Caroline Smet-Nocca

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Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

Léa El Hajjar , Emmanuelle Boll , François-Xavier Cantrelle , Clarisse Bridot , Isabelle Landrieu et al.

Scientific Reports, 2025, 15 (9975), ⟨10.1038/s41598-025-91867-3⟩

Article dans une revue hal-05004956v1

Regulation of Glycogen Synthase Kinase-3β by Phosphorylation and O-β-Linked N-Acetylglucosaminylation: Implications on Tau Protein Phosphorylation

Léa El Hajjar , Adeline Page , Clarisse Bridot , François-Xavier Cantrelle , Isabelle Landrieu et al.

Biochemistry, 2024, 63 (12), pp.1513-1533. ⟨10.1021/acs.biochem.4c00095⟩

Article dans une revue hal-04745026v1
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Magnetic resonance investigation of conformational responses of tau protein to specific phosphorylation

Alessia Lasorsa , Hamida Merzougui , François-Xavier Cantrelle , Giuseppe Sicoli , Elian Dupré et al.

Biophysical Chemistry, 2024, Part of special issue Biophysical, Biochemical, and Cellular Events Underlying Proteinopathies Edited by Carmelo La Rosa, Danilo Milardi, Magdalena Ivanova, Andisheh Abedini, Lucie Khemtemourian, Ayyalusamy Ramamoorthy, 305 (107155), pp.107155. ⟨10.1016/j.bpc.2023.107155⟩

Article dans une revue hal-04440623v1
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Deciphering the Structure and Formation of Amyloids in Neurodegenerative Diseases With Chemical Biology Tools

Isabelle Landrieu , Elian Dupré , Davy Sinnaeve , Léa El Hajjar , Caroline Smet-Nocca

Frontiers in Chemistry, 2022, 10, pp.886382. ⟨10.3389/fchem.2022.886382⟩

Article dans une revue hal-03841022v1
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Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

François-Xavier Cantrelle , Anne Loyens , Xavier Trivelli , Oliver Reimann , Clément Despres et al.

Frontiers in Molecular Neuroscience, 2021, 14, pp.661368. ⟨10.3389/fnmol.2021.661368⟩

Article dans une revue hal-03428106v1
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Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

Pascale Barbier , Orgeta Zejneli , Marlène Martinho , Alessia Lasorsa , Valérie Belle et al.

Frontiers in Aging Neuroscience, 2019, 11, ⟨10.3389/fnagi.2019.00204⟩

Article dans une revue hal-02279660v1

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

Clément Despres , Jing Di , François-Xavier Cantrelle , Zizheng Li , Isabelle Huvent et al.

ACS Chemical Biology, 2019, 14 (6), pp.1363-1379. ⟨10.1021/acschembio.9b00325⟩

Article dans une revue hal-02317189v1

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

Michael Nshanian , Carter Lantz , Piriya Wongkongkathep , Thomas Schrader , Frank-Gerrit Klärner et al.

Journal of The American Society for Mass Spectrometry, 2019, 30 (1), pp.16-23. ⟨10.1007/s13361-018-2027-6⟩

Article dans une revue hal-02543395v1
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The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Yann Fichou , Youssra K Al-Hilaly , François Devred , Caroline Smet-Nocca , Philipp O Tsvetkov et al.

Acta Neuropathologica Communications, 2019, 7 (1), ⟨10.1186/s40478-019-0682-x⟩

Article dans une revue hal-02055894v1

The O-β-linked N-acetylglucosaminylation of the Lamin B receptor and its impact on DNA binding and phosphorylation

Caroline Smet-Nocca , Adeline Page , Francois-Xavier Cantrelle , Eleni Nikolakaki , Isabelle Landrieu et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, 2018, 1862 (4), pp.825-835. ⟨10.1016/j.bbagen.2018.01.007⟩

Article dans une revue hal-02353573v1

Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

Gwendoline Bourré , François-Xavier Cantrelle , Amina Kamah , Béatrice Chambraud , Isabelle Landrieu et al.

Frontiers in Endocrinology, 2018, 9, ⟨10.3389/fendo.2018.00595⟩

Article dans une revue hal-02337415v1
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Identification of the Tau phosphorylation pattern that drives its aggregation

Clement Despres , Cillian Byrne , Haoling Qi , François-Xavier Cantrelle , Isabelle Huvent et al.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (34), pp.9080 - 9085. ⟨10.1073/pnas.1708448114⟩

Article dans une revue hal-01620128v1

Semi-synthesis of a tag-free O -GlcNAcylated tau protein by sequential chemoselective ligation

Sergej Schwagerus , Oliver Reimann , Clement Despres , Caroline Smet-Nocca , Christian P. R. Hackenberger

Journal of Peptide Science, 2016, 22 (5), pp.327 - 333. ⟨10.1002/psc.2870⟩

Article dans une revue istex hal-01389835v1
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NMR Meets Tau: Insights into Its Function and Pathology

Guy Lippens , Isabelle Landrieu , Caroline Smet , Isabelle Huvent , Neha Gandhi et al.

