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ISABELLE VAN SEUNINGEN

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MUC1 Drives the Progression and Chemoresistance of Clear Cell Renal Carcinomas

Emma Bourdon , Thomas Swierczewski , Marine Goujon , Nihad Boukrout , Sandy Fellah
Cancers, 2024, 16 (2), pp.391. ⟨10.3390/cancers16020391⟩
Journal articles inserm-04479812v1
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Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?

Arnaud Jannin , Anne-Frédérique Dessein , Christine Do Cao , Marie-Christine Vantyghem , Benjamin Chevalier
Frontiers in Endocrinology, 2023, 14, ⟨10.3389/fendo.2023.1248575⟩
Journal articles hal-04273585v1
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A Double-Negative Feedback Interaction between miR-21 and PPAR-α in Clear Renal Cell Carcinoma

Marine Goujon , Justine Woszczyk , Kelly Gaudelot , Thomas Swierczewski , Sandy Fellah
Cancers, 2022, 14 (3), pp.795. ⟨10.3390/cancers14030795⟩
Journal articles inserm-03729282v1
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TRPM7 Modulates Human Pancreatic Stellate Cell Activation.

Julie Auwercx , Philippe Kischel , Thibaut Lefebvre , Nicolas Jonckheere , Alison Vanlaeys
Cells, 2022, 11 (14), pp.2255. ⟨10.3390/cells11142255⟩
Journal articles hal-03740502v1

TRPM7 Modulates Human Pancreatic Stellate Cell Activation

Julie Auwercx , Philippe Kischel , Thibaut Lefebvre , Nicolas Jonckheere , Alison Vanlaeys
Cells, 2022, 11 (14), pp.2255. ⟨10.3390/cells11142255⟩
Journal articles hal-04542482v1

Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells

Marjolaine Bauzone , Mouloud Souidi , Anne-Frédérique Dessein , Maxence Wisztorski , Audrey Vincent
Molecular Cancer Research, 2021, 19 (4), pp.612-622. ⟨10.1158/1541-7786.MCR-20-0462⟩
Journal articles hal-04284692v1

Mg2+ Transporters in Digestive Cancers

Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain
Nutrients, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩
Journal articles hal-04542501v1
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The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

Nicolas Stoup , Maxime Liberelle , Céline Schulz , Sumeyye Cavdarli , Romain Vasseur
Cancers, 2021, 13 (22), pp.5746. ⟨10.3390/cancers13225746⟩
Journal articles hal-03641795v1
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Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma

Nihad Boukrout , Mouloud Souidi , Fatima Lahdaoui , Belinda Duchêne , Bernadette Neve
Cancers, 2021, 13 (24), pp.6197. ⟨10.3390/cancers13246197⟩
Journal articles hal-03777017v1

MUC1 Mitigates Renal Injury and Inflammation in Endotoxin-Induced Acute Kidney Injury by Inhibiting the TLR4-MD2 Axis and Reducing Pro-inflammatory Macrophages Infiltration

Jean-Baptiste Gibier , Thomas Swierczewski , Marie Csanyi , Brigitte Hemon , Francois Glowacki
Shock, 2021, 56 (4), pp.629-638. ⟨10.1097/SHK.0000000000001742⟩
Journal articles hal-03379151v1
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Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sda synthase) gene: B4GALNT2 is transcriptionally regulated by ETS1

Cindy Wavelet-Vermuse , Sophie Groux-Degroote , Dorothée Vicogne , Virginie Cogez , Giulia Venturi
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2021, 1864 (11-12), pp.194747. ⟨10.1016/j.bbagrm.2021.194747⟩
Journal articles hal-03345208v1
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Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish

Ludivine Raby , Pamela Völkel , Shaghayegh Hasanpour , Julien Cicero , Robert-Alain Toillon
Cells, 2021, 10 (11), pp.3142. ⟨10.3390/cells10113142⟩
Journal articles hal-04488645v1
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Fabricating Silicon Resonators for Analysing Biological Samples

Momoko Kumemura , Deniz Pekin , Vivek Anand Menon , Isabelle van Seuningen , Dominique Collard
Micromachines, 2021, 12 (12), pp.1546. ⟨10.3390/mi12121546⟩
Journal articles hal-03501246v1
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A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms

