Alain Bousquet-Mélou

252
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Affiliations actuelles
  • Innovations Thérapeutiques et Résistances (InTheRes)
  • Innovations Thérapeutiques et Résistances (InTheRes)
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Publications

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Publications

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Pharmacokinetic–Pharmacodynamic Cutoff Values for Doxycycline in Pigs to Support the Establishment of Clinical Breakpoints for Antimicrobial Susceptibility Testing

Pierre‐louis Toutain , Alain Bousquet‐melou , Aude A Ferran , Béatrice B Roques , Jérôme R E del Castillo et al.
Journal of Veterinary Pharmacology and Therapeutics, 2025, ⟨10.1111/jvp.13511⟩
Article dans une revue hal-05046560 v1
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Presencia de residuos antibióticos en carnes comercializadas en el área transfronteriza España‑Francia: un enfoque novedoso en los métodos de vigilancia

María Jesús Serrano , Janira Elorduy , Itsaso Zabaleta , Georges Istamboulie , Elena González-Fandos et al.
ITEA, información técnica económica agraria: revista de la Asociación Interprofesional para el Desarrollo Agrario (AIDA), 2024, 120 (3), pp.251-268. ⟨10.12706/itea.2024.001⟩
Article dans une revue hal-04682445 v1

Potentialities of semi-continuous anaerobic digestion for mitigating antibiotics in sludge

Amine Ezzariai , Julie Jimenez , Maialen Barret , David Riboul , Marlène Z Lacroix et al.
Environmental Science and Pollution Research, 2024, 31, pp.66067-66078. ⟨10.1007/s11356-024-35664-x⟩
Article dans une revue hal-04886552 v1
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Antimicrobial combinations against <i>Helicobacter pylori</i> including benzoxadiazol-based flavodoxin inhibitors: <i>in vitro</i> characterization

Lilha Beyria , Ophelie Gourbeyre , Sandra Salillas , Alejandro Mahía , María Dolores Díaz de Villegas et al.
Microbiology Spectrum, 2024, 12 (1), ⟨10.1128/spectrum.02623-23⟩
Article dans une revue hal-04352359 v1
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Development of an in vitro biofilm model for the study of the impact of fluoroquinolones on sewer biofilm microbiota

Sarah A Naudin , Aude A Ferran , Pedro Henrique Imazaki , Nathalie Arpaillange , Camille Marcuzzo et al.
Frontiers in Microbiology, 2024, 15, ⟨10.3389/fmicb.2024.1377047⟩
Article dans une revue hal-04522705 v1
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The sub-MIC selective window decreases along the digestive tract: determination of the minimal selective concentration of oxytetracycline in sterilised intestinal contents

Pedro Henrique Imazaki , Bertille Voisin , Béatrice Roques , Emilie Dordet-Frisoni , Véronique Dupouy et al.
Frontiers in Microbiology, 2024, 15 (22), pp.1803-1804. ⟨10.3389/fmicb.2024.1377159⟩
Article dans une revue hal-04700337 v1
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Comparative bactericidal activity of four macrolides alone and combined with rifampicin or doxycycline against Rhodococcus equi at concentrations achievable in foals

Anne-Sophie Huguet , Ophélie Gourbeyre , Agathe Bernand , Charline Philibert , Alain Bousquet-Melou et al.
Frontiers in Pharmacology, 2024, 15, pp.1458496. ⟨10.3389/fphar.2024.1458496⟩
Article dans une revue hal-04816942 v1
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Predicted efficacy and tolerance of different dosage regimens of benzylpenicillin in horses based on a pharmacokinetic study with three IM formulations and one IV formulation

Aude A. Ferran , Béatrice Roques , Laura Chapuis , Taisuke Kuroda , Marlène Lacroix et al.
Frontiers in Veterinary Science, 2024, 11, pp.1409266. ⟨10.3389/fvets.2024.1409266⟩
Article dans une revue hal-04644781 v1

Pharmacokinetic-pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses.

Elodie A Lallemand , Alain Bousquet-Mélou , Laura Chapuis , Jennifer Davis , Aude Ferran et al.
Frontiers in Microbiology, 2023, 14, pp.1282949. ⟨10.3389/fmicb.2023.1282949⟩
Article dans une revue hal-04352390 v1
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Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy

Emmanuelle Totain , Loic Lindner , Nicolas Martin , Yolande Misseri , Alexandra Iché et al.
Laboratory Animal Research, 2023, 39 (1), pp.14. ⟨10.1186/s42826-023-00166-3⟩
Article dans une revue hal-04750862 v1
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Residues of veterinary antibiotics in manures from pig and chicken farms in a context of antimicrobial use reduction by implementation of health and welfare plans

Marlene Lacroix , Felipe Ramon-Portugal , Alicia Huesca , Kyriacos Angastiniotis , Maro Simitopoulou et al.
Environmental Research, 2023, 238, pp.117242. ⟨10.1016/j.envres.2023.117242⟩
Article dans une revue hal-04235091 v1

Doxycycline serum protein binding in pigs reveals a relatively high free fraction

Felipe Ramon Portugal , Marlène Lacroix , Béatrice Roques , Véronique V. Gayrard-Troy , Pierre‐louis Toutain et al.
Journal of Veterinary Pharmacology and Therapeutics, 2023, ⟨10.1111/jvp.13111⟩
Article dans une revue hal-03989935 v1

Biased computation of probability of target attainment for antimicrobial drugs

Pierre‐louis Toutain , Peggy Gandia , Ludovic Pelligand , Aude Ferran , Peter Lees et al.
CPT: Pharmacometrics and Systems Pharmacology, 2023, 12 (5), pp.681-689. ⟨10.1002/psp4.12929⟩
Article dans une revue hal-04061755 v1

Combining sequential extraction and 3D fluorescence to investigate the behavior of antibiotic and polycyclic aromatic hydrocarbons during solar drying of sewage sludge

Amine Ezzariai , Amal An-Nori , Loubna El Fels , David Riboul , Georges Merlina et al.
Chemosphere, 2022, 298, pp.134293. ⟨10.1016/j.chemosphere.2022.134293⟩
Article dans une revue hal-03684696 v1
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The Selection of Antibiotic- and Bacteriophage-Resistant Pseudomonas aeruginosa Is Prevented by Their Combination

Aude A Ferran , Marlène Z Lacroix , Ophélie Gourbeyre , Alicia Huesca , Baptiste Gaborieau et al.
Microbiology Spectrum, 2022, 10 (5), pp.e0287422. ⟨10.1128/spectrum.02874-22⟩
Article dans une revue hal-03888726 v1
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Sequential removal of human antibiotics as a function of the dynamic of organic matter fractions and 3D fluorescence during sludge composting

Amine Ezzariai , Eric Pinelli , Loubna El Fels , Georges Merlina , David Riboul et al.
Journal of Environmental Chemical Engineering, 2022, 10 (3), pp.107956. ⟨10.1016/j.jece.2022.107956⟩
Article dans une revue hal-03766238 v1
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Repeated Exposure of Escherichia coli to High Ciprofloxacin Concentrations Selects gyrB Mutants That Show Fluoroquinolone-Specific Hyperpersistence

Aurore Perault , Catherine Turlan , Nathalie Eynard , Quentin Vallé , Alain Bousquet-Mélou et al.
Frontiers in Microbiology, 2022, 13, pp.908296. ⟨10.3389/fmicb.2022.908296⟩
Article dans une revue hal-03708916 v1

Selection of ESBL-producing Escherichia coli in the gut of calves experimentally fed with milk containing antibiotic residues

Véronique Dupouy , Jean-Yves Madec , Jessica Wucher , Nathalie Arpaillange , Véronique Métayer et al.
Veterinary Microbiology, 2021, 257, pp.109049. ⟨10.1016/j.vetmic.2021.109049⟩
Article dans une revue hal-03279732 v1
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Dynamic interactions between cephalexin and macrophages on different Staphylococcus aureus inoculum sizes: a tripartite in vitro model

Elodie A Lallemand , Claudine Zemirline , Pierre-Louis Toutain , Alain Bousquet‐mélou , Aude Ferran et al.
BMC Veterinary Research, 2021, 17 (1), ⟨10.1186/s12917-021-02746-8⟩
Article dans une revue hal-03198305 v1
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Prediction of Minocycline Activity in the Gut From a Pig Preclinical Model Using a Pharmacokinetic -Pharmacodynamic Approach

Quentin Vallé , Béatrice Roques , Alain Bousquet-Mélou , David Dahlhaus , Felipe Ramon-Portugal et al.
Frontiers in Microbiology, 2021, 12, ⟨10.3389/fmicb.2021.671376⟩
Article dans une revue hal-03319354 v1
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Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula

Carmen Espinosa-Gongora , Lisbeth Jessen , Oliver Dyar , Alain Bousquet‐mélou , Bruno González-Zorn et al.
Antibiotics, 2021, 10 (4), pp.364. ⟨10.3390/antibiotics10040364⟩
Article dans une revue hal-03190794 v1
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Destruction of Staphylococcus aureus biofilms by combining an antibiotic with subtilisin A or calcium gluconate

Jingjing Liu , Jean-Yves Madec , Alain Bousquet‐mélou , Marisa Haenni , Aude Ferran
Scientific Reports, 2021, 11 (1), pp.1-12. ⟨10.1038/s41598-021-85722-4⟩
Article dans une revue hal-03194522 v1
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Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs

Maria D Vegas Cómitre , Stefano Cortellini , Marc Cherlet , Mathias Devreese , Beatrice B Roques et al.
Frontiers in Veterinary Science, 2021, 8, ⟨10.3389/fvets.2021.770202⟩
Article dans une revue hal-03516328 v1

A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients

Alain Bousquet-Mélou , Anne Lespine , Jean-François Sutra , Isabelle Bargues , Pierre-Louis Toutain
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.666348⟩
Article dans une revue hal-03260114 v1

Rational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses

Taisuke Kuroda , Yohei Minamijima , Hidekazu Niwa , Norihisa Tamura , Hiroshi Mita et al.
Equine Veterinary Journal, 2021, ⟨10.1111/evj.13406⟩
Article dans une revue hal-03204606 v1

Antipoxvirus Activity Evaluation of Optimized Corroles Based on Development of Autofluorescent ANCHOR Myxoma Virus

Sandrine Kappler-Gratias , Léo Bucher , Sokunthea Top , Charlotte Quentin-Froignant , Nicolas Desbois et al.
ACS Infectious Diseases, 2021, 7 (8), pp.2370-2382. ⟨10.1021/acsinfecdis.1c00068⟩
Article dans une revue hal-03334449 v1
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Characterization and quantification of chlordecone elimination in ewes

Maïlie Saint-Hilaire , Aurore Fourcot , Alain Bousquet-Mélou , Guido Rychen , Jean-Pierre Thomé et al.
Environmental Toxicology and Pharmacology, 2021, 87, pp.103698. ⟨10.1016/j.etap.2021.103698⟩
Article dans une revue hal-03515239 v1
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Modeling chlordecone toxicokinetics data in growing pigs using a nonlinear mixed-effects approach

A. Fourcot , C. Feidt , Alain Bousquet‐mélou , A.A. Ferran , Jean-Luc Gourdine et al.
Chemosphere, 2020, 250, pp.126151. ⟨10.1016/j.chemosphere.2020.126151⟩
Article dans une revue hal-02935835 v1
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Authors' Reply to Krebs-Brown et al. Comment on: "Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?

