Jerome MOREAUX

131
Documents
Affiliations actuelles
  • Institut de génétique humaine (IGH)
  • CHU Montpellier = Montpellier University Hospital
  • Institut National de la Santé et de la Recherche Médicale (INSERM)
  • Institut universitaire de France (IUF)
Identifiants chercheurs

Publications

Publications

Targeting Transcription-Replication Conflicts using G-quadruplexes stabilizers in Multiple Myeloma

Laure Dutrieux , Sara Ovejero , Antoine Guillemin , Leriem Zellagui , Elke de Bruyne et al.
Blood Neoplasia, In press, pp.100072. ⟨10.1016/j.bneo.2025.100072⟩
Article dans une revue lirmm-04919719 v1
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PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

Marion Haas , Sabrina Cherfa , Léa Nguyen , Maxence Bourgoin , Gersende Caron et al.
Nature Communications, 2025, 16 (1), pp.256. ⟨10.1038/s41467-024-55572-5⟩
Article dans une revue hal-04883435 v1

KDM6A controls immunogenicity in MM

Jerome Moreaux
Blood, 2024, 144 (14), pp.1465-1467. ⟨10.1182/blood.2024026013⟩
Article dans une revue hal-04912732 v1

Quantitative Integrative Survival Prediction in Multiple Myeloma Patients Treated With Bortezomib-Based Induction, High-Dose Therapy and Autologous Stem Cell Transplantation

Manuela Hummel , Thomas Hielscher , Martina Emde-Rajaratnam , Hans Salwender , Susanne Beck et al.
JCO precision oncology, 2024, 8, ⟨10.1200/PO.23.00613⟩
Article dans une revue hal-04704595 v1
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BHLHE41, a transcriptional repressor involved in physiological processes and tumor development

Caroline Bret , Fabienne Desmots-Loyer , Jérôme Moreaux , Thierry Fest
Cellular Oncology, 2024, Online ahead of print. ⟨10.1007/s13402-024-00973-3⟩
Article dans une revue hal-04704590 v1
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Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation

Elina Alaterre , Sara Ovejero , Caroline Bret , Laure Dutrieux , Dassou Sika et al.
Blood, 2024, 144 (5), pp.496-509. ⟨10.1182/blood.2023023237⟩
Article dans une revue hal-04701434 v1

A case of refractory IgG4-related disease successfully treated with daratumumab and lenalidomide

Denis Coulomb , Vanessa Lacheretz-Szablewski , Nicolas Robert , Anne-Marie Dupuy , Rayane Berrahouane et al.
Rheumatology, 2024, 64 (2), pp.895-897. ⟨10.1093/rheumatology/keae448⟩
Article dans une revue hal-04704591 v1
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Transient loss of Polycomb components induces an epigenetic cancer fate

Victoria Parreno , Vincent Loubiere , Bernd Schuettengruber , Lauriane Fritsch , Chetan C. Rawal et al.
Nature, 2024, 629 (8012), pp.688-696. ⟨10.1038/s41586-024-07328-w⟩
Article dans une revue hal-04581411 v1
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FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population

Michaël Constantinides , Nicolas Robert , Caroline Multrier , Loïs Coënon , Mauricio Campos-Mora et al.
OncoImmunology, 2024, 13 (1), pp.2388306. ⟨10.1080/2162402X.2024.2388306⟩
Article dans une revue hal-04704594 v1
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Single-hit genome editing optimized for maturation in B cells redirects their specificity toward tumor antigens

Natsuko Ueda , Marine Cahen , Jenny Leonard , Laurent Deleurme , Stéphane Dreano et al.
Scientific Reports, 2024, 14 (1), pp.22432. ⟨10.1038/s41598-024-74005-3⟩
Article dans une revue hal-04723581 v1

CD38 , CD39 , and BCL2 differentiate disseminated forms of high‐grade B‐cell lymphomas in biological fluids from Burkitt lymphoma and diffuse large B‐cell lymphoma

Pauline Marianini , Vanessa Lacheretz-Szablewski , Marion Almeras , Jérôme Moreaux , Caroline Bret
Cytometry Part B: Clinical Cytometry, 2024, 144 (5), pp.496-509. ⟨10.1002/cyto.b.22208⟩
Article dans une revue hal-04704587 v1
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MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling

Hervé Técher , Diyavarshini Gopaul , Jonathan Heuzé , Nail Bouzalmad , Baptiste Leray et al.
Nature Communications, 2024, 15 (1), pp.5423. ⟨10.1038/s41467-024-49740-w⟩
Article dans une revue hal-04748159 v1

Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma

Angélique Bruyer , Laure Dutrieux , Hugues de Boussac , Thibaut Martin , Djamila Chemlal et al.
Frontiers in Oncology, 2023, 13, ⟨10.3389/fonc.2023.1271847⟩
Article dans une revue hal-04704603 v1

3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness

L. Baert , B. Manfroi , M. Quintero , O. Chavarria , P.V. Barbon et al.
Matrix Biology, 2023, 120, pp.60-75. ⟨10.1016/j.matbio.2023.05.005⟩
Article dans une revue hal-04444452 v1
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Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data

