jean-marc Brondello

30
Documents

Présentation

Tissue accumulation of p16INK4A-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). Indeed, these cell-cycle arrested cells affect tissue function and homestasis through cell-to-cell juxtacrine and paracrine specific mechanisms. Using in vivo transgenic murine models for senescence detection and depletion altogether with in vitro 2D and 3D culture conditions for osteoarticular cells, our group aims at:

  • identifying senescent articular joint cells that drive tissue degeneration
  • developing strategies to eliminate such cells in vitro and in vivo
  • restoring joint functions in elderly to delay prosthetic surgery

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Publications

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A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging

Charlène Iltis , Iryna Moskalevska , Antoine Debiesse , Laetitia Seguin , Christina Fissoun et al.

Nature Aging, 2025, 5, pp.219-236. ⟨10.1038/s43587-024-00776-z⟩

Article dans une revue hal-04949697v3
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Furan fatty acids supplementation in obese mice reverses hepatic steatosis and protects against cartilage degradation

Mathys Chaslin , Georges Maroun , Erwann Durand , Béatrice Bonafos , Said Assou et al.

Biomedicine and Pharmacotherapy, 2025, 187, 13p. ⟨10.1016/j.biopha.2025.118072⟩

Article dans une revue hal-05051861v1
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis

Damien Veret , Gautier Tejedor , Esther Perez , Alison Chomette , Maylis Farno et al.

Stem Cell Research and Therapy, 2025, 16 (1), pp.9. ⟨10.1186/s13287-024-04090-8⟩

Article dans une revue hal-04948767v1

Senescence-regulatory factors as novel circulating biomarkers and therapeutic targets in regenerative medicine for osteoarthritis

Georges Maroun , Christina Fissoun , Marina Villaverde , Jean-Marc Brondello , Yves-Marie Pers

Joint Bone Spine, 2024, 91 (2), pp.105640. ⟨10.1016/j.jbspin.2023.105640⟩

Article dans une revue hal-04948778v1
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Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients

Giuseppe Fusi , Michael Constantinides , Christina Fissoun , Lydiane Pichard , Yves-Marie Pers et al.

Biomedicines, 2023, 11 (7), pp.1994. ⟨10.3390/biomedicines11071994⟩

Article dans une revue hal-04949712v1

Osteoarthritis in time for senotherapeutics

Damien Veret , Christian Jorgensen , Jean-Marc Brondello

Joint Bone Spine, 2021, 88 (2), pp.105084. ⟨10.1016/j.jbspin.2020.105084⟩

Article dans une revue hal-03163864v1
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Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes

Olivier Malaise , Geneviève Paulissen , Céline Deroyer , Federica Ciregia , Christophe Poulet et al.

Journal of Clinical Medicine, 2021, 10 (22), pp.5331. ⟨10.3390/jcm10225331⟩

Article dans une revue hal-04958639v1
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Establishment of a collection of human pluripotent stem cell lines (iPSC) from mesenchymal stem cells (MSC) from three healthy elderly donors

Lydiane Pichard , Jean-Marc Brondello , Fabienne Becker , Romain Desprat , Frédéric de Ceuninck et al.

Stem Cell Research, 2021, 53, pp.102297. ⟨10.1016/j.scr.2021.102297⟩

Article dans une revue hal-03664523v1
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Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis

Lydiane Pichard , Jean-Marc Brondello , Fabienne Becker , Romain Desprat , Frédéric de Ceuninck et al.

Stem Cell Research, 2020, 44, pp.101721. ⟨10.1016/j.scr.2020.101721⟩

Article dans une revue hal-02961555v1
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Sénothérapies

Damien Veret , Jean-Marc Brondello

Médecine/Sciences, 2020, 36 (12), pp.1135-1142. ⟨10.1051/medsci/2020220⟩

Article dans une revue hal-03049534v1
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Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer

Patricia Luz-Crawford , Javier Hernandez , Farida Djouad , Noymar Luque-Campos , Andrès Caicedo et al.

Stem Cell Research and Therapy, 2019, 10 (1), pp.232. ⟨10.1186/s13287-019-1307-9⟩

Article dans une revue inserm-02376241v1
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Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis?

Jean-Marc Brondello , Farida Djouad , Christian Jorgensen

Cells, 2019, 8 (10), pp.1257. ⟨10.3390/cells8101257⟩

Article dans une revue hal-02555388v1

Taking in consideration the bystander effects of articular senescence

Jean-Marc Brondello , Yves-Marie Pers

Annals of translational medicine, 2019, 7 (S8), pp.S386-S386. ⟨10.21037/atm.2019.12.128⟩

Article dans une revue hal-04947712v1
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Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases

Yassin Tachikart , Olivier Malaise , Marcus Mumme , Christian Jorgensen , Jean-Marc Brondello

Biochemical Pharmacology, 2019, 165, pp.126-133. ⟨10.1016/j.bcp.2019.03.017⟩

Article dans une revue hal-02877478v1
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Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

Olivier Malaise , Yassin Tachikart , Michael Constantinides , Marcus Mumme , Rosanna Ferreira-Lopez et al.

