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Christophe Guignabert

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Identifiants chercheurs

Présentation

**Christophe Guignabert, PhD, ATSF, FERS,** is a Research Director (DR1 ) - Full Professor of Molecular Biology & Physiology - at the french Institute of Health and Medical Research (INSERM), where he works at the University Paris Saclay school of medicine. He is an accomplished expert in the molecular mechanisms underlying Pulmonary Hypertension, with a strong track record of innovative research in the field. Dr. Guignabert obtained his Ph.D. in Cell Biology and Cardiovascular Research from the University Paris-Est Créteil (UPEC) in France, where he investigated extracellular remodeling and its role in epithelial alveolar repair. He then completed a postdoctoral fellowship at Stanford University, where he focused on vascular remodeling. Currently, Dr. Guignabert leads a dynamic research team **Endothelial dysfunction and therapeutic innovation in Pulmonary Hypertension** at UMR_S 999. Their research is aimed at uncovering the molecular and cellular mechanisms driving vascular remodeling in Pulmonary Hypertension, with the ultimate goal of identifying new therapeutic targets to improve patient outcomes. Dr. Guignabert's research specifically focuses on how dysfunction in the BMP/TGF-β superfamily modulates the phenotypic heterogeneity of the pulmonary endothelium, and how pulmonary endothelial cells interact with their environment. His innovative work is advancing our understanding of this complex disease and laying the foundation for novel treatments. ***Scientific Focus:*** Pulmonary arterial hypertension (PAH) – Pulmonary vascular remodeling – Endothelial dysfunction – Cell microenvironment – Pericyte – BMP/TGF – Endothelial cell – Growth factors – Preclinical models. ***Specialities:*** Cellular and Molecular Biology - Physiology ***[Lab Website (UMR\_S 999)](http://www.u999.universite-paris-saclay.fr/en/team-1/pah-physiology-topics.html "Lab Website (UMR_S 999)")***

Publications

Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors

T. Al Tabosh , H. Liu , D. Koça , M. Al Tarrass , L. Tu
Article dans une revue hal-04478405v1
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Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension

Christophe Guignabert , Laurent Savale , Athénaïs Boucly , Raphaël Thuillet , Ly Tu
Circulation, 2023, 147 (24), pp.1809-1822. ⟨10.1161/CIRCULATIONAHA.122.061501⟩
Article dans une revue hal-04092113v1

Cytokines as prognostic biomarkers in pulmonary arterial hypertension

Athénaïs Boucly , Ly Tu , Christophe Guignabert , Christopher Rhodes , Pascal de Groote
European Respiratory Journal, 2023, 61 (3), pp.2201232. ⟨10.1183/13993003.01232-2022⟩
Article dans une revue hal-04520048v1

Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats

Matthieu Leuillier , Valentin Platel , Ly Tu , Guillaume Feugray , Raphaël Thuillet
Cells, 2023, 12 (4), pp.665. ⟨10.3390/cells12040665⟩
Article dans une revue hal-04532894v1

Endothelial cells in pulmonary fibrosis: more than a bystander

Toyoshi Yanagihara , Christophe Guignabert , Martin R.J. Kolb
European Respiratory Journal, 2023, 61 (6), pp.2300407. ⟨10.1183/13993003.00407-2023⟩
Article dans une revue hal-04532858v1

Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension

Christophe Guignabert , Laurent Savale , Athénaïs Boucly , Raphaël Thuillet , Ly Tu
Circulation, 2023, 147 (24), pp.1809-1822. ⟨10.1161/CIRCULATIONAHA.122.061501⟩
Article dans une revue hal-04519677v1
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Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension

Julien Solinc , Jessica Raimbault‐machado , France Dierick , Lamiaa El Bernoussi , Ly Tu
Journal of the American Heart Association, 2022, ⟨10.1161/JAHA.121.023021⟩
Article dans une revue hal-03629264v1

Erythrocytes are altered in pulmonary arterial hypertension

Etienne-Marie Jutant , Ly Tu , Raphaël Thuillet , Véronique Picard , Christophe Guignabert
European Respiratory Journal, 2022, 59 (6), pp.2200506. ⟨10.1183/13993003.00506-2022⟩
Article dans une revue hal-04532754v1
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Cytokines as Prognostic Biomarkers in Pulmonary Arterial Hypertension

