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JH

Jean-Marie HEYDEL

Professeur de Biochimie et de Biologie Moléculaire Circonscription Pharmacie UFR des Sciences de Santé Université de Bourgogne France
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Présentation

Jean-Marie Heydel currently works at the Centre des Sciences du Goût et de l’Alimentation (CSGA), University of Burgundy France. He is Professor in Biochemistry and molecular Biology at the University for Health Sciences in Dijon France. He has been continuously interested in Xenobiotic metabolism. Since 2005, he has led a working group investigating the function of XMEs in olfaction and taste. In the frame of transversal collaborations, he showed that XMEs are involved in the clearance of chemosensory molecules from the receptors environment and/or in the synthesis of chemosensory active metabolites both having significant consequences on perception (models: rodents, rabbit, drosophila, Human). His research interests currently focuse on xenobiotic metabolism at the brain interface, olfaction, peripheral physiology and biochemistry of smell and taste, animal and human volatilome.

Domaines de recherche


Publications

Flavour from the molecules to the behaviour

F. Neiers , Mathieu Schwartz , Jean-Marie Heydel , Boichot Valentin , Francis Canon
Food Science Meeting, May 2022, Valence, Spain
Communication dans un congrès hal-03828980v1

Molecules of the flavor

F. Neiers , Mathieu Schwartz , Jean-Marie Heydel , Valentin Boichot , Francis Canon
IATA Conference, Instituto de Agroquímica y Tecnología de Alimentos, Jun 2022, Valence, Spain
Communication dans un congrès hal-03827290v1

Role of human metabolizing enzymes in food perception

Boichot Valentin , Franck Ménétrier , Jean-Marie Heydel , Francis Canon , Mathieu Schwartz
FORTHEM Food Science Lab Workshop, Mar 2022, Palermo, Italy
Communication dans un congrès hal-03611500v1

Function of nasal odorant metabolism in vertebrate olfaction

Jean-Marie Heydel
Conférence ISIPCA, Jan 2021, Paris, France
Communication dans un congrès hal-03179876v1

How odorant metabolizing enzymes shape odor perception?

Jean-Marie Heydel
The International Symposium on Olfaction and Taste (ISOT), Aug 2020, virtual congress, United States
Communication dans un congrès hal-03053514v1

Implication des enzymes dans la perception chimio-sensorielle : une piste dans les troubles olfacto-gustatifs induits par des xénobiotiques ?

Marie-Chantal Canivenc-Lavier , Jean-Marie Heydel , Franck Ménétrier , Christine Belloir , Philippe Faure
Journées Nacre, Dec 2019, Paris, France
Communication dans un congrès hal-02944510v1

Function of nasal odorant metabolism in mammalian olfaction

Jean-Marie Heydel
40. annual meeting - association for chemoreception sciences (AChemS), Apr 2018, Bonita Springs, Florida, United States. 2 p
Communication dans un congrès hal-02735549v1

Les systèmes de détoxification dans le signal olfactif

Jean-Marie Heydel
Colloque de l'ARET (association pour la recherche en toxicologie), May 2018, Dijon, France
Communication dans un congrès hal-02785733v1

Drosophila melanogaster glutathione transferase overexpressed in the sensory organs after exposure to bitter molecules in food

Daniel Gonzalez , Stéphane Fraichard , Jean-François Ferveur , Yves Artur , Loïc Briand
The 26. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Marika Kapsimali, Sep 2016, Dijon, France. pp.E45-E46
Communication dans un congrès hal-02912249v1

Odorant-odorant metabolic competitions: ex vivo inhibition of the mammary pheromone catabolism

Aline Robert Hazotte , Gérard Coureaud , Hassan-Ismail Hanser , Rachel Schoumacker , Etienne E. Semon
26th Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), European Chemorecept Res Org, Sep 2016, Athènes, Greece. pp.E50-E51
Communication dans un congrès hal-01565748v1

New insights in vertebrate << biotransfolfaction >>

Jean-Marie Heydel , Aline Robert Hazotte , Rachel Schoumacker , Hassan-Ismail Hanser , Fabrice Neiers
26th Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), European Chemorecept Res Org, Sep 2016, Athènes, Greece
Communication dans un congrès hal-01565918v1

Aroma volatile odorous metabolites at olfactory mucosa level evidenced by in vitro and in vitro PTS-MS studies

