Emeline Nandrot

Chef d'Equipe, CR1 CNRS, Institut de la Vision, Paris, France
41
Documents
Affiliations actuelles
  • Centre National de la Recherche Scientifique (CNRS)
  • Institut des sciences biologiques - CNRS Biologie (INSB-CNRS)
  • Sorbonne Université (SU)
  • Institut National de la Santé et de la Recherche Médicale (INSERM)
Identifiants chercheurs
Contact

Domaines de recherche

Organes des sens Biochimie, Biologie Moléculaire Biologie cellulaire

Publications

Publications

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Retinal atrophy, inflammation, phagocytic and metabolic disruptions develop in the MerTK-cleavage-resistant mouse model

Julie Enderlin , Quentin Rieu , Salomé Réty , Elora M Vanoni , Solène Roux et al.
Frontiers in Neuroscience, 2024, 18, ⟨10.3389/fnins.2024.1256522⟩
Article dans une revue hal-04563541 v1
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Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic Activity Required for Circadian Retinal Phagocytosis

Célia Parinot , Jonathan Chatagnon , Quentin Rieu , Solène Roux , Dorine Néel et al.
International Journal of Molecular Sciences, 2024, 25 (12), pp.6630. ⟨10.3390/ijms25126630⟩
Article dans une revue inserm-04799289 v1
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Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration. Ablation of primary cilia exclusively in the RPE leads to retinal degeneration and visual impairment

Viola Kretschmer , Sandra Schneider , Peter A. Matthiessen , Dominik Reichert , Nathan Hotaling et al.
PLoS Biology, In press, 21 (12), pp.e3002402. ⟨10.1371/journal.pbio.3002402⟩
Article dans une revue inserm-04292959 v1
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Pleiotropic Roles of Scavenger Receptors in Circadian Retinal Phagocytosis: A New Function for Lysosomal SR-B2/LIMP-2 at the RPE Cell Surface

Quentin Rieu , Antoine Bougoüin , Yvrick Zagar , Jonathan Chatagnon , Abdallah Hamieh et al.
International Journal of Molecular Sciences, 2022, 23 (7), pp.3445. ⟨10.3390/ijms23073445⟩
Article dans une revue inserm-03814298 v1
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Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue

Amélie Rodrigues , Amélie Slembrouck-Brec , Céline Nanteau , Angélique Terray , Yelyzaveta Tymoshenko et al.
NPJ Regenerative medicine, 2022, 7, pp.39. ⟨10.1038/s41536-022-00235-6⟩
Article dans une revue hal-03774125 v1
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Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction

Francesca Mazzoni , Ying Dun , Jade A Vargas , Emeline Nandrot , Silvia C Finnemann
Redox Biology, 2021, pp.101918. ⟨10.1016/j.redox.2021.101918⟩
Article dans une revue hal-03163479 v1
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A Splice Variant in SLC16A8 Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells

Laurence Klipfel , Marie Cordonnier , Léa Thiébault , Emmanuelle Clérin , Frédéric Blond et al.
Cells, 2021, 10 (1), pp.179. ⟨10.3390/cells10010179⟩
Article dans une revue hal-03131049 v1
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Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells

Alvaro Plaza Reyes , Sandra Petrus-Reurer , Sara Padrell Sánchez , Pankaj Kumar , Iyadh Douagi et al.
Nature Communications, 2020, 11 (1), pp.1609. ⟨10.1038/s41467-020-15326-5⟩
Article dans une revue inserm-02648422 v2
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Preclinical safety studies of human embryonic stem cell‐derived retinal pigment epithelial cells for the treatment of age‐related macular degeneration

Sandra Petrus-Reurer , Pankaj Kumar , Sara Padrell Sánchez , Monica Aronsson , Helder André et al.
Stem Cells Translational Medicine, 2020, 9, pp.936 - 953. ⟨10.1002/sctm.19-0396⟩
Article dans une revue hal-03086697 v1
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Cohen Syndrome-Associated Cataract Is Explained by VPS13B Functions in Lens Homeostasis and Is Modified by Additional Genetic Factors

Vincent Lhussiez , Elisabeth Dubus , Quénol Cesar , Niyazi Acar , Emeline F Nandrot et al.
Investigative Ophthalmology & Visual Science, 2020, 61 (11), pp.18. ⟨10.1167/iovs.61.11.18⟩
Article dans une revue hal-02969762 v1
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Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

Sara Touhami , Fanny Beguier , Sébastien Augustin , Hugo Charles-Messance , Lucile Vignaud et al.
Journal of Neuroinflammation, 2018, 15 (1), pp.85. ⟨10.1186/s12974-018-1106-8⟩
Article dans une revue inserm-01736588 v1
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Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production

