Accéder directement au contenu

Henrik Toft Simonsen

Professor and Director of the Laboratory. Laboratoire Biotechnologies Végétales plantes aromatiques et médicinales (BVpam) Faculté des Sciences et Techniques, Université Jean Monnet
34
Documents
Affiliations actuelles
  • 1075130
Identifiants chercheurs
Contact

Présentation

Still working with Plant Biochemistry, and Biotechnology. Our research is focused on understanding the biochemistry of terpenoids, especially smaller volatile terpenoids that are used for commercial products like perfumes and drugs. We also aim at generating novel plants (e.g. mosses) to produce these compounds at large scale. Our engineering efforts will employ techniques from the fields of synthetic biology, genomics, transcriptomics, proteomics, and metabolomics. Get in touch if you want to work or collaborate with us. The work on mosses led to the establishment of Mosspiration Biotech ApS, and later Patch Botanics. Both are now closed, but the path was good. Lately, we have started a new company Tailwind Biotech that commercialises a patent on the use of machine learning to design DNA. Specialties: Plant biochemistry, pharmacy, medicinal chemistry, Metabolomics, Entrepreneurship,

Domaines de recherche


Compétences

Biotechnology Synthetic Biology Plant Biochemistry

Publications

Genome analysis of Chlorella vulgaris (CCAP 211/12) mutants provided insight into the molecular basis of chlorophyll deficiency

Jianbo Jian , Pablo Torres-Montero , Mingzhou Bai , Yi Lu , Henrik Toft Simonsen
Algal Research - Biomass, Biofuels and Bioproducts, 2024, 78, pp.103426. ⟨10.1016/j.algal.2024.103426⟩
Article dans une revue hal-04502869v1

Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds

Shiming Li , Tsan-Yu Chiu , Xin Jin , Dong Cao , Meng Xu
Communications Biology, 2023, 6 (1), pp.1198. ⟨10.1038/s42003-023-05569-5⟩
Article dans une revue hal-04502859v1

Lipidomes of Icelandic bryophytes and screening of high contents of polyunsaturated fatty acids by using lipidomics approach

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Nils Cronberg , Henrik Toft Simonsen
Phytochemistry, 2023, 206, pp.113560. ⟨10.1016/j.phytochem.2022.113560⟩
Article dans une revue hal-04503125v1

Dietary non-starch polysaccharides impair immunity to enteric nematode infection

Angela Valente , Karen Jensen , Laura Myhill , Ling Zhu , Caroline Mentzel
BMC Biology, 2023, 21 (1), pp.138. ⟨10.1186/s12915-023-01640-z⟩
Article dans une revue hal-04503081v1
Image document

Anti-Inflammatory Activity of Bryophytes Extracts in LPS-Stimulated RAW264.7 Murine Macrophages

Raíssa Volpatto Marques , Stefania Enza Sestito , Frédéric Bourgaud , Sissi Miguel , Frédéric Cailotto
Molecules, 2022, 27 (6), pp.1940. ⟨10.3390/molecules27061940⟩
Article dans une revue hal-03652855v1

Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi

Miguel Peña-Espinoza , Yeambell Romero-Uzqueda , Angela Valente , Matthew de Roode , Henrik Toft Simonsen
International journal for parasitology. Drugs and drug resistance, 2022, 20 (6), pp.43-53. ⟨10.1016/j.ijpddr.2022.08.002⟩
Article dans une revue hal-04503144v1

Lipidomic analysis of moss species Bryum pseudotriquetrum and Physcomitrium patens under cold stress

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Henrik Toft Simonsen
Plant-Environment Interactions, 2022, 3 (6), pp.254-263. ⟨10.1002/pei3.10095⟩
Article dans une revue hal-04503150v1

Identification of compounds responsible for the anthelmintic effects of chicory (Cichorium intybus) by molecular networking and bio-guided fractionation

Angela Valente , Matthew de Roode , Madeleine Ernst , Miguel Peña-Espinoza , Louis Bornancin
International journal for parasitology. Drugs and drug resistance, 2021, 15, pp.105-114. ⟨10.1016/j.ijpddr.2021.02.002⟩
Article dans une revue hal-04503390v1

