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Bertrand Aigle

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Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways

Li Su , Yaouba Souaibou , Laurence Hôtel , Cédric Paris , Kira J Weissman
Applied and Environmental Microbiology, 2024, pp.e0211523. ⟨10.1128/aem.02115-23⟩
Journal articles hal-04445176v2
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Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui , Alexander Brachmann
Nature Communications, 2022, 13 (1), pp.515. ⟨10.1038/s41467-022-27955-z⟩
Journal articles hal-03544763v1
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Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Virginia S Lioy , Jean-Noel Lorenzi , Soumaya Najah , Thibault Poinsignon , Herve Leh
Nature Communications, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩
Journal articles hal-03128776v2
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Towards the sustainable discovery and development of new antibiotics

Marcus Miethke , Marco Pieroni , Tilmann Weber , Mark Brönstrup , Peter Hammann
Nature Reviews Chemistry, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩
Journal articles pasteur-03427787v1
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Molecular Dynamics to Elucidate the DNA-Binding Activity of AlpZ, a Member of the Gamma-Butyrolactone Receptor Family in Streptomyces ambofaciens

Cláudia M Vicente , Jean-Michel Girardet , Laurence Hôtel , Bertrand Aigle
Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.01255⟩
Journal articles hal-02935390v1
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Accompagnement dans l’apprentissage de l’argumentation par une équipe pluridisciplinaire : quels effets sur les acteurs?

Martine Paindorge , Virginie Lang , Virginie Libante , Pascal Reboul , Bertrand Aigle
Revue internationale de pédagogie de l’enseignement supérieur, 2020, 36 (2), ⟨10.4000/ripes.2717⟩
Journal articles hal-03041936v1
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Inhibitions Dominate but Stimulations and Growth Rescues Are Not Rare Among Bacterial Isolates from Grains of Forest Soil

Milena Gonzalo , Aurélie Deveau , Bertrand Aigle
Microbial ecology, 2020, 80 (4), pp.872-884. ⟨10.1007/s00248-020-01579-6⟩
Journal articles hal-02935408v1
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N-acylation of L-amino acids in aqueous media: Evaluation of the catalytic performances of Streptomyces ambofaciens aminoacylases

Mohamed Chafik Bourkaib , Stéphane Delaunay , Xavier Framboisier , Laurence Hotel , Bertrand Aigle
Enzyme and Microbial Technology, 2020, 137, pp.109536. ⟨10.1016/j.enzmictec.2020.109536⟩
Journal articles hal-02868736v1
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Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity

Cláudia M Vicente , Annabelle Thibessard , Jean-Noël Lorenzi , Mabrouka Benhadj , Laurence Hotel
Antibiotics, 2018, 7 (4), pp.86. ⟨10.3390/antibiotics7040086⟩
Journal articles hal-01887213v1
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Diversité et activités antimicrobiennes de souches de Streptomyces de la Fetzara (Algérie)

Mabrouka Benhadj , Djamila Gacemi-Kirane , Maxime Toussaint , Laurence Hotel , Cyril Bontemps
Annales de Biologie Clinique, 2018, 76 (1), pp.81-95. ⟨10.1684/abc.2017.1316⟩
Journal articles hal-01844922v1
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Draft Whole-Genome Shotgun Sequence of Streptomyces sp. Strain ETH9427

Annabelle Thibessard , Cláudia M Vicente , Claire Bertrand , Bertrand Aigle , Pierre Leblond
Microbiology Resource Announcements, 2018, 7 (12), pp.e01197. ⟨10.1128/MRA.01197-18⟩
Journal articles hal-01887322v1

An aminoacylase activity from Streptomyces ambofaciens catalyzes the acylation of lysine on α-position and peptides on N-terminal position

Léna Dettori , Florent Ferrari , Xavier Framboisier , Cédric Paris , Yann Guiavarc’h
Engineering in Life Sciences, 2018, 18 (8), pp.589-599. ⟨10.1002/elsc.201700173⟩
Journal articles hal-01959650v1

Role of secondary metabolites in the interaction between Pseudomonas fluorescensand soil microorganisms under iron-limited conditions

Aurélie Deveau , Harald Gross , Béatrice Palin , Samina Mehnaz , Max Schnepf
FEMS Microbiology Ecology, 2016, 92 (8), pp.1-11. ⟨10.1093/femsec/fiw107⟩
Journal articles hal-01490770v1

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Mingxun Wang , Jeremy J. Carver , Vanessa V. Phelan , Laura M. Sanchez , Neha Garg
Nature Biotechnology, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩
Journal articles hal-01371824v1

Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction

Bin Wang , Jinwei Ren , Liyuan Li , Fang Fan , Guohui Pan
Chemical Communications, 2015, 51 (42), pp.8845 - 8848. ⟨10.1039/c5cc01986a⟩
Journal articles hal-01475728v1
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Minimum Information about a Biosynthetic Gene cluster.