Mohammad Salma , Elina Alaterre , Jérôme Moreaux , Eric Soler
Epigenetics & Chromatin, 2023, 16 (1), pp.23. ⟨10.1186/s13072-023-00497-4⟩
Article dans une revue hal-04705018 v1
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Extreme thrombocytosis with an aggressive evolution harboring a novel variant of calreticulin (CALR) in exon 3

Sarah Bonnet , Serge Carillo , Baptiste Legrand , Barbara Burroni , Thierry Lavabre-Bertrand et al.
European Journal of Haematology, 2023, 112 (3), pp.475-478. ⟨10.1111/ejh.14126⟩
Article dans une revue hal-04550049 v1

Immunophenotypic portrait of leukemia‐associated‐phenotype markers in B acute lymphoblastic leukemia

Emilia Boris , Alexandre Theron , Valentin Montagnon , Nicolas Rouquier , Marion Almeras et al.
Cytometry Part B: Clinical Cytometry, 2023, 106 (1), pp.45-57. ⟨10.1002/cyto.b.22153⟩
Article dans une revue hal-04704605 v1
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EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma

Djamila Chemlal , Emmanuel Varlet , Amelie Machura , Sara Ovejero , Guilhem Requirand et al.
Leukemia, 2023, 37 (9), pp.1925-1928. ⟨10.1038/s41375-023-01983-0⟩
Article dans une revue hal-04252294 v1

The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance

Sara Ovejero , Elena Viziteu , Laure Dutrieux , Julie Devin , Yea-Lih Lin et al.
Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.983181⟩
Article dans une revue hal-04705022 v1
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Comprehensive characterization of the epigenetic landscape in Multiple Myeloma

Elina Alaterre , Sara Ovejero , Laurie Herviou , Hugues de Boussac , Giorgio Papadopoulos et al.
Theranostics, 2022, 12 (4), pp.1715-1729. ⟨10.7150/thno.54453⟩
Article dans une revue hal-03810219 v1

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma

Julie Devin , Tatiana Cañeque , Yea-Lih Lin , Lucie Mondoulet , Jean-Luc Veyrune et al.
Cancer Research, 2022, 82 (6), pp.998-1012. ⟨10.1158/0008-5472.CAN-21-0218⟩
Article dans une revue hal-04053839 v1
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miRNA profile at diagnosis predicts treatment outcome in patients with B-chronic lymphocytic leukemia: A FILO study

Isabelle Duroux-Richard , Anne-Laure Gagez , Elina Alaterre , Rémi Letestu , Olfa Khalifa et al.
Frontiers in Immunology, 2022, 13, pp.983771. ⟨10.3389/fimmu.2022.983771⟩
Article dans une revue hal-03946290 v1

LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological Neoplasms

François van Laethem , Lucie Donaty , Emmanuelle Tchernonog , Vanessa Lacheretz-Szablewski , Jennifer Russello et al.
International Journal of Molecular Sciences, 2022, 23 (24), pp.16136. ⟨10.3390/ijms232416136⟩
Article dans une revue hal-04705024 v1
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LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological Neoplasms

François van Laethem , Lucie Donaty , Emmanuelle Tchernonog , Vanessa Lacheretz-Szablewski , Jennifer Russello et al.
International Journal of Molecular Sciences, 2022, 23 (24), pp.16136. ⟨10.3390/ijms232416136⟩
Article dans une revue hal-03980144 v1
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PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma

Marion Haas , Gersende Caron , Fabrice Chatonnet , Stéphane Manenti , Elina Alaterre et al.
Blood, 2022, 139 (15), pp.2316-2337. ⟨10.1182/blood.2021014011⟩
Article dans une revue hal-04822853 v2

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma

Julie Devin , Tatiana Cañeque , Yea-Lih Lin , Lucie Mondoulet , Jean-Luc Veyrune et al.
Cancer Research, 2022, 82 (6), pp.998-1012. ⟨10.1158/0008-5472.CAN-21-0218⟩
Article dans une revue hal-04706505 v1
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The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias

Rosa Paolillo , Mathias Boulanger , Pierre Gâtel , Ludovic Gabellier , Marion de Toledo et al.
Haematologica, 2022, 107 (11), pp.2562-2575. ⟨10.3324/haematol.2021.279889⟩
Article dans une revue hal-03759821 v2
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Targeting the β 2 ‐adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism

Hatice Satilmis , Emma Verheye , Philip Vlummens , Inge Oudaert , Niels Vandewalle et al.
Journal of Pathology, 2022, 259 (1), pp.69-80. ⟨10.1002/path.6020⟩
Article dans une revue hal-04590992 v1

Comprehensive characterization of the epigenetic landscape in Multiple Myeloma

Elina Alaterre , Sara Ovejero , Laurie Herviou , Hugues de Boussac , Giorgio Papadopoulos et al.
Theranostics, 2022, 12 (4), pp.1715-1729. ⟨10.7150/thno.54453⟩
Article dans une revue hal-04705568 v1

Angiogenic factors could help us to define patients obtaining complete response with undetectable minimal residual disease in untreated CLL patients treated by FCR: results from the CLL2010FMP, a FILO study

Anne Laure Gagez , Franciane Paul , Elina Alaterre , Valérie Gouilleux-Gruart , Edouard Tuaillon et al.
Leukemia & lymphoma, 2021, 62 (13), pp.3160-3169. ⟨10.1080/10428194.2021.1955879⟩
Article dans une revue hal-03640354 v1
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G9a/GLP targeting in MM promotes autophagy-associated apoptosis and boosts proteasome inhibitor–mediated cell death

