Christophe Guignabert

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Publications

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Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling

Nihel Berrebeh , Yvon Mbouamboua , Raphaël Thuillet , Mina Ottaviani , Fabien Robert et al.

Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (26), ⟨10.1073/pnas.2410229122⟩

Article dans une revue hal-05190343v1
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Evolving paradigms in pulmonary hypertension: Highlights of the 6th French Pulmonary Hypertension Network Meeting

Athénaïs Boucly , Antoine Beauvais , Thomas Lacoste-Palasset , Mitja Jevnikar , Marianne Riou et al.

Respiratory Medicine and Research, 2025, 88, pp.101215. ⟨10.1016/j.resmer.2025.101215⟩

Article dans une revue hal-05468026v1
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Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome

Fabien Robert , Marie-Caroline Certain , Audrey Baron , Raphaël Thuillet , Léa Duhaut et al.

American Journal of Respiratory and Critical Care Medicine, 2024, 210 (5), pp.648 - 661. ⟨10.1164/rccm.202307-1289oc⟩

Article dans une revue hal-05202933v1
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Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome

Fabien Robert , Feriel Benchenouf , My Ngoc Ha , Alessandra Cuomo , Mina Ottaviani et al.

JHEP Reports Innovation in Hepatology, 2024, 7 (3), pp.101297. ⟨10.1016/j.jhepr.2024.101297⟩

Article dans une revue hal-05190311v1

Pulmonary vascular phenotype identified in patients with GDF2 ( BMP9 ) or BMP10 variants: an international multicentre study

Julien Grynblat , Harm Jan Bogaard , Mélanie Eyries , Olivier Meyrignac , Laurent Savale et al.

European Respiratory Journal, 2024, 63 (4), pp.2301634. ⟨10.1183/13993003.01634-2023⟩

Article dans une revue hal-04651213v1
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Retour triomphant des J2R 2023 à Tours : un tourbillon d’échanges scientifiques et d’émotion

I. Annesi-Maesano , Philippe Bonniaud , G. Bouchaud , L. Boyer , Sylvie Gazzeri et al.

Revue des Maladies Respiratoires, 2024, 41 (3), pp.180-182. ⟨10.1016/j.rmr.2024.03.002⟩

Article dans une revue hal-04550861v1

Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors

T. Al Tabosh , H. Liu , D. Koça , M. Al Tarrass , L. Tu et al.

Angiogenesis, 2024, ⟨10.1007/s10456-023-09902-8⟩

Article dans une revue hal-04478405v1

Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction

Hélène Le Ribeuz , Anaïs Saint-Martin Willer , Benoit Chevalier , Maria Sancho , Bastien Masson et al.

American Journal of Respiratory Cell and Molecular Biology, 2024, 71 (1), pp.95-109. ⟨10.1165/rcmb.2023-0185OC⟩

Article dans une revue hal-04754075v1

Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome

Fabien Robert , Marie-Caroline Certain , Audrey Baron , Raphaël Thuillet , Léa Duhaut et al.

American Journal of Respiratory and Critical Care Medicine, 2024, 210 (5), pp.648-661. ⟨10.1164/rccm.202307-1289OC⟩

Article dans une revue hal-04989021v1

Exploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy

Benchenouf Feriel , Cuomo Alessandra , Gorth Deborah , Normand Corinne , Thuillet Raphaël et al.

Scientific Reports, 2024, 14 (1), pp.28308. ⟨10.1038/s41598-024-79623-5⟩

Article dans une revue hal-04877626v1

Evidence and unresolved questions in pulmonary hypertension: Insights from the 5th French Pulmonary Hypertension Network Meeting

Athénaïs Boucly , Laurent Bertoletti , Charles Fauvel , Mélanie Gallant Dewavrin , Christian Gerges et al.

Respiratory Medicine and Research, 2024, 86, pp.101123. ⟨10.1016/j.resmer.2024.101123⟩

Article dans une revue hal-04953892v1
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Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats

Matthieu Leuillier , Valentin Platel , Ly Tu , Guillaume Feugray , Raphaël Thuillet et al.

