EL

Ewen Lescop

117
Documents
Identifiants chercheurs

Présentation

Nuclear Magnetic Resonance (NMR) spectroscopy provides a wealth of information about the structure and dynamics of biomolecules in solution as well as of their complexes. As such, it highly contributes to our understanding of the molecular mechanisms that underly life. Such knowledge is fundamental not only for the general quest for a better understanding of nature but is also required for rational approaches in health or agronomy industry.

My research interests lie in the development of NMR methods, in particular to speed up NMR data collection and the application of NMR to understand the role of interdomain dynamics in the catalytic cycle of the human CPR, the role of heme orientation in the function of the hexacoordinated human neuroglobin and the structural and dynamics study of microcins and the TCTP cancer drug. More recently I started a research program about protein/lipid interactions with biomembrane with a new and original approach using high-pressure NMR.


Compétences

RMN; biochimie

Publications

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Publications

RMN multi-dimensionnelle et techniques rapides

Ewen Lescop , Guillaume Laurent , Patrick Giraudeau
Ecole du GERM 2024, Mar 2024, Cargese (Corse), France
Communication dans un congrès hal-04932630 v1

NMR Paramagnetic effects of lanthanide complexes under high hydrostatic pressure to probe the structure of proteins and contrast agents.

François Giraud , Anthony Potenza , Philippe Durand , Xu Dong , Wenxue Jiang et al.
Journées Scientifiques CENTRA, Association CENTRA, Feb 2024, Gif-sur-Yvette, France
Communication dans un congrès hal-04484744 v1

Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
22ème congrès du Groupe français des membranes (GEM), SFB/GEM, Mar 2023, Autrans, France
Communication dans un congrès hal-04396785 v1

Molecular bases of the specific recognition of tRNA by cyclodipeptide synthases: Use of RNA microhelices to mimick tRNA acceptor stem

Zahra Marouf , Paloma Fernandez Varela , Carine Tellier , Matthieu Glousieau , Nelly Morellet et al.
Journée ED ITFA, ED ITFA, Jun 2023, Orsay, France
Communication dans un congrès hal-04397018 v1

NMR to probe (bio)molecules-light interactions: application to fluorescent proteins?

Theo Beguin , Francois Giraud , Marie Erard , Hélène Pasquier , Ewen Lescop
LM@W 2023 symposium, LM@W, Oct 2023, Gif-sur-Yvette, France
Communication dans un congrès hal-04396805 v1

FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER.

Luce Dreno , Farès Ousalem , Besimé Celik , Carolina Tiraboschi , Yohann Loriot et al.
Congrès ARTP, ARTP, Nov 2023, Paris, France
Communication dans un congrès hal-04397195 v1

Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
Congrès BSI, AFC/SFB, Nov 2023, Marseille, France
Communication dans un congrès hal-04396783 v1

Do lipids and proteins affect each other's dynamics in biomembranes? Insights at atomic resolution from high-pressure NMR studies

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
journée plateforme RMN CEISAM, CEISAM, Jun 2023, Nantes, France
Communication dans un congrès hal-04396788 v1

Probing lipid/protein interactions under High-Pressure NMR

François Giraud , Alexandre Pozza , Quentin Cece , Marina Casiraghi , Elodie Point et al.
GERM 2023 Résonance Magnétique aux extrêmes, GERM, Jun 2023, Murol, France
Communication dans un congrès hal-04429995 v1

Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
GDR Protéine membranaire Appicom, GDR Protéine membranaire Appicom, Oct 2022, Dourdan, France
Communication dans un congrès hal-04396757 v1

Deciphering the interactions of Cyclodipeptide Synthases with their shortened tRNA substrates by NMR, X-ray crystallography and biophysical approaches

Zahra Marouf , Paloma Fernandez Varela , Carine Tellier , Matthieu Glousieau , Nelly Morellet et al.
Journée BSI@Paris-Saclay, Réseau BSI@Paris-Saclay, Nov 2022, Gif-sur-Yvette, France
Communication dans un congrès hal-04396986 v1

Exploration de l'interaction dynamique entre les lipides et les protéines membranaires par spectroscopie RMN à haute pression

François Giraud , Alexandre Pozza , Quentin Cece , Marina Casiraghi , Elodie Point et al.
13ème FORUM de technologies des HAUTES PRESSIONS, RESEAU HP, Jun 2022, Blériot-Plage, France
Communication dans un congrès hal-04429875 v1

Probing the coupled dynamics between lipids and membrane proteins in nanodiscs by high-pressure NMR spectroscopy

Alexandre Pozza , Francois Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
Journée utilisateurs Infranalytics, Infranalytics, Nov 2022, Marseille, France
Communication dans un congrès hal-04396762 v1

Binding of the Cancer-Related TCTP Protein to Mcl-1/Bcl-xL Requires and Triggers an Order-to-Disorder Transition to Make its BH3 Region Accessible

