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            Targeting together cholinesterases and serotonin reuptake against Alzheimer’s disease
        
                            
                                                                                                            Thomas Guiselin
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Christophe Rochais
                                                                ,
                                                                                                                                Patrick Dallemagne
                                                                                    
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-05297207
                                            v1
                                    
            
        
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            Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease
        
                            
                                                                                                            Christophe Rochais
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Julien Lalut
                                                                ,
                                                                                                                                Audrey Davis
                                                                ,
                                                                                                                                Emilie Duval
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-04760765
                                            v1
                                    
            
        
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            Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
        
                            
                                                                                                            Maxime Mistretta
                                                                ,
                                                                                                                                Mena Cimino
                                                                ,
                                                                                                                                Pascal Campagne
                                                                ,
                                                                                                                                Stevenn Volant
                                                                ,
                                                                                                                                Etienne Kornobis
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-04578611
                                            v1
                                    
            
        
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            Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease
        
                            
                                                                                                            Thomas Guiselin
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Christophe Rochais
                                                                ,
                                                                                                                                Patrick Dallemagne
                                                                                    
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-04414828
                                            v1
                                    
            
        
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            Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease
        
                            
                                                                                                            François-Xavier Toublet
                                                                ,
                                                                                                                                Julien Lalut
                                                                ,
                                                                                                                                Bérénice Hatat
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Audrey Davis
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-03082877
                                            v1
                                    
            
        
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            Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy
        
                            
                                                                                                            Cédric Lecoutey
                                                                ,
                                                                                                                                Rémi Legay
                                                                ,
                                                                                                                                Audrey Davis
                                                                ,
                                                                                                                                Jana Sopková-de Oliveira Santos
                                                                ,
                                                                                                                                Patrick Dallemagne
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-03969972
                                            v1
                                    
            
        
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            Donecopride, a Swiss army knife with potential interest against Alzheimer's disease
        
                            
                                                                                                            Christophe Rochais
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Katia Hamidouche
                                                                ,
                                                                                                                                Patrizia Giannoni
                                                                ,
                                                                                                                                Florence Gaven
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02428730
                                            v1
                                    
            
        
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            Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)
        
                            
                                                                                                            Caroline Lanthier
                                                                ,
                                                                                                                                Patrick Dallemagne
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Sylvie Claeysen
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                                    
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02863879
                                            v1
                                    
            
        
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            Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis
        
                            
                                                                                                            Songuigama Coulibaly
                                                                ,
                                                                                                                                Mena Cimino
                                                                ,
                                                                                                                                Mahama Ouattara
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Maria V Buchieri
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    pasteur-03261309
                                            v1
                                    
            
        
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            Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease
        
                            
                                                                                                            Julien Lalut
                                                                ,
                                                                                                                                Hugo Payan
                                                                ,
                                                                                                                                Audrey Davis
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Rémi Legay
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02485740
                                            v1
                                    
            
        
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            Impact of T161, Y318 and S363 alanine mutations on regulation of the human delta-opioid receptor (hDOPr) induced by peptidic and alkaloid agonists
        
                            
                                                                                                            Elise Camacho
                                                                ,
                                                                                                                                Nicolas Marie
                                                                ,
                                                                                                                                Quentin Dupas
                                                                ,
                                                                                                                                Caroline Martel
                                                                ,
                                                                                                                                Marie Nowoczyn
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-03021820
                                            v1
                                    
            
        
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            A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease
        
                            
                                                                                                            Bérénice Hatat
                                                                ,
                                                                                                                                Samir Yahiaoui
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Audrey Davis
                                                                ,
                                                                                                                                Thomas Freret
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02399864
                                            v1
                                    
            
        
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            Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease
        
                            
                                                                                                            François-Xavier Toublet
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Julien Lalut
                                                                ,
                                                                                                                                Bérénice Hatat
                                                                ,
                                                                                                                                Audrey Davis
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02399906
                                            v1
                                    