Elsa Hadj Bachir , Charles Poiraud , Sonia Paget , Nicolas Stoup , Soumaya El Moghrabi
Biology of the Cell, 2021, 114 (1), pp.32-55. ⟨10.1111/boc.202100003⟩
Journal articles hal-03369738v1
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Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers

Nicolas Jonckheere , Audrey Vincent , Bernadette Neve , Isabelle van Seuningen
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021, 1876 (1), pp.188538. ⟨10.1016/j.bbcan.2021.188538⟩
Journal articles hal-03294583v1
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Mg2+ Transporters in Digestive Cancers

Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain
Nutrients, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩
Journal articles hal-03195960v1

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti , Satoru Yonekura , Connie Duong , Marion Picard , Gladys Ferrere
Nature Medicine, 2020, 26 (6), pp.919-931. ⟨10.1038/s41591-020-0882-8⟩
Journal articles hal-04210282v1

EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway?

Maxime Liberelle , Nicolas Jonckheere , Patricia Melnyk , Isabelle van Seuningen , Nicolas Lebègue
Journal of Medicinal Chemistry, 2020, 63 (10), pp.5074-5088. ⟨10.1021/acs.jmedchem.9b02001⟩
Journal articles hal-02955348v1
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Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface

Lucie Coppin , Arnaud Jannin , Emilie Ait Yahya , Caroline Thuillier , Céline Villenet
Cell Death and Disease, 2020, 11, pp.360. ⟨10.1038/s41419-020-2556-3⟩
Journal articles hal-03060582v1

Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival

Nicolas Jonckheere , Julie Auwercx , Elsa Hadj Bachir , Lucie Coppin , Nihad Boukrout
Cancers, 2020, 12 (11), pp.3309. ⟨10.3390/cancers12113309⟩
Journal articles hal-04542511v1
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Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival

Nicolas Jonckheere , Julie Auwercx , Elsa Hadj Bachir , Lucie Coppin , Nihad Boukrout
Cancers, 2020, 12 (11), pp.3309. ⟨10.3390/cancers12113309⟩
Journal articles hal-03003452v2

Long non-coding RNAs: the tentacles of chromatin remodeler complexes

Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen
Cellular and Molecular Life Sciences, 2020, 78 (4), pp.1139-1161. ⟨10.1007/s00018-020-03646-0⟩
Journal articles hal-03195963v1

Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface

Lucie Coppin , Arnaud Jannin , Emilie Ait Yahya , Caroline Thuillier , Céline Villenet
Cell Death and Disease, 2020, 11 (5), pp.360. ⟨10.1038/s41419-020-2556-3⟩
Journal articles hal-04535804v1
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti , Satoru Yonekura , Connie P. M. Duong , Marion Picard , Gladys Ferrere
Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩
Journal articles hal-03313676v1
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MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis

Maxime Liberelle , Romain Magnez , Xavier Thuru , Yamina Bencheikh , Séverine Ravez
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-53099-0⟩
Journal articles hal-02407901v1

Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype

Mehdi El Amrani , François Corfiotti , Matthieu Corvaisier , Romain Vasseur , Maxence Fulbert
Molecular Carcinogenesis, 2019, 58 (11), pp.1985-1997. ⟨10.1002/mc.23090⟩
Journal articles inserm-02352000v1
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Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies

Audrey Vincent , Aïcha Ouelkdite-Oumouchal , Mouloud Souidi , Julie Leclerc , Bernadette Neve
World Journal of Stem Cells, 2019, 11 (11), pp.920-936. ⟨10.4252/wjsc.v11.i11.920⟩
Journal articles inserm-02351996v1
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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required

Nicolas Jonckheere , Isabelle van Seuningen
Annals of translational medicine, 2019, 7 (S1), pp.S43-S43. ⟨10.21037/atm.2019.03.01⟩
Journal articles inserm-02341315v1

Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia.

Mélanie Lambert , Meryem Alioui , Samy Jambon , Sabine Depauw , Isabelle van Seuningen
Cancers, 2019, 11 (6), pp.837. ⟨10.3390/cancers11060837⟩
Journal articles hal-02358430v1
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TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

Vincent Drubay , Nicolas Skrypek , Lucie Cordiez , Romain Vasseur , Céline Schulz
Cancers, 2018, 10 (8), pii: E254. ⟨10.3390/cancers10080254⟩
Journal articles inserm-02341320v1
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Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer

Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen
Cancers, 2018, 10 (11), pp.440. ⟨10.3390/cancers10110440⟩
Journal articles inserm-02341333v1
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Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.