Florian Malard , Christina Sizun , Eric Jacquet , Aurélien Thureau , Ludovic Carlier et al.
Colloque Piramid, Piramid, Sep 2021, Nantes (44000), France
Communication dans un congrès hal-04396414 v1

TCTP is an anti-apoptotic protein containing a BH3-like motif

Florian Malard , Christina Sizun , Eric Jacquet , Aurélien Thureau , Ludovic Carlier et al.
ENC, ENC, Mar 2021, Online, United States
Communication dans un congrès hal-04396413 v1

FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER

Luce Dreno , Marine Garrido , Matthieu Bertrand , Sofia Calpe , Mariana Tannoury et al.
journée ED 582, ED582 Paris-Saclay, Nov 2021, Gif-sur-Yvette, France
Communication dans un congrès hal-04396931 v1

Atomic level description of the Binding of the Cancer-Related TCTP Protein to the sertraline drug and to the anti-apoptotic Mcl-1 protein

Florian Malard , Eric Jacquet , Naima Nhiri , Christina Sizun , Amélie Chabrier et al.
Biotechnocentre, Biotechnocentre, Oct 2021, Chaumont sur Tharonne, France
Communication dans un congrès hal-04396389 v1

Etude d'interactions lipides / protéines membranaires par RMN à haute pression

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
Journée HP "Biologie sous pression : développement de cellules et métrologie", Forum haute pression, Dec 2021, Paris, France
Communication dans un congrès hal-04396766 v1

REGULATION OF EIF4F TRANSLATION INITIATION COMPLEX BY THE PEPTIDYL PROLYL ISOMERASE FKBP7 IN TAXANE-RESISTANT PROSTATE CANCER

Luce Dreno , Marine Garrido , Mariana Tannoury , Matthieu Bertrand , Nadine Assrir et al.
2ème journée scientifique de l'institut de Recherche sur le Médicament et l'Innovation Thérapeutique, IRMIT, Dec 2020, Online, France
Communication dans un congrès hal-04396926 v1

Using NMR for the structural and kinetic characterization of peptide - liposome associations to support formulation design

Camille Doyen , Eric Larquet , Pierre-Damien Coureux , Oriane Frances , Frédéric Herman et al.
Réunion RMN Ile de France, Sep 2020, Gif-sur-Yvette, France
Communication dans un congrès hal-04396378 v1

Towards NMR characterization of apelin encapsulated in liposomes

Camille Doyen , Eric Larquet , Pierre-Damien Coureux , Oriane Frances , Frédéric Herman et al.
Réunion RMN@UPSAY, May 2019, Gif-sur-Yvette, France
Communication dans un congrès hal-04396367 v1

The molecular mechanism of the interaction between TCTP and the Bcl-2 proteins (Bcl-xL, Mcl-1) in the context of tumor reversion

Florian Malard , Christina Sizun , Eric Jacquet , Aurélien Thureau , Ludovic Carlier et al.
Congrès BSI, AFC/SFB, Nov 2019, Toulouse, France
Communication dans un congrès hal-04396359 v1

METHODES (RAPIDES) POUR DES ETUDES DE RMN SOUS PRESSION

Ewen Lescop
Congrès GERM, GERM, May 2019, Oléron, France
Communication dans un congrès hal-04396354 v1

A well-balanced preexisting equilibrium governs maximal electron flux efficiency of a multidomain diflavin reductase.

Oriane Frances , Fataneh Fatemi , Denis Pompon , Eric Guittet , Christina Sizun et al.
Asia-Pacific NMR conference, Jul 2019, Singapour, Singapore
Communication dans un congrès hal-04396350 v1

Deciphering at the atomic level the protein/protein interaction network between the cancer targets TCTP and Bcl-2 proteins Bcl-xL and Mcl-1 by NMR spectroscopy and other structural approaches.

Florian Malard , Christina Sizun , Eric Jacquet , Aurélien Thureau , Ludovic Carlier et al.
International cancer and ageing conference, HUST Wuhan, Oct 2019, Wuhan, China
Communication dans un congrès hal-04396348 v1

Pharmacology of tumor reversion at TCTP protein: interaction studies, limitation and future

Florian Malard , Christina Sizun , Eric Jacquet , Aurélien Thureau , Ludovic Carlier et al.
8eme Colloque Annuel du LabEx LERMIT, LERMIT, Nov 2019, Gif-sur-Yvette, France
Communication dans un congrès hal-04396325 v1

NMR spectroscopy: a powerful and essential tool for diagnosis, drug discovery and development

Ewen Lescop
Inauguration 800MHz Sanofi, Sanofi, Mar 2018, Vitry-sur-Seine, France
Communication dans un congrès hal-04396328 v1

Nuclear Magnetic Resonance (NMR) as a tool to probe the structure/DYNAMICS/function of proteins

Ewen Lescop
Convention on Innovative therapeutics for Cancer and Ageing diseases, Hust Wuhan, Oct 2018, Wuhan, China
Communication dans un congrès hal-04396339 v1

Redox and pH control of the human iron-sulfur repair protein MitoNEET activity via its iron-sulfur cluster.