Cells, 2023, 12 (4), pp.665. ⟨10.3390/cells12040665⟩

Article dans une revue hal-04532894v1

Endothelial cells in pulmonary fibrosis: more than a bystander

Toyoshi Yanagihara , Christophe Guignabert , Martin R.J. Kolb

European Respiratory Journal, 2023, 61 (6), pp.2300407. ⟨10.1183/13993003.00407-2023⟩

Article dans une revue hal-04532858v1
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Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension

Christophe Guignabert , Laurent Savale , Athénaïs Boucly , Raphaël Thuillet , Ly Tu et al.

Circulation, 2023, 147 (24), pp.1809-1822. ⟨10.1161/CIRCULATIONAHA.122.061501⟩

Article dans une revue hal-04092113v1

Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells

Benjamin Le Vely , Carole Phan , Nihel Berrebeh , Raphaël Thuillet , Mina Ottaviani et al.

American Journal of Respiratory Cell and Molecular Biology, 2022, 67 (2), pp.215-226. ⟨10.1165/rcmb.2021-0332OC⟩

Article dans une revue hal-04608774v1
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Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells

Benjamin Le Vely , Carole Phan , Nihel Berrebeh , Raphaël Thuillet , Mina Ottaviani et al.

American Journal of Respiratory Cell and Molecular Biology, 2022, Online ahead of print. ⟨10.1165/rcmb.2021-0332oc⟩

Article dans une revue inserm-03678207v1
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New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis

Micheala Aldred , Nicholas Morrell , Christophe Guignabert

Circulation Research, 2022, 130 (9), pp.1365-1381. ⟨10.1161/CIRCRESAHA.122.320084⟩

Article dans une revue inserm-03654919v1
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Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension

Siyu Tian , Zongye Cai , Payel Sen , Denise van Uden , Esther van de Kamp et al.

AJP - Heart and Circulatory Physiology, 2022, 323 (5), pp.H958 - H974. ⟨10.1152/ajpheart.00220.2022⟩

Article dans une revue inserm-04270340v1

Erythrocytes are altered in pulmonary arterial hypertension

Etienne-Marie Jutant , Ly Tu , Raphaël Thuillet , Véronique Picard , Christophe Guignabert et al.

European Respiratory Journal, 2022, 59 (6), pp.2200506. ⟨10.1183/13993003.00506-2022⟩

Article dans une revue hal-04532754v1
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Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension

Julien Solinc , Jessica Raimbault‐machado , France Dierick , Lamiaa El Bernoussi , Ly Tu et al.

Journal of the American Heart Association, 2022, ⟨10.1161/JAHA.121.023021⟩

Article dans une revue hal-03629264v1
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Cytokines as Prognostic Biomarkers in Pulmonary Arterial Hypertension

Athénaïs Boucly , Ly Tu , Christophe Guignabert , Christopher Rhodes , Pascal de Groote et al.

European Respiratory Journal, 2022, 61 (3), pp.2201232. ⟨10.1183/13993003.01232-2022⟩

Article dans une revue hal-03911708v1
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Smooth muscle Rac1 contributes to pulmonary hypertension

Florian Dilasser , Marc Rio , Lindsay Rose , Angela Tesse , Christophe Guignabert et al.

British Journal of Pharmacology, 2022, Online ahead of print. ⟨10.1111/bph.15805⟩

Article dans une revue inserm-03558860v1
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Identifying new drugs associated with pulmonary arterial hypertension: A WHO pharmacovigilance database disproportionality analysis

Alex Hlavaty , Matthieu Roustit , David Montani , Marie‐camille Chaumais , Christophe Guignabert et al.

British Journal of Clinical Pharmacology, 2022, 88 (12), pp.5227-5237. ⟨10.1111/bcp.15436⟩

Article dans une revue hal-04520451v1
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Smooth muscle Rac1 contributes to pulmonary hypertension Short running title: Role of Rac1 in pulmonary hypertension

Florian Dilasser , Marc Rio , Lindsay Rose , Angela Tesse , Christophe Guignabert et al.

