Isabelle Fudal

51
Documents
Affiliation actuelle
  • BIOlogie et GEstion des Risques en agriculture (BIOGER)
Identifiants chercheurs
Contact

Présentation

Address:
Unité Bioger (UR 1290)
Team Effecteurs et pathogenèse chez Leptosphaeria maculans
Batiment F. Campus AgroParisTech. 22 place de l'agronomie.
91120 Palaiseau.

Contact :
Tél. : +33 (0)6 80 78 46 33 Mail : Isabelle.Fudal@inrae.fr

Research

I am a research scientist hired at INRA in the BIOGER unit in 2006, with a background in plant pathology, molecular biology and functional genomics. My main focus was, and still is, on deciphering fungal-plant interactions. Most of my research experience was devoted to understand fungal pathogenicity and signals produced by the fungus, which induce recognition of “non-self” and disease resistance (avirulence genes or effectors). Since I was hired as a permanent scientist at INRA, I am developing functional genomics approaches on plant-fungi interactions with a particular interest to fungal effectors on the model of interaction Leptosphaeria maculans / Brassica napus. The objective of my research project is to study the possible roles of effectors on pathogenicity towards B. napus (identification, expression, regulation, evolution and functional analysis). To achieve this goal, I develop a pluri-disciplinary project combining bioinformatics, transcriptomics, functional genomics, pathogenicity studies and evolutionary genomics. Recently, I focused part of my researches on the determinism of concerted regulation of effector genes during infection and pointed out on the importance of chromatin status in this regulation. I am co-leading the INRA SPE network REacTION (network on the epigenetic mechanisms that shape plant - Bioaggressors and Symbiotic Organisms interactions)

Curriculum vitae

Since 2020

INRAE Senior Researcher, UMR1290 BIOGER, Grignon

2014

HDR, Université Paris-Sud, Orsay

2006-2019

INRA Researcher Scientist, UMR1290 Bioger, INRA, Grignon

2004-2006

Postdoc, Unité PMDV, INRA, Versailles

2000-2004

PhD, Université Paris-Sud, Orsay

1999-2000

Master Biologie, Diversité et Adaptation des Plantes Cultivées : option Phytopathologie (Paris)

1997- 2000

Engineer degree, Institut National Agronomique Paris-Grignon (INA P-G, Paris)

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Publications

Molecular Investigation of Rlm3 From Rapeseed as a Potential Broad‐Spectrum Resistance Gene Against Fungal Pathogens Producing Structurally Conserved Effectors

Nacera Talbi , Simine Pakzad , Françoise Blaise , Bénédicte Ollivier , Thierry Rouxel et al.
Plant Pathology, 2025, ⟨10.1111/ppa.70063⟩
Article dans une revue hal-05274184 v1

Regulation of effector gene expression as concerted waves in Leptosphaeria maculans : a two‐player game

Colin Clairet , Elise Gay , Antoine Porquier , Françoise Blaise , Claire‐line Marais et al.
New Phytologist, 2024, 242 (1), pp.247-261. ⟨10.1111/nph.19581⟩
Article dans une revue hal-04480387 v1
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Facilitation of symplastic effector protein mobility by paired effectors is conserved in different classes of fungal pathogens

Nacera Talbi , Mila Blekemolen , Slavica Janevska , Daniel Zendler , Herman van Tilbeurgh et al.
Molecular Plant-Microbe Interactions, 2024, 37 (3), pp.304-314. ⟨10.1094/MPMI-07-23-0103-FI⟩
Article dans une revue hal-04232770 v1

The neighbouring genes AvrLm10A and AvrLm10B are part of a large multigene family of cooperating effector genes conserved in Dothideomycetes and Sordariomycetes

Nacera Talbi , Like Fokkens , Corinne Audran , Yohann Petit-Houdenot , Cécile Pouzet et al.
Molecular Plant Pathology, 2023, 24, pp.914-931. ⟨10.1111/MPP.13338⟩
Article dans une revue hal-04090329 v1
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Improving sustainable crop protection using population genetics concepts

