Access content directly

jean-philippe herbeuval

27
Documents
Researcher identifiers
  • IdHAL jean-philippe-herbeuval
  • ORCID 0000-0001-8114-8012
  • Google Scholar : https://scholar.google.com/citations?user=NB26Gi4AAAAJ&hl=fr
  • IdRef : 070408793

Presentation

2021 Nomination Commission Nationale 1-Fondation ARC: Immunologie-Onco-hématologie-Microbiologie 2020 Membre du Jury "année de recherche" pour les internes en médecine, Faculté de Médecine Paris-Saclay 2019 Promotion au grade DR1 commission 27 CNRS 2019 Fondateur Scientifique ERMIUM Therapeutics, Société par action simplifiées (SAS) 2019 Président du comité scientifique d’ERMIUM Therapeutics 2019 Expert scientifique, Deeptech Founders, BPI 2018 Formation à la création d’entreprise DeepTech Founders, Ministère de la Recherche, BPI France 2018 Direction de la plateforme de biologie moléculaire de la Faculté Biomédicale des Saints-Pères, Paris 2016 Direction de la plateforme cytométrie de flux Faculté Biomédicale des Saints-Pères Paris, Paris 2015 Création de la Fondation SantImmune hébergée par la Fondation Paris Descartes 2013 Membre du conseil scientifique du CICB, Paris 2013 Promotion au grade DR2, commission 27 CNRS 2012 Création de l’équipe CBMIT, CNRS UMR 8601, Université Paris Descartes 2008 Habilitation à Diriger des Recherches (HDR), Université Paris Descartes. 2006 Recrutement CR1, commission 24, CNRS UMR 8147, Hôpital Necker, Paris 2001 Postdoctorat, Fogarty fellowship, laboratoire du Dr. Gene Shearer EIB, NCI, NIH, Bethesda, USA, 2001 Doctorat d’Immunologie, GIMAP-INSERM Université Jean Monnet 1999 Monitorat à la Faculté des Sciences, Université Jean Monnet

Publications

Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection

Mirja Harms , Nikaïa Smith , Mingyu Han , Rüdiger Groß , Pascal von Maltitz
Science Advances , 2023, 9 (27), pp.eadf8251. ⟨10.1126/sciadv.adf8251⟩
Journal articles hal-04198762v1

CXCR4 as a novel target in immunology: moving away from typical antagonists

Birgit Caspar , Pietro Cocchiara , Armelle Melet , Kristof van Emelen , Annegret van der Aa
Future Drug Discovery, 2022, 4 (2), pp.FDD77. ⟨10.4155/fdd-2022-0007⟩
Journal articles hal-04198790v1
Image document

Differential levels of IFNα subtypes in autoimmunity and viral infection

Vincent Bondet , Mathieu P. Rodero , Céline Posseme , Pierre Bost , Jérémie Decalf
Cytokine, 2021, pp.155533. ⟨10.1016/j.cyto.2021.155533⟩
Journal articles pasteur-03236276v1
Image document

Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition

Simon Hayek , Nicolas Pietrancosta , Anna Hovhannisyan , Rodolphe Alves de Sousa , Nassima Bekaddour
European Journal of Medicinal Chemistry, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩
Journal articles hal-02372490v1
Image document

Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

Cyril Gitiaux , Vincent Bondet , Nassima Bekaddour , Patrick Nusbaum , Arnaud Hubas
Rheumatology, 2020, pp.kez508. ⟨10.1093/rheumatology/kez508⟩
Journal articles pasteur-02376263v1
Image document

Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine

Vincent Gies , Nassima Bekaddour , Yannick Dieudonné , Aurélien Guffroy , Quentin Frenger
Frontiers in Immunology, 2020, 11, ⟨10.3389/FIMMU.2020.01409⟩
Journal articles hal-02996379v1

Hitting the right spot on CXCR4

Jessica Mchugh , Jean-Philippe Herbeuval , Nikaia Smith
Nature Reviews Rheumatology, 2019, 15 (9), pp.514-514. ⟨10.1038/s41584-019-0287-6⟩
Journal articles hal-02372533v1
Image document

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

Ghizlane Maarifi , Nikaïa Smith , Sarah Maillet , Olivier Moncorgé , Célia Chamontin
Science Advances , 2019, 5 (11), pp.eaax3511. ⟨10.1126/sciadv.aax3511⟩
Journal articles hal-02404478v1
Image document

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment

Nikaïa Smith , Mathieu Rodéro , Nassima Bekaddour , Vincent Bondet , Yasser Ruiz-Blanco
Science Advances , 2019, 5 (7), pp.eaav9019. ⟨10.1126/sciadv.aav9019⟩
Journal articles pasteur-02282952v1

Pollution chimique et immunité innée antivirale : des liaisons dangereuses ?

