Gwendal Lazennec

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Documents

Présentation

Directeur de recherche CNRS

Responsable de l'équipe: Chimiokines, microenvironnement et inflammation

Membre du comité de pilotage du GDR 3697 "Micronit" (Microenvironnement des niches tumorales) et co-responsable de l'axe "Biomarkers and therapeutic targeting of tumor niches".

Adresse prof.: CNRS UMR 9005 Sys2Diag
"Modélisation et Ingénierie des systèmes complexes biologiques pour le diagnostic"
Cap delta, 1682 rue de la Valsière, 34184 Montpellier Cedex 4, France

Web: https://gwendal-lazennec.fr/

Domaines de recherche

Cancer

Publications

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Publications

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CXCR2 chemokine receptor -a master regulator in cancer and physiology

Gwendal Lazennec , Krishna Rajarathnam , Ann Richmond
Trends in Molecular Medicine, 2024, 30 (1), pp.37-55. ⟨10.1016/j.molmed.2023.09.003⟩
Article dans une revue hal-04403865 v1
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WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

Adrienne Anginot , Julie Nguyen , Zeina Abou Nader , Vincent Rondeau , Amélie Bonaud et al.
Nature Communications, 2023, 14 (1), pp.2058. ⟨10.1038/s41467-023-37791-4⟩
Article dans une revue hal-04077290 v1
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Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer

Colleen Sweeney , Gwendal Lazennec , Christoph Vogel
Frontiers in Pharmacology, 2022, 13, pp.1095289. ⟨10.3389/fphar.2022.1095289⟩
Article dans une revue hal-03918758 v1
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CXCR2 intrinsically drives the maturation and function of neutrophils in mice

Pauline Delobel , Benjamin Ginter , Eliane Rubio , Karl Balabanian , Gwendal Lazennec
Frontiers in Immunology, 2022
Article dans une revue hal-03798339 v1

Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer

Colin Timaxian , Christoph Vogel , Charlotte Orcel , Diana Vetter , Camille Durochat et al.
Cancers, 2021, 13 (11), pp.2584. ⟨10.3390/cancers13112584⟩
Article dans une revue hal-04310542 v1
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CXCR2 Levels Correlate with Immune Infiltration and a Better Prognosis of Triple-Negative Breast Cancers

Florence Boissière-Michot , William Jacot , Océane Massol , Caroline Mollevi , Gwendal Lazennec
Cancers, 2021, 13 (10), pp.2328. ⟨10.3390/cancers13102328⟩
Article dans une revue hal-03236436 v1
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Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer

Colin Timaxian , Christoph F A Vogel , Charlotte Orcel , Diana Vetter , Camille Durochat et al.
Cancers, 2021, 13 (11), pp.2584. ⟨10.3390/cancers13112584⟩
Article dans une revue hal-03236738 v1
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Targeting the aryl hydrocarbon receptor signaling pathway in breast cancer development

Christoph Vogel , Gwendal Lazennec , Sarah y Kado , Carla Dahlem , Yi He et al.
Frontiers in Immunology, 2021, 12, pp.625346. ⟨10.3389/fimmu.2021.625346⟩
Article dans une revue hal-03186946 v1
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Prognostic Value of CXCR2 in Breast Cancer

Florence Boissière-Michot , William Jacot , Julien Fraisse , Sophie Gourgou , Colin Timaxian et al.
Cancers, 2020, 12 (8), pp.2076. ⟨10.3390/cancers12082076⟩
Article dans une revue hal-02914978 v1
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The health status alters the pituitary function and reproduction of mice in a Cxcr2 -dependent manner

Colin Timaxian , Isabelle Raymond-Letron , Céline Bouclier , Linda Gulliver , Ludovic Le Corre et al.
Life Science Alliance, 2020, 3 (3), pp.e201900599. ⟨10.26508/lsa.201900599⟩
Article dans une revue hal-02476814 v1
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Recent discoveries concerning the tumor - mesenchymal stem cell interactions

Gwendal Lazennec , Paula Lam
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2016, 1866 (2), pp.290-299. ⟨10.1016/j.bbcan.2016.10.004⟩
Article dans une revue hal-02146513 v1
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Polycyclic Aromatic Hydrocarbons Reciprocally Regulate IL-22 and IL-17 Cytokines in Peripheral Blood Mononuclear Cells from Both Healthy and Asthmatic Subjects

Coline Plé , Ying Fan , Saliha Ait Yahia , Han Vorng , Laetitia Everaere et al.
PLoS ONE, 2015, 10 (4), pp.e0122372. ⟨10.1371/journal.pone.0122372⟩
Article dans une revue hal-02146525 v1
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Polycyclic Aromatic Hydrocarbons promote Th22 polarization by reciprocally regulating IL-22 and IL- 17

