Antoine CLAESSENS

Head of équipe FRM 'GATAC-Malaria'. I like everything that is P. falciparum related, but I can't hide my love for var genes.
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Libre accès
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Affiliation actuelle
  • Laboratory of Pathogen and Host Immunity [Montpellier] (LPHI)

Présentation

Antoine Claessens https://lphi.umontpellier.fr/research-teams/genomic-approaches-to-asymptomatic-chronic-malaria/ Chargé de Recherche INSERM Head of équipe FRM GATAC-Malaria LPHI (UMR5294), Bat 24, cc107 CNRS/Université Montpellier Place Eugène Bataillon 34095 Montpellier cedex 5 France

EDUCATION

2000-2004: **University of Liège, Belgium, 4-year degree (MSc) in biochemistry 2004-2004: **University of Cambridge, UK, 6-month undergraduate project in developmental biology of Drosophila, supervised by Steve Russell, Ashburner group 2005-2006: **University of Edinburgh, UK. Master in Life Sciences: The molecular basis of disease.

** MALARIA CAREER** 2006-2011: Wellcome Trust PhD thesis with Alex Rowe at Edinburgh University, and Zbynek Bozdech at NTU-Singapore 2011: Short contract with Pierre Buffet at Pitié-Salpêtrière. 2011-2014: Postdoc with Dominic Kwiatkowski at the Sanger Institute and in Oxford University (UK) 2014-2017: MRC-Fellowship joint London School of Hygiene and Tropical Medicine / MRC-Gambia, The Gambia 2018: Chargé de Recherche INSERM at LPHI, Montpellier, France

		   **GRANTS**

 2019 - 2021: ATIP-Avenir from CNRS – INSERM  2019 - 2023: ANR-JCJC personal grant: Based in LPHI, Montpellier, France € 446,000  2019: CNRS Transverse: Funding for a 3-year PhD student (M-A Guéry) € 81,000  2019: InfectioPole Sud / Méditérannée Infection: Funding for a 3-year PhD student € 40,000  2020: MUSE-Explore: Collaborative project with Texas BioMed, USA € 32,000  2021: LabEx ParaFrap: Selected member of the consortium € 10,000  2021: CNRS-Afrique: Initiating a collaboration with Centre Pasteur Cameroun € 19,000  2021: ATIP-Avenir renewal: Core funding for 2022 and 2023 € 60,000  2022: ITMO I3M: Initiating a ‘Projet Amorçage’ in Cameroon (Centre Pasteur) € 15,000  2022: Inserm First Step: Initiating a collaboration with Ian Cheeseman, Texas bioMed € 10,000  2022: InfectioPole Sud: Funding for a one-year post-doc € 50,000  2022: ANR-PRC: project MADBIO, coordinated by S Marquet (Marseille); 693k total. € 283,500  2022: Muse Pre-ERC: 18months postdoc + consumables. € 132,000  2023: INSB-Structure: Funding for a collaboration with sequencing platform MGX € 29,000  2024-2026: Equipe-FRM: Core funding secured for MADBIO-Ghana project € 448,500  2022: InfectioPole Sud: Funding for a one-year post-doc (to be recruited) € 50,000

** Member of MalariaGEN and ParaFrap consortium.**

Domaines de recherche

Génomique, Transcriptomique et Protéomique [q-bio.GN] Génétique des populations [q-bio.PE] Parasitologie

Publications

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Publications

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Detection of novel Plasmodium falciparum haplotypes under treatment pressure in paediatric severe malaria

Balotin Fogang , Emilie Guillochon , Claire Kamaliddin , Gino Agbota , Sem Ezinmegnon et al.

Microbial Genomics, 2025, 11 (5), ⟨10.1099/mgen.0.001386⟩

Article dans une revue hal-05247486v1
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An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP

Marie Ali , Rea Dura , Marc-Antoine Guery , Emma Colard-Itté , Thomas Cheviet et al.