Marnix H Medema , Renzo Kottmann , Yi Yilmaz , Matthew Cummings , John B Biggins
Nature Chemical Biology, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩
Journal articles hal-01430728v1

Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the spiramycin producer

Annabelle Thibessard , Drago Haas , Claude Gerbaud , Bertrand Aigle , Sylvie Lautru
Journal of Biotechnology, 2015, 214, pp.117-118. ⟨10.1016/j.jbiotec.2015.09.020⟩
Journal articles hal-01258341v1
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Pseudomonas fluorescens Pirates both Ferrioxamine and Ferricoelichelin Siderophores from Streptomyces ambofaciens.

Justine Galet , Aurélie Deveau , Laurence Hotel , Pascale Frey-Klett , Pierre Leblond
Applied and Environmental Microbiology, 2015, 81 (9), pp.3132-3141. ⟨10.1128/AEM.03520-14⟩
Journal articles hal-01269032v1
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Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis

Bin Wang , Fang Fan , Jinwei Ren , Guomin Ai , Bertrand Aigle
Nature Communications, 2015, 6, pp.1-5. ⟨10.1038/ncomms8674⟩
Journal articles hal-01475795v1

Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis

Lijiang Song , Luisa Laureti , Christophe Corre , Pierre Leblond , Bertrand Aigle
Journal of Antibiotics, 2014, 67 (1), pp.71 - 76. ⟨10.1038/ja.2013.119⟩
Journal articles hal-01474997v1
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A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877

Robert Bunet , Ramona Riclea , Luisa Laureti , Laurence Hotel , Cedric Paris
PLoS ONE, 2014, 9 (1), pp.e87607. ⟨10.1371/journal.pone.0087607⟩
Journal articles hal-01272916v1

Genome mining of Streptomyces ambofaciens

Bertrand Aigle , Sylvie Lautru , Dieter Spiteller , Jeroen S. Dickschat , Gregory L. Challis
Journal of Industrial Microbiology and Biotechnology, 2014, 41 (2), pp.251 - 263. ⟨10.1007/s10295-013-1379-y⟩
Journal articles hal-01475037v1

Gluconic acid-producing Pseudomonas sp. prevent γ-actinorhodin biosynthesis by Streptomyces coelicolor A3(2)

Justine Galet , Aurélie Deveau , Laurence Hotel , Pierre Leblond , Pascale Frey-Klett
Archives of Microbiology, 2014, 196 (9), pp.619-627. ⟨10.1007/s00203-014-1000-4⟩
Journal articles hal-01268576v1
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Actinomycetes: role in biotechnology and medicine

Neelu Nawani , Bertrand Aigle , Abul Mandal , Manish Bodas , Sofiane Ghorbel
BioMed Research International , 2013, 2013, ⟨10.1155/2013/687190⟩
Journal articles hal-02645473v1

Bacterial genome mining for novel natural product discovery

S. Song , L Laureti , P Gomez-Escribano , D Fox , V Yeo
Planta Medica, 2012, 78 (11), ⟨10.1055/s-0032-1320194⟩
Journal articles hal-01667347v1

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

Luisa Laureti , Lijiang Song , Sheng Huang , Christophe Corre , Pierre Leblond
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (15), pp.6258 - 6263. ⟨10.1073/pnas.1019077108⟩
Journal articles hal-02651598v1

Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins

R. Bunet , L. Song , M. Vaz Mendez , C. Corre , L. Hotel
Journal of Bacteriology, 2011, 193 ((5)), pp. 1142-1153. ⟨10.1128/JB.01269-10⟩
Journal articles hal-00606766v1
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Integrative Gene Cloning and Expression System for Streptomyces sp. US 24 and Streptomyces sp. TN 58 Bioactive Molecule Producing Strains