Nicolas Jonckheere , Isabelle van Seuningen
Journal of Translational Medicine, 2018, 16 (1), pp.259. ⟨10.1186/s12967-018-1632-2⟩
Journal articles hal-02341297v1
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The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting

Nicolas Jonckheere , Romain Vasseur , Isabelle Van Seuningen
Critical Reviews in Oncology/Hematology, 2017, 111, pp.7-19. ⟨10.1016/j.critrevonc.2017.01.002⟩
Journal articles inserm-02341607v1

Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway

Fatima Lahdaoui , Mathieu Messager , Audrey Vincent , Flora Hec , Anne Gandon
Biochemical Journal, 2017, 474 (22), pp.3733-3746. ⟨10.1042/BCJ20170348⟩
Journal articles inserm-02341337v1
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Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers

Michaël Duruisseaux , Martine Antoine , Nathalie Rabbe , Anita Rodenas , Anne Mc Leer-Florin
Lung Cancer, 2017, 109, pp.92-100. ⟨10.1016/j.lungcan.2017.05.007⟩
Journal articles hal-01535623v1

Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma

Kelly Gaudelot , Jean-Baptiste Gibier , Nicolas Pottier , Brigitte Hémon , Isabelle van Seuningen
Tumor Biology, 2017, 39 (7), pp.101042831770737. ⟨10.1177/1010428317707372⟩
Journal articles hal-03313744v1
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Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells

Lucie Coppin , Audrey Vincent , Frédéric Frénois , Belinda Duchêne , Fatima Lahdaoui
Scientific Reports, 2017, 7, pp.43927. ⟨10.1038/srep43927⟩
Journal articles hal-01534451v1

Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase

Jean-Baptiste Gibier , Brigitte Hemon , Melanie Fanchon , Kelly Gaudelot , Nicolas Pottier
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, 1863 (6), pp.1336 - 1349. ⟨10.1016/j.bbadis.2017.03.023⟩
Journal articles inserm-01833348v1

Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Rémi Porte , Laurye van Maele , Natalia Muñoz-Wolf , Benoit Foligné , Laure Dumoutier
Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩
Journal articles inserm-01529315v1
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Hemidesmosome integrity protects the colon against colitis and colorectal cancer

Adèle de Arcangelis , Hussein Hamade , Fabien Alpy , Sylvain Normand , Emilie Bruyère
Gut, 2016, 66 (10), pp.gutjnl--2015--310847. ⟨10.1136/gutjnl-2015-310847⟩
Journal articles hal-01538539v1
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The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential

Florence Renaud , Christophe Mariette , Audrey Vincent , Agnès Wacrenier , Vincent Maunoury
International Journal of Cancer, 2016, 138, pp.1472-1481. ⟨10.1002/ijc.29891⟩
Journal articles hal-02905823v1

Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse

Matthieu Corvaisier , Marjolaine Bauzone , François Corfiotti , Florence Renaud , Mehdi El Amrani
Oncotarget, 2016, 7 (35), pp.56699-56712. ⟨10.18632/oncotarget.11057⟩
Journal articles hal-03313749v1
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Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells

Solange Tréhoux , Fatima Lahdaoui , Yannick Delpu , Florence Renaud , Emmanuelle Leteurtre
Biochimica et Biophysica Acta - Molecular Cell Research, 2015, ⟨10.1016/j.bbamcr.2015.05.033⟩
Journal articles hal-02905657v1
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Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival

Thibault Desurmont , Nicolas Skrypek , Alain Duhamel , Nicolas Jonckheere , Guillaume Millet
Cancer Science, 2015, 106 (3), pp.262-269. ⟨10.1111/cas.12603⟩
Journal articles hal-02954490v1

Suitability of Surgically Induced Chronic Reflux in Rats for Studying Esophageal Carcinogenesis

Caroline Gronnier , Guillaume Piessen , Emmanuelle Leteurtre , Isabelle van Seuningen , Christophe Mariette
Annals of Surgery, 2015, 261 (5), pp.e140-e141. ⟨10.1097/SLA.0000000000000474⟩
Journal articles hal-03313754v1
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The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways

Romain Vasseur , Nicolas Skrypek , Belinda Duchêne , Florence Renaud , Daniel Martínez-Maqueda
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2015, 1849 (12), pp.1375-1384. ⟨10.1016/j.bbagrm.2015.10.014⟩
Journal articles hal-02906327v1
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Cryosectioning the intestinal crypt-villus axis: An ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells

Audrey Vincent , Catherine Kazmierczak , Belinda Duchêne , Nicolas Jonckheere , Emmanuelle Leteurtre
Stem Cell Research, 2015, 14, ⟨10.1016/j.scr.2014.12.002⟩
Journal articles hal-02905864v1
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Targeting MUC4 in pancreatic cancer: miRNAs

Nicolas Jonckheere , Fatima Lahdaoui , Isabelle van Seuningen
Oncoscience, 2015, 2 (10), pp.799-800. ⟨10.18632/oncoscience.249⟩
Journal articles hal-02905858v1
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The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

Nicolas Skrypek , Romain Vasseur , Audrey Vincent , Bélinda Duchêne , Isabelle van Seuningen
Oncotarget, 2015, 6 (13), pp.10853-1067. ⟨10.18632/oncotarget.3414⟩
Journal articles inserm-02341515v1
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MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer

Florence Renaud , Audrey Vincent , Christophe Mariette , Michel Crépin , Laurence Stechly
International Journal of Cancer, 2015, 136, pp.2811 - 2821. ⟨10.1002/ijc.29342⟩
Journal articles hal-02905819v1

MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway

Audrey Bouillez , Viviane Gnemmi , Kelly Gaudelot , Brigitte Hémon , Bélinda Ringot
Oncotarget, 2014, 5 (3), pp.754-763. ⟨10.18632/oncotarget.1768⟩
Journal articles hal-03313775v1
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The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells

Caroline Gronnier , Emilie Bruyère , Fatima Lahdaoui , Nicolas Jonckheere , Michael Perrais
Biochimica et Biophysica Acta - Molecular Cell Research, 2014, ⟨10.1016/j.bbamcr.2014.06.021⟩
Journal articles hal-02905652v1

MUC1 Expression in Papillary Thyroid Carcinoma Is Associated with BRAF Mutation and Lymph Node Metastasis; the Latter is the Most Important Risk Factor of Relapse

Florence Renaud , Viviane Gnemmi , Patrick Devos , Sébastien Aubert , Michel Crépin
Thyroid, 2014, 24 (9), pp.1375-1384. ⟨10.1089/thy.2013.0594⟩
Journal articles hal-03313761v1

MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter

Viviane Gnemmi , Audrey Bouillez , Kelly Gaudelot , Brigitte Hémon , Bélinda Ringot
Cancer Letters, 2014, 346 (2), pp.225-236. ⟨10.1016/j.canlet.2013.12.029⟩
Journal articles hal-03313770v1
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Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth

Audrey Vincent , Seung-Mo Hong , Chaoxin Hu , Noriyuki Omura , Angela Young
Oncotarget, 2014, 5 (9), pp.2575-2587. ⟨10.18632/oncotarget.1842⟩
Journal articles hal-02905879v1

Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

Xavier Tréton , Eric Pedruzzi , Cécile Guichard , Yannick Ladeiro , Shirin Sedghi
PLoS ONE, 2014, 9 (7), pp.e101669. ⟨10.1371/journal.pone.0101669⟩
Journal articles hal-03313755v1
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Mucins and tumor resistance to chemotherapeutic drugs

Nicolas Jonckheere , Nicolas Skrypek , Isabelle Van Seuningen
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014, 1846 (1), pp.142-151. ⟨10.1016/j.bbcan.2014.04.008⟩
Journal articles inserm-02341531v1
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Of autophagy and in vivo pancreatic carcinogenesis: The p53 status matters!

Nicolas Jonckheere , Audrey Vincent , Isabelle Van Seuningen
Clinics and Research in Hepatology and Gastroenterology, 2014, 38 (4), pp.423-425. ⟨10.1016/j.clinre.2014.04.009⟩
Journal articles inserm-02341594v1
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MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway

Audrey Bouillez , Viviane Gnemmi , Kelly Gaudelot , Brigitte Hemon , Bélinda Ringot
Oncotarget, 2014
Journal articles hal-02905860v1
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Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press

Nicolas Jonckheere , Isabelle van Seuningen
Tumor Biology, 2014, 35 (4), pp.3941-3942. ⟨10.1007/s13277-013-1390-y⟩
Journal articles inserm-02371186v1
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The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways

Solange Tréhoux , Bélinda Duchêne , Nicolas Jonckheere , Isabelle van Seuningen
Biochemical and Biophysical Research Communications, 2014, ⟨10.1016/j.bbrc.2014.12.025⟩
Journal articles hal-02905690v1
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Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells

Michael Perrais , Christel Rousseaux , Marie-Paule Ducourouble , René Courcol , Pascal Vincent
Gastric Cancer, 2014, 17, pp.235-246. ⟨10.1007/s10120-013-0267-5⟩
Journal articles hal-02905802v1
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Membrane-bound mucin modular domains: from structure to function.

