Antoine Rimbert

45
Documents
Identifiants chercheurs

Publications

Publications

Casz1 and Znf101/Zfp961 differentially regulate apolipoproteins A1 and B, alter plasma lipoproteins, and reduce atherosclerosis

Abulaish Ansari , Pradeep Kumar Yadav , Liye Zhou , Binu Prakash , Laraib Ijaz et al.
JCI Insight, 2025, 10 (1), pp.e182260. ⟨10.1172/jci.insight.182260⟩
Article dans une revue hal-04902459 v1

A study into rare GPR146 gene variants in humans and mice

Boyan Zhang , Antoine Rimbert , Antoine Lainé , Nicolette Huijkman , Niels Kloosterhuis et al.
Atherosclerosis, 2025, 403, pp.119137. ⟨10.1016/j.atherosclerosis.2025.119137⟩
Article dans une revue hal-05018648 v1

From Genetic Findings to new Intestinal Molecular Targets in Lipid Metabolism

Cédric Le May , Simon Ducheix , Bertrand Cariou , Antoine Rimbert
Current Atherosclerosis Reports, 2025, 27 (1), pp.26. ⟨10.1007/s11883-024-01264-w⟩
Article dans une revue hal-04902458 v1

Advancements in risk stratification and management strategies in primary cardiovascular prevention

Fotios Barkas , Yusuf Ziya Sener , Pelin Arabacilar Golforoush , Azin Kheirkhah , Elena Rodriguez-Sanchez et al.
Atherosclerosis, 2024, 395, pp.117579. ⟨10.1016/j.atherosclerosis.2024.117579⟩
Article dans une revue hal-04751122 v1

Variants in LPA are associated with familial hypercholesterolaemia: whole genome sequencing analysis in the 100 000 Genomes Project

Martin Bird , Antoine Rimbert , Alan Michael Pittman , Steve Eric Humphries , Marta Futema
European Journal of Preventive Cardiology, 2024, ⟨10.1093/eurjpc/zwae371⟩
Article dans une revue hal-04902463 v1
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Human induced pluripotent stem cells ‐derived liver organoids grown on a Biomimesys® hyaluronic acid‐based hydroscaffold as a new model for studying human lipoprotein metabolism

Meryl Roudaut , Amandine Caillaud , Zied Souguir , Lise Bray , Aurore Girardeau et al.
Bioengineering & Translational Medicine, 2024, ⟨10.1002/btm2.10659⟩
Article dans une revue (data paper) hal-04509118 v1
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MicroRNA-615-3p decreases apo B expression in human liver cells

Abulaish Ansari , Pradeep Kumar Yadav , Swati Valmiki , Antoine Laine , Antoine Rimbert et al.
Journal of Lipid Research, 2024, 65 (10), pp.100659. ⟨10.1016/j.jlr.2024.100659⟩
Article dans une revue hal-04751117 v1
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Primary hypocholesterolemia is associated with an increased risk of hepatic complications in the general population

Matthieu Wargny , Thomas Goronflot , Antoine Rimbert , Jérôme Boursier , Sofiane Kab et al.
Journal of Hepatology, 2024, 80 (6), pp.846-857. ⟨10.1016/j.jhep.2024.01.030⟩
Article dans une revue hal-04474613 v2
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Reply to “The association between primary hypobetalipoproteinemia and hepatic diseases: evidence from genetic studies”

Antoine Rimbert , Matthieu Wargny , Bertrand Cariou
Journal of Hepatology, In press, Online ahead of print. ⟨10.1016/j.jhep.2024.09.009⟩
Article dans une revue hal-04751118 v1
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DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice

Xiaoke Ge , Bram Slütter , Joost Lambooij , Enchen Zhou , Zhixiong Ying et al.
iScience, 2024, 27 (6), pp.109830. ⟨10.1016/j.isci.2024.109830⟩
Article dans une revue hal-04751124 v1
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PCSK9 inhibition protects mice from food allergy

Victoria Lorant , Martin Klein , Damien Garçon , Thibaud Sotin , Samuel Frey et al.
Translational Research, The Journal of Laboratory and Clinical Medicine, 2024, 272, pp.151-161. ⟨10.1016/j.trsl.2024.03.001⟩
Article dans une revue hal-04529957 v1
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G protein-coupled receptor 146: new insights from genetics and model systems

Umesh Tharehalli , Antoine Rimbert
Current Opinion in Lipidology, 2024, ⟨10.1097/MOL.0000000000000929⟩
Article dans une revue hal-04529967 v1

A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolemia

Xavier Vanhoye , Claire Bardel , Antoine Rimbert , Philippe Moulin , Pierre-Antoine Rollat-Farnier et al.
Translational Research, The Journal of Laboratory and Clinical Medicine, 2023, 255, pp.119-127. ⟨10.1016/j.trsl.2022.12.002⟩
Article dans une revue hal-04172500 v1
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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

Sebastian Hendrix , Jenina Kingma , Roelof Ottenhoff , Masoud Valiloo , Monika Svecla et al.
Nature Communications, 2023, 14 (1), pp.5181. ⟨10.1038/s41467-023-40943-1⟩
Article dans une revue hal-04208487 v1
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Generation of an induced pluripotent stem cell line (ITXi012-A) from a patient with genetically determined high-lipoprotein(a) plasma levels

Amandine Caillaud , Lise Bray , Aurore Girardeau , Zoé Begué-Racapé , Lucie Vince et al.
Stem Cell Research, 2023, 72, ⟨10.1016/j.scr.2023.103205⟩
Article dans une revue hal-04212298 v1
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Germline JAK2 E846D Substitution as the Cause of Erythrocytosis?