Effects of extraction parameters on lipid profiling of mosses using UPLC-ESI-QTOF-MS and multivariate data analysis

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Henrik Toft Simonsen
Metabolomics, 2021, 17 (11), pp.96. ⟨10.1007/s11306-021-01847-7⟩
Article dans une revue hal-04503355v1

Collagenase and Tyrosinase Inhibitory Effect of Isolated Constituents from the Moss Polytrichum formosum

Raíssa Volpatto Marques , Agnès Guillaumin , Ahmed Abdelwahab , Aleksander Salwinski , Charlotte Gotfredsen
Plants, 2021, 10 (7), pp.1271. ⟨10.3390/plants10071271⟩
Article dans une revue hal-04503369v1

Identification of anti-parasitic agents in Cichorium intybus.

A Valente , M de Roode , M Peña-Espinoza , L Bornancin , Henrik Toft Simonsen
Planta Medica, 2021, 87, pp.1266. ⟨10.1055/s-0041-1736835⟩
Article dans une revue hal-04503348v1

Natural Products from Bryophytes: From Basic Biology to Biotechnological Applications

Armin Horn , Arnaud Pascal , Isidora Lončarević , Raíssa Volpatto Marques , Yi Lu
Critical Reviews in Plant Sciences, 2021, 40 (3), pp.191-217. ⟨10.1080/07352689.2021.1911034⟩
Article dans une revue hal-04503375v1

Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds

Charlotte Smith Bonde , Louis Bornancin , Yi Lu , Henrik Toft Simonsen , María Martínez-Valladares
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.674520⟩
Article dans une revue hal-04503384v1

Cellulase and Macerozyme-PEG-mediated Transformation of Moss Protoplasts

Rituraj Batth , Ilenuta Simina Cuciurean , Satish Kumar Kodiripaka , Sarah Rothman , Caroline Greisen
Bio-protocol , 2020, 10 (21), ⟨10.21769/BioProtoc.3782⟩
Article dans une revue hal-04503414v1

Exploring evolutionary theories of plant defence investment using field populations of the deadly carrot

Karen Martinez-Swatson , Rasmus Kjøller , Federico Cozzi , Henrik Toft Simonsen , Nina Rønsted
Annals of Botany, 2020, 125 (5), pp.737-750. ⟨10.1093/aob/mcz151⟩
Article dans une revue hal-04504043v1

Connecting moss lipid droplets to patchoulol biosynthesis

Anantha Peramuna , Hansol Bae , Carmen Quiñonero López , Arvid Fromberg , Bent Petersen
PLoS ONE, 2020, 15 (12), pp.e0243620. ⟨10.1371/journal.pone.0243620⟩
Article dans une revue hal-04504029v1

Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

Camilla Knudsen , Krutika Bavishi , Ketil Mathiasen Viborg , Damian Paul Drew , Henrik Toft Simonsen
Phytochemistry, 2020, 170, pp.112214. ⟨10.1016/j.phytochem.2019.112214⟩
Article dans une revue hal-04504047v1

Biosynthesis and Industrial Production of Androsteroids

Rituraj Batth , Clément Nicolle , Ilenuta Simina Cuciurean , Henrik Toft Simonsen
Plants, 2020, 9 (9), pp.1144. ⟨10.3390/plants9091144⟩
Article dans une revue hal-04504039v1

Thapsigargins and induced chemical defence in Thapsia garganica

Karen Martinez-Swatson , Carmen Quiñonero-López , Madeleine Ernst , Nina Rønsted , Christopher James Barnes
Chemoecology, 2020, 30 (5), pp.255-267. ⟨10.1007/s00049-020-00315-3⟩
Article dans une revue hal-04504033v1

Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

Miguel Peña-Espinoza , Angela Valente , Louis Bornancin , Henrik Toft Simonsen , Stig Thamsborg
Veterinary Parasitology, 2020, 280, pp.109088. ⟨10.1016/j.vetpar.2020.109088⟩
Article dans une revue hal-04504044v1

Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Nur Kusaira Binti Khairul Ikram , Arman Beyraghdar , Anantha Peramuna , Alexander R. van der Krol , Harro Bouwmeester
Molecules, 2019, 24 (21), pp.3822. ⟨10.3390/molecules24213822⟩
Article dans une revue hal-04504534v1

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Trine Bundgaard Andersen , Silas Anselm Rasmussen , Søren Brøgger Christensen , Henrik Toft Simonsen
Phytochemistry, 2019, 157, pp.168-174. ⟨10.1016/j.phytochem.2018.10.027⟩
Article dans une revue hal-04504542v1

Valuable Fatty Acids in Bryophytes—Production, Biosynthesis, Analysis and Applications

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Henrik Toft Simonsen
Plants, 2019, 8 (11), pp.524. ⟨10.3390/plants8110524⟩
Article dans une revue hal-04504054v1

Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L.