Athénaïs Boucly , Ly Tu , Christophe Guignabert , Christopher Rhodes , Pascal de Groote
European Respiratory Journal, inPress, pp.2201232. ⟨10.1183/13993003.01232-2022⟩
Article dans une revue hal-03911708v1
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Smooth muscle Rac1 contributes to pulmonary hypertension

Florian Dilasser , Marc Rio , Lindsay Rose , Angela Tesse , Christophe Guignabert
British Journal of Pharmacology, 2022, Online ahead of print. ⟨10.1111/bph.15805⟩
Article dans une revue inserm-03558860v1
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Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells

Benjamin Le Vely , Carole Phan , Nihel Berrebeh , Raphaël Thuillet , Mina Ottaviani
American Journal of Respiratory Cell and Molecular Biology, 2022, Online ahead of print. ⟨10.1165/rcmb.2021-0332oc⟩
Article dans une revue inserm-03678207v1
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New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis

Micheala Aldred , Nicholas Morrell , Christophe Guignabert
Circulation Research, 2022, 130 (9), pp.1365-1381. ⟨10.1161/CIRCRESAHA.122.320084⟩
Article dans une revue inserm-03654919v1
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IL ‐2‐related regulatory CD4 T‐cell deficiency leads to the development of lung fibrosis and vascular remodeling

Camelia Frantz , Anne Cauvet , Aurélie Durand , Virginie Gonzalez , Rémi Pierre
Arthritis & rheumatology, 2022, Online ahead of print. ⟨10.1002/art.42111⟩
Article dans une revue inserm-03652770v1
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Smooth muscle Rac1 contributes to pulmonary hypertension Short running title: Role of Rac1 in pulmonary hypertension

Florian Dilasser , Marc Rio , Lindsay Rose , Angela Tesse , Christophe Guignabert
British Journal of Pharmacology, inPress
Article dans une revue hal-03582408v1

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

Claire Bouvard , Ly Tu , Martina Rossi , Agnès Desroches-Castan , Nihel Berrebeh
Cardiovascular Research, 2021, pp.cvab187. ⟨10.1093/cvr/cvab187⟩
Article dans une revue hal-03453979v1
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Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

Claire Bouvard , Ly Tu , Martina Rossi , Agnès Desroches-Castan , Nihel Berrebeh
Cardiovascular Research, 2021, 118 (7), pp.1805-1820. ⟨10.1093/cvr/cvab187⟩
Article dans une revue hal-03264032v1

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

Gusty Ryanto , Koji Ikeda , Kazuya Miyagawa , Ly Tu , Christophe Guignabert
Nature Communications, 2021, 12 (1), pp.1720. ⟨10.1038/s41467-021-21961-3⟩
Article dans une revue hal-04532633v1
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Cibler les ligands du récepteur de l’activine de type IIA pour traiter l’hypertension artérielle pulmonaire

Marc Humbert , David Montani , Laurent Savale , Ly Tu , Christophe Guignabert
Médecine/Sciences, 2021, 37 (10), pp.839-843. ⟨10.1051/medsci/2021131⟩
Article dans une revue hal-03379128v1
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The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy

Nicolas Ricard , Sabine Bailly , Christophe Guignabert , Michael Simons
Nature Reviews Cardiology, 2021, 18, pp.565-580. ⟨10.1038/s41569-021-00517-4⟩
Article dans une revue inserm-03153011v1
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Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort

Jessie van Wezenbeek , Joanne A Groeneveldt , Aida Llucià-Valldeperas , Cathelijne E van Der Bruggen , Samara M A Jansen
The Journal of Heart and Lung Transplantation, 2021, Online ahead of print. ⟨10.1016/j.healun.2021.11.004⟩
Article dans une revue inserm-03558871v1
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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation

David Montani , Barbara Girerd , Xavier Jaïs , Pierantonio Laveneziana , Edmund M.T. Lau
European Respiratory Journal, 2021, 58 (1), pp.2004229. ⟨10.1183/13993003.04229-2020⟩
Article dans une revue hal-04007994v1

Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?

