Charlie Wilson

98 %
Libre accès
70
Documents
Affiliations actuelles
  • Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (SBRI)
  • Université Claude Bernard Lyon 1 (UCBL)
Contact

Présentation

I study the neural dynamics of frontal cortical networks during adaptive behaviour and learning to learn in humans and macaques. I want to understand how the brain dynamics linked to cognition emerge during long term learning, and how those dynamics contribute to a cognitive system that is flexible and efficient. To do this we make recordings of neural activity whilst human and monkey subjects perform cognitive tasks, and in particular learn to perform those tasks more efficiently. The aim is to track the emergence of so-called executive processes, and in particular to track the neural dynamics that are necessary to put in place such processes. My recent and future work in this field has focused on cortical oscillations. Cortical oscillations subserve interaction between assemblies in the brain, and we wish to reveal how cortical oscillations build up the dynamical networks necessary to acquire and perform complex cognitive tasks.

Current projects

  1. We are studying the way in which cortical assemblies interact in order to subserve 'learning to learn', the principle of improving one's learning, becoming flexible in one's learning, and applying task sets appropriate to a given situation. We will study the very specific interactions of the midcingulate cortex and posterior parietal cortex with prefrontal cortex. This project also involves the development of pathway specific DREADD interventions, to reveal the causal influence of the interaction mechanisms revealed by the neurophysiological recordings. Finally the project will also see the development of free-access testing and recording in macaques, a significant refinement in this work. The project is funded by the French ANR.

  2. In collaboration with Véronique Sgambato of the Institut des Sciences Cognitives Marc Jeannerod also in Lyon, we are further developing the pathway specific DREADD interventions to target striato-cortical pathways implicated in impulsivity. As part of this project we will use PET scanning to provide detailed pharmacological analysis of novel and prospective DREADD actuators, specifically within the dopaminergic and serotoninergic systems. This project is funded by Fondation Neurodis.

  3. We are studying the bursting properties of frontal and parietal cortical oscillations, in the context of tasks requiring animals to explore and exploit their environment, and to decide when to switch between the two behaviours.

  4. We seek to understand how oscillations and other neurophysiological markers change during the early stages of Parkinson's disease prior to the development of the classical symptoms of the disease. This project has clear clinical benefits in terms of understanding early neuro-degeneration, but also brings fundamental knowledge about the assemblies of the frontal cortex and their relation to dopamine.


Compétences

Behavioural Neuroscience Electrophysiology Cognitive training Neurosurgery Anaesthesia PET MRI Neurophysiological recording Neural analysis ECoG EEG

Publications

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Publications

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The prefrontal operculum, a human-specific hub for the cognitive control of speech

Charles Verstraete , Elsa Lazzaro , Delphine Autran-Clavagnier , Manon Dirheimer , Fadila Hadj-Bouziane et al.

Communications Biology, 2025, 8, pp.1731. ⟨10.1038/s42003-025-09110-8⟩

Article dans une revue hal-05393101v1
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Motivational control is implemented by a cingulo-prefrontal network

Clémence Gandaux , Jérôme Sallet , Céline Amiez , Delphine Autran-Clavagnier , Valentine Morel-Latour et al.

Current Biology, 2025, ⟨10.1016/j.cub.2025.10.003⟩

Article dans une revue hal-05360035v1
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Simulations reveal that beta burst detection may inappropriately characterize the beta band

Zachary Langford , Charles Wilson

Journal of Neurophysiology, 2025, ⟨10.1152/jn.00125.2024⟩

Article dans une revue hal-05125810v1

Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human

Camille Giacometti , Delphine Autran-Clavagnier , Audrey Dureux , Laura Viñales , Franck Lamberton et al.

Communications Biology, 2024, 7 (1), pp.269. ⟨10.1038/s42003-024-05918-y⟩

Article dans une revue hal-04749607v1
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Medial to lateral frontal functional connectivity mapping reveals the organization of cingulate cortex

Marion Ducret , Camille Giacometti , Manon Dirheimer , Audrey Dureux , Delphine Autran-Clavagnier et al.