Cecile Mons , Ioana Ferecatu , Sylvie Riquier , Ewen Lescop , Cécile Bouton et al.
ICMRBS, Aug 2018, Dublin (Ireland), Ireland
Communication dans un congrès hal-04396332 v1

Structural basis of the broad specificity of a general odorant-binding protein from honeybee

Ewen Lescop , Loïc Briand , J Claude Pernollet , Eric Guittet
34. Congress of the Federation of European Biochemical Societies, Jul 2009, Prague, Czech Republic. ⟨10.1021/bi802300k⟩
Communication dans un congrès hal-02758513 v1

FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER.

Luce Dreno , Farès Ousalem , Besimé Celik , Carolina Tiraboschi , Yohann Loriot et al.
Journées Jeunes Chercheurs ARC, Oct 2023, Paris, France
Poster de conférence hal-04397185 v1

Molecular basis of the specific recognition of tRNA substrates by cyclodipeptide synthases explored using RNA microhelices

Zahra Marouf , Paloma Fernandez Varela , Carine Tellier , Matthieu Glousieau , Pierre Legrand et al.
Congrès BSI, Nov 2023, Marseille, France
Poster de conférence hal-04397161 v1

Probing the coupled dynamics between lipids and membrane proteins by high-pressure NMR spectroscopy

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
Euromar, Jul 2022, Utrecht, Netherlands
Poster de conférence hal-04396751 v1

Structural and functional studies of cyclodipeptide synthases with RNA microhelices mimicking their tRNA susbtrates.

Zahra Marouf , Paloma Fernandez Varela , Carine Tellier , Matthieu Glousieau , Jérôme Séguin et al.
33ème édition de la Conférence Européenne de Cristallographie (ECM33), Aug 2022, Versailles, France
Poster de conférence hal-04397149 v1

Functional, structural, and binding studies of the atypical ER-resident protein FKBP7, a potential target in chemoresistant-prostate cancer

Luce Dreno , Sofian Lacoste , Carolina Tiraboschi , Sofia Calpe , Marine Garrido et al.
AACR Annual Meeting, Apr 2022, New Orleans, United States
Poster de conférence hal-04396828 v1

FUNCTIONAL, STRUCTURAL AND BINDING STUDIES OF THE ATYPICAL ER-RESIDENT PROTEIN FKBP7, A POTENTIAL TARGET IN CHEMORESISTANT PROSTATE CANCER

Luce Dreno , Sofian Lacoste , Carolina Tiraboschi , Marine Garrido , Mariana Tannoury et al.
Journée Scientifique ARTP, Nov 2022, Paris, France
Poster de conférence hal-04396877 v1

The ER-resident FKBP7: a new candidate for the Endoplasmic Reticulum to Cytosol Signaling (ERCYS) pathway?

Luce Dreno , Marine Garrido , Matthieu Bertrand , Sofia Calpe , Mariana Tannoury et al.
Endoplasmic Reticulum 2021 symposium, Oct 2021, Paris, France
Poster de conférence hal-04396910 v1

Structural studies of cyclodipeptide synthases with RNA microhelices mimicking their natural tRNA susbtrates

Zahra Marouf , Nelly Morellet , Carine Tellier , Matthieu Glousieau , Eric Jacquet et al.
congrès BSI, Nov 2021, Gif-sur-Yvette, France
Poster de conférence hal-04397035 v1

ParaHP-NMR: Paramagnetic effects under high hydrostatic pressure NMR to probe the structure of proteins and contrast agents.

François Giraud , Anthony Potenza , Philippe Durand , Xu Dong , Wenxue Jiang et al.
Congrès BSI, Nov 2021, Gif-sur-Yvette, France
Poster de conférence hal-04396420 v1

High-Pressure NMR to probe protein and lipid bilayer structure/dynamics

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
Congrès BSI, Nov 2021, Gif-sur-Yvette, France
Poster de conférence hal-04396409 v1

La RMN sous pression hydrostatique: un outil pour caractériser la structure et la dynamique de biomolécules.

