cédric lecoutey

25
Documents
Affiliations actuelles
  • Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN)
  • Université de Caen Normandie - UFR Santé (UNICAEN Santé)
Identifiants chercheurs

Publications

Publications

Targeting together cholinesterases and serotonin reuptake against Alzheimer’s disease

Thomas Guiselin , Cédric Lecoutey , Christophe Rochais , Patrick Dallemagne
Journal of Pharmacy and Pharmacology, 2025, 77 (10), pp.1303-1318. ⟨10.1093/jpp/rgaf041⟩
Article dans une revue hal-05297207 v1
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Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease

Christophe Rochais , Cédric Lecoutey , Julien Lalut , Audrey Davis , Emilie Duval et al.
European Journal of Medicinal Chemistry, 2024, 280, pp.116975. ⟨10.1016/j.ejmech.2024.116975⟩
Article dans une revue hal-04760765 v1
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Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Maxime Mistretta , Mena Cimino , Pascal Campagne , Stevenn Volant , Etienne Kornobis et al.
Nature Communications, 2024, 15 (1), pp.4175. ⟨10.1038/s41467-024-48269-2⟩
Article dans une revue hal-04578611 v1
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Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease

Thomas Guiselin , Cédric Lecoutey , Christophe Rochais , Patrick Dallemagne
Pharmaceutics, 2023, 15 (10), pp.2382. ⟨10.3390/pharmaceutics15102382⟩
Article dans une revue hal-04414828 v1
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis et al.
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
Article dans une revue hal-03082877 v1
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Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy

Cédric Lecoutey , Rémi Legay , Audrey Davis , Jana Sopková-de Oliveira Santos , Patrick Dallemagne et al.
Molecules, 2021, 26 (9), pp.2536. ⟨10.3390/molecules26092536⟩
Article dans une revue hal-03969972 v1
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Donecopride, a Swiss army knife with potential interest against Alzheimer's disease

Christophe Rochais , Cédric Lecoutey , Katia Hamidouche , Patrizia Giannoni , Florence Gaven et al.
British Journal of Pharmacology, In press, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩
Article dans une revue hal-02428730 v1
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Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)

Caroline Lanthier , Patrick Dallemagne , Cédric Lecoutey , Sylvie Claeysen , Cédric Lecoutey
Expert Opinion on Therapeutic Patents, 2020, 30 (7), pp.495-508. ⟨10.1080/13543776.2020.1767587⟩
Article dans une revue hal-02863879 v1
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Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis

Songuigama Coulibaly , Mena Cimino , Mahama Ouattara , Cédric Lecoutey , Maria V Buchieri et al.
European Journal of Medicinal Chemistry, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩
Article dans une revue pasteur-03261309 v1
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Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease

Julien Lalut , Hugo Payan , Audrey Davis , Cédric Lecoutey , Rémi Legay et al.
Scientific Reports, 2020, 10, pp.3014. ⟨10.1038/s41598-020-59805-7⟩
Article dans une revue hal-02485740 v1

Impact of T161, Y318 and S363 alanine mutations on regulation of the human delta-opioid receptor (hDOPr) induced by peptidic and alkaloid agonists

Elise Camacho , Nicolas Marie , Quentin Dupas , Caroline Martel , Marie Nowoczyn et al.
Neuropharmacology, In press, 179, ⟨10.1016/j.neuropharm.2020.108286⟩
Article dans une revue hal-03021820 v1
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A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

Bérénice Hatat , Samir Yahiaoui , Cédric Lecoutey , Audrey Davis , Thomas Freret et al.
Frontiers in Aging Neuroscience, 2019, 11, pp.148. ⟨10.3389/fnagi.2019.00148⟩
Article dans une revue hal-02399864 v1
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Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease

François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis et al.
Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Article dans une revue hal-02399906 v1

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Julien Lalut , Gianluca Santoni , Delphine Karila , Cédric Lecoutey , Audrey Davis et al.
European Journal of Medicinal Chemistry, 2019, 162, pp.234-248. ⟨10.1016/j.ejmech.2018.10.064⟩
Article dans une revue hal-01994096 v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

Caroline Lanthier , Hugo Payan , Irene Liparulo , Bérénice Hatat , Cédric Lecoutey et al.
European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩
Article dans une revue hal-02399942 v1

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

Jean-Pierre Jourdan , Marc Since , Laïla El kihel , Cédric Lecoutey , Sophie Corvaisier et al.
ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩
Article dans une revue hal-02043731 v1

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Jean-Pierre Jourdan , Marc Since , Laïla El Kihel , Cédric Lecoutey , Sophie Corvaisier et al.
European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩
Article dans une revue hal-02043765 v1

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography

Julien Lalut , Benjamin B. Tournier , Thomas Cailly , Cédric Lecoutey , Sophie Corvaisier et al.
European Journal of Medicinal Chemistry, 2016, 116, pp.90-101. ⟨10.1016/j.ejmech.2016.03.059⟩
Article dans une revue hal-02011098 v1
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Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

Cédric Lecoutey , Cédric Lecoutey , Florence Gaven , Patrizia Giannoni , Katia Hamidouche et al.
Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩
Article dans une revue hal-02043873 v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue hal-01800439 v2

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

David Genest , Christophe Rochais , Cédric Lecoutey , Jana Sopkova-de Oliveira Santos , Céline Ballandonne et al.
MedChemComm, 2013, 4, pp.925-931
Article dans une revue hal-00840942 v1

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.

Cédric Lecoutey , Christophe Rochais , David Genest , Sabrina Butt-Gueulle , Céline Ballandonne et al.
MedChemComm, 2012, 3, pp.627-634
Article dans une revue hal-00764795 v1

Efficient Room-Temperature One-Pot Synthesis of 2-Amino-3-alkyl(3-aryl)quinazolin-4(3H)-ones

Cédric Lecoutey , Christine Fossey , Sylvain Rault , Frédéric Fabis
European Journal of Organic Chemistry, 2011, 2011 (15), pp.2785-2788
Article dans une revue hal-02018181 v1