Henrik Toft Simonsen

Professor and Director of the Laboratory. Laboratoire Biotechnologies Végétales plantes aromatiques et médicinales (BVpam) Faculté des Sciences et Techniques, Université Jean Monnet
63 %
Libre accès
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Documents
Affiliation actuelle
  • Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales (BVPAM)
Identifiants chercheurs
Contact

Présentation

Still working with Plant Biochemistry, and Biotechnology.

Our research is focused on understanding the biochemistry of terpenoids, especially smaller volatile terpenoids that are used for commercial products like perfumes and drugs. We also aim at generating novel plants (e.g. mosses) to produce these compounds at large scale. Our engineering efforts will employ techniques from the fields of synthetic biology, genomics, transcriptomics, proteomics, and metabolomics. Get in touch if you want to work or collaborate with us.

The work on mosses led to the establishment of Mosspiration Biotech ApS, and later Patch Botanics. Both are now closed, but the path was good. Lately, we have started a new company Tailwind Biotech that commercialises a patent on the use of machine learning to design DNA.

Specialties: Plant biochemistry, pharmacy, medicinal chemistry, Metabolomics, Entrepreneurship,


Compétences

Biotechnology Synthetic Biology Plant Biochemistry

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Publications

Beyond Tanacetum cinerariifolium: Advances in Pyrethrins Biosynthesis and Prospects for Engineered Cell Factories

Francisco Javier Astorga Ríos , Henrik Toft Simonsen

Molecular Biotechnology, 2026, ⟨10.1007/s12033-025-01549-8⟩

Article dans une revue hal-05453963v1

The telomere‐to‐telomere genome of Sanicula chinensis unveils genetic underpinnings of low furanocoumarin diversity and content in one basal lineage of Apiaceae

Weijun He , Donghua Hu , Miaoxian Guo , Bao Nie , Guangpu Zhang et al.

The Plant Journal, 2025, 123 (1), ⟨10.1111/tpj.70311⟩

Article dans une revue hal-05147341v1

Genome sequencing of three Polyscias species reveals common features in terpene synthase gene family evolution in these species

Mingzhou Bai , Xin Yang , David Lorence , Kenneth Wood , Natalie Iwanycki Ahlstrand et al.

Plant Genome, 2025, 18 (1), ⟨10.1002/tpg2.20563⟩

Article dans une revue hal-04984426v1

Production of the monoterpenoid acid moiety of pyrethrins, trans-chrysanthemol, in the moss Physcomitrium patens

Francisco Javier Astorga Ríos , Benoît Boachon , Henrik Toft Simonsen

Plant Biotechnology Reports, 2025, ⟨10.1007/s11816-025-00980-2⟩

Article dans une revue hal-05072581v1

Characterization of microbial type terpene synthases from two liverworts Lophocolea bidentata and Nardia scalaris.

Corentin Conart , Benjamin Svejdal Bejder , Mikkel Schardelmann , Rituraj Batth , Satish Kumar Kodiripaka et al.

Plant Physiology and Biochemistry, 2025, pp.110031. ⟨10.1016/j.plaphy.2025.110031⟩

Article dans une revue hal-05072586v1

Tamariscol biosynthesis in Frullania tamarisci

Corentin Conart , Henrik Toft Simonsen

Phytochemistry, 2025, 229, pp.114301. ⟨10.1016/j.phytochem.2024.114301⟩

Article dans une revue hal-04820165v1

Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors

Paul Alexander Niederau , Maria Caroline Weilguny , Sarah Chamas , Caitlin Elizabeth Turney , Juliana Parsons et al.

Plant Cell Reports, 2025, 44 (10), pp.216. ⟨10.1007/s00299-025-03602-x⟩

Article dans une revue hal-05267012v1

Transcriptional and functional characterization in the terpenoid precursor pathway of the early land plant Physcomitrium patens

A. Horn , Y. Lu , F. Astorga Ríos , Henrik Toft Simonsen , J. Becker

Plant Biology, 2024, ⟨10.1111/plb.13741⟩

Article dans une revue hal-04820155v1

Genome analysis of Chlorella vulgaris (CCAP 211/12) mutants provided insight into the molecular basis of chlorophyll deficiency

Jianbo Jian , Pablo Torres-Montero , Mingzhou Bai , Yi Lu , Henrik Toft Simonsen

Algal Research - Biomass, Biofuels and Bioproducts, 2024, 78, pp.103426. ⟨10.1016/j.algal.2024.103426⟩

Article dans une revue hal-04502869v1

The telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

Mingzhou Bai , Sanjie Jiang , Shanshan Chu , Yangyang Yu , Dai Shan et al.