Cerebral Cortex, 2024, 34 (8), pp.bhae322. ⟨10.1093/cercor/bhae322⟩

Article dans une revue hal-04671739v1
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The relevance of the unique anatomy of the human prefrontal operculum to the emergence of speech

Céline Amiez , Charles Verstraete , Jérôme Sallet , Fadila Hadj-Bouziane , Suliann Ben Hamed et al.

Communications Biology, 2023, 6 (1), pp.693. ⟨10.1038/s42003-023-05066-9⟩

Article dans une revue hal-04237943v1
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A revised perspective on the evolution of the lateral frontal cortex in primates

Céline Amiez , Jérôme Sallet , Camille Giacometti , Charles Verstraete , Clémence Gandaux et al.

Science Advances , 2023, 9 (20), pp.eadf9445. ⟨10.1126/sciadv.adf9445⟩

Article dans une revue hal-04237941v1

Frontal effective connectivity increases with task demands and time on task: a Dynamic Causal Model of electrocorticogram in macaque monkeys

Katharina Wegner , Charles Wilson , Emmanuel Procyk , Karl Friston , Frederik van de Steen et al.

Neurons, Behavior, Data analysis, and Theory, 2023, 6 (1), ⟨10.51628/001c.68433⟩

Article dans une revue hal-04749640v1
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A response to claims of emergent intelligence and sentience in a dish

Fuat Balci , Suliann Ben Hamed , Thomas Boraud , Sébastien Bouret , Thomas Brochier et al.

Neuron, 2023, 111 (5), pp.604-605. ⟨10.1016/j.neuron.2023.02.009⟩

Article dans une revue (compte-rendu de lecture) hal-04012408v1

Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging

Michael Milham , Chris Petkov , Pascal Belin , Suliann Ben Hamed , Henry Evrard et al.

Neuron, 2022, 110 (1), pp.16-20. ⟨10.1016/j.neuron.2021.10.015⟩

Article dans une revue hal-03800370v1
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Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: a Longitudinal Study in a Macaque Model of Parkinson’s Disease

Florence Wianny , Kwamivi Dzahini , Karim Fifel , Charles R.E. Wilson , Agnieszka Bernat et al.

Advanced Science, 2022, 9 (10), pp.2103827. ⟨10.1002/advs.202103827⟩

Article dans une revue hal-03436232v2
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Frontal cortical functional connectivity is impacted by anaesthesia in macaques

Camille Giacometti , Audrey Dureux , Delphine Autran-Clavagnier , Charles Wilson , Jérôme Sallet et al.

Cerebral Cortex, 2022, 32 (18), pp.4050-4067. ⟨10.1093/cercor/bhab465⟩

Article dans une revue hal-03811064v1
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Formalising planning and information search in naturalistic decision-making

Hunt Lt , N. Daw , P. Kaanders , M A Maclaver , U. Mugan et al.

Nature Neuroscience, 2021, 24 (8), pp.1051-1064. ⟨10.1038/s41593-021-00866-w⟩

Article dans une revue inserm-03354461v1
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The midcingulate cortex and temporal integration

Emmanuel Procyk , Vincent Fontanier , Matthieu Sarazin , Bruno Delord , Clément Goussi et al.

International Review of Neurobiology, 2021, What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, 158, pp.395 - 419. ⟨10.1016/bs.irn.2020.12.004⟩

Article dans une revue hal-03755027v1
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Imaging evolution of the primate brain: the next frontier?

Patrick Friedrich , Stephanie Forkel , Céline Amiez , Joshua H Balsters , Olivier A Coulon et al.

NeuroImage, 2021, 228, pp.117685. ⟨10.1016/j.neuroimage.2020.117685⟩

Article dans une revue hal-03167237v1
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Accelerating the Evolution of Nonhuman Primate Neuroimaging

Michael Milham , Christopher I Petkov , Daniel Margulies , Charles E Schroeder , Michele A Basso et al.

Neuron, 2020, 105 (4), pp.600 - 603. ⟨10.1016/j.neuron.2019.12.023⟩

Article dans une revue hal-02993101v1
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Sulcal organization in the medial frontal cortex provides insights into primate brain evolution

Céline Amiez , Jerome Sallet , William D. Hopkins , Adrien Meguerditchian , Fadila Hadj-Bouziane et al.