Didier Concordet , Peggy Gandia , J L Montastruc , Alain Bousquet‐mélou , P Lees et al.
Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-019-00848-z⟩
Article dans une revue hal-02627432 v1
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Authors' Reply to Yu et al.: ""Levothyrox® New and Old Formulations: Are They Switchable for Millions of Patients?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-019-00852-3⟩
Article dans une revue hal-02619187 v1
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Early inoculation of microbial suspension in suckling piglets affects the transmission of maternal microbiota and the associated antibiotic resistance genes

Caroline Achard , Véronique Dupouy-Guiraute , Laurent Cauquil , Nathalie Arpaillange , Alain Bousquet‐mélou et al.
Microorganisms, 2020, 8 (10), pp.1576. ⟨10.3390/microorganisms8101576⟩
Article dans une revue hal-03106275 v1
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Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-019-00812-x⟩
Article dans une revue hal-02624662 v1
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The pharmacokinetic/pharmacodynamic paradigm for antimicrobial drugs in veterinary medicine: Recent advances and critical appraisal

Pierre‐louis Toutain , Ludovic Pelligand , Peter Lees , Alain Bousquet‐mélou , Aude Ferran et al.
Journal of Veterinary Pharmacology and Therapeutics, 2020, 44 (2), pp.172-200. ⟨10.1111/jvp.12917⟩
Article dans une revue (article de synthèse) hal-03133155 v1
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Antibiotic resistance: Tools for effective translational research

Marie-Cécile Ploy , Antoine Andremont , Bruno Valtier , Claire Le Jeunne , Catherine Dumartin et al.
Therapies, 2020, Giens Workshops 2019, 75 (1), pp.7-12. ⟨10.1016/j.therap.2019.12.003⟩
Article dans une revue hal-02516924 v1
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Authors' Reply to Nicolas: "Why Were More than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-019-00851-4⟩
Article dans une revue hal-02627433 v1
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Is Blood a Good Indicator for Detecting Antimicrobials in Meat? Evidence for the Development of In Vivo Surveillance Methods

María Jesús Serrano , Olga Mitjana , Cristina Bonastre , Alicia Laborda , María Victoria Falceto et al.
Antibiotics, 2020, 9 (4), pp.175. ⟨10.3390/antibiotics9040175⟩
Article dans une revue hal-03127743 v1
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Levers to Improve Antibiotic Treatment of Lambs via Drinking Water in Sheep Fattening Houses: The Example of the Sulfadimethoxine/Trimethoprim Combination

Aude Ferran , Marlène Z. Lacroix , Alain Bousquet‐mélou , Ivain Duhil , Béatrice Roques
Antibiotics, 2020, 9 (9), pp.561. ⟨10.3390/antibiotics9090561⟩
Article dans une revue hal-02955180 v1
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Antibiorésistance : outils pour une recherche translationnelle efficace

Marie-Cécile Ploy , Antoine Andremont , Bruno Valtier , Claire Le Jeunne , Catherine Dumartin et al.
Therapies, 2020, 75 (1), pp.1-6. ⟨10.1016/j.therap.2019.12.001⟩
Article dans une revue hal-02440782 v1

Determination of the pharmacokinetic‐pharmacodynamic cut‐off values of marbofloxacin in horses to support the establishment of a clinical breakpoint for antimicrobial susceptibility testing

Alain Bousquet‐mélou , Marc Schneider , Farid El Garch , Diane Broussou , Aude Ferran et al.
Equine Veterinary Journal, 2020, ⟨10.1111/evj.13385⟩
Article dans une revue hal-03113834 v1
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Authors' Reply to Lechat et al.: " New and Old Formulations: Are they Switchable for Millions of Patients?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2019, 58 (10), pp.1353-1354. ⟨10.1007/s40262-019-00815-8⟩
Article dans une revue hal-02619071 v1

Comparison of hydroalcoholic rubbing and conventional chlorhexidine scrubbing for aseptic skin preparation in dogs

Erik Asimus , Sophie Palierne , Margaux Blondel , Valentine Pollet , Aude Ferran et al.
Veterinary Surgery, 2019, 48 (8), pp.1466-1472. ⟨10.1111/vsu.13222⟩
Article dans une revue hal-02620124 v1

Pharmacokinetics of Ertapenem in Sheep (Ovis aries) with Experimentally Induced Urinary Tract Infection.

Joe S Smith , David J Borts , Clare C Slagel , Suzanne M Rajewski , Alain Bousquet‐mélou et al.
Comparative Medicine, 2019, 69 (5), pp.413-418. ⟨10.30802/AALAS-CM-18-000144⟩
Article dans une revue hal-02624660 v1
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Authors' Reply to Coste et al.:"Levothyrox New and Old Formulations: Are they Switchable for Millions of Patients?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2019, 58 (7), pp.967-968. ⟨10.1007/s40262-019-00780-2⟩
Article dans une revue hal-02623560 v1
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Comparison of in vitro static and dynamic assays to evaluate the efficacy of an antimicrobial drug combination against Staphylococcus aureus

Diane Broussou , Pierre-Louis Toutain , Frédérique Woehrlé , Farid El Garch , Alain Bousquet‐mélou et al.
PLoS ONE, 2019, 14 (1), pp.e0211214. ⟨10.1371/journal.pone.0211214⟩
Article dans une revue hal-01998871 v1
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Variability of the Ability of Complex Microbial Communities to Exclude Microbes Carrying Antibiotic Resistance Genes in Rabbits

Caroline Achard , Véronique Dupouy-Guiraute , Suzanne Siviglia , Nathalie Arpaillange , Laurent Cauquil et al.
Frontiers in Microbiology, 2019, 10, ⟨10.3389/fmicb.2019.01503⟩
Article dans une revue hal-02619189 v1
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Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, In press, 58 (7), pp.827-833. ⟨10.1007/s40262-019-00747-3⟩
Article dans une revue hal-02095017 v1
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Authors'Reply to Castello-Bridoux et al.:"Comment on Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2019, 58 (7), pp.973-975. ⟨10.1007/s40262-019-00786-w⟩
Article dans une revue hal-02627694 v1

Author's Reply to Trechot: "Comment on Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2019, 58 (7), pp.979-980. ⟨10.1007/s40262-019-00787-9⟩
Article dans une revue hal-02619069 v1
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Prevalence of Beta-Lactam and Quinolone/ Fluoroquinolone Resistance in Enterobacteriaceae From Dogs in France and Spain-Characterization of ESBL/pAmpC Isolates, Genes, and Conjugative Plasmids.

Véronique Dupouy-Guiraute , Mouni Abdelli , Gabriel Moyano , Nathalie Arpaillange , Delphine Bibbal et al.
Frontiers in Veterinary Science, 2019, 6, ⟨10.3389/fvets.2019.00279⟩
Article dans une revue hal-02619188 v1
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Authors' Reply to Nicolas:"New and Old Formulations: Are they Switchable for Millions of Patients?

Didier Concordet , Peggy Gandia , Jean-Louis Montastruc , Alain Bousquet‐mélou , Peter Lees et al.
Clinical Pharmacokinetics, 2019, 58 (7), pp.961-963. ⟨10.1007/s40262-019-00781-1⟩
Article dans une revue hal-02620199 v1
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Population Pharmacokinetic Study of Cefazolin Used Prophylactically in Canine Surgery for Susceptibility Testing Breakpoint Determination

Petra Cagnardi , Federica Di Cesare , Pierre-Louis Toutain , Alain Bousquet‐mélou , Giuliano Ravasio et al.
Frontiers in Pharmacology, 2018, 9, ⟨10.3389/fphar.2018.01137⟩
Article dans une revue hal-02621740 v1

KN Antimicrobials - The EU approach to antimicrobial susceptibility testing: science, stewardship and regulation (the EU VetCAST project)

Ludovic Pelligand , Pierre-Louis Toutain , Alain Bousquet‐mélou , P. Damborg , Aude A. Ferran et al.
Journal of Veterinary Pharmacology and Therapeutics, 2018, 41, pp.16
Article dans une revue hal-02619945 v1

Mixing of <em>Shiga</em> toxin-producing and enteropathogenic <em>Escherichia coli</em> in a wastewater treatment plant receiving city and slaughterhouse wastewater

Delphine Bibbal , Maryse Michèle Um , Alpha-Amadou Diallo , Monique M. Kérourédan , Véronique Dupouy-Guiraute et al.
International Journal of Hygiene and Environmental Health, 2018, 221 (2), pp.355-363. ⟨10.1016/j.ijheh.2017.12.009⟩
Article dans une revue hal-02621372 v1

A pressurized liquid extraction approach followed by standard addition method and UPLC-MS/MS for a fast multiclass determination of antibiotics in a complex matrix

Amine Ezzariai , David Riboul , Marlène Z. Lacroix , Maialen Barret , Loubna El Fels et al.
Chemosphere, 2018, 211, pp.893-902. ⟨10.1016/j.chemosphere.2018.08.021⟩
Article dans une revue hal-02623075 v1
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Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model.

Diane Broussou , Marlène Z. Lacroix , Pierre-Louis Toutain , Frédérique Woehrle , Farid El Garch et al.
Frontiers in Microbiology, 2018, 9, pp.572. ⟨10.3389/fmicb.2018.00572⟩
Article dans une revue hal-02620937 v1
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Prediction of human prenatal exposure to bisphenol A and bisphenol A glucuronide from an ovine semi-physiological toxicokinetic model

Glenn Gauderat , Nicole Picard-Hagen , Pierre-Louis Toutain , Rémi Servien , Catherine Viguié et al.
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-15646-5⟩
Article dans une revue hal-02628446 v1
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En route towards european clinical breakpoints for veterinary antimicrobial susceptibility testing: A position paper explaining the VetCAST approach

Pierre-Louis Toutain , Alain Bousquet‐mélou , Peter Damborg , Aude Ferran , Dik Mevius et al.
Frontiers in Microbiology, 2017, 8, 12 p. ⟨10.3389/fmicb.2017.02344⟩
Article dans une revue hal-02628320 v1

Capacity limits of asialoglycoprotein receptor-mediated liver targeting

Charlotte Bon , Thomas Höfer , Alain Bousquet‐mélou , Mark R. Davies , Ben-Fillippo Krippendorff
mAbs, 2017, 9 (8), pp.1360-1369. ⟨10.1080/19420862.2017.1373924⟩
Article dans une revue hal-02627537 v1
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Infection-stage adjusted dose of beta-lactams for parsimonious and efficient antibiotic treatments: A Pasteurella multocida experimental pneumonia in mice

Maleck V. Vasseur , Marlène Z. Lacroix , Pierre-Louis Toutain , Alain Bousquet‐mélou , Aude A. Ferran
PLoS ONE, 2017, 12 (8), 14 p. ⟨10.1371/journal.pone.0182863⟩
Article dans une revue hal-01604263 v1

Impact of low and high doses of marbofloxacin on the selection of resistant enterobacteriaceae in the commensal gut flora of young cattle: Discussion of data from 2 study populations

Guillaume Lhermie , Véronique Dupouy-Guiraute , Farid El Garch , Nadine Ravinet , Pierre-Louis Toutain et al.
Foodborne Pathogens and Disease, 2017, 14 (3), pp.152-159. ⟨10.1089/fpd.2016.2176⟩
Article dans une revue hal-01603817 v1
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Implementing Precision Antimicrobial Therapy for the Treatment of Bovine Respiratory Disease: Current Limitations and Perspectives.

