medicine, 2018, 284 (1), pp.78-91. ⟨10.1111/joim.12750⟩

Article dans une revue hal-02503870v1

Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease

Vincent Puy , Walaa Darwiche , Stephanie Trudel , Cathy Gomila , Christelle Lony et al.

Glia, 2018, 66 (8), pp.1709-1723. ⟨10.1002/glia.23335⟩

Article dans une revue hal-02351442v1

From a dominant to an oligogenic model of inheritance with environmental modifiers in acute intermittent porphyria

Hugo Lenglet , Caroline Schmitt , Thomas Grange , Hana Manceau , Narjesse Karboul et al.

Human Molecular Genetics, 2018, 27 (7), pp.1164-1173. ⟨10.1093/hmg/ddy030⟩

Article dans une revue hal-02351445v1
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Cardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome

Mariane de Montalembert , Jean-Antoine Ribeil , Valentine Brousse , Agnès Guerci-Bresler , Aspasia Stamatoullas et al.

PLoS ONE, 2017, 12 (3), pp.e0172147. ⟨10.1371/journal.pone.0172147⟩

Article dans une revue hal-02377929v1
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Mutation in human CLPX elevates levels of δ- aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria

Yvette Yien , Sarah Ducamp , Lisa van Der Vorm , Julia Kardon , Hana Manceau et al.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (38), pp.E8045-E8052. ⟨10.1073/pnas.1700632114⟩

Article dans une revue inserm-02075468v1

Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease

Raed Daher , Hana Manceau , Zoubida Karim

La Presse Médicale, 2017, 46 (12), pp.e272-e278. ⟨10.1016/j.lpm.2017.10.006⟩

Article dans une revue hal-02351459v1

Corrigendum to “Alteration of cerebral iron metabolism in Sanfilippo syndrome” [Mol. Genet. Metab. 117 2, February 2016, p. S97]

Vincent Puy , Pierre-Edouard Bodet , Camille Rottier , Rémi Delaunay , Cathy Gomila et al.

Molecular Genetics and Metabolism, 2016, 118 (1), pp.64. ⟨10.1016/j.ymgme.2016.03.005⟩

Article dans une revue hal-02065247v1
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Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans

Raed Daher , Caroline Kannengiesser , Dounia Houamel , Thibaud Lefebvre , Edouard Bardou-Jacquet et al.

Gastroenterology, 2016, 150 (3), pp.672-683. ⟨10.1053/j.gastro.2015.10.049⟩

Article dans une revue hal-01231430v1

The microbiota shifts the iron sensing of intestinal cells

Jean-Christophe Deschemin , Marie-Louise M.-L. Noordine , Aude Remot , Alexandra Willemetz , Clément Afif et al.

FASEB Journal, 2016, 30 (1), pp.252-261. ⟨10.1096/fj.15-276840⟩

Article dans une revue hal-02632319v1

Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria

Chadi Homedan , Caroline Schmitt , Jihane Laafi , Naïg Gueguen , Valérie Desquiret-Dumas et al.

Human Molecular Genetics, 2015, 24 (17), pp.5015-23. ⟨10.1093/hmg/ddv222⟩

Article dans une revue hal-02056592v1

Iron Regulatory Protein 1 Sustains Mitochondrial Iron Loading and Function in Frataxin Deficiency

Alain Martelli , Stephane Schmucker , Laurence Reutenauer , Jacques R.R. Mathieu , Carole Peyssonnaux et al.

Cell Metabolism, 2015, 21 (2), pp.311-323. ⟨10.1016/j.cmet.2015.01.010⟩

Article dans une revue hal-04996861v1
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High prevalence of and potential mechanisms for chronic kidney disease in patients with acute intermittent porphyria

Nicolas Pallet , Iadh Mami , Caroline Schmitt , Zoubida Karim , Arnaud François et al.

Kidney International, 2015, 88 (2), pp.386-395. ⟨10.1038/ki.2015.97⟩

Article dans une revue hal-02317945v1

Acute intermittent porphyria causes hepatic mitochondrial energetic failure in a mouse model

Chadi Homedan , Jihane Laafi , Caroline Schmitt , Naïg Gueguen , Thibaud Lefebvre et al.

International Journal of Biochemistry and Cell Biology, 2014, 51, pp.93-101. ⟨10.1016/j.biocel.2014.03.032⟩

Article dans une revue istex hal-03328708v1

Protoporphyrin retention in hepatocytes and kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model.

Saïd Lyoumi , Marie Abitbol , Dominique Rainteau , Zoubida Karim , Florence Bernex et al.

Gastroenterology, 2011, 141 ((4)), pp.1509-1519.e3. ⟨10.1053/j.gastro.2011.06.078⟩

Article dans une revue hal-00631510v1