Arnaud KLEIN

Chargé de Recherche - Inserm - Centre de recherche en Myologie
22
Documents
Affiliation actuelle
  • Centre de recherche en Myologie – U974 SU-INSERM
Identifiants chercheurs

Publications

Publications

Image document

The beneficial effect of chronic muscular exercise on muscle fragility is increased by Prox1 gene transfer in dystrophic mdx muscle

Alexandra Monceau , Clément Delacroix , Mégane Lemaitre , Gaelle Revet , Denis Furling et al.
PLoS ONE, 2022, 17 (4), pp.e0254274. ⟨10.1371/journal.pone.0254274⟩
Article dans une revue hal-03830867 v1

Dystrophin Restoration after Adeno-Associated Virus U7–Mediated Dmd Exon Skipping Is Modulated by Muscular Exercise in the Severe D2-Mdx Duchenne Muscular Dystrophy Murine Model

Alexandra Monceau , Dylan Moutachi , Mégane Lemaitre , Luis Garcia , Capucine Trollet et al.
American Journal of Pathology, 2022, ⟨10.1016/j.ajpath.2022.07.016⟩
Article dans une revue hal-03830848 v1
Image document

Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats

Ludovic Arandel , Magdalena Matloka , Arnaud F Klein , Frédérique Rau , Alain Sureau et al.
Nature Biomedical Engineering, 2022, 6 (2), pp.207-220. ⟨10.1038/s41551-021-00838-2⟩
Article dans une revue hal-03830811 v1
Image document

Comprehensive transcriptome-wide analysis of spliceopathy correction of myotonic dystrophy using CRISPR-Cas9 in iPSCs-derived cardiomyocytes

Sumitava Dastidar , Debanjana Majumdar , Jaitip Tipanee , Kshitiz Singh , Arnaud Klein et al.
Molecular Therapy, 2021, 29 (11), ⟨10.1016/j.ymthe.2021.08.004⟩
Article dans une revue hal-03410645 v1
Image document

Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse

Arnaud Ferry , Julien Messéant , Ara Parlakian , Mégane Lemaitre , Pauline Roy et al.
The Journal of Physiology, 2020, 598 (17), pp.3667-3689. ⟨10.1113/JP279282⟩
Article dans une revue hal-02996889 v1
Image document

Genome Editing of Expanded CTG Repeats within the Human DMPK Gene Reduces Nuclear RNA Foci in the Muscle of DM1 Mice

Mirella Lo Scrudato , Karine Poulard , Célia Sourd , Stéphanie Tomé , Arnaud Klein et al.
Molecular Therapy, 2019, Epub ahead of print. ⟨10.1016/j.ymthe.2019.05.021⟩
Article dans une revue hal-02177548 v1
Image document

Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice

Arnaud F Klein , Miguel A Varela , Ludovic Arandel , Ashling Holland , Naira Naouar et al.
Journal of Clinical Investigation, 2019, 129 (11), pp.4739 - 4744. ⟨10.1172/jci128205⟩
Article dans une revue hal-03753531 v1
Image document

Cells of Matter—In Vitro Models for Myotonic Dystrophy

Magdalena Matloka , Arnaud F Klein , Frédérique Rau , Denis Furling
Frontiers in Neurology, 2018, 9, ⟨10.3389/fneur.2018.00361⟩
Article dans une revue hal-03830776 v1
Image document

Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells

Sumitava Dastidar , Simon Ardui , Kshitiz Singh , Debanjana Majumdar , Nisha Nair et al.
Nucleic Acids Research, 2018, 46, pp.8275 - 8298. ⟨10.1093/nar/gky548⟩
Article dans une revue hal-02357315 v1

Improvement of Dystrophic Muscle Fragility by Short-Term Voluntary Exercise through Activation of Calcineurin Pathway in mdx Mice

Clement Delacroix , Janek Hyzewicz , Megane Lemaitre , Bertrand Friguet , Zhenlin Li et al.
American Journal of Pathology, 2018, 188 (11), pp.2662-2673. ⟨10.1016/j.ajpath.2018.07.015⟩
Article dans une revue hal-02134917 v1
Image document

Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds

Ludovic Arandel , Micaela Polay Espinoza , Magdalena Matloka , Audrey Bazinet , Damily de Dea Diniz et al.
Disease Models & Mechanisms, 2017, 10 (4), pp.487-497. ⟨10.1242/dmm.027367⟩
Article dans une revue hal-01519721 v1
Image document

Two novel COLVI long chains in zebrafish that are essential for muscle development

Laetitia Ramanoudjame , Claire Rocancourt , Jeanne Lainé , Arnaud Klein , Lucette Joassard et al.
Human Molecular Genetics, 2015, 24 (23), pp.6624-6639. ⟨10.1093/hmg/ddv368⟩
Article dans une revue hal-01594462 v1
Image document

New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

François-Xavier Laurent , Alain Sureau , Arnaud F Klein , François Trouslard , Erwan Gasnier et al.
Nucleic Acids Research, 2012, 40 (7), pp.3159-3171. ⟨10.1093/nar/gkr1228⟩
Article dans une revue hal-03001690 v1
Image document

Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs

Virginie François , Arnaud F Klein , Cyriaque Beley , Arnaud Jollet , Camille Lemercier et al.
Nature Structural and Molecular Biology, 2011, 18 (1), pp.85-87. ⟨10.1038/nsmb.1958⟩
Article dans une revue istex hal-03002664 v1

Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

Charlotte Fugier , Arnaud F Klein , Caroline Hammer , Stéphane Vassilopoulos , Ylva Ivarsson et al.
Nature Medicine, 2011, 17 (6), pp.720-5. ⟨10.1038/nm.2374⟩
Article dans une revue hal-00811986 v1

PABPN1 polyalanine tract deletion and long expansions modify its aggregation pattern and expression

Arnaud F Klein , Mitsuru Ebihara , Christine Alexander , Marie-Josée Dicaire , A. Marie-Josée Sasseville et al.
Experimental Cell Research, 2008, 314 (8), pp.1652-1666. ⟨10.1016/j.yexcr.2008.02.005⟩
Article dans une revue istex hal-03821688 v1

The dynamism of PABPN1 nuclear inclusions during the cell cycle

A. Marie-Josée Sasseville , Antoine W Caron , Lucie Bourget , Arnaud F Klein , Marie-Josée Dicaire et al.
Neurobiology of Disease, 2006, 23 (3), pp.621-629. ⟨10.1016/j.nbd.2006.05.015⟩
Article dans une revue istex hal-03821686 v1

PABPN1 overexpression leads to upregulation of genes encoding nuclear proteins that are sequestered in oculopharyngeal muscular dystrophy nuclear inclusions

Louis-Philippe Corbeil-Girard , Arnaud F Klein , A. Marie-Josée Sasseville , Hugo Lavoie , Anik Saint-Denis et al.
Neurobiology of Disease, 2005, 18 (3), pp.551-567. ⟨10.1016/j.nbd.2004.10.019⟩
Article dans une revue istex hal-03832516 v1

Dystrophie myotonique: de la pathophysiologie aux approaches thérapeutiques

Mário Gomes-Pereira , Arnaud F Klein
Société Française de Thérapie Cellulaire et Génique, Apr 2022, Webinar, France
Communication dans un congrès hal-04007420 v1

Myotonic dystrophy type 1: from DNA repeat expansion and toxic RNA to the development of new therapeutic approaches

Mário Gomes-Pereira , Arnaud F Klein
European reference network for rare and low prevalence complex diseases, Jul 2022, Webinar, France
Communication dans un congrès hal-04007414 v1

Decoy gene therapy to reverse RNA toxicity in DM1

Ludovic Arandel , Arnaud F Klein , Frédérique Rau , Alain Sureau , Aurélien Cordier et al.
International Myotonic Dystrophy Consortium Meeting IDMC-13, International Myotonic Dystrophy Consortium, May 2022, Osaka, Japan
Communication dans un congrès hal-03999213 v1