Samiha Sioud , Bertrand Aigle , Ines Karray-Rebai , Slim Smaoui , Samir Bejar
Journal of Biomedicine and Biotechnology, 2009, 2009 (Article ID 464986), pp.464986. ⟨10.1155/2009/464986⟩
Journal articles hal-01659292v1
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A new data mining approach for the detection of bacterial promoters combining stochastic and combinatorial methods

Catherine Eng , Charu Asthana , Bertrand Aigle , Sébastien Hergalant , Jean-Francois Mari
Journal of Computational Biology, 2009, 16 (9), pp.1211-1225. ⟨10.1089/cmb.2008.0122⟩
Journal articles inria-00419969v1
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SIGffRid: A tool to search for sigma factor binding sites in bacterial genomes using comparative approach and biologically driven statistics

Fabrice Touzain , Sophie Schbath , Isabelle Debled-Rennesson , Bertrand Aigle , Gregory Kucherov
BMC Bioinformatics, 2008, 9 (73), pp.on line. ⟨10.1186/1471-2105-9-73⟩
Journal articles inria-00580657v1
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Regulation of the Synthesis of the Angucyclinone Antibiotic Alpomycin in Streptomyces ambofaciens by the Autoregulator Receptor AlpZ and Its Specific Ligand

Robert Bunet , M. V. V Mendes , Nicolas Rouhier , Xiuhua Pang , L. Hotel
Journal of Bacteriology, 2008, 190 (9), pp.3293 - 3305. ⟨10.1128/JB.01989-07⟩
Journal articles hal-01659448v1
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Targeted Gene Disruption of the Cyclo (L-Phe, L-Pro) Biosynthetic Pathway in Streptomyces sp. US24 Strain

Samiha Sioud , Ines Karray-Rebai , Hedi Aouissaoui , Bertrand Aigle , Samir Bejar
Journal of Biomedicine and Biotechnology, 2007, 2007 (Art. No 91409), pp.1 - 9. ⟨10.1155/2007/91409⟩
Journal articles hal-01659462v1

Intraspecific variability of the terminal regions of the Streptomyces ambofaciens

F. Choulet , A. Gallois , B. Aigle , S. Mangenot , C. Gerbaud
Journal of Bacteriology, 2006, 188, p 6599-6610
Journal articles hal-00101141v1
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Intraspecific Variability of the Terminal Inverted Repeats of the Linear Chromosome of Streptomyces ambofaciens

Frédéric Choulet , Alexandre Gallois , B. Aigle , Sophie Mangenot , Claude Gerbaud
Journal of Bacteriology, 2006, 188 (18), pp.6599 - 6610. ⟨10.1128/JB.00734-06⟩
Journal articles hal-01659064v1

Evolution of the terminal regions of the streptomyces linear chromosome

Frédéric Choulet , Bertrand Aigle , Alexandre Gallois , Sophie Mangenot , Claude Gerbaud
Molecular Biology and Evolution, 2006, 23 (12), pp.2361-2369. ⟨10.1093/molbev/msl108⟩
Journal articles hal-02661267v1
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Involvement of AlpV, a New Member of the Streptomyces Antibiotic Regulatory Protein Family, in Regulation of the Duplicated Type II Polyketide Synthase alp Gene Cluster in Streptomyces ambofaciens

Bertrand Aigle , Xiuhua Pang , Bernard Decaris , Pierre Leblond
Journal of Bacteriology, 2005, 187 (7), pp.2491 - 2500. ⟨10.1128/JB.187.7.2491–2500.2005⟩
Journal articles hal-01659049v1
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Differential and Cross-Transcriptional Control of Duplicated Genes Encoding Alternative Sigma Factors in Streptomyces ambofaciens

Virginie Roth , Bertrand Aigle , Robert Bunet , Thomas Wenner , Céline Fourrier
Journal of Bacteriology, 2004, 186 (16), pp.5355 - 5365. ⟨10.1128/JB.186.16.5355–5365.2004⟩
Journal articles hal-01659043v1
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Functional Angucycline-Like Antibiotic Gene Cluster in the Terminal Inverted Repeats of the Streptomyces ambofaciens Linear Chromosome

Xiuhua Pang , Bertrand Aigle , Jean-Michel Girardet , Sophie Mangenot , Jean-Luc Pernodet
Antimicrobial Agents and Chemotherapy, 2004, 48 (2), pp.575 - 588. ⟨10.1128/AAC.48.2.575-588.2004⟩
Journal articles hal-01659031v1

