IV

ISABELLE VAN SEUNINGEN

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Publications

Image document

MUC1 Drives the Progression and Chemoresistance of Clear Cell Renal Carcinomas

Emma Bourdon , Thomas Swierczewski , Marine Goujon , Nihad Boukrout , Sandy Fellah et al.
Cancers, 2024, 16 (2), pp.391. ⟨10.3390/cancers16020391⟩
Article dans une revue inserm-04479812 v1
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Emerging paradigms and recent progress in targeting ErbB in cancers

Nicolas Stoup , Maxime Liberelle , Nicolas Lebegue , Isabelle Van Seuningen
Trends in Pharmacological Sciences, 2024, Trends in Pharmacological Sciences, 45 (6), pp.552-576. ⟨10.1016/j.tips.2024.04.009⟩
Article dans une revue (article de synthèse) hal-04621567 v1
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A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice

Alexandre Quilbe , Rami Mustapha , Belinda Duchêne , Abhishek Kumar , Elisabeth Werkmeister et al.
Frontiers in Immunology, 2023, 14, pp.1267279. ⟨10.3389/fimmu.2023.1267279⟩
Article dans une revue hal-04469183 v1
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ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Julien Cicero , Sarah Trouvilliez , Martine Palma , Gaetan Ternier , Laurine Decoster et al.
Experimental Hematology & Oncology, 2023, 12 (1), pp.104. ⟨10.1186/s40164-023-00463-6⟩
Article dans une revue hal-04334490 v2
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Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?

Arnaud Jannin , Anne-Frédérique Dessein , Christine Do Cao , Marie-Christine Vantyghem , Benjamin Chevalier et al.
Frontiers in Endocrinology, 2023, 14, ⟨10.3389/fendo.2023.1248575⟩
Article dans une revue hal-04273585 v1
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A Double-Negative Feedback Interaction between miR-21 and PPAR-α in Clear Renal Cell Carcinoma

Marine Goujon , Justine Woszczyk , Kelly Gaudelot , Thomas Swierczewski , Sandy Fellah et al.
Cancers, 2022, 14 (3), pp.795. ⟨10.3390/cancers14030795⟩
Article dans une revue inserm-03729282 v1
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TRPM7 Modulates Human Pancreatic Stellate Cell Activation.

Julie Auwercx , Philippe Kischel , Thibaut Lefebvre , Nicolas Jonckheere , Alison Vanlaeys et al.
Cells, 2022, 11 (14), pp.2255. ⟨10.3390/cells11142255⟩
Article dans une revue hal-03740502 v1
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The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

Nicolas Stoup , Maxime Liberelle , Céline Schulz , Sumeyye Cavdarli , Romain Vasseur et al.
Cancers, 2021, 13 (22), pp.5746. ⟨10.3390/cancers13225746⟩
Article dans une revue hal-03641795 v1
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Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma

Nihad Boukrout , Mouloud Souidi , Fatima Lahdaoui , Belinda Duchêne , Bernadette Neve et al.
Cancers, 2021, 13 (24), pp.6197. ⟨10.3390/cancers13246197⟩
Article dans une revue hal-03777017 v1
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A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms

Elsa Hadj Bachir , Charles Poiraud , Sonia Paget , Nicolas Stoup , Soumaya El Moghrabi et al.
Biology of the Cell, 2021, 114 (1), pp.32-55. ⟨10.1111/boc.202100003⟩
Article dans une revue hal-03369738 v2
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Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sda synthase) gene: B4GALNT2 is transcriptionally regulated by ETS1

Cindy Wavelet-Vermuse , Sophie Groux-Degroote , Dorothée Vicogne , Virginie Cogez , Giulia Venturi et al.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2021, 1864 (11-12), pp.194747. ⟨10.1016/j.bbagrm.2021.194747⟩
Article dans une revue hal-03345208 v1
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Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers

Nicolas Jonckheere , Audrey Vincent , Bernadette Neve , Isabelle van Seuningen
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021, 1876 (1), pp.188538. ⟨10.1016/j.bbcan.2021.188538⟩
Article dans une revue hal-03294583 v1
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Mg2+ Transporters in Digestive Cancers

Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain et al.
Nutrients, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩
Article dans une revue hal-03195960 v1
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Fabricating Silicon Resonators for Analysing Biological Samples

Momoko Kumemura , Deniz Pekin , Vivek Anand Menon , Isabelle van Seuningen , Dominique Collard et al.
Micromachines, 2021, 12 (12), pp.1546. ⟨10.3390/mi12121546⟩
Article dans une revue (article de synthèse) hal-03501246 v1
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Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish

Ludivine Raby , Pamela Völkel , Shaghayegh Hasanpour , Julien Cicero , Robert-Alain Toillon et al.
Cells, 2021, 10 (11), pp.3142. ⟨10.3390/cells10113142⟩
Article dans une revue hal-04488645 v1

MUC1 Mitigates Renal Injury and Inflammation in Endotoxin-Induced Acute Kidney Injury by Inhibiting the TLR4-MD2 Axis and Reducing Pro-inflammatory Macrophages Infiltration

Jean-Baptiste Gibier , Thomas Swierczewski , Marie Csanyi , Brigitte Hemon , Francois Glowacki et al.
Shock, 2021, 56 (4), pp.629-638. ⟨10.1097/SHK.0000000000001742⟩
Article dans une revue hal-03379151 v1

Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells

Marjolaine Bauzone , Mouloud Souidi , Anne-Frédérique Dessein , Maxence Wisztorski , Audrey Vincent et al.
Molecular Cancer Research, 2021, 19 (4), pp.612-622. ⟨10.1158/1541-7786.MCR-20-0462⟩
Article dans une revue hal-04284692 v1

EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway?

Maxime Liberelle , Nicolas Jonckheere , Patricia Melnyk , Isabelle van Seuningen , Nicolas Lebègue
Journal of Medicinal Chemistry, 2020, 63 (10), pp.5074-5088. ⟨10.1021/acs.jmedchem.9b02001⟩
Article dans une revue hal-02955348 v1
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Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface

Lucie Coppin , Arnaud Jannin , Emilie Ait Yahya , Caroline Thuillier , Céline Villenet et al.
Cell Death and Disease, 2020, 11 (5), pp.360. ⟨10.1038/s41419-020-2556-3⟩
Article dans une revue hal-03060582 v1
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Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival

Nicolas Jonckheere , Julie Auwercx , Elsa Hadj Bachir , Lucie Coppin , Nihad Boukrout et al.
Cancers, 2020, 12 (11), pp.3309. ⟨10.3390/cancers12113309⟩
Article dans une revue hal-03003452 v2

Long non-coding RNAs: the tentacles of chromatin remodeler complexes

Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen
Cellular and Molecular Life Sciences, 2020, 78 (4), pp.1139-1161. ⟨10.1007/s00018-020-03646-0⟩
Article dans une revue hal-03195963 v1
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti , Satoru Yonekura , Connie P. M. Duong , Marion Picard , Gladys Ferrere et al.
Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩
Article dans une revue hal-03313676 v1
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Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia.

Mélanie Lambert , M Alioui , Samy Jambon , Sabine Depauw , Isabelle Van Seuningen et al.
Cancers, 2019, 11 (6), pp.837. ⟨10.3390/cancers11060837⟩
Article dans une revue (article de synthèse) hal-04549198 v1

Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia.

Mélanie Lambert , Meryem Alioui , Samy Jambon , Sabine Depauw , Isabelle van Seuningen et al.
Cancers, 2019, 11 (6), pp.837. ⟨10.3390/cancers11060837⟩
Article dans une revue hal-02358430 v1
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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required

Nicolas Jonckheere , Isabelle van Seuningen
Annals of translational medicine, 2019, 7 (S1), pp.S43-S43. ⟨10.21037/atm.2019.03.01⟩
Article dans une revue inserm-02341315 v1
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Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies

Audrey Vincent , Aïcha Ouelkdite-Oumouchal , Mouloud Souidi , Julie Leclerc , Bernadette Neve et al.
World Journal of Stem Cells, 2019, 11 (11), pp.920-936. ⟨10.4252/wjsc.v11.i11.920⟩
Article dans une revue inserm-02351996 v1
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MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis

Maxime Liberelle , Romain Magnez , Xavier Thuru , Yamina Bencheikh , Séverine Ravez et al.
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-53099-0⟩
Article dans une revue hal-02407901 v1

Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype

Mehdi El Amrani , François Corfiotti , Matthieu Corvaisier , Romain Vasseur , Maxence Fulbert et al.
Molecular Carcinogenesis, 2019, 58 (11), pp.1985-1997. ⟨10.1002/mc.23090⟩
Article dans une revue inserm-02352000 v1
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TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

Vincent Drubay , Nicolas Skrypek , Lucie Cordiez , Romain Vasseur , Céline Schulz et al.
Cancers, 2018, 10 (8), pii: E254. ⟨10.3390/cancers10080254⟩
Article dans une revue inserm-02341320 v1
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Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.