Eva de Smedt , Julie Devin , Catharina Muylaert , Nicolas Robert , Guilhem Requirand et al.
Blood Advances, 2021, 5 (9), pp.2325-2338. ⟨10.1182/bloodadvances.2020003217⟩
Article dans une revue hal-03243723 v1
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The microenvironment of DLBCL is characterized by noncanonical macrophages recruited by tumor-derived CCL5

Benoît Manfroi , Maria de Grandis , Jérôme Moreaux , Sébastien Tabruyn , Jean-François Mayol et al.
Blood Advances, 2021, 5 (21), pp.4338-4351. ⟨10.1182/bloodadvances.2021004203⟩
Article dans une revue hal-04444537 v1
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Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types

Maksim Erokhin , Olga Chetverina , Balázs Győrffy , Victor Tatarskiy , Vladic Mogila et al.
Cancers, 2021, 13 (13), pp.3155. ⟨10.3390/cancers13133155⟩
Article dans une revue hal-03693300 v1
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RNA-Sequencing-Based Transcriptomic Score with Prognostic and Theranostic Values in Multiple Myeloma

Elina Alaterre , Veronika Vikova , Alboukadel Kassambara , Angélique Bruyer , Nicolas Robert et al.
Journal of Personalized Medicine, 2021, 11 (10), pp.988. ⟨10.3390/jpm11100988⟩
Article dans une revue hal-03639307 v1
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Discovery of candidate DNA methylation cancer driver genes

Heng Pan , Loic Renaud , Ronan Chaligne , Johannes Bloehdorn , Eugen Tausch et al.
Cancer Discovery, 2021, pp.candisc.1334.2020. ⟨10.1158/2159-8290.CD-20-1334⟩
Article dans une revue hal-03243749 v1
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Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Laurie Herviou , Sara Ovejero , Fanny Izard , Ouissem Karmous-Gadacha , Claire Gourzones et al.
Clinical Epigenetics, 2021, 13 (1), ⟨10.1186/s13148-021-01160-z⟩
Article dans une revue hal-03450559 v1

Angiogenic factors could help us to define patients obtaining complete response with undetectable minimal residual disease in untreated CLL patients treated by FCR: results from the CLL2010FMP, a FILO study

Anne Laure Gagez , Franciane Paul , Elina Alaterre , Valérie Gouilleux-Gruart , Edouard Tuaillon et al.
Leukemia & lymphoma, 2021, 62 (13), pp.3160-3169. ⟨10.1080/10428194.2021.1955879⟩
Article dans une revue hal-04041296 v1
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The origin of pre-plasmablastic cells

Jerome Moreaux
Blood, 2021, 137 (9), pp.1134-1135. ⟨10.1182/blood.2020009746⟩
Article dans une revue hal-03243758 v1

Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Laurie Herviou , Sara Ovejero , Fanny Izard , Ouissem Karmous-Gadacha , Claire Gourzones et al.
Clinical Epigenetics, 2021, 13 (1), pp.174. ⟨10.1186/s13148-021-01160-z⟩
Article dans une revue hal-04707906 v1

The microenvironment of DLBCL is characterized by noncanonical macrophages recruited by tumor-derived CCL5

Benoît Manfroi , Maria de Grandis , Jérôme Moreaux , Sébastien Tabruyn , Jean-François Mayol et al.
Blood Advances, 2021, 5 (21), pp.4338-4351. ⟨10.1182/bloodadvances.2021004203⟩
Article dans une revue hal-03531067 v1

RNA-Sequencing-Based Transcriptomic Score with Prognostic and Theranostic Values in Multiple Myeloma

Elina Alaterre , Veronika Vikova , Alboukadel Kassambara , Angélique Bruyer , Nicolas Robert et al.
Journal of Personalized Medicine, 2021, 11 (10), pp.988. ⟨10.3390/jpm11100988⟩
Article dans une revue hal-04707897 v1
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Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

Laure Dutrieux , Yea-Lih Lin , Malik Lutzmann , Raphaël Rodriguez , Michel Cogné et al.
Cancers, 2021, 13 (15), pp.3755. ⟨10.3390/cancers13153755⟩
Article dans une revue (article de synthèse) hal-04707941 v1
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RNA Sequencing Data-driven Dissection of Human Plasma Cell Differentiation Reveals New Potential Transcription Regulators

Alboukadel Kassambara , Laurie Herviou , Sara Ovejero , Michel Jourdan , Coraline Thibaut et al.
Leukemia, 2021, 35 (5), pp.1451-1462. ⟨10.1038/s41375-021-01234-0⟩
Article dans une revue hal-03243729 v1
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Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

Laure Dutrieux , Yea-Lih Lin , Malik Lutzmann , Raphaël Rodriguez , Michel Cogné et al.
Cancers, 2021, 13 (15), pp.3755. ⟨10.3390/cancers13153755⟩
Article dans une revue hal-03365519 v1

The microenvironment of DLBCL is characterized by noncanonical macrophages recruited by tumor-derived CCL5

