Gabriel MARKOV

CRCN CNRS
44
Documents
Affiliation actuelle
  • Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M)

Présentation

I investigate metabolic pathway evolution, integrating information about the evolution of single enzymes with the distribution of metabolites accross lineages. This led me to develop methods to tackle directly the evolution of pathways at that level of abstraction. I am strongly interested about eukaryotic metabolic pathways for which there is a significant amount of detailed biological knowledge, such as those producing signaling molecules.

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Publications

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Differential impact of copper stress in two Ectocarpales: metabolic disruption and defensive signaling in the free-living Ectocarpus sp7 and the endophytic Laminarionema elsbetiae

Maëlle Zonnequin , Marine Vallet , Ludovic Delage , Georg Pohnert , Catherine Leblanc et al.

Biochimie, 2025, 239, pp.93-102. ⟨10.1016/j.biochi.2025.10.006⟩

Article dans une revue hal-05405218v1
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Sterol biosynthesis and phytosterol bioconversion in Crassostrea gigas larvae: new evidence from mass-balance feeding studies

Fiz da Costa , Margaux Mathieu-Resuge , Fabienne Le Grand , Claudie Quéré , Gabriel V. Markov et al.

Biochimie, 2025, 239, Part A, pp.51-59. ⟨10.1016/j.biochi.2025.05.005⟩

Article dans une revue hal-05405141v1
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Cholesterol and sterols in molluscan endocrinology: past, present, future

István Fodor , Gabriel V. Markov , Luis Alfonso Yañez-Guerra , Károly Elekes , Edit Pollák et al.

Frontiers in Endocrinology, 2025, 16, ⟨10.3389/fendo.2025.1627166⟩

Article dans une revue hal-05405123v1
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Plant and algal lipidomes: Analysis, composition, and their societal significance

Juliette Jouhet , Eliana Alves , Yohann Boutté , Sylvain Darnet , Frédéric Domergue et al.

Progress in Lipid Research, 2024, 96, pp.101290. ⟨10.1016/j.plipres.2024.101290⟩

Article dans une revue hal-04673335v1
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Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems

France Denoeud , Olivier Godfroy , Corinne Cruaud , Svenja Heesch , Zofia Nehr et al.

Cell, 2024, 187 (24), pp.6943-6965. ⟨10.1016/j.cell.2024.10.049⟩

Article dans une revue hal-04794231v1
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A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications

Coralie Rousseau , Gautier Demoulinger , Sylvie Rousvoal , Delphine Champeval , Maurane Dolly et al.

Comptes Rendus. Chimie, 2024, 26 (S2), pp.1-25. ⟨10.5802/crchim.271⟩

Article dans une revue hal-04740350v1
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Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways

Maëlle Zonnequin , Arnaud Belcour , Ludovic Delage , Anne Siegel , Samuel Blanquart et al.

Frontiers in Plant Science, 2024, 15, pp.1339132. ⟨10.3389/fpls.2024.1339132⟩

Article dans une revue (article de synthèse) hal-04473577v1
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Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA

Abdul Kareem Mohideen Patel , Pierre Vilela , Tajith Baba Shaik , Alastair G Mcewen , Isabelle Hazemann et al.

Nucleic Acids Research, 2023, 51 (16), pp.8864-8879. ⟨10.1093/nar/gkad632⟩

Article dans une revue hal-04234634v1
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Aldehyde perception induces specific molecular responses in Laminaria digitata and affects algal consumption by a specialist grazer

Qikun Xing , Léa Cabioch , Antoine Desrut , Gildas Le Corguillé , Sylvie Rousvoal et al.

The Plant Journal, In press, ⟨10.1111/tpj.16450⟩

Article dans une revue hal-04197531v1
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Inferring and comparing metabolism across heterogeneous sets of annotated genomes using AuCoMe

Arnaud Belcour , Jeanne Got , Méziane Aite , Ludovic Delage , Jonas Collén et al.