GigaScience, 2024, 13, ⟨10.1093/gigascience/giae025⟩

Article dans une revue hal-04694744v1
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Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds

Shiming Li , Tsan-Yu Chiu , Xin Jin , Dong Cao , Meng Xu et al.

Communications Biology, 2023, 6 (1), pp.1198. ⟨10.1038/s42003-023-05569-5⟩

Article dans une revue hal-04502859v1

Heterologous Production of Artemisinin in <em>Physcomitrium patens</em> by Direct in vivo Assembly of Multiple DNA Fragments

Nur Ikram , Ali Zakariya , Mohd Saiman , Arman Kashkooli , Henrik Simonsen

Bio-protocol , 2023, 13 (14), ⟨10.21769/BioProtoc.4719⟩

Article dans une revue hal-04503073v1

Current state, strategies, and perspectives in enhancing artemisinin production

Ali Muhammad Zakariya , Mohd Zuwairi Saiman , Henrik Toft Simonsen , Nur Kusaira Khairul Ikram

Phytochemistry Reviews, 2023, 23 (2), pp.283-320. ⟨10.1007/s11101-023-09897-6⟩

Article dans une revue hal-04694753v1

Current state, strategies, and perspectives in enhancing artemisinin production

Ali Muhammad Zakariya , Mohd Zuwairi Saiman , Henrik Toft Simonsen , Nur Kusaira Khairul Ikram

Phytochemistry Reviews, 2023, 23 (2), pp.283-320. ⟨10.1007/s11101-023-09897-6⟩

Article dans une revue hal-04820163v1

Dietary non-starch polysaccharides impair immunity to enteric nematode infection

Angela Valente , Karen Jensen , Laura Myhill , Ling Zhu , Caroline Mentzel et al.

BMC Biology, 2023, 21 (1), pp.138. ⟨10.1186/s12915-023-01640-z⟩

Article dans une revue hal-04503081v1

Lipidomes of Icelandic bryophytes and screening of high contents of polyunsaturated fatty acids by using lipidomics approach

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Nils Cronberg , Henrik Toft Simonsen

Phytochemistry, 2023, 206, pp.113560. ⟨10.1016/j.phytochem.2022.113560⟩

Article dans une revue hal-04503125v1
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Anti-Inflammatory Activity of Bryophytes Extracts in LPS-Stimulated RAW264.7 Murine Macrophages

Raíssa Volpatto Marques , Stefania Enza Sestito , Frédéric Bourgaud , Sissi Miguel , Frédéric Cailotto et al.

Molecules, 2022, 27 (6), pp.1940. ⟨10.3390/molecules27061940⟩

Article dans une revue hal-03652855v1

Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi

Miguel Peña-Espinoza , Yeambell Romero-Uzqueda , Angela Valente , Matthew de Roode , Henrik Toft Simonsen et al.

International journal for parasitology. Drugs and drug resistance, 2022, 20 (6), pp.43-53. ⟨10.1016/j.ijpddr.2022.08.002⟩

Article dans une revue hal-04503144v1

Lipidomic analysis of moss species Bryum pseudotriquetrum and Physcomitrium patens under cold stress

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Henrik Toft Simonsen

Plant-Environment Interactions, 2022, 3 (6), pp.254-263. ⟨10.1002/pei3.10095⟩

Article dans une revue hal-04503150v1

Identification of anti-parasitic agents in Cichorium intybus.

A Valente , M de Roode , M Peña-Espinoza , L Bornancin , Henrik Toft Simonsen et al.

Planta Medica, 2021, 87, pp.1266. ⟨10.1055/s-0041-1736835⟩

Article dans une revue hal-04503348v1
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Natural Products from Bryophytes: From Basic Biology to Biotechnological Applications

Armin Horn , Arnaud Pascal , Isidora Lončarević , Raíssa Volpatto Marques , Yi Lu et al.

Critical Reviews in Plant Sciences, 2021, 40 (3), pp.191-217. ⟨10.1080/07352689.2021.1911034⟩

Article dans une revue hal-04503375v1

Identification of compounds responsible for the anthelmintic effects of chicory (Cichorium intybus) by molecular networking and bio-guided fractionation

Angela Valente , Matthew de Roode , Madeleine Ernst , Miguel Peña-Espinoza , Louis Bornancin et al.