Benoît Manfroi , Maria de Grandis , Jérôme Moreaux , Sébastien Tabruyn , Jean-François Mayol et al.
Blood Advances, 2021, 5 (21), pp.4338-4351. ⟨10.1182/bloodadvances.2021004203⟩
Article dans une revue hal-04707920 v1
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Immunotherapy perspectives in the new era of B-cell editing

Natsuko Ueda , Marine Cahen , Yannic Danger , Jérôme Moreaux , Christophe Sirac et al.
Blood Advances, 2021, 5 (6), pp.1770-1779. ⟨10.1182/bloodadvances.2020003792⟩
Article dans une revue hal-03202338 v1

Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

Laure Dutrieux , Yea-Lih Lin , Malik Lutzmann , Raphaël Rodriguez , Michel Cogné et al.
Cancers, 2021, 13 (15), pp.3755. ⟨10.3390/cancers13153755⟩
Article dans une revue hal-04094386 v1
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Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites

J. Basbous , Antoine Aze , Laurent Chaloin , Rana Lebdy , Dana Hodroj et al.
Nucleic Acids Research, 2020, 48 (4), pp.1886-1904. ⟨10.1093/nar/gkz1162⟩
Article dans une revue hal-02556387 v1
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Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features

Orianne Villard , Mathieu Armanet , Guilhem Couderc , Claire Bony , Jerome Moreaux et al.
Stem Cell Research and Therapy, 2020, 11, pp.158. ⟨10.1186/s13287-020-01649-z⟩
Article dans une revue hal-02961501 v1
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DNA Repair Expression Profiling to Identify High-Risk Cytogenetically Normal Acute Myeloid Leukemia and Define New Therapeutic Targets

Ludovic Gabellier , Caroline Bret , Guillaume Bossis , Guillaume Cartron , Jérôme Moreaux
Cancers, 2020, 12 (10), pp.2874. ⟨10.3390/cancers12102874⟩
Article dans une revue hal-03014671 v1
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A Retrospective Comparison of DLI and gDLI for Post-Transplant Treatment

Sylvain Lamure , Franciane Paul , Anne-Laure Gagez , Jérémy Delage , Laure Vincent et al.
Journal of Clinical Medicine, 2020, 9 (7), pp.2204. ⟨10.3390/jcm9072204⟩
Article dans une revue hal-03203259 v1
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Kinome expression profiling to target new therapeutic avenues in multiple myeloma

Hugues de Boussac , Angelique Bruyer , Michel Jourdan , Anke Maes , Nicolas N. Robert et al.
Haematologica, 2020, 105 (3), pp.784-795. ⟨10.3324/haematol.2018.208306⟩
Article dans une revue hal-02587620 v1
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The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation

Fabrice Chatonnet , Amandine Pignarre , Aurelien Serandour , Gersende Caron , Stéphane Avner et al.
Haematologica, 2020, 105 (3), pp.774-783. ⟨10.3324/haematol.2019.222133⟩
Article dans une revue hal-02165596 v1
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Role of Polycomb Complexes in Normal and Malignant Plasma Cells

Emmanuel Varlet , Sara Ovejero , Anne-Marie Martinez , Giacomo Cavalli , Jerome Moreaux
International Journal of Molecular Sciences, 2020, 21 (21), pp.8047. ⟨10.3390/ijms21218047⟩
Article dans une revue hal-03243763 v1
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Phenotypic Characterization of Diffuse Large B-Cell Lymphoma Cells and Prognostic Impact

Julie Devin , Alboukadel Kassambara , Angelique Bruyer , Jérôme Moreaux , Caroline Bret
Journal of Clinical Medicine, 2019, 8 (7), pp.1074. ⟨10.3390/jcm8071074⟩
Article dans une revue hal-02571739 v1

Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related ( ATR ) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer

Eve Combès , Augusto Andrade , Diego Tosi , Henri-Alexandre Michaud , Flavie Coquel et al.
Cancer Research, 2019, 79 (11), pp.2933-2946. ⟨10.1158/0008-5472.CAN-18-2807⟩
Article dans une revue hal-02361669 v1
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EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation

Laurie Herviou , Michel Jourdan , Anne-Marie Martinez , Giacomo Cavalli , Jerome Moreaux
Leukemia, 2019, 33 (8), pp.2047-2060. ⟨10.1038/s41375-019-0392-1⟩
Article dans une revue hal-03243777 v1
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Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells

Claire Gourzones , Céline Bellanger , Sylvain Lamure , Ouissem Karmous Gadacha , Elvira Garcia de Paco et al.
Cancers, 2019, 11 (4), pp.439. ⟨10.3390/cancers11040439⟩
Article dans une revue hal-02870153 v1
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Maternal embryonic leucine zipper kinase is a novel target for diffuse large B cell lymphoma and mantle cell lymphoma

Anke Maes , Ken Maes , Philip Vlummens , Hendrik de Raeve , Julie Devin et al.
Blood Cancer Journal, 2019, 9 (12), ⟨10.1038/s41408-019-0249-x⟩
Article dans une revue hal-02542010 v1
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Prospective target assessment and multimodal prediction of survival for personalized and risk-adapted treatment strategies in multiple myeloma in the GMMG-MM5 multicenter trial