Guillaume Lhermie , Pierre-Louis Toutain , Farid El Garch , Alain Bousquet‐mélou , Sébastien Assie
Frontiers in Veterinary Science, 2017, 4, pp.143. ⟨10.3389/fvets.2017.00143⟩
Article dans une revue hal-01608694 v1
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Veterinary Medicine Needs New Green Antimicrobial Drugs.

Pierre-Louis Toutain , Aude Ferran , Alain Bousquet‐mélou , Ludovic Pelligand , Peter Lees
Frontiers in Microbiology, 2016, 7, ⟨10.3389/fmicb.2016.01196⟩
Article dans une revue (article de synthèse) hal-02632279 v1

Dominant plasmids carrying extended spectrum β-lactamases blaCTX-M genes in genetically diverse <em>Escherichia coli</em> from slaughterhouse and urban wastewaters

Véronique Dupouy-Guiraute , Benoît Doublet , Nathalie Arpaillange , Karine Praud , Delphine Bibbal et al.
Environmental Microbiology Reports, 2016, 8 (5), pp.789-797. ⟨10.1111/1758-2229.12440⟩
Article dans une revue istex hal-02631274 v1

Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A.

Glenn Gauderat , Nicole Picard-Hagen , Pierre-Louis Toutain , Tanguy Corbel , Catherine Viguié et al.
Environment International, 2016, 86, pp.52-9. ⟨10.1016/j.envint.2015.10.006⟩
Article dans une revue hal-02641312 v1
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Impact of timing and dosage of a fluoroquinolone treatment on the microbiological, pathological, and clinical outcomes of calves challenged with Mannheimia haemolytica

Guillaume Lhermie , Aude Ferran , Sébastien Assié , Hervé Cassard , Farid El Garch et al.
Frontiers in Microbiology, 2016, 7, pp.1-13. ⟨10.3389/fmicb.2016.00237⟩
Article dans une revue hal-02633372 v1

Schéma thérapeutique: Impact sur la résistance

Alain Bousquet‐mélou
La Dépêche Technique, 2016, 142, pp.10-13
Article dans une revue hal-01602477 v1
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In vitro degradation of antimicrobials during use of broth microdilution method can increase the measured minimal inhibitory and minimal bactericidal concentrations

Elodie Anne Lallemand , Marlène Z. Lacroix , Pierre-Louis Toutain , Séverine Boullier , Aude Ferran et al.
Frontiers in Microbiology, 2016, 7, pp.1-6. ⟨10.3389/fmicb.2016.02051⟩
Article dans une revue hal-01602449 v1
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Comparison of the In vitro activity of five antimicrobial drugs against<em> Staphylococcus pseudintermedius</em> and <em>Staphylococcus aureus</em> Biofilms

Aude Ferran , Jing Jing Liu , Pierre-Louis Toutain , Alain Bousquet‐mélou
Frontiers in Microbiology, 2016, 7, pp.1187. ⟨10.3389/fmicb.2016.01187⟩
Article dans une revue hal-02631259 v1
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Comment on "In vitro effects of bisphenol A β-D-glucuronide (BPA-G) on adipogenesis in human and murine preadipocytes".

Véronique V. Gayrard-Troy , Glenn Gauderat , Marlène Z. Lacroix , Catherine Viguié , Alain Bousquet‐mélou et al.
Environmental Health Perspectives, 2015, 123 (12), pp.A289. ⟨10.1289/ehp.1510315⟩
Article dans une revue hal-02629934 v1
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Bacterial Species-Specific Activity of a Fluoroquinolone against Two Closely Related Pasteurellaceae with Similar MICs: Differential In Vitro Inoculum Effects and In Vivo Efficacies.

Guillaume Lhermie , Farid El Garch , Pierre-Louis Toutain , Aude Ferran , Alain Bousquet‐mélou
PLoS ONE, 2015, 10 (10), pp.e0141441. ⟨10.1371/journal.pone.0141441⟩
Article dans une revue hal-02633630 v1

Application of pharmacological principles to dosage design of antimicrobial drugs

Peter Lees , Ludovic Pelligand , Aude Ferran , Alain Bousquet‐mélou , Pierre-Louis Toutain
Pharmacology Matters, 2015, 8 (1)
Article dans une revue hal-02633242 v1

Veterinary medicine needs new and innovative green antimicrobial drugs

Pierre-Louis Toutain , Alain Bousquet‐mélou , Aude Ferran , Ludovic Pelligand , Peter Lees
Pharmacology Matters, 2015, 8 (1), pp.20-21
Article dans une revue hal-02630755 v1

Allometric scaling for predicting human clearance of bisphenol A

Séverine Collet , Nicole Picard-Hagen , Marlène Z. Lacroix , Sylvie Puel , Catherine Viguié et al.
Toxicology and Applied Pharmacology, 2015, 284 (3), pp.323-9. ⟨10.1016/j.taap.2015.02.024⟩
Article dans une revue hal-02637966 v1

Comparison of the reduction in the antibacterial potency of a fluoroquinolone conferred by a single mutation in the quinolone resistance-determining region or by the inoculum size effect.

Aude A Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
International Journal of Antimicrobial Agents, 2014, 44 (5), pp.472-4. ⟨10.1016/j.ijantimicag.2014.07.007⟩
Article dans une revue hal-02635372 v1

Problèmes et difficultés rencontrés lors de la planification et de l'analyse d'un essai de bioéquivalence.

Pierre-Louis Toutain , Peggy Gandia , Alain Bousquet‐mélou
La Lettre du Pharmacologue, 2014, 28 (2), pp.37-50
Article dans une revue hal-02630493 v1

Prévention de la résistance aux antibiotiques: le bon usage dans les élevages et en médecine vétérinaire

Alain Bousquet‐mélou
Hygiènes, 2014, XXII (4)
Article dans une revue hal-02629962 v1

Rebuttal to the reaction of the EGGVP to the review article 'The consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: the need for new antibiotics'.

Pierre Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2014, 37 (6), pp.618-23. ⟨10.1111/jvp.12166⟩
Article dans une revue istex hal-02630946 v1

Low or high doses of cefquinome targeting low or high bacterial inocula cure Klebsiella pneumoniae lung infections but differentially impact the levels of antibiotic resistance in fecal flora.

Maleck V. Vasseur , Michel Laurentie , Jean-Guy Rolland , Agnès Perrin-Guyomard , Jérôme Henri et al.
Antimicrobial Agents and Chemotherapy, 2014, 58 (3), pp.1744-8. ⟨10.1128/AAC.02135-13⟩
Article dans une revue hal-00978511 v1

Use of Monte Carlo simulation to determine pharmacodynamic cutoffs of amoxicillin to establish a breakpoint for antimicrobial susceptibility testing in pigs

Julien Rey , Céline M. Laffont , Siska Croubels , Patrick de Backer , Claudine Zemirline et al.
American Journal of Veterinary Research, 2014, 75 (2), pp.124-31. ⟨10.2460/ajvr.75.2.124⟩
Article dans une revue hal-02641639 v1
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Pharmacologie des anti-inflammatoires disponibles pour les animaux de rente

Aude Ferran , Alain Bousquet‐mélou
Bulletin des G.T.V., 2014, 76, pp.35-40
Article dans une revue (article de synthèse) hal-02630208 v1

Pharmacokinetic/pharmacodynamic assessment of the effects of parenteral administration of a fluoroquinolone on the intestinal microbiota: Comparison of bactericidal activity at the gut versus the systemic level in a pig model.

Aude A Ferran , Delphine Bibbal , Terence Pellet , Michel Laurentie , Mireille Gicquel-Bruneau et al.
International Journal of Antimicrobial Agents, 2013, 42 (5), pp.429-35. ⟨10.1016/j.ijantimicag.2013.07.008⟩
Article dans une revue istex hal-00875291 v1

The consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: the need for new antibiotics

Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2013, 36 (5), pp.420-424. ⟨10.1111/jvp.12061⟩
Article dans une revue istex hal-02645451 v1

Persistence and prevalence of pathogenic and extended-spectrum beta-lactamase-producing Escherichia coli in municipal wastewater treatment plant receiving slaughterhouse wastewater

Alpha-Amadou Diallo , Hubert Brugère , Monique M. Kérourédan , Véronique Dupouy-Guiraute , Pierre-Louis Toutain et al.
Water Research, 2013, 47 (13), pp.4719 - 4729. ⟨10.1016/j.watres.2013.04.047⟩
Article dans une revue istex hal-02645474 v1
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Interpreting bisphenol a absorption in the canine oral cavity: gayrard et Al. Respond.

Véronique V. Gayrard-Troy , Marlène Z. Lacroix , Séverine Collet , Catherine Viguié , Alain Bousquet‐mélou et al.
Environmental Health Perspectives, 2013, 121 (11-12), pp.A323-4. ⟨10.1289/ehp.1307424R⟩
Article dans une revue hal-02644875 v1
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High bioavailability of bisphenol A from sublingual exposure.

Véronique V. Gayrard-Troy , Marlène Z. Lacroix , Séverine Collet , Catherine Viguié , Alain Bousquet‐mélou et al.
Environmental Health Perspectives, 2013, 121 (8), pp.951-6. ⟨10.1289/ehp.1206339⟩
Article dans une revue hal-02645480 v1

Comment traiter une inflammation chez les bovins effets recherchés et effets indésirables des molécules anti-inflammatoires

Aude Ferran , Alain Bousquet‐mélou , Pierre-Louis Toutain
Le Nouveau Praticien Vétérinaire. Elevages et Santé, 2012, 5 (22), pp.58-64
Article dans une revue hal-02641849 v1
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Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test

Ahmed Khadra , Eric Pinelli , Marlène Z. Lacroix , Alain Bousquet‐mélou , H Hamdi et al.
Ecotoxicology and Environmental Safety, 2012, 76, pp.187-192. ⟨10.1016/j.ecoenv.2011.10.012⟩
Article dans une revue hal-01191262 v1
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Le concept « One Health » en antibiorésistance et les flux de gènes

Benoît Doublet , Alain Bousquet‐mélou , J.Y. Madec
Innovations Agronomiques, 2012, 24, pp.79-90. ⟨10.17180/81bk-4946⟩
Article dans une revue hal-02642975 v1
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Nouvelles stratégies en antibiothérapie

Alain Bousquet‐mélou
Pratique Veterinaire, 2012, 93, pp.3
Article dans une revue hal-02646746 v1
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Should licking behavior be considered in the bioavailability evaluation of transdermal products?

Pierre-Louis Toutain , Sanja Modric , Alain Bousquet‐mélou , Juan M Sallovitz , Carlos Lanusse
Journal of Veterinary Pharmacology and Therapeutics, 2012, 35, pp.39-43. ⟨10.1111/j.1365-2885.2012.01380.x⟩
Article dans une revue hal-01136992 v1
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Léchage entre congénères et antiparasitaires en [i]pour-on[/i].

