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Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4
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Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3
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FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABA B Receptor
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation
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From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors
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RgIA4 potently blocks mouse $\alpha$9$\alpha$10 nAChRs and provides long lasting protection against oxaliplatin-induced cold allodynia
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Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation
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Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals
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Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges
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Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells
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Class C G protein-coupled receptors: reviving old couples with new partners
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Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
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Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
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OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity
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New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III
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Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling
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Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective
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Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors
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Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats
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Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer
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Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers
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Dynamics and modulation of metabotropic glutamate receptors
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Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
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Allosteric modulation of metabotropic glutamate receptors by chloride ions
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Editorial overview: Neurosciences: Targeting glutamatergic signaling in CNS diseases: new hopes?
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Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy
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Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format
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Article dans une revue
hal-01943335
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Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila.
Marianne Bjordal
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Julie Kniazeff
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Jean-Philippe Pin
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Article dans une revue
hal-00968719
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Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations
Oualid Sbai
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Article dans une revue
hal-01942940
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Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor
Chanjuan Xu
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Wenhua Zhang
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Philippe Rondard
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Jean-Philippe Pin
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Article dans une revue
hal-01942936
v1
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Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor
Xavier Rovira
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Ana Trapero
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Article dans une revue
istex
hal-01943327
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An allosteric modulator to control endogenous G protein-coupled receptors with light
S. Pittolo
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hal-01942934
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G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.
Sergi Ferré
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Article dans une revue
inserm-01067990
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The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and betaarrestin
Sylvain Armando
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Julie Quoyer
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Article dans une revue
hal-01950128
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Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor
Bruno Vilar
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Article dans une revue
hal-02448295
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Interaction of Protease-Activated Receptor 2 with G Proteins and beta-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer
Mohammed Akli Ayoub
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Article dans une revue
hal-01984750
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Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease
Marianne Amalric
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S. Lopez
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C. Goudet
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Article dans une revue
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hal-01384098
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Stability of GABA B receptor oligomers revealed by dual TR‐FRET and drug‐induced cell surface targeting
Laëtitia Comps‐agrar
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Julie Kniazeff
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Carsten Brock
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Eric Trinquet
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Article dans une revue
hal-03363950
v1
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Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.
Gérald Lemonnier
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Jean-Charles Quirion
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Jean-Philippe Pin
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Cyril Goudet
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Article dans une revue
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hal-00996602
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Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors
F. Fazio
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G. Molinaro
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Article dans une revue
hal-02448364
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Des dimères et des oligomères de récepteurs couplés aux protéines G, oui mais pourquoi ?
Julie Kniazeff
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Article dans une revue
hal-03363918
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Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2
Yong Geng
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Article dans une revue
hal-03363943
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A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.
Cyril Goudet
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Article dans une revue
hal-01182946
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G Protein Activation by Serotonin Type 4 Receptor Dimers: evidence that turning on two protomers is more efficient.
Lucie P. Pellissier
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Article dans une revue
hal-02482879
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A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects
Cyril Goudet
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Tiphanie Courtiol
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Current Neuropharmacology, 2011, 9 (1), pp.26
Article dans une revue
hal-01384798
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Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment
D. Cuomo
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E. Barabino
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Journal of Neurochemistry, 2009, 109, pp.1096-1105
Article dans une revue
hal-00409236
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IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
Anthony J. Harmar
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Article dans une revue
hal-02667062
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Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism
C. Beurrier
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FASEB Journal, 2009, 23, pp.3619-3628
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hal-00582954
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Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists
Isabelle A. Lemasson
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Abstracts of Papers of the American Chemical Society, 2009, 238
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hal-01384832
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A novel series of group III metabotropic glutamate receptor (mGluR) agonists
Francine C. Acher
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Abstracts of Papers of the American Chemical Society, 2009, 237
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hal-01384834
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Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells.
Jiri Kumpost
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inserm-00319023
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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
Yelin Chen
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Article dans une revue
inserm-00318958
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Modeling the binding and function of metabotropic glutamate receptors.
Xavier Rovira
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Juan Serra
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Julie Kniazeff
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Article dans une revue
hal-00319020
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Cell surface protein-protein interaction analysis with combined time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
Damien Maurel
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Carsten Brock
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Marie-Laure Rives
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Article dans une revue
hal-00318856
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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.
Philippe Rondard
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Carine Monnier
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Article dans une revue
hal-00318880
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Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.
Mohammed Akli Ayoub
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Damien Maurel
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Virginie Binet
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Article dans une revue
hal-00318930
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Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism.
Mélanie Frauli
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Nadia Hubert
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Stephan Schann
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Nicolas Triballeau
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Article dans une revue
inserm-00318866
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Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons.
Haijun Tu
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Chanjuan Xu
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Federica Bertaso
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Fangli Cao
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Article dans une revue
hal-00319022
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Activation of a Dimeric Metabotropic Glutamate Receptor by Inter-Subunit Rearrangement
Carsten Brock
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hal-00318871
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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Yelin Chen
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Cyril Goudet
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Kamondanai Hemstapat
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Tomas de Paulis
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Article dans une revue
inserm-00319012
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Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.
Virginie Binet
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Jennifer Lecaillon
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Claire Vol
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Julie Quoyer
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Article dans une revue
inserm-00318820
v1
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Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
Pauline Sibille
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Sébastien Lopez
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Isabelle Brabet
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Ornella Valenti
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Nadia Oueslati
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Article dans une revue
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inserm-00318976
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Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain
Cyril Goudet
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Eric Chapuy
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Abdelkrim Alloui
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Francine Acher
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Jean-Philippe Pin
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Article dans une revue
inserm-00318859
v1
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L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.