End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens

Thomas Wenner , Virginie Roth , Gilles Fischer , Céline Fourrier , Bertrand Aigle
Molecular Microbiology, 2003, 50 (2), pp.411-425. ⟨10.1046/j.1365-2958.2003.03698.x⟩
Journal articles hal-01659028v1

Characterization of two Streptomyces ambofaciens recA mutants: identification of the RecA protein by immunoblotting

B. Aigle , Anne Catherine Holl , Jaime F. Angulo , Pierre Leblond , Bernard Decaris
FEMS Microbiology Letters, 1997, 149, pp.181-7. ⟨10.1111/j.1574-6968.1997.tb10326.x⟩
Journal articles hal-01658772v1

An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes

B. Aigle , Dominique Schneider , Cécile Morilhat , Dominique Vandewiele , Anne Dary
Microbiology, 1996, 142 (10), pp.2815 - 2824. ⟨10.1099/13500872-142-10-2815⟩
Journal articles hal-01659577v1

Expression of the Streptomyces coelicolor A3(2) ptpA gene encoding a phosphotyrosine protein phosphatase leads to overproduction of secondary metabolites in S. lividans

T Umeyama , Y Tanabe , Bertrand Aigle , Y Horinouchi
FEMS Microbiology Letters, 1996, 144 (2-3), pp.177-184. ⟨10.1016/0378-1097(96)00359-X⟩
Journal articles hal-03205363v1

Isolation and characterization of a mutator strain of Streptomyces ambofaciens ATCC23877 exhibiting an increased level of genetic instability

Dominique Vandewiele , Jean-Nicolas Volff , Bertrand Aigle , Jean-Marc Simonet , Bernard Decaris
Canadian Journal of Microbiology, 1996, 42 (6), pp.562 - 570. ⟨10.1139/m96-076⟩
Journal articles hal-01659581v1

Analysis of genome instability in Streptomyces ambofaciens

Dominique Schneider , Bertrand Aigle , Pierre Leblond , Jean-Marc Simonet , Bernard Decaris
Journal of general microbiology, 1993, 139 (11), pp.2559-2567. ⟨10.1099/00221287-139-11-2559⟩
Journal articles hal-01658593v1

Engineering of a polyketide synthase leads to ring-contracted stambomycins

Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui , Alexander Brachmann
VAAM workshop 2021: Biology of Bacterial Producing Natural Products, Sep 2021, Saabrucken, Germany
Conference papers hal-03666909v1

Successes, surprises and pitfalls in modular polyketide synthase engineering

Kira J. Weissman , Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui
2nd International Conference on Biomolecules and the Bioeconomy, Nov 2021, Nancy, France
Conference papers hal-03525292v1

Engineering of a polyketide synthase leads to 'low-fat' stambomycins

Li Su , Laurence Hôtel , Cédric Paris , Christophe Jacob , Bertrand Aigle
Journées francophones d'actinobactéries (ACTINO 2020), Dec 2020, On-line, France
Conference papers hal-03525244v1

Generation of analogues of stambomycins by genetic engineering and allied approaches

Li Su , Laurence Hôtel , Cédric Paris , Christophe Jacob , Bertrand Aigle
15. Congrès National de la SFM (Société Française de Microbiologie), Oct 2019, Paris, France
Conference papers hal-03666910v1

Searching For Specialized Metabolites Gene Clusters By Mining Genomic Islands: A New Comparative Genomics-Based Approach

Drago Haas , Matthieu Barba , Cláudia M Vincente , Géraldine Le Goff , Jamal Ouazzani
International Symposium on the Biology of Actinomycetes, May 2017, Jeju, South Korea
Conference papers hal-01655211v1

Mining genomic islands with Synteruptor, a new strategy for identifying secondary metabolism gene clusters

Drago Haas , Matthieu Barba , Cláudia M Vicente , Amélie Garenaux , Sárka Nezbedová
The 13th International Symposium on the Genetics of Industrial Microorganisms, Oct 2016, Wuhan, China
Conference papers hal-03042549v1

Impact of nutrient availability on the diversity, function and functioning of the forest soil bacterial communities: insights from the soil succession of the forest experimental site of Montiers.