Rachel Schoumacker , Aline Robert Hazotte , Etienne Semon , Elisabeth Guichard , Jean-Marie Heydel
26. annual meeting of the european-chemoreception-research-organization (ECRO), European Chemoreception Research Organization (ECRO). INT., Sep 2016, Dijon, France. ⟨10.1093/chemse/bjw120⟩
Communication dans un congrès hal-01595518v1

Aroma volatile metabolites at olfactory mucosa level evidenced by in vitro PTR-Tof-MS studies

Rachel Schoumacker , Aline Robert Hazotte , Etienne Sémon , Jean-Marie Heydel , Philippe Faure
7. International conference on proton transfer reaction mass spectrometry and its applications, Armin Hansel and Jürgen Dunkl, Feb 2016, Obergurgl, Austria
Communication dans un congrès hal-01515660v1

Real time monitoring of the metabolic capacity of ex-vivo rat olfactory mucosa by on-line PTR-MS

Rachel Schoumacker , Aline Robert Hazotte , Etienne Semon , Jean-Marie Heydel , Philippe Faure
11. Wartburg symposium on flavor chemistry & biology, Jun 2016, Eisenach, Germany
Communication dans un congrès hal-01581528v1

New insights in vertebrate 'biotransfolfaction'

Jean-Marie Heydel , Aline Robert Hazotte , Rachel Schoumacker , Hassan-Ismail Hanser , Fabrice Neiers
The 26. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2016, Dijon, France. pp.E-18-E19
Communication dans un congrès hal-02912358v1

Métabolisme périphérique des odorants : arrêt ou modulation du signal olfactif ?

Jean-Marie Heydel
1. réunion du GDR (Groupe De Réflexion) Odorant Odeur Olfaction, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2015, Dijon, France
Communication dans un congrès hal-01594081v1

Real time monitoring of the metabolic capacity of ex-vivo rat olfactory mucosa by on-line PTR-MS

Rachel Schoumacker , Aline Robert Hazotte , Jean-Marie Heydel , Philippe Faure , Etienne Semon
Congrès français de Spectrométrie de Masse et d'Analyse Protéomique (SMAP 2015), Sep 2015, Ajaccio, Corse, France. 1 p
Communication dans un congrès hal-01580721v1

Interactions of human nasal glutathione transferases with odorants.

Fabrice Neiers , Jean-Marie Heydel , Loïc Briand
25th Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), European Chemorecept Res Org, Sep 2015, Istanbul, Turkey. pp.422-422, ⟨10.1093/chemse/bjw019⟩
Communication dans un congrès hal-01398373v1

Caffeine metabolism in Drosophila melanogaster

Stéphane Fraichard , Alexandra Coelho , Philippe Faure , Jean-François Ferveur , Jean-Marie Heydel
24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), 2015, Oxford, United Kingdom
Communication dans un congrès hal-02741361v1

Role of CYP6d5 in the metabolism and the sensory perception of caffeine in Drosophila melanogaster

Alexandra Coelho , Stéphane Fraichard , Philippe Faure , Jean-François Ferveur , Jean-Marie Heydel
24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2014, Dijon, France
Communication dans un congrès hal-02742181v1

Oxidative stress and xenobiotic detoxification enzymes in rat astrocytes: Correlations with brain aging

Daniela Gradinaru , Anne-Laure Minn , Yves Artur , Jean-Marie Heydel
11th International Symposium on the Neurobiology and Neuroendocrinology of Aging, Jul 2012, Bregenz, Austria. pp.688-688, ⟨10.1016/j.exger.2013.05.021⟩
Communication dans un congrès hal-00879048v1

Role of xenobiotic metabolizing enzymes in the perception of caffeine in Drosophila melanogaster

Alexandra Coelho , Stéphane Fraichard , Philippe Faure , Jean-François Ferveur , Jean-Marie Heydel
16th International Symposium on Olfaction and Taste (ISOT), Jun 2012, Stockholm, Sweden
Communication dans un congrès hal-00746002v1

Role of CYTOCHROME p450 in the perception of caffeine in Drosophila melanogaster

Alexandra Coelho , Stéphane Fraichard , Philippe Faure , Jean-Marie Heydel
25th French Drosophila Conference, Oct 2011, Lyon, France
Communication dans un congrès hal-00745782v1

Role of CYTOCHROME p450 in the perception of caffeine in Drosophila melanogaster

Alexandra Coelho , Stéphane Fraichard , Philippe Faure , Jean-Marie Heydel
The 21st Congress of the Eropean Chemoreception Research Organisation (ECRO), Sep 2011, Manchester, United Kingdom. 1 p
Communication dans un congrès hal-00745790v1