Nature Communications, 2019, 10 (1), pp.3437. ⟨10.1038/s41467-019-11347-x⟩

Article dans une revue hal-02326265v1
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An Open Resource for Non-human Primate Imaging

Michael Milham , Lei Ai , Bonhwang Koo , Ting Xu , Céline Amiez et al.

Neuron, 2018, 100 (1), pp.61-74.e2. ⟨10.1016/j.neuron.2018.08.039⟩

Article dans une revue hal-02326351v1
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Variations of cingulate sulcal organization and link with cognitive performance

Céline Amiez , Charles R E Wilson , Emmanuel Procyk

Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-32088-9⟩

Article dans une revue hal-02324077v1
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The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning

Sean Froudist-Walsh , Philip G.F. Browning , Paula L Croxson , Kathy L Murphy , Jul Lea Shamy et al.

Journal of Neuroscience, 2018, 38 (36), pp.7800-7808. ⟨10.1523/JNEUROSCI.0832-18.2018⟩

Article dans une revue hal-04802044v1
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Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion

Charles R E Wilson , Julien Vezoli , Frederic M Stoll , Maïlys C M Faraut , Vincent Leviel et al.

PLoS Biology, 2016, 14 (11), pp.e1002576. ⟨10.1371/journal.pbio.1002576⟩

Article dans une revue inserm-02136898v1
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Learning to learn about uncertain feedback

Maïlys C.M. Faraut , Emmanuel Procyk , Charles R.E. Wilson

Perceptual and Motor Skills, 2016, 23 (2), pp.90-98. ⟨10.1101/lm.039768.115⟩

Article dans une revue hal-04802053v1
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Midcingulate Motor Map and Feedback Detection: Converging Data from Humans and Monkeys

Emmanuel Procyk , Charles R E Wilson , Frederic M Stoll , Maïlys C M Faraut , Michael Petrides et al.

Cerebral Cortex, 2016, 26 (2), pp.467-76. ⟨10.1093/cercor/bhu213⟩

Article dans une revue hal-02358077v1

The Effects of Cognitive Control and Time on Frontal Beta Oscillations

Frederic M Stoll , Charles R.E. Wilson , Maïlys C.M. Faraut , Julien Vezoli , Kenneth Knoblauch et al.

Cerebral Cortex, 2016, 26 (4), pp.1715-1732. ⟨10.1093/cercor/bhv006⟩

Article dans une revue hal-02358071v1
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A unilateral medial frontal cortical lesion impairs trial and error learning without visual control

Céline Amiez , Anne Sophie Champod , Charles R.E. Wilson , Emmanuel Procyk , Michael Petrides

Neuropsychologia, 2015, 75, pp.314-321. ⟨10.1016/j.neuropsychologia.2015.06.022⟩

Article dans une revue hal-04819104v1
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Increased DAT binding in the early stage of the dopaminergic lesion: A longitudinal [11C]PE2I binding study in the MPTP-monkey

Julien Vezoli , Kwamivi Dzahini , Nicolas Costes , Charles R.E. Wilson , Karim Fifel et al.

NeuroImage, 2014, 102, pp.249-261. ⟨10.1016/j.neuroimage.2014.07.059⟩

Article dans une revue hal-04804860v1
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Causal effect of disconnection lesions on interhemispheric functional connectivity in rhesus monkeys

Jill X O’reilly , Paula L Croxson , Saad Jbabdi , Jerome Sallet , Maryann P Noonan et al.

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (34), pp.13982-13987. ⟨10.1073/pnas.1305062110⟩

Article dans une revue hal-04804850v1
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Functional localization within the prefrontal cortex: missing the forest for the trees?