Aging, 2019, 11 (20), pp.9128-9146. ⟨10.18632/aging.102379⟩

Article dans une revue hal-02551968v1
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Cibler les cellules sénescentes : Une révolution dans le traitement des pathologies ostéo-articulaires

Yassin Tachikart , Olivier Malaise , Michael Constantinides , Christian Jorgensen , Jean-Marc Brondello

Médecine/Sciences, 2018, Les Cahiers de Myologie, 34 (6-7), pp.547 - 553. ⟨10.1051/medsci/20183406014⟩

Article dans une revue hal-03179760v1
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Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis.

Paul Chuchana , Anne-Laure Mausset-Bonnefont , Marc Mathieu , Francisco Espinoza , Marisa Teigell et al.

Aging, 2018, 10 (6), pp.1442-1453. ⟨10.18632/aging.101481⟩

Article dans une revue hal-01834060v1
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Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

Marie-Luce Vignais , Andrès Caicedo , Jean-Marc Brondello , Christian Jorgensen

Stem Cells International, 2017, 2017, pp.6917941. ⟨10.1155/2017/6917941⟩

Article dans une revue hal-01759757v1

Senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?

Olivier Malaise , Yassin Tachikart , Jean-Marc Brondello

AME Medical Journal, 2017, 2, pp.161 - 161. ⟨10.21037/amj.2017.10.01⟩

Article dans une revue hal-01838428v1
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Cellular senescence impact on immune cell fate and function

Rita Vicente , Anne-Laure Mausset-Bonnefont , Christian Jorgensen , Pascale Louis-Plence , Jean-Marc Brondello

Aging Cell, 2016, 15 (3), pp.400 - 406. ⟨10.1111/acel.12455⟩

Article dans une revue hal-01834241v1
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MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

Andrès Caicedo , Vanessa Fritz , Jean-Marc Brondello , Mickaël Ayala , Indira Dennemont et al.

Scientific Reports, 2015, 5 (1), ⟨10.1038/srep09073⟩

Article dans une revue hal-01834600v1

FOXO3A Regulation by miRNA-29a Controls Chondrogenic Differentiation of Mesenchymal Stem Cells and Cartilage Formation

David Guérit , Jean-Marc Brondello , Paul Chuchana , Didier Philipot , Karine Toupet et al.

Stem Cells and Development, 2014, 23 (11), pp.1195 - 1205. ⟨10.1089/scd.2013.0463⟩

Article dans une revue hal-01836483v1
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p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodelling in osteoarthritis.

Didier Philipot , David Guérit , Daniela Platano , Paul Chuchana , Eleonora Olivotto et al.

Arthritis Research and Therapy, 2014, 16 (1), pp.R58. ⟨10.1186/ar4494⟩

Article dans une revue inserm-00983071v1

Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage

J. Basbous , Dora Knani , Nathalie Bonneaud , Dominique Giorgi , Jean-Marc Brondello et al.

Cell Cycle, 2012, 11 (12), pp.2380-9012. ⟨10.4161/cc.20858⟩

Article dans une revue hal-00705749v1
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Cellular Senescence is a Common Characteristic Shared by Preneoplasic and Osteo-Arthritic Tissue~!2009-12-06~!2010-01-18~!2010-02-11~!

Jean-Marc Brondello , Didier Philipot , Farida Djouad , Christian Jorgensen , Danièle Noel

The Open Rheumatology Journal, 2010, 4 (1), pp.10-14. ⟨10.2174/1874312901004010010⟩

Article dans une revue hal-05000154v1

Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisition regulated by microRNAs

Jan Gordeladze , Farida Djouad , Jean-Marc Brondello , D. Noel , Isabelle Duroux-Richard et al.

Acta Pharmacologica Sinica, 2009, 30 (10), pp.1369-1384. ⟨10.1038/aps.2009.143⟩

Article dans une revue hal-04989608v1
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Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy.

Claire Vinatier , Carine Bouffi , Christophe Merceron , Jan Gordeladze , Jean-Marc Brondello et al.

Current Stem Cell Research & Therapy, 2009, 4 (4), pp.318-29

Article dans une revue inserm-00423696v1
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Linking PCNA-dependent replication and ATR by human Claspin.

Jean-Marc Brondello , Bernard Ducommun , Anne Fernandez , Ned J. Lamb

Biochemical and Biophysical Research Communications, 2007, 354 (4), pp.1028-33. ⟨10.1016/j.bbrc.2007.01.091⟩

Article dans une revue inserm-00147047v1

DNA damage checkpoint kinase Chk2 triggers replicative senescence

Véronique Gire , Pierre Roux , David Wynford-Thomas , Jean-Marc Brondello , Vjekoslav Dulic

EMBO Journal, 2004, 23 (13), pp.2554-2563. ⟨10.1038/sj.emboj.7600259⟩

Article dans une revue hal-03763012v1