Madeleine Ernst , Louis-Félix Nothias , Justin van der Hooft , Ricardo Silva , C. Haris Saslis-Lagoudakis
Frontiers in Plant Science, 2019, 10, ⟨10.3389/fpls.2019.00846⟩
Article dans une revue hal-04504539v1

Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture

Ian David Woolsey , Angela Valente , Andrew Williams , Stig Thamsborg , Henrik Simonsen
Scientific Reports, 2019, 9 (1), pp.20414. ⟨10.1038/s41598-019-56619-0⟩
Article dans une revue hal-04504048v1

In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries

Bjørn Dueholm , Damian Drew , Crystal Sweetman , Henrik Simonsen
Planta, 2018, 249 (1), pp.59-70. ⟨10.1007/s00425-018-2986-7⟩
Article dans une revue hal-04504526v1
Image document

In vivo assembly of DNA-fragments in the moss, Physcomitrella patens

Brian Christopher King , Konstantinos Vavitsas , Nur Kusaira Binti Khairul Ikram , Josephine Schrøder , Lars B. Scharff
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep25030⟩
Article dans une revue hal-02885735v1
Image document

Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily

Bjorn Dueholm , Celia Krieger , Damian Drew , Alexandre Olry , Tsunashi Kamo
BMC Evolutionary Biology, 2015, 15, ⟨10.1186/s12862-015-0396-z⟩
Article dans une revue hal-01475932v1
Image document

In vitro screening of Indian medicinal plants for antiplasmodial activity

Henrik Toft Simonsen , Jesper Brændegaard Nordskjold , Ulla Wagner Smitt , Ulf Nyman , Pushpangadan Palpu
Journal of Ethnopharmacology, 2001, 74 (2), pp.195-204. ⟨10.1016/S0378-8741(00)00369-X⟩
Article dans une revue hal-04502853v1

Extracts from the Liverwort Bazzania trilobata with Potential Dermo-cosmetic Properties

Raíssa Volpatto Marques , Aleksander Salwinski , Kasper Enemark-Rasmussen , Charlotte Gotfredsen , Yi Lu
Bioactive Compounds in Bryophytes and Pteridophytes, Springer International Publishing, pp.147-164, 2023, Reference Series in Phytochemistry, ⟨10.1007/978-3-031-23243-5_9⟩
Chapitre d'ouvrage hal-04246885v1

Overexpression of Physcomitrium patens cell cycle regulators leads to larger gametophytes

Anantha Peramuna , Carmen Quiñonero López , Francisco Javier Astorga Rios , Hansol Bae , Jonatan Ulrik Fangel
Bioactive Compounds in Bryophytes and Pteridophytes, 13 (1), Springer International Publishing, pp.4301, 2023, Reference Series in Phytochemistry, ⟨10.1038/s41598-023-31417-x⟩
Chapitre d'ouvrage hal-04503118v1

From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development

Søren Brøgger Christensen , Henrik Toft Simonsen , Nikolai Engedal , Poul Nissen , Jesper Vuust Møller
Progress in the Chemistry of Organic Natural Products 115, 115, Springer International Publishing, pp.59-114, 2021, Progress in the Chemistry of Organic Natural Products, ⟨10.1007/978-3-030-64853-4_2⟩
Chapitre d'ouvrage hal-04503397v1

Developments and Perspectives in Bryophyte Biotechnology in Sub-Saharan Africa

Kenneth Yongabi Anchang , Henrik Toft Simonsen
Biotechnology and Bioengineering, IntechOpen, 2019, ⟨10.5772/intechopen.81692⟩
Chapitre d'ouvrage hal-04504523v1