Nicolas Jonckheere , Isabelle van Seuningen
Journal of Translational Medicine, 2018, 16 (1), pp.259. ⟨10.1186/s12967-018-1632-2⟩
Article dans une revue hal-02341297 v1
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Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer

Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen
Cancers, 2018, 10 (11), pp.440. ⟨10.3390/cancers10110440⟩
Article dans une revue inserm-02341333 v1
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Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers

Michaël Duruisseaux , Martine Antoine , Nathalie Rabbe , Anita Rodenas , Anne Mc Leer-Florin et al.
Lung Cancer, 2017, 109, pp.92-100. ⟨10.1016/j.lungcan.2017.05.007⟩
Article dans une revue hal-01535623 v1

Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway

Fatima Lahdaoui , Mathieu Messager , Audrey Vincent , Flora Hec , Anne Gandon et al.
Biochemical Journal, 2017, 474 (22), pp.3733-3746. ⟨10.1042/BCJ20170348⟩
Article dans une revue inserm-02341337 v1
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Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Rémi Porte , Laurye van Maele , Natalia Muñoz-Wolf , Benoit Foligné , Laure Dumoutier et al.
Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩
Article dans une revue inserm-01529315 v1

Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma

Kelly Gaudelot , Jean-Baptiste Gibier , Nicolas Pottier , Brigitte Hémon , Isabelle van Seuningen et al.
Tumor Biology, 2017, 39 (7), pp.101042831770737. ⟨10.1177/1010428317707372⟩
Article dans une revue hal-03313744 v1
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Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells

Lucie Coppin , Audrey Vincent , Frédéric Frénois , Belinda Duchêne , Fatima Lahdaoui et al.
Scientific Reports, 2017, 7, pp.43927. ⟨10.1038/srep43927⟩
Article dans une revue hal-01534451 v1

Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase

Jean-Baptiste Gibier , Brigitte Hemon , Melanie Fanchon , Kelly Gaudelot , Nicolas Pottier et al.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, 1863 (6), pp.1336 - 1349. ⟨10.1016/j.bbadis.2017.03.023⟩
Article dans une revue inserm-01833348 v1
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The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting

Nicolas Jonckheere , Romain Vasseur , Isabelle Van Seuningen
Critical Reviews in Oncology/Hematology, 2017, 111, pp.7-19. ⟨10.1016/j.critrevonc.2017.01.002⟩
Article dans une revue inserm-02341607 v1
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The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential

Florence Renaud , Christophe Mariette , Audrey Vincent , Agnès Wacrenier , Vincent Maunoury et al.
International Journal of Cancer, 2016, 138, pp.1472-1481. ⟨10.1002/ijc.29891⟩
Article dans une revue hal-02905823 v1
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Hemidesmosome integrity protects the colon against colitis and colorectal cancer

Adèle de Arcangelis , Hussein Hamade , Fabien Alpy , Sylvain Normand , Emilie Bruyère et al.
Gut, 2016, 66 (10), pp.gutjnl--2015--310847. ⟨10.1136/gutjnl-2015-310847⟩
Article dans une revue hal-01538539 v1

Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse

Matthieu Corvaisier , Marjolaine Bauzone , François Corfiotti , Florence Renaud , Mehdi El Amrani et al.
Oncotarget, 2016, 7 (35), pp.56699-56712. ⟨10.18632/oncotarget.11057⟩
Article dans une revue hal-03313749 v1

Suitability of Surgically Induced Chronic Reflux in Rats for Studying Esophageal Carcinogenesis

Caroline Gronnier , Guillaume Piessen , Emmanuelle Leteurtre , Isabelle van Seuningen , Christophe Mariette
Annals of Surgery, 2015, 261 (5), pp.e140-e141. ⟨10.1097/SLA.0000000000000474⟩
Article dans une revue hal-03313754 v1
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Targeting MUC4 in pancreatic cancer: miRNAs

Nicolas Jonckheere , Fatima Lahdaoui , Isabelle van Seuningen
Oncoscience, 2015, 2 (10), pp.799-800. ⟨10.18632/oncoscience.249⟩
Article dans une revue hal-02905858 v1
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The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

Nicolas Skrypek , Romain Vasseur , Audrey Vincent , Bélinda Duchêne , Isabelle van Seuningen et al.
Oncotarget, 2015, 6 (13), pp.10853-1067. ⟨10.18632/oncotarget.3414⟩
Article dans une revue inserm-02341515 v1
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MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer

Florence Renaud , Audrey Vincent , Christophe Mariette , Michel Crépin , Laurence Stechly et al.
International Journal of Cancer, 2015, 136, pp.2811 - 2821. ⟨10.1002/ijc.29342⟩
Article dans une revue hal-02905819 v1
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The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways

Romain Vasseur , Nicolas Skrypek , Belinda Duchêne , Florence Renaud , Daniel Martínez-Maqueda et al.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2015, 1849 (12), pp.1375-1384. ⟨10.1016/j.bbagrm.2015.10.014⟩
Article dans une revue hal-02906327 v1
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Cryosectioning the intestinal crypt-villus axis: An ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells

Audrey Vincent , Catherine Kazmierczak , Belinda Duchêne , Nicolas Jonckheere , Emmanuelle Leteurtre et al.
Stem Cell Research, 2015, 14, ⟨10.1016/j.scr.2014.12.002⟩
Article dans une revue hal-02905864 v1
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Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells

Solange Tréhoux , Fatima Lahdaoui , Yannick Delpu , Florence Renaud , Emmanuelle Leteurtre et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2015, ⟨10.1016/j.bbamcr.2015.05.033⟩
Article dans une revue hal-02905657 v1
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Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival

Thibault Desurmont , Nicolas Skrypek , Alain Duhamel , Nicolas Jonckheere , Guillaume Millet et al.
Cancer Science, 2015, 106 (3), pp.262-269. ⟨10.1111/cas.12603⟩
Article dans une revue hal-02954490 v1
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MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway

Audrey Bouillez , Viviane Gnemmi , Kelly Gaudelot , Brigitte Hemon , Bélinda Ringot et al.
Oncotarget, 2014
Article dans une revue hal-02905860 v1
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Mucins and tumor resistance to chemotherapeutic drugs

Nicolas Jonckheere , Nicolas Skrypek , Isabelle Van Seuningen
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014, 1846 (1), pp.142-151. ⟨10.1016/j.bbcan.2014.04.008⟩
Article dans une revue inserm-02341531 v1
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Of autophagy and in vivo pancreatic carcinogenesis: The p53 status matters!

Nicolas Jonckheere , Audrey Vincent , Isabelle Van Seuningen
Clinics and Research in Hepatology and Gastroenterology, 2014, 38 (4), pp.423-425. ⟨10.1016/j.clinre.2014.04.009⟩
Article dans une revue inserm-02341594 v1
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The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways

Solange Tréhoux , Bélinda Duchêne , Nicolas Jonckheere , Isabelle van Seuningen
Biochemical and Biophysical Research Communications, 2014, ⟨10.1016/j.bbrc.2014.12.025⟩
Article dans une revue hal-02905690 v1
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Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

Xavier Tréton , Eric Pedruzzi , Cécile Guichard , Yannick Ladeiro , Shirin Sedghi et al.
PLoS ONE, 2014, 9 (7), pp.e101669. ⟨10.1371/journal.pone.0101669⟩
Article dans une revue hal-03313755 v1
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Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells

Michael Perrais , Christel Rousseaux , Marie-Paule Ducourouble , René Courcol , Pascal Vincent et al.
Gastric Cancer, 2014, 17, pp.235-246. ⟨10.1007/s10120-013-0267-5⟩
Article dans une revue hal-02905802 v1
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Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press

Nicolas Jonckheere , Isabelle van Seuningen
Tumor Biology, 2014, 35 (4), pp.3941-3942. ⟨10.1007/s13277-013-1390-y⟩
Article dans une revue inserm-02371186 v1
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MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway

Audrey Bouillez , Viviane Gnemmi , Kelly Gaudelot , Brigitte Hémon , Bélinda Ringot et al.
Oncotarget, 2014, 5 (3), pp.754-763. ⟨10.18632/oncotarget.1768⟩
Article dans une revue hal-03313775 v1
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Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth

Audrey Vincent , Seung-Mo Hong , Chaoxin Hu , Noriyuki Omura , Angela Young et al.
Oncotarget, 2014, 5 (9), pp.2575-2587. ⟨10.18632/oncotarget.1842⟩
Article dans une revue hal-02905879 v1

MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter

Viviane Gnemmi , Audrey Bouillez , Kelly Gaudelot , Brigitte Hémon , Bélinda Ringot et al.
Cancer Letters, 2014, 346 (2), pp.225-236. ⟨10.1016/j.canlet.2013.12.029⟩
Article dans une revue hal-03313770 v1
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The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells

Caroline Gronnier , Emilie Bruyère , Fatima Lahdaoui , Nicolas Jonckheere , Michael Perrais et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2014, ⟨10.1016/j.bbamcr.2014.06.021⟩
Article dans une revue hal-02905652 v1

MUC1 Expression in Papillary Thyroid Carcinoma Is Associated with BRAF Mutation and Lymph Node Metastasis; the Latter is the Most Important Risk Factor of Relapse

Florence Renaud , Viviane Gnemmi , Patrick Devos , Sébastien Aubert , Michel Crépin et al.
Thyroid, 2014, 24 (9), pp.1375-1384. ⟨10.1089/thy.2013.0594⟩
Article dans une revue hal-03313761 v1
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Membrane-bound mucin modular domains: from structure to function.