Xia Dong , Weiju Wu , Liang Ma , Chengfei Liu , Mohajeet B Bhuckory et al.
Journal of Innate Immunity, 2017, 9, pp.529 - 545. ⟨10.1159/000478042⟩
Article dans une revue hal-03086718 v1
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Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions

Sacha Reichman , Amélie Slembrouck , Giuliana Gagliardi , Antoine Chaffiol , Angélique Terray et al.
STEM CELLS, 2017, ⟨10.1002/stem.2586⟩
Article dans une revue hal-01480587 v1
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Otx2- genetically modified retinal pigment epithelial cells rescue photoreceptors after transplantation

Christo Kole , Laurence Klipfel , Ying Yang , Vanessa Ferracane , Frédéric Blond et al.
Molecular Therapy, 2017, ⟨10.1016/j.ymthe.2017.09.007⟩
Article dans une revue hal-01611959 v1
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Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis

Ah-Lai Law , Célia Parinot , Jonathan Chatagnon , Basile Gravez , José-Alain Sahel et al.
Journal of Biological Chemistry, 2015, 290 (8), pp.4941-4952. ⟨10.1074/jbc.M114.628297⟩
Article dans une revue hal-03086745 v1
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From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium

Sacha Reichman , Angélique Terray , Amélie Slembrouck , Céline Nanteau , Gaël Orieux et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111, pp.8518 - 8523. ⟨10.1073/pnas.1324212111⟩
Article dans une revue hal-03086749 v1
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Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells

Célia Parinot , Quentin Rieu , Jonathan Chatagnon , Silvia C. Finnemann , Emeline F. Nandrot
Journal of visualized experiments : JoVE, 2014
Article dans une revue hal-03086746 v1
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Mutations in Pre-mRNA Processing Factors 3, 8, and 31 Cause Dysfunction of the Retinal Pigment Epithelium

Michael H Farkas , Deborah S Lew , Maria E Sousa , Kinga Bujakowska , Jonathan Chatagnon et al.
American Journal of Pathology, 2014, 184, pp.2641 - 2652. ⟨10.1016/j.ajpath.2014.06.026⟩
Article dans une revue hal-03086747 v1
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CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.

Florian Sennlaub , Constance Auvynet , Bertrand Calippe , Sophie Lavalette , Lucie Poupel et al.
EMBO Molecular Medicine, 2013, 5 (11), pp.1775-93. ⟨10.1002/emmm.201302692⟩
Article dans une revue inserm-00912837 v1
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Disease-Causing Mutations in BEST1 Gene Are Associated with Altered Sorting of Bestrophin-1 Protein

Jordan A. Doumanov , Christina Zeitz , Paloma Dominguez Gimenez , Isabelle Audo , Abhay Krishna et al.
International Journal of Molecular Sciences, 2013, 14 (7), pp.15121-15140. ⟨10.3390/ijms140715121⟩
Article dans une revue hal-01583466 v1
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Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin

Emeline Nandrot , Kathryn E Silva , Christina Scelfo , Silvia C Finnemann
Biology of the Cell, 2012, 104, pp.326 - 341. ⟨10.1111/boc.201100076⟩
Article dans une revue hal-03086754 v1
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The Signalling Role of the αvβ5-Integrin Can Impact the Efficacy of AAV in Retinal Gene Therapy

Thérèse Cronin , Daniel Chung , Ying Yang , Emeline Nandrot , Jean Bennett
Pharmaceuticals, 2012, 5 (5), pp.447 - 459. ⟨10.3390/ph5050447⟩
Article dans une revue inserm-02894109 v1
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Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin

Chia-Chia Yu , Emeline Nandrot , Ying Dun , Silvia C Finnemann
Free Radical Biology and Medicine, 2011, 52, pp.660 - 670. ⟨10.1016/j.freeradbiomed.2011.11.021⟩
Article dans une revue hal-03086755 v1
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Three Gene-Targeted Mouse Models of RNA Splicing Factor RP Show Late-Onset RPE and Retinal Degeneration

John J. Graziotto , Michael Farkas , Kinga Bujakowska , Bertrand M. Deramaudt , Qi Zhang et al.
Investigative Ophthalmology & Visual Science, 2011
Article dans une revue hal-03086760 v1
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In vitro differentiation of retinal pigment epithelium from adult retinal stem cells

Claudia Aruta , Francesca Giordano , Anna de Marzo , Antonella Comitato , Graça Raposo et al.
Pigment Cell & melanoma research, 2010, 24 (1), pp.233 - 240. ⟨10.1111/j.1755-148x.2010.00793.x⟩
Article dans une revue istex hal-03086757 v1
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EYS is a major gene for rod-cone dystrophies in France