International journal for parasitology. Drugs and drug resistance, 2021, 15, pp.105-114. ⟨10.1016/j.ijpddr.2021.02.002⟩

Article dans une revue hal-04503390v1

Effects of extraction parameters on lipid profiling of mosses using UPLC-ESI-QTOF-MS and multivariate data analysis

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Henrik Toft Simonsen

Metabolomics, 2021, 17 (11), pp.96. ⟨10.1007/s11306-021-01847-7⟩

Article dans une revue hal-04503355v1

Collagenase and Tyrosinase Inhibitory Effect of Isolated Constituents from the Moss Polytrichum formosum

Raíssa Volpatto Marques , Agnès Guillaumin , Ahmed Abdelwahab , Aleksander Salwinski , Charlotte Gotfredsen et al.

Plants, 2021, 10 (7), pp.1271. ⟨10.3390/plants10071271⟩

Article dans une revue hal-04503369v1

Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds

Charlotte Smith Bonde , Louis Bornancin , Yi Lu , Henrik Toft Simonsen , María Martínez-Valladares et al.

Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.674520⟩

Article dans une revue hal-04503384v1

Cellulase and Macerozyme-PEG-mediated Transformation of Moss Protoplasts

Rituraj Batth , Ilenuta Simina Cuciurean , Satish Kumar Kodiripaka , Sarah Rothman , Caroline Greisen et al.

Bio-protocol , 2020, 10 (21), ⟨10.21769/BioProtoc.3782⟩

Article dans une revue hal-04503414v1

Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

Camilla Knudsen , Krutika Bavishi , Ketil Mathiasen Viborg , Damian Paul Drew , Henrik Toft Simonsen et al.

Phytochemistry, 2020, 170, pp.112214. ⟨10.1016/j.phytochem.2019.112214⟩

Article dans une revue hal-04504047v1

Biosynthesis and Industrial Production of Androsteroids

Rituraj Batth , Clément Nicolle , Ilenuta Simina Cuciurean , Henrik Toft Simonsen

Plants, 2020, 9 (9), pp.1144. ⟨10.3390/plants9091144⟩

Article dans une revue hal-04504039v1

Exploring evolutionary theories of plant defence investment using field populations of the deadly carrot

Karen Martinez-Swatson , Rasmus Kjøller , Federico Cozzi , Henrik Toft Simonsen , Nina Rønsted et al.

Annals of Botany, 2020, 125 (5), pp.737-750. ⟨10.1093/aob/mcz151⟩

Article dans une revue hal-04504043v1

Connecting moss lipid droplets to patchoulol biosynthesis

Anantha Peramuna , Hansol Bae , Carmen Quiñonero López , Arvid Fromberg , Bent Petersen et al.

PLoS ONE, 2020, 15 (12), pp.e0243620. ⟨10.1371/journal.pone.0243620⟩

Article dans une revue hal-04504029v1

Thapsigargins and induced chemical defence in Thapsia garganica

Karen Martinez-Swatson , Carmen Quiñonero-López , Madeleine Ernst , Nina Rønsted , Christopher James Barnes et al.

Chemoecology, 2020, 30 (5), pp.255-267. ⟨10.1007/s00049-020-00315-3⟩

Article dans une revue hal-04504033v1

Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity

Miguel Peña-Espinoza , Angela Valente , Louis Bornancin , Henrik Toft Simonsen , Stig Thamsborg et al.

Veterinary Parasitology, 2020, 280, pp.109088. ⟨10.1016/j.vetpar.2020.109088⟩

Article dans une revue hal-04504044v1

Valuable Fatty Acids in Bryophytes—Production, Biosynthesis, Analysis and Applications

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Henrik Toft Simonsen

Plants, 2019, 8 (11), pp.524. ⟨10.3390/plants8110524⟩

Article dans une revue hal-04504054v1

Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy

Trine Bundgaard Andersen , Silas Anselm Rasmussen , Søren Brøgger Christensen , Henrik Toft Simonsen

Phytochemistry, 2019, 157, pp.168-174. ⟨10.1016/j.phytochem.2018.10.027⟩

Article dans une revue hal-04504542v1

Valuable Fatty Acids in Bryophytes—Production, Biosynthesis, Analysis and Applications

Yi Lu , Finnur Freyr Eiriksson , Margrét Thorsteinsdóttir , Henrik Toft Simonsen

Plants, 2019, 8 (11), pp.524. ⟨10.3390/plants8110524⟩

Article dans une revue hal-04694762v1

Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens

Nur Kusaira Binti Khairul Ikram , Arman Beyraghdar , Anantha Peramuna , Alexander R. van der Krol , Harro Bouwmeester et al.