Nicolas Jonckheere , Nicolas Skrypek , Frédéric Frénois , Isabelle van Seuningen
Biochimie, 2013, 95 (6), pp.1077-86. ⟨10.1016/j.biochi.2012.11.005⟩
Article dans une revue inserm-00807818 v1

Estradiol Represses the GD3 Synthase Gene ST8SIA1 Expression in Human Breast Cancer Cells by Preventing NFκB Binding to ST8SIA1 Promoter.

Marie Bobowski , Audrey Vincent , Agata Steenackers , Florent Colomb , Isabelle van Seuningen et al.
PLoS ONE, 2013, 8 (4), pp.e62559. ⟨10.1371/journal.pone.0062559⟩
Article dans une revue hal-00819798 v1
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The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.

Nicolas Skrypek , Bélinda Duchêne , Mohamed Hebbar , Emmanuelle Leteurtre , Isabelle van Seuningen et al.
Oncogene, 2013, 32 (13), pp.1714-23. ⟨10.1038/onc.2012.179⟩
Article dans une revue inserm-00807837 v1
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Operatively induced chronic reflux in rats: A suitable model for studying esophageal carcinogenesis?

Caroline Gronnier , Emilie Bruyère , Guillaume Piessen , Nicolas Briez , Jérôme Bot et al.
Article dans une revue hal-02905869 v1

Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon

Mirte Streppel , Audrey Vincent , Radha Mukherjee , Nathaniel Campbell , Shih-Hsun Chen et al.
Human Pathology, 2012, 43 (10), pp.1755-1763. ⟨10.1016/j.humpath.2012.01.005⟩
Article dans une revue hal-03313777 v1
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Mucin Muc2 Deficiency and Weaning Influences the Expression of the Innate Defense Genes Reg3b, Reg3c and Angiogenin-4

Nanda Burger-van Paassen , Linda M P Loonen , Janneke Witte-Bouma , Anita Korteland-van Male , Adrianus C J M de Bruijn et al.
PLoS ONE, 2012, 7 (6), pp.e38798. ⟨10.1371/journal.pone.0038798⟩
Article dans une revue hal-02905863 v1

Membrane-bound mucin modular domains: From structure to function

Nicolas Jonckheere , Frédéric Frénois , Isabelle van Seuningen , Nicolas Q1 , Nicolas Skrypek et al.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012, ⟨10.1016/j.biochi.2012.11.005⟩
Article dans une revue hal-02905700 v1
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GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

Nicolas Jonckheere , Audrey Vincent , Hélène Franquet-Ansart , Janneke Witte-Bouma , Anita Korteland-van Male et al.
BBA - Biochimica et Biophysica Acta, 2012, 1819 (8), pp.869-76. ⟨10.1016/j.bbagrm.2012.04.003⟩
Article dans une revue inserm-00807845 v1
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The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.

Nicolas Jonckheere , Nicolas Skrypek , Johann Merlin , Anne Frédérique Dessein , Patrick Dumont et al.
PLoS ONE, 2012, 7 (2), pp.e32232. ⟨10.1371/journal.pone.0032232⟩
Article dans une revue inserm-00807830 v1
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On the epigenetic origin of cancer stem cells

Audrey Vincent , Isabelle van Seuningen
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012, ⟨10.1016/j.bbcan.2012.03.009⟩
Article dans une revue hal-02905665 v1
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Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway

David Vincent , Johann Gout , Nicolas Chuvin , Vanessa Arfi , Roxane M. Pommier et al.
American Journal of Pathology, 2012, 180 (6), pp.2214-2221. ⟨10.1016/j.ajpath.2012.02.006⟩
Article dans une revue hal-02954464 v1
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The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.

Nicolas Jonckheere , Amélie Velghe , Marie-Paule Ducourouble , Marie-Christine Copin , Ingrid B. Renes et al.
FEBS Journal, 2011, 278 (2), pp.282-94. ⟨10.1111/j.1742-4658.2010.07945.x⟩
Article dans une revue inserm-00807850 v1

Colonic gene expression patterns of mucin muc2 knockout mice reveal various phases in colitis development1

Peng Lu , Nanda Burger-van Paassen , Maria van Der Sluis , Janneke Witte-Bouma , Jean-Pierre Kerckaert et al.
Inflammatory Bowel Diseases, 2011, 17 (10), pp.2047-2057. ⟨10.1002/ibd.21592⟩
Article dans une revue hal-03313788 v1

Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice

Nanda Burger-van Paassen , Maria van Der Sluis , Janneke Bouma , Anita Korteland-van Male , Peng Lu et al.
AJP - Gastrointestinal and Liver Physiology, 2011, 301 (4), pp.G667-G678. ⟨10.1152/ajpgi.00199.2010⟩
Article dans une revue hal-03313786 v1
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Complex interplay between {beta}-catenin signalling and Notch effectors in intestinal tumorigenesis.

Grégory Peignon , Aurélie Durand , Wulfran Cacheux , Olivier Ayrault , Benoît Terris et al.
Gut, 2011, 60 (2), pp.166-76. ⟨10.1136/gut.2009.204719⟩
Article dans une revue inserm-00553865 v1
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The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein

Emilie Bruyère , Nicolas Jonckheere , Frédéric Frénois , Christophe Mariette , Isabelle van Seuningen
Biochemical and Biophysical Research Communications, 2011, pp.325-329. ⟨10.1016/j.bbrc.2011.08.095⟩
Article dans une revue hal-02905689 v1
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Transcript Profiling of Elf5 +/2 Mammary Glands during Pregnancy Identifies Novel Targets of Elf5

Renee L Rogers , Isabelle van Seuningen , Jodee Gould , Paul J Hertzog , Matthew J Naylor et al.
Article dans une revue hal-02905862 v1
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Mucins and Pancreatic Cancer

Nicolas Jonckheere , Nicolas Skrypek , Isabelle van Seuningen
Cancers, 2010, 2, pp.1794-1812. ⟨10.3390/cancers2041794⟩
Article dans une revue inserm-00807873 v1

Signal Pathway of 17β-Estradiol–Induced MUC5B Expression in Human Airway Epithelial Cells

Hye Joung Choi , Yoo-Sam Chung , Hyun Jik Kim , Uk Yeol Moon , Yeon Ho Choi et al.
American Journal of Respiratory Cell and Molecular Biology, 2009, 40 (2), pp.168-178. ⟨10.1165/rcmb.2007-0377OC⟩
Article dans une revue hal-03313791 v1
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Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking

Willy Morelle , Laurence Stechly , Sabine Andre , Isabelle van Seuningen , Nicole Porchet et al.
Biological Chemistry, 2009, 390, pp.529 - 544. ⟨10.1515/BC.2009.075⟩
Article dans une revue hal-02905705 v1

Intrauterine growth restriction alters postnatal colonic barrier maturation in rats

Pascale Fanca-Berthon , Catherine Michel , Anthony Pagniez , Martine Rival , Isabelle van Seuningen et al.
Pediatric Research, 2009, 66 (1), pp.47-52. ⟨10.1203/PDR.0b013e3181a2047e⟩
Article dans une revue hal-02662866 v1
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Clinical impact of MUC1 and MUC4 expression in Barrett-associated oesophageal adenocarcinoma

G. Piessen , A. Wacrenier , N. Briez , Jean-Pierre Triboulet , Isabelle van Seuningen et al.
Journal of Clinical Pathology, 2009, 62, pp.1144-1146. ⟨10.1136/jcp.2008.060780⟩
Article dans une revue istex hal-02905828 v1
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Epigenetics, stem cells and epithelial cell fate

Audrey Vincent , Isabelle van Seuningen
Differentiation, 2009, pp.99-107. ⟨10.1016/j.diff.2009.07.002⟩
Article dans une revue hal-02905791 v1
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Mucins: a new family of epigenetic biomarkers in epithelial cancers

Isabelle van Seuningen , Audrey Vincent
Expert opinion on medical diagnostics, 2009, 3, pp.411 - 427. ⟨10.1517/17530050902852697⟩
Article dans une revue hal-02905792 v1

Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression.