Olfactory xenobiotic metabolizing enzymes have an impact on the stimulating properties of some odorants

Nicolas Thiebaud , Stéphanie Veloso da Silva , Ingrid Jakob , Gilles Sicard , Yves Artur
The 32nd Annual Meeting - Association for Chemoreception Sciences (AChemS), Apr 2010, St Pete Beach, Florida, United States
Communication dans un congrès hal-00816544v1

Biotransformation of odorants modifies the olfactory signal

Nicolas Thiebaud , Stéphanie Veloso da Silva , Ingrid Jakob , Gilles Gs Sicard , Yves Artur
31. Annual meeting - Association for chemoreception sciences (Achems), Apr 2009, Sarasota, Floride, United States. 1 p
Communication dans un congrès hal-02754927v1

Activity and expression of drug metabolizing enzymes in olfactory mucosa of rats treated by hepatic inducers

Nicolas Thiebaud , Maud M. Sigoillot , Joelle Chevallier , Yves Artur , Jean-Marie Heydel
List of Abstracts from the 18. Congress of European Chemoreception Research Organization, ECRO–2008, Sep 2008, Ljubljana, Slovenia
Communication dans un congrès hal-02822861v1

Glutathione conjugation of the rabbit mammary pheromone 2-methylbut-2-enal

Arièle Legendre , Hélène Tiesset , Ingrid Jacob , Anne-Marie Le Bon , Gérard Coureaud
18. Congress of European Chemoreception Research Organization, ECRO–2008, Sep 2008, Portoroz, Slovenia
Communication dans un congrès hal-02819467v1
Image document

Impact of aldehyde dehydrogenases and aldo-keto reductases on human olfactory peri-receptor events

Valentin Boichot , Franck Ménétrier , Jean-Michel Saliou , Frédéric Lirussi , Francis Canon
45. annual meeting - association for chemoreception sciences (AChemS), Apr 2023, Bonita Springs, Florida, United States.
Poster de conférence hal-04095217v1

[Thu-P1-027] Pheromone-induced odour learning and outstanding detection abilities in the newborn rabbit

Marie-Sabelle Hjeij , G. Coureaud , S. Garcia , Marc Thévenet , Jean-Marie Heydel
32. international congress of the european-chemoreception-research-organization (ECRO), Aug 2022, Berlin, Germany
Poster de conférence hal-03810680v1

The NAOMI (Nasal Odorant Metabolites) consortium: an international, multidisciplinary consortium investigating how metabolites resulting from nasal enzymatic odorant metabolism can shape odor perception

Jean-Marie Heydel , Thierry Thomas-Danguin , Jean-Luc Le Quéré , F. Neiers , Andrea Buettner
16. Weurman Flavour Research Symposium, May 2021, Dijon, France.
Poster de conférence hal-03253429v1

Characterization of rat glutathione transferases in olfactory mucus and epithelium

Jean-Marie Heydel , Franck Ménétrier , Christine Belloir , Philippe Faure , Evelyne Chavanne
29. Annual Meeting of the European-Chemoreception-Research-Organization, Sep 2019, Trieste, Italy. pp.P24, ECRO 2019
Poster de conférence hal-02885473v1

Odorant metabolism in olfactory mucus: characterization and impact on olfactory perception

Philippe Faure , Aline Robert-Hazotte , Fabrice Neiers , Franck Menetrier , Gérard Coureaud
40. annual meeting - association for chemoreception sciences (AChemS), Apr 2018, Bonita Springs, Florida, United States. Oxford University Press, Chemical Senses, 43 (7), 1 p., 2018
Poster de conférence hal-02735550v1

Odorants' metabolism in Human: a critical role in odor perception revealed

Aline Robert Hazotte , Thierry Thomas-Danguin , Théoline Fèvre , Catherine Potin , Jean-Marie Heydel
40. annual meeting - association for chemoreception sciences (AChemS), Apr 2018, Bonita Springs, Florida, United States. , Chemical Senses, 43 (7), 1 p., 2018
Poster de conférence hal-02736238v1

Structural and enzymatic characterization of a Drosophila melanogaster glutathione transferase overexpressed in the sensory organs after exposure to bitter molecules in food