British Journal of Pharmacology, In press

Article dans une revue hal-03582408v1
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IL ‐2‐related regulatory CD4 T‐cell deficiency leads to the development of lung fibrosis and vascular remodeling

Camelia Frantz , Anne Cauvet , Aurélie Durand , Virginie Gonzalez , Rémi Pierre et al.

Arthritis & rheumatology, 2022, Online ahead of print. ⟨10.1002/art.42111⟩

Article dans une revue inserm-03652770v1
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Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?

Thomas Duflot , Ly Tu , Matthieu Leuillier , Hind Messaoudi , Déborah Groussard et al.

Metabolites, 2021, 11 (11), pp.784. ⟨10.3390/metabo11110784⟩

Article dans une revue hal-04532610v1
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Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

Claire Bouvard , Ly Tu , Martina Rossi , Agnès Desroches-Castan , Nihel Berrebeh et al.

Cardiovascular Research, 2021, 118 (7), pp.1805-1820. ⟨10.1093/cvr/cvab187⟩

Article dans une revue hal-03264032v1

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

Gusty Ryanto , Koji Ikeda , Kazuya Miyagawa , Ly Tu , Christophe Guignabert et al.

Nature Communications, 2021, 12 (1), pp.1720. ⟨10.1038/s41467-021-21961-3⟩

Article dans une revue hal-04532633v1
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Cibler les ligands du récepteur de l’activine de type IIA pour traiter l’hypertension artérielle pulmonaire

Marc Humbert , David Montani , Laurent Savale , Ly Tu , Christophe Guignabert

Médecine/Sciences, 2021, 37 (10), pp.839-843. ⟨10.1051/medsci/2021131⟩

Article dans une revue hal-03379128v1
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Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension

Laurent Savale , Satoshi Akagi , Ly Tu , Amélie Cumont , Raphaël Thuillet et al.

European Respiratory Journal, 2021, 58 (2), pp.2000332. ⟨10.1183/13993003.00332-2020⟩

Article dans une revue inserm-03118201v1

Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention

Takayuki Jujo Sanada , Xiao-Qing Sun , Chris Happé , Christophe Guignabert , Ly Tu et al.

Cells, 2021, 10 (1), pp.84. ⟨10.3390/cells10010084⟩

Article dans une revue hal-04526974v1
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The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy

Nicolas Ricard , Sabine Bailly , Christophe Guignabert , Michael Simons

Nature Reviews Cardiology, 2021, 18, pp.565-580. ⟨10.1038/s41569-021-00517-4⟩

Article dans une revue inserm-03153011v1
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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation

David Montani , Barbara Girerd , Xavier Jaïs , Pierantonio Laveneziana , Edmund M.T. Lau et al.

European Respiratory Journal, 2021, 58 (1), pp.2004229. ⟨10.1183/13993003.04229-2020⟩

Article dans une revue hal-04007994v1
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Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

Florian Dilasser , Lindsay Rose , Dorian Hassoun , Martin Klein , Morgane Rousselle et al. Article dans une revue hal-03142499v2
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Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort

Jessie van Wezenbeek , Joanne A Groeneveldt , Aida Llucià-Valldeperas , Cathelijne E van Der Bruggen , Samara M A Jansen et al.

The Journal of Heart and Lung Transplantation, 2021, 41 (4), Online ahead of print. ⟨10.1016/j.healun.2021.11.004⟩

Article dans une revue inserm-03558871v1
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Multiple roles of macrophage migration inhibitory factor in pulmonary hypertension

Gael Jalce , Christophe Guignabert

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2020, 318 (1), pp.L1-L9. ⟨10.1152/ajplung.00234.2019⟩

Article dans une revue inserm-02454988v1
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Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

Zongye Cai , Theo Klein , Laurie Geenen , Ly Tu , Siyu Tian et al.