Simon Hayek , Nicolas Pietrancosta , Rodolphe Alves De Sousa , Robert Barouki , Jean-Philippe Herbeuval
Virologie, 2018, 22 (1), pp.27-40. ⟨10.1684/vir.2018.0718⟩
Journal articles hal-03652525v1
Image document

Immature particles and capsid-free viral RNA produced by Yellow fever virus-infected cells stimulate plasmacytoid dendritic cells to secrete interferons

Laura Sinigaglia , Ségolène Gracias , Elodie Décembre , Matthieu Fritz , Daniela Bruni
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29235-7⟩
Journal articles hal-02327450v1

Chemical pollution and innate antiviral immunity: Dangerous Liaisons ?

Simon Hayek , Nicolas Pietrancosta , Rodolphe Alves De Sousa , Robert Barouki , Jean-Philippe Herbeuval
Virologie, 2018, 22 (1), pp.1-13. ⟨10.1684/vir.2018.0717⟩
Journal articles hal-02351261v1
Image document

Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay

Simon Hayek , Nassima Bekaddour , Laurie Besson , Rodolphe Alves de Sousa , Nicolas Pietrancosta
Slas Discovery, 2018, 24 (1), pp.25-37. ⟨10.1177/2472555218797078⟩
Journal articles hal-02324386v1
Image document

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Nikaïa Smith , Nicolas Pietrancosta , Sophia Davidson , Jacques Dutrieux , Lise Chauveau
Nature Communications, 2017, 8, pp.14253. ⟨10.1038/ncomms14253⟩
Journal articles hal-02075366v1

Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

Anas Allam , Laure Maigre , Julia Vergalli , Estelle Dumont , Bertrand Cinquin
Scientific Reports, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩
Journal articles hal-03652530v1
Image document

Identification of a small molecule that primes the type I interferon response to cytosolic DNA

Samira Khiar , Marianne Lucas-Hourani , Sebastien Nisole , Nikaia Smith , Olivier Helynck
Scientific Reports, 2017, 7 (1), pp.2561. ⟨10.1038/s41598-017-02776-z⟩
Journal articles pasteur-01570224v1

CXCR4, le nouveau régulateur de l’immunité innée ?

Nikaïa Smith , Nicolas Pietrancosta , Jean-Philippe Herbeuval
Médecine/Sciences, 2017, 33 (8-9), pp.711-713. ⟨10.1051/medsci/20173308008⟩
Journal articles hal-02351272v1
Image document

Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

Anas Allam , Laure Maigre , Julia Vergalli , Estelle Dumont , Bertrand Cinquin
Scientific Reports, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩
Journal articles hal-01831783v1

Plasmacytoid dendritic cells and myeloid cells differently contribute to BAFF over-expression during primary HIV infection

Gwenoline Borhis , Chantal Burelout , Nada Chaoul , Nikaïa Smith , Cecile Goujard
AIDS. Official journal of the international AIDS Society, 2016, pp.1. ⟨10.1097/QAD.0000000000000965⟩
Journal articles hal-02346130v1
Image document

An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF-7 pathway as a proof of concept

Nikaïa Smith , Pierre-Olivier Vidalain , Sébastien Nisole , Jean-Philippe Herbeuval
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep29891⟩
Journal articles hal-02438269v1

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.

Morgane Griesbeck , Susanne Ziegler , Sophie Laffont , Nikaïa Smith , Lise Chauveau
Journal of Immunology, 2015, 195 (11), pp.5327-36. ⟨10.4049/jimmunol.1501684⟩
Journal articles pasteur-01372393v1

Reduction of death receptor 5 expression and apoptosis of CD4+ T cells from HIV controllers

Lucie Barblu , Nikaïa Smith , Stéphanie Durand , Daniel Scott-Algara , Faroudy Boufassa
Clinical Immunology, 2014, 155 (1), pp.17-26. ⟨10.1016/j.clim.2014.07.010⟩
Journal articles hal-02322630v1

Rasv12 induces survivin/auroraB pathway conferring tumor cell apoptosis resistance

Réda Hadj-Slimane , Perayot Pamonsinlapatham , Jean-Philippe Herbeuval , Christiane Garbay , Yves Lepelletier
Cellular Signalling, 2010, 22 (8), pp.1214-1221. ⟨10.1016/j.cellsig.2010.03.013⟩
Journal articles hal-00473108v1

HIV-1 immunopathogenesis: How good interferon turns bad

Jean-Philippe Herbeuval , Gene Shearer
Clinical Immunology, 2007, 123 (2), pp.121-128. ⟨10.1016/j.clim.2006.09.016⟩
Journal articles hal-04204725v1

HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-α

Andrew Hardy , David Graham , Gene Shearer , Jean-Philippe Herbeuval
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (44), pp.17453-17458. ⟨10.1073/pnas.0707244104⟩
Journal articles hal-04204737v1

Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell Apoptosis

Jean-Philippe Herbeuval , Claude Lambert , Odile Sabido , Michèle Cottier , Pierre Fournel
JNCI: Journal of the National Cancer Institute, 2003, 95 (8), pp.611-621. ⟨10.1093/jnci/95.8.611⟩
Journal articles hal-04198816v1