Daniel Gonzalez , Stéphane Fraichard , Jean-François Ferveur , Yves Artur , Loïc Briand
17. international symposium on Olfaction and taste (ISOT), Jun 2016, Yokohama, Japan. Oxford University Press, Chemical Senses, 41 (9), 1 p., 2016, Chemical Senses
Poster de conférence hal-01579982v1

P45 - Drosophila melanogaster glutathione transferase overexpressed in the sensory organs after exposure to bitter molecules in food

Daniel Gonzalez , Stéphane Fraichard , Jean-François Ferveur , Yves Artur , Loïc Briand
The 26th Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2016, Dijon, France
Poster de conférence hal-02917669v1

Inhibition of the mammary pheromone catabolism by a second odorant present in the same mixture

Jean-Marie Heydel , Hassan-Ismail Hanser , Philippe Faure , Arièle Legendre , Benoist Schaal
24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2014, Dijon, France. Oxford University Press, Chemical Senses, 40 (3), pp.2, 2015, Proceedings of the 24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO)
Poster de conférence hal-02743312v1

Odorant biotransformation by human gluthatione-S-transferases

Quentin Dubant , Evelyne Chavanne , Christine Belloir , Jean-Marie Heydel , Yves Artur
24. Annual Meeting of the European Chemoreception Research Organization (ECRO 2014), Sep 2014, Dijon, France. Oxford University Press, Chemical Senses, 40 (3), pp.2, 2015, Abstracts from the 24th Annual Meeting of the European Chemoreception Research Organization (ECRO 2014). ⟨10.1093/chemse/bju073⟩
Poster de conférence hal-02744377v1

Rôle des enzymes du métabolisme des xénobiotiques dans la perception de la caféine chez la drosophile

Alexandra Coelho , Stéphane Fraichard , Philippe Faure , Jean-Marie Heydel
16. Colloque de Biologie de l’Insecte, Oct 2010, Lyon, France. 1 p., 2010
Poster de conférence hal-02822422v1

Olfactory xenobiotic metabolizing enzymes have an impact on the stimulating properties of some odorants

Nicolas Thiebaud , Stéphanie Veloso da Silva , Ingrid Jakob , Gilles Gs Sicard , Yves Artur
32. Annual meeting (AChemS), Apr 2010, Saint Petersburg, Florida, United States. 1 p., 2010
Poster de conférence hal-02818714v1

Major sulfation pathway for resveratrol metabolism in human hepatic derived cells and resveratrol –dependent inducibility of conjugating enzymes. Perspective in nutritional prevention

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel
2. congrès international Santé et Nutrition VITAGORA, Mar 2007, Dijon, France
Poster de conférence hal-03838598v1

Endocrine disruptors found in food modulate estradiol cellular metabolism

Nathalie Hanet , Allan Lançon , Jean-Marie Heydel , Dominique Delmas , Brigitte Jannin
2. congrès international Santé et Nutrition VITAGORA, Mar 2007, Dijon, France
Poster de conférence hal-03757959v1

Major sulfation pathway for resveratrol metabolism in human hepatic derived cells and resveratrol –dependent inducibility of conjugating enzymes. Perspective in nutritional prevention

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel
European Partnership Meetings: Taste, Nutrition, Health, Jun 2007, Dijon, France
Poster de conférence hal-03838370v1
Image document

Development of New Models of Oral Mucosa to Investigate the Impact of the Structure of Transmembrane Mucin-1 on the Mucosal Pellicle Formation and Its Physicochemical Properties

Clément Nivet , Irma Custovic , Laure Avoscan , Floris Bikker , Aline Bonnotte
Biomedicines, 2024, 12 (1), pp.139. ⟨10.3390/biomedicines12010139⟩
Article dans une revue hal-04395339v1

Rattus norvegicus Glutathione Transferase Omega 1 Localization in Oral Tissues and Interactions with Food Phytochemicals

Nicolas Poirier , Franck Ménétrier , Jade Moreno , Valentin Boichot , Jean-Marie Heydel
Journal of Agricultural and Food Chemistry, 2024, ⟨10.1021/acs.jafc.4c00483⟩
Article dans une revue hal-04493038v1
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Drosophila Free-Flight Odor Tracking is Altered in a Sex-Specific Manner By Preimaginal Sensory Exposure