Ancient biomolecules, 2016, 6 (2), ⟨10.3390/biom6020028⟩

Article dans une revue (article de synthèse) hal-01389829v1

Proline Conformation in a Functional Tau Fragment

Puneet Ahuja , Xavier Cantrelle , Isabelle Huvent , Xavier Hanoulle , Juan Lopez et al.

Journal of Molecular Biology, 2016, 428 (1), pp.79 - 91. ⟨10.1016/j.jmb.2015.11.023⟩

Article dans une revue istex hal-01389832v1

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins

Clément Danis , Clement Despres , Luiza M. Bessa , Idir Malki , Hamida Merzougui et al.

Journal of visualized experiments : JoVE, 2016, 118, ⟨10.3791/55001⟩

Article dans une revue hal-01620152v1

Isomerisation and oligomerization of truncated and mutated tau forms by FKBP52 are independent processes.

A Kamah , F X Cantrelle , I Huvent , J Giustiniani , K Guillemeau et al.

Journal of Molecular Biology, 2016, 428 (6), pp.1080-1090. ⟨10.1016/j.jmb.2016.02.015⟩

Article dans une revue hal-01278622v1

Traceless Purification and Desulfurization of Tau Protein Ligation Products

Oliver Reimann , Caroline Smet-Nocca , Christian P. R. Hackenberger

Angewandte Chemie International Edition, 2015, 54 (1), pp.306 - 310. ⟨10.1002/anie.201408674⟩

Article dans une revue istex hal-01389837v1

Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure

Emilie Dubois-Deruy , Aude Belliard , Paul Mulder , Marion Bouvet , Caroline Smet-Nocca et al.

Cardiovascular Research, 2015, 107 (1), pp.56-65. ⟨10.1093/cvr/cvv136⟩

Article dans une revue inserm-03833102v1

Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation.

Haoling Qi , François-Xavier Cantrelle , Houda Benhelli-Mokrani , Caroline Smet-Nocca , Luc Buée et al.

Biochemistry, 2015, 54 (7), pp.1525-33

Article dans une revue hal-01145987v1

A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge.

Isabelle Huvent , Amina Kamah , François-Xavier Cantrelle , Nicolas Barois , Christian Slomianny et al.

Biochemical and Biophysical Research Communications, 2014, 445 (2), pp.299-303. ⟨10.1016/j.bbrc.2014.01.161⟩

Article dans une revue istex hal-01077911v1

Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein.

Amina Kamah , Isabelle Huvent , François-Xavier Cantrelle , Haoling Qi , Guy Lippens et al.

Biochemistry, 2014, 53 (18), pp.3020-32. ⟨10.1021/bi500006v⟩

Article dans une revue hal-01077868v1

A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes

Arndt G. Benecke , Sebastian Eilebrecht , Hélène Léger , Caroline Smet-Nocca , Amel Attmane-Elakeb et al.

Genomics, Proteomics and Bioinformatics, 2014, 12 (1), pp.8-18. ⟨10.1016/j.gpb.2013.11.001⟩

Article dans une revue hal-01544142v1

50nm-Scale Localization of Single Unmodified, Isotopically Enriched, Proteins in Cells

Anthony Delaune , Armelle Cabin-Flaman , Guillaume Legent , David Gibouin , Caroline Smet-Nocca et al.

PLoS ONE, 2013, 8 (2), pp.e56559. ⟨10.1371/journal.pone.0056559⟩

Article dans une revue hal-01544145v1

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.

Kunie Ando , Pierre Dourlen , Anne-Véronique Sambo , Alexis Bretteville , Karim Bélarbi et al.

Neurobiol Aging, 2013, 34 (3), pp.757-69. ⟨10.1016/j.neurobiolaging.2012.08.004⟩

Article dans une revue istex hal-00765859v1

Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA.

Caroline Smet-Nocca , Hélène Launay , Jean-Michel Wieruszeski , Guy Lippens , Isabelle Landrieu

Journal of Biomolecular NMR, 2013, 55 (4), pp.323-37. ⟨10.1007/s10858-013-9716-z⟩

Article dans une revue istex hal-00903359v1

50nm scale localization of single unmodified, isotopically enriched, proteins in cells

Anthony Delaune , Armelle Cabin-Flaman , Guillaume Legent , David Gibouin , Caroline Smet-Nocca et al.

PLoS ONE, 2013, 8, pp.e56559

Article dans une revue hal-04441019v1

Cell signaling, post-translational protein modifications and NMR spectroscopy.