Dirk Hose , Susanne Beck , Hans Salwender , Martina Emde , Uta Bertsch et al.
Journal of Hematology and Oncology, 2019, 12, pp.65. ⟨10.1186/s13045-019-0750-5⟩
Article dans une revue hal-03243769 v1
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Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Julien Bianco , Valérie Bergoglio , Yea-Lih Lin , Marie-Jeanne Pillaire , Anne-Lyne Schmitz et al.
Nature Communications, 2019, 10 (1), pp.910. ⟨10.1038/s41467-019-08886-8⟩
Article dans une revue hal-02047561 v1
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Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistance

Veronika Vikova , Michel Jourdan , Nicolas Robert , Guilhem Requirand , Stephanie Boireau et al.
Theranostics, 2019, 9 (2), pp.540-553. ⟨10.7150/thno.28374⟩
Article dans une revue hal-02883457 v1
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Treatment May Be Harmful: Mechanisms/Prediction/Prevention of Drug-Induced DNA Damage and Repair in Multiple Myeloma

Claire Gourzones , Caroline Bret , Jérôme Moreaux
Frontiers in Genetics, 2019, 10, pp.861. ⟨10.3389/fgene.2019.00861⟩
Article dans une revue hal-02552817 v1

Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway

Kim de Veirman , Eline Menu , Ken Maes , Nathan de Beule , Eva de Smedt et al.
Cancer Letters, 2019, 442, pp.233-241. ⟨10.1016/j.canlet.2018.11.002⟩
Article dans une revue hal-01980419 v1
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Anticorps anti-CD38 dans le myélome multiple

Jérôme Moreaux
Médecine/Sciences, 2019, 35 (12), pp.1001-1004. ⟨10.1051/medsci/2019198⟩
Article dans une revue hal-03243767 v1
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The Anaphase-Promoting Complex/Cyclosome: A New Promising Target in Diffuse Large B-cell Lymphoma and Mantle Cell Lymphoma

Anke Maes , Ken Maes , Hendrik de Raeve , Eva de Smedt , Philip Vlummens et al.
British Journal of Cancer, 2019, 120 (12), pp.1137--1146. ⟨10.1038/s41416-019-0471-0⟩
Article dans une revue hal-02862214 v1
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Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

Laurie Herviou , Fanny Izard , Ouissem Karmous-Gadacha , Claire Gourzones , Celine Bellanger et al.
BioRxiv, In press, ⟨10.1101/776930⟩
Article dans une revue hal-02355848 v1

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

Mohamad Omar Ashi , Nivine Srour , Jean-Marie Lambert , Anne Marchalot , Ophélie Martin et al.
Cellular and molecular immunology, 2018, ⟨10.1038/s41423-018-0160-6⟩
Article dans une revue hal-02048156 v1

[EZH2 is therapeutic target for personalized treatment in multiple myeloma].

Laurie Herviou , Giacomo Cavalli , Jérôme Moreaux
Bulletin du Cancer, 2018, 105 (9), pp.804 - 819. ⟨10.1016/j.bulcan.2018.06.003⟩
Article dans une revue hal-01904689 v1
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An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy

Vanessa Szablewski , Caroline Bret , Alboukadel Kassambara , Julie Devin , Guillaume Cartron et al.
Oncotarget, 2018, 9 (27), pp.19079--19099. ⟨10.18632/oncotarget.24901⟩
Article dans une revue hal-02345949 v1

Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression

Eva de Smedt , Ken Maes , Stefaan Verhulst , Hui Lui , Alboukadel Kassambara et al.
Cancer Research, 2018, 78 (5), pp.1155 - 1168. ⟨10.1158/0008-5472.CAN-17-1544⟩
Article dans une revue hal-01864144 v1
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PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs

Laurie Herviou , Alboukadel Kassambara , Stéphanie Boireau , Nicolas Robert , Guilhem Requirand et al.
Clinical Epigenetics, 2018, 10, pp.121. ⟨10.1186/s13148-018-0554-4⟩
Article dans une revue hal-02315111 v1
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DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells

Angelique Bruyer , Ken Maes , Laurie Herviou , Alboukadel Kassambara , Anja Seckinger et al.
British Journal of Cancer, 2018, 118 (8), pp.1062 - 1073. ⟨10.1038/s41416-018-0025-x⟩
Article dans une revue hal-01792246 v1

BrdU incorporation in multiparameter flow cytometry: A new cell cycle assessment approach in multiple myeloma

Guilhem Requirand , Nicolas Robert , Stéphanie Boireau , Laure Vincent , Anja Seckinger et al.
Cytometry Part B: Clinical Cytometry, 2018, ⟨10.1002/cyto.b.21730⟩
Article dans une revue hal-02048196 v1
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Characterization of human FCRL4-positive B cells

Michel Jourdan , Nicolas Robert , Maïlys Cren , Coraline Thibaut , Christophe Duperray et al.
PLoS ONE, 2017, 12 (6), pp.e0179793. ⟨10.1371/journal.pone.0179793⟩
Article dans une revue hal-01560458 v1

Automated and simplified identification of normal and abnormal plasma cells in Multiple Myeloma by flow cytometry

Elina Alaterre , Sébastien Raimbault , Jean-Michel Garcia , Thierry Rème , Guilhem Requirand et al.
Cytometry Part B: Clinical Cytometry, 2017, ⟨10.1002/cyto.b.21590⟩
Article dans une revue hal-01680330 v1
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Differential effects of lenalidomide during plasma cell differentiation

