christophe Girard

Chargé de recherche
31
Documents

Présentation

Situation et Adresse professionnelle actuelle

Chargé de Recherche 1ere classe CNRS

Centre Méditerranéen de Médecine Moléculaire (C3M)

Equipe 11 : 'Microenvironnement, signalisation et Cancer'

INSERM U1065, Bâtiment Archimed,

151 Route de Saint Antoine de Ginestière

BP2 3194

06204 Nice

email : christophe.girard@univ-cotedazur.fr

Tel : 33 4 89 15 38 52

Fax : 33 4 89 06 42 21

Internet : http://www.unice.fr/c3m/

Publications

13
10
5
1
1
1
5
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
7
7
6
6
5
5
5
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
2
1
2
2
4
1
1
1
3
1
2
2
4
4
14
9
3
3
1
1

Publications

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

Pierric Biber , Alexandrine Carminati , Walaa Mohager , Mickael Ohanna , Christophe Girard et al.

Cell Reports, 2025, 44 (10), pp.116372. ⟨10.1016/j.celrep.2025.116372⟩

Article dans une revue hal-05347222v1
Deposit thumbnail

Secretion of IL1 by Dedifferentiated Melanoma Cells Inhibits JAK1-STAT3-Driven Actomyosin Contractility of Lymph Node Fibroblastic Reticular Cells

Christopher Rovera , Ilona Berestjuk , Margaux Lecacheur , Cassandre Tavernier , Serena Diazzi et al.

Cancer Research, 2022, 82 (9), pp.1774-1788. ⟨10.1158/0008-5472.CAN-21-0501⟩

Article dans une revue inserm-03674501v1
Deposit thumbnail

Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma

Serena Diazzi , Alberto Baeri , Julien Fassy , Margaux Lecacheur , Oskar Marin‐bejar et al.

EMBO Molecular Medicine, 2022, 14 (3), ⟨10.15252/emmm.202115295⟩

Article dans une revue inserm-03574667v1

Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma

Ilona Berestjuk , Margaux Lecacheur , Alexandrine Carminati , Serena Diazzi , Christopher Rovera et al.

EMBO Molecular Medicine, 2021, ⟨10.15252/emmm.201911814⟩

Article dans une revue hal-03533365v1
Deposit thumbnail

A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma

Christophe Girard , Margaux Lecacheur , Rania Ben Jouira , Ilona Berestjuk , Serena Diazzi et al.

Cancer Research, 2020, 80 (10), pp.1927-1941. ⟨10.1158/0008-5472.CAN-19-2914⟩

Article dans une revue inserm-02889519v1
Deposit thumbnail

Inhibition of patched drug efflux increases vemurafenib effectiveness against resistant braf(V600E) melanoma

Laurie Signetti , Nelli Elizarov , Méliné Simsir , Agnès Paquet , Dominique Douguet et al.

Cancers, 2020, 12 (6), pp.1500. ⟨10.3390/cancers12061500⟩

Article dans une revue hal-02884136v1
Deposit thumbnail

Échappement thérapeutique du mélanome : la piste biomécanique

Margaux Lecacheur , Christophe A. Girard , Marcel Deckert , Sophie Tartare-Deckert

Médecine/Sciences, 2020, 36 (11), pp.961-965. ⟨10.1051/medsci/2020201⟩

Article dans une revue hal-02991398v1
Deposit thumbnail

Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway

M. Rathore , Christophe Girard , M. Ohanna , M. Tichet , R. Ben Jouira et al.

Oncogene, 2019, 38 (30), pp.5873-5889. ⟨10.1038/s41388-019-0848-9⟩

Article dans une revue hal-02323965v1

Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy

Barbara Seitz-Polski , Guillaume Dolla , Christine Payré , Christophe Girard , Joel Polidori et al.

Journal of the American Society of Nephrology, 2016, 27, pp.1517-33

Article dans une revue hal-01455661v1
Deposit thumbnail

Nouveaux rôles physiopathologiques pour le récepteur PLA2R1 dans le cancer et la glomérulonéphrite extramembraneuse

Christophe Girard , Barbara Seitz Seitz-Polski , Guillaume Dolla , Arnaud Augert , David Vindrieux et al.

