Charlie Wilson

98%
Libre accès
66
Documents
Affiliations actuelles
  • Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (SBRI)
  • Université Claude Bernard Lyon 1 (UCBL)
Contact

Présentation

I study the neural dynamics of frontal cortical networks during adaptive behaviour and learning to learn in humans and macaques. I want to understand how the brain dynamics linked to cognition emerge during long term learning, and how those dynamics contribute to a cognitive system that is flexible and efficient. To do this we make recordings of neural activity whilst human and monkey subjects perform cognitive tasks, and in particular learn to perform those tasks more efficiently. The aim is to track the emergence of so-called executive processes, and in particular to track the neural dynamics that are necessary to put in place such processes. My recent and future work in this field has focused on cortical oscillations. Cortical oscillations subserve interaction between assemblies in the brain, and we wish to reveal how cortical oscillations build up the dynamical networks necessary to acquire and perform complex cognitive tasks.

Current projects

  1. We are studying the way in which cortical assemblies interact in order to subserve 'learning to learn', the principle of improving one's learning, becoming flexible in one's learning, and applying task sets appropriate to a given situation. We will study the very specific interactions of the midcingulate cortex and posterior parietal cortex with prefrontal cortex. This project also involves the development of pathway specific DREADD interventions, to reveal the causal influence of the interaction mechanisms revealed by the neurophysiological recordings. Finally the project will also see the development of free-access testing and recording in macaques, a significant refinement in this work. The project is funded by the French ANR.

  2. In collaboration with Véronique Sgambato of the Institut des Sciences Cognitives Marc Jeannerod also in Lyon, we are further developing the pathway specific DREADD interventions to target striato-cortical pathways implicated in impulsivity. As part of this project we will use PET scanning to provide detailed pharmacological analysis of novel and prospective DREADD actuators, specifically within the dopaminergic and serotoninergic systems. This project is funded by Fondation Neurodis.

  3. We are studying the bursting properties of frontal and parietal cortical oscillations, in the context of tasks requiring animals to explore and exploit their environment, and to decide when to switch between the two behaviours.

  4. We seek to understand how oscillations and other neurophysiological markers change during the early stages of Parkinson's disease prior to the development of the classical symptoms of the disease. This project has clear clinical benefits in terms of understanding early neuro-degeneration, but also brings fundamental knowledge about the assemblies of the frontal cortex and their relation to dopamine.


Compétences

Behavioural Neuroscience Electrophysiology Cognitive training Neurosurgery Anaesthesia PET MRI Neurophysiological recording Neural analysis ECoG EEG

Publications

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Publications

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Simulations reveal that beta burst detection may inappropriately characterize the beta band

Zachary Langford , Charles Wilson
Journal of Neurophysiology, 2025, ⟨10.1152/jn.00125.2024⟩
Article dans une revue hal-05125810 v1

Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human

Camille Giacometti , Delphine Autran-Clavagnier , Audrey Dureux , Laura Viñales , Franck Lamberton et al.
Communications Biology, 2024, 7 (1), pp.269. ⟨10.1038/s42003-024-05918-y⟩
Article dans une revue hal-04749607 v1
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Medial to lateral frontal functional connectivity mapping reveals the organization of cingulate cortex

Marion Ducret , Camille Giacometti , Manon Dirheimer , Audrey Dureux , Delphine Autran-Clavagnier et al.
Cerebral Cortex, 2024, 34 (8), pp.bhae322. ⟨10.1093/cercor/bhae322⟩
Article dans une revue hal-04671739 v1
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The relevance of the unique anatomy of the human prefrontal operculum to the emergence of speech

Céline Amiez , Charles Verstraete , Jérôme Sallet , Fadila Hadj-Bouziane , Suliann Ben Hamed et al.
Communications Biology, 2023, 6 (1), pp.693. ⟨10.1038/s42003-023-05066-9⟩
Article dans une revue hal-04237943 v1
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A revised perspective on the evolution of the lateral frontal cortex in primates