Michel Jourdan , Maïlys Cren , Peter A Schäfer , Nicolas Robert , Christophe Duperray et al.
Oncotarget, 2016, 7 (19), pp.28096-28111. ⟨10.18632/oncotarget.8581⟩
Article dans une revue hal-01355076 v1
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EZH2 in normal hematopoiesis and hematological malignancies

Laurie Herviou , Giacomo Cavalli , Guillaume Cartron , Bernard Klein , Jérôme Moreaux
Oncotarget, 2016, 7 (3), pp.2284-2296. ⟨10.18632/oncotarget.6198⟩
Article dans une revue hal-01275235 v1
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Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma

Elena Viziteu , Camille Grandmougin , Harmut Goldschmidt , Anja Seckinger , Dirk Hose et al.
British Journal of Cancer, 2016, 114 (5), pp.519-523. ⟨10.1038/bjc.2016.20⟩
Article dans une revue hal-01284314 v1
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Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells

S Lub , A Maes , K Maes , K de Veirman , E de Bruyne et al.
Oncotarget, 2016, 7 (4), pp.4061-4076. ⟨10.18632/oncotarget.6768⟩
Article dans une revue hal-01299387 v1
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RECQ helicases are deregulated in hematological malignancies in association with a prognostic value

Elena Viziteu , Alboukadel Kassambara , Philippe Pasero , Bernard Klein , Jerome Moreaux
Biomarker Research, 2016, 4, pp.3. ⟨10.1186/s40364-016-0057-4⟩
Article dans une revue inserm-01322505 v1
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Drug metabolism and clearance system in tumor cells of patients with multiple myeloma

Wafa Hassen , Alboukadel Kassambara , Thierry Rème , S Sahota , A Seckinger et al.
Oncotarget, 2015, 6 (8), pp.6431-6447. ⟨10.18632/oncotarget.3237⟩
Article dans une revue hal-01153138 v1
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Factors influencing extramedullary relapse after allogeneic transplantation for multiple myeloma

L. Vincent , P. Ceballos , Carine Plassot , J. C. Méniane , P. Quittet et al.
Blood Cancer Journal, 2015, 5 (8), pp.e341-e341. ⟨10.1038/bcj.2015.48⟩
Article dans une revue hal-01955536 v1
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miRNAs in multiple myeloma - a survival relevant complex regulator of gene expression

A Seckinger , T Meissner , Jérôme Moreaux , V. Benes , J Hillengass et al.
Oncotarget, 2015, 6 (36), pp.39165-39183. ⟨10.18632/oncotarget.5381⟩
Article dans une revue hal-01237028 v1
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Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia

Marion Lapierre , Audrey Castet-Nicolas , Delphine Gitenay , Stéphan Jalaguier , Catherine Teyssier et al.
Journal of Hematology and Oncology, 2015, 8 (1), pp.20. ⟨10.1186/s13045-015-0116-6⟩
Article dans une revue hal-01153157 v1
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The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells

Niels Weinhold , Tobias Meissner , David Johnson , Anja Seckinger , Jerome Moreaux et al.
Haematologica, 2015, 100 (3), pp.e110-e113. ⟨10.3324/haematol.2014.118786⟩
Article dans une revue hal-02157564 v1

DNA repair in diffuse large B-cell lymphoma: a molecular portrait

Caroline Bret , Bernard Klein , Guillaume Cartron , Jean-François Schved , Angelos Constantinou et al.
British Journal of Haematology, 2015, 169 (2), pp.296-299. ⟨10.1111/bjh.13206⟩
Article dans une revue hal-01143993 v1
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Identification of a 20-gene expression-based risk score as a predictor of clinical outcome in chronic lymphocytic leukemia patients.

Elias Bou Samra , Bernard Klein , Thérèse Commes , Jérôme Moreaux
BioMed Research International , 2014, 2014, pp.423174. ⟨10.1155/2014/423174⟩
Article dans une revue inserm-01023921 v1
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A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy

Alboukadel Kassambara , Claire Gourzones , S. Sahota , Thierry Rème , Jérôme Moreaux et al.
Oncotarget, 2014, 5 (9), pp.2487-2498. ⟨10.18632/oncotarget.1740⟩
Article dans une revue hal-01006634 v1
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DNA methylation score is predictive of myeloma cell sensitivity to 5-azacitidine.

Jérôme Moreaux , Angelique Bruyer , Jean-Luc Veyrune , Hartmut Goldschmidt , Dirk Hose et al.
British Journal of Haematology, 2014, 164 (4), pp.613-6. ⟨10.1111/bjh.12660⟩
Article dans une revue inserm-00906054 v1
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Nucleotide excision DNA repair pathway as a therapeutic target in patients with high-risk diffuse large B cell lymphoma.

Caroline Bret , Bernard Klein , Jérôme Moreaux
Cell Cycle, 2013, 12 (12), pp.1811-2. ⟨10.4161/cc.25115⟩
Article dans une revue inserm-00840265 v1
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Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells.

Alboukadel Kassambara , Matthieu Schoenhals , Jérôme Moreaux , Jean-Luc Veyrune , Thierry Rème et al.
PLoS ONE, 2013, 8 (4), pp.e62752. ⟨10.1371/journal.pone.0062752⟩
Article dans une revue inserm-00840268 v1
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Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors.