Alain Bousquet‐mélou
Le Point vétérinaire, 2012, 43, pp.124-126
Article dans une revue hal-01191268 v1
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Susceptibility of Two European strains of Stomoxys calcitrans (L.) to Cypermethrin, Deltamethrin, Fenvalerate, lambda-cyhalothrin, Permethrin and Phoxim

Ali Salem , Emilie Bouhsira , Emmanuel Liénard , Alain Bousquet‐mélou , Philippe Jacquiet et al.
The Journal of Applied Research in Veterinary Medicine, 2012, 10 (3), pp.249 - 257
Article dans une revue hal-02645910 v1
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Impact du schéma posologique sur la résistance.

Alain Bousquet‐mélou , Aude Ferran , Pierre-Louis Toutain
Bulletin des G.T.V., 2012, 64, pp.29-36
Article dans une revue hal-01136975 v1
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Licking behaviour induces partial anthelmintic efficacy of ivermectin pour-on formulation in untreated cattle.

Alain Bousquet‐mélou , Philippe Jacquiet , Hervé Hoste , Julien Clément , Jean-Paul Bergeaud et al.
Int J Parasitol, 2011, 41 (5), epub ahead of print. ⟨10.1016/j.ijpara.2010.12.007⟩
Article dans une revue hal-00556815 v1
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Utilisation des antibiotiques en élevage et enjeux de santé publique

Pascal Sanders , Alain Bousquet‐mélou , Claire Chauvin , Pierre-Louis Toutain
INRA Productions Animales, 2011, 24 (2), pp.199-204
Article dans une revue hal-01191161 v1

Laparoscopic-assisted colopexy and sterilization in male dogs: short-term results and physiologic consequences

Didier H. Mathon , Sophie Palierne , Patricia Meynaud-Collard , Catherine Layssol-Lamour , Alice Dulaurent-Ferrieres et al.
Veterinary Surgery, 2011, 40 (4), pp.500-508. ⟨10.1111/j.1532-950X.2011.00835.x⟩
Article dans une revue istex hal-02644128 v1
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Antibiothérapie : les questions qu'il faut se poser avant toute prescription

Aude Ferran , Alain Bousquet‐mélou
Pratique Veterinaire, 2011, 46, pp.86-88
Article dans une revue hal-02646601 v1
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Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection.

Aude A Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
Vet Microbiol, 2011, 148 (2-4), pp.292-7. ⟨10.1016/j.vetmic.2010.09.005⟩
Article dans une revue hal-00523818 v1

Species differences in pharmacokinetics and pharmacodynamics.

Pierre-Louis Toutain , Aude Ferran , Alain Bousquet‐mélou
Handb Exp Pharmacol, 2010, 199, pp.19-48. ⟨10.1007/978-3-642-10324-7_2⟩
Article dans une revue hal-00517529 v1
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Emergence of resistant Klebsiella pneumoniae in the intestinal tract during successful treatment of Klebsiella pneumoniae lung infection in rats.

Anne-Sylvie Kesteman , Agnès Perrin-Guyomard , Michel Laurentie , Pascal Sanders , Pierre-Louis Toutain et al.
Antimicrobial Agents and Chemotherapy, 2010, 54 (7), pp.2960-4. ⟨10.1128/AAC.01612-09⟩
Article dans une revue hal-00517528 v1
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Pharmacokinetic/pharmacodynamic analysis of the influence of inoculum size on the selection of resistance in Escherichia coli by a quinolone in a mouse thigh bacterial infection model.

Aude A Ferran , Anne-Sylvie Kesteman , Pierre-Louis Toutain , Alain Bousquet‐mélou
Antimicrobial Agents and Chemotherapy, 2009, 53 (8), pp.3384-90. ⟨10.1128/AAC.01347-08⟩
Article dans une revue hal-00517532 v1

Impact of marbofloxacin dosing regimen on intestinal flora in a dixenic rat model with Klebsiella pneumoniae lung infection

Anne-Sylvie Kesteman , Aa Ferran , A Perrin-Guyomard , Michel Laurentie , Pascal Sanders et al.
Journal of Veterinary Pharmacology and Therapeutics, 2009, 32 (s1), pp.150-151
Article dans une revue hal-02656744 v1

Relatedness of Ampicillin-resistant Escherichia coli strains isolated from pigs during ampicillin treatment

Delphine Bibbal , V Dupouy , Nathalie Arpaillange , Mf Prere , Pierre-Louis Toutain et al.
Journal of Veterinary Pharmacology and Therapeutics, 2009, 32, pp.138-139
Article dans une revue hal-02656491 v1

Influence of inoculum size and dosing regimen on the selection of marbofloxacin resistant mutants in experimental rat Klebsiella pneumoniae lung infection

Anne-Sylvie Kesteman , Aa Ferran , A Perrin-Guyomard , Michel Laurentie , Pascal Sanders et al.
Journal of Veterinary Pharmacology and Therapeutics, 2009, 32 (s1), pp.63-63
Article dans une revue hal-02654001 v1
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Relatedness of Escherichia coli strains with different susceptibility phenotypes isolated from swine feces during ampicillin treatment.

Delphine Bibbal , Véronique Dupouy-Guiraute , Marie-Françoise Prère , Pierre-Louis Toutain , Alain Bousquet‐mélou
Applied and Environmental Microbiology, 2009, 75 (10), pp.2999-3006. ⟨10.1128/AEM.02143-08⟩
Article dans une revue hal-00517533 v1
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Influence of inoculum size and marbofloxacin plasma exposure on the amplification of resistant subpopulations of Klebsiella pneumoniae in a rat lung infection model.

Anne-Sylvie Kesteman , Aude A Ferran , Agnès Perrin-Guyomard , Michel Laurentie , Pascal Sanders et al.
Antimicrobial Agents and Chemotherapy, 2009, 53 (11), pp.4740-8. ⟨10.1128/AAC.00608-09⟩
Article dans une revue hal-00517531 v1

Influence of obesity on the pharmacokinetics of anthelmintic macrocyclic lactones in dogs

I Bargues , Anne Lespine , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2009, 32 (s1), pp.161-162
Article dans une revue hal-02654350 v1

New antibiotics in orphan food-producing animals: what is the responsibility of a journal regarding good veterinary practice?

Pierre-Louis Toutain , Alain Bousquet‐mélou
Veterinary Journal, 2009, 179 (2), pp.155-7. ⟨10.1016/j.tvjl.2008.03.022⟩
Article dans une revue istex hal-00517536 v1

A PK/PD analysis of the selection of marbofloxacin resistance in Escherichia coli in a mouse-thigh infection model

Aa Ferran , Anne-Sylvie Kesteman , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2009, 32 (s1), pp.69-70
Article dans une revue hal-02653949 v1

Les apports et les limites de la clinique et des essais cliniques dans l'évaluation des antibiotiques

Pierre-Louis Toutain , Alain Bousquet‐mélou
Bulletin des G.T.V., 2008, 43, pp.57-62
Article dans une revue hal-02653542 v1

L'antibiothérapie dans les entérites infectieuses néonatales du veau

Pierre-Louis Toutain , Alain Bousquet‐mélou
Le Nouveau Praticien Vétérinaire. Elevages et Santé, 2008, pp.27-30
Article dans une revue hal-02653320 v1

Induction of the carrier state in pigeons infected with Salmonella enterica subspecies enterica serovar typhimurium PT99 by treatment with florfenicol: a matter of pharmacokinetics.

Frank Pasmans , Kris Baert , An Martel , Alain Bousquet‐mélou , Ruben Lanckriet et al.
Antimicrobial Agents and Chemotherapy, 2008, 52 (3), pp.954-61. ⟨10.1128/AAC.00575-07⟩
Article dans une revue hal-00517567 v1

Les bonnes pratiques de l'antibiothérapie chez le cheval

Aude Ferran , Alain Bousquet‐mélou , Pierre-Louis Toutain
Le Nouveau Praticien Vétérinaire. Equine, 2008, pp.117-121
Article dans une revue hal-02654400 v1

Oral absorption of ampicillin: role of paracellular route vs. PepT1 transporter.

Guylène Lafforgue , Cécile Arellano , Christelle Vachoux , John Woodley , Claude Philibert et al.
Fundamental & Clinical Pharmacology, 2008, 22 (2), pp.189-201. ⟨10.1111/j.1472-8206.2008.00572.x⟩
Article dans une revue istex hal-00517537 v1

Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration.

V. Vandenbroucke , Alain Bousquet‐mélou , Patrick de Backer , Siska Croubels
Journal of Veterinary Pharmacology and Therapeutics, 2008, 31 (5), pp.437-45. ⟨10.1111/j.1365-2885.2008.00979.x⟩
Article dans une revue istex hal-00517535 v1
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Impact of three ampicillin dosage regimens on selection of ampicillin resistance in Enterobacteriaceae and excretion of blaTEM genes in swine feces.

Delphine Bibbal , Véronique Dupouy-Guiraute , Jean-Pierre Ferré , Pierre-Louis Toutain , Olivier Fayet et al.
Applied and Environmental Microbiology, 2007, 73 (15), pp.4785-90. ⟨10.1128/AEM.00252-07⟩
Article dans une revue hal-00517560 v1

AUC/MIC: a PK/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor?

Pierre-Louis Toutain , Alain Bousquet‐mélou , Marilyn Martinez
Journal of Antimicrobial Chemotherapy, 2007, 60 (6), pp.1185-8. ⟨10.1093/jac/dkm360⟩
Article dans une revue istex hal-00517556 v1

Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration.

Elodie Lallemand , Anne Lespine , Michel Alvinerie , Alain Bousquet‐mélou , Pierre-Louis Toutain
Journal of Veterinary Pharmacology and Therapeutics, 2007, 30 (5), pp.375-80. ⟨10.1111/j.1365-2885.2007.00878.x⟩
Article dans une revue istex hal-00517557 v1
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Influence of inoculum size on the selection of resistant mutants of Escherichia coli in relation to mutant prevention concentrations of marbofloxacin.

Aude Ferran , Véronique Dupouy-Guiraute , Pierre-Louis Toutain , Alain Bousquet‐mélou
Antimicrobial Agents and Chemotherapy, 2007, 51 (11), pp.4163-6. ⟨10.1128/AAC.00156-07⟩
Article dans une revue hal-00517559 v1

Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

Anne Lespine , Guillaume Chanoit , Alain Bousquet‐mélou , Elodie Lallemand , Firas Mohamad Bassissi et al.
European Journal of Pharmaceutical Sciences, 2006, 27 (1), pp.37-43. ⟨10.1016/j.ejps.2005.08.003⟩
Article dans une revue istex hal-00517563 v1
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The adrenocorticotropin stimulation test: contribution of a physiologically based model developed in horse for its interpretation in different pathophysiological situations encountered in man.

Alain Bousquet‐mélou , Enrique Formentini , Nicole Picard-Hagen , Laure Delage , Valérie Laroute et al.
Endocrinology, 2006, 147 (9), pp.4281-91. ⟨10.1210/en.2005-1161⟩
Article dans une revue hal-00517562 v1

Enrofloxacin and marbofloxacin in horses: comparison of pharmacokinetic parameters, use of urinary and metabolite data to estimate first-pass effect and absorbed fraction.