Méline Saubin , Clémentine Louet , Lydia Bousset , Frédéric Fabre , Pascal Frey et al.
Molecular Ecology, 2023, 32 (10), pp.2461-2471. ⟨10.1111/mec.16634⟩
Article dans une revue (article de synthèse) hal-03394837 v2
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Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures

Colin Clairet , Nicolas Lapalu , Adeline Simon , Jessica Soyer , Muriel Viaud et al.
Peer Community Journal, 2023, 3, pp.e13. ⟨10.24072/pcjournal.227⟩
Article dans une revue hal-04088414 v1
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A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins

Noureddine Lazar , Carl Mesarich , Yohann Petit-Houdenot , Nacera Talbi , Ines Li de La Sierra-Gallay et al.
PLoS Pathogens, 2022, 18 (7), pp.e1010664. ⟨10.1371/journal.ppat.1010664⟩
Article dans une revue hal-03324327 v1
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A gene‐for‐gene interaction involving a ‘late’ effector contributes to quantitative resistance to the stem canker disease in Brassica napus

Audren Jiquel , Julie Gervais , Aude Geistodt‐kiener , Régine Delourme , Elise Gay et al.
New Phytologist, 2021, 231 (4), pp.1510-1524. ⟨10.1111/nph.17292⟩
Article dans une revue hal-03155959 v1
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A new avirulence gene of Leptosphaeria maculans , AvrLm14 , identifies a resistance source in American broccoli ( Brassica oleracea ) genotypes

Alexandre A. Degrave , Marine Wagner , Pierre George , Laurent Coudard , Xavier Pinochet et al.
Molecular Plant Pathology, 2021, 22 (12), pp.1599-1612. ⟨10.1111/mpp.13131⟩
Article dans une revue hal-03344127 v1
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Genome-wide mapping of histone modifications during axenic growth in two species of Leptosphaeria maculans showing contrasting genomic organization

Jessica Soyer , Colin Clairet , Elise Gay , Nicolas Lapalu , Thierry Rouxel et al.
Chromosome Research, 2021, 29 (2), pp.219-236. ⟨10.1007/s10577-021-09658-1⟩
Article dans une revue hal-03266749 v1
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Large-scale transcriptomics to dissect 2 years of the life of a fungal phytopathogen interacting with its host plant

Elise J Gay , Jessica L Soyer , Nicolas Lapalu , Juliette Linglin , Isabelle Fudal et al.
BMC Biology, 2021, 19 (1), pp.e041118. ⟨10.1186/s12915-021-00989-3⟩
Article dans une revue hal-03190704 v1

Apoplastic effector proteins of plant-associated fungi and oomycetes

Mercedes Rocafort , Isabelle Fudal-Grolier Fudal , Carl Mesarich
Current Opinion in Plant Biology, 2020, 56, pp.9-19. ⟨10.1016/j.pbi.2020.02.004⟩
Article dans une revue hal-02894839 v1

A two genes – for – one gene interaction between Leptosphaeria maculans and Brassica napus

Yohann Petit-Houdenot , Alexandre A. Degrave , Michel Meyer , Françoise Blaise , Bénédicte Ollivier et al.
New Phytologist, 2019, 223 (1), pp.397-411. ⟨10.1111/nph.15762⟩
Article dans une revue hal-02278749 v1

Effector Biology in Fungal Pathogens of Nonmodel Crop Plants

Isabelle Fudal , Marie-Helene Balesdent , Thierry Rouxel
Trends in Plant Science, 2018, 23 (9), pp.753 - +. ⟨10.1016/j.tplants.2018.07.002⟩
Article dans une revue hal-02626782 v1

The genome biology of effector gene evolution in filamentous plant pathogens

Andrea Sanchez-Vallet , Simone Fouche , Isabelle Fudal , Fanny E. Hartmann , Jessica L Soyer et al.
Annual Review of Phytopathology, 2018, 56, ⟨10.1146/annurev-phyto-080516-035303⟩
Article dans une revue (article de synthèse) hal-02628719 v1
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Different waves of effector genes with contrasted genomic location are expressed by Leptosphaeria maculans during cotyledon and stem colonization of oilseed rape