Genome Research, 2023, 33, pp.972 - 987. ⟨10.1101/gr.277056.122⟩

Article dans une revue hal-04192851v3
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A novel nuclear receptor subfamily enlightens the origin of heterodimerization

Brice Beinsteiner , Gabriel V Markov , Maxime Bourguet , Alastair G Mcewen , Stéphane Erb et al.

BMC Biology, 2022, 20 (1), pp.217. ⟨10.1186/s12915-022-01413-0⟩

Article dans une revue hal-03843774v1
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Independent Evolution of the MYB Family in Brown Algae

Qiangcheng Zeng , Hanyu Liu , Xiaonan Chu , Yonggang Niu , Caili Wang et al.

Frontiers in Genetics, 2022, 12, ⟨10.3389/fgene.2021.811993⟩

Article dans une revue hal-03938547v1
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Small molecules as products of evolution

Gabriel Markov , Vincent Laudet

Current Biology, 2022, 32 (3), pp.R100-R105. ⟨10.1016/j.cub.2021.12.038⟩

Article dans une revue hal-03937973v1
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A structural signature motif enlightens the origin and diversification of nuclear receptors

Brice Beinsteiner , Gabriel V Markov , Stéphane Erb , Yassmine Chebaro , Alastair G Mcewen et al.

PLoS Genetics, 2021, 17 (4), pp.e1009492. ⟨10.1371/journal.pgen.1009492⟩

Article dans une revue hal-03222330v1

Different Early Responses of Laminariales to an Endophytic Infection Provide Insights About Kelp Host Specificity

Qikun Xing , Miriam Bernard , Sylvie Rousvoal , Erwan Corre , Gabriel Markov et al.

Frontiers in Marine Science, 2021, 8, ⟨10.3389/fmars.2021.742469⟩

Article dans une revue hal-03454704v1
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Semi-Quantitative Targeted Gas Chromatography-Mass Spectrometry Profiling Supports a Late Side-Chain Reductase Cycloartenol-to-Cholesterol Biosynthesis Pathway in Brown Algae

Jean Girard , Goulven Lanneau , Ludovic Delage , Cédric Leroux , Arnaud Belcour et al.

Frontiers in Plant Science, 2021, 12, pp.1-10. ⟨10.3389/fpls.2021.648426⟩

Article dans une revue hal-03222505v1
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Biological rhythms in the deep-sea hydrothermal mussel Bathymodiolus azoricus

Audrey Mat , Jozée Sarrazin , Gabriel Markov , Vincent Apremont , Christine Dubreuil et al.

Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-17284-4⟩

Article dans une revue hal-02907599v1
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The genome of Ectocarpus subulatus – A highly stress-tolerant brown alga

Simon M. Dittami , Erwan Corre , Loraine Brillet-Guéguen , Agnieszka Lipinska , Noé Pontoizeau et al.

Marine Genomics, 2020, 52, pp.100740. ⟨10.1016/j.margen.2020.100740⟩

Article dans une revue hal-02866117v1
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Inferring Biochemical Reactions and Metabolite Structures to Understand Metabolic Pathway Drift

Arnaud Belcour , Jean Girard , Méziane Aite , Ludovic Delage , Camille Trottier et al.

iScience, 2020, 23 (2), pp.100849. ⟨10.1016/j.isci.2020.100849⟩

Article dans une revue hal-01943880v2
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Genome–Scale Metabolic Networks Shed Light on the Carotenoid Biosynthesis Pathway in the Brown Algae Saccharina japonica and Cladosiphon okamuranus

Delphine Nègre , Méziane Aite , Arnaud Belcour , Clémence Frioux , Loraine Brillet-Guéguen et al.

Antioxidants , 2019, 8 (11), pp.564. ⟨10.3390/antiox8110564⟩

Article dans une revue hal-02395080v1
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Diversity and evolution of cytochromes P450 in stramenopiles

Linhong Teng , Xiao Fan , David R. Nelson , Wentao Han , Xiao Zhang et al.