Giraud François , Dong Xu , Gong Zhou , Chun Tang , Ewen Lescop
Forum haute pression, Oct 2020, Oléron, France
Poster de conférence hal-04396383 v1

IN SITU PEPTIDE RELEASE KINETICS FROM LIPOSOME FORMULATION MONITORED BY NMR SPECTROSCOPY

Camille Doyen , Eric Larquet , Pierre-Damien Coureux , Oriane Frances , Frédéric Herman et al.
EUROISMAR, Aug 2019, Berlin (DE), Germany
Poster de conférence hal-04396375 v1

Real-time, in situ peptide-liposome formulation release kinetics monitored by NMR spectroscopy

Camille Doyen , Eric Larquet , Pierre-Damien Coureux , Oriane Frances , Frédéric Herman et al.
COMET, Feb 2019, Cergy, France
Poster de conférence hal-04396372 v1
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Interaction of the Cysteine-Rich Domain of the Paramecium domesticated transposase PiggyMac with histone H3

Luiza Mamigonian Bessa , Marc Guérineau , Séverine Moriau , Nadine Assrir , Ewen Lescop et al.
11th Conference “NMR: a tool for Biology”, Jan 2019, Paris, France. 46, pp.2660-2677, 2018
Poster de conférence hal-04381885 v1

NMR study of the structure and dynamics of the intrinsically disordered tail of ErbB2, phosphorylation and interaction

Carine van Heijenoort , Louise Pinet , Yinghui Wang , Ewen Lescop , Francoise Guerlesquin et al.
XXVIIIth International Conference on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland
Poster de conférence hal-04435655 v1

Towards NMR characterization of apelin encapsulated in liposomes.

Camille Doyen , Eric Larquet , Pierre-Damien Coureux , Oriane Frances , Frédéric Herman et al.
Euromar, Aug 2018, Nantes, France
Poster de conférence hal-04396376 v1

ASP2 : une protéine qui a du flair.

Ewen Lescop , Loïc Briand , J Claude Pernollet , Eric Guittet
17. Congrès annuel du Groupe Français d'Etudes de Résonance Magnétique, May 2001, La Pommeraye, France. 1 p., 2001
Poster de conférence hal-02830664 v1
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Structural transitions in TCTP tumor protein upon binding to the anti-apoptotic protein family member Mcl-1

Florian Malard , Christina Sizun , Aurélien Thureau , Ludovic Carlier , Ewen Lescop
Journal of Biological Chemistry, 2023, 299 (7), pp.104830. ⟨10.1016/j.jbc.2023.104830⟩
Article dans une revue hal-04208651 v1
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Revisiting the molecular interactions between the tumor protein TCTP and the drugs sertraline/thioridazine.

Florian Malard , Eric Jacquet , Naima Nhiri , Christina Sizun , Amélie Chabrier et al.
ChemMedChem, 2022, 17 (1), pp.e202100528. ⟨10.1002/cmdc.202100528⟩
Article dans une revue hal-03370569 v2
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EpyNN: Educational python for Neural Networks

Florian Malard , Laura Danner , Emilie Rouzies , Jesse Meyer , Ewen Lescop et al.
SoftwareX, 2022, 19, pp.101140. ⟨10.1016/j.softx.2022.101140⟩
Article dans une revue hal-03795656 v1
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Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain

Assia Mouhand , Loussiné Zargarian , Anissa Belfetmi , Marjorie Catala , Marco Pasi et al.
Viruses, 2022, 14 (3), pp.632. ⟨10.3390/v14030632⟩
Article dans une revue hal-03671481 v1
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Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure

Alexandre Pozza , François Giraud , Quentin Cece , Marina Casiraghi , Elodie Point et al.
Nature Communications, 2022, 13 (1), pp.1780. ⟨10.1038/s41467-022-29410-5⟩
Article dans une revue hal-03665500 v1
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Drimane derivatives as the first examples of covalent BH3-mimetics that target MCL-1

Florian Daressy , Florian Malard , Line Seguy , Vincent Guérineau , Cécile Apel et al.
ChemMedChem, 2021, 16 (11), pp.1789-1798. ⟨10.1002/cmdc.202100011⟩
Article dans une revue hal-03279424 v1
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Nuclear Magnetic Resonance Spectroscopy: A Multifaceted Toolbox to Probe Structure, Dynamics, Interactions, and Real-Time In Situ Release Kinetics in Peptide-Liposome Formulations

Camille Doyen , Eric Larquet , Pierre-Damien Coureux , Oriane Frances , Frédéric Herman et al.
Molecular Pharmaceutics, 2021, 18 (7), pp.2521-2539. ⟨10.1021/acs.molpharmaceut.1c00037⟩
Article dans une revue hal-03301899 v1
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Structural and dynamic characterization of the C-terminal tail of ErbB2: disordered but not random

L. Pinet , Y.-H. Wang , C. Deville , E. Lescop , F. Guerlesquin et al.
Biophysical Journal, 2021, 120 (10), pp.1869-1882. ⟨10.1016/j.bpj.2021.03.005⟩
Article dans une revue hal-03095358 v2
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The unusual structure of the PiggyMac cysteine-rich domain reveals zinc finger diversity in PiggyBac-related transposases