Vincent Tolassy , Laurie Cazalé-Debat , Benjamin Houot , Rémy Reynaud , Jean-Marie Heydel
Journal of Chemical Ecology, 2023, 49 (3-4), pp.179-194. ⟨10.1007/s10886-023-01416-3⟩
Article dans une revue hal-04080541v1
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Characterization of human oxidoreductases involved in aldehyde odorant metabolism

Valentin Boichot , Franck Menetrier , Jean-Michel Saliou , Frederic Lirussi , Francis Canon
Scientific Reports, 2023, 13 (1), pp.4876. ⟨10.1038/s41598-023-31769-4⟩
Article dans une revue hal-04080823v1

Impact of aldehyde dehydrogenases and aldo-keto reductases in human olfactory peri-receptor events

Valentin Boichot , Franck Ménétrier , Jean Michel Saliou , Frédéric Lirussi , Francis Canon
Chemical Senses, 2023, 48, pp.bjad029.01
Article dans une revue hal-04473519v1

Unlocking Flavor Potential Using Microbial β-Glucosidases in Food Processing

Mariam Muradova , Alena Proskura , Francis Canon , Irina Aleksandrova , Mathieu Schwartz
Foods, 2023, 12 (24), pp.4484. ⟨10.3390/foods12244484⟩
Article dans une revue hal-04395322v1

Activity, Localization and Regulation of Odorant Metabolizing Enzymes in the Newborn Rabbit: New Highlights on the Mammary Pheromone Nasal Metabolism

Marie-Sabelle Hjeij , Franck Ménétrier , Stéphane Fraichard , Isabelle Chauvel , Gwenaelle Steyaert
Chemical Senses, 2023, 48, pp.bjad029.25
Article dans une revue hal-04473191v1
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Role of Insect and Mammal Glutathione Transferases in Chemoperception

Mathieu Schwartz , Valentin Boichot , Stéphane Fraichard , Mariam Muradova , Patrick Senet
Biomolecules, 2023, 13 (2), pp.322. ⟨10.3390/biom13020322⟩
Article dans une revue hal-04011738v1

Perspectives on Nasal Odorant Metabolism Research

Nicole Kornbausch , Jeanne Mérignac-Lacombe , F. Neiers , Thierry Thomas-Danguin , Jean-Marie Heydel
Journal of Agricultural and Food Chemistry, 2023, Special Issue, pp.Article ASAP. ⟨10.1021/acs.jafc.3c04662⟩
Article dans une revue hal-04272219v1

Role of human salivary enzymes in bitter taste perception

Mathieu Schwartz , Hélène Brignot , Gilles Feron , Thomas Hummel , Yunmeng Zhu
Food Chemistry, 2022, 386, pp.132798. ⟨10.1016/j.foodchem.2022.132798⟩
Article dans une revue hal-03712655v1

Nasal Odorant Competitive Metabolism Is Involved in the Human Olfactory Process

Aline Robert-Hazotte , Philippe Faure , Franck Ménétrier , Mireille Folia , Mathieu Schwartz
Journal of Agricultural and Food Chemistry, 2022, 70 (27), pp.8385-8394. ⟨10.1021/acs.jafc.2c02720⟩
Article dans une revue hal-03728119v1

The role of perireceptor events in flavor perception

Valentin Boichot , Mariam Muradova , Clément Nivet , Alena Proskura , Jean-Marie Heydel
Frontiers in Food Science and Technology, 2022, 2, pp.989291. ⟨10.3389/frfst.2022.989291⟩
Article dans une revue hal-03934249v1
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Odorant Metabolism in Humans

Nicole Kornbausch , Marcel Debong , Andrea Buettner , Jean-Marie Heydel , Helene Loos
Angewandte Chemie International Edition, 2022, 61 (35), pp.e202202866. ⟨10.1002/anie.202202866⟩
Article dans une revue hal-03744098v1

The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response

Fabrice Neiers , David D. Jarriault , Franck Menetrier , Loïc Briand , Jean-Marie Heydel
PLoS ONE, 2021, 16 (3), pp.e0249029. ⟨10.1371/journal.pone.0249029⟩
Article dans une revue hal-03191804v1
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Oral enzymatic detoxification system: Insights obtained from proteome analysis to understand its potential impact on aroma metabolization

Mathieu Schwartz , F. Neiers , Jean-Philippe Charles , Jean-Marie Heydel , Carolina Muñoz-González
Comprehensive Reviews in Food Science and Food Safety, 2021, 20 (6), pp.5516-5547. ⟨10.1111/1541-4337.12857⟩
Article dans une revue hal-03388853v1