Mathieu Peyrou , Alain Bousquet‐mélou , Valérie Laroute , André Vrins , Michèle Y. Doucet
Journal of Veterinary Pharmacology and Therapeutics, 2006, 29 (5), pp.337-44. ⟨10.1111/j.1365-2885.2006.00752.x⟩
Article dans une revue istex hal-00517561 v1

Particularité des voies orales et topiques chez les ruminants : conséquences pour les antiparasitaires

Pierre-Louis Toutain , Alain Bousquet‐mélou
Bulletin des G.T.V., 2005, Hors-série, pp.43-47
Article dans une revue hal-02670330 v1

Pharmacokinetics and pharmacodynamics of a therapeutic dose of unfractionated heparin (200 U/kg) administered subcutaneously or intravenously to healthy dogs.

Armelle Diquélou , C. Barbaste , A. M. Gabaig , Cathy Trumel , Nathalie Abella-Bourges et al.
Veterinary Clinical Pathology, 2005, 34 (3), pp.237-42
Article dans une revue hal-00517564 v1

Pharmacokinetics and pharmacodynamics of a therapeutic dose of unfractionated heparin (200 U/kg) administered subcutaneously or intravenously to healthy dogs

Armelle Diquélou , Cécile Barbaste , Am Gabaig , Catherine Trumel , Nathalie Abella-Bourges et al.
Veterinary Clinical Pathology, 2005, 34 (3), pp.237-242. ⟨10.1111/j.1939-165x.2005.tb00047.x⟩
Article dans une revue hal-02670873 v1

Comment déterminer et optimiser un schéma posologique pour un antibiotique

Pierre-Louis Toutain , Alain Bousquet‐mélou
Bulletin des G.T.V., 2005, Hors-série, pp.57-62
Article dans une revue hal-02669487 v1

Plasma clearance.

Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2004, 27 (6), pp.415-25. ⟨10.1111/j.1365-2885.2004.00605.x⟩
Article dans une revue istex hal-00517571 v1

Population pharmacokinetics of marbofloxacin in horses: preliminary analysis.

Mathieu Peyrou , Michèle Y. Doucet , André Vrins , Didier Concordet , Marc Schneider et al.
Journal of Veterinary Pharmacology and Therapeutics, 2004, 27 (5), pp.283-8. ⟨10.1111/j.1365-2885.2004.00591.x⟩
Article dans une revue istex hal-00517574 v1

Plasma terminal half-life.

Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2004, 27 (6), pp.427-39. ⟨10.1111/j.1365-2885.2004.00600.x⟩
Article dans une revue istex hal-00517570 v1

Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin.

Alain Bousquet‐mélou , Sonia Mercadier , Michel Alvinerie , Pierre-Louis Toutain
International Journal for Parasitology, 2004, 34 (11), pp.1299-307. ⟨10.1016/j.ijpara.2004.08.005⟩
Article dans une revue istex hal-00517575 v1

Volumes of distribution.

Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2004, 27 (6), pp.441-53. ⟨10.1111/j.1365-2885.2004.00602.x⟩
Article dans une revue istex hal-00517569 v1

Bioavailability and its assessment.

Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2004, 27 (6), pp.455-66. ⟨10.1111/j.1365-2885.2004.00604.x⟩
Article dans une revue istex hal-00517568 v1

A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle.

Céline M. Laffont , Alain Bousquet‐mélou , David Bralet , Michel Alvinerie , Johanna Fink-Gremmels et al.
Veterinary Research, 2003, 34 (4), pp.445-60. ⟨10.1051/vetres:2003014⟩
Article dans une revue hal-00517578 v1
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A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle

Céline M. Laffont , Alain Bousquet‐mélou , David Bralet , Michel Alvinerie , Johanna Fink-Gremmels et al.
Veterinary Research, 2003, 34 (4), pp.445-460. ⟨10.1051/vetres:2003014⟩
Article dans une revue hal-00902759 v1

Antibiothérapie au tarissement Les spécialités disponibles curatives et/ou préventives

Alain Bousquet‐mélou
Le Point vétérinaire, 2003, Supplément, pp.19-23
Article dans une revue hal-02670292 v1

The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics.

Pierre-Louis Toutain , Jérome R. E. del Castillo , Alain Bousquet‐mélou
Research in Veterinary Science, 2002, 73 (2), pp.105-14. ⟨10.1016/S0034-5288(02)00039-5⟩
Article dans une revue istex hal-00517583 v1

Intestinal secretion is a major route for parent ivermectin elimination in the rat.

Céline M. Laffont , Pierre-Louis Toutain , Michel Alvinerie , Alain Bousquet‐mélou
Drug Metabolism and Disposition, 2002, 30 (6), pp.626-30
Article dans une revue hal-00517587 v1

Modelling the loss of metabolic capacities of cultured hepatocytes: application to measurement of Michaelis-Menten kinetic parameters in in vitro systems.

Alain Bousquet‐mélou , Céline M. Laffont , Valérie Laroute , Pierre-Louis Toutain
Xenobiotica, 2002, 32 (10), pp.895-906. ⟨10.1080/00498250210163261⟩
Article dans une revue hal-00517576 v1

Effects of altered plasma alpha1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis.

Alain Bousquet‐mélou , Pierre-Louis Toutain
Journal of Veterinary Pharmacology and Therapeutics, 2002, 25 (3), pp.239
Article dans une revue hal-00517586 v1

Free drug fraction vs free drug concentration: a matter of frequent confusion.

Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2002, 25 (6), pp.460-3. ⟨10.1046/j.1365-2885.2002.00442.x⟩
Article dans une revue istex hal-00517582 v1
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Letter to the Editor

Alain Bousquet‐mélou , Pierre-Louis Toutain
Journal of Veterinary Pharmacology and Therapeutics, 2002, 25 (3), pp.239-239
Article dans une revue hal-02669513 v1

Pharmacokinetics of marbofloxacin in horses.

Alain Bousquet‐mélou , Sophie Bernard , Marc Schneider , Pierre-Louis Toutain
Equine Veterinary Journal, 2002, 34 (4), pp.366-72. ⟨10.2746/042516402776249191⟩
Article dans une revue istex hal-00517584 v1

Licking behaviour and environmental contamination arising from pour-on ivermectin for cattle.

Céline M. Laffont , Michel Alvinerie , Alain Bousquet‐mélou , Pierre-Louis Toutain
International Journal for Parasitology, 2001, 31 (14), pp.1687-92
Article dans une revue hal-00517588 v1
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A nonlabeled method to evaluate cortisol production rate by modeling plasma CBG-free cortisol disposition.

Nicole Picard-Hagen , Véronique V. Gayrard-Troy , Michel Alvinerie , Hélène Smeyers , Raphael Ricou et al.
AJP - Endocrinology and Metabolism, 2001, 281 (5), pp.E946-56. ⟨10.1152/ajpendo.2001.281.5.E946⟩
Article dans une revue hal-00517589 v1

Relevance of kinetic concepts to interpret a plasma concentration in clinical biochemistry (clearance, production rate, binding, half-life)

P.L. Toutain , H.P. Lefebvre , Alain Bousquet‐mélou
Revue de Médecine Vétérinaire, 2000, 151 (7), pp.643-648
Article dans une revue hal-02684014 v1

Lipolytic effects of beta 1-, beta 2-, and beta 3-adrenergic agonists in white adipose tissue of mammals.

Christian Carpéné , Alain Bousquet‐mélou , Jean Galitzky , Max Lafontan , Non Renseigné
Annals of the New York Academy of Sciences, 1998, 839, pp.186-9
Article dans une revue hal-00517591 v1

Adrenergic regulation of adipocyte metabolism.

M. Lafontan , P. Barbe , J. Galitzky , G. Tavernier , D. Langin et al.
Human Reproduction, 1997, 12 Suppl 1, pp.6-20
Article dans une revue hal-00517592 v1

Evidence for numerous brown adipocytes lacking functional beta 3-adrenoceptors in fat pads from nonhuman primates.

N. Viguerie-Bascands , Alain Bousquet‐mélou , J. Galitzky , D. Larrouy , D. Ricquier et al.
Journal of Clinical Endocrinology and Metabolism, 1996, 81 (1), pp.368-75
Article dans une revue hal-00517758 v1

Control of lipolysis in intra-abdominal fat cells of nonhuman primates: comparison with humans.

Alain Bousquet‐mélou , Jean Galitzky , M. Lafontan , M. Berlan
Journal of Lipid Research, 1995, 36 (3), pp.451-61
Article dans une revue hal-00517763 v1

[Lipid mobilization, physiopathological and pharmacological aspects]

M. Berlan , P. Barbe , V. Stich , Jean Galitzky , Alain Bousquet‐mélou et al.
Annales d'Endocrinologie = Annals of Endocrinology, 1995, 56 (2), pp.97-100
Article dans une revue hal-00517765 v1

Adrenergic receptors and fat cells: differential recruitment by physiological amines and homologous regulation.

M. Lafontan , Alain Bousquet‐mélou , J. Galitzky , P. Barbe , C. Carpéné et al.
Obesity Research, 1995, 3 Suppl 4 (6), pp.507S-514S
Article dans une revue hal-00517759 v1

Differential activation of beta 1-, beta 2- and beta 3-adrenoceptors by catecholamines in white and brown adipocytes.

Jean Galitzky , C. Carpéné , Alain Bousquet‐mélou , M. Berlan , M. Lafontan
Fundamental & Clinical Pharmacology, 1995, 9 (4), pp.324-31
Article dans une revue hal-00517764 v1

Desensitization of beta-adrenergic responses in adipocytes involves receptor subtypes and cAMP phosphodiesterase.

Alain Bousquet‐mélou , Jean Galitzky , C. M. Moreno , M. Berlan , M. Lafontan
European Journal of Pharmacology, 1995, 289 (2), pp.235-47
Article dans une revue hal-00517760 v1

beta-Adrenergic control of lipolysis in primate white fat cells: a comparative study with nonprimate mammals.

Alain Bousquet‐mélou , Jean Galitzky , C. Carpéné , M. Lafontan , M. Berlan
American Journal of Physiology, 1994, 267 (1 Pt 2), pp.R115-23
Article dans une revue hal-00517768 v1

Beta-3 adrenoceptor-mediated increase in cutaneous blood flow in the dog.

M. Berlan , J. Galitzky , Alain Bousquet‐mélou , M. Lafontan , J. L. Montastruc
Journal of Pharmacology and Experimental Therapeutics, 1994, 268 (3), pp.1444-51
Article dans une revue hal-00517771 v1

The positive chronotropic effect induced by BRL 37344 and CGP 12177, two beta-3 adrenergic agonists, does not involve cardiac beta adrenoceptors but baroreflex mechanisms.

G. Tavernier , J. Galitzky , Alain Bousquet‐mélou , J. L. Montastruc , M. Berlan
Journal of Pharmacology and Experimental Therapeutics, 1992, 263 (3), pp.1083-90
Article dans une revue hal-00517774 v1

GRF treatment of late pregnant ewes alters maternal and fetal somatotropic axis activity.