            
        
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            Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
        
                            
                                                                                                            Julien Lalut
                                                                ,
                                                                                                                                Gianluca Santoni
                                                                ,
                                                                                                                                Delphine Karila
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Audrey Davis
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-01994096
                                            v1
                                    
            
        
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            Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease
        
                            
                                                                                                            Caroline Lanthier
                                                                ,
                                                                                                                                Hugo Payan
                                                                ,
                                                                                                                                Irene Liparulo
                                                                ,
                                                                                                                                Bérénice Hatat
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02399942
                                            v1
                                    
            
        
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            Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
        
                            
                                                                                                            Jean-Pierre Jourdan
                                                                ,
                                                                                                                                Marc Since
                                                                ,
                                                                                                                                Laïla El kihel
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Sophie Corvaisier
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02043731
                                            v1
                                    
            
        
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            Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
        
                            
                                                                                                            Jean-Pierre Jourdan
                                                                ,
                                                                                                                                Marc Since
                                                                ,
                                                                                                                                Laïla El Kihel
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Sophie Corvaisier
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02043765
                                            v1
                                    
            
        
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            Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography
        
                            
                                                                                                            Julien Lalut
                                                                ,
                                                                                                                                Benjamin B. Tournier
                                                                ,
                                                                                                                                Thomas Cailly
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Sophie Corvaisier
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02011098
                                            v1
                                    
            
        
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            Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride
        
                            
                                                                                                            Cédric Lecoutey
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Florence Gaven
                                                                ,
                                                                                                                                Patrizia Giannoni
                                                                ,
                                                                                                                                Katia Hamidouche
                                                                                            et al.
                            
                 
                            
                 Article dans une revue
                    
        
        
            
                
                    hal-02043873
                                            v1
                                    
            
        
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            Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
        
                            
                                                                                                            Cédric Lecoutey
                                                                ,
                                                                                                                                Damien Hedou
                                                                ,
                                                                                                                                Thomas Freret
                                                                ,
                                                                                                                                Patrizia Giannoni
                                                                ,
                                                                                                                                Florence Gaven
                                                                                            et al.
                            
                 
                            Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30.  ⟨10.1073/pnas.1410315111⟩ 
                 Article dans une revue
                    
        
        
            
                
                    hal-01800439
                                            v2
                                    
            
        
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            Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.
        
                            
                                                                                                            David Genest
                                                                ,
                                                                                                                                Christophe Rochais
                                                                ,
                                                                                                                                Cédric Lecoutey
                                                                ,
                                                                                                                                Jana Sopkova-de Oliveira Santos
                                                                ,
                                                                                                                                Céline Ballandonne
                                                                                            et al.
                            
                 
                            MedChemComm, 2013, 4, pp.925-931 
                 Article dans une revue
                    
        
        
            
                
                    hal-00840942
                                            v1
                                    
            
        
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            Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.
        
                            
                                                                                                            Cédric Lecoutey
                                                                ,
                                                                                                                                Christophe Rochais
                                                                ,
                                                                                                                                David Genest
                                                                ,
                                                                                                                                Sabrina Butt-Gueulle
                                                                ,
                                                                                                                                Céline Ballandonne
                                                                                            et al.
                            
                 
                            MedChemComm, 2012, 3, pp.627-634 
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                    hal-00764795
                                            v1
                                    
            
        
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            Efficient Room-Temperature One-Pot Synthesis of 2-Amino-3-alkyl(3-aryl)quinazolin-4(3H)-ones
        
                            
                                                                                                            Cédric Lecoutey
                                                                ,
                                                                                                                                Christine Fossey
                                                                ,
                                                                                                                                Sylvain Rault
                                                                ,
                                                                                                                                Frédéric Fabis
                                                                                    
                 
                            European Journal of Organic Chemistry, 2011, 2011 (15), pp.2785-2788 
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                    hal-02018181
                                            v1
                                    
            
        
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