Stephane Uroz , Marie-Pierre M.-P. Turpault , Océane Nicolitch , Yannick Colin , Marc Buée
Labex ARBRE conference, Oct 2016, Champenoux, France
Conference papers hal-03339707v1
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Pédagogie renouvelée pour des cursus d'ingénierie à l'université

Emmanuelle Jacquet , Bernard Gaume , Yves Gaillard , Eric Descourvières , Pascale Marange
Colloque sur l'Enseignement des Technologies et des Sciences de l'Information et des Systèmes, CETSIS 2014, Oct 2014, Besançon, France
Conference papers hal-01094950v1
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SIGffRid : Programme de recherche des sites de fixation des facteurs de transcription par approche comparative

Fabrice Touzain , Sophie Schbath , Isabelle Debled-Rennesson , Bertrand Aigle , Pierre Leblond
Journées Ouvertes Biologie Informatique Mathématiques - JOBIM'05, Guy Perrière, Alain Guénoche et Christophe Geourjon, Jul 2005, Lyon, France. pp.417-425
Conference papers inria-00000191v1
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Fouille de données du génome à l'aide de modèles de Markov cachés

Sébastien Hergalant , Bertrand Aigle , Pierre Leblond , Jean-François Mari
Extraction et Gestion de Connaissances - EGC 2005, Jan 2005, Paris/France, France. pp.141 -- 148
Conference papers inria-00001213v1
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Classification non supervisée par HMM de sites de fixation de facteurs de transcription chez les bactéries

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Jean-François Mari , Pierre Leblond
5èmes Journées Ouvertes : Biologie, Informatique et Mathématiques - JOBIM'04, 2004, Montréal, Canada, 1 p
Conference papers inria-00107788v1

HMM, an Efficient Way to Detect Transcriptional Promoters in Bacterial Genomes?

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Jean-François Mari , Pierre Leblond
European Conference on Computational Biology - ECCB'2003, Sep 2003, Paris, France, pp.417--419
Conference papers inria-00099570v1

Identification of transcription factor binding sites in the genome of Streptomyces coelicolor A3(2)

Patricia Lavigne , Isabelle Debled-Rennesson , Bertrand Aigle , Pierre Leblond , Gregory Kucherov
3ème Journées Post-Génomique de la DOUA 2003 - JPGD'03, 2003, Lyon, France
Conference papers inria-00099609v1

Identification of Transcription Factor Binding Sites in Streptomyces coelicolor A3(2) by Phylogenetic Comparison

Fabrice Touzain , Patricia Lavigne , Isabelle Debled-Rennesson , Bertrand Aigle , Pierre Leblond
European Conference for Computer Biology - ECCB'2003, 2003, Paris, France
Conference papers inria-00099608v1

Intragenomic reiterations detection using hidden Markov models

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Pierre Leblond , Jean-François Mari
10th International Conference on Intelligent Systems for Molecular Biology - ISMB 2002, Aug 2002, Edmonton, Canada, 1 p
Conference papers inria-00100914v1

Fouille de données à l'aide de HMM : Application à la détection de réitérations intragénomiques

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Pierre Leblond , Jean-François Mari
Journées Ouvertes Biologie Informatique Mathématiques - JOBIM'02, François Coste - Elisabeth Lebret, 2002, Saint Malo, France, pp.269-273
Conference papers inria-00100752v1

Waking up Streptomyces Secondary Metabolism by Constitutive Expression of Activators or Genetic Disruption of Repressors

Bertrand Aigle , Christophe Corre
Natural product biosynthesis by microorganisms and plants, part C, 517, Academic Press, 2012, Methods in Enzymology, ⟨10.1016/B978-0-12-404634-4.00017-6⟩
Book sections hal-02809379v1

Genome-guided Exploration of Streptomyces ambofaciens Secondary Metabolism

Bertrand Aigle , Robert Bunet , Christophe Corre , Amélie Garenaux , S. Huang
Paul J Dyson Institute of Life Sciences, School of Medicine, Swansea, UK. Streptomyces: Molecular Biology and Biotechnology, Caister Academic Press, Chapter 10 pp. 179-194, 2011, 978-1-904455-77-6
Book sections hal-01667184v1
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Fouille de données du génome à l'aide de modèles de Markov cachés

Sébastien Hergalant , Bertrand Aigle , Pierre Leblond , Jean-François Mari
Extraction et gestion des connaissances. EGC 2005, Cépaduès, 2005, Revue des Nouvelles Technologies de l'Information, 2-85428-677-4 2-85428-682-0 (vol. 1) 2-85428-683-9 (vol. 2)
Book sections hal-02832934v1