Interactions between odorants and glutathione transferases in the human olfactory cleft

Mathieu Schwartz , Franck Menetrier , Jean-Marie Heydel , Evelyne Chavanne , Philippe Faure
Chemical Senses, 2020, 45 (8), pp.645-654. ⟨10.1093/chemse/bjaa055⟩
Article dans une revue hal-02917092v1
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Modulation of sex pheromone discrimination by a UDP-glycosyltransferase in Drosophila melanogaster

Stéphane Fraichard , Arièle Legendre , Philippe Lucas , Isabelle Chauvel , Philippe Faure
Genes, 2020, 11 (3), pp.237. ⟨10.3390/genes11030237⟩
Article dans une revue hal-02498984v1
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Publisher Correction: Nasal mucus glutathione transferase activity and impact on olfactory perception and neonatal behavior

Aline Robert Hazotte , Philippe Faure , Fabrice Neiers , Catherine Potin , Yves Artur
Scientific Reports, 2019, 9 (1), pp.8111. ⟨10.1038/s41598-019-44135-0⟩
Article dans une revue hal-02623163v1
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Ex vivo real-time monitoring of volatile metabolites resulting from nasal odorant metabolism

Aline Robert-Hazotte , Rachel Schoumacker , Etienne Semon , Loïc Briand , Elisabeth Guichard
Scientific Reports, 2019, 9 (1), pp.2492. ⟨10.1038/s41598-019-39404-x⟩
Article dans une revue hal-02621806v1
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Characterization of rat glutathione transferases in olfactory epithelium and mucus

Jean-Marie Heydel , Franck Menetrier , Christine Belloir , Francis Canon , Philippe Faure
PLoS ONE, 2019, 14 (7), pp.e0220259. ⟨10.1371/journal.pone.0220259⟩
Article dans une revue inserm-02264544v1
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Publisher Correction: Ex vivo real-time monitoring of volatile metabolites resulting from nasal odorant metabolism

Aline Robert-Hazotte , Rachel Schoumacker , Etienne Semon , Loïc Briand , Elisabeth Guichard
Scientific Reports, 2019, 9 (1), pp.8112. ⟨10.1038/s41598-019-44134-1⟩
Article dans une revue hal-02620777v1

Nasal odorant metabolism: enzymes, activity and function in olfaction

Jean-Marie Heydel , Philippe Faure , Fabrice Neiers
Drug Metabolism Reviews, 2019, 51 (2), pp.224-245. ⟨10.1080/03602532.2019.1632890⟩
Article dans une revue hal-02618624v1
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P-glycoprotein 1 affects chemoactivities of resveratrol against human colorectal cancer cells

Virginie Aires , Didier J. Colin , Agnès Doreau , Attilio Di Pietro , Jean-Marie Heydel
Nutrients, 2019, 11 (9), pp.2098. ⟨10.3390/nu11092098⟩
Article dans une revue hal-02627290v1
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Nasal mucus glutathione transferase activity and impact on olfactory perception and neonatal behavior

Aline Robert-Hazotte , Philippe Faure , Fabrice Neiers , Catherine Potin , Yves Artur
Scientific Reports, 2019, 9 (1), pp.3104. ⟨10.1038/s41598-019-39495-6⟩
Article dans une revue hal-02106638v1
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Data on the expression of GSTE1 and GSTE7 in Drosophila chemosensory organs after isothiocyanate exposure

Stéphane Fraichard , Daniel Gonzalez , Paul Grassein , Patrice Delarue , Patrick Senet
Data in Brief, 2018, 20, pp.254-257. ⟨10.1016/j.dib.2018.07.062⟩
Article dans une revue hal-02624391v1

Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification

Daniel Gonzalez , Stéphane Fraichard , Paul Grassein , Patrice Delarue , Patrick Senet
Insect Biochemistry and Molecular Biology, 2018, 95, pp.33-43. ⟨10.1016/j.ibmb.2018.03.004⟩
Article dans une revue hal-02383021v1
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Odorant-odorant metabolic interaction, a novel actor in olfactory perception and behavioral responsiveness

Hassan-Ismail Hanser , Philippe Faure , Aline Robert-Hazotte , Yves Artur , Patricia Duchamp-Viret
Scientific Reports, 2017, 7 (1), pp.10219. ⟨10.1038/s41598-017-10080-z⟩
Article dans une revue inserm-01599429v1