Céline Amiez , Jérôme Sallet , Camille Giacometti , Charles Verstraete , Clémence Gandaux et al.
Science Advances , 2023, 9 (20), pp.eadf9445. ⟨10.1126/sciadv.adf9445⟩
Article dans une revue hal-04237941 v1

Frontal effective connectivity increases with task demands and time on task: a Dynamic Causal Model of electrocorticogram in macaque monkeys

Katharina Wegner , Charles Wilson , Emmanuel Procyk , Karl Friston , Frederik van de Steen et al.
Neurons, Behavior, Data analysis, and Theory, 2023, 6 (1), ⟨10.51628/001c.68433⟩
Article dans une revue hal-04749640 v1
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A response to claims of emergent intelligence and sentience in a dish

Fuat Balci , Suliann Ben Hamed , Thomas Boraud , Sébastien Bouret , Thomas Brochier et al.
Neuron, 2023, 111 (5), pp.604-605. ⟨10.1016/j.neuron.2023.02.009⟩
Article dans une revue (compte-rendu de lecture) hal-04012408 v1

Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging

Michael Milham , Chris Petkov , Pascal Belin , Suliann Ben Hamed , Henry Evrard et al.
Neuron, 2022, 110 (1), pp.16-20. ⟨10.1016/j.neuron.2021.10.015⟩
Article dans une revue hal-03800370 v1
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Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: a Longitudinal Study in a Macaque Model of Parkinson’s Disease

Florence Wianny , Kwamivi Dzahini , Karim Fifel , Charles R.E. Wilson , Agnieszka Bernat et al.
Advanced Science, 2022, 9 (10), pp.2103827. ⟨10.1002/advs.202103827⟩
Article dans une revue hal-03436232 v2
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Frontal cortical functional connectivity is impacted by anaesthesia in macaques

Camille Giacometti , Audrey Dureux , Delphine Autran-Clavagnier , Charles Wilson , Jérôme Sallet et al.
Cerebral Cortex, 2022, 32 (18), pp.4050-4067. ⟨10.1093/cercor/bhab465⟩
Article dans une revue hal-03811064 v1
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Formalising planning and information search in naturalistic decision-making

Hunt Lt , N. Daw , P. Kaanders , M A Maclaver , U. Mugan et al.
Nature Neuroscience, 2021, 24 (8), pp.1051-1064. ⟨10.1038/s41593-021-00866-w⟩
Article dans une revue inserm-03354461 v1
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The midcingulate cortex and temporal integration

Emmanuel Procyk , Vincent Fontanier , Matthieu Sarazin , Bruno Delord , Clément Goussi et al.
International Review of Neurobiology, 2021, What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, 158, pp.395 - 419. ⟨10.1016/bs.irn.2020.12.004⟩
Article dans une revue hal-03755027 v1
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Imaging evolution of the primate brain: the next frontier?

Patrick Friedrich , Stephanie Forkel , Céline Amiez , Joshua H Balsters , Olivier A Coulon et al.
NeuroImage, 2021, 228, pp.117685. ⟨10.1016/j.neuroimage.2020.117685⟩
Article dans une revue hal-03167237 v1
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Accelerating the Evolution of Nonhuman Primate Neuroimaging

Michael Milham , Christopher I Petkov , Daniel Margulies , Charles E Schroeder , Michele A Basso et al.
Neuron, 2020, 105 (4), pp.600 - 603. ⟨10.1016/j.neuron.2019.12.023⟩
Article dans une revue hal-02993101 v1
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Sulcal organization in the medial frontal cortex provides insights into primate brain evolution

Céline Amiez , Jerome Sallet , William D. Hopkins , Adrien Meguerditchian , Fadila Hadj-Bouziane et al.
Nature Communications, 2019, 10 (1), pp.3437. ⟨10.1038/s41467-019-11347-x⟩
Article dans une revue hal-02326265 v1
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An Open Resource for Non-human Primate Imaging