Science Advances , 2025, 11 (47), pp.eady2859. ⟨10.1126/sciadv.ady2859⟩

Article dans une revue hal-05387607v1
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RNA polymerase III is involved in regulating Plasmodium falciparum virulence

Gretchen Diffendall , Aurelie Claes , Anna Barcons-Simon , Prince Nyarko , Florent Dingli et al.

eLife, 2024, 13, pp.95879. ⟨10.7554/elife.95879⟩

Article dans une revue hal-04652238v1
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Asymptomatic Plasmodium falciparum carriage at the end of the dry season is associated with subsequent infection and clinical malaria in Eastern Gambia

Balotin Fogang , Lionel Lellouche , Sukai Ceesay , Sainabou Drammeh , Fatou Jaiteh et al.

Malaria Journal, 2024, 23 (1), 22 [12p.]. ⟨10.1186/s12936-024-04836-y⟩

Article dans une revue hal-04795643v1

Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia

Marc-Antoine Guery , Sukai Ceesay , Sainabou Drammeh , Fatou Jaiteh , Umberto D’alessandro et al. Article dans une revue hal-04843159v1

Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis

Olivo Miotto , Alfred Amambua-Ngwa , Lucas Amenga-Etego , Muzamil Abdel Hamid , Ishag Adam et al.

The Lancet Microbe, 2024, 5 (12), pp.100941. ⟨10.1016/j.lanmic.2024.07.004⟩

Article dans une revue hal-04843190v1
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Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

Muzamil Mahdi Abdel Hamid , Mohamed Hassan Abdelraheem , Desmond Omane Acheampong , Ambroise Ahouidi , Mozam Ali et al.

Wellcome Open Research, 2023, 8, pp.22. ⟨10.12688/wellcomeopenres.18681.1⟩

Article dans une revue hal-04110334v1
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Genomic variation during culture adaptation of genetically complex Plasmodium falciparum clinical isolates

Antoine Claessens , Lindsay B Stewart , Eleanor Drury , Ambroise D Ahouidi , Alfred Amambua-Ngwa et al.

Microbial Genomics, 2023, 9 (5), ⟨10.1099/mgen.0.001009⟩

Article dans une revue hal-04109945v1

Genetic Diversity of Plasmodium falciparum and Distribution of Antimalarial Drug Resistance Mutations in Symptomatic and Asymptomatic Infections

Elangwe Sarah-Matio , Emilie Guillochon , Sandrine Nsango , Luc Abate , Christelle Ngou Maffo et al.

Antimicrobial Agents and Chemotherapy, 2022, 66 (8), ⟨10.1128/aac.00188-22⟩

Article dans une revue hal-03873724v1
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A Cohort Study on the Duration of <i>Plasmodium falciparum</i> Infections During the Dry Season in The Gambia

Katharine Collins , Sukai Ceesay , Sainabou Drammeh , Fatou Jaiteh , Marc-Antoine Guery et al.

Journal of Infectious Diseases, In press, ⟨10.1093/infdis/jiac116⟩

Article dans une revue hal-03664364v1
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Order within chaos: Harnessing Plasmodium falciparum var gene extreme polymorphism for malaria epidemiology

Marc-Antoine Guery , Antoine Claessens

PLoS Genetics, 2021, 17 (2), pp.e1009344. ⟨10.1371/journal.pgen.1009344⟩

Article dans une revue hal-03228641v1
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Understanding Host–Pathogen–Vector Interactions with Chronic Asymptomatic Malaria Infections

Prince B Nyarko , Antoine Claessens

Trends in Parasitology, 2021, 37 (3), pp.195-204. ⟨10.1016/j.pt.2020.09.017⟩

Article dans une revue hal-02981651v1
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An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

Ambroise Ahouidi , Mozam Ali , Jacob Almagro-Garcia , Alfred Amambua-Ngwa , Chanaki Amaratunga et al.

Wellcome Open Research, 2021, 6, pp.42. ⟨10.12688/wellcomeopenres.16168.1⟩

Article dans une revue hal-03228653v1
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Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites

Lindsay B Stewart , Ofelia Diaz-Ingelmo , Antoine Claessens , James Abugri , Richard D Pearson et al.