Real-time monitoring of the metabolic capacity of ex vivo rat olfactory mucosa by proton transfer reaction mass spectrometry (PTR-MS)

Rachel Schoumacker , Aline Robert-Hazotte , Jean-Marie Heydel , Philippe Faure , Jean-Luc Le Quéré
Analytical and Bioanalytical Chemistry, 2016, 408 (6), pp.1539 - 1543. ⟨10.1007/s00216-015-9289-7⟩
Article dans une revue hal-01399902v1

Odorant Metabolism Analysis by an Automated Ex Vivo Headspace Gas-Chromatography Method

Philippe Faure , Arièle Legendre , Hassan-Ismail Hanser , Isabelle Andriot , Yves Artur
Chemical Senses, 2016, 41 (1), pp.15 - 23. ⟨10.1093/chemse/bjv055⟩
Article dans une revue hal-01398990v1
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A self-inducible heterologous protein expression system in Escherichia coli

Loïc Briand , Guillaume Marcion , Alexandre Kriznik , Jean-Marie Heydel , Yves Artur
Scientific Reports, 2016, 6, pp.33037. ⟨10.1038/srep33037⟩
Article dans une revue hal-01392201v1
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Cytochrome P450-dependent metabolism of caffeine in [i]Drosophila melanogaster[/i]

Alexandra Coelho , Stéphane Fraichard , Gaëlle Le Goff , Philippe Faure , Yves Artur
PLoS ONE, 2015, 10 (2), ⟨10.1371/journal.pone.0117328⟩
Article dans une revue hal-01212004v1
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When the nose must remain responsive: glutathione conjugation of the mammary pheromone in the newborn rabbit

Arièle Legendre , Philippe Faure , Hélène Tiesset , Catherine Potin , Ingrid Jakob
Chemical Senses, 2014, 39 (5), pp.425 - 437. ⟨10.1093/chemse/bju013⟩
Article dans une revue hal-01222435v1
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Odorant metabolism catalyzed by olfactory mucosal enzymes influences peripheral olfactory responses in rats.

Nicolas Thiebaud , Stéphanie Veloso da Silva , Ingrid Jakob , Gilles Sicard , Joëlle Chevalier
PLoS ONE, 2013, 8 (3), pp.e59547. ⟨10.1371/journal.pone.0059547⟩
Article dans une revue hal-00818303v1

Odorant-binding proteins and xenobiotic metabolizing enzymes: implications in olfactory perireceptor events.

Jean-Marie Heydel , Alexandra Coelho , Nicolas Thiebaud , Arièle Legendre , Anne-Marie Le Bon
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 2013, 296 (9), pp.1333-45. ⟨10.1002/ar.22735⟩
Article dans une revue hal-00866526v1

Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes.

Daniela Gradinaru , Anne-Laure Minn , Yves Artur , Alain Minn , Jean-Marie Heydel
Toxicology Letters, 2012, 213 (3), pp.316-24. ⟨10.1016/j.toxlet.2012.07.014⟩
Article dans une revue hal-00767137v1

Ciprofibrate regulation of rat hepatic bilirubin glucuronidation and UDP-glucuronosyltransferases expression.

Jean-Marie Heydel , Philippe Garnier , Philippe Faure , Yves Artur
European journal of drug metabolism and pharmacokinetics, 2012, 37 (4), pp.233-40. ⟨10.1007/s13318-012-0091-z⟩
Article dans une revue hal-00767156v1
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Validation of a set of reference genes to study response to herbicide stress in grasses.

Cécile Petit , Fanny Pernin , Jean-Marie Heydel , Christophe Délye
BMC Research Notes, 2012, 5, pp.18. ⟨10.1186/1756-0500-5-18⟩
Article dans une revue hal-00782674v1

Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium.

Nicolas Thiebaud , Franck Ménétrier , Christine Belloir , Anne-Laure Minn , Fabrice Neiers
Neuroscience Letters, 2011, 505 (2), pp.180-5. ⟨10.1016/j.neulet.2011.10.018⟩
Article dans une revue hal-00755577v1

UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function.

Jean-Marie Heydel , Elzbieta J Holsztynska , Arièle Legendre , Nicolas Thiebaud , Yves Artur
Drug Metabolism Reviews, 2010, 42 (1), pp.74-97. ⟨10.3109/03602530903208363⟩
Article dans une revue hal-00745697v1

Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats.