Michael Milham , Lei Ai , Bonhwang Koo , Ting Xu , Céline Amiez et al.
Neuron, 2018, 100 (1), pp.61-74.e2. ⟨10.1016/j.neuron.2018.08.039⟩
Article dans une revue hal-02326351 v1
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Variations of cingulate sulcal organization and link with cognitive performance

Céline Amiez , Charles R E Wilson , Emmanuel Procyk
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-32088-9⟩
Article dans une revue hal-02324077 v1
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The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning

Sean Froudist-Walsh , Philip G.F. Browning , Paula L Croxson , Kathy L Murphy , Jul Lea Shamy et al.
Journal of Neuroscience, 2018, 38 (36), pp.7800-7808. ⟨10.1523/JNEUROSCI.0832-18.2018⟩
Article dans une revue hal-04802044 v1
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Midcingulate Motor Map and Feedback Detection: Converging Data from Humans and Monkeys

Emmanuel Procyk , Charles R E Wilson , Frederic M Stoll , Maïlys C M Faraut , Michael Petrides et al.
Cerebral Cortex, 2016, 26 (2), pp.467-76. ⟨10.1093/cercor/bhu213⟩
Article dans une revue hal-02358077 v1
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Learning to learn about uncertain feedback

Maïlys C.M. Faraut , Emmanuel Procyk , Charles R.E. Wilson
Perceptual and Motor Skills, 2016, 23 (2), pp.90-98. ⟨10.1101/lm.039768.115⟩
Article dans une revue hal-04802053 v1
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Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion

Charles R E Wilson , Julien Vezoli , Frederic M Stoll , Maïlys C M Faraut , Vincent Leviel et al.
PLoS Biology, 2016, 14 (11), pp.e1002576. ⟨10.1371/journal.pbio.1002576⟩
Article dans une revue inserm-02136898 v1

The Effects of Cognitive Control and Time on Frontal Beta Oscillations

Frederic M Stoll , Charles R.E. Wilson , Maïlys C.M. Faraut , Julien Vezoli , Kenneth Knoblauch et al.
Cerebral Cortex, 2016, 26 (4), pp.1715-1732. ⟨10.1093/cercor/bhv006⟩
Article dans une revue hal-02358071 v1
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A unilateral medial frontal cortical lesion impairs trial and error learning without visual control

Céline Amiez , Anne Sophie Champod , Charles R.E. Wilson , Emmanuel Procyk , Michael Petrides
Neuropsychologia, 2015, 75, pp.314-321. ⟨10.1016/j.neuropsychologia.2015.06.022⟩
Article dans une revue hal-04819104 v1
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Increased DAT binding in the early stage of the dopaminergic lesion: A longitudinal [11C]PE2I binding study in the MPTP-monkey

Julien Vezoli , Kwamivi Dzahini , Nicolas Costes , Charles R.E. Wilson , Karim Fifel et al.
NeuroImage, 2014, 102, pp.249-261. ⟨10.1016/j.neuroimage.2014.07.059⟩
Article dans une revue hal-04804860 v1
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Causal effect of disconnection lesions on interhemispheric functional connectivity in rhesus monkeys

Jill X O’reilly , Paula L Croxson , Saad Jbabdi , Jerome Sallet , Maryann P Noonan et al.
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (34), pp.13982-13987. ⟨10.1073/pnas.1305062110⟩
Article dans une revue hal-04804850 v1
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Functional localization within the prefrontal cortex: missing the forest for the trees?