Communications Biology, 2020, 3, pp.624. ⟨10.1038/s42003-020-01349-7⟩

Article dans une revue hal-03152246v1
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Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres

Thomas Otto , Ulrike Böhme , Mandy Sanders , Adam Reid , Ellen I Bruske et al.

Wellcome Open Research, 2018, 3, pp.52. ⟨10.12688/wellcomeopenres.14571.1⟩

Article dans une revue hal-01989283v1
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RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics

Antoine Claessens , Lynne M Harris , Slavica Stanojcic , Lia Chappell , Adam Stanton et al.

PLoS Genetics, 2018, 14 (7), pp.e1007490. ⟨10.1371/journal.pgen.1007490⟩

Article dans une revue hal-01989183v1
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Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

Antoine Claessens , Muna Affara , Samuel A Assefa , Dominic Kwiatkowski , David J Conway

Scientific Reports, 2017, 7, pp.41303. ⟨10.1038/srep41303⟩

Article dans une revue hal-01989281v1
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Extreme mutation bias and high AT content in Plasmodium falciparum

William L Hamilton , Antoine Claessens , Thomas Otto , Mihir Kekre , Rick M Fairhurst et al.

Nucleic Acids Research, 2016, pp.gkw1259. ⟨10.1093/nar/gkw1259⟩

Article dans une revue hal-01989279v1
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Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis

Antoine Claessens , William L Hamilton , Mihir Kekre , Thomas Otto , Adnan Faizullabhoy et al.

PLoS Genetics, 2014, 10 (12), pp.e1004812. ⟨10.1371/journal.pgen.1004812⟩

Article dans une revue hal-01989273v1

Plasmodium falciparum Clearance Is Rapid and Pitting Independent in Immune Malian Children Treated With Artesunate for Malaria

Papa Alioune Ndour , Tatiana M Lopera-Mesa , Seidina Diakité , Serena Chiang , Oussama Mouri et al.

Journal of Infectious Diseases, 2014, 211 (2), pp.290-297. ⟨10.1093/infdis/jiu427⟩

Article dans une revue hal-01989275v1
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Optimized Whole-Genome Amplification Strategy for Extremely AT-Biased Template

Samuel Oyola , Magnus Manske , Susana Campino , Antoine Claessens , William L Hamilton et al.

DNA Research, 2014, 21 (6), pp.661-671. ⟨10.1093/dnares/dsu028⟩

Article dans une revue hal-01989274v1
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Induction of Strain-Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites

Ashfaq Ghumra , Jean-Philippe Semblat , Ricardo Ataide , Carolyne Kifude , Yvonne Adams et al.

PLoS Pathogens, 2012, 8 (4), pp.e1002665. ⟨10.1371/journal.ppat.1002665⟩

Article dans une revue hal-01989271v1
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Selection of <em>Plasmodium falciparum</em> Parasites for Cytoadhesion to Human Brain Endothelial Cells

Antoine Claessens , J. Alexandra Alexandra Rowe

Journal of visualized experiments : JoVE, 2012, 59, ⟨10.3791/3122⟩

Article dans une revue hal-01989269v1
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Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes

Antoine Claessens , Ashfaq Ghumra , Archna P Gupta , Sachel Mok , Zbynek Bozdech et al.

Malaria Journal, 2011, 10 (1), pp.180. ⟨10.1186/1475-2875-10-180⟩

Article dans une revue hal-04109883v1

Adhesion of Plasmodium falciparum -infected erythrocytes to human cells: molecular mechanisms and therapeutic implications

J Alexandra Rowe , Antoine Claessens , Ruth Corrigan , Mònica Arman

Expert Reviews in Molecular Medicine, 2009, 11, pp.e16. ⟨10.1017/S1462399409001082⟩

Article dans une revue hal-04208631v1

DISC1, PDE4B, and NDE1 at the centrosome and synapse

Nicholas J Bradshaw , Fumiaki Ogawa , Beatriz Antolin-Fontes , Jennifer E Chubb , Becky C Carlyle et al.

Biochemical and Biophysical Research Communications, 2008, 377 (4), pp.1091-1096. ⟨10.1016/j.bbrc.2008.10.120⟩

Article dans une revue istex hal-01989255v1