Journal of Clinical Medicine, 2020, 9 (5), pp.1248. ⟨10.3390/jcm9051248⟩

Article dans une revue inserm-02581568v1
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Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension

Marie-Camille Chaumais , Mohamed Reda Amar Djessas , Raphaël Thuillet , Amélie Cumont , Ly Tu et al.

Cardiovascular Research, 2020, pp.cvaa200. ⟨10.1093/cvr/cvaa200⟩

Article dans une revue inserm-02907132v1
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Targeting Transforming Growth Factor Beta Receptors in Pulmonary Hypertension

Christophe Guignabert , Marc Humbert

European Respiratory Journal, 2020, pp.2002341. ⟨10.1183/13993003.02341-2020⟩

Article dans une revue inserm-02918857v1

Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease

Claire Bouvard , Nafiisha Genet , Carole Phan , Baptiste Rode , Raphaël Thuillet et al.

European Respiratory Journal, 2020, 55 (3), pp.1900169. ⟨10.1183/13993003.00169-2019⟩

Article dans une revue hal-04608766v1

Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

Alice Huertas , David Montani , Laurent Savale , Jérémie Pichon , Ly Tu et al.

European Respiratory Journal, 2020, 56 (1), pp.2001634. ⟨10.1183/13993003.01634-2020⟩

Article dans une revue hal-04526866v1
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Dendritic Cells in Pulmonary Hypertension: Foot Soldiers or Hidden Enemies?

Christophe Guignabert

American Journal of Respiratory Cell and Molecular Biology, 2020, ⟨10.1165/rcmb.2020-0330ED⟩

Article dans une revue inserm-02918859v1
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Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension

Jennifer Bordenave , Ly Tu , Nihel Berrebeh , Raphaël Thuillet , Amélie Cumont et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (3), pp.766-782. ⟨10.1161/ATVBAHA.119.313715⟩

Article dans une revue inserm-02454982v2

The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

Chris Happé , Kondababu Kurakula , Xiao-Qing Sun , Denielli da Silva Goncalves Bos , Nina Rol et al.

Cells, 2020, 9 (6), pp.1422. ⟨10.3390/cells9061422⟩

Article dans une revue hal-04526850v1

Pulmonary complications of Bcr-Abl tyrosine kinase inhibitors

Jason Weatherald , Louise Bondeelle , Marie-Camille Chaumais , Christophe Guignabert , Laurent Savale et al.

European Respiratory Journal, 2020, 56 (4), pp.2000279. ⟨10.1183/13993003.00279-2020⟩

Article dans une revue hal-04526808v1
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Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

Edda Spiekerkoetter , Elena Goncharova , Christophe Guignabert , Kurt Stenmark , Grazyna Kwapiszewska et al.

Pulmonary Circulation, 2019, 9 (4), pp.204589401988977. ⟨10.1177/2045894019889775⟩

Article dans une revue inserm-02612634v1
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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

Ly Tu , Agnes Desroches-Castan , Christine Mallet , Laurent Guyon , Amélie Cumont et al.

Circulation Research, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩

Article dans une revue inserm-02581297v1

Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets

Sven Günther , Paolo Fagone , Gaël Jalce , Atanas Atanasov , Christophe Guignabert et al.

Drug Discovery Today, 2019, 24 (2), pp.428-439. ⟨10.1016/j.drudis.2018.11.003⟩

Article dans une revue istex hal-04526640v1

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Marc Humbert , Christophe Guignabert , Sébastien Bonnet , Peter Dorfmüller , James Klinger et al.

European Respiratory Journal, 2019, 53 (1), pp.1801887. ⟨10.1183/13993003.01887-2018⟩

Article dans une revue inserm-02612658v1

Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling

Kondababu Kurakula , Xiao-Qing Sun , Chris Happé , Denielli da Silva Goncalves Bos , Robert Szulcek et al.