Nicolas Jonckheere , Valérie Fauquette , Laurence Stechly , Nathalie Saint-Laurent , Sébastien Aubert et al.
British Journal of Cancer, 2009, 101 (4), pp.637-44. ⟨10.1038/sj.bjc.6605190⟩
Article dans une revue inserm-00410436 v1
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Qu’est ce que l’épigénétique ? Stratégies d’étude et application au cancer

Isabelle van Seuningen
Annales de Pathologie, 2009, 29 (5), pp.S28-S30. ⟨10.1016/j.annpat.2009.07.009⟩
Article dans une revue hal-03313794 v1
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The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers

Nicolas Jonckheere , Isabelle van Seuningen
Article dans une revue hal-02905696 v1
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The regulation of the intestinal mucin MUC2 expression by short chain fatty acids: implications for epithelial protection

Nanda Burger-van Paassen , Audrey Vincent , Patrycja J Puiman , Maria van Der Sluis , Janneke Bouma et al.
Biochemical Journal, 2009, 420 (2), pp.211-219. ⟨10.1042/BJ20082222⟩
Article dans une revue hal-00479129 v1

MUC1, a New Hypoxia Inducible Factor Target Gene, Is an Actor in Clear Renal Cell Carcinoma Tumor Progression

Sébastien Aubert , Valérie Fauquette , Brigitte Hémon , Réjane Lepoivre , Nicolas Briez et al.
Cancer Research, 2009, 69 (14), pp.5707-5715. ⟨10.1158/0008-5472.CAN-08-4905⟩
Article dans une revue hal-03313790 v1
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IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x} epitopes in the human bronchial mucosa

Sophie Groux-Degroote , Marie-Ange Krzewinski-Recchi , Aurélie Cazet , Audrey Vincent , Sylvain Lehoux et al.
Biochemical Journal, 2008, 410 (1), pp.213-223. ⟨10.1042/BJ20070958⟩
Article dans une revue hal-00478849 v1

Resistin-like molecule β regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice

Rim Belharbi Krimi , Larissa Kotelevets , Laurent Dubuquoy , Pascale Plaisancié , Francine Walker et al.
Inflammatory Bowel Diseases, 2008, 14 (7), pp.931-941. ⟨10.1002/ibd.20420⟩
Article dans une revue hal-03313912 v1

Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice

Maria van Der Sluis , Janneke Bouma , Audrey Vincent , Anna Velcich , Kermit Carraway et al.
Laboratory Investigation, 2008, 88 (6), pp.634-642. ⟨10.1038/labinvest.2008.28⟩
Article dans une revue hal-03313909 v1
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The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies

Nicolas Jonckheere , Isabelle Van Seuningen
Critical Review in Oncogenesis, 2008, 14 (2-3), pp.177-196. ⟨10.1615/CritRevOncog.v14.i2-3.30⟩
Article dans une revue hal-02905788 v1
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Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells

Maria van Der Sluis , Audrey Vincent , Janneke Bouma , Anita Korteland-van Male , Johannes B van Goudoever et al.
Biochemical and Biophysical Research Communications, 2008, ⟨10.1016/j.bbrc.2008.02.158⟩
Article dans une revue hal-02905687 v1

IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines

Raquel Mejías-Luque , Sandra Peiró , Audrey Vincent , Isabelle van Seuningen , Carme de Bolós
Biochimica et Biophysica Acta - Molecular Cell Research, 2008, 1783 (10), pp.1728-1736. ⟨10.1016/j.bbamcr.2008.05.020⟩
Article dans une revue hal-03313911 v1
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Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in Apc Min/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways

Kiyoshi Yamaguchi , Maria Cekanova , Michael F Mcentee , Joo-Heon Yoon , Susan M Fischer et al.
Molecular Cancer Therapeutics, 2008, ⟨10.1158/1535-7163.MCT-08-0173⟩
Article dans une revue hal-02905848 v1
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IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines

Raquel Mejías-Luque , Sandra Peiró , Audrey Vincent , Isabelle van Seuningen , Carme de Bolós
Biochimica et Biophysica Acta - Molecular Cell Research, 2008, ⟨10.1016/j.bbamcr.2008.05.020⟩
Article dans une revue hal-02905649 v1
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Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase

Christophe Mariette , Guillaume Piessen , Emmanuelle Leteurtre , Brigitte Hemon , Isabelle van Seuningen et al.
Article dans une revue hal-02905866 v1
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Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases

Audrey Vincent , Marie-Paule Ducourouble , Isabelle Van Seuningen
FASEB Journal, 2008, 22 (8), pp.3035-3045. ⟨10.1096/fj.07-103390⟩
Article dans une revue hal-02905794 v1
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Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α

Guillaume Piessen , Nicolas Jonckheere , Audrey Vincent , Brigitte Hemon , Marie-Paule Ducourouble et al.
Biochemical Journal, 2007, 402, pp.81 - 91. ⟨10.1042/BJ20061461⟩
Article dans une revue hal-02905759 v1

Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation.

Pierre Lesimple , Isabelle van Seuningen , Marie-Pierre Buisine , Marie-Christine Copin , Margitta Hinz et al.
American Journal of Respiratory Cell and Molecular Biology, 2007, 36 (3), pp.296-303. ⟨10.1165/rcmb.2006-0270OC⟩
Article dans une revue inserm-00143069 v1

Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic cancer cell proliferation.

Valérie Fauquette , Sébastien Aubert , Sophie Groux-Degroote , Brigitte Hemon , Nicole Porchet et al.
Carcinogenesis / CARCINOGENESIS(LONDON); Carcinogenesis (Oxford), 2007, 28 (11), pp.2305-12. ⟨10.1093/carcin/bgm158⟩
Article dans une revue hal-00164934 v1
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The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells

Nicolas Jonckheere , Audrey Vincent , Michaël Perrais , Marie-Paule Ducourouble , Anita Korteland-van Male et al.
Journal of Biological Chemistry, 2007, ⟨10.1074/jbc.M700905200⟩
Article dans une revue hal-02905844 v1

Metaplasia A Transdifferentiatlon Process that Facilitates Cancer Development: The Model of Gastric Intestinal Metaplasia

Patricia Mesquita , Raquel Almeida , Nuno Lunet , Celso Reis , Luis Filipe Santos Silva et al.
Critical Review in Oncogenesis, 2006, 12 (1-2), pp.3-26. ⟨10.1615/CritRevOncog.v12.i1-2.20⟩
Article dans une revue hal-03313915 v1

Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Maria van Der Sluis , Barbara A.E. de Koning , Adrianus C.J.M. de Bruijn , Anna Velcich , Jules P.P. Meijerink et al.
Gastroenterology, 2006, 131 (1), pp.117-129. ⟨10.1053/j.gastro.2006.04.020⟩
Article dans une revue hal-03313916 v1
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Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1{alpha}

Guillaume Piessen , Nicolas Jonckheere , Audrey Vincent , Brigitte Hémon , Marie-Paule Ducourouble et al.
Biochemical Journal, 2006, 402 (1), pp.81-91. ⟨10.1042/BJ20061461⟩
Article dans une revue hal-00478670 v1

Evidence for a functional genetic polymorphism of the human retinoic acid–metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida

Emmanuel Rat , Ingrid Billaut-Laden , Delphine Allorge , Jean-Marc Lo-Guidice , Marie Tellier et al.
Birth Defects Research Part A: Clinical and Molecular Teratology, 2006, 76 (6), pp.491-498. ⟨10.1002/bdra.20275⟩
Article dans une revue istex hal-02954484 v1

The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation.

Marjolaine Bauzone , Mouloud Souidi , Anne-Frédérique Dessein , Maxence Wisztorski , Audrey Vincent et al.
Nature Cell Biology, 2006, 8 (4), pp.278-84. ⟨10.1038/ncb1373⟩
Article dans une revue istex inserm-04278051 v1

OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells

Raquel Almeida , José Almeida , Michal Shoshkes , Nuno Mendes , Patrícia Mesquita et al.
Journal of Pathology, 2005, 207 (4), pp.396-401. ⟨10.1002/path.1861⟩
Article dans une revue hal-03313917 v1

Synergistic induction of the MUC4 mucin gene by interferon-γ and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways

Mahefatiana Andrianifahanana , Anshu Agrawal , Ajay Singh , Nicolas Moniaux , Isabelle van Seuningen et al.
Oncogene, 2005, 24 (40), pp.6143-6154. ⟨10.1038/sj.onc.1208756⟩
Article dans une revue hal-03313918 v1
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The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells

Valérie Fauquette , Michael Perrais , Sylvain Cerulis , Nicolas Jonckheere , Marie-Paule Ducourouble et al.
Biochemical Journal, 2005, 386, pp.35 - 45
Article dans une revue hal-02905757 v1

The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells

Valérie Fauquette , Michael Perrais , Sylvain Cerulis , Nicolas Jonckheere , Marie-Paule Ducourouble et al.
Biochemical Journal, 2005, 386 (1), pp.35-45. ⟨10.1042/BJ20040706⟩
Article dans une revue hal-02954487 v1

Esophageal Carcinoma: Prognostic Differences between Squamous Cell Carcinoma And Adenocarcinoma

Christophe Mariette , Laetitia Finzi , Guillaume Piessen , Isabelle van Seuningen , Jean Pierre Triboulet
World Journal of Surgery, 2005, 29 (1), pp.39-45. ⟨10.1007/s00268-004-7542-x⟩
Article dans une revue istex hal-03313920 v1
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A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-b in pancreatic carcinogenesis

Nicolas Jonckheere , Michael Perrais , Christophe Mariette , Surinder K Batra , Jean-Pierre Aubert et al.
Oncogene, 2004, 23, pp.5729 - 5738. ⟨10.1038/sj.onc.1207769⟩
Article dans une revue hal-02905851 v1
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The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells

Maria van Der Sluis , Monique H M Melis , Nicolas Jonckheere , Marie-Paule Ducourouble , Hans A Bü Ller A et al.
Biochemical and Biophysical Research Communications, 2004, 325, pp.952 - 960. ⟨10.1016/j.bbrc.2004.10.108⟩
Article dans une revue hal-02905675 v1

Coordinated Expression of MUC2 and CDX-2 in Mucinous Carcinomas of the Lung Can Be Explained by the Role of CDX-2 as Transcriptional Regulator of MUC2

Patrícia Mesquita , Raquel Almeida , Isabelle van Seuningen , Leonor David
American Journal of Surgical Pathology, 2004, 28 (9), pp.1254-1255. ⟨10.1097/01.pas.0000135517.50095.7f⟩
Article dans une revue hal-03313919 v1

Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Christophe Mariette , Michaël Perrais , Emmanuelle Leteurtre , Nicolas Jonckheere , Brigitte Hémon et al.
Biochemical Journal, 2004, 377 (3), pp.701-708. ⟨10.1042/bj20031132⟩
Article dans une revue hal-03314562 v1
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Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Christophe Mariette , Michael Perrais , Emmanuelle Leteurtre , Nicolas Jonckheere , Brigitte Hemon et al.
Biochemical Journal, 2004, 377, pp.701 - 708
Article dans une revue hal-02905712 v1
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Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1

Nicolas Jonckheere , Maria van Der Sluis , Amélie Velghe , Marie-Pierre Buisine , Marjolein Sutmuller et al.
Biochemical Journal, 2004, 377, pp.797 - 808. ⟨10.1042/BJ20030948⟩
Article dans une revue hal-02905751 v1

Factors Affecting Postoperative Course and Survival After En Bloc Resection for Esophageal Carcinoma

Christophe Mariette , Guillaume Taillier , Isabelle van Seuningen , Jean-Pierre Triboulet
Annals of Thoracic Surgery, 2004, 78 (4), pp.1177-1183. ⟨10.1016/j.athoracsur.2004.02.068⟩
Article dans une revue istex hal-03314560 v1
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Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1

Nicolas Jonckheere , Maria van Der Sluis , Amélie Velghe , Marie-Pierre Buisine , Marjolein Sutmuller et al.
Biochemical Journal, 2004, 377, pp.797 - 808
Article dans une revue hal-02905715 v1
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Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Michael Perrais , Brigitte Hemon , Isabelle van Seuningen , Christophe Mariette , Michaël Perrais et al.
Biochemical Journal, 2004, 377, pp.701 - 708
Article dans une revue hal-02905748 v1
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Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines

Patrícia Mesquita , Nicolas Jonckheere , Raquel Almeida , Marie-Paule Ducourouble , Jacinta Serpa et al.
Journal of Biological Chemistry, 2003, ⟨10.1074/jbc.M309019200⟩
Article dans une revue hal-02905842 v1

Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease

Christophe Mariette , Jean-Michel Balon , Guillaune Piessen , Sylvain Fabre , Isabelle van Seuningen et al.
Cancer, 2003, 97 (7), pp.1616-1623. ⟨10.1002/cncr.11228⟩
Article dans une revue hal-03316294 v1
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Induction of MUC2 and MUC5AC Mucins by Factors of the Epidermal Growth Factor (EGF) Family Is Mediated by EGF Receptor/Ras/Raf/Extracellular Signal-regulated Kinase Cascade and Sp1

Michael Perrais , Pascal Pigny , Marie-Christine Copin , Jean-Pierre Aubert , Isabelle van Seuningen
Journal of Biological Chemistry, 2002, 277, pp.32258 - 32267. ⟨10.1074/jbc.M204862200⟩
Article dans une revue hal-02905840 v1

Influence of TNFα on the sialylation of mucins produced by a transformed cell line MM-39 derived from human tracheal gland cells

Philippe Delmotte , Sophie Degroote , Marc Merten , Isabelle van Seuningen , Annie Bernigaud et al.
Glycoconjugate Journal, 2001, 18 (6), pp.487-497. ⟨10.1023/A:1016038219183⟩
Article dans une revue istex hal-03316059 v1

Influence of TNFα on the sialylation of mucins produced by a transformed cell line MM-39 derived from human tracheal gland cells

Philippe Delmotte , Sophie Degroote , Marc Merten , Isabelle van Seuningen , Annie Bernigaud et al.
Glycoconjugate Journal, 2001, 18 (6), pp.487-497. ⟨10.1023/A:1016038219183⟩
Article dans une revue istex hal-03314995 v1

Transcriptional regulation of the 11p15 mucin genes. towards new biological tools in human therapy, in inflammatory diseases and cancer?

Isabelle Van Seuningen
Frontiers in Bioscience, 2001, 6 (1), pp.d1216. ⟨10.2741/seuning⟩
Article dans une revue hal-03314990 v1

Influence of culture conditions on the α1,2-fucosyltransferase and MUC gene expression of a transformed cell line MM-39 derived from human tracheal gland cells

Philippe Delmotte , Sophie Degroote , Marc Merten , Annie Bernigaud , Isabelle van Seuningen et al.
Biochimie, 2001, 83 (8), pp.749-755. ⟨10.1016/S0300-9084(01)01320-7⟩
Article dans une revue istex hal-03316057 v1
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TRANSCRIPTIONAL REGULATION OF THE 11P15 MUCIN GENES. TOWARDS NEW BIOLOGICAL TOOLS IN HUMAN THERAPY, IN INFLAMMATORY DISEASES AND CANCER?

Isabelle van Seuningen , Pascal Pigny , Michael Perrais , Nicole Porchet , Jean-Pierre Aubert
Frontiers in Bioscience, 2001, 6
Article dans une revue hal-02905799 v1

Influence of culture conditions on the α1,2-fucosyltransferase and MUC gene expression of a transformed cell line MM-39 derived from human tracheal gland cells

Philippe Delmotte , Sophie Degroote , Marc Merten , Annie Bernigaud , Isabelle van Seuningen et al.
Biochimie, 2001, 83 (8), pp.749-755. ⟨10.1016/S0300-9084(01)01320-7⟩
Article dans une revue istex hal-03314993 v1
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Characterization of Human Mucin Gene MUC4 Promoter

Michael Perrais , Pascal Pigny , Marie-Paule Ducourouble , Daniè Le Petitprez , Nicole Porchet et al.
Journal of Biological Chemistry, 2001, ⟨10.1074/jbc.M104204200⟩
Article dans une revue hal-02905838 v1
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Aberrant Expression of Human Mucin Gene MUC5B in Gastric Carcinoma and Cancer Cells

Michael Perrais , Pascal Pigny , Marie-Pierre Buisine , Nicole Porchet , Jean-Pierre Aubert et al.
Journal of Biological Chemistry, 2001, ⟨10.1074/jbc.M010534200⟩
Article dans une revue hal-02905839 v1

Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells

Isabelle Van Seuningen , Michaël Perrais , Pascal Pigny , Nicole Porchet , Jean-Pierre Aubert
Biochemical Journal, 2000, 348 (3), pp.675-686. ⟨10.1042/bj3480675⟩
Article dans une revue hal-03316039 v1
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Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells

Isabelle van Seuningen , Michaël Perrais , Pascal Pigny , Nicole Porchet , Jean-Pierre Aubert
Biochemical Journal, 2000, 348, pp.675 - 686
Article dans une revue hal-02905746 v1

Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells

Isabelle Van Seuningen , Michaël Perrais , Pascal Pigny , Nicole Porchet , Jean-Pierre Aubert
Biochemical Journal, 2000, 348 (3), pp.675-686. ⟨10.1042/bj3480675⟩
Article dans une revue hal-03316061 v1

Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells

Isabelle Van Seuningen , Michaël Perrais , Pascal Pigny , Nicole Porchet , Jean-Pierre Aubert
Biochemical Journal, 2000, 348 (3), pp.675-686. ⟨10.1042/bj3480675⟩
Article dans une revue hal-03317695 v1
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Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells

Isabelle van Seuningen , Michaël Perrais , Pascal Pigny , Nicole Porchet , Jean-Pierre Aubert
Biochemical Journal, 2000, 348, pp.675 - 686
Article dans une revue hal-02905708 v1

Diverse molecular interactions of the hnRNP K protein

Karol Bomsztyk , Isabelle van Seuningen , Hideaki Suzuki , Oleg Denisenko , Jerzy Ostrowski
FEBS Letters, 1997, 403 (2), pp.113-115. ⟨10.1016/S0014-5793(97)00041-0⟩
Article dans une revue hal-03317710 v1

Genomic organization of the 3' region of the human mucin gene MUC5B.