Nicolas Thiebaud , Maud Sigoillot , Joëlle Chevalier , Yves Artur , Jean-Marie Heydel
Drug Metabolism and Disposition, 2010, 38 (10), pp.1865-75. ⟨10.1124/dmd.110.035014⟩
Article dans une revue hal-00745700v1

Drug metabolizing enzyme expression in rat choroid plexus: effects of in vivo xenobiotics treatment

Daniela Gradinaru , Anne-Laure Minn , Yves Artur , Alain Minn , Jean-Marie Heydel
Archives of Toxicology, 2009, 83 (6), pp.581-586. ⟨10.1007/s00204-008-0386-7⟩
Article dans une revue hal-02663406v1

Effects of endocrine disruptors on genes associated with 17 beta-estradiol metabolism and excretion

Nathalie Hanet , Allan Lancon , Dominique Delmas , Brigitte Jannin , Marie-Christine Chagnon
Steroids, 2008, 73 (12), pp.1242-1251. ⟨10.1016/j.steroids.2008.06.005⟩
Article dans une revue hal-02662141v1
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Effect of Retinoids on UDP-Glucuronosyltransferase 2B7 mRNA Expression in Caco-2 Cells

Yang Lu , Stacie Bratton , Jean-Marie Heydel , Anna Radominska-Panndya
Drug Metabolism and Pharmacokinetics, 2008, 23 (5), pp.364-372
Article dans une revue hal-02657038v1
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Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes.

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel
Drug Metabolism and Disposition, 2007, 35 (5), pp.699-703. ⟨10.1124/dmd.106.013664⟩
Article dans une revue hal-00259260v1

Induction of cytochrome P450 and/or detoxication enzymes by various extracts or rosemary: description of specific patterns

P. Debersac , Jean-Marie Heydel , Marie Josèphe Amiot , Hervé Goudonnet , Yves Artur
Food and Chemical Toxicology, 2001, 39 (9), pp.907-918
Article dans une revue hal-02682157v1

Odorant metabolizing enzymes in the peripheral olfactory process

Fabrice Neiers , Jeanne Mérignac-Lacombe , Jean-Marie Heydel
Elisabeth Guichard; Christian Salles. Flavor: From Food to Behaviors, Wellbeing and Health, Second edition, Chapter 5, , pp.127-147, 2023, 978-0-323-89903-1. ⟨10.1016/B978-0-323-89903-1.00014-1⟩
Chapitre d'ouvrage hal-04002413v1

Odorant metabolizing enzymes in the peripheral olfactory process

Jean-Marie Heydel , Hassan-Ismail Hanser , Philippe Faure , Fabrice Neiers
Flavour: From food to perception, John Wiley & Sons, Inc., 424 p., 2017, 978-1-118-92941-4
Chapitre d'ouvrage hal-01585726v1

Système olfacto-gustatif et toxicologie

Anne-Marie Le Bon , Jean-Marie Heydel , Fabrice Cheruel
Salesse, Roland ; Gervais, Rémi. Odorat et goût. De la neurobiologie des sens chimiques aux applications, Editions Quae, pp.465-472, 2012, Collection Synthèses, 978-2-7592-1770-0
Chapitre d'ouvrage hal-00787914v1

Périréception et protéines porteuses

Martine Maïbèche , Jean-Marie Heydel , Anne-Marie Le Bon , Jérôme Golebiowski , Loïc Briand
Salesse, Roland ; Gervais, Rémi. Odorat et goût. De la neurobiologie des sens chimiques aux applications, Editions Quae, pp.61-73, 2012, Collection Synthèses, 978-2-7592-1770-0
Chapitre d'ouvrage hal-00787942v1

Système olfacto-gustatif et toxicologie

Anne-Marie Le Bon , Jean-Marie Heydel , Fabrice Cheruel
Odorat et goût. De la neurobiologie des sens chimiques aux applications, Editions Quae, 2012, Synthèses (Quae), ISBN-13 : 978-2-7592-1770-0
Chapitre d'ouvrage hal-02804272v1

Périréception et protéines porteuses

Martine M. Maibeche Coisne , Jean-Marie Heydel , Anne-Marie Le Bon , Jérôme Golebiowski , Loïc Briand
Odorat et goût. De la neurobiologie des sens chimiques aux applications, Editions Quae, 2012, Synthèses (Quae), 978-2-7592-1770-0 978-2-7592-1770-0
Chapitre d'ouvrage hal-02809036v1