Nicolas Jonckheere , Nicolas Skrypek , Frédéric Frénois , Isabelle van Seuningen
Biochimie, 2013, 95 (6), pp.1077-86. ⟨10.1016/j.biochi.2012.11.005⟩
Journal articles inserm-00807818v1
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Operatively induced chronic reflux in rats: A suitable model for studying esophageal carcinogenesis?

Caroline Gronnier , Emilie Bruyère , Guillaume Piessen , Nicolas Briez , Jérôme Bot
Journal articles hal-02905869v1

Estradiol Represses the GD3 Synthase Gene ST8SIA1 Expression in Human Breast Cancer Cells by Preventing NFκB Binding to ST8SIA1 Promoter.

Marie Bobowski , Audrey Vincent , Agata Steenackers , Florent Colomb , Isabelle van Seuningen
PLoS ONE, 2013, 8 (4), pp.e62559. ⟨10.1371/journal.pone.0062559⟩
Journal articles hal-00819798v1
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The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.

Nicolas Skrypek , Bélinda Duchêne , Mohamed Hebbar , Emmanuelle Leteurtre , Isabelle van Seuningen
Oncogene, 2013, 32 (13), pp.1714-23. ⟨10.1038/onc.2012.179⟩
Journal articles inserm-00807837v1
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Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway

David Vincent , Johann Gout , Nicolas Chuvin , Vanessa Arfi , Roxane M. Pommier
American Journal of Pathology, 2012, 180 (6), pp.2214-2221. ⟨10.1016/j.ajpath.2012.02.006⟩
Journal articles hal-02954464v1

Membrane-bound mucin modular domains: From structure to function

Nicolas Jonckheere , Frédéric Frénois , Isabelle van Seuningen , Nicolas Q1 , Nicolas Skrypek
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012, ⟨10.1016/j.biochi.2012.11.005⟩
Journal articles hal-02905700v1

Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon

Mirte Streppel , Audrey Vincent , Radha Mukherjee , Nathaniel Campbell , Shih-Hsun Chen
Human Pathology, 2012, 43 (10), pp.1755-1763. ⟨10.1016/j.humpath.2012.01.005⟩
Journal articles hal-03313777v1
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Mucin Muc2 Deficiency and Weaning Influences the Expression of the Innate Defense Genes Reg3b, Reg3c and Angiogenin-4

Nanda Burger-van Paassen , Linda M P Loonen , Janneke Witte-Bouma , Anita Korteland-van Male , Adrianus C J M de Bruijn
PLoS ONE, 2012, 7 (6), pp.e38798. ⟨10.1371/journal.pone.0038798⟩
Journal articles hal-02905863v1
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The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.

Nicolas Jonckheere , Nicolas Skrypek , Johann Merlin , Anne Frédérique Dessein , Patrick Dumont
PLoS ONE, 2012, 7 (2), pp.e32232. ⟨10.1371/journal.pone.0032232⟩
Journal articles inserm-00807830v1
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GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

Nicolas Jonckheere , Audrey Vincent , Hélène Franquet-Ansart , Janneke Witte-Bouma , Anita Korteland-van Male
BBA - Biochimica et Biophysica Acta, 2012, 1819 (8), pp.869-76. ⟨10.1016/j.bbagrm.2012.04.003⟩
Journal articles inserm-00807845v1
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On the epigenetic origin of cancer stem cells

Audrey Vincent , Isabelle van Seuningen
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012, ⟨10.1016/j.bbcan.2012.03.009⟩
Journal articles hal-02905665v1
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The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.