Jean-Luc Desseyn , J P Aubert , Isabelle van Seuningen , N Porchet , A Laine
Journal of Biological Chemistry, 1997, 272 (27), pp.16873-1683. ⟨10.1074/jbc.272.27.16873⟩
Article dans une revue hal-02177047 v1

Identification of a 42-kDa Nuclear Factor (NF1-MUC5B) from HT-29 MTX Cells That Binds to the 3′ Region of Human Mucin GeneMUC5B

Pascal Pigny , Isabelle van Seuningen , Jean Luc Desseyn , Séverine Nollet , Nicole Porchet et al.
Biochemical and Biophysical Research Communications, 1996, 220 (1), pp.186-191. ⟨10.1006/bbrc.1996.0378⟩
Article dans une revue istex hal-03316289 v1

Zik1, a Transcriptional Repressor That Interacts with the Heterogeneous Nuclear Ribonucleoprotein Particle K Protein

Oleg Denisenko , Bruce O'Neill , Jerzy Ostrowski , Isabelle van Seuningen , Karol Bomsztyk
Journal of Biological Chemistry, 1996, 271 (44), pp.27701-27706. ⟨10.1074/jbc.271.44.27701⟩
Article dans une revue hal-03317709 v1

Human Mucin Genes Assigned to 11p15.5: Identification and Organization of a Cluster of Genes

Pascal Pigny , Veronique Guyonnet-Duperat , Alexander Hill , Wendy Pratt , Sylvie Galiegue-Zouitina et al.
Genomics, 1996, 38 (3), pp.340-352. ⟨10.1006/geno.1996.0637⟩
Article dans une revue istex hal-03316037 v1

The K Protein Domain That Recruits the Interleukin 1-responsive K Protein Kinase Lies Adjacent to a Cluster of c-Src and Vav SH3-binding Sites

Isabelle van Seuningen , Jerzy Ostrowski , Xose Bustelo , Paul Sleath , Karol Bomsztyk
Journal of Biological Chemistry, 1995, 270 (45), pp.26976-26985. ⟨10.1074/jbc.270.45.26976⟩
Article dans une revue hal-03317707 v1

Description of an IL-1-Responsive Kinase That Phosphorylates the K Protein. Enhancement of Phosphorylation by Selective DNA and RNA Motifs

Isabelle van Seuningen , Jerzy Ostrowski , Karol Bomsztyk
Biochemistry, 1995, 34 (16), pp.5644-5650. ⟨10.1021/bi00016a040⟩
Article dans une revue istex hal-03317708 v1

Western blotting of basic proteins after nondenaturing electrophoresis in acid conditions using the PhastSystem

Monique Davril , Marie-Paule Ducourouble , Isabelle Van-Seuningen
Electrophoresis, 1993, 14 (1), pp.876-880. ⟨10.1002/elps.11501401139⟩
Article dans une revue istex hal-03317698 v1

Involvement of a Signal Transduction Mechanism in ATP-induced Mucin Release from Cultured Airway Goblet Cells

K. Chul Kim , Qiao-Xi Zheng , Isabelle Van-Seuningen
American Journal of Respiratory Cell and Molecular Biology, 1993, 8 (2), pp.121-125. ⟨10.1165/ajrcmb/8.2.121⟩
Article dans une revue hal-03317696 v1

A rapid periodic acid-Schiff staining procedure for the detection of glycoproteins using the phastsystem

Isabelle Van-Seuningen , Monique Davril
Electrophoresis, 1992, 13 (1), pp.97-99. ⟨10.1002/elps.1150130119⟩
Article dans une revue istex hal-03317700 v1

Strong ionic interactions between mucins and two basic proteins, mucus proteinase inhibitor and lysozyme, in human bronchial secretions

Isabelle Van-Seuningen , Nicole Houdret , Annette Hayem , Monique Davril
International Journal of Biochemistry, 1992, 24 (2), pp.303-311. ⟨10.1016/0020-711X(92)90262-Y⟩
Article dans une revue istex hal-03317704 v1

Analysis of the conformation and stability of human bronchial lysozyme by circular dichroism

Isabelle Van-Seuningen , Annette Hayem , Monique Davril
International Journal of Biochemistry, 1992, 24 (4), pp.593-598. ⟨10.1016/0020-711X(92)90332-U⟩
Article dans une revue istex hal-03317702 v1

Separation of the two domains of human mucus proteinase inhibitor: Inhibitory activity is only located in the car☐y-terminal domain

Isabelle Van-Seuningen , Monique Davril
Biochemical and Biophysical Research Communications, 1991, 179 (3), pp.1587-1592. ⟨10.1016/0006-291X(91)91755-2⟩
Article dans une revue istex hal-03317705 v1

Electrotransfer of basic proteins from nondenaturing polyacrylamide acid gels to nitrocellulose: Detection of enzymatic and inhibitory activities and retention of protein antigenicity

Isabelle Van-Seuningen , Monique Davril
Analytical Biochemistry, 1990, 186 (2), pp.306-311. ⟨10.1016/0003-2697(90)90085-N⟩
Article dans une revue istex hal-03317706 v1

L’expression ectopique de CDX2 dans le pancréas exerce un effet prooncogénique, dépendant du domaine de liaison à l’ADN mais indépendant dudomaine de transactivation

Bénédicte Caron , Jeanny Tchiloemba-Biakou , Nicolas Jonckheere , Andréa Thévenot , Mohamed Elati et al.
Club d'Etude des Cellules Epithéliales Digestives, CECED, Mar 2024, Montpellier (34000), France
Communication dans un congrès hal-04534767 v1

L’alpha-kinase de TRPM7 : un acteur impliqué dans la migration, l’invasion et la TEM des cellules cancéreuses pancréatiques humaines.

Julie Auwercx , Bernadette Neve , Alison Vanlaeys , Sylvie Brassart-Pasco , Mathilde Fourgeaud et al.
15èmes journées scientifiques du Cancéropôle Nord-Ouest, Deauville, 2023., 2023, Deauville, France
Communication dans un congrès hal-04466150 v1

Development of an instrumented microfluidic system to study chemosensitivity in pancreatic ductal adenocarcinoma

Felix Royer , Thomas Meynard , Orégane Bajeux , Robin Houssier , Ørjan Grøttem Martinsen et al.
Journée André Verbert 2023, Nov 2023, Lille, France
Communication dans un congrès hal-04537958 v1

Discovery of the first peptide ligand targeting the EGF2 domain of MUC4 that rescues accessibility and sensitivity of pancreatic cancer cells to Herceptin targeted therapy

Isabelle Van Seuningen , Nicolas Stoup , Maxime Liberelle , Leila Moum , Nicolas Renault et al.
XXXVIIèmes Journées Scientifiques Annuelles du Club Français du Pancréas (CFP), Club Français du Pancréas; La Cité des Échanges, Marcq-en-Barœul, Sep 2023, Lille, France
Communication dans un congrès hal-04547238 v1

Développement d’un modèle de co-culture d’adénocarcinome pancréatique canalaire au sein d’un système microfluidique pour l’étude des interactions tumeur-stroma et de la chimiorésistance

Thomas Meynard , Felix Royer , Sonia Paget , Alejandra Mogrovejo Valdivia , Nathalie Maubon et al.
40 ème réunion du Club d’étude de la cellule épithéliale digestive, Mar 2023, Strasbourg, France
Communication dans un congrès hal-04537961 v1

Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex in pancreatic cancer.

Nicolas Stoup , Maxime Liberelle , Nicolas Renault , Patricia Melnyk , Nicolas Jonckheere et al.
3rd ONCOLille phD Days (3 ème journée des doctorants ONCOLille), ONCOLille, Mar 2022, Lille, France
Communication dans un congrès hal-04547102 v1

Neurotrophins promotes brain metastasis of triple negative breast cancer through Src kinase family activation

Julien Cicero , Sarah Trouvilliez , Martine Palma , Gaetan Ternier , Laurine Decoster et al.
1st ONCOLille days 2022, Nov 2022, Lille, France
Communication dans un congrès hal-03853963 v1

TRPM7 Modulates Human Pancreatic Stellate Cell Activation.

Julie Auwercx , Philippe Kischel , Thibault Lefebvre , Nicolas Jonckheere , Alison Vanlaeys et al.
XVI International Magnesium Symposium (SDRM)., Jun 2022, Glasgow, United Kingdom
Communication dans un congrès hal-04465334 v1

Structure-functions relationship and therapeutic targeting of the MUC4-ErbB2 complex in pancreatic cancer

Isabelle Van Seuningen , Nicolas Stoup , Maxime Liberelle , Céline Schulz , Leila Moum et al.
16th International Meeting for Mucins in Health and Diseases (Mucin Conference), International Mucin Organizing Committee, Jul 2022, Utrecht (Netherlands), Netherlands
Communication dans un congrès hal-04547327 v1

Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex to reduce pancreatic cancer activity in vitro.

Nicolas Stoup , Maxime Liberelle , Nicolas Renault , Patricia Melnyk , Nicolas Jonckheere et al.
XXXIXèmes Journées Scientifiques Annuelles du Club d’étude des cellules épithéliales digestives (CECED), Club d’étude des cellules épithéliales digestives; Faculté de médecine de LYON, Mar 2022, Lyon, France
Communication dans un congrès hal-04547168 v1

In Vitro Study of the Role of TRPM7 Kinase in Metastatic Mechanisms of Pancreatic Cancer Cells.