Charles R.E. Wilson , David Gaffan , Philip G.F. Browning , Mark G Baxter
Trends in Neurosciences, 2010, 33 (12), pp.533-540. ⟨10.1016/j.tins.2010.08.001⟩
Article dans une revue hal-04804828 v1
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Degraded transfer of memories between the visual hemifields in normal macaques revealed by a novel infrared eyetracking method without head fixation

Charles R.E. Wilson , Mark J Buckley , David Gaffan
Neuropsychologia, 2010, 48 (5), pp.1376-1384. ⟨10.1016/j.neuropsychologia.2010.01.003⟩
Article dans une revue hal-04819067 v1
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Dissociable Roles for Cortical and Subcortical Structures in Memory Retrieval and Acquisition

Anna S Mitchell , Philip G F Browning , Charles R E Wilson , Mark G Baxter , David Gaffan
Journal of Neuroscience, 2008, 28 (34), pp.8387-8396. ⟨10.1523/JNEUROSCI.1924-08.2008⟩
Article dans une revue hal-04804994 v1
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Prefrontal–Inferotemporal Interaction Is Not Always Necessary for Reversal Learning

Charles R E Wilson , David Gaffan
Journal of Neuroscience, 2008, 28 (21), pp.5529-5538. ⟨10.1523/JNEUROSCI.0952-08.2008⟩
Article dans une revue hal-04805000 v1
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Fornix transection impairs visuospatial memory acquisition more than retrieval.

Mark J Buckley , Charles R E Wilson , David Gaffan
Behavioral Neuroscience, 2008, 122 (1), pp.44-53. ⟨10.1037/0735-7044.122.1.44⟩
Article dans une revue hal-04818966 v1
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Addition of fornix transection to frontal‐temporal disconnection increases the impairment in object‐in‐place memory in macaque monkeys

C R E Wilson , M G Baxter , A. Easton , D. Gaffan
European Journal of Neuroscience, 2008, 27 (7), pp.1814-1822. ⟨10.1111/j.1460-9568.2008.06140.x⟩
Article dans une revue hal-04805013 v1
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Medial temporal and prefrontal function: Recent behavioural disconnection studies in the macaque monkey

David Gaffan , Charles R E Wilson
Cortex, 2008, 44 (8), pp.928-935. ⟨10.1016/j.cortex.2008.03.005⟩
Article dans une revue hal-04818436 v1
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Neurotoxic lesions of ventrolateral prefrontal cortex impair object‐in‐place scene memory

Charles R E Wilson , David Gaffan , Anna S Mitchell , Mark G Baxter
European Journal of Neuroscience, 2007, 25 (8), pp.2514-2522. ⟨10.1111/j.1460-9568.2007.05468.x⟩
Article dans une revue hal-04805033 v1
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Fornix Transection Impairs Learning of Randomly Changing Object Discriminations

Charles R E Wilson , David P Charles , Mark J Buckley , David Gaffan
Journal of Neuroscience, 2007, 27 (47), pp.12868-12873. ⟨10.1523/JNEUROSCI.3536-07.2007⟩
Article dans une revue hal-04805044 v1
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Network-specific chemogenetic modulation of noradrenergic input to cingulate cortex in macaque

C Gandaux , J Sallet , M Ducret , C Goussi-Denjean , P Misery et al.
Symposium on the Biology of Decision Making SBDM 2025, Jun 2025, Lyon, France
Poster de conférence hal-05136191 v1
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MCC-DLPFC network modulation by pathway-specific DREADDs in macaque monkeys: behavioral, resting-state fMRI and histological validation

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Céline Amiez , Delphine Autran-Clavagnier et al.
FENS 2024, Jul 2024, Vienna, Austria
Poster de conférence hal-04971286 v1
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Frontal network modulations by pathway-selective chemogenetics modify behaviour of monkeys in a spatial foraging task

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Marion Ducret , Valentine Morel-Latour et al.
Foraging Meeting 2024, Dec 2024, Lyon, France
Poster de conférence hal-04971315 v1
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The neurophysiological basis of learning to learn in macaque monkeys

Marion Ducret , Emmanuel Procyk , Charles R E Wilson
FENS 2024, Jun 2024, Vienna, Austria
Poster de conférence hal-04969210 v1
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Transcranial ultrasound neuromodulation induces metabolic and resting-state changes in amygdala

