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Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells
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IL ‐2‐related regulatory CD4 T‐cell deficiency leads to the development of lung fibrosis and vascular remodeling
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Smooth muscle Rac1 contributes to pulmonary hypertension Short running title: Role of Rac1 in pulmonary hypertension
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Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension
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France Dierick
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Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort
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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation
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Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling
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The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy
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Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10
Claire Bouvard
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Cibler les ligands du récepteur de l’activine de type IIA pour traiter l’hypertension artérielle pulmonaire
Marc Humbert
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Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10
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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation
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Barbara Girerd
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Xavier Jaïs
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Pierantonio Laveneziana
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Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension
Laurent Savale
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Ly Tu
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Amélie Cumont
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Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension
Jennifer Bordenave
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Ly Tu
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Nihel Berrebeh
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Raphaël Thuillet
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Targeting Transforming Growth Factor Beta Receptors in Pulmonary Hypertension
Christophe Guignabert
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Connexin 43 Is a Promising Target for Pulmonary Hypertension due To Hypoxemic Lung Disease
Claire Bouvard
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Nafiisha Genet
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Multiple roles of macrophage migration inhibitory factor in pulmonary hypertension
Gael Jalce
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Christophe Guignabert
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Dendritic Cells in Pulmonary Hypertension: Foot Soldiers or Hidden Enemies?
Christophe Guignabert
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Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension
Zongye Cai
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Theo Klein
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Laurie Geenen
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Ly Tu
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Siyu Tian
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Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension
Marie-Camille Chaumais
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Amélie Cumont
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Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
Marc Humbert
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Sébastien Bonnet
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James Klinger
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Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling
Kondababu Kurakula
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Xiao-Qing Sun
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Chris Happé
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Denielli da Silva Goncalves Bos
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Robert Szulcek
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Journal articles
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Functional interaction between PDGFβ and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension
Marceau Quatredeniers
,
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,
J Dumas Sebastien
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Audrey Courboulin
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C Vinhas Maria
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Journal articles
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Nouveau regard sur la physiopathologie de l’hypertension artérielle pulmonaire
Jennifer Bordenave
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Ly Tu
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Alice Huertas
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Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure
Edda Spiekerkoetter
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Elena Goncharova
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Christophe Guignabert
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Kurt Stenmark
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Grazyna Kwapiszewska
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Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat
Jennifer Bordenave
,
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Ly Tu
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Carole Phan
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Amélie Cumont
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Journal articles
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Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator
Alice Huertas
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Ly Tu
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Marc Humbert
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Christophe Guignabert
Journal articles
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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension
Ly Tu
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Agnes Desroches-Castan
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Christine Mallet
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Laurent Guyon
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Amélie Cumont
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Circulation Research, 2019
Journal articles
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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension
Ly Tu
,
Agnes Desroches-Castan
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Christine Mallet
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Laurent Guyon
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Amélie Cumont
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Journal articles
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Dasatinib increases endothelial permeability leading to pleural effusion
Carole Phan
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Etienne-Marie Jutant
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Ly Tu
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Raphaël Thuillet
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Andrei Seferian
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Journal articles
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Design, Synthesis, and Biological Activity of New N -(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension
Morane Le Hiress
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Guillaume Bernadat
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Ly Tu
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ACE2 as therapy for pulmonary arterial hypertension: the good outweighs the bad
Christophe Guignabert
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Frances S de Man
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Marc M. Lombès
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Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension
Paul-Benoit Poble
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Carole Phan
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Timothée Quatremare
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Jennifer Bordenave
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Journal articles
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Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension
Yuichi Tamura
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Carole Phan
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Ly Tu
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Morane Le Hiress
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Raphaël Thuillet
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Journal articles
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Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension
Tinne Mertens
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Ankit Hanmandlu
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Ly Tu
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Carole Phan
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Scott Collum
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Journal articles
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Optimising experimental research in respiratory diseases: an ERS statement
Philippe Bonniaud
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Aurélie Fabre
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Nelly Frossard
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Christophe Guignabert
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Mark Inman
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[IL6R is the key therapeutical target in pulmonary arterial hypertension]
Ly Tu
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Carole Phan
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Marc Humbert
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Christophe Guignabert
Journal articles
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Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis
Sven Günther
,
Jennifer Bordenave
,
Thông Hua-Huy
,
Carole Nicco
,
Amélie Cumont
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Journal articles
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|
Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension
Alice Huertas
,
Carole Phan
,
Jennifer Bordenave
,
Ly Tu
,
Raphaël Thuillet
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Journal articles
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Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension
Christophe Guignabert
,
Carole Phan
,
Andrei Seferian
,
Alice Huertas
,
Ly Tu
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Journal articles
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Vers de nouvelles cibles pour le traitement de l’hypertension artérielle pulmonaire : Importance des communications cellulaires
Ly Tu
,
Maria-Rosa Ghigna
,
Carole Phan
,
Jennifer Bordenave
,
Morane Le Hiress
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Journal articles
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Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex
Morane Le Hiress
,
Ly Tu
,
Nicolas Ricard
,
Carole Phan
,
Raphaël Thuillet
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Journal articles
inserm-02579320v1
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Leptin signalling system as a target for pulmonary arterial hypertension therapy
Alice Huertas
,
Ly Tu
,
Raphaël Thuillet
,
Morane Le Hiress
,
Carole Phan
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Journal articles
inserm-02579431v1
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|
Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension
Véronique Freund-Michel
,
Marcelina Cardoso dos Santos
,
Christophe Guignabert
,
David Montani
,
Carole Phan
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Journal articles
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Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension
Véronique Freund-Michel
,
Marcelina Cardoso dos Santos
,
Christophe Guignabert
,
David Montani
,
Carole Phan
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Journal articles
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|
Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension
Marie-Camille Chaumais
,
Christophe Guignabert
,
Laurent Savale
,
Xavier Jaïs
,
Athénaïs Boucly
et al.