Jérôme Moreaux , Thierry Rème , Wim Leonard , Jean-Luc Veyrune , Guilhem Requirand et al.
British Journal of Cancer, 2013, 109 (3), pp.676-85. ⟨10.1038/bjc.2013.392⟩
Article dans une revue inserm-00906782 v1
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New prognostic markers, determined using gene expression analyses, reveal two distinct subtypes of chronic myelomonocytic leukaemia patients.

Elias Bou Samra , Jérôme Moreaux , Fabienne Vacheret , Ken Mills , Florence Rufflé et al.
British Journal of Haematology, 2012, 157 (3), pp.347-56. ⟨10.1111/j.1365-2141.2012.09069.x⟩
Article dans une revue inserm-00681007 v1
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Clinical and prognostic role of annexin A2 in multiple myeloma.

Anja Seckinger , Tobias Meiβner , Jérôme Moreaux , Daniela Depeweg , Jens Hillengass et al.
Blood, 2012, 120 (5), pp.1087-94. ⟨10.1182/blood-2012-03-415588⟩
Article dans une revue inserm-00726994 v1
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Residual malignant and normal plasma cells shortly after high dose melphalan and stem cell transplantation. Highlight of a putative therapeutic window in Multiple Myeloma?

Anouk Caraux , Laure Vincent , Salahedine Bouhya , Philippe Quittet , Jérôme Moreaux et al.
Oncotarget, 2012, 3 (11), pp.1335-47
Article dans une revue inserm-00802665 v1
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Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.

Elias Bou Samra , Bernard Klein , Thérèse Commes , Jérôme Moreaux
Oncotarget, 2012, 3 (8), pp.824-32
Article dans une revue inserm-00726665 v1
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Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma.

Alboukadel Kassambara , Dirk Hose , Jérôme Moreaux , Brian A. Walker , Alexei Protopopov et al.
Haematologica, 2012, 97 (4), pp.622-30. ⟨10.3324/haematol.2011.046821⟩
Article dans une revue inserm-00727008 v1
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Identification of pluripotent and adult stem cell genes unrelated to cell cycle and associated with poor prognosis in multiple myeloma.

Alboukadel Kassambara , Dirk Hose , Jérôme Moreaux , Thierry Rème , Jennifer Torrent et al.
PLoS ONE, 2012, 7 (7), pp.e42161. ⟨10.1371/journal.pone.0042161⟩
Article dans une revue inserm-00802686 v1
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Gene expression-based risk score in diffuse large B-cell lymphoma.

Caroline Bret , Bernard Klein , Jérôme Moreaux
Oncotarget, 2012, 3 (12), pp.1700-10
Article dans une revue inserm-00802570 v1
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STEAP1 is overexpressed in cancers: A promising therapeutic target.

Jérôme Moreaux , Alboukadel Kassambara , Dirk Hose , Bernard Klein
Biochemical and Biophysical Research Communications, 2012, epub ahead of print. ⟨10.1016/j.bbrc.2012.10.123⟩
Article dans une revue inserm-00760262 v1
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Development of gene expression-based score to predict sensitivity of multiple myeloma cells to DNA methylation inhibitors.

Jérôme Moreaux , Thierry Rème , Wim Leonard , Jean-Luc Veyrune , Guilhem Requirand et al.
Molecular Cancer Therapeutics, 2012, 11 (12), pp.2685-92. ⟨10.1158/1535-7163.MCT-12-0721⟩
Article dans une revue inserm-00760269 v1
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SULFs in human neoplasia: implication as progression and prognosis factors.

Caroline Bret , Jérôme Moreaux , Jean-François Schved , Dirk Hose , Bernard Klein
Journal of Translational Medicine, 2011, 9 (1), pp.72. ⟨10.1186/1479-5876-9-72⟩
Article dans une revue inserm-00601153 v1
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Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration.

Jérôme Moreaux , Dirk Hose , Alboukadel Kassambara , Thierry Rème , Philippe Moine et al.
Blood, 2011, 117 (4), pp.1280-90. ⟨10.1182/blood-2010-04-279760⟩
Article dans une revue inserm-00906774 v1
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A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.

Jérôme Moreaux , Bernard Klein , Régis Bataille , Géraldine Descamps , Sophie Maïga et al.
Haematologica, 2011, 96 (4), pp.574-82. ⟨10.3324/haematol.2010.033456⟩
Article dans une revue inserm-00550232 v1
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MYEOV is a prognostic factor in multiple myeloma.

Jérôme Moreaux , Dirk Hose , Amélie Bonnefond , Thierry Rème , Nicolas Robert et al.
Experimental Hematology, 2010, 38 (12), pp.1189-1198.e3. ⟨10.1016/j.exphem.2010.09.002⟩
Article dans une revue inserm-00906769 v1
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Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays.

Karène Mahtouk , Jérôme Moreaux , Dirk Hose , Thierry Rème , Tobias Meissner et al.
BMC Cancer, 2010, 10 (1), pp.198. ⟨10.1186/1471-2407-10-198⟩
Article dans une revue inserm-00668220 v1
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Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis.