Coline Ple , Ying Fan , Saliha Ait Yahia , Han Vorng , Laetitia Everaere et al.
PLoS ONE, 2015, 10 (4), pp.e0122372. ⟨10.1371/journal.pone.0122372⟩
Article dans une revue hal-03002029 v1
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IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production

Pauline Escobar , Céline Bouclier , Julien Serret , Ivan Bièche , Madly Brigitte et al.
Oncotarget, 2015, 6 (30), pp.29034-29047. ⟨10.18632/oncotarget.4732⟩
Article dans une revue hal-02146528 v1
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Characterization of an adaptive immune response in microsatellite-instable colorectal cancer

Florence Boissière-Michot , Gwendal Lazennec , Hélène Frugier , Marta Jarlier , Lise Roca et al.
OncoImmunology, 2014, 3 (6), pp.e29256. ⟨10.4161/onci.29256⟩
Article dans une revue hal-02146604 v1

Chromatin remodeling protein SMAR1 regulates NF-κB dependent Interleukin-8 transcription in breast cancer

Sunil Malonia , Bhawna Yadav , Surajit Sinha , Gwendal Lazennec , Samit Chattopadhyay
International Journal of Biochemistry and Cell Biology, 2014, 55, pp.220-226. ⟨10.1016/j.biocel.2014.09.008⟩
Article dans une revue hal-02146532 v1
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Estrogen receptor signaling as a target for novel breast cancer therapeutics

Jack-Michel Renoir , Véronique Marsaud , Gwendal Lazennec
Biochemical Pharmacology, 2013, 85 (4), pp.449-465. ⟨10.1016/j.bcp.2012.10.018⟩
Article dans une revue hal-03002141 v1
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Estrogen receptor signaling as a target for novel breast cancer therapeutics.

Jack-Michel Renoir , Véronique Marsaud , Gwendal Lazennec
Biochemical Pharmacology, 2013, 85 (4), pp.449-65. ⟨10.1016/j.bcp.2012.10.018⟩
Article dans une revue inserm-00758201 v1

Le PAIR-gynécologie: Recherche multi/interdisciplinaire en cancérologie gynécologique. Les problèmes à résoudre en 2012

Isabelle Ray-Coquard , Franck Chauvin , Éric Leblanc , Christophe Caux , Hélène Hoarau et al.
Bulletin du Cancer, 2012, 99 (4), pp.479-498. ⟨10.1684/bdc.2012.1558⟩
Article dans une revue halshs-00785750 v1

[PAIR-gynaecology: multi/interdisciplinary for gynecologic cancer research. Problems needed to be resolved].

Isabelle Ray-Coquard , Franck Chauvin , Eric Leblanc , Christophe Caux , Hélène Hoarau et al.
Bulletin du Cancer, 2012, 99 (4), pp.479-98. ⟨10.1684/bdc.2012.1558⟩
Article dans une revue hal-00723410 v1
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Potential Role of Estrogen Receptor Beta as a Tumor Suppressor of Epithelial Ovarian Cancer

Carine Bossard , Muriel Busson , David Vindrieux , Françoise Gaudin , Véronique Machelon et al.
PLoS ONE, 2012, 7 (9), pp.e44787. ⟨10.1371/journal.pone.0044787⟩
Article dans une revue hal-03002049 v1

Coxsackie and adenovirus receptor is a target and a mediator of estrogen action in breast cancer.

David Vindrieux , Ludovic Le Corre , Jer-Tsong Hsieh , Raphaël Métivier , Pauline Escobar et al.
Endocrine-Related Cancer, 2011, 18 (3), pp.311-21. ⟨10.1530/ERC-10-0230⟩
Article dans une revue hal-01117400 v1
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Functional integration of the Ah receptor with RelB and IL-8 confers the pro-survival advantage to mammary epithelial cells of inflammatory breast tumors

Christoph Franz Adam Vogel , Wen Li , Dalei Wu , Jamie K. Miller , Colleen Sweeney et al.
Archives of Biochemistry and Biophysics, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩
Article dans une revue hal-03002041 v1
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Coxsackie and adenovirus receptor is a target and a mediator of estrogen action in breast cancer

David Vindrieux , Ludovic Le Corre , Jer-Tsong Hsieh , Raphaël Métivier , Pauline Escobar et al.
Endocrine-Related Cancer, 2011, 18 (3), pp.311-321. ⟨10.1530/ERC-10-0230⟩
Article dans une revue hal-03002183 v1
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Functional integration of the Ah receptor with RelB and IL-8 confers the pro-survival advantage to mammary epithelial cells of inflammatory breast tumors