Journal articles
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|
Telomere Maintenance Is a Critical Determinant in the Physiopathology of Pulmonary Hypertension
Mohamed Izikki
,
Eric Hoang
,
Irena Draskovic
,
Olaf Mercier
,
Florence Lecerf
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Journal articles
hal-01764142v1
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Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension
Nicolas Ricard
,
Ly Tu
,
Morane Le Hiress
,
Alice Huertas
,
Carole Phan
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Journal articles
inserm-02578269v1
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|
Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension
Marine Germain
,
Mélanie Eyries
,
David Montani
,
Odette Poirier
,
Barbara Girerd
et al.
Journal articles
hal-02565627v1
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|
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.
Frances S. de Man
,
Ly Tu
,
Louis Handoko
,
Silvia Rain
,
Gerrina Ruiter
et al.
Journal articles
inserm-00905193v1
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|
Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension.
Alice Huertas
,
Ly Tu
,
Natalia Gambaryan
,
Barbara Girerd
,
Frédéric Perros
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Journal articles
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Pulmonary arterial hypertension in patients treated by dasatinib.
David Montani
,
Emmanuel Bergot
,
Sven Günther
,
Laurent Savale
,
Anne Bergeron
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Journal articles
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|
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.
Ly Tu
,
Frances S. de Man
,
Barbara Girerd
,
Alice Huertas
,
Marie-Camille Chaumais
et al.
Journal articles
inserm-00905191v1
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|
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension.
Ly Tu
,
Laurence Dewachter
,
Benoit Gore
,
Elie Fadel
,
Philippe Dartevelle
et al.
Journal articles
inserm-00579959v1
|
|
Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.
Christophe Guignabert
,
Ly Tu
,
Mohamed Izikki
,
Laurence Dewachter
,
Patricia Zadigue
et al.
Journal articles
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|
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.
Christophe Guignabert
,
Cristina Alvira
,
Tero-Pekka Alastalo
,
Hirofumi Sawada
,
Georg Hansmann
et al.
Journal articles
inserm-00499633v1
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|
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents.
Mohamed Izikki
,
Christophe Guignabert
,
Elie Fadel
,
Marc Humbert
,
Ly Tu
et al.
Journal articles
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|
Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension.
Laurence Dewachter
,
Serge Adnot
,
Christophe Guignabert
,
Ly Tu
,
Elisabeth Marcos
et al.
Journal articles
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|
Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension.
Christophe Guignabert
,
Mohamed Izikki
,
Ly Ieng Tu
,
Zhenlin Li
,
Patricia Zadigue
et al.
Journal articles
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Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing.
François Maquerlot
,
Stéphane D. Galiacy
,
Michel Malo
,
Christophe Guignabert
,
Daniel A. Lawrence
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American Journal of Pathology, 2006, 169 (5), pp.1624-32
Journal articles
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Effect of doxycycline on sulfur mustard-induced respiratory lesions in guinea pigs.
Christophe Guignabert
,
Laurent Taysse
,
Jean-Henri Calvet
,
Emmanuelle Planus
,
Séraphin Delamanche
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Journal articles
inserm-00499644v1
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|
Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.
Christophe Guignabert
,
Bernadette Raffestin
,
Rima Benferhat
,
William Raoul
,
Patricia Zadigue
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Journal articles
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|