Marc Guérineau , Luiza Bessa , Séverine Moriau , Ewen Lescop , François Bontems et al.
Mobile DNA, 2021, 12 (1), ⟨10.1186/s13100-021-00240-4⟩
Article dans une revue hal-03302627 v1
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NMR Characterization of the Influence of Zinc(II) Ions on the Structural and Dynamic Behavior of the New Delhi Metallo-β-Lactamase-1 and on the Binding with Flavonols as Inhibitors

Gwladys Rivière , Saoussen Oueslati , Maud Gayral , Jean-Bernard Créchet , Naïma Nhiri et al.
ACS Omega, 2020, 5 (18), pp.10466-10480. ⟨10.1021/acsomega.0c00590⟩
Article dans une revue hal-02604220 v1
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YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis

Dmitry Kretov , Marie-Jeanne Clément , Guillaume Lambert , Dominique Durand , Dmitry Lyabin et al.
Nucleic Acids Research, 2019, 47 (6), pp.3127-3141. ⟨10.1093/nar/gky1303⟩
Article dans une revue hal-02114790 v1
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Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25

Kévin Jeanne Dit Fouque , Julian D Hegemann , Séverine Zirah , Sylvie Rebuffat , Ewen Lescop et al.
Journal of The American Society for Mass Spectrometry, 2019, 30 (6), pp.1038-1045. ⟨10.1007/s13361-019-02134-5⟩
Article dans une revue hal-02114349 v1
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Natural Chlordecone Degradation Revealed by Numerous Transformation Products Characterized in Key French West Indies Environmental Compartments

Marion L. Chevallier , Oriane Della-Negra , Sébastien Chaussonnerie , Agnès Barbance , Delphine Muselet et al.
Environmental Science and Technology, 2019, 53 (11), pp.6133-6143. ⟨10.1021/acs.est.8b06305⟩
Article dans une revue hal-02309073 v1

Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch

Shang-Xiang Ye , Zhou Gong , Ju Yang , Yu-Xin An , Zhu Liu et al.
Protein and Cell, 2019, ⟨10.1007/s13238-019-0644-x⟩
Article dans une revue hal-02309074 v1
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Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome

Christelle C. Arrondel , Sophia Missoury , Rozemarijn Snoek , Julie Patat , Giulia Menara et al.
Nature Communications, 2019, 10 (1), pp.3967. ⟨10.1038/s41467-019-11951-x⟩
Article dans une revue inserm-02322309 v1

Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics

Eric André , Valérie Derrien , Pierre Sebban , Nadine Assrir , Ewen Lescop et al.
Journal of Biological Inorganic Chemistry, 2019, 24 (1), pp.39-52. ⟨10.1007/s00775-018-1625-x⟩
Article dans une revue hal-02114795 v1
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The H 2 O 2 -Resistant Fe–S Redox Switch MitoNEET Acts as a pH Sensor To Repair Stress-Damaged Fe–S Protein

Cécile Mons , Thomas Botzanowski , Anton Nikolaev , Petra Hellwig , Sarah Cianférani et al.
Biochemistry, 2018, 57 (38), pp.5616-5628. ⟨10.1021/acs.biochem.8b00777⟩
Article dans une revue hal-02129718 v1
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Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase

Nelly Morellet , Xianghong Li , Silke Wieninger , Jennifer Taylor , Julien Bischerour et al.
Nucleic Acids Research, 2018, 46 (5), pp.2660-2677. ⟨10.1093/nar/gky044⟩
Article dans une revue hal-02114800 v1
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Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters

Maria Romano , Giuliana Fusco , Hassanul G Choudhury , Shahid Mehmood , Carol V Robinson et al.
ACS Chemical Biology, 2018, 13 (6), pp.1598 - 1609. ⟨10.1021/acschembio.8b00226⟩
Article dans une revue hal-03301757 v1

Illuminating the Energy Landscape of GPCRs: The Key Contribution of Solution-State NMR Associated with Escherichia coli as an Expression Host

Marina Casiraghi , Marjorie Damian , Ewen Lescop , Jean-Louis Banères , Laurent J Catoire
Biochemistry, 2018, 57 (16), pp.2297-2307. ⟨10.1021/acs.biochem.8b00035⟩
Article dans une revue hal-03011579 v1
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Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation

Florian Malard , Nadine Assrir , Mouad Alami , Samir Messaoudi , Ewen Lescop et al.
Journal of Molecular Biology, 2018, 430 (11), pp.1621-1639. ⟨10.1016/j.jmb.2018.04.024⟩
Article dans une revue hal-02114798 v1

1H, 13C and 15N assignments of the C-terminal intrinsically disordered cytosolic fragment of the receptor tyrosine kinase ErbB2

Yinghui Wang , Louise Pinet , Nadine Assrir , Latifa Elantak , Francoise Guerlesquin et al.
Biomolecular NMR Assignments, 2017, 12 (1), pp.23 - 26. ⟨10.1007/s12104-017-9773-4⟩
Article dans une revue hal-01791552 v1
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New insights into structural disorder in human respiratory syncytial virus phosphoprotein and implications for binding of protein partners

