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Gabriel MARKOV



I investigate metabolic pathway evolution, integrating information about the evolution of single enzymes with the distribution of metabolites accross lineages. This led me to develop methods to tackle directly the evolution of pathways at that level of abstraction. I am strongly interested about eukaryotic metabolic pathways for which there is a significant amount of detailed biological knowledge, such as those producing signaling molecules.


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Inferring and comparing metabolism across heterogeneous sets of annotated genomes using AuCoMe

Arnaud Belcour , Jeanne Got , Méziane Aite , Ludovic Delage , Jonas Collén
Genome Research, 2023, 33, pp.972 - 987. ⟨10.1101/gr.277056.122⟩
Journal articles hal-04192851v1
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Semi-Quantitative Targeted Gas Chromatography-Mass Spectrometry Profiling Supports a Late Side-Chain Reductase Cycloartenol-to-Cholesterol Biosynthesis Pathway in Brown Algae

Jean Girard , Goulven Lanneau , Ludovic Delage , Cédric Leroux , Arnaud Belcour
Frontiers in Plant Science, 2021, 12, pp.1-10. ⟨10.3389/fpls.2021.648426⟩
Journal articles hal-03222505v1
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Biological rhythms in the deep-sea hydrothermal mussel Bathymodiolus azoricus

Audrey Mat , Jozée Sarrazin , Gabriel Markov , Vincent Apremont , Christine Dubreuil
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-17284-4⟩
Journal articles hal-02907599v1
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The genome of Ectocarpus subulatus – A highly stress-tolerant brown alga

Simon M. Dittami , Erwan Corre , Loraine Brillet-Guéguen , Agnieszka Lipinska , Noé Pontoizeau
Marine Genomics, 2020, 52, pp.100740. ⟨10.1016/j.margen.2020.100740⟩
Journal articles hal-02866117v1
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Inferring Biochemical Reactions and Metabolite Structures to Understand Metabolic Pathway Drift

Arnaud Belcour , Jean Girard , Méziane Aite , Ludovic Delage , Camille Trottier
iScience, 2020, 23 (2), pp.100849. ⟨10.1016/j.isci.2020.100849⟩
Journal articles hal-01943880v2
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Diversity and evolution of cytochromes P450 in stramenopiles

Linhong Teng , Xiao Fan , David R. Nelson , Wentao Han , Xiao Zhang
Planta, 2019, 249 (3), pp.647-661. ⟨10.1007/s00425-018-3028-1⟩
Journal articles hal-02065007v1
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Genome–Scale Metabolic Networks Shed Light on the Carotenoid Biosynthesis Pathway in the Brown Algae Saccharina japonica and Cladosiphon okamuranus

Delphine Nègre , Méziane Aite , Arnaud Belcour , Clémence Frioux , Loraine Brillet-Guéguen
Antioxidants , 2019, 8 (11), pp.564. ⟨10.3390/antiox8110564⟩
Journal articles hal-02395080v1

Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis

Jan Falcke , Neelanjan Bose , Alexander Artyukhin , Christian Rödelsperger , Gabriel V. Markov
Cell Chemical Biology, 2018, 25 (6), pp.787-796.e12. ⟨10.1016/j.chembiol.2018.04.004⟩
Journal articles hal-03941058v1
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Hormonally active phytochemicals from macroalgae: a largely untapped source of ligands to deorphanize nuclear receptors in emerging marine animal models

Gabriel V. Markov , Jean Girard , Vincent Laudet , Catherine Leblanc
General and Comparative Endocrinology, 2018, 265, pp.41-45. ⟨10.1016/j.ygcen.2018.06.004⟩
Journal articles hal-02393542v1
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Traceability, reproducibility and wiki-exploration for "à-la-carte" reconstructions of genome-scale metabolic models

Méziane Aite , Marie Chevallier , Clémence Frioux , Camille Trottier , Jeanne Got
PLoS Computational Biology, 2018, 14 (5), pp.e1006146. ⟨10.1371/journal.pcbi.1006146⟩
Journal articles hal-01807842v1
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NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding

Konstantin Khalturin , Isabelle M.L. Billas , Yassmine Chebaro , Adam M. Reitzel , Ann M. Tarrant
Journal of Steroid Biochemistry and Molecular Biology, 2018, 184, pp.11-19. ⟨10.1016/j.jsbmb.2018.06.014⟩
Journal articles hal-02017750v1
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Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen

Gabriel Markov , Juliana Gutierrez-Mazariegos , Delphine Pitrat , Isabelle M. L. Billas , François Bonneton
Science Advances , 2017, 3 (3), pp.e1601778. ⟨10.1126/sciadv.1601778⟩
Journal articles hal-01693173v1
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On the origin and evolutionary history of NANOG

Pierluigi Scerbo , Gabriel V Markov , Céline Vivien , Laurent Kodjabachian , Barbara Demeneix
PLoS ONE, 2014, 9 (1), pp.e85104. ⟨10.1371/journal.pone.0085104⟩
Journal articles hal-01111124v1
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Ventx factors function as Nanog-like guardians of developmental potential in Xenopus

Pierluigi Scerbo , Fabrice Girardot , Céline Vivien , Gabriel V Markov , Guillaume Luxardi
PLoS ONE, 2012, 7 (5), pp.e36855. ⟨10.1371/journal.pone.0036855⟩
Journal articles hal-00843463v1

Evolution of Nuclear Retinoic Acid Receptor Alpha (RAR alpha) Phosphorylation Sites. Serine Gain Provides Fine-Tuned Regulation

Eric Samarut , Ismail Amal , Gabriel Markov , Roland Stote , Annick Dejaegere
Molecular Biology and Evolution, 2011, 28 (7), pp.2125 - 2137. ⟨10.1093/molbev/msr035⟩
Journal articles hal-02645447v1

Origin and evolution of the ligand-binding ability of nuclear receptors

Gabriel Markov , Vincent Laudet
Molecular and Cellular Endocrinology, 2011, 334 (1-2), pp.21 - 30. ⟨10.1016/j.mce.2010.10.017⟩
Journal articles hal-02648059v1

Independent elaboration of steroid hormone signaling pathways in metazoans

Gabriel V Markov , Raquel Tavares , Chantal Dauphin-Villemant , Barbara A. Demeneix , Michael E. Baker
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (29), pp.11913-11918. ⟨10.1073/pnas.0812138106⟩
Journal articles hal-02666864v1

Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita

Pierre Abad , Jerome Gouzy , Jean-Marc Aury , Philippe Castagnone-Sereno , Etienne Danchin
Nature Biotechnology, 2008, 26 (8), pp.909-915. ⟨10.1038/nbt.1482⟩
Journal articles hal-01189285v1
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The evolution of the ligand/receptor couple: a long road from comparative endocrinology to comparative genomics

Gabriel V Markov , Mathilde Paris , Stephanie Bertrand , Vincent Laudet
Molecular and Cellular Endocrinology, 2008, 293 (1-2), pp.5. ⟨10.1016/j.mce.2008.06.011⟩
Journal articles hal-00532041v1

The "street light syndrome", or how protein taxonomy can bias experimental manipulations

Gabriel Markov , Guillaume Lecointre , Barbara Demeneix , Vincent Laudet
BioEssays, 2008, 30 (4), pp.349-357. ⟨10.1002/bies.20730⟩
Journal articles hal-02662543v1

Evolution of nuclear receptors in insects

François Bonneton , Arnaud Chaumot , T. Iwema , I. Billas , D. Moras
18th International Ecdysone Workshop 2010, Jul 2010, Ceske Budejovice, Czech Republic. pp.1
Conference papers hal-02593438v1
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Evolution of Hormonal Mechanisms

Vincent Laudet , Gabriel V. Markov
Encyclopedia of Endocrine Diseases, Second Edition, 2018, 978-0-12-812200-6. ⟨10.1016/B978-0-12-812199-3.64198-1⟩
Book sections hal-03941018v1
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Evolution of Steroid Signaling in Metazoans

Gabriel Markov
Agricultural sciences. Ecole normale supérieure de lyon - ENS LYON, 2011. English. ⟨NNT : 2011ENSL0634⟩
Theses tel-01373637v1