Julie Gervais , Clémence Plissonneau , Juliette Linglin , Michel Meyer , Karine Labadie et al.
Molecular Plant Pathology, 2017, 18 (8), pp.1113 - 1126. ⟨10.1111/mpp.12464⟩
Article dans une revue hal-01608614 v1
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Complex Interactions between Fungal Avirulence Genes and Their Corresponding Plant Resistance Genes and Consequences for Disease Resistance Management

Yohann Petit , Isabelle Fudal
Frontiers in Plant Science, 2017, 8, ⟨10.3389/fpls.2017.01072⟩
Article dans une revue hal-01602583 v1
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The N-end rule pathway regulates pathogen responses in plants

Rémi de Marchi , Maud Sorel , Brian Mooney , Isabelle Fudal-Grolier Fudal , Kevin Goslin et al.
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep26020⟩
Article dans une revue hal-02104524 v1
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A game of hide and seek between avirulence genes AvrLm4‐7 and AvrLm3 in Leptosphaeria maculans

Clémence Plissonneau , Guillaume Daverdin , Bénédicte Ollivier , Françoise Blaise , Alexandre A. Degrave et al.
New Phytologist, 2016, 209 (4), pp.1613-1624. ⟨10.1111/nph.13736⟩
Article dans une revue hal-02516669 v1

The APSES transcription factor LmStuA is required for sporulation, pathogenic development and effector gene expression in Leptosphaeria maculans

Jessica Louise Soyer , Audrey Hamiot , Benedicte Ollivier , Marie-Helene Balesdent , Thierry Rouxel et al.
Molecular Plant Pathology, 2015, 16 (9), pp.1000-1005. ⟨10.1111/mpp.12249⟩
Article dans une revue hal-01536499 v1

Chromatin-based control of effector gene expression in plant-associated fungi

Jessica L. Soyer , Thierry T. Rouxel , Isabelle Fudal-Grolier Fudal
Current Opinion in Plant Biology, 2015, 26, pp.51-56. ⟨10.1016/j.pbi.2015.05.025⟩
Article dans une revue istex hal-02638628 v1

Crystal structure of the effector AvrLm4-7 of Leptosphaeria maculans reveals insights into its translocation into plant cells and recognition by resistance proteins.

Karine Blondeau , Françoise Blaise , Marc Graille , Shiv D Kale , Juliette Linglin et al.
The Plant Journal, 2015, 83 (4), pp.610-24. ⟨10.1111/tpj.12913⟩
Article dans une revue hal-01446655 v1

Rapid identification of the Leptosphaeria maculans avirulence gene AvrLm2 using an intraspecific comparative genomics approach

Kaveh Ghanbarnia , Isabelle Fudal , Nicholas J. Larkan , Matthew G. Links , Marie-Helene Balesdent et al.
Molecular Plant Pathology, 2015, 16 (7), pp.699 - 709. ⟨10.1111/mpp.12228⟩
Article dans une revue hal-01536462 v1

Quantitative resistance affects the speed of frequency increase but not the diversity of the virulence alleles overcoming a major resistance gene to [i]Leptosphaeria maculans[/i] in oilseed rape

Régine Delourme , Lydia Bousset , Magali Ermel , Philippe Duffe , Anne-Laure Besnard et al.
Infection, Genetics and Evolution, 2014, 27, pp.490-499. ⟨10.1016/j.meegid.2013.12.019⟩
Article dans une revue hal-01208690 v1
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Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus [i]Leptosphaeria maculans[/i]

Jessica Soyer , Mennat El Ghalid , Nicolas Glaser , Bénédicte Ollivier , Juliette Linglin et al.
PLoS Genetics, 2014, 10 (3), 19 p. ⟨10.1371/journal.pgen.1004227⟩
Article dans une revue hal-01019254 v1
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Transposable element-assisted evolution and adaptation to host plant within the Leptosphaeria maculans-Leptosphaeria biglobosa species complex of fungal pathogens