Julie Auwercx , Alison Vanlaeys , Frédéric Hague , Isabelle Dhennin-Duthille , Philippe Kischel et al.
1 st ONCOLille days, Oct 2022, Lille, France
Communication dans un congrès hal-04466179 v1
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Engineering microscale biomimetic hydroscaffold for dynamic three-dimensional modeling of pancreatic cancer

Frederick De Miollis , Zied Souguir , Charles Poiraud , Joseph de Saxce , Lucie Dercourt et al.
2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS), Jan 2021, Gainesville, United States. pp.407-410, ⟨10.1109/MEMS51782.2021.9375317⟩
Communication dans un congrès hal-03450959 v1

Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex in pancreatic cancer.

Nicolas Stoup , Maxime Liberelle , Nicolas Renault , Patricia Melnyk , Nicolas Jonckheere et al.
13èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest, Cancéropole Nord-Ouest; Centre International de DEAUVILLE, Oct 2021, Deauville, France
Communication dans un congrès hal-04546733 v1

Rôle du long ARN non-codant UCA1 dans le caractère souche des cellules cancéreuses coliques; analyse d’une méthode monocellulaire pour caractériser la formation des tumorosphères

Bernadette Neve , Deniz Pekin , Mouloud Souidi , Audrey Vincent , Isabelle Van Seuningen
Journées scientifiques du CNO, Cancéropôle Nord-Ouest, Oct 2021, Deauville, France
Communication dans un congrès hal-04538342 v1

The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets

Nicolas Stoup , Maxime Liberelle , Céline Schulz , Romain Vasseur , Romain Magnez et al.
2021 American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, American Society for Biochemistry and Molecular Biology, Apr 2021, Virtuel Conference, France
Communication dans un congrès hal-04547288 v1

3D structural resolution and therapeutic targeting of the MUC4-ErbB2 oncogenic complex in pancreatic cancer: Carbene Footprinting approach.

Nicolas Stoup , Maxime Liberelle , Julien Franck , Nicolas Renault , Patricia Melnyk et al.
Journée Scientifique Annuelle de l’Association française pour la recherche sur le cancer du pancréas (AFRCP), Association française pour la recherche sur le cancer du pancréas; Hopital Beaujon CLICHY, Nov 2021, Clichy, France
Communication dans un congrès hal-04546759 v1

Magnesium transporters: discovering new potential biomarkers in digestive cancers.

Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain et al.
XV International Magnesium Symposium (SDRM)., Jun 2021, online virtual meeting, United Kingdom
Communication dans un congrès hal-04465355 v1

The role of TRPM7 kinase-domain: Looking for new partners in pancreatic ductal adenocarcinoma.

Julie Auwercx , Alison Vanlaeys , Frédéric Hague , Philippe Kischel , Bernadette Neve et al.
CANTHER PhD Day 2021, CANcer Heterogeneity, Plasticity and Resistance to THERapies., Mar 2021, Lille (France), France
Communication dans un congrès inserm-04541485 v1

Pnliprp1 hypermethylation in human exocrine pancreas reveals a link between diabetes and pancreatic cancer

Amna Khamis , Mickael Canouil , Lorella Marselli , Raphaël Boutry , Mara Suleiman et al.
56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)., 2020, virtual meeting, United Kingdom
Communication dans un congrès hal-04465919 v1

Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers.

Alexandre Quilbe , Rami Mustapha , Belinda Duchêne , S Renaud , Clémentine de Schutter et al.
Club Français du Pancréas, 2019, Bron, France
Communication dans un congrès hal-04465692 v1

Roles of MUC4-miR-210 in pancreatic carcinogenesis and Chemotherapy resistance.

Nihad Boukrout , Fatima Lahdaoui , Céline Schulz , Romain Vasseur , Belinda Duchêne et al.
Mucins in health and disease (15th International Workshop on Carcinoma-associated Mucins), 2019, Cambridge, United Kingdom
Communication dans un congrès hal-04465368 v1

Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers

Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter et al.
4ème Journée Scientifique de l’Association pour la Recherche sur le Cancer du pancréas (AFRCP), 2018, Clichy, France
Communication dans un congrès hal-04465715 v1

Interactions MUC4-canaux ioniques TRPM7 et KCa3.1 dans l’adénocarcinome pancréatique

Alison Vanlaeys , Bernadette Neve , Mouloud Souidi , Isabelle Van Seuningen , Halima Ouadid-Ahidouch et al.
2ieme Journée nationale “canaux ioniques et cancer”, Canaux et Connexines dans le Cancer et les Cellules Souches (4CS), Jul 2018, Poitiers (FR), France
Communication dans un congrès inserm-04541464 v1

Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers

Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter et al.
11èmes journées scientifiques du Cancéropole Nord Ouest, 2018, Deauville, France
Communication dans un congrès hal-04465768 v1

Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers

Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter et al.
5th European Congress of Immunology, 2018, Amsterdam, Netherlands
Communication dans un congrès hal-04465749 v1

Strategy of inhibition of TRPM7 channel in pancreatic cancer cells by CRISPR/Cas9.

Alison Vanlaeys , Bernadette Neve , Mouloud Souidi , Isabelle van Seuningen , Halima Ouadid-Ahidouch et al.
4ème Journée Scientifique de l’Association pour la Recherche sur le Cancer du pancréas (AFRCP), 2018, Clichy, France
Communication dans un congrès hal-04465699 v1

The MUC4 membrane-bound mucin mediates FOLFIRINOX drugs resistance of human pancreatic cancer cells.

Nicolas Skrypek , Luc Kotzmann , Romain Vasseur , Fatima Lahdaoui , Belinda Duchêne et al.
Mucins in health and disease (13th International Workshop on Carcinoma-associated Mucins), 2015, Cambridge, United Kingdom
Communication dans un congrès hal-04465781 v1

Characterization of 2′-5′-oligoadenylate synthetase (OAS) genes as MUC4-associated new biomarkers in pancreatic adenocarcinoma

Nicolas Jonckheere , Diane Ghesquiere , Julie Auwercx , Lucie Coppin , Isabelle Van Seuningen
Mucins in health and Disease, Jun 2024, Gottenburg, Sweden
Poster de conférence hal-04594977 v1
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Single cell analysis for intrinsic stemness potential of cancer

Bernadette Neve , Aude Sivery , Isabelle Van Seuningen , Anthony Treizebré , Audrey Vincent
5th Sunrise meeting, May 2024, Ajaccio, France.
Poster de conférence hal-04589665 v1

Single cell analysis for intrinsic stemness potential of cancer cells

Bernadette Neve , Aude Sivery , Isabelle Van Seuningen , A. Treizebre , Audrey Vincent
5th SUNRiSE meeting (Heterogeneity and Plasticity in cancer), May 2024, Ajaccio - Corse, France
Poster de conférence hal-04547376 v1

Rôle de macroH2A1.2 dans l'aggressivité de l'adénocarcinome pancréatique

Laura Paviot , Lucas Degrave , Nihad Boukrout , Nicolas Jonckheere , Isabelle Van Seuningen et al.
16èmes journées scientifiques du Cancéropole Nord Ouest, May 2024, Deauville, France
Poster de conférence hal-04591731 v1

Development of an instrumented microfluidic system to study chemoresistance in pancreatic ductal adenocarcinoma

Thomas Meynard , Félix Royer , Orégane Bajeux , Robin Houssier , Clemens Wagner et al.
Microphysiological Systems World Summit 2023, Jun 2023, Berlin, Germany
Poster de conférence hal-04480724 v1

Le premier peptide ligand ciblant les domaines EGF de la mucine MUC4 restaure la sensibilité d’ErbB2 à l’Herceptin dans le cancer du pancréas

Nicolas Stoup , Maxime Liberelle , Nicolas Renault , Thomas Meynard , Patricia Melnyk et al.
15èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest, May 2023, Deauville, France
Poster de conférence hal-04547431 v1

Development of a 3D co-culture model within a microfluidic system to study pancreatic tumor stroma interactions and drug resistance.

Thomas Meynard , Felix Royer , Sonia Paget , Alejandra Mogrovejo Valdivia , Nathalie Maubon et al.
FEBS 2023, Jul 2023, Tours, France
Poster de conférence hal-04537951 v1

Développement d’un modèle de co-culture 3D d’adénocarcinome pancréatique canalaire au sein d’un système microfluidique pour l’étude des interactions tumeur-stroma et de la réponse aux traitements chimiothérapeutiques.

Thomas Meynard , Felix Royer , Sonia Paget , Zied Souguir , Antonino Bongiovani et al.
Cancéropôle Nord-Ouest 2023, May 2023, Deauville, France
Poster de conférence hal-04537954 v1

Développement d’un modèle de co-culture 3D d’adénocarcinome pancréatique canalaire au sein d’un système microfluidique pour l’étude des interactions tumeur-stroma et de la chimiorésistance.