M. M. Blanchard , C. G. Goodyer , J. Charrier , G. Kann , R. Garcia-Villar et al.
American Journal of Physiology, 1991, 260 (4 Pt 1), pp.E575-80
Article dans une revue hal-00517775 v1

Mitigation of antibioresistance dissemination through the comprehensive optimization of sludge treatment

Amine Ezzariai , Lucie Sauvadet , Gnaneswaran Jenita , Nathalie Arpaillange , Maialen Barret et al.
5th IWA Specialized International Conference ‘Ecotechnologies for Wastewater Treatment (ecoSTP), university of Milano, Jun 2021, Milan, Italy
Communication dans un congrès hal-04166692 v1

The EUCAST/VETCAST approach to breakpoint and determination

Pierre-Louis Toutain , Ludovic Pelligand , Alain Bousquet‐mélou , Peter Damborg , Aude Ferran et al.
9.th International Conference on Antimicrobial Agents in Veterinary Medicine, Antimicrobial Agents in Veterinary Medicine (AAVM). Rome, ITA., Oct 2018, Rome, Italy
Communication dans un congrès hal-02735427 v1

Antibiotic treatments via drinking water in sheep fattening houses: how to ensure an adequate exposure of the treated population?

Béatrice Roques , Marlène Z. Lacroix , Laura Fouzari , Aude Ferran , Didier Concordet et al.
14. International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jun 2018, Wroclaw, Poland
Communication dans un congrès hal-02734792 v1

Pharmacodynamics of ertapenem with and without concurrent use of an immunostimulant using an induced cystitis model in sheep

J. Smith , C. Slagel , D. Borts , Aude Ferran , Alain Bousquet‐mélou et al.
14. International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jun 2018, Wroclaw, Poland
Communication dans un congrès hal-02733821 v1

Comment assurer l’exposition adéquate d’une population d’agneaux lors de l’administration d’antibiotiques via l’eau de boisson en atelier d’engraissement ovin

Béatrice Roques , Marlène Z. Lacroix , Laura Fouzari , Aude Ferran , Didier Concordet et al.
24 E Journées " Rencontres Recherches Ruminants (3R), 2018, Paris, France
Communication dans un congrès hal-03275416 v1

Assessment of amikacin and vancomycin combination efficacy on two Staphylococcus aureus strains: a comparison between static and dynamic in vitro methods

Diane Broussou , F. El Garch , F. Whoerle , P. L. Toutain , Alain Bousquet‐mélou et al.
14. International Congress of the European Association for Veterinary Pharmacology and Toxicology, 2018, Wroclaw, Poland
Communication dans un congrès hal-02736593 v1

KN Precision medicine for the prudent use of veterinary antimicrobials in food producing animals

Alain Bousquet‐mélou
14. International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jun 2018, Wroclaw, Poland. pp.1
Communication dans un congrès hal-02734350 v1

Exposure evaluation of Fipronil: from pets to fleas

Marlène Z. Lacroix , E. Bouhsira , E. Liénard , Catherine Viguié , M. Franc et al.
14. International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jun 2018, Wroclaw, Poland. pp.1
Communication dans un congrès hal-02738214 v1

Development of an in vitro model for the multiparametric quantification of interactions between Staphylococcus aureus, murine macrophages and a cephalosporin antibiotic

Elodie Lallemand , Aude Ferran , C. Zemirline , Pierre-Louis Toutain , S. Boullier et al.
Abstracts of the 50th Annual Scientific Meeting of the European Society for Clinical Investigation, Apr 2016, Paris, France. pp.2
Communication dans un congrès hal-02741238 v1
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Role of the metacommunity in the colonization of rabbit's intestinal tract to fight against antibiotic-resistant bacteria

Caroline Achard , Beatrice Gabinaud , Sylvie Combes , Véronique Dupouy-Guiraute , Yuliaxis Ramayo Caldas et al.
16. International Symposium on Microbial Ecology - ISME16, Aug 2016, Montréal, Canada
Communication dans un congrès hal-02799866 v1

Veterinary medicine needs new and innovative green antibiotics

Pierre-Louis Toutain , Aude Ferran , Alain Bousquet‐mélou , Ludovic Pelligand , Peter Lees
Conference on Residues of Veterinary Drugs in Food, EuroResidue VIII., May 2016, Egmond aan Zee, Netherlands
Communication dans un congrès hal-01606643 v1

The consequences of generic marketing on antibiotic consumption and the spread of antimicrobial resistance: the need for new antibiotics

Alain Bousquet‐mélou , Pierre-Louis Toutain
13th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT), European Association for Veterinary Pharmacology and Toxicology (EAVPT). FRA., Jul 2015, Nantes, France
Communication dans un congrès hal-02743077 v1
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Etat des lieux de l'antibiorésistance en élevage cunicole français et application du concept d'exclusion compétitive pour limiter la transmission d'un microbiote maternal antibiorésistant

Caroline Achard , Véronique Dupouy-Guiraute , Susanna Siviglia , Nathalie Arpaillange , Beatrice Gabinaud et al.
16. Journées de la Recherche Cunicole, Nov 2015, Le Mans, France. 264 p
Communication dans un congrès hal-02744277 v1

Impact of a decreased antimicrobial therapy at early stage of spontaneous bovine pneumonia cases on antimicrobial consumption and therapeutic efficacy

Guillaume Lhermie , Alain Bousquet‐mélou , Farid El Garch , Henri Seegers , Sébastien Assie
14. International Symposium on Veterinary Epidemiology and Economics (ISVEE), Nov 2015, Mérida, Yucatan, Mexico. 670 p
Communication dans un congrès hal-02742841 v1

Evaluation of the influence of treatment time and antibiotic dosage regimen on bacterial burden and clinical outcomes in experimentally infected calves with Mannheimia haemolytica

Guillaume Lhermie , Aude Ferran , Farid El Garch , Marc Schneider , Frédérique Woerhlé et al.
13th. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT), European Association for Veterinary Pharmacology and Toxicology (EAVPT). FRA., Jul 2015, Nantes, France. pp.176
Communication dans un congrès hal-02742822 v1

Resistome of pig and rabbit gut microbiota using high-troughput sequencing and qPCR approaches

Caroline Achard , Véronique Dupouy-Guiraute , Yuliaxis Ramayo Caldas , Beatrice Gabinaud , Catherine Denis et al.
6. Symposium on Antimicrobial Résistance in Animals and the Environment (ARAE), Jun 2015, Tours, France. 109p
Communication dans un congrès hal-01536555 v1

Bisphenol A-glucuronide hydrolysis in the ovine fetal compartment prolongs the fetal exposure to Bisphenol A

Glenn Gauderat , Nicole Picard-Hagen , Catherine Viguié , Sylvie Puel , Marlène Z. Lacroix et al.
13th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT), European Association for Veterinary Pharmacology and Toxicology (EAVPT). FRA., Jul 2015, Nantes, France. pp.176
Communication dans un congrès hal-02741104 v1

Pharmacodynamic/pharmacokinetic analysis of cephalexin activity on Staphylococcus aureus in a new in vitro model with and without macrophages

Elodie Lallemand , Aude Ferran , Claudine Zemirline , Pierre-Louis Toutain , Séverine Boullier et al.
13th. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT), European Association for Veterinary Pharmacology and Toxicology (EAVPT). FRA., Jul 2015, Nantes, France. pp.176
Communication dans un congrès hal-02742165 v1

Activity of antimicrobial monotherapy versus combination therapy against staphylococcus aureus biofilm in vitro.

Jingjing Liu , Alain Bousquet‐mélou , Pierre-Louis Toutain , Aude A Ferran
7th International Conference on Antimicrobial Agents in Veterinary Medicine, Antimicrobial Agents in Veterinary Medicine (AAVM). Berlin, DEU., Sep 2014, Berlin, Germany
Communication dans un congrès hal-02741090 v1

Influence of pasteurellaceae species and dose regimen on in vitro activity an in vivo efficacy of a fluoroquinolone treatment

Guillaume Lhermie , Aude Ferran , Farid El Garch , Gilles G. Meyer , Alain Bousquet‐mélou
7th International Conférence on Antimicrobial Agents in Veterinary Medicine ( AAVM), Antimicrobial Agents in Veterinary Medicine (AAVM). Berlin, DEU., Sep 2014, Berlin, Germany
Communication dans un congrès hal-02742843 v1

Les anciens antibiotiques sont-ils meilleurs que les nouveaux pour lutter contre l'antibiorésistance? Quand et comment utiliser les antibiotiques critiques?

Pierre-Louis Toutain , Aude Ferran , Elodie Lallemand , Alain Bousquet‐mélou
Journées Nationales des GTV, Société Nationale des Groupements Techniques Vétérinaires (SNGTV). Reims, FRA., May 2014, Reims, France
Communication dans un congrès hal-02741112 v1

Influence of marbofloxacin on the selection of bacterial resistances in the gut microbiota of veal calves. Investigation of a strategy aiming at reducing both selective pressure and resistance selection

Mouni Abdelli , Amandine Roques , Véronique Dupouy-Guiraute , Aude Ferran , Pierre-Louis Toutain et al.
7th International Conférence on Antimicrobial Agents in Veterinary Medicine ( AAVM), Antimicrobial Agents in Veterinary Medicine (AAVM). DEU., Sep 2014, BERLIN, Germany
Communication dans un congrès hal-02742567 v1
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Le concept "One Health" en antibiorésistance et les flux de gènes

Benoît Doublet , Alain Bousquet‐mélou , J.Y. Madec
Pour des aliments sains : savoir maîtriser les risques en alimentation, Nov 2012, Toulouse, France
Communication dans un congrès hal-02748843 v1
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Pharmacodynamic/pharmacokinetic analysis of marbofloxacin activity in plasma and in intestines of swine

Aude Ferran , Delphine Bibbal , Terence Pellet , Michel Laurentie , Mireille Gicquel-Bruneau et al.
12th International Congress of the European Association for Veterinary Pharmacology (EAVPT), Jul 2012, Noordwijkerhout, Netherlands. pp.1-182
Communication dans un congrès hal-02749268 v1

Emergence et diffusion de résistances aux antibiotiques en lien avec leur usage en élevage.