European Respiratory Journal, 2019, 54 (3), pp.1802400. ⟨10.1183/13993003.02400-2018⟩

Article dans une revue inserm-02612640v1
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Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat

Jennifer Bordenave , Raphaël Thuillet , Ly Tu , Carole Phan , Amélie Cumont et al.

Cardiovascular Research, inPress, pp.cvz153. ⟨10.1093/cvr/cvz153⟩

Article dans une revue hal-02195697v1
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Nouveau regard sur la physiopathologie de l’hypertension artérielle pulmonaire

Jennifer Bordenave , Ly Tu , Laurent Savale , Alice Huertas , Marc Humbert et al.

Revue des Maladies Respiratoires, 2019, 36 (4), pp.433-437. ⟨10.1016/j.rmr.2019.03.003⟩

Article dans une revue inserm-02454990v1

Functional interaction between PDGFβ and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension

Marceau Quatredeniers , K Nakhleh Morad , J Dumas Sebastien , Audrey Courboulin , C Vinhas Maria et al.

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2019, 316 (3), pp.L445-L455. ⟨10.1152/ajplung.00537.2017⟩

Article dans une revue hal-02411597v1

Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator

Alice Huertas , Ly Tu , Marc Humbert , Christophe Guignabert

Cardiovascular Research, 2019, pp.cvz308. ⟨10.1093/cvr/cvz308⟩

Article dans une revue inserm-02454983v1

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases

Alice Huertas , Christophe Guignabert , Joan Barberà , Peter Bärtsch , Jahar Bhattacharya et al.

European Respiratory Journal, 2018, 51 (4), pp.1700745. ⟨10.1183/13993003.00745-2017⟩

Article dans une revue hal-04526502v1
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Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension

Paul-Benoit Poble , Carole Phan , Timothée Quatremare , Jennifer Bordenave , Raphaël Thuillet et al.

FASEB Journal, 2018, 33 (3), pp.3670-3679. ⟨10.1096/fj.201801659R⟩

Article dans une revue inserm-02581079v1

ACE2 as therapy for pulmonary arterial hypertension: the good outweighs the bad

Christophe Guignabert , Frances S de Man , Marc M. Lombès

European Respiratory Journal, 2018, 51 (6), pp.1800848. ⟨10.1183/13993003.00848-2018⟩

Article dans une revue inserm-02582393v1

Design, Synthesis, and Biological Activity of New N -(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension

Morane Le Hiress , Bernardin Akagah , Guillaume Bernadat , Ly Tu , Raphaël Thuillet et al.

Journal of Medicinal Chemistry, 2018, 61 (7), pp.2725-2736. ⟨10.1021/acs.jmedchem.7b01312⟩

Article dans une revue inserm-02580381v1
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Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis

Sven Günther , Jennifer Bordenave , Thông Hua-Huy , Carole Nicco , Amélie Cumont et al.

International Journal of Molecular Sciences, 2018, 19 (12), pp.4105. ⟨10.3390/ijms19124105⟩

Article dans une revue inserm-02612651v1
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Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

Tinne Mertens , Ankit Hanmandlu , Ly Tu , Carole Phan , Scott Collum et al.

Frontiers in Physiology, 2018, 9, pp.555. ⟨10.3389/fphys.2018.00555⟩

Article dans une revue inserm-02580921v1

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

Yuichi Tamura , Carole Phan , Ly Tu , Morane Le Hiress , Raphaël Thuillet et al.

Journal of Clinical Investigation, 2018, 128 (5), pp.1956-1970. ⟨10.1172/JCI96462⟩

Article dans une revue inserm-02580448v1

Pharmacovigilance in a rare disease: example of the VIGIAPATH program in pulmonary arterial hypertension

Marie-Camille Chaumais , Caroline O’connell , Laurent Savale , Christophe Guignabert , Frédéric Perros et al.

International Journal of Clinical Pharmacy, 2018, 40 (4), pp.790-794. ⟨10.1007/s11096-018-0712-y⟩

Article dans une revue hal-04526544v1

Dasatinib increases endothelial permeability leading to pleural effusion

Carole Phan , Etienne-Marie Jutant , Ly Tu , Raphaël Thuillet , Andrei Seferian et al.