Nada Maaziz , Céline Garrec , Fabrice Airaud , Victor Bobée , Nathalie Contentin et al.
Genes, 2023, 14 (5), pp.1066. ⟨10.3390/genes14051066⟩
Article dans une revue hal-04208496 v1
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LDL lowering effect of PCSK9 inhibition is reduced in women

Veronika Myasoedova , Antoine Rimbert , Marina Camera , Cedric Le May , Romain Capoulade et al.
European Heart Journal - Cardiovascular Pharmacotherapy, 2023, 9 (4), pp.337-342. ⟨10.1093/ehjcvp/pvad009⟩
Article dans une revue hal-04212334 v1
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Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity : a cross sectional study in the population-based LifeLines DEEP cohort

Anouk Groenen , Venetia Bazioti , Isabelle van Zeventer , Lianmin Chen , Hilde Groot et al.
Atherosclerosis, 2022, 343, pp.20-27. ⟨10.1016/j.atherosclerosis.2022.01.008⟩
Article dans une revue hal-04060061 v1
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The Genetic Spectrum of Familial Hypertriglyceridemia in Oman

Khalid Al-Waili , Khalid Al-Rasadi , Muna Al-Bulushi , Mohammed Habais , Abdullah Al-Mujaini et al.
Frontiers in Genetics, 2022, 13, ⟨10.3389/fgene.2022.886182⟩
Article dans une revue hal-04060049 v1
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Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia

Wieneke Dijk , Mathilde Di-Filippo Charcosset , Sander Kooijman , Robin Van Eenige , Antoine Rimbert et al.
Circulation, 2022, 146 (10), pp.724-739. ⟨10.1161/circulationaha.121.057978⟩
Article dans une revue inserm-03831077 v1
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Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome

Paolo Zanoni , Grigorios Panteloglou , Alaa Othman , Joël T. Haas , Roger Meier et al.
Circulation Research, 2022, 130 (1), pp.80-95. ⟨10.1161/CIRCRESAHA.120.318141⟩
Article dans une revue hal-03554168 v1
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FACS-assisted CRISPR-Cas9 genome editing of human induced pluripotent stem cells

Amandine Caillaud , Antoine Lévêque , Aurélie Thédrez , Aurore Girardeau , Robin Canac et al.
STAR Protocols, 2022, 3 (4), pp.101680. ⟨10.1016/j.xpro.2022.101680⟩
Article dans une revue hal-04060050 v1
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Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Willemien van Zwol , Antoine Antoine Rimbert , Justina C Wolters , Marieke Smit , Vincent W Bloks et al.
Hepatology, 2022, 23 (8), pp.n/a-n/a. ⟨10.1002/hep.32709⟩
Article dans une revue hal-04060059 v1
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APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants

Xavier Vanhoye , Alexandre Janin , Amandine Caillaud , Antoine Rimbert , Fabienne Venet et al.
International Journal of Molecular Sciences, 2022, 23 (8), pp.4281. ⟨10.3390/ijms23084281⟩
Article dans une revue hal-03659209 v1
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Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

Sandrine Morel , Isabel Hostettler , Georg Spinner , Romain Bourcier , Joanna Pera et al.
Journal of Personalized Medicine, 2022, 12 (9), pp.1410. ⟨10.3390/jpm12091410⟩
Article dans une revue hal-04060055 v1

In silico and Functional Studies for Classification of EPAS1/HIF2A Genetic Variants Identified in Patients with Erythrocytosis

Valéna Karaghiannis , Darko Maric , Céline Garrec , Nada Maaziz , Alexandre Buffet et al.
Blood, 2022, 140 (Supplement 1), pp.8157-8158. ⟨10.1182/blood-2022-163123⟩
Article dans une revue hal-04031832 v1
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Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1)

Lise Bray , Amandine Caillaud , Aurore Girardeau , Murielle Patitucci , Cédric Le May et al.
Stem Cell Research, 2022, 60, pp.102721. ⟨10.1016/j.scr.2022.102721⟩
Article dans une revue hal-03869113 v1
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A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis

Cristy R.C. Verzijl , Federico Oldoni , Natalia Loaiza , Justina Wolters , Antoine Rimbert et al.
Molecular metabolism, 2022, 60 (1), pp.101472. ⟨10.1016/j.molmet.2022.101472⟩
Article dans une revue hal-04060053 v1
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Genetic Inhibition of PCSK9 and Liver Function