Thomas Duflot , Ly Tu , Matthieu Leuillier , Hind Messaoudi , Déborah Groussard
Metabolites, 2021, 11 (11), pp.784. ⟨10.3390/metabo11110784⟩
Article dans une revue hal-04532610v1
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Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

Florian Dilasser , Lindsay Rose , Dorian Hassoun , Martin Klein , Morgane Rousselle
Article dans une revue hal-03142499v1
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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation

David Montani , Barbara Girerd , Xavier Jaïs , Pierantonio Laveneziana , Edmund M T Lau
European Respiratory Journal, In press, ⟨10.1183/13993003.04229-2020⟩
Article dans une revue hal-03104056v1
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Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension

Laurent Savale , Satoshi Akagi , Ly Tu , Amélie Cumont , Raphaël Thuillet
European Respiratory Journal, 2021, 58 (2), pp.2000332. ⟨10.1183/13993003.00332-2020⟩
Article dans une revue inserm-03118201v1

Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention

Takayuki Jujo Sanada , Xiao-Qing Sun , Chris Happé , Christophe Guignabert , Ly Tu
Cells, 2021, 10 (1), pp.84. ⟨10.3390/cells10010084⟩
Article dans une revue hal-04526974v1

Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

Alice Huertas , David Montani , Laurent Savale , Jérémie Pichon , Ly Tu
European Respiratory Journal, 2020, 56 (1), pp.2001634. ⟨10.1183/13993003.01634-2020⟩
Article dans une revue hal-04526866v1
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Dendritic Cells in Pulmonary Hypertension: Foot Soldiers or Hidden Enemies?

Christophe Guignabert
American Journal of Respiratory Cell and Molecular Biology, 2020, ⟨10.1165/rcmb.2020-0330ED⟩
Article dans une revue inserm-02918859v1
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Multiple roles of macrophage migration inhibitory factor in pulmonary hypertension

Gael Jalce , Christophe Guignabert
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2020, 318 (1), pp.L1-L9. ⟨10.1152/ajplung.00234.2019⟩
Article dans une revue inserm-02454988v1
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Targeting Transforming Growth Factor Beta Receptors in Pulmonary Hypertension

Christophe Guignabert , Marc Humbert
European Respiratory Journal, 2020, pp.2002341. ⟨10.1183/13993003.02341-2020⟩
Article dans une revue inserm-02918857v1
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Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension

Jennifer Bordenave , Ly Tu , Nihel Berrebeh , Raphaël Thuillet , Amélie Cumont
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (3), pp.766-782. ⟨10.1161/ATVBAHA.119.313715⟩
Article dans une revue inserm-02454982v2
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Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension

Marie-Camille Chaumais , Mohamed Reda Amar Djessas , Raphaël Thuillet , Amélie Cumont , Ly Tu
Cardiovascular Research, 2020, pp.cvaa200. ⟨10.1093/cvr/cvaa200⟩
Article dans une revue inserm-02907132v1
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Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

Zongye Cai , Theo Klein , Laurie Geenen , Ly Tu , Siyu Tian
Journal of Clinical Medicine, 2020, 9 (5), pp.1248. ⟨10.3390/jcm9051248⟩
Article dans une revue inserm-02581568v1

Pulmonary complications of Bcr-Abl tyrosine kinase inhibitors

Jason Weatherald , Louise Bondeelle , Marie-Camille Chaumais , Christophe Guignabert , Laurent Savale
European Respiratory Journal, 2020, 56 (4), pp.2000279. ⟨10.1183/13993003.00279-2020⟩
Article dans une revue hal-04526808v1

The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

Chris Happé , Kondababu Kurakula , Xiao-Qing Sun , Denielli da Silva Goncalves Bos , Nina Rol
Cells, 2020, 9 (6), pp.1422. ⟨10.3390/cells9061422⟩
Article dans une revue hal-04526850v1

Connexin 43 Is a Promising Target for Pulmonary Hypertension due To Hypoxemic Lung Disease

Claire Bouvard , Nafiisha Genet , Baptiste Rode , Raphaël Thuillet , Ly Tu
European Respiratory Journal, 2020, 55 (3), pp.1900169. ⟨10.1183/13993003.00169-2019⟩
Article dans une revue hal-02430904v1

Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator

Alice Huertas , Ly Tu , Marc Humbert , Christophe Guignabert
Cardiovascular Research, 2019, pp.cvz308. ⟨10.1093/cvr/cvz308⟩
Article dans une revue inserm-02454983v1
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Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

Edda Spiekerkoetter , Elena Goncharova , Christophe Guignabert , Kurt Stenmark , Grazyna Kwapiszewska
Pulmonary circulation / Pulm Circ, 2019, 9 (4), pp.204589401988977. ⟨10.1177/2045894019889775⟩
Article dans une revue inserm-02612634v1

Functional interaction between PDGFβ and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension

Marceau Quatredeniers , K Nakhleh Morad , J Dumas Sebastien , Audrey Courboulin , C Vinhas Maria
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2019, 316 (3), pp.L445-L455. ⟨10.1152/ajplung.00537.2017⟩
Article dans une revue hal-02411597v1
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Nouveau regard sur la physiopathologie de l’hypertension artérielle pulmonaire

Jennifer Bordenave , Ly Tu , Laurent Savale , Alice Huertas , Marc Humbert
Revue des Maladies Respiratoires, 2019, 36 (4), pp.433-437. ⟨10.1016/j.rmr.2019.03.003⟩
Article dans une revue inserm-02454990v1
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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

Ly Tu , Agnes Desroches-Castan , Christine Mallet , Laurent Guyon , Amélie Cumont
Circulation Research, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩
Article dans une revue inserm-02581297v1

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Marc Humbert , Christophe Guignabert , Sébastien Bonnet , Peter Dorfmüller , James Klinger
European Respiratory Journal, 2019, 53 (1), pp.1801887. ⟨10.1183/13993003.01887-2018⟩
Article dans une revue inserm-02612658v1

Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling

Kondababu Kurakula , Xiao-Qing Sun , Chris Happé , Denielli da Silva Goncalves Bos , Robert Szulcek
European Respiratory Journal, 2019, 54 (3), pp.1802400. ⟨10.1183/13993003.02400-2018⟩
Article dans une revue inserm-02612640v1

Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets

Sven Günther , Paolo Fagone , Gaël Jalce , Atanas Atanasov , Christophe Guignabert
Drug Discovery Today, 2019, 24 (2), pp.428-439. ⟨10.1016/j.drudis.2018.11.003⟩
Article dans une revue hal-04526640v1
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Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat

Jennifer Bordenave , Raphaël Thuillet , Ly Tu , Carole Phan , Amélie Cumont
Cardiovascular Research, In press, pp.cvz153. ⟨10.1093/cvr/cvz153⟩
Article dans une revue hal-02195697v1

Pharmacovigilance in a rare disease: example of the VIGIAPATH program in pulmonary arterial hypertension

Marie-Camille Chaumais , Caroline O’connell , Laurent Savale , Christophe Guignabert , Frédéric Perros
International Journal of Clinical Pharmacy, 2018, 40 (4), pp.790-794. ⟨10.1007/s11096-018-0712-y⟩
Article dans une revue hal-04526544v1

Optimising experimental research in respiratory diseases: an ERS statement

Philippe Bonniaud , Aurélie Fabre , Nelly Frossard , Christophe Guignabert , Mark Inman
European Respiratory Journal, 2018, 51 (5), pp.1702133. ⟨10.1183/13993003.02133-2017⟩
Article dans une revue hal-04275732v1

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

Yuichi Tamura , Carole Phan , Ly Tu , Morane Le Hiress , Raphaël Thuillet
Journal of Clinical Investigation, 2018, 128 (5), pp.1956-1970. ⟨10.1172/JCI96462⟩
Article dans une revue inserm-02580448v1
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Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

Tinne Mertens , Ankit Hanmandlu , Ly Tu , Carole Phan , Scott Collum
Frontiers in Physiology, 2018, 9, pp.555. ⟨10.3389/fphys.2018.00555⟩
Article dans une revue inserm-02580921v1

Dasatinib increases endothelial permeability leading to pleural effusion

Carole Phan , Etienne-Marie Jutant , Ly Tu , Raphaël Thuillet , Andrei Seferian
European Respiratory Journal, 2018, 51 (1), pp.1701096. ⟨10.1183/13993003.01096-2017⟩
Article dans une revue inserm-02580192v1

Design, Synthesis, and Biological Activity of New N -(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension

Morane Le Hiress , Bernardin Akagah , Guillaume Bernadat , Ly Tu , Raphaël Thuillet
Journal of Medicinal Chemistry, 2018, 61 (7), pp.2725-2736. ⟨10.1021/acs.jmedchem.7b01312⟩
Article dans une revue inserm-02580381v1

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases

Alice Huertas , Christophe Guignabert , Joan Barberà , Peter Bärtsch , Jahar Bhattacharya
European Respiratory Journal, 2018, 51 (4), pp.1700745. ⟨10.1183/13993003.00745-2017⟩
Article dans une revue hal-04526502v1
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Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension

Paul-Benoit Poble , Carole Phan , Timothée Quatremare , Jennifer Bordenave , Raphaël Thuillet
FASEB Journal, 2018, 33 (3), pp.3670-3679. ⟨10.1096/fj.201801659R⟩
Article dans une revue inserm-02581079v1