Alain Bousquet‐mélou
Salon International de l’Agriculture - « Anti-infectieux en élevage : Recherches et alternatives durables, 2012, PARIS, France
Communication dans un congrès hal-02802918 v1
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Licking behaviour affects the disposition of macrocyclic lactone pour-on formulations in cattle

Alain Bousquet‐mélou
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. 182 p
Communication dans un congrès hal-02747528 v1
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Differential activity of veterinary antibiotics on target pathogens versus digestive flora: development of a pharmacodynamic selectivity index for public health perspective

Maleck V. Vasseur , Aude Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
12th International Congress of the European Association for Veterinary Pharmacology (EAVPT), European Association for Veterinary Pharmacology and Toxicology (EAVPT). FRA., Jul 2012, Noordwijkehout, Netherlands. pp.1-182
Communication dans un congrès hal-02745409 v1
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Early versus later antibiotic treatments of pulmonary infections. A strategy to conciliate control of infectious diseases and reduction of antibiotic consumption

Alain Bousquet‐mélou , Aude Ferran , Maleck V. Vasseur , Pierre-Louis Toutain
6th International Conference on Antimicrobial Agents in Veterinary Medicine, Antimicrobial Agents in Veterinary Medicine (AAVM). DEU., Oct 2012, Washington, United States
Communication dans un congrès hal-02745067 v1
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Antimicrobial resistan ce of shiga toxin gene (stx)-positive and initimin gene (eae)-positive Escherichia coli isolates from wastewaters of an urban wastewater treatment plant (WWTP) collecting slaughterhouse effluents

Delphine Bibbal , Véronique Dupouy-Guiraute , Alpha Amadou Diallo , Monique Kérourédan , Nathalie Arpaillange et al.
3rd ASM Conference on Antimicrobial Resistance in Zoonotic Bacteria and Foodborne Pathogrens in Animals, Humans, and the Environmen, American Society for Microbiology. USA., Jun 2012, Aix-en-Provence, France
Communication dans un congrès hal-02746917 v1
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Prevalence and molecular characterization of CTX- M- producing Escherichia coli isolates from wastewaters of a couple slaughterhouse/wastewater treatment plant

Véronique Dupouy-Guiraute , Delphine Bibbal , Nathalie Arpaillange , Hubert Brugère , Eric Oswald et al.
4. Symposium on Antimicrobial Resistance in Animals and the Environment, Jun 2011, Tours, France
Communication dans un congrès hal-01577474 v1

Antibiotiques et médicaments génériques

Alain Bousquet‐mélou
Forum Antibiothérapie, Bayer SAS. Saisissez le nom du laboratoire, du service ou du département., Paris, FRA., May 2011
Communication dans un congrès hal-02802426 v1

Usage prudent des antibiotiques en médecine vétérinaire - Des traitements précoces à la métaphylaxie

Alain Bousquet‐mélou
Pfizer - Approche raisonnée de la prévention anti-infectieuse chez les Jeunes Bovins à l'engraissement, Laboratoire Pfizer. Saisissez le nom du laboratoire, du service ou du département., Paris, FRA., Jul 2011, Paris, France
Communication dans un congrès hal-02802086 v1

Effects of early versus late treatments by marbofloxacin in a mouse-model of Pasteurella multocida pulmonary infection

Aude Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
4.Symposium on Antimicrobial Resistance in Animals and the Environment, Jun 2011, Tours, France. pp.50
Communication dans un congrès hal-01191171 v1

Impact d'une antibiothérapie précoce sur l'efficacité de la marbofloxacine lors d'infection pulmonaire expérimentale à Pasteurella multocida

Aude Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journéés d'Animation Scientifique du Département Santé Animale, Institut National de Recherche Agronomique (INRA). UMR Toxicologie Alimentaire (1331)., May 2011, Fréjus, France
Communication dans un congrès hal-01191170 v1

La détermination d'un schéma thérapeutique pour un antibiotique

Alain Bousquet‐mélou , Aude Ferran , Pierre-Louis Toutain
Journées Nationales des GTV, May 2010, Lille, France
Communication dans un congrès hal-02754187 v1

Quelle voie choisir?

Alain Bousquet‐mélou
Journées Nationales des GTV, May 2010, Lille, France
Communication dans un congrès hal-02753190 v1

How biotic and abiotic stress affect growth and secondary metabolism in Mediterranean forest dynamic: a comparative case study of a pioneer (Pinus halepensis Mill) and a late successional species (Quercus pubescens Willd)

Yogan Monnier , B. Vila , Alain Bousquet‐mélou , Bernard Prévosto , C. Fernandez
4th SFB 607 Symposium, International Conference on Mechanisms of growth, competition and stress defense in plants, Freising, DEU, 1-3 March 2010, Mar 2010, Freising, Germany. pp.1
Communication dans un congrès hal-02596036 v1

Vite, fort, longtemps, est-ce toujours d'actualité ?

Aude Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journées Nationales des GTV, May 2010, Lille, France
Communication dans un congrès hal-02754663 v1

Influence of obesity on the pharmacokinetics of anthelmintic macrocyclic lactones in dogs

I Bargues , Anne Lespine , Pierre-Louis Toutain , Alain Bousquet‐mélou
11th International congress of the European Association for Veterinary Pharmacology and Toxicology, 2009, Leipzig, Germany
Communication dans un congrès hal-02752015 v1

Comment les stress biotiques et abiotiques affectent la croissance et le métabolisme secondaire dans la dynamique successionnelle méditerranéenne : étude comparative d'une espèce pionnière (Pinus halepensis Mill.) et d'une espèce de fin de succession (Quercus pubescens Willd.)

Yogan Monnier , B. Vila , Alain Bousquet‐mélou , S. Greff , N. Wisniewski et al.
6ème réunion du GDR Écologie Chimique, Marseille, 27-28 octobre 2009, Oct 2009, Marseille, France. pp.1
Communication dans un congrès hal-02596034 v1

A PK/PD analysis of the selection of marbofloxacin resistance in Escherichia coli in a mouse-thigh infection model

Aa Ferran , As Kesteman , Pierre-Louis Toutain , Alain Bousquet‐mélou
11th International congress of the European Association for Veterinary Pharmacology and Toxicology, 2009, Leipzig, Germany
Communication dans un congrès hal-02751289 v1

Influence of inoculum size and dosing regimen on the selection of marbofloxacin resistant mutants in experimental rat Klebsiella pneumoniae lung infection

As Kesteman , Aa Ferran , A Perrin-Guyomard , Michel Laurentie , Pascal Sanders et al.
11th International congress of the European Association for Veterinary Pharmacology and Toxicology, 2009, Leipzig, Germany
Communication dans un congrès hal-02751484 v1

Relatedness of ampicillin resistant Escherichia coli strains isolated from swine feces during ampicillin treatment

Delphine Bibbal , V Dupouy , Mf Prere , Pierre-Louis Toutain , Alain Bousquet‐mélou
3rd Symposium on Antimicrobial Resistance in Animals and the Environment, 2009, Tours, France. pp.Inconnu
Communication dans un congrès hal-02817938 v1

Relatedness of Ampicillin-resistant Escherichia coli strains isolated from pigs during ampicillin treatment

Delphine Bibbal , V Dupouy , Nathalie Arpaillange , Mf Prere , Pierre-Louis Toutain et al.
11th International congress of the European Association for Veterinary Pharmacology and Toxicology, 2009, Leipzig, Germany
Communication dans un congrès hal-02754492 v1

Impact d'une fluoroquinolone sur la flore pathogène et la flore commensale intestinale dans un modèle d'infection pulmonaire par Klebsiella pneumoniae chez le rat dixénique

As Kesteman , Aa Ferran , A Perrin-Guyomard , Michel Laurentie , Pascal Sanders et al.
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu
Communication dans un congrès hal-02822116 v1

Impact of marbofloxacin dosing regimen on intestinal flora in a dixenic rat model with Klebsiella pneumoniae lung infection

As Kesteman , Aa Ferran , A Perrin-Guyomard , Michel Laurentie , Pascal Sanders et al.
11th International congress of the European Association for Veterinary Pharmacology and Toxicology, 2009, Leipzig, Germany
Communication dans un congrès hal-02752387 v1

Relatedness of ampicillin resistant Escherichia coli strains isolated from pigs during ampicillin treatment

Delphine Bibbal , V Dupouy , Mf Prere , Pierre-Louis Toutain , Alain Bousquet‐mélou
4th International Conference on Antimicrobial Agents in Veterinary Medicine, 2008, Prague, Czech Republic. pp.Inconnu
Communication dans un congrès hal-02816620 v1

Effects of inoculum size on the selection of resistance in Escherichia coli by marbofloxacin in an in vitro pharmacodynamic model and in a mouse-thigh infection model

Aude Ferran , As Kesteman , Pierre-Louis Toutain , Alain Bousquet‐mélou
4th International Conference on Antimicrobial Agents in Veterinary Medicine, 2008, Prague, Czech Republic. pp.Inconnu
Communication dans un congrès hal-02816763 v1

Effects of inoculum size on the selection of marbofloxacin resistant mutants in experimental rat klebsiella pneumoniae lung infection

As Kesteman , Aude Ferran , A Perrin-Guyomard , Michel Laurentie , Pierre-Louis Toutain et al.
4th International Conference on Antimicrobial Agents in Veterinary Medicine, 2008, Prague, Czech Republic. pp.Inconnu
Communication dans un congrès hal-02811562 v1

Influence of inoculum size on the selection of marbofloxacin resistant mutants in experimental rat Klebsiella pneumoniae lung infection

As Kesteman , A Perin-Guyomard , Michel Laurentie , Alain Bousquet‐mélou , Pierre-Louis Toutain
4th International Conference on Antimicrobial Agents in Veterinary Medicine, 2008, Prague, Czech Republic. pp.Inconnu
Communication dans un congrès hal-02820035 v1

Influence of inoculum size on the selection of marbofloxacin resistant mutants in experimental rat Klebsiella pneumoniae lung infection

As Kesteman , Aude Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
2nd Symposium on Antimicrobial Resistance in Animals and the Environment, 2007, Tours, France. pp.Inconnu
Communication dans un congrès hal-02814585 v1

Pharmacologie : du nouveau-né à l'adulte

Alain Bousquet‐mélou
Journées Nationales des Groupements Techniques Vétérinaires (GTV), 2006, Dijon, France
Communication dans un congrès hal-02750991 v1

Impact of ampicillin administration on blaTEM genes excretion in swine stool

Delphine Bibbal , Alain Bousquet‐mélou , Véronique Dupouy-Guiraute , Jean-Pierre Ferré , Valérie Laroute et al.
3rd International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM), May 2006, Orlando, United States
Communication dans un congrès hal-02752014 v1

Impact of ampicillin administration on excretion of blaTEM genes in swine feces

Delphine Bibbal , Alain Bousquet‐mélou , V Dupouy , Mf Prere , O Fayet et al.
10th International Congress of the European Association for Veterinary Pharmacology and Toxicology, 2006, Turin, Italy. pp.Inconnu
Communication dans un congrès hal-02822925 v1

Propriétés pharmacocinétiques/pharmacodynamiques de la céfovécine : perspective du pharmacologue

Alain Bousquet‐mélou
Congrès AFVAC, 2006, Bordeaux, France. pp.Inconnu
Communication dans un congrès hal-02811806 v1

Quantification of blaTEM genes in swine stool by real-time PCR

V Dupouy , Delphine Bibbal , Alain Bousquet‐mélou , Mf Prere , O Fayet et al.
3rd International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM), 2006, Orlando, United States
Communication dans un congrès hal-02751609 v1

How antibiotic dosage regimens based on PK-PD concepts may be an important contribution to the resistance problem

Pierre-Louis Toutain , Alain Bousquet‐mélou
24th World Buiatrics Congress, 2006, Nice, France
Communication dans un congrès hal-02750614 v1

Evolution de la résistance aux antibiotiques des E coli de la flore fécale au cours d'un traitement à l'ampicilline : étude quantitative voie orale versus voie intramusculaire chez 12 porcelets

Delphine Bibbal , D Fajadet , V Dupouy , Alain Bousquet‐mélou , Pierre-Louis Toutain et al.
25e Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse, 2005, Paris, France. pp.Inconnu
Communication dans un congrès hal-02828300 v1

Population pharmacokinetics of marbofloxacin in horses

M Peyrou , My Doucet , A Vrins , M Schneider , Didier Concordet et al.
2nd International Conference on Antimicrobial Agents in Veterinary Medicine, 2004, Ottawa, Canada. pp.Inconnu
Communication dans un congrès hal-02825659 v1

Ecotoxicological bioassay on ivermectin with the MI bioindicator system: changes in the structure of nematode communities of cattle dung

G Gauthier , C Gers , M Alvinerie , Alain Bousquet‐mélou
14th International Colloquium on Soil Zoology and Ecology, 2004, Rouen, France. pp.Inconnu
Communication dans un congrès hal-02826658 v1