Christoph Franz Adam Vogel , Wen Li , Dalei Wu , Jamie Miller , Colleen Sweeney et al.
Archives of Biochemistry and Biophysics, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩
Article dans une revue hal-03002191 v1
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Chemokines and their receptors: new insights in cancer inflammation

Gwendal Lazennec , Ann Richmond
Trends in Molecular Medicine, 2010, 16 (3), pp.133-144. ⟨10.1016/j.molmed.2010.01.003⟩
Article dans une revue hal-03002095 v1

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance

C. Chavey , Gwendal Lazennec , S. Lagarrigue , C. Clape , I. Iankova et al.
Cell Metabolism, 2009, 9 (4), pp.339--49. ⟨10.1016/j.cmet.2009.03.002⟩
Article dans une revue hal-02194094 v1
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CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.

Carine Chavey , Gwendal Lazennec , Sylviane Lagarrigue , Cyrielle Clapé , Irena Iankova et al.
Cell Metabolism, 2009, 9 (4), pp.339-49. ⟨10.1016/j.cmet.2009.03.002⟩
Article dans une revue inserm-00375507 v2
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Concise review: adult multipotent stromal cells and cancer: risk or benefit?

Gwendal Lazennec , Christian Jorgensen
Stem Cells / Stem Cells (Miamisburg), 2008, 26 (6), pp.1387-94. ⟨10.1634/stemcells.2007-1006⟩
Article dans une revue inserm-00271551 v1
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Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta.

Nathalie Picard , Catherine Charbonneau , Mélanie Sanchez , Anne Licznar , Muriel Busson et al.
Molecular Endocrinology -Baltimore-, 2008, 22 (2), pp.317-30. ⟨10.1210/me.2007-0281⟩
Article dans une revue inserm-00268259 v1
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Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer.

Carine Chavey , Marcus Muhlbauer , Carine Bossard , Ariane Freund , Sebastien Durand et al.
Molecular Pharmacology, 2008, 74 (5), pp.1359-66. ⟨10.1124/mol.108.047332⟩
Article dans une revue inserm-00308891 v1
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CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation.

Claudia Amura , Kelley Brodsky , Berenice Gitomer , Kim Mcfann , Gwendal Lazennec et al.
American Journal of Physiology - Cell Physiology, 2008, 294 (3), pp.C786-96. ⟨10.1152/ajpcell.00457.2007⟩
Article dans une revue inserm-00268266 v1

High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors.

D. Marot , I. Bieche , C. Aumas , S. Esselin , C. Bouquet et al.
Endocrine-Related Cancer, 2007, 14 (3), pp.691-702. ⟨10.1677/ERC-07-0012⟩
Article dans une revue hal-00171094 v1

High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors.

D. Marot , I. Bieche , C. Aumas , S. Esselin , C. Bouquet et al.
Endocrine-Related Cancer, 2007, 14 (3), pp.691-702
Article dans une revue hal-00177513 v1
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Chemokines: novel targets for breast cancer metastasis.

Simi Ali , Gwendal Lazennec
CANCER AND METASTASIS REVIEW, 2007, 26 (3-4), pp.401-420. ⟨10.1007/s10555-007-9073-z⟩
Article dans une revue inserm-00168311 v1
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Oestrogen receptor negative breast cancers exhibit high cytokine content.

Carine Chavey , Frédéric Bibeau , Sophie Gourgou-Bourgade , Sandrine Burlinchon , Florence Boissière et al.
Breast Cancer Research, 2007, 9 (1), pp.R15. ⟨10.1186/bcr1648⟩
Article dans une revue inserm-00143810 v1
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RelB, a new partner of aryl hydrocarbon receptor-mediated transcription.

Christoph F. A. Vogel , Eric Sciullo , Wen Li , Pat Wong , Gwendal Lazennec et al.
Molecular Endocrinology -Baltimore-, 2007, 21 (12), pp.2941-55. ⟨10.1210/me.2007-0211⟩
Article dans une revue inserm-00268250 v1
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Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells.

Corinne Henriquet , Claire Gougat , Audrey Combes , Gwendal Lazennec , Marc Mathieu
Lung Cancer, 2007, 56 (2), pp.167-74. ⟨10.1016/j.lungcan.2006.12.003⟩
Article dans une revue inserm-00143972 v1
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CXC chemokines located in the 4q21 region are up-regulated in breast cancer.