Charles R.E. Wilson , David Gaffan , Philip G.F. Browning , Mark G Baxter

Trends in Neurosciences, 2010, 33 (12), pp.533-540. ⟨10.1016/j.tins.2010.08.001⟩

Article dans une revue hal-04804828v1
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Degraded transfer of memories between the visual hemifields in normal macaques revealed by a novel infrared eyetracking method without head fixation

Charles R.E. Wilson , Mark J Buckley , David Gaffan

Neuropsychologia, 2010, 48 (5), pp.1376-1384. ⟨10.1016/j.neuropsychologia.2010.01.003⟩

Article dans une revue hal-04819067v1
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Prefrontal–Inferotemporal Interaction Is Not Always Necessary for Reversal Learning

Charles R E Wilson , David Gaffan

Journal of Neuroscience, 2008, 28 (21), pp.5529-5538. ⟨10.1523/JNEUROSCI.0952-08.2008⟩

Article dans une revue hal-04805000v1
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Dissociable Roles for Cortical and Subcortical Structures in Memory Retrieval and Acquisition

Anna S Mitchell , Philip G F Browning , Charles R E Wilson , Mark G Baxter , David Gaffan

Journal of Neuroscience, 2008, 28 (34), pp.8387-8396. ⟨10.1523/JNEUROSCI.1924-08.2008⟩

Article dans une revue hal-04804994v1
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Fornix transection impairs visuospatial memory acquisition more than retrieval.

Mark J Buckley , Charles R E Wilson , David Gaffan

Behavioral Neuroscience, 2008, 122 (1), pp.44-53. ⟨10.1037/0735-7044.122.1.44⟩

Article dans une revue hal-04818966v1
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Addition of fornix transection to frontal‐temporal disconnection increases the impairment in object‐in‐place memory in macaque monkeys

C R E Wilson , M G Baxter , A. Easton , D. Gaffan

European Journal of Neuroscience, 2008, 27 (7), pp.1814-1822. ⟨10.1111/j.1460-9568.2008.06140.x⟩

Article dans une revue hal-04805013v1
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Medial temporal and prefrontal function: Recent behavioural disconnection studies in the macaque monkey

David Gaffan , Charles R E Wilson

Cortex, 2008, 44 (8), pp.928-935. ⟨10.1016/j.cortex.2008.03.005⟩

Article dans une revue hal-04818436v1
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Neurotoxic lesions of ventrolateral prefrontal cortex impair object‐in‐place scene memory

Charles R E Wilson , David Gaffan , Anna S Mitchell , Mark G Baxter

European Journal of Neuroscience, 2007, 25 (8), pp.2514-2522. ⟨10.1111/j.1460-9568.2007.05468.x⟩

Article dans une revue hal-04805033v1
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Fornix Transection Impairs Learning of Randomly Changing Object Discriminations

Charles R E Wilson , David P Charles , Mark J Buckley , David Gaffan

Journal of Neuroscience, 2007, 27 (47), pp.12868-12873. ⟨10.1523/JNEUROSCI.3536-07.2007⟩

Article dans une revue hal-04805044v1
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Network-specific chemogenetic modulation of noradrenergic input to cingulate cortex in macaque

C Gandaux , J Sallet , M Ducret , C Goussi-Denjean , P Misery et al.

Symposium on the Biology of Decision Making SBDM 2025, Jun 2025, Lyon, France

Poster de conférence hal-05136191v1
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MCC-DLPFC network modulation by pathway-specific DREADDs in macaque monkeys: behavioral, resting-state fMRI and histological validation

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Céline Amiez , Delphine Autran-Clavagnier et al.

FENS 2024, Jul 2024, Vienna, Austria

Poster de conférence hal-04971286v1
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The neurophysiological basis of learning to learn in macaque monkeys

Marion Ducret , Emmanuel Procyk , Charles R E Wilson

FENS 2024, Jun 2024, Vienna, Austria

Poster de conférence hal-04969210v1
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Frontal network modulations by pathway-selective chemogenetics modify behaviour of monkeys in a spatial foraging task

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Marion Ducret , Valentine Morel-Latour et al.

Foraging Meeting 2024, Dec 2024, Lyon, France

Poster de conférence hal-04971315v1
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Transcranial ultrasound neuromodulation induces metabolic and resting-state changes in amygdala

J Claron , C Giacometti , S Manickam , V Morel-Latour , C R E Wilson et al.