Médecine/Sciences, 2014, 30 (5), pp.519-525. ⟨10.1051/medsci/20143005014⟩

Article dans une revue hal-03016069v1

PLA2R1 kills cancer cells by inducing mitochondrial stress

Arnaud Augert , David Vindrieux , Christophe Girard , Benjamin Le Calvé , Baptiste Gras et al.

Free Radical Biology and Medicine, 2013, 65, pp.969-977. ⟨10.1016/j.freeradbiomed.2013.08.177⟩

Article dans une revue istex hal-02395811v1

PLA2R1 Mediates Tumor Suppression by Activating JAK2

David Vindrieux , Arnaud Augert , Christophe Girard , Delphine Gitenay , Helene Lallet-Daher et al.

Cancer Research, 2013, 73 (20), pp.6334-6345. ⟨10.1158/0008-5472.CAN-13-0318⟩

Article dans une revue hal-02395807v1

Group X Secreted Phospholipase A2 Limits the Development of Atherosclerosis in LDL Receptor–Null Mice

Hafid Ait Oufella , Alain Tedgui , Makoto Murakami , Olivier Herbin , Charlotte Lahoute et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (3), pp.466-473. ⟨10.1161/ATVBAHA.112.300309⟩

Article dans une revue hal-03016106v1

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

Christophe Girard

Cell Metabolism, 2011, 13 (4), pp.440-449. ⟨10.1016/j.cmet.2011.02.012⟩

Article dans une revue hal-03016133v1

Overexpression of Fto leads to increased food intake and results in obesity

Chris Church , Christophe Girard , Lydia Teboul , Jens Brüning , P.M. Nolan et al.

Nature Genetics, 2010, 42 (12), pp.1086-1092. ⟨10.1038/ng.713⟩

Article dans une revue hal-03016713v1

Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.

Makoto Murakami , Yoshitaka Taketomi , Christophe Girard , Kei Yamamoto , Gérard Lambeau

Biochimie, 2010, 92 (6), pp.561-82. ⟨10.1016/j.biochi.2010.03.015⟩

Article dans une revue istex hal-00497527v1

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

Christophe Girard

Journal of Clinical Investigation, 2009, ⟨10.1172/JCI35772⟩

Article dans une revue hal-03016127v1

Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism

Christophe Girard

EMBO Molecular Medicine, 2009, 1 (3), pp.166-177. ⟨10.1002/emmm.200900018⟩

Article dans une revue hal-03016139v1

Permanent Neonatal Diabetes Caused by Dominant, Recessive, or Compound Heterozygous SUR1 Mutations with Opposite Functional Effects

Christophe Girard

American Journal of Human Genetics, 2007, 81 (2), pp.375-382. ⟨10.1086/519174⟩

Article dans une revue hal-03016441v1

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Thomas Gerken , Christophe Girard , Frances M. Ashcroft

Science, 2007, 318 (5855), pp.1469-1472. ⟨10.1126/science.1151710⟩

Article dans une revue hal-03016428v1

Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11

Christophe Girard

Nature Clinical Practice Neurology, 2007, 3 (11), pp.640-645. ⟨10.1038/ncpneuro0640⟩

Article dans une revue hal-03016431v1

Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome

Christophe Girard

Human Molecular Genetics, 2007, 16 (16), pp.2011-2019. ⟨10.1093/hmg/ddm149⟩

Article dans une revue hal-03016446v1

Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects

Kenju Shimomura , Christophe Girard , Frances M. Ashcroft

Diabetes, 2006, 55 (6), pp.1705-1712. ⟨10.2337/db05-1640⟩

Article dans une revue hal-03016473v1

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes

Christophe Girard , Frances M. Ashcroft

Pflügers Archiv European Journal of Physiology, 2006, 453 (3), pp.323-332. ⟨10.1007/s00424-006-0112-3⟩

Article dans une revue hal-03016452v1

ATP Sensitivity of the ATP-Sensitive K + Channel in Intact and Permeabilized Pancreatic β-Cells

Andrei I. Tarasov , Christophe Girard , Frances M. Ashcroft

Diabetes, 2006, 55 (9), pp.2446-2454. ⟨10.2337/db06-0360⟩

Article dans une revue hal-03016460v1

Functional Effects of Mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy

Peter Proks , Christophe Girard , Frances M. Ashcroft

Diabetes, 2006, 55 (6), pp.1731-1737. ⟨10.2337/db05-1420⟩

Article dans une revue hal-03016732v1