Thomas Meynard , Felix Royer , Orégane Bajeux , Robin Houssier , Sonia Paget et al.
Club français du pancréas 2023, Sep 2023, Lille, France
Poster de conférence hal-04537949 v1

Développement d’un système microfluidique instrumenté pour l’étude de la chimiosensibilité de l’adénocarcinome pancréatique canalaire

Felix Royer , Thomas Meynard , Orégane Bajeux , Robin Houssier , Ørjan Grøttem Martinsen et al.
Club Français du Pancréas, Sep 2023, Lille, France
Poster de conférence hal-04537944 v1

L’alpha-kinase de TRPM7: comprendre son rôle dans les propriétés invasives de l’adénocarcinome canalaire pancréatique

Julie Auwercx , Alison Vanlaeys , Isabelle Dhennin-Duthille , Philippe Kischel , Frédéric Hague et al.
Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2022, 2022, Deauville, France
Poster de conférence hal-04465802 v1

Bioinformatics identification of key regulators associated with MUC4 expression in pancreatic adenocarcinoma.

Nicolas Jonckheere , Julie Auwercx , Elsa Hadj Bachir , Lucie Coppin , Audrey Vincent et al.
Mucins in health and Disease, Jul 2022, Utrecht (Netherland), Netherlands
Poster de conférence hal-04465160 v1

MUC4 interactants: to infinity and beyond ?

Nicolas Stoup , Tristan Girgin , Maxime Liberelle , Leila Moum , Nicolas Lebègue et al.
16th International Meeting for Mucins in Health and Diseases (Mucin Conference), Jul 2022, Utrecht (Netherlands), Netherlands
Poster de conférence hal-04547497 v1

Mechanobiological characterization of a 3D in vitro pancreatic ductal adenocarcinoma model and the study of tumor-stroma interaction.

Thomas Meynard , Felix Royer , Sonia Paget , Zied Souguir , Antonino Bongiovani et al.
ONCOLille days, Nov 2022, Lille, France
Poster de conférence hal-04537957 v1

Résolution structural 3D et ciblage thérapeutique du complexe oncogénique MUC4-ErbB2 dans le cancer du pancréas.

Nicolas Stoup , Maxime Liberelle , Julien Franck , Nicolas Renault , Patricia Melnyk et al.
14èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest (CNO), May 2022, Deauville, France
Poster de conférence hal-04547404 v1

The first peptide ligand targeting the EGF domains of MUC4 rescues Herceptin accessibility to ErbB2 in pancreatic cancer cells.

Nicolas Stoup , Maxime Liberelle , Nicolas Renault , Patricia Melnyk , Nicolas Jonckheere et al.
1er séminaire international de l’institut ONCOLILLE, Nov 2022, Lille, France
Poster de conférence hal-04548329 v1

Resensitizing ErbB2 to trastuzumab in pancreatic cancer : identification and characterization of the first peptide ligand targeting the MUC4EGF domains

Nicolas Stoup , Maxime Liberelle , Nicolas Renault , Patricia Melnyk , Nicolas Jonckheere et al.
16th International Meeting for Mucins in Health and Diseases (Mucin Conference), Jul 2022, Utrecht (Netherlands), Netherlands
Poster de conférence hal-04547486 v1

Abstract 2965: Epigenetic mechanisms involved in acquired resistance to combined chemotherapies in digestive cancer cells

Elsa Hadj Bachir , Charles Poiraud , Hugo Claux , Soumaya El Moghrabi , Sonia Paget et al.
AACR Annual Meeting 2022, 2022, New Orleans (Louisiana), United States. 82 (12_Supplement), pp.2965-2965, 2022, ⟨10.1158/1538-7445.AM2022-2965⟩
Poster de conférence hal-04465616 v1

Établissement d’une signature prédictive de la survie globale des patients atteints de cancer colique basée sur le profil d’expression d’enzymes responsables de modifications épigénétiques.

Elsa Hadj Bachir , Bernadette Neve , Guillaum Piessen , Emmanuelle Leteurtre , Florence Renaud et al.
Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2022, 2022, Deauville, France
Poster de conférence hal-04465808 v1

MUC4 interactants: to infinity and beyond.

Nicolas Stoup , Tristan Girgin , Maxime Liberelle , Leila Moum , Nicolas Jonckheere et al.
Mucins in health and Disease, Jul 2022, Utrecht (Netherland), Netherlands
Poster de conférence hal-04465179 v1

Development of a microfluidic system to study tumor-stroma interactions and drug sensitivity

Felix Royer , Thomas Meynard , Robin Houssier , Isabelle Van Seuningen , Vincent Senez
ONCOLille Days 2022, Nov 2022, Lille, France
Poster de conférence hal-04537947 v1

MAGNESIUM TRANSPORTERS EXPRESSION AND PROGNOSTIC IMPACT IN DIGESTIVE CANCERS

Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain et al.
Future Physiology 2021, Apr 2021, On line conference, United Kingdom
Poster de conférence hal-04465644 v1

Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex in pancreatic cancer

Nicolas Stoup , Maxime Liberelle , Nicolas Renault , Patricia Melnyk , Nicolas Jonckheere et al.
Congrès Annuel de la Société Française de Biochimie et Biologie Moléculaire (SFBBM), Jul 2021, Paris, France
Poster de conférence hal-04547378 v1

Abstract LB106: The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets

Nicolas Stoup , Maxime Liberelle , Céline Schulz , Romain Vasseur , Romain Magnez et al.
AACR Annual Meeting 2021, 2021, Philadelphia, United States. 81 (13_Supplement), pp.LB106-LB106, 2021, ⟨10.1158/1538-7445.AM2021-LB106⟩
Poster de conférence hal-04465601 v1

Expression des transporteurs au magnésium et impact pronostic dans les cancers digestifs.

Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain et al.
Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2021, 2021, Deauville, France
Poster de conférence hal-04465849 v1

Le rôle du domaine kinase de TRPM7 : A la recherche de nouveaux partenaires d’interaction dans l’adénocarcinome canalaire pancréatique.

Julie Auwercx , Alison Vanlaeys , Frédéric Hague , Philippe Kischel , Bernadette Neve et al.
Club Français du Pancréas, 2021, Bron, France
Poster de conférence hal-04465863 v1

MUC1: an actor in chemoresistance and a new therapeutic target in renal cell carcinoma

Thomas Swierczewski , Jean-Baptiste Gibier , Brigitte Hémon , Isabelle Van Seuningen , Viviane Gnemmi et al.
12ème journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France
Poster de conférence hal-04540853 v1

Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and resistance to chemotherapy.

Nihad Boukrout , Fatima Lahdaoui , Céline Schulz , Romain Vasseur , Belinda Duchêne et al.
Pancreatic cancer symposium, 2019, Toulouse, France
Poster de conférence hal-04465665 v1

Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance.

Nihad Boukrout , Fatima Lahdaoui , Céline Schulz , Romain Vasseur , Belinda Duchêne et al.
12èmes journées scientifiques du Cancéropôle Nord-Ouest, 2019, Deauville, France
Poster de conférence hal-04466063 v1

Evaluation in vitro et in vivo d'une Nouvelle Stratégie d’Immunothérapie ciblant la Galectine-9 dans un modèle de cancer pancréatique.

Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter et al.
12èmes journées scientifiques du Cancéropôle Nord-Ouest, 2019, Deauville, France
Poster de conférence hal-04466053 v1

Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers.

Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter et al.
11èmes journées scientifiques du Cancéropôle Nord-Ouest, 2018, Deauville, France
Poster de conférence hal-04466070 v1

MUC1: an actor in chemoresistance and a new therapeutic target in renal cell carcinoma

Brigitte Hémon , Thomas Swierczewski , Jean-Baptiste Gibier , Isabelle Van Seuningen , Viviane Gnemmi et al.
10 ème journées scientifiques du Cancéropôle Nord-Ouest, May 2018, Deauville, France
Poster de conférence hal-04540838 v1

Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance.

Nihad Boukrout , Fatima Lahdaoui , Céline Schulz , Romain Vasseur , Belinda Duchêne et al.
11èmes journées scientifiques du Cancéropôle Nord-Ouest, 2018, Deauville, France
Poster de conférence hal-04466077 v1

Analyzing lncRNA UCA1 in cancerous cells by targeted exon deletion based on CRISPR/Cas9.

Mouloud Souidi , Amandine Legrand , Isabelle Van Seuningen , Bernadette Neve
Genome Engineering and Synthetic Biology (3rd) conference, Jan 2018, Bruges, Belgique, Belgium
Poster de conférence hal-04538454 v1

Single-Cell Analysis May Shed New Lights on the Role of LncRNAs in Chemoresistance in Gastrointestinal Cancers

Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen
The Chemical Biology of Long Noncoding RNAs, 11, Springer International Publishing, pp.229-253, 2020, RNA Technologies, ⟨10.1007/978-3-030-44743-4_9⟩
Chapitre d'ouvrage inserm-04541444 v1

Reporter, Inducible And Synthetic Promoters: Engineering Tools To Study Gene Regulation And Biological Systems

Nicolas Jonckheere , Isabelle Van Seuningen
The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation, BENTHAM SCIENCE PUBLISHERS, pp.149-161, 2013, ⟨10.2174/9781608054923113010010⟩
Chapitre d'ouvrage hal-04541719 v1