Molecules, 2019, 24 (21), pp.3822. ⟨10.3390/molecules24213822⟩

Article dans une revue hal-04504534v1

Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L.

Madeleine Ernst , Louis-Félix Nothias , Justin van der Hooft , Ricardo Silva , C. Haris Saslis-Lagoudakis et al.

Frontiers in Plant Science, 2019, 10, ⟨10.3389/fpls.2019.00846⟩

Article dans une revue hal-04504539v1

Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture

Ian David Woolsey , Angela Valente , Andrew Williams , Stig Thamsborg , Henrik Simonsen et al.

Scientific Reports, 2019, 9 (1), pp.20414. ⟨10.1038/s41598-019-56619-0⟩

Article dans une revue hal-04504048v1

Physcomitrella patens, a versatile synthetic biology chassis

Ralf Reski , Hansol Bae , Henrik Toft Simonsen

Plant Cell Reports, 2018, 37 (10), pp.1409-1417. ⟨10.1007/s00299-018-2293-6⟩

Article dans une revue hal-04694797v1

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

Miguel Peña-Espinoza , Angela Valente , Stig Thamsborg , Henrik Simonsen , Ulrik Boas et al.

Parasites & Vectors, 2018, 11 (1), pp.475. ⟨10.1186/s13071-018-3012-4⟩

Article dans une revue hal-04694793v1

In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries

Bjørn Dueholm , Damian Drew , Crystal Sweetman , Henrik Simonsen

Planta, 2018, 249 (1), pp.59-70. ⟨10.1007/s00425-018-2986-7⟩

Article dans une revue hal-04504526v1
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In vivo assembly of DNA-fragments in the moss, Physcomitrella patens

Brian Christopher King , Konstantinos Vavitsas , Nur Kusaira Binti Khairul Ikram , Josephine Schrøder , Lars B. Scharff et al.

Scientific Reports, 2016, 6 (1), ⟨10.1038/srep25030⟩

Article dans une revue hal-02885735v1
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Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily

Bjorn Dueholm , Celia Krieger , Damian Drew , Alexandre Olry , Tsunashi Kamo et al.

BMC Evolutionary Biology, 2015, 15, ⟨10.1186/s12862-015-0396-z⟩

Article dans une revue hal-01475932v1
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In vitro screening of Indian medicinal plants for antiplasmodial activity

Henrik Toft Simonsen , Jesper Brændegaard Nordskjold , Ulla Wagner Smitt , Ulf Nyman , Pushpangadan Palpu et al.

Journal of Ethnopharmacology, 2001, 74 (2), pp.195-204. ⟨10.1016/S0378-8741(00)00369-X⟩

Article dans une revue istex hal-04502853v1

Overexpression of Physcomitrium patens cell cycle regulators leads to larger gametophytes

Anantha Peramuna , Carmen Quiñonero López , Francisco Javier Astorga Rios , Hansol Bae , Jonatan Ulrik Fangel et al.

Bioactive Compounds in Bryophytes and Pteridophytes, 13 (1), Springer International Publishing, pp.4301, 2023, Reference Series in Phytochemistry, ⟨10.1038/s41598-023-31417-x⟩

Chapitre d'ouvrage hal-04503118v1

Extracts from the Liverwort Bazzania trilobata with Potential Dermo-cosmetic Properties

Raíssa Volpatto Marques , Aleksander Salwinski , Kasper Enemark-Rasmussen , Charlotte Gotfredsen , Yi Lu et al.

Bioactive Compounds in Bryophytes and Pteridophytes, Springer International Publishing, pp.147-164, 2023, Reference Series in Phytochemistry, ⟨10.1007/978-3-031-23243-5_9⟩

Chapitre d'ouvrage hal-04246885v1

From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development

Søren Brøgger Christensen , Henrik Toft Simonsen , Nikolai Engedal , Poul Nissen , Jesper Vuust Møller et al.

Progress in the Chemistry of Organic Natural Products 115, 115, Springer International Publishing, pp.59-114, 2021, Progress in the Chemistry of Organic Natural Products, ⟨10.1007/978-3-030-64853-4_2⟩

Chapitre d'ouvrage hal-04503397v1

Developments and Perspectives in Bryophyte Biotechnology in Sub-Saharan Africa

Kenneth Yongabi Anchang , Henrik Toft Simonsen

Biotechnology and Bioengineering, IntechOpen, 2019, ⟨10.5772/intechopen.81692⟩

Chapitre d'ouvrage hal-04504523v1