Nicolas Jonckheere , Amélie Velghe , Marie-Paule Ducourouble , Marie-Christine Copin , Ingrid B. Renes
FEBS Journal, 2011, 278 (2), pp.282-94. ⟨10.1111/j.1742-4658.2010.07945.x⟩
Journal articles inserm-00807850v1
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The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein

Emilie Bruyère , Nicolas Jonckheere , Frédéric Frénois , Christophe Mariette , Isabelle van Seuningen
Biochemical and Biophysical Research Communications, 2011, pp.325-329. ⟨10.1016/j.bbrc.2011.08.095⟩
Journal articles hal-02905689v1

Colonic gene expression patterns of mucin muc2 knockout mice reveal various phases in colitis development1

Peng Lu , Nanda Burger-van Paassen , Maria van Der Sluis , Janneke Witte-Bouma , Jean-Pierre Kerckaert
Inflammatory Bowel Diseases, 2011, 17 (10), pp.2047-2057. ⟨10.1002/ibd.21592⟩
Journal articles hal-03313788v1
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Complex interplay between {beta}-catenin signalling and Notch effectors in intestinal tumorigenesis.

Grégory Peignon , Aurélie Durand , Wulfran Cacheux , Olivier Ayrault , Benoît Terris
Gut, 2011, 60 (2), pp.166-76. ⟨10.1136/gut.2009.204719⟩
Journal articles inserm-00553865v1

Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice

Nanda Burger-van Paassen , Maria van Der Sluis , Janneke Bouma , Anita Korteland-van Male , Peng Lu
AJP - Gastrointestinal and Liver Physiology, 2011, 301 (4), pp.G667-G678. ⟨10.1152/ajpgi.00199.2010⟩
Journal articles hal-03313786v1
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Mucins and Pancreatic Cancer

Nicolas Jonckheere , Nicolas Skrypek , Isabelle van Seuningen
Cancers, 2010, 2, pp.1794-1812. ⟨10.3390/cancers2041794⟩
Journal articles inserm-00807873v1
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Transcript Profiling of Elf5 +/2 Mammary Glands during Pregnancy Identifies Novel Targets of Elf5

Renee L Rogers , Isabelle van Seuningen , Jodee Gould , Paul J Hertzog , Matthew J Naylor
Journal articles hal-02905862v1

Signal Pathway of 17β-Estradiol–Induced MUC5B Expression in Human Airway Epithelial Cells

Hye Joung Choi , Yoo-Sam Chung , Hyun Jik Kim , Uk Yeol Moon , Yeon Ho Choi
American Journal of Respiratory Cell and Molecular Biology, 2009, 40 (2), pp.168-178. ⟨10.1165/rcmb.2007-0377OC⟩
Journal articles hal-03313791v1
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Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking

Willy Morelle , Laurence Stechly , Sabine Andre , Isabelle van Seuningen , Nicole Porchet
Biological Chemistry, 2009, 390, pp.529 - 544. ⟨10.1515/BC.2009.075⟩
Journal articles hal-02905705v1

MUC1, a New Hypoxia Inducible Factor Target Gene, Is an Actor in Clear Renal Cell Carcinoma Tumor Progression

Sébastien Aubert , Valérie Fauquette , Brigitte Hémon , Réjane Lepoivre , Nicolas Briez
Cancer Research, 2009, 69 (14), pp.5707-5715. ⟨10.1158/0008-5472.CAN-08-4905⟩
Journal articles hal-03313790v1

Intrauterine growth restriction alters postnatal colonic barrier maturation in rats

Pascale Fanca-Berthon , Catherine Michel , Anthony Pagniez , Martine Rival , Isabelle van Seuningen
Pediatric Research, 2009, 66 (1), pp.47-52. ⟨10.1203/PDR.0b013e3181a2047e⟩
Journal articles hal-02662866v1
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Clinical impact of MUC1 and MUC4 expression in Barrett-associated oesophageal adenocarcinoma

G. Piessen , A. Wacrenier , N. Briez , Jean-Pierre Triboulet , Isabelle van Seuningen
Journal of Clinical Pathology, 2009, 62, pp.1144-1146. ⟨10.1136/jcp.2008.060780⟩
Journal articles hal-02905828v1
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Qu’est ce que l’épigénétique ? Stratégies d’étude et application au cancer

Isabelle van Seuningen
Annales de Pathologie, 2009, 29 (5), pp.S28-S30. ⟨10.1016/j.annpat.2009.07.009⟩
Journal articles hal-03313794v1
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The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers

Nicolas Jonckheere , Isabelle van Seuningen
Journal articles hal-02905696v1

Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression.