Jonathan J. Grandaubert , Rohan G.T. Lowe , Jessica L. Soyer , C.L. Schoch , Angela P van de Wouw et al.
BMC Genomics, 2014, 15 (891), pp.OA. ⟨10.1186/1471-2164-15-891⟩
Article dans une revue hal-02631920 v1
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Microbe-Independent Entry of Oomycete RxLR Effectors and Fungal RxLR-Like Effectors Into Plant and Animal Cells Is Specific and Reproducible

Brett M. B. M. Tyler , Shiv D. S. D. Kale , Qunqing Q. Wang , Kai K. Tao , Helen R. H. R. Clark et al.
Molecular Plant-Microbe Interactions, 2013, 26 (6), pp.611 - 616. ⟨10.1094/mpmi-02-13-0051-ia⟩
Article dans une revue hal-01001070 v1
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The dispensable chromosome of Leptosphaeria maculans shelters an effector gene conferring avirulence towards Brassica rapa.

Marie-Helene Balesdent , Isabelle Fudal-Grolier Fudal , Bénédicte B. Ollivier , Pascal P. Bally , Jonathan J. Grandaubert et al.
New Phytologist, 2013, 198 (3), pp.887-898. ⟨10.1111/nph.12178⟩
Article dans une revue hal-01004245 v1
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Genome Structure and Reproductive Behaviour Influence the Evolutionary Potential of a Fungal Phytopathogen

Guillaume Daverdin , Thierry Rouxel , Lilian Gout , Jean-Noël Aubertot , Isabelle Fudal et al.
PLoS Pathogens, 2012, 8 (11), 15 p. ⟨10.1371/journal.ppat.1003020⟩
Article dans une revue hal-01019027 v1
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Incidence of Genome Structure, DNA Asymmetry, and Cell Physiology on T-DNA Integration in Chromosomes of the Phytopathogenic Fungus Leptosphaeria maculans

Ahmed Salim A. S. Bourras , Michel M. Meyer , Jonathan J. Grandaubert , Nicolas Lapalu , Isabelle Fudal-Grolier Fudal et al.
G3, 2012, 2 (8), pp.891-904. ⟨10.1534/g3.112.002048⟩
Article dans une revue hal-01000638 v1
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Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

Thierry Rouxel , J. Grandaubert , Jk. Hane , Claire Hoede , Angela P. van de Wouw et al.
Nature Communications, 2011, 2, pp.202. ⟨10.1038/ncomms1189⟩
Article dans une revue hal-00841751 v1

External lipid P13P mediates entry of eukaryotic pathogen effectors into plant and animal host cells

Shiv D. Kale , Biao Gu , Daniel G.S. Capelluto , Daolong Dou , Emily Feldman et al.
Cell, 2010, 142 (2), pp.284-295. ⟨10.1016/j.cell.2010.06.008⟩
Article dans une revue hal-02667928 v1

Repeat-induced point mutation (RIP) as an alternative mechanism of evolution toward virulence in Leptosphaeria maculans

Isabelle Fudal-Grolier Fudal , Simon Ross , Hortense H. Brun , Anne-Laure Besnard , Magali M. Ermel et al.
Molecular Plant-Microbe Interactions, 2009, 22 (8), pp.932-941. ⟨10.1094/MPMI-22-8-0932⟩
Article dans une revue hal-02667764 v1

Leptosphaeria maculans avirulence gene AvrLm4-7 confers a dual recognition specificity by the Rlm4 and Rlm7 resistance genes of oilseed rape and circumvents Rlm4-mediated recognition through a single amino acid change

Francis Parlange , Guillaume G. Daverdin , Marie-Line Kuhn , Isabelle Fudal-Grolier Fudal , Marie-Helene Balesdent et al.
Molecular Microbiology, 2009, 71 (4), pp.851-863. ⟨10.1111/j.1365-2958.2008.06547.x⟩
Article dans une revue hal-02663864 v1