Antoine Rimbert , Sarra Smati , Wieneke Dijk , Cedric Le May , Bertrand Cariou
JAMA Cardiology, 2021, ⟨10.1001/jamacardio.2020.5341⟩
Article dans une revue hal-03100949 v1
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PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs

Meryl Roudaut , Salam Idriss , Amandine Caillaud , Aurore Girardeau , Antoine Rimbert et al.
Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.10.004⟩
Article dans une revue hal-03451184 v1
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Phenotypic Differences Between Polygenic and Monogenic Hypobetalipoproteinemia

Antoine Rimbert , Xavier Vanhoye , Dramane Coulibaly , Marie Marrec , Matthieu Pichelin et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41 (1), pp.e63-e71. ⟨10.1161/ATVBAHA.120.315491⟩
Article dans une revue hal-03105646 v1
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Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study

Bertrand Cariou , Thomas Goronflot , Antoine Rimbert , Sandrine Boullu , Cedric Le May et al.
Journal of Diabetes & Metabolism, 2021, 47 (2), pp.101202. ⟨10.1016/j.diabet.2020.10.001⟩
Article dans une revue hal-03100948 v1
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Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study

Bertrand Cariou , Thomas Goronflot , Antoine Rimbert , Sandrine Boullu , Cédric Le May et al.
Journal of Diabetes & Metabolism, 2020, ⟨10.1016/j.diabet.2020.10.001⟩
Article dans une revue hal-02977495 v1
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Comprehensive <i>in silico</i> and functional studies for classification of <i>EPAS1/HIF2A</i> genetic variants identified in patients with erythrocytosis

Valéna Karaghiannis , Darko Maric , Céline Garrec , Nada Maaziz , Alexandre Buffet et al.
Article dans une revue hal-04060048 v1
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Taking One Step Back in Familial Hypercholesterolemia

Natalia Loaiza , Merel Hartgers , Laurens Reeskamp , Jan-Willem Balder , Antoine Rimbert et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (4), pp.973-985. ⟨10.1161/ATVBAHA.119.313470⟩
Article dans une revue hal-02468286 v1
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Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids

Adriaan van Der Graaf , Annique Claringbould , Antoine Rimbert , Harm-Jan Westra , Yang Li et al.
Nature Communications, 2020, 11 (1), pp.4930. ⟨10.1038/s41467-020-18716-x⟩
Article dans une revue hal-02970789 v1
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The Future of Lipid-Lowering Therapy

Willemien Van Zwol , Antoine Rimbert , Jan Kuivenhoven
Journal of Clinical Medicine, 2019, 8 (7), pp.1085. ⟨10.3390/jcm8071085⟩
Article dans une revue hal-02422745 v1
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A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

Antoine Rimbert , Nawar Dalila , Justina Wolters , Nicolette Huijkman , Marieke Smit et al.
European Heart Journal, 2019, ⟨10.1093/eurheartj/ehz727⟩
Article dans une revue hal-02422747 v1
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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

Haojie Yu , Antoine Rimbert , Alice Palmer , Takafumi Toyohara , Yulei Xia et al.
Cell, 2019, 179 (6), pp.1276-1288.e14. ⟨10.1016/j.cell.2019.10.034⟩
Article dans une revue hal-02422749 v1

Use of plasma metabolomics to analyze phenotype-genotype relationships in young hypercholesterolemic females

Xiang Zhang , Antoine Rimbert , Willem Balder , Aeilko Having Zwinderman , Jan Albert Kuivenhoven et al.
Journal of Lipid Research, 2018, 59 (11), pp.2174-2180. ⟨10.1194/jlr.M088930⟩
Article dans une revue hal-02422741 v1

Genetics, Lifestyle, and Low-Density Lipoprotein Cholesterol in Young and Apparently Healthy Women

Jan-Willem Balder , Antoine Rimbert , Xiang Zhang , Martijn Viel , Roan Kanninga et al.
Circulation, 2018, 137 (8), pp.820-831. ⟨10.1161/CIRCULATIONAHA.117.032479⟩
Article dans une revue hal-02422740 v1
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Genetics of syndromic and non-syndromic mitral valve prolapse

Thierry Le Tourneau , Jean Merot , Antoine Rimbert , Solena Le Scouarnec , Vincent Probst et al.
Heart, 2018, 104 (12), pp.978-984. ⟨10.1136/heartjnl-2017-312420⟩
Article dans une revue hal-04754059 v1
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Identification of novel APOB mutations by targeted next-generation sequencing for the molecular diagnosis of familial hypobetalipoproteinemia

Antoine Rimbert , Matthieu Pichelin , Simon Lecointe , Marie Marrec , Solena Le Scouarnec et al.
Atherosclerosis, 2016, Equipe 3 Equipe 4 Equipe 5, 250, pp.52--56. ⟨10.1016/j.atherosclerosis.2016.04.010⟩
Article dans une revue hal-01831745 v1