Nelson Pereira , Christophe Cardone , Safa Lassoued , Marie Galloux , Jenna Fix et al.
Journal of Biological Chemistry, 2017, 292 (6), pp.2120-2131. ⟨10.1074/jbc.M116.765958⟩
Article dans une revue hal-01605660 v1
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Combined Biochemical, Biophysical, and Cellular Methods to Study Fe–S Cluster Transfer and Cytosolic Aconitase Repair by MitoNEET

Cécile Mons , Ioana Ferecatu , Sylvie Riquier , Ewen Lescop , Cécile Bouton et al.
Methods in Enzymology, 2017, 595, pp.83-106. ⟨10.1016/bs.mie.2017.07.010⟩
Article dans une revue hal-01873518 v1
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Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster

Marie-Pierre Golinelli-Cohen , Ewen Lescop , Cécile Mons , Sergio Gonçalves , Martin Clémancey et al.
Journal of Biological Chemistry, 2016, 291 (14), pp.7583 - 7593. ⟨10.1074/jbc.m115.711218⟩
Article dans une revue hal-01873511 v1

Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer

Marina Casiraghi , Marjorie Damian , Ewen Lescop , Elodie Point , Karine Moncoq et al.
Journal of the American Chemical Society, 2016, 138 (35), pp.11170-11175. ⟨10.1021/jacs.6b04432⟩
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Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo

Marie-Aude Plamont , Emmanuelle Billon-Denis , Sylvie Maurin , Carole Gauron , Frederico M. Pimenta et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (3), pp.497-502. ⟨10.1073/pnas.1513094113⟩
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Intramolecular Pd-Catalyzed Arylation of 1-Amidosugars: A New Route to N -Glycosyl Quinolin-2-ones

Thi Thanh Huyen Luong , Jean-Daniel Brion , Ewen Lescop , Mouad Alami , Samir Messaoudi
Organic Letters, 2016, 18 (9), pp.2126-2129. ⟨10.1021/acs.orglett.6b00752⟩
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Initial Molecular Recognition Steps of McjA Precursor during Microcin J25 Lasso Peptide Maturation

Nadine Assrir , Anna Pavelkova , Régine Dazzoni , Rémi Ducasse , Nelly Morellet et al.
ChemBioChem, 2016, 17 (19), pp.1851-1858. ⟨10.1002/cbic.201600306⟩
Article dans une revue istex hal-02118696 v1

Characterization of Sviceucin from Streptomyces Provides Insight into Enzyme Exchangeability and Disulfide Bond Formation in Lasso Peptides.

Yanyan Li , Rémi Ducasse , Séverine Zirah , Alain Blond , Christophe Goulard et al.
ACS Chemical Biology, 2015, 10 (11), pp.2641-9. ⟨10.1021/acschembio.5b00584⟩
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A Well-Balanced Preexisting Equilibrium Governs Electron Flux Efficiency of a Multidomain Diflavin Reductase

Oriane Frances , Fataneh Fatemi , Denis Pompon , Eric Guittet , Christina Sizun et al.
Biophysical Journal, 2015, 108 (6), pp.1527-1536. ⟨10.1016/j.bpj.2015.01.032⟩
Article dans une revue hal-01142871 v1
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The Diabetes Drug Target MitoNEET Governs a Novel Trafficking Pathway to Rebuild an Fe-S Cluster into Cytosolic Aconitase/Iron Regulatory Protein 1

Ioana Ferecatu , Sergio Gonçalves , Marie-Pierre Golinelli-Cohen , Martin Clémancey , Alain Martelli et al.
Journal of Biological Chemistry, 2014, 289 (41), pp.28070 - 28086. ⟨10.1074/jbc.m114.548438⟩
Article dans une revue hal-01873509 v1

Mapping the UDP-N-acetylglucosamine regulatory site of human glucosamine-6P synthase by saturation-transfer difference NMR and site-directed mutagenesis.

Nadine Assrir , Celine Richez , Philippe Durand , Eric Guittet , Bernard Badet et al.
Biochimie, 2014, 97, pp.39-48. ⟨10.1016/j.biochi.2013.09.011⟩
Article dans une revue hal-00912794 v1

Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides.

Amandine Altmayer-Henzien , Valérie Declerck , David J Aitken , Ewen Lescop , Denis Merlet et al.
Organic & Biomolecular Chemistry, 2013, 11 (43), pp.7611-5. ⟨10.1039/c3ob41876f⟩
Article dans une revue hal-00912800 v1

Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin.