ACE2 as therapy for pulmonary arterial hypertension: the good outweighs the bad

Christophe Guignabert , Frances S de Man , Marc M. Lombès
European Respiratory Journal, 2018, 51 (6), pp.1800848. ⟨10.1183/13993003.00848-2018⟩
Article dans une revue inserm-02582393v1

Optimising experimental research in respiratory diseases: an ERS statement

Philippe Bonniaud , Aurélie Fabre , Nelly Frossard , Christophe Guignabert , Mark Inman
European Respiratory Journal, 2018, 51 (5), pp.1702133. ⟨10.1183/13993003.02133-2017⟩
Article dans une revue hal-01996906v1
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Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis

Sven Günther , Jennifer Bordenave , Thông Hua-Huy , Carole Nicco , Amélie Cumont
International Journal of Molecular Sciences, 2018, 19 (12), pp.4105. ⟨10.3390/ijms19124105⟩
Article dans une revue inserm-02612651v1

[IL6R is the key therapeutical target in pulmonary arterial hypertension]

Ly Tu , Carole Phan , Marc Humbert , Christophe Guignabert
Médecine/Sciences, 2018, 34 (10), pp.765-768. ⟨10.1051/medsci/2018201⟩
Article dans une revue inserm-02580983v1
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Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension

Alice Huertas , Carole Phan , Jennifer Bordenave , Ly Tu , Raphaël Thuillet
Chest, 2016, 149 (6), pp.1482-1493. ⟨10.1016/j.chest.2016.01.004⟩
Article dans une revue inserm-02593143v1

Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

Christophe Guignabert , Carole Phan , Andrei Seferian , Alice Huertas , Ly Tu
Journal of Clinical Investigation, 2016, 126 (9), pp.3207-3218. ⟨10.1172/JCI86249⟩
Article dans une revue inserm-02579754v1

Vers de nouvelles cibles pour le traitement de l’hypertension artérielle pulmonaire : Importance des communications cellulaires

Ly Tu , Maria-Rosa Ghigna , Carole Phan , Jennifer Bordenave , Morane Le Hiress
Biologie Aujourd'hui, 2016, 210 (2), pp.65-78. ⟨10.1051/jbio/2016010⟩
Article dans une revue inserm-02579962v1
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Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension

Marie-Camille Chaumais , Christophe Guignabert , Laurent Savale , Xavier Jaïs , Athénaïs Boucly
American Journal of Cardiovascular Drugs, 2015, 15 (1), pp.13-26. ⟨10.1007/s40256-014-0095-y⟩
Article dans une revue inserm-03224640v1
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Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension

Véronique Freund-Michel , Marcelina Cardoso dos Santos , Christophe Guignabert , David Montani , Carole Phan
American Journal of Respiratory and Critical Care Medicine, 2015, 192, pp.342 - 355. ⟨10.1164/rccm.201410-1851oc⟩
Article dans une revue hal-03329041v1

Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension

Véronique Freund-Michel , Marcelina Cardoso dos Santos , Christophe Guignabert , David Montani , Carole Phan
American Journal of Respiratory and Critical Care Medicine, 2015, 192 (3), pp.342-355. ⟨10.1164/rccm.201410-1851OC⟩
Article dans une revue inserm-02578672v1

Telomere Maintenance Is a Critical Determinant in the Physiopathology of Pulmonary Hypertension

Mohamed Izikki , Eric Hoang , Irena Draskovic , Olaf Mercier , Florence Lecerf
Journal of the American College of Cardiology, 2015, 66 (17), pp.1942 - 1943. ⟨10.1016/j.jacc.2015.08.869⟩
Article dans une revue hal-01764142v1

Leptin signalling system as a target for pulmonary arterial hypertension therapy

Alice Huertas , Ly Tu , Raphaël Thuillet , Morane Le Hiress , Carole Phan
European Respiratory Journal, 2015, 45 (4), pp.1066-1080. ⟨10.1183/09031936.00193014⟩
Article dans une revue inserm-02579431v1
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Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex

Morane Le Hiress , Ly Tu , Nicolas Ricard , Carole Phan , Raphaël Thuillet
American Journal of Respiratory and Critical Care Medicine, 2015, 192 (8), pp.983-997. ⟨10.1164/rccm.201402-0322OC⟩
Article dans une revue inserm-02579320v1
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Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension

Nicolas Ricard , Ly Tu , Morane Le Hiress , Alice Huertas , Carole Phan
Circulation, 2014, 129 (15), pp.1586-1597. ⟨10.1161/CIRCULATIONAHA.113.007469⟩
Article dans une revue inserm-02578269v1

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

Marine Germain , Mélanie Eyries , David Montani , Odette Poirier , Barbara Girerd
Nature Genetics, 2013, 45 (5), pp.518-521. ⟨10.1038/ng.2581⟩
Article dans une revue hal-02565627v1
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A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.