Chelliah Selvam
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Cyril Goudet
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Nadia Oueslati
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Jean-Philippe Pin
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Francine C. Acher
Article dans une revue
istex
inserm-00318965
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Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors.
Mélanie Frauli
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Pascal Neuville
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Claire Vol
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Jean-Philippe Pin
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Laurent Prézeau
Article dans une revue
inserm-00318879
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D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.
Eric Trinquet
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Hervé Bazin
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Florence Grillet
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Fabrice Maurin
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Article dans une revue
istex
inserm-00318996
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Asymmetry conformational changes in a GPCR dimer controlled by G-proteins
Marjorie Damian
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Aimée Martin
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Danielle Mesnier
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Jean-Philippe Pin
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Jean-Louis Banères
Article dans une revue
hal-00176784
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Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.
Christelle Masdeu
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Hélène Faure
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Josée Coulombe
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Angèle Schoenfelder
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André Mann
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Article dans une revue
istex
hal-00105551
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Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.
Veronika Hlavackova
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Cyril Goudet
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Julie Kniazeff
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Alice Zikova
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Damien Maurel
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Article dans une revue
inserm-00318934
v1
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Allosteric functioning of dimeric class C G-protein-coupled receptors.
Jean-Philippe Pin
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Jianfeng Liu
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Virginie Binet
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Cyril Goudet
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Article dans une revue
inserm-00094959
v1
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Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.
Cyril Goudet
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Julie Kniazeff
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Veronika Hlavackova
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Fanny Malhaire
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Damien Maurel
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Article dans une revue
inserm-00318925
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Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3.
Carsten Brock
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Laure Boudier
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Damien Maurel
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Jaroslav Blahos
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Jean-Philippe Pin
Article dans une revue
hal-00318967
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Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technology.
Damien Maurel
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Julie Kniazeff
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Gérard Mathis
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Eric Trinquet
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Jean-Philippe Pin
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Article dans une revue
hal-00318979
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Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.
Julie Kniazeff
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Pierre-Philippe Saintot
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Cyril Goudet
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Jianfeng Liu
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Annie Charnet
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Article dans une revue
hal-00319013
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Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.
Julie Kniazeff
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Damien Maurel
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Hervé Ansanay
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Laurent Prézeau
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Article dans une revue
hal-00318999
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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
Cyril Goudet
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Florence Gaven
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Julie Kniazeff
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Claire Vol
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Jianfeng Liu
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Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (1), pp.378-83. ⟨10.1073/pnas.0304699101⟩
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inserm-00319003
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Divergent Evolution in Metabotropic Glutamate Receptors
Christian Mitri
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Marie-Laure Parmentier
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Jean-Philippe Pin
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Joël Bockaert
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Yves Grau
Article dans une revue
hal-02506712
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The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor.
Virginie Binet
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Carole Brajon
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Laurent Le Corre
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Francine Acher
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Jean-Philippe Pin
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Article dans une revue
inserm-00318926
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Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.
Jianfeng Liu
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Damien Maurel
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Sébastien Etzol
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Isabelle Brabet
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Hervé Ansanay
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Article dans une revue
hal-00319008
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A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.
Béatrice Duthey
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Julie Perroy
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Bernhard Bettler
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Laurent Fagni
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Article dans une revue
inserm-00318936
v1
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A single olfactory receptor specifically binds a set of odorant molecules
Isabelle Gaillard
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Sylvie Rouquier
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Jean-Philippe Pin
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Patrice Mollard
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Sylvain Richard
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Article dans une revue
istex
hal-02948481
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Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons
Fabrice Ango
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J.C. Tu
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B. Xiao
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P.F. Worley
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Article dans une revue
istex
hal-00016884
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BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
Fiona Y. Carroll
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Andreas Stolle
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Philip M. Beart
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Arnd Voerste
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Isabelle Brabet
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Article dans une revue
inserm-00319007
v1
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Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.
Fabrice Ango
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Laurent Prézeau
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Thomas Muller
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Jian C. Tu
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Bo Xiao
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Article dans une revue
inserm-00318959
v1
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The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways
Julie Perroy
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G. J. Gutierrez
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V. Coulon
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Joël Bockaert
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Jean-Philippe Pin
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Article dans une revue
hal-02197463
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Aminobicyclo (2.2.1.)heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2
Frederique Tellier
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Francine Acher
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I. Brabet
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J.-P. Pin
Bioorganic and Medicinal Chemistry, 1998, 6, pp.195-208
Article dans une revue
hal-02691001
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Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists
Nathalie Todeschi
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Josyane Gharbi-Benarous
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Francine Acher
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Valery Laure
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Jean-Philippe Pin
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Article dans une revue
istex
hal-02356241
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Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids : new tools to discriminate between metabotropic glutamate receptor subtypes
Francine C. Acher
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Frédérique Tellier
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Laurent Fagni
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Journal of Medicinal Chemistry, 1997, 40, pp.3119-3129
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hal-02694452
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Synthesis of conformationally-constrained stereospecific analogs of glutamic acid as antagonists of metabotropic receptors
Frederique Tellier
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Francine Acher
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Bioorganic and Medicinal Chemistry Letters, 1995, 5 (22), pp.2627-2632
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hal-02705336
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Synthesis of conformationally-constrained analogs of glutamic acid as structural probes of glutamatergic receptors
Frederique Tellier
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Francine Acher
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I. Brabet
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J.-P. Pin
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Comptes rendus de l’Académie des sciences. Série 2, 1995, 321, pp.385-392
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hal-02705357
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