Anthony Bocahut , Valérie Derrien , Sophie Bernad , Pierre Sebban , Sophie Sacquin-Mora et al.
Journal of Biological Inorganic Chemistry, 2013, 18 (1), pp.111-22. ⟨10.1007/s00775-012-0956-2⟩
Article dans une revue hal-00783539 v1

Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin

A Bocahut , V Derrien , S Bernad , P. Sebban , S Sacquin-Mora et al.
Journal of Biological Inorganic Chemistry, 2013, 18 (1)
Article dans une revue hal-01326196 v1

Fast protein backbone NMR resonance assignment using the BATCH strategy.

Bernhard Brutscher , Ewen Lescop
Methods in Molecular Biology, 2012, 831, pp.407-28. ⟨10.1007/978-1-61779-480-3_21⟩
Article dans une revue hal-00798115 v1
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Dynamic control of electron transfers in diflavin reductases.

Louise Aigrain , Fataneh Fatemi , Oriane Frances , Ewen Lescop , Gilles Truan
International Journal of Molecular Sciences, 2012, 13 (11), pp.15012-41. ⟨10.3390/ijms131115012⟩
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Optimization of the production of gurmarin, a sweet-taste-suppressing protein, secreted by the methylotrophic yeast Pichia pastoris.

Maud Sigoillot , Anne Brockhoff , Ewen Lescop , Nicolas Poirier , Wolfgang Meyerhof et al.
Applied Microbiology and Biotechnology, 2012, 96 (5), pp.1253-63. ⟨10.1007/s00253-012-3897-3⟩
Article dans une revue istex hal-00763833 v1

Sequence determinants governing the topology and biological activity of a lasso Peptide, microcin J25.

Rémi Ducasse , Kok-Phen Yan , Christophe Goulard , Alain Blond , Yanyan Li et al.
ChemBioChem, 2012, 13 (3), pp.371-80. ⟨10.1002/cbic.201100702⟩
Article dans une revue istex hal-00678535 v1

The closed and compact domain organization of the 70-kDa human cytochrome P450 reductase in its oxidized state as revealed by NMR.

Bruno Vincent , Nelly Morellet , Fataneh Fatemi , Louise Aigrain , Gilles Truan et al.
Journal of Molecular Biology, 2012, 420 (4-5), pp.296-309. ⟨10.1016/j.jmb.2012.03.022⟩
Article dans une revue istex hal-00733233 v1

Rapid measurement of residual dipolar couplings for fast fold elucidation of proteins.

Rodolfo M Rasia , Ewen Lescop , Javier F Palatnik , Jérôme Boisbouvier , Bernhard Brutscher
Journal of Biomolecular NMR, 2011, 51 (3), pp.369-78. ⟨10.1007/s10858-011-9567-4⟩
Article dans une revue istex hal-00689143 v1

Structure, dynamics, and kinetics of weak protein-protein complexes from NMR spin relaxation measurements of titrated solutions.

Loïc Salmon , José-Luis Ortega Roldan , Ewen Lescop , Antoine Licinio , Nico van Nuland et al.
Angewandte Chemie International Edition, 2011, 50 (16), pp.3755-3759. ⟨10.1002/anie.201100310⟩
Article dans une revue istex hal-00605370 v1

La résonance magnétique nucléaire au service de la biologie structurale

N. Birlirakis , F. Bontems , E. Guittet , J. L. Leroy , E. Lescop et al.
L'Actualité Chimique, 2011, 353-354, pp.100-109
Article dans une revue hal-00759164 v1

Guidelines for the use of band-selective radiofrequency pulses in hetero-nuclear NMR: Example of longitudinal-relaxation-enhanced BEST-type 1H­15N correlation experiments

E. Lescop , T. Kern , B. Brutscher
Journal of Magnetic Resonance, 2010, 203 (1), pp.190-198. ⟨10.1016/j.jmr.2009.12.001⟩
Article dans une revue istex hal-00464636 v1

Structural basis of the broad specificity of a General Odorant-Binding Protein from honeybee.

Ewen Lescop , Loïc Briand , Jean-Claude Pernollet , Eric Guittet
Biochemistry, 2009, 48 (11), pp.2431-2441. ⟨10.1021/bi802300k⟩
Article dans une revue hal-00375337 v1

Highly automated protein backbone resonance assignment within a few hours: the "BATCH" strategy and software package.

Ewen Lescop , Bernhard Brutscher
Journal of Biomolecular NMR, 2009, 44 (1), pp.43-57. ⟨10.1007/s10858-009-9314-2⟩
Article dans une revue istex hal-00385027 v1

Dynamics of the Conformational Transitions in the Assembling of the Michaelis Complex of a Bisubstrate Enzyme: A 15 N Relaxation Study of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase †

Ewen Lescop , Zhenwei Lu , Qin Liu , Huimin Xu , Guangyu Li et al.
Biochemistry, 2009, 48 (2), pp.302-312. ⟨10.1021/bi8016262⟩
Article dans une revue hal-02114811 v1

Hadamard Amino-Acid-Type Edited NMR Experiment for Fast Protein Resonance Assignment

Ewen Lescop , Rodolfo Rasia , Bernhard Brutscher
Journal of the American Chemical Society, 2008, 130 (15), pp.5014-5015. ⟨10.1021/ja800914h⟩
Article dans une revue istex hal-02114814 v1

Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: application to the molecular recognition element of Sendai virus nucleoprotein.