Nicolas Jonckheere , Valérie Fauquette , Laurence Stechly , Nathalie Saint-Laurent , Sébastien Aubert
British Journal of Cancer, 2009, 101 (4), pp.637-44. ⟨10.1038/sj.bjc.6605190⟩
Journal articles inserm-00410436v1
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Epigenetics, stem cells and epithelial cell fate

Audrey Vincent , Isabelle van Seuningen
Differentiation, 2009, pp.99-107. ⟨10.1016/j.diff.2009.07.002⟩
Journal articles hal-02905791v1
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The regulation of the intestinal mucin MUC2 expression by short chain fatty acids: implications for epithelial protection

Nanda Burger-van Paassen , Audrey Vincent , Patrycja J Puiman , Maria van Der Sluis , Janneke Bouma
Biochemical Journal, 2009, 420 (2), pp.211-219. ⟨10.1042/BJ20082222⟩
Journal articles hal-00479129v1
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Mucins: a new family of epigenetic biomarkers in epithelial cancers

Isabelle van Seuningen , Audrey Vincent
Expert opinion on medical diagnostics, 2009, 3, pp.411 - 427. ⟨10.1517/17530050902852697⟩
Journal articles hal-02905792v1
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Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases

Audrey Vincent , Marie-Paule Ducourouble , Isabelle Van Seuningen
FASEB Journal, 2008, 22 (8), pp.3035-3045. ⟨10.1096/fj.07-103390⟩
Journal articles hal-02905794v1

Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice

Maria van Der Sluis , Janneke Bouma , Audrey Vincent , Anna Velcich , Kermit Carraway
Laboratory Investigation, 2008, 88 (6), pp.634-642. ⟨10.1038/labinvest.2008.28⟩
Journal articles hal-03313909v1

Resistin-like molecule β regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice

Rim Belharbi Krimi , Larissa Kotelevets , Laurent Dubuquoy , Pascale Plaisancié , Francine Walker
Inflammatory Bowel Diseases, 2008, 14 (7), pp.931-941. ⟨10.1002/ibd.20420⟩
Journal articles hal-03313912v1
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IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x} epitopes in the human bronchial mucosa

Sophie Groux-Degroote , Marie-Ange Krzewinski-Recchi , Aurélie Cazet , Audrey Vincent , Sylvain Lehoux
Biochemical Journal, 2008, 410 (1), pp.213-223. ⟨10.1042/BJ20070958⟩
Journal articles hal-00478849v1

IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines

Raquel Mejías-Luque , Sandra Peiró , Audrey Vincent , Isabelle van Seuningen , Carme de Bolós
Biochimica et Biophysica Acta - Molecular Cell Research, 2008, 1783 (10), pp.1728-1736. ⟨10.1016/j.bbamcr.2008.05.020⟩
Journal articles hal-03313911v1
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Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in Apc Min/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways

Kiyoshi Yamaguchi , Maria Cekanova , Michael F Mcentee , Joo-Heon Yoon , Susan M Fischer
Molecular Cancer Therapeutics, 2008, ⟨10.1158/1535-7163.MCT-08-0173⟩
Journal articles hal-02905848v1
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Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase

Christophe Mariette , Guillaume Piessen , Emmanuelle Leteurtre , Brigitte Hemon , Isabelle van Seuningen
Journal articles hal-02905866v1
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Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells

Maria van Der Sluis , Audrey Vincent , Janneke Bouma , Anita Korteland-van Male , Johannes B van Goudoever
Biochemical and Biophysical Research Communications, 2008, ⟨10.1016/j.bbrc.2008.02.158⟩
Journal articles hal-02905687v1
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The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies

Nicolas Jonckheere , Isabelle Van Seuningen
Critical Review in Oncogenesis, 2008, 14 (2-3), pp.177-196. ⟨10.1615/CritRevOncog.v14.i2-3.30⟩
Journal articles hal-02905788v1

Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic cancer cell proliferation.

Valérie Fauquette , Sébastien Aubert , Sophie Groux-Degroote , Brigitte Hemon , Nicole Porchet
Carcinogenesis / CARCINOGENESIS(LONDON); Carcinogenesis (Oxford), 2007, 28 (11), pp.2305-12. ⟨10.1093/carcin/bgm158⟩
Journal articles hal-00164934v1