J Claron , C Giacometti , S Manickam , V Morel-Latour , C R E Wilson et al.
FENS 2024, Jul 2024, Vienna, Austria
Poster de conférence hal-05136208 v1
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The neurophysiological basis of learning to learn in macaque monkeys

Marion Ducret , Emmanuel Procyk , Charles R E Wilson
Motivation and Cognitive Control, Oct 2023, Lyon, France
Poster de conférence hal-04969235 v1
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The neurophysiological basis of learning in naive macaque monkeys

Marion Ducret , Emmanuel Procyk , Charles R E Wilson
NeuroFrance 2023, May 2023, Lyon, France
Poster de conférence hal-04969300 v1
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Environment reward structure shapes exploration and strategy in humans and non-human primates

Mojtaba Alavi , Charles R E Wilson , Emmanuel Procyk , S. Ben Hamed
NeuroFrance 2023, May 2023, Lyon, France
Poster de conférence hal-04969348 v1
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Frontal beta burst properties are an index of motivation and apathy in a macaque model; of Parkinson’s disease

Charles R E Wilson , Agathe Godet , Zachary D Langford , Emmanuel Procyk
Motivation and Cognitive Control, Oct 2023, Lyon, France
Poster de conférence hal-04969229 v1
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Learning to learn about feedback, and about uncertain feedback

Charles R E Wilson , Marion Ducret , Maïlys C.M. Faraut , Emmanuel Procyk
FENS Brain Conference: Structuring Knowledge for Flexible Behaviour, Oct 2023, Rungstedgaard, Denmark
Poster de conférence hal-04969220 v1
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Description of foraging behavior in a naturalistic search task in macaque monkey: Behavioural description and LC/NA-MCC network modulation with pathway-specific chemogenetic

Clémence Gandaux , Charles R E Wilson , Marion Ducret , Valentine Morel-Latour , Pierre Misery et al.
Motivation and Cognitive Control, Oct 2023, Lyon, France
Poster de conférence hal-04969286 v1
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What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson
NeuroFrance 2023, May 2023, Lyon, France
Poster de conférence hal-04969297 v1
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Network modulation by pathway specific chemogenetics in frontal cortex of macaque monkey

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Céline Amiez , Delphine Autran-Clavagnier et al.
NeuroFrance 2023, Jun 2023, Lyon, France
Poster de conférence hal-04971306 v1
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MCC-DLPFC network modulation by pathway-specific DREADDs in macaque monkeys: behavioral, restingstate fMRI and histological validation

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Céline Amiez , Delphine Autran-Clavagnier et al.
ViMaMo 2022, Oct 2022, Paris, France
Poster de conférence hal-04969408 v1
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Beta oscillations and its role in cognitive control

Marion Ducret , Charles R E Wilson
GDR NeuralNet 2022, Sep 2022, Lyon, France
Poster de conférence hal-04969394 v1
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What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson
GDR Neural Net 2022, Sep 2022, Lyon, France
Poster de conférence hal-04969389 v1
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What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson
FENS 2022, Jul 2022, Paris, France
Poster de conférence hal-04969398 v1
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What is a burst? How to systematically detect single trial oscillatory dynamics.

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson
Symposium on Biology of Decision Making, May 2021, Paris, France
Poster de conférence hal-04970802 v1
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Development of pathway specific DREADDs in macaque monkeys: behavioral and histological studies

Clémence Gandaux , Delphine Autran-Clavagnier , Clément Goussi , Marina Lavigne , Eric Kremer et al.
NeuroFrance 2021, May 2021, Paris, France
Poster de conférence hal-04970773 v1
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Meta-learning, cognitive control, and physiological interactions between medial and lateral prefrontal cortex

Mehdi Khamassi , Charles R E Wilson , Marie Rothé , René Quilodran , Peter F Dominey et al.
Mars, R., Sallet, J., Rushworth, M. and Yeung, N. (Eds.), Neural Bases of Motivational and Cognitive Control, MIT Press, 2011
Chapitre d'ouvrage hal-03415847 v1