Francois-Xavier Theillet , Caroline Smet-Nocca , Stamatios Liokatis , Rossukon Thongwichian , Jonas Kosten et al.

Journal of Biomolecular NMR, 2012, 54 (3), pp.217-36. ⟨10.1007/s10858-012-9674-x⟩

Article dans une revue hal-00765863v1

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.

Peter Borghgraef , Clément Menuet , Clara Theunis , Justin V Louis , Herman Devijver et al.

PLoS ONE, 2012, pp.e84442

Article dans une revue hal-01077942v1

Molecular Basis for an Ancient Partnership between Prolyl Isomerase Pin1 and Phosphatase Inhibitor-2.

Furqan Sami , Caroline Smet-Nocca , Meera Khan , Isabelle Landrieu , Guy Lippens et al.

Biochemistry, 2011, 50 (30), pp.6567-78. ⟨10.1021/bi200553e⟩

Article dans une revue hal-00618273v1

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.

Caroline Smet-Nocca , Malgorzata Broncel , Jean-Michel Wieruszeski , Caroline Tokarski , Xavier Hanoulle et al.

Molecular BioSystems, 2011, 7 (5), pp.1420-9. ⟨10.1039/c0mb00337a⟩

Article dans une revue hal-00586849v1

Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.

Isabelle Landrieu , Caroline Smet-Nocca , Laziza Amniai , Justin Vijay Louis , Jean-Michel Wieruszeski et al.

PLoS ONE, 2011, 6 (6), pp.e21521. ⟨10.1371/journal.pone.0021521⟩

Article dans une revue hal-00618270v1

NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease.

Isabelle Landrieu , Arnaud Leroy , Caroline Smet-Nocca , Isabelle Huvent , Laziza Amniai et al.

Biochemical Society Transactions, 2010, 38 (4), pp.1006-11. ⟨10.1042/BST0381006⟩

Article dans une revue hal-00586933v1

The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins.

Hélène Hodak , Alexandre Wohlkönig , Caroline Smet-Nocca , Hervé Drobecq , Jean-Michel Wieruszeski et al.

Journal of Molecular Biology, 2008, 376 (2), pp.414-26. ⟨10.1016/j.jmb.2007.10.088⟩

Article dans une revue istex hal-00273348v1

Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy.

Guy Lippens , Alain Sillen , Caroline Smet , Jean-Michel Wieruszeski , Arnaud Leroy et al.

Protein and Peptide Letters, 2006, 13, pp.235-246

Article dans une revue hal-00085628v1

Exploring the Molecular Function of PIN1 by Nuclear Magnetic Resonance.

Isabelle Landrieu , Caroline Smet , Jean-Michel Wieruszeski , Anne-Véronique Sambo , René Wintjens et al.

Current Protein and Peptide Science, 2006, 7, pp.179-194

Article dans une revue hal-00085621v1

Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy

Léa El Hajjar , Clarisse Bridot , Marine Nguyen , François-Xavier Cantrelle , Isabelle Landrieu et al.

Tau Protein, 2754, Springer US, pp.271-306, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3629-9_15⟩

Chapitre d'ouvrage hal-04745030v1

The O-GlcNAc Modification of Recombinant Tau Protein and Characterization of the O-GlcNAc Pattern for Functional Study

Léa El Hajjar , Clarisse Bridot , Marine Nguyen , François-Xavier Cantrelle , Isabelle Landrieu et al.

Tau Protein, 2754, Springer US, pp.237-269, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3629-9_14⟩

Chapitre d'ouvrage hal-04745031v1

Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications

Clément Danis , Elian Dupré , Xavier Hanoulle , Isabelle Landrieu , Alessia Lasorsa et al.

Advanced in Experimental Medical Biology, pp.35-45, 2019, ⟨10.1007/978-981-32-9358-8_3⟩

Chapitre d'ouvrage hal-02506938v1

The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein

Haoling Qi , Clément Despres , Sudhakaran Prabakaran , Francois-Xavier Cantrelle , Béatrice Chambraud et al.

Nocca Smet, Caroline. Tau protein : methods and protocols, 1523, Springer New York, pp.179-213, 2017, 978-1-4939-6596-0. ⟨10.1007/978-1-4939-6598-4_11⟩

Chapitre d'ouvrage hal-03235823v1

Tau Protein

Caroline Smet-Nocca

Caroline Smet-Nocca. Springer US, 2754, 2024, Methods in Molecular Biology, 978-1-0716-3628-2. ⟨10.1007/978-1-0716-3629-9⟩

Ouvrages hal-05165479v1

Tau Protein

Caroline Smet-Nocca

Caroline Smet-Nocca. Springer New York, 1523, 2017, Methods in Molecular Biology, 978-1-4939-6596-0. ⟨10.1007/978-1-4939-6598-4⟩

Ouvrages hal-05165458v1