FENS 2024, Jul 2024, Vienna, Austria

Poster de conférence hal-05136208v1
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The neurophysiological basis of learning to learn in macaque monkeys

Marion Ducret , Emmanuel Procyk , Charles R E Wilson

Motivation and Cognitive Control, Oct 2023, Lyon, France

Poster de conférence hal-04969235v1
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The neurophysiological basis of learning in naive macaque monkeys

Marion Ducret , Emmanuel Procyk , Charles R E Wilson

NeuroFrance 2023, May 2023, Lyon, France

Poster de conférence hal-04969300v1
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Environment reward structure shapes exploration and strategy in humans and non-human primates

Mojtaba Alavi , Charles R E Wilson , Emmanuel Procyk , S. Ben Hamed

NeuroFrance 2023, May 2023, Lyon, France

Poster de conférence hal-04969348v1
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Frontal beta burst properties are an index of motivation and apathy in a macaque model; of Parkinson’s disease

Charles R E Wilson , Agathe Godet , Zachary D Langford , Emmanuel Procyk

Motivation and Cognitive Control, Oct 2023, Lyon, France

Poster de conférence hal-04969229v1
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Learning to learn about feedback, and about uncertain feedback

Charles R E Wilson , Marion Ducret , Maïlys C.M. Faraut , Emmanuel Procyk

FENS Brain Conference: Structuring Knowledge for Flexible Behaviour, Oct 2023, Rungstedgaard, Denmark

Poster de conférence hal-04969220v1
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Network modulation by pathway specific chemogenetics in frontal cortex of macaque monkey

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Céline Amiez , Delphine Autran-Clavagnier et al.

NeuroFrance 2023, Jun 2023, Lyon, France

Poster de conférence hal-04971306v1
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Description of foraging behavior in a naturalistic search task in macaque monkey: Behavioural description and LC/NA-MCC network modulation with pathway-specific chemogenetic

Clémence Gandaux , Charles R E Wilson , Marion Ducret , Valentine Morel-Latour , Pierre Misery et al.

Motivation and Cognitive Control, Oct 2023, Lyon, France

Poster de conférence hal-04969286v1
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What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson

NeuroFrance 2023, May 2023, Lyon, France

Poster de conférence hal-04969297v1
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MCC-DLPFC network modulation by pathway-specific DREADDs in macaque monkeys: behavioral, restingstate fMRI and histological validation

Clémence Gandaux , Charles R E Wilson , Jérôme Sallet , Céline Amiez , Delphine Autran-Clavagnier et al.

ViMaMo 2022, Oct 2022, Paris, France

Poster de conférence hal-04969408v1
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Beta oscillations and its role in cognitive control

Marion Ducret , Charles R E Wilson

GDR NeuralNet 2022, Sep 2022, Lyon, France

Poster de conférence hal-04969394v1
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What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson

GDR Neural Net 2022, Sep 2022, Lyon, France

Poster de conférence hal-04969389v1
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What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson

FENS 2022, Jul 2022, Paris, France

Poster de conférence hal-04969398v1
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What is a burst? How to systematically detect single trial oscillatory dynamics.

Zachary D Langford , Emmanuel Procyk , Charles R E Wilson

Symposium on Biology of Decision Making, May 2021, Paris, France

Poster de conférence hal-04970802v1
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Development of pathway specific DREADDs in macaque monkeys: behavioral and histological studies

Clémence Gandaux , Delphine Autran-Clavagnier , Clément Goussi , Marina Lavigne , Eric Kremer et al.

NeuroFrance 2021, May 2021, Paris, France

Poster de conférence hal-04970773v1
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Meta-learning, cognitive control, and physiological interactions between medial and lateral prefrontal cortex

Mehdi Khamassi , Charles R E Wilson , Marie Rothé , René Quilodran , Peter F Dominey et al.

Mars, R., Sallet, J., Rushworth, M. and Yeung, N. (Eds.), Neural Bases of Motivational and Cognitive Control, MIT Press, 2011

Chapitre d'ouvrage hal-03415847v1