Planta, 2019, 249 (3), pp.647-661. ⟨10.1007/s00425-018-3028-1⟩

Article dans une revue hal-02065007v1
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NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding

Konstantin Khalturin , Isabelle Billas , Yassmine Chebaro , Adam M. Reitzel , Ann M. Tarrant et al.

Journal of Steroid Biochemistry and Molecular Biology, 2018, 184, pp.11-19. ⟨10.1016/j.jsbmb.2018.06.014⟩

Article dans une revue hal-02017750v1
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Traceability, reproducibility and wiki-exploration for "à-la-carte" reconstructions of genome-scale metabolic models

Méziane Aite , Marie Chevallier , Clémence Frioux , Camille Trottier , Jeanne Got et al.

PLoS Computational Biology, 2018, 14 (5), pp.e1006146. ⟨10.1371/journal.pcbi.1006146⟩

Article dans une revue hal-01807842v1
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Hormonally active phytochemicals from macroalgae: a largely untapped source of ligands to deorphanize nuclear receptors in emerging marine animal models

Gabriel V. Markov , Jean Girard , Vincent Laudet , Catherine Leblanc

General and Comparative Endocrinology, 2018, 265, pp.41-45. ⟨10.1016/j.ygcen.2018.06.004⟩

Article dans une revue hal-02393542v1

Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis

Jan Falcke , Neelanjan Bose , Alexander Artyukhin , Christian Rödelsperger , Gabriel V. Markov et al.

Cell Chemical Biology, 2018, 25 (6), pp.787-796.e12. ⟨10.1016/j.chembiol.2018.04.004⟩

Article dans une revue hal-03941058v1
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Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen

Gabriel Markov , Juliana Gutierrez-Mazariegos , Delphine Pitrat , Isabelle M. L. Billas , François Bonneton et al.

Science Advances , 2017, 3 (3), pp.e1601778. ⟨10.1126/sciadv.1601778⟩

Article dans une revue hal-01693173v1
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Functional Conservation and Divergence of<i>daf-22</i>Paralogs in<i>Pristionchus pacificus</i>Dauer Development

Gabriel V. Markov , Jan M Meyer , Oishika Panda , Alexander B Artyukhin , Marc Claaßen et al.

Molecular Biology and Evolution, 2016, 33 (10), pp.2506 - 2514. ⟨10.1093/molbev/msw090⟩

Article dans une revue hal-04460142v1
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On the origin and evolutionary history of NANOG

Pierluigi Scerbo , Gabriel V Markov , Céline Vivien , Laurent Kodjabachian , Barbara Demeneix et al.

PLoS ONE, 2014, 9 (1), pp.e85104. ⟨10.1371/journal.pone.0085104⟩

Article dans une revue hal-01111124v1
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Ventx factors function as Nanog-like guardians of developmental potential in Xenopus

Pierluigi Scerbo , Fabrice Girardot , Céline Vivien , Gabriel V Markov , Guillaume Luxardi et al.

PLoS ONE, 2012, 7 (5), pp.e36855. ⟨10.1371/journal.pone.0036855⟩

Article dans une revue hal-00843463v1

Origin and evolution of the ligand-binding ability of nuclear receptors

Gabriel Markov , Vincent Laudet

Molecular and Cellular Endocrinology, 2011, 334 (1-2), pp.21 - 30. ⟨10.1016/j.mce.2010.10.017⟩

Article dans une revue istex hal-02648059v1

Evolution of Nuclear Retinoic Acid Receptor Alpha (RAR alpha) Phosphorylation Sites. Serine Gain Provides Fine-Tuned Regulation

Eric Samarut , Ismail Amal , Gabriel Markov , Roland Stote , Annick Dejaegere et al.