Ivan Bièche , Carine Chavey , Catherine Andrieu , Muriel Busson , Sophie Vacher et al.
Endocrine-Related Cancer, 2007, 14 (4), pp.1039-1052. ⟨10.1677/erc.1.01301⟩
Article dans une revue inserm-00153602 v1

Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus

M a J Hervé , G Meduri , F G Petit , T S Domet , Gwendal Lazennec et al.
Journal of Endocrinology, 2006, 188 (1), pp.91-99. ⟨10.1677/joe.1.06184⟩
Article dans une revue hal-02441847 v1
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Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis.

Gwendal Lazennec
Cancer Letters, 2006, 231 (2), pp.151-7. ⟨10.1016/j.canlet.2005.01.021⟩
Article dans une revue inserm-00143901 v1
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ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors.

Vanessa Duong , Anne Licznar , Raphaël Margueron , Nathalie Boulle , Muriel Busson et al.
Oncogene, 2006, 25 (12), pp.1799-806. ⟨10.1038/sj.onc.1209102⟩
Article dans une revue inserm-00143967 v1
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The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.

Jean-Sébastien Annicotte , Carine Chavey , Nadège Servant , Jacques Teyssier , Aurélie Bardin et al.
Oncogene, 2005, 24 (55), pp.8167-75. ⟨10.1038/sj.onc.1208950⟩
Article dans une revue inserm-00144663 v1
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Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis.

Jennifer Cheng , Eun Jig Lee , Laird D. Madison , Gwendal Lazennec
FEBS Letters, 2004, 566 (1-3), pp.169-72. ⟨10.1016/j.febslet.2004.04.025⟩
Article dans une revue inserm-00143968 v1
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Mechanisms underlying differential expression of interleukin-8 in breast cancer cells.

Ariane Freund , Valérie Jolivel , Sébastien Durand , Nathalie Kersual , Dany Chalbos et al.
Oncogene, 2004, 23 (36), pp.6105-14. ⟨10.1038/sj.onc.1207815⟩
Article dans une revue inserm-00143639 v1
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Loss of ERbeta expression as a common step in estrogen-dependent tumor progression.

Allison Bardin , Nathalie Boulle , Gwendal Lazennec , Françoise Vignon , Pascal Pujol
Endocrine-Related Cancer, 2004, 11 (3), pp.537-51
Article dans une revue inserm-00153815 v1
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Identification of genes involved in growth inhibition of breast cancer cells transduced with estrogen receptor.

Anne Licznar , Simona Caporali , Annick Lucas , Alessandro Weisz , Françoise Vignon et al.
FEBS Letters, 2003, 553 (3), pp.445-50
Article dans une revue inserm-00143969 v1
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Comparative transductions of breast cancer cells by three DNA viruses.

Annick Lucas , Eric J. Kremer , Silvio Hemmi , José Luis , Françoise Vignon et al.
Biochemical and Biophysical Research Communications, 2003, 309 (4), pp.1011-6. ⟨10.1016/j.bbrc.2003.08.101⟩
Article dans une revue inserm-00143970 v1
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IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells.

Ariane Freund , Corine Chauveau , Jean-Paul Brouillet , Annick Lucas , Matthieu Lacroix et al.
Oncogene, 2003, 22 (2), pp.256-65. ⟨10.1038/sj.onc.1206113⟩
Article dans une revue inserm-00143840 v1
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Involvement of cyclic AMP response element binding protein (CREB) and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators.

Gwendal Lazennec , James P. Thomas , Benita S. Katzenellenbogen
Journal of Steroid Biochemistry and Molecular Biology, 2001, 77 (4-5), pp.193-203
Article dans une revue inserm-00143971 v1
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ER beta inhibits proliferation and invasion of breast cancer cells.

Gwendal Lazennec , Damien Bresson , Annick Lucas , Corine Chauveau , Françoise Vignon
Endocrinology, 2001, 142 (9), pp.4120-30
Article dans une revue inserm-00153812 v1
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Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.

Gwendal Lazennec , Laurence Canaple , Damien Saugy , Walter Wahli
Molecular Endocrinology -Baltimore-, 2000, 14 (12), pp.1962-75
Article dans une revue inserm-00153813 v1

Regulation of gene expression and biological activity of rainbow trout estrogen receptor

F. Pakdel , F. Delaunay , B. Ducouret , G. Flouriot , L. Kern et al.
Fish Physiology and Biochemistry, 1997, 17 (1/6), pp.123-133. ⟨10.1023/A:1007706207857⟩
Article dans une revue istex hal-02442869 v1

The sheep estrogen receptor : cloning and regulation of expression in the hypothalamo-pituitary axis

T. Madigou , C. Tiffoche , Gwendal Lazennec , Julien Pelletier , M.L. Thieulant
Molecular and Cellular Endocrinology, 1996, 121, pp.153-163
Article dans une revue hal-02690364 v1