DF

Dimitri Fayolle

10
Documents
Affiliations actuelles
  • Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN)
  • Université de Caen Normandie - UFR Santé (UNICAEN Santé)
Identifiants chercheurs

Présentation

Dr Dimitri Fayolle is a physical chemist applying analytical tools to drug discovery, mostly through the determination of druggability parameters. He is a Research Engineer and the principal scientist of the Drug Innovation and Design platform (DruiD) at the CERMN laboratory (University of Caen, FR).

After a BSc in physical chemistry (2015, Montpellier, FR) and a MSc in organic synthesis (2017, Lyon, FR), he defended in 2020 a PhD thesis in bioorganic chemistry under the supervision of Prof. Peter Strazewski in Lyon, FR, studying the formation of complex mixtures of small amphiphilic biomolecules under conditions mimicking the origins of life, and the anchoring of such molecules to cell-like membranes. A large part of this research revolved around LC/MS and liquid-state NMR.

He was then recruited in early 2022 as a postdoctoral researcher in magnetic resonance at the University of Caen, developing new technologies for 129Xe magnetic resonance imaging in preclinical research, before becoming a permanent Research Engineer at the CERMN laboratory of the University of Caen in 2023. He is now in charge of the newly-founded Drug Innovation and Design platform of the lab. The platform offers its expertise in medicinal chemistry, biological activity screeining (enzymology, receptor binding...), drugability profiling (solubility, lipophilicity, permeation) and galenics, and is open to collaboration with academics and pharmaceutical companies. Dr Fayolle's research currently focuses on the determination of the lipophilicity of drugs, including emergent classes such as macromolecules.

Domaines de recherche

Chimie analytique Chimie organique Chimie thérapeutique Médicaments

Compétences

Druggability HPLC NMR ITC Mass spectrometry

Publications

Publications

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Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

Omar Khoumeri , Sébastien Hutter , Nicolas Primas , Caroline Castera-Ducros , Sandra Carvalho et al.
Pharmaceuticals, 2024, 17 (7), pp.878. ⟨10.3390/ph17070878⟩
Article dans une revue hal-04635068 v1
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A biomimetic multiparametric assay to characterise anti-amyloid drugs

Willy Smeralda , Marc Since , Sophie Corvaisier , Dimitri Fayoll , Julien Cardin et al.
International Journal of Molecular Sciences, 2023, 24 (23), pp.16982. ⟨10.3390/ijms242316982⟩
Article dans une revue hal-04315267 v1
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Synthesis of phospholipids under plausible prebiotic conditions and analogies with phospholipid biochemistry or origin of life studies

Michele Fiore , Carolina Chieffo , Augustin Lopez , Dimitri Fayolle , Johal Ruiz et al.
Astrobiology, In press, ⟨10.1089/ast.2021.0059⟩
Article dans une revue hal-03591985 v1

Synthesis and Physicochemical Properties of Cryptophazane—A Soluble and Functionalizable C 1 ‐Symmetrical Cryptophane

Clément Vigier , Dimitri Fayolle , Hussein El Siblani , Jana Sopkova - de Oliveira Santos , Frederic Fabis et al.
Angewandte Chemie, 2022, 134 (46), ⟨10.1002/ange.202208580⟩
Article dans une revue hal-03854418 v1

Racemic Phospholipids for Origin of Life Studies

Emiliano Altamura , Arnaud Comte , Alice D’onofrio , Charlotte Roussillon , Dimitri Fayolle et al.
Symmetry, 2020, 12 (7), pp.1108. ⟨10.3390/sym12071108⟩
Article dans une revue hal-04939086 v1
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Chemical Analysis of Lipid Boundaries after Consecutive Growth and Division of Supported Giant Vesicles

Augustin Lopez , Dimitri Fayolle , Michele Fiore , Peter Strazewski
iScience, 2020, 23, pp.101677 -. ⟨10.1016/j.isci.2020.101677⟩
Article dans une revue hal-03493161 v1
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Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside

Dimitri Fayolle , Nathalie Berthet , Bastien Doumèche , Olivier Renaudet , Peter Strazewski et al.
Beilstein Journal of Organic Chemistry, 2019, 15, pp.937-946. ⟨10.3762/bjoc.15.90⟩
Article dans une revue hal-02120795 v1

Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside

Dimitri Fayolle , Nathalie Berthet , Bastien Doumeche , Olivier Renaudet , Peter Strazewski et al.
Beilstein Journal of Organic Chemistry, 2019, 15, pp.937-946. ⟨10.3762/bjoc.15.90⟩
Article dans une revue hal-04975190 v1

Rapid purification of giant lipid vesicles by microfiltration

Dimitri Fayolle , Michele Fiore , Pasquale Stano , Peter Strazewski , Peter Butko
PLoS ONE, 2018, 13 (2), pp.e0192975. ⟨10.1371/journal.pone.0192975⟩
Article dans une revue hal-02121315 v1
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Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments

Dimitri Fayolle , Emiliano Altamura , Alice d'Onofrio , Warren Madanamothoo , Bernard Fenet et al.
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-18053-y⟩
Article dans une revue hal-02122490 v1