Ly Tu , Frances S. de Man , Barbara Girerd , Alice Huertas , Marie-Camille Chaumais
American Journal of Respiratory and Critical Care Medicine, 2012, 186 (7), pp.666-76. ⟨10.1164/rccm.201202-0309OC⟩
Article dans une revue inserm-00905191v1
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Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension.

Alice Huertas , Ly Tu , Natalia Gambaryan , Barbara Girerd , Frédéric Perros
European Respiratory Journal, 2012, 40 (4), pp.895-904. ⟨10.1183/09031936.00159911⟩
Article dans une revue inserm-00913076v1

Pulmonary arterial hypertension in patients treated by dasatinib.

David Montani , Emmanuel Bergot , Sven Günther , Laurent Savale , Anne Bergeron
Circulation, 2012, 125 (17), pp.2128-37. ⟨10.1161/CIRCULATIONAHA.111.079921⟩
Article dans une revue inserm-00697146v1
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Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.

Frances S. de Man , Ly Tu , Louis Handoko , Silvia Rain , Gerrina Ruiter
American Journal of Respiratory and Critical Care Medicine, 2012, 186 (8), pp.780-9. ⟨10.1164/rccm.201203-0411OC⟩
Article dans une revue inserm-00905193v1
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Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension.

Ly Tu , Laurence Dewachter , Benoit Gore , Elie Fadel , Philippe Dartevelle
American Journal of Respiratory Cell and Molecular Biology, 2011, 45 (2), pp.311-22. ⟨10.1165/rcmb.2010-0317OC⟩
Article dans une revue inserm-00579959v1
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Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

Christophe Guignabert , Ly Tu , Mohamed Izikki , Laurence Dewachter , Patricia Zadigue
FASEB Journal, 2009, 23 (12), pp.4135-47. ⟨10.1096/fj.09-131664⟩
Article dans une revue inserm-00499630v1
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Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension.

Laurence Dewachter , Serge Adnot , Christophe Guignabert , Ly Tu , Elisabeth Marcos
European Respiratory Journal, 2009, 34 (5), pp.1100-10. ⟨10.1183/09031936.00183008⟩
Article dans une revue inserm-00433927v1
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Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

Christophe Guignabert , Cristina Alvira , Tero-Pekka Alastalo , Hirofumi Sawada , Georg Hansmann
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2009, 297 (6), pp.L1082-90. ⟨10.1152/ajplung.00199.2009⟩
Article dans une revue inserm-00499633v1
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Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents.

Mohamed Izikki , Christophe Guignabert , Elie Fadel , Marc Humbert , Ly Tu
Journal of Clinical Investigation, 2009, 119 (3), pp.512-23. ⟨10.1172/JCI35070⟩
Article dans une revue inserm-00499635v1
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Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension.

Christophe Guignabert , Mohamed Izikki , Ly Ieng Tu , Zhenlin Li , Patricia Zadigue
Circulation Research, 2006, 98 (10), pp.1323-30. ⟨10.1161/01.RES.0000222546.45372.a0⟩
Article dans une revue inserm-00499636v1
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Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing.

François Maquerlot , Stéphane D. Galiacy , Michel Malo , Christophe Guignabert , Daniel A. Lawrence
American Journal of Pathology, 2006, 169 (5), pp.1624-32
Article dans une revue inserm-00186832v1
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Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.

Christophe Guignabert , Bernadette Raffestin , Rima Benferhat , William Raoul , Patricia Zadigue
Circulation, 2005, 111 (21), pp.2812-9. ⟨10.1161/CIRCULATIONAHA.104.524926⟩
Article dans une revue inserm-00499643v1
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Effect of doxycycline on sulfur mustard-induced respiratory lesions in guinea pigs.

Christophe Guignabert , Laurent Taysse , Jean-Henri Calvet , Emmanuelle Planus , Séraphin Delamanche
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2005, 289 (1), pp.L67-74. ⟨10.1152/ajplung.00475.2004⟩
Article dans une revue inserm-00499644v1