Malene Ringkjøbing Jensen , Klaartje Houben , Ewen Lescop , Laurence Blanchard , Rob W H Ruigrok et al.
Journal of the American Chemical Society, 2008, 130 (25), pp.8055-61. ⟨10.1021/ja801332d⟩
Article dans une revue istex hal-00337329 v1

Hyperdimensional Protein NMR Spectroscopy in Peptide-Sequence Space

Ewen Lescop , Bernhard Brutscher
Journal of the American Chemical Society, 2007, 129 (39), pp.11916-11917. ⟨10.1021/ja0751577⟩
Article dans une revue istex hal-02114815 v1

A set of BEST triple-resonance experiments for time-optimized protein resonance assignment

Ewen Lescop , Paul Schanda , Bernhard Brutscher
Journal of Magnetic Resonance, 2007, 187 (1), pp.163-169. ⟨10.1016/j.jmr.2007.04.002⟩
Article dans une revue istex hal-02116026 v1

Conformational Fluctuations Coupled to the Thiol-Disulfide Transfer between Thioredoxin and Arsenate Reductase in Bacillus subtilis

You Li , Yunfei Hu , Xinxin Zhang , Huimin Xu , Ewen Lescop et al.
Journal of Biological Chemistry, 2007, 282 (15), pp.11078-11083. ⟨10.1074/jbc.M700970200⟩
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Automated Spectral Compression for Fast Multidimensional NMR and Increased Time Resolution in Real-Time NMR Spectroscopy

Ewen Lescop , Paul Schanda , Rodolfo Rasia , Bernhard Brutscher
Journal of the American Chemical Society, 2007, 129 (10), pp.2756-2757. ⟨10.1021/ja068949u⟩
Article dans une revue istex hal-02118645 v1

Sensitivity-optimized experiment for the measurement of residual dipolar couplings between amide protons

Paul Schanda , Ewen Lescop , Mirjam Falge , Rémy Sounier , Jérôme Boisbouvier et al.
Journal of Biomolecular NMR, 2007, 38 (1), pp.47-55. ⟨10.1007/s10858-006-9138-2⟩
Article dans une revue istex hal-02116021 v1

The Solution Structure of Escherichia coli Wzb Reveals a Novel Substrate Recognition Mechanism of Prokaryotic Low Molecular Weight Protein-tyrosine Phosphatases

Xinxin Zhang , Xianrong Guo , You Li , Ewen Lescop , Yunfei Hu et al.
Journal of Biological Chemistry, 2006, 281 (28), pp.19570-19577. ⟨10.1074/jbc.M601263200⟩
Article dans une revue hal-02116001 v1

The Bacillus subtilis YkuV Is a Thiol:Disulfide Oxidoreductase Revealed by Its Redox Structures and Activity

Xinxin Zhang , Yunfei Hu , Xianrong Guo , Ewen Lescop , You Li et al.
Journal of Biological Chemistry, 2006, 281 (12), pp.8296-8304. ⟨10.1074/jbc.M512015200⟩
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Novel Azapeptide Inhibitors of Hepatitis C Virus Serine Protease

Murray Bailey , Ted Halmos , Nathalie Goudreau , Ewen Lescop , Montse Llinàs-Brunet
Journal of Medicinal Chemistry, 2004, 47 (15), pp.3788-3799. ⟨10.1021/jm049864b⟩
Article dans une revue istex hal-02118644 v1

1H, 13C and 15N chemical shift assignment of the honeybee odorant-binding protein ASP2.

Ewen Lescop , Loïc Briand , Jean-Claude Pernollet , Carine van Heijenoort , Eric Guittet
Journal of Biomolecular NMR, 2001, 21 (2), pp.181-182. ⟨10.1023/A:1012428527813⟩
Article dans une revue istex hal-02115990 v1

Isotopic Double-Labeling of Two Honeybee Odorant-Binding Proteins Secreted by the Methylotrophic Yeast Pichia pastoris

Loïc Briand , Ewen Lescop , Valérie Bézirard , Nicolas Birlirakis , Jean-Claude Huet et al.
Protein Expression and Purification, 2001, 23 (1), pp.167-174. ⟨10.1006/prep.2001.1478⟩
Article dans une revue istex hal-02115992 v1

Isotopic double-labeling of two honeybee odorant-binding proteins secreted by the methylotrophic yeast Pichia pastoris

Loïc Briand , Ewen Lescop , Valérie Bézirard , Nicolas Birlirakis , Jean-Claude Huet et al.
Protein Expression and Purification, 2001, 23, pp.167-174
Article dans une revue hal-02671654 v1