Molecular Biology and Evolution, 2011, 28 (7), pp.2125 - 2137. ⟨10.1093/molbev/msr035⟩

Article dans une revue hal-02645447v1

Independent elaboration of steroid hormone signaling pathways in metazoans

Gabriel V Markov , Raquel Tavares , Chantal Dauphin-Villemant , Barbara A. Demeneix , Michael E. Baker et al.

Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (29), pp.11913-11918. ⟨10.1073/pnas.0812138106⟩

Article dans une revue hal-02666864v1

Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita

Pierre Abad , Jerome Gouzy , Jean-Marc Aury , Philippe Castagnone-Sereno , Etienne Danchin et al.

Nature Biotechnology, 2008, 26 (8), pp.909-915. ⟨10.1038/nbt.1482⟩

Article dans une revue hal-01189285v1
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The evolution of the ligand/receptor couple: a long road from comparative endocrinology to comparative genomics

Gabriel V Markov , Mathilde Paris , Stephanie Bertrand , Vincent Laudet

Molecular and Cellular Endocrinology, 2008, 293 (1-2), pp.5. ⟨10.1016/j.mce.2008.06.011⟩

Article dans une revue hal-00532041v1

The "street light syndrome", or how protein taxonomy can bias experimental manipulations

Gabriel Markov , Guillaume Lecointre , Barbara Demeneix , Vincent Laudet

BioEssays, 2008, 30 (4), pp.349-357. ⟨10.1002/bies.20730⟩

Article dans une revue istex hal-02662543v1
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Metagenome-scale metabolic modelling for the characterization of cross-feeding interactions in freshwater cyanobacteria-associated microbial communities

Juliette Audemard , Nicolas Creusot , Julie Leloup , Charlotte Duval , Sébastien Halary et al.

JOBIM 2025 - Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2025, Bordeaux, France

Communication dans un congrès hal-05281552v1
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Methods for a species-specific genome-scale metabolic model designed for eukaryotes and applied to the Ascophyllum nodosum macroalga

Pauline Hamon-Giraud , Benoît Bergk Pinto , Jeanne Got , Coralie Rousseau , Erwan Corre et al.

JOBIM 2025 - Journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2025, Bordeaux, France. pp.109-117

Communication dans un congrès hal-05374724v1

Evolution of nuclear receptors in insects

François Bonneton , Arnaud Chaumot , T. Iwema , I. Billas , D. Moras et al.

18th International Ecdysone Workshop 2010, Jul 2010, Ceske Budejovice, Czech Republic. pp.1

Communication dans un congrès hal-02593438v1

Evolution of hormonal mechanisms

Brice Beinsteiner , Isabelle M.L. Billas , Dino Moras , Vincent Laudet , Gabriel V. Markov

Ilpo Huhtaniemi, Luciano Martini. Encyclopedia of Endocrine Diseases, 3rd edition, Elsevier, 2025, 9780128122006. ⟨10.1016/B978-0-443-13825-6.00251-X⟩

Chapitre d'ouvrage hal-05405253v1
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Evolution of Hormonal Mechanisms

Vincent Laudet , Gabriel V. Markov

Encyclopedia of Endocrine Diseases, Second Edition, 2018, 978-0-12-812200-6. ⟨10.1016/B978-0-12-812199-3.64198-1⟩

Chapitre d'ouvrage hal-03941018v1

Biologie intégrative des organismes photosynthétiques et micro-organismes associés

Cécile Raynaud , Laurent Nussaume , Fabrice Besnard , Ugo Cenci , Daniel Clesse et al.

CNRS - Biologie intégrative des organismes photosynthétiques et micro-organismes associés (Section 23). 2025, pp.381-389

Rapport (rapport d’expertise collective) hal-05492655v1
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Evolution of Steroid Signaling in Metazoans

Gabriel Markov

Agricultural sciences. Ecole normale supérieure de lyon - ENS LYON, 2011. English. ⟨NNT : 2011ENSL0634⟩

Thèse tel-01373637v1