European Respiratory Journal, 2018, 51 (1), pp.1701096. ⟨10.1183/13993003.01096-2017⟩

Article dans une revue inserm-02580192v1
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[IL6R is the key therapeutical target in pulmonary arterial hypertension]

Ly Tu , Carole Phan , Marc Humbert , Christophe Guignabert

Médecine/Sciences, 2018, 34 (10), pp.765-768. ⟨10.1051/medsci/2018201⟩

Article dans une revue inserm-02580983v1

Optimising experimental research in respiratory diseases: an ERS statement

Philippe Bonniaud , Aurélie Fabre , Nelly Frossard , Christophe Guignabert , Mark Inman et al.

European Respiratory Journal, 2018, 51 (5), pp.1702133. ⟨10.1183/13993003.02133-2017⟩

Article dans une revue hal-01996906v1
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Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension

Alice Huertas , Carole Phan , Jennifer Bordenave , Ly Tu , Raphaël Thuillet et al.

Chest, 2016, 149 (6), pp.1482-1493. ⟨10.1016/j.chest.2016.01.004⟩

Article dans une revue inserm-02593143v1

Vers de nouvelles cibles pour le traitement de l’hypertension artérielle pulmonaire : Importance des communications cellulaires

Ly Tu , Maria-Rosa Ghigna , Carole Phan , Jennifer Bordenave , Morane Le Hiress et al.

Biologie Aujourd'hui, 2016, 210 (2), pp.65-78. ⟨10.1051/jbio/2016010⟩

Article dans une revue inserm-02579962v1

Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

Christophe Guignabert , Carole Phan , Andrei Seferian , Alice Huertas , Ly Tu et al.

Journal of Clinical Investigation, 2016, 126 (9), pp.3207-3218. ⟨10.1172/JCI86249⟩

Article dans une revue inserm-02579754v1

Telomere Maintenance Is a Critical Determinant in the Physiopathology of Pulmonary Hypertension

Mohamed Izikki , Eric Hoang , Irena Draskovic , Olaf Mercier , Florence Lecerf et al.

Journal of the American College of Cardiology, 2015, 66 (17), pp.1942 - 1943. ⟨10.1016/j.jacc.2015.08.869⟩

Article dans une revue hal-01764142v1

Leptin signalling system as a target for pulmonary arterial hypertension therapy

Alice Huertas , Ly Tu , Raphaël Thuillet , Morane Le Hiress , Carole Phan et al.

European Respiratory Journal, 2015, 45 (4), pp.1066-1080. ⟨10.1183/09031936.00193014⟩

Article dans une revue inserm-02579431v1
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Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex

Morane Le Hiress , Ly Tu , Nicolas Ricard , Carole Phan , Raphaël Thuillet et al.

American Journal of Respiratory and Critical Care Medicine, 2015, 192 (8), pp.983-997. ⟨10.1164/rccm.201402-0322OC⟩

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Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension

Véronique Freund-Michel , Marcelina Cardoso dos Santos , Christophe Guignabert , David Montani , Carole Phan et al.

American Journal of Respiratory and Critical Care Medicine, 2015, 192, pp.342 - 355. ⟨10.1164/rccm.201410-1851oc⟩

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Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension

Véronique Freund-Michel , Marcelina Cardoso dos Santos , Christophe Guignabert , David Montani , Carole Phan et al.

American Journal of Respiratory and Critical Care Medicine, 2015, 192 (3), pp.342-355. ⟨10.1164/rccm.201410-1851OC⟩

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Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension

Marie-Camille Chaumais , Christophe Guignabert , Laurent Savale , Xavier Jaïs , Athénaïs Boucly et al.

American Journal of Cardiovascular Drugs, 2015, 15 (1), pp.13-26. ⟨10.1007/s40256-014-0095-y⟩

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Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension

Nicolas Ricard , Ly Tu , Morane Le Hiress , Alice Huertas , Carole Phan et al.