Pharmacokinetics of an oral commercial formulation of marbofloxacin in horses

M Peyrou , My Doucet , A Vrins , Valérie Laroute , Alain Bousquet‐mélou
43rd Annual Congress of the British Equine Veterinary Association, 2004, Birmingham, United Kingdom. pp.Inconnu
Communication dans un congrès hal-02825372 v1

Intestinal lymphatic transport of moxidectin in conscious lymph duct-cannulated dogs

Anne Lespine , G Chanoit , Alain Bousquet‐mélou , Elodie Lallemand , F Bassissi et al.
EUFEPS Conferences 3rd World Conference on Drug Absorption Transport and delivery, 2004, Barcelona, Spain. pp.Inconnu
Communication dans un congrès hal-02827582 v1

Pharmacokinetics in drug development: beyond single models

Pierre-Louis Toutain , Alain Bousquet‐mélou
13th Biennial Symposium of the American Academy of Veterinary Pharmacology and Therapeutics, 2003, Charlotte, United States
Communication dans un congrès hal-02758750 v1

Drug transfer between grazing cattle after topical administration of doramectin, ivermectin and moxidectin

Alain Bousquet‐mélou , S. Mercadier , Nadine Gautier , M. Alvinerie , Pierre-Louis Toutain
9. International Congress of the European Association for Veterinary Pharmacology and Toxicology, European Association for Veterinary Pharmacology and Toxicology (EAVPT). FRA., Jul 2003, Lisbonne, Portugal. 307 p., ⟨10.1046/j.1365-2885.25.s1.1.x⟩
Communication dans un congrès istex hal-02762208 v1

Comparative evaluation of P-glycoprotein activity in horses, pigs, cattle, sheep, goats and rats using a lymphocyte-based ex vivo model

C Laffont , G de Vrieze , Roeland Marinus Maas , Alain Bousquet‐mélou , J Fink Gremmels
9th International Congress of the European Association for Veterinary Pharmacology and Toxicology, 2003, Lisbon, Portugal
Communication dans un congrès hal-02760354 v1

Population pharmacokinetics of marbofloxacin in horses Preliminary results of mixed-effect modelling

Alain Bousquet‐mélou , P Bourdaud'Hui , Didier Concordet , C Tetot , Y Tamzali et al.
9th International Congress of the European Association for Veterinary Pharmacology and Toxicology, 2003, Lisbon, Portugal. pp.Inconnu
Communication dans un congrès hal-02830489 v1

Putative prediction of macrocyclic lactones in vivo-disposition using an original pharmacological parameter [Vp50] obtained from transport experiments in P-glycoprotein-expressing cells

Alain Roulet , Alain Bousquet‐mélou , Didier Concordet , Jacques Dupuy , Anne Lespine et al.
19th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2003, New Orleans, United States. pp.Inconnu
Communication dans un congrès hal-02829726 v1

Relevance of kinetic concepts to interpret a plasma concentration in clinical biochemistry (clearance, production rate, binding, half-life)

P.L. Toutain , H.P. Lefebvre , Alain Bousquet‐mélou
9. Congrès Société Internationale de Biochimie Clinique Animale, Jul 2000, Toulouse, France
Communication dans un congrès hal-02835244 v1

Repeated exposure of Escherichia coli to high ciprofloxacin concentrations selects gyrB mutants that show fluoroquinolone-specific hyperpersistence

Aurore Perault , Catherine Turlan , Nathalie Eynard , Quentin Vallé , Alain Bousquet-Melou et al.
European Congress of Clinical Microbiology & Infection Diseases (ECCMID), Apr 2022, Lisbon, Portugal. Front Microbiol ., 13, pp.908296, 2022, ⟨10.3389/fmicb.2022.908296⟩
Poster de conférence hal-04955164 v1

Original use of a hollow-fiber infection model to investigate a 5-days antibiotic combination against Staphylococcus aureus biofilm

Diane Broussou , Marlène Z. Lacroix , P. L. Toutain , F. Woehrle , F. E. Garch et al.
14. International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jun 2018, Wroclaw, Poland. Wiley-Blackwell, Journal of Veterinary Pharmacology and Therapeutics, 41, pp.1, 2018, Special Issue: 14th International Congress of the European Association for Veterinary Pharmacology and Toxicology
Poster de conférence hal-02736590 v1

Efficacy, effectiveness and efficiency of an alternative treatment protocol of bovine respiratory disease with reduced amount of antimicrobials

Guillaume Lhermie , Alain Bousquet‐mélou , Gilles G. Meyer , Henri Seegers , Sébastien Assie
29. World Buiatrics Congress (WBC), Jul 2016, Dublin, Ireland. 728 p., 2016, World Buiatrics Congress (WBC)
Poster de conférence hal-02742845 v1

Impact of a cephalosporin treatment on the selection and transfer of blacTX-M résistance gene in pig intestine

Véronique Dupouy-Guiraute , Nathalie Arpaillange , Edwige Tapie , Vona Dimbimanana , Alain Bousquet‐mélou
6th Symposium on Antimicrobial Résistance in Animals and the Environment (ARAE), Jun 2015, TOURS, France. , 2015
Poster de conférence hal-02797320 v1

Impact of early versus later beta-lactam treatments on clinical and microbiological outcomes in an original mouse model of airborne <em>Pasteurella multocida</em> lung infection

Maleck V. Vasseur , Aude Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. Wiley-Blackwell, Journal of Veterinary Pharmacology and Therapeutics, 35 (Suppl. 3), 182 p., 2012, Abstracts of the 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012)
Poster de conférence hal-02747497 v1

Etude d'un effet inoculum sur l'activité bactéricide de deux bêta-lactamines visà vis de Pasteurella multocida et Escherichia coli

Maleck V. Vasseur , Aude Ferran , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journées d'Animation scientifiques du Départment de Santé Animale, May 2011, Fréjus, France. pp.1, 2011
Poster de conférence hal-01191176 v1

Influence of inoculum size and dosing regimen on the selection of marbofloxacin resistant mutants in experimental Klebsiella pneumonia lung infection in rats

As Kesteman , Aude Ferran , A Perrin-Guyomard , Michel Laurentie , Pascal Sanders et al.
3rd Symposium on Antimicrobial Resistance in Animals and the Environment, 2009, Tours, France. pp.Inconnu, 2009
Poster de conférence hal-02815427 v1

Caractérisation de l'impact des beta-lactamines sur l'émergence de bactéries résistantes dans la flore fécale chez le porc

Delphine Bibbal , V Dupouy , Nathalie Arpaillange , Mf Prere , Pierre-Louis Toutain et al.
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009
Poster de conférence hal-02822573 v1

A PK/PD analysis of the selection of resistance to marbofloxacin in Escherichia coli in a mouse-thigh infection model

Aude Ferran , As Kesteman , Pierre-Louis Toutain , Alain Bousquet‐mélou
3rd Symposium on Antimicrobial Resistance in Animals and the Environment, 2009, Tours, France. pp.Inconnu, 2009
Poster de conférence hal-02815199 v1

Antimicrobial resistance in Escherichia coli strains carrying virulence genes isolated in wastewater of slaughterhouses in France

Delphine Bibbal , Estelle Loukiadis , Monique Kérourédan , Nathalie Arpaillange , V Dupouy et al.
3rd Symposium on Antimicrobial Resistance in Animals and the Environment, 2009, Tours, France. pp.Inconnu, 2009
Poster de conférence hal-02823666 v1

Influence de la taille de l'inoculum bactérien sur la sélection de bactéries résistantes lors d'exposition in vitro et in vivo à la marbofloxacine

Aude Ferran , As Kesteman , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009
Poster de conférence hal-02816105 v1

Analysis of antimicrobial resistance transfer by conjugation from Escherichia coli strains selected by ampicillin treatment in pig feces

V Dupouy , Delphine Bibbal , Nathalie Arpaillange , Mf Prere , Pierre-Louis Toutain et al.
3rd Symposium on Antimicrobial Resistance in Animals and the Environment, 2009, Tours, France. pp.Inconnu, 2009
Poster de conférence hal-02819607 v1

Effet de la taille de l'inoculum bactérien sur la sélection de mutants résistants lors d'exposition in vitro d'Escherichia coli à la marbofloxacine

Aude Ferran , V Dupouy , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journées d’Animation Scientifique du Département de Santé Animale, 2007, Tours, France. pp.Inconnu, 2007
Poster de conférence hal-02815554 v1

Impact de l'administration d'ampicilline sur l'excrétion fécale de gènes blaTEM chez le porc

Delphine Bibbal , V Dupouy , Jp Ferre , Pierre-Louis Toutain , Mf Prere et al.
Journées d’Animation Scientifique du Département de Santé Animale, 2007, Tours, France. pp.Inconnu, 2007
Poster de conférence hal-02816203 v1

Putative prediction of macrocyclic lactones in vivo-disposition using an original pharmacological parameter (Vp50) obtained from transport experiments in P-glycoprotein-expressing cells

Alain Roulet , Alain Bousquet‐mélou , Didier Concordet , Jacques Dupuy , Anne Lespine et al.
19th International Conference of the World Association for the Advancement of Veterinary Parasitology, 2003, New Orleans, United States. pp.Inconnu, 2003
Poster de conférence hal-02829746 v1

O73 | Determination of the pharmacokinetic parameters of 4 formulations of penicillin G in order to optimize the first‐line antibiotic treatment in horses

Elodie A Lallemand , Alain Bousquet-Mélou , Laura Chapuis , Aude A. Ferran , Taisuke Kuroda et al.
15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jul 2023, Bruges, Belgium. Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.64-64, 2023, ⟨10.1111/jvp.13239⟩
Proceedings/Recueil des communications hal-04352514 v1

I25 | Reassessment of class D antimicrobials of the AMEG classification: What data needs to be generated for optimal use of old antibiotics?

Aude A. Ferran , Alain Bousquet-Mélou
15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.18-19, 2023, ⟨10.1111/jvp.13155⟩
Proceedings/Recueil des communications hal-04352497 v1

O86 | Combination of antibiotic and bacteriophages to prevent the selection of resistant <i>Pseudomonas aeruginosa</i>

Aude A. Ferran , Marlène Lacroix , Ophelie Gourbeyre , Alicia Huesca , Laurent Debarbieux et al.
15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.70-71, 2023, ⟨10.1111/jvp.13252⟩
Proceedings/Recueil des communications hal-04352521 v1

P17 | In vitro evaluation of the activity of antibiotics against <i>Rhodococcus equi</i> at pH and concentrations representative of intracellular conditions

Aude A. Ferran , Ophelie Gourbeyre , Charline Philibert , Elodie A Lallemand , Alain Bousquet-Mélou
15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jul 2023, Bruges, Belgium. Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.93-93, 2023, ⟨10.1111/jvp.13296⟩
Proceedings/Recueil des communications hal-04352568 v1

Species differences in pharmacokinetics and pharmacodynamics

Pierre-Louis Toutain , Aude Ferran , Alain Bousquet‐mélou
Comparative and veterinary pharmacology, 199, Springer-Verlag, 2010, Handbook of Experimental Pharmacology, 978-3-642-10323-0. ⟨10.1007/978-3-642-10324-7_2⟩
Chapitre d'ouvrage hal-02824844 v1