Magnaporthe grisea avirulence gene ACE1 belons to an infection-specific gene cluster involved in secondary metabolism

Jérôme Collemare , Mikaël Pianfetti , Anne-Élodie Houlle , Damien Morin , Laurent Camborde et al.
New Phytologist, 2008, Pathogenic plant–fungus interactions, 179 (1), pp.196-208. ⟨10.1111/j.1469-8137.2008.02459.x⟩
Article dans une revue hal-02669102 v1

Heterochromatin-like regions as ecological niches for avirulence genes in the Leptosphaeria maculans genome : map-based cloning of AvrLm6

Isabelle Fudal-Grolier Fudal , S Ross , Lilian L. Gout , Francoise F. Blaise , Marie-Line Kuhn et al.
Molecular Plant-Microbe Interactions, 2007, 20 (4), pp.459-470. ⟨10.1094/MPMI-20-4-0459⟩
Article dans une revue hal-02656853 v1

Expression of Magnaporthe grisea Avirulence Gene ACE1 Is Connected to the Initiation of Appressorium-Mediated Penetration

Isabelle Fudal , Jérôme Collemare , Heidi U. Böhnert , Delphine Melayah , Marc-Henri Lebrun
Eukaryotic Cell, 2007, 6 (3), pp.546-554. ⟨10.1128/EC.00330-05⟩
Article dans une revue halsde-00180977 v1

Lost in the middle of nowhere: the AvrLm1 avirulence gene of the dothideomycete Leptosphaeria maculans

Lilian L. Gout , Isabelle Fudal-Grolier Fudal , Marie-Line Kuhn , Francoise F. Blaise , Maria Eckert et al.
Molecular Microbiology, 2006, 60 (1), pp.67-80. ⟨10.1111/j.1365-2958.2006.05076.x⟩
Article dans une revue hal-02662679 v1

Origins of host-specific populations of the blast pathogen Magnaporthe oryzae in crop domestication with subsequent expansion of pandemic clones on rice and weeds of rice

Brett C Couch , Isabelle Fudal , Marc-Henri M.-H. Lebrun , Didier Tharreau , Barbara Valent et al.
Genetics, 2005, 170 (2), pp.613-630. ⟨10.1534/genetics.105.041780⟩
Article dans une revue hal-02681928 v1
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Mécanismes épigénétiques des interactions hôte-agent pathogène

Christoph Grunau , Isabelle Fudal , Nadia Ponts
Hélène Jammes; Pierre Boudry; Stéphane Maury. Epigénétique. Mécanismes moléculaires, biologie du développement et réponses à l'environnement, Editions Quae, pp.133-144, 2024, 978-2-7592-3769-2
Chapitre d'ouvrage hal-04613807 v1
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Epigenetic regulation of fungal genes involved in plant colonization

Jessica L. Soyer , Isabelle Fudal
The Mycota, Plant Relationships / Fungal – plant interactions., 5, springer, pp.255-281, 2023, ⟨10.1007/978-3-031-16503-0⟩
Chapitre d'ouvrage hal-04432844 v1

Techniques d’identification de régions génomiques accessibles à des régulateurs : FAIRE et ATAC

Isabelle Fudal , Nadia Ponts
Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3
Chapitre d'ouvrage hal-04567382 v1

Méthode de détermination du positionnement des nucléosomes : MAINE

Isabelle Fudal , Nadia Ponts
Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3
Chapitre d'ouvrage hal-04567389 v1

Structure de la chromatine

Isabelle Fudal , Nadia Ponts
Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3
Chapitre d'ouvrage hal-04567393 v1

Immunoprécipitation de la chromatine

Isabelle Fudal , Nadia Ponts
Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3
Chapitre d'ouvrage hal-04567380 v1

La méthylation de l’ADN

Isabelle Fudal , Nadia Ponts
Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3
Chapitre d'ouvrage hal-04567334 v1