Circulation, 2014, 129 (15), pp.1586-1597. ⟨10.1161/CIRCULATIONAHA.113.007469⟩

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Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

Marine Germain , Mélanie Eyries , David Montani , Odette Poirier , Barbara Girerd et al.

Nature Genetics, 2013, 45 (5), pp.518-521. ⟨10.1038/ng.2581⟩

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Pulmonary arterial hypertension in patients treated by dasatinib.

David Montani , Emmanuel Bergot , Sven Günther , Laurent Savale , Anne Bergeron et al.

Circulation, 2012, 125 (17), pp.2128-37. ⟨10.1161/CIRCULATIONAHA.111.079921⟩

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Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension.

Alice Huertas , Ly Tu , Natalia Gambaryan , Barbara Girerd , Frédéric Perros et al.

European Respiratory Journal, 2012, 40 (4), pp.895-904. ⟨10.1183/09031936.00159911⟩

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A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.

Ly Tu , Frances S. de Man , Barbara Girerd , Alice Huertas , Marie-Camille Chaumais et al.

American Journal of Respiratory and Critical Care Medicine, 2012, 186 (7), pp.666-76. ⟨10.1164/rccm.201202-0309OC⟩

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Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.

Frances S. de Man , Ly Tu , Louis Handoko , Silvia Rain , Gerrina Ruiter et al.

American Journal of Respiratory and Critical Care Medicine, 2012, 186 (8), pp.780-9. ⟨10.1164/rccm.201203-0411OC⟩

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Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension.

Ly Tu , Laurence Dewachter , Benoit Gore , Elie Fadel , Philippe Dartevelle et al.

American Journal of Respiratory Cell and Molecular Biology, 2011, 45 (2), pp.311-22. ⟨10.1165/rcmb.2010-0317OC⟩

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Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension.

Laurence Dewachter , Serge Adnot , Christophe Guignabert , Ly Tu , Elisabeth Marcos et al.

European Respiratory Journal, 2009, 34 (5), pp.1100-10. ⟨10.1183/09031936.00183008⟩

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Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

Christophe Guignabert , Ly Tu , Mohamed Izikki , Laurence Dewachter , Patricia Zadigue et al.

FASEB Journal, 2009, 23 (12), pp.4135-47. ⟨10.1096/fj.09-131664⟩

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Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents.

Mohamed Izikki , Christophe Guignabert , Elie Fadel , Marc Humbert , Ly Tu et al.

Journal of Clinical Investigation, 2009, 119 (3), pp.512-23. ⟨10.1172/JCI35070⟩

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Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

Christophe Guignabert , Cristina Alvira , Tero-Pekka Alastalo , Hirofumi Sawada , Georg Hansmann et al.

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2009, 297 (6), pp.L1082-90. ⟨10.1152/ajplung.00199.2009⟩

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Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension.

Christophe Guignabert , Mohamed Izikki , Ly Ieng Tu , Zhenlin Li , Patricia Zadigue et al.

Circulation Research, 2006, 98 (10), pp.1323-30. ⟨10.1161/01.RES.0000222546.45372.a0⟩

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Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing.

François Maquerlot , Stéphane D. Galiacy , Michel Malo , Christophe Guignabert , Daniel A. Lawrence et al.

American Journal of Pathology, 2006, 169 (5), pp.1624-32

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Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.

Christophe Guignabert , Bernadette Raffestin , Rima Benferhat , William Raoul , Patricia Zadigue et al.

Circulation, 2005, 111 (21), pp.2812-9. ⟨10.1161/CIRCULATIONAHA.104.524926⟩

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Effect of doxycycline on sulfur mustard-induced respiratory lesions in guinea pigs.

Christophe Guignabert , Laurent Taysse , Jean-Henri Calvet , Emmanuelle Planus , Séraphin Delamanche et al.

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2005, 289 (1), pp.L67-74. ⟨10.1152/ajplung.00475.2004⟩

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