Isabelle Audo , José-Alain Sahel , Saddek Mohand-Saïd , Marie-Elise Lancelot , Aline Antonio et al.
Human Mutation, 2010, 31 (5), ⟨10.1002/humu.21249⟩
Article dans une revue hal-00552377 v1
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TRPM1 Is Mutated in Patients with Autosomal-Recessive Complete Congenital Stationary Night Blindness

Isabelle Audo , Susanne Kohl , Bart P Leroy , Francis L Munier , Xavier Guillonneau et al.
American Journal of Human Genetics, 2009, 85, pp.720 - 729. ⟨10.1016/j.ajhg.2009.10.013⟩
Article dans une revue hal-03086762 v1
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Lack of v 5 Integrin Receptor or Its Ligand MFG-E8: Distinct Effects on Retinal Function

Emeline F. Nandrot , Silvia C. Finnemann
Ophthalmic Research, 2008
Article dans une revue hal-03086766 v1
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Essential role for MFG-E8 as ligand for ␣v␤5 integrin in diurnal retinal phagocytosis

Emeline Nandrot , Monika Anand , Dena Almeida , Kamran Atabai , Dean Sheppard et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007
Article dans une revue hal-03086772 v1
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Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak

Emeline F. Nandrot , Monika Anand , Mousumi Sircar , Silvia C. Finnemann
American Journal of Physiology - Cell Physiology, 2006
Article dans une revue hal-03086780 v1
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Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter.

Alexis-Pierre Bemelmans , Sébastien Bonnel , Leila Houhou , Noëlle Dufour , Emeline Nandrot et al.
The Journal of Gene Medicine, 2005, 7 (10), pp.1367-1374. ⟨10.1002/jgm.788⟩
Article dans une revue hal-00187439 v1
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Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking alphavbeta5 Integrin

Emeline F. Nandrot , Yoonhee Kim , Scott E. Brodie , Xiaozhu Huang , Dean Sheppard et al.
Journal of Experimental Medicine, 2004
Article dans une revue hal-03086798 v1
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Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degeneration

Eric M. Dufour , Emeline Nandrot , Dominique Marchant , Loic van den Berghe , Stéphanie Gadin et al.
Neurobiology of Disease, 2003, pp.166-180
Article dans une revue hal-03086809 v1
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Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts

Emeline Nandrot , Christine Slingsby , A Basak , M Cherif-Chefchaouni , B Benazzouz et al.
Journal of Medical Genetics, 2003
Article dans une revue hal-03086814 v1
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Evidence of clinical and genetic heterogeneity in autosomal dominant congenital cerulean cataracts

Latifa Hilal , Emeline Nandrot , Mohamed Belmekki , Siham El Bacha , Mohamed Chefchaouni et al.
Ophthalmic Genetics, 2002
Article dans une revue hal-03086816 v1
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Homozygous Deletion in the Coding Sequence of the c-mer Gene in RCS Rats Unravels General Mechanisms of Physiological Cell Adhesion and Apoptosis

Emeline Nandrot , Eric Dufour , Alexandra C Provost , Marie O Péquignot , Sébastien Bonnel et al.
Neurobiology of Disease, 2000, 7, pp.586 - 599. ⟨10.1006/nbdi.2000.0328⟩
Article dans une revue istex hal-03086817 v1
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The Retinal Pigment Epithelium: Cells That Know the Beat!

Elora M Vanoni , Emeline F Nandrot
Retinal Degenerative Diseases XIX, 1415, Springer International Publishing, pp.539-545, 2023, Advances in Experimental Medicine and Biology, 978-3-031-27680-4. ⟨10.1007/978-3-031-27681-1_79⟩
Chapitre d'ouvrage inserm-04313839 v1

Retinal pigment epithelial cells: the unveiled component in the etiology of Prpf splicing factor-associated retinitis pigmentosa

Abdallah Hamieh , Emeline F. Nandrot
Advances in Experimental Medicine and Biology, 1185, Springer International Publishing AG, pp.227-231, 2019, Retinal Degenerative Diseases - Mechanisms and Experimental Therapy
Chapitre d'ouvrage hal-02408306 v1

Retinal pigment epithelial cells: super phagocytes with a rhythm

Abdallah Hamieh , Emeline F. Nandrot
Cell Biology Research Progress, "Phagocytosis: Overview, History and Role in Human Health and Disease", 2018
Chapitre d'ouvrage hal-02408266 v1

Opposite roles of MerTK ligands Gas6 and Protein S during retinal phagocytosis

Emeline F. Nandrot
Advances in Experimental Medicine and Biology, 1074, Springer International Publishing AG, pp.577-583, 2018, Retinal Degenerative Diseases
Chapitre d'ouvrage hal-02408253 v1