Anja Seckinger , Tobias Meissner , Jérôme Moreaux , Hartmut Goldschmidt , Gwenny M. Fuhler et al.
Oncogene, 2009, 28 (44), pp.3866-79. ⟨10.1038/onc.2009.257⟩
Article dans une revue inserm-00437705 v1
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The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor.

Anne Catherine Sprynski , Dirk Hose , Laurent Caillot , Thierry Rème , John D. Shaughnessy Jr et al.
Blood, 2009, 113 (19), pp.4614-4626. ⟨10.1182/blood-2008-07-170464⟩
Article dans une revue inserm-00367812 v1
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Inhibition of Aurora-kinases for tailored risk adapted treatment of multiple myeloma.

Dirk Hose , Thierry Rème , Tobias Meissner , Jérôme Moreaux , Anja Seckinger et al.
Blood, 2009, 113 (18), pp.4331-4340. ⟨10.1182/blood-2008-09-178350⟩
Article dans une revue inserm-00368414 v1
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APRIL is overexpressed in cancer: link with tumor progression.

Jérôme Moreaux , Jean-Luc Veyrune , John de Vos , Bernard Klein
BMC Cancer, 2009, 9 (1), pp.83. ⟨10.1186/1471-2407-9-83⟩
Article dans une revue inserm-00369505 v1
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Induction of angiogenesis by normal and malignant plasma cells.

Dirk Hose , Jérôme Moreaux , Tobias Meissner , Anja Seckinger , Hartmut Goldschmidt et al.
Blood, 2009, 114, pp.128-143. ⟨10.1182/blood-2008-10-184226⟩
Article dans une revue inserm-00401390 v1
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Embryonic stem cell markers expression in cancers.

Matthieu Schoenhals , Alboukadel Kassambara , John De Vos , Dirk Hose , Jérôme Moreaux et al.
Biochemical and Biophysical Research Communications, 2009, 383, pp.157-162. ⟨10.1016/j.bbrc.2009.02.156⟩
Article dans une revue inserm-00367054 v1
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APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop.

Jérôme Moreaux , Anne-Catherine Sprynski , Stacey R. Dillon , Karène Mahtouk , Michel Jourdan et al.
European Journal of Haematology, 2009, 83 (2), pp.119-29. ⟨10.1111/j.1600-0609.2009.01262.x⟩
Article dans une revue inserm-00397249 v1
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CD200: a putative therapeutic target in cancer.

Jérôme Moreaux , Jean-Luc Veyrune , Thierry Rème , John de Vos , Bernard Klein
Biochemical and Biophysical Research Communications, 2008, 366 (1), pp.117-22. ⟨10.1016/j.bbrc.2007.11.103⟩
Article dans une revue inserm-00195258 v1
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MMSET is overexpressed in cancers: Link with tumor aggressiveness.

Alboukadel Kassambara , Bernard Klein , Jérôme Moreaux
Biochemical and Biophysical Research Communications, 2008, 379, pp.840-845. ⟨10.1016/j.bbrc.2008.12.093⟩
Article dans une revue inserm-00356253 v1
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Targeting NF-kappaB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth.

Michel Jourdan , Jérôme Moreaux , John De Vos , Dirk Hose , Karène Mahtouk et al.
British Journal of Haematology, 2007, 138 (2), pp.160-8. ⟨10.1111/j.1365-2141.2007.06629.x⟩
Article dans une revue inserm-00160647 v1
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Input of DNA microarrays to identify novel mechanisms in multiple myeloma biology and therapeutic applications.

Karène Mahtouk , Dirk Hose , John de Vos , Jérôme Moreaux , Michel Jourdan et al.
Clinical Cancer Research, 2007, 13 (24), pp.7289-95. ⟨10.1158/1078-0432.CCR-07-1758⟩
Article dans une revue inserm-00270566 v1
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TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines.

Jérôme Moreaux , Dirk Hose , Michel Jourdan , Thierry Rème , Michael Hundemer et al.
Haematologica, 2007, 92 (6), pp.803-11
Article dans une revue inserm-00162002 v1
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Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma.

Karène Mahtouk , Friedrich W. Cremer , Thierry Rème , Michel Jourdan , Marion Baudard et al.
Oncogene, 2006, 25 (54), pp.7180-91. ⟨10.1038/sj.onc.1209699⟩
Article dans une revue inserm-00128880 v1
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Microarray-based understanding of normal and malignant plasma cells.

John de Vos , Dirk Hose , Thierry Rème , Karin Tarte , Jérôme Moreaux et al.
Immunological Reviews, 2006, 210, pp.86-104. ⟨10.1111/j.0105-2896.2006.00362.x⟩
Article dans une revue inserm-00149827 v1
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CD200 is a new prognostic factor in multiple myeloma.

Jérôme Moreaux , Dirk Hose , Thierry Rème , Eric Jourdan , Michael Hundemer et al.
Blood, 2006, 108 (13), pp.4194-7. ⟨10.1182/blood-2006-06-029355⟩
Article dans une revue inserm-00130595 v1
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Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells.

Karène Mahtouk , Dirk Hose , Thierry Rème , John de Vos , Michel Jourdan et al.
Oncogene, 2005, 24 (21), pp.3512-24. ⟨10.1038/sj.onc.1208536⟩
Article dans une revue inserm-00130206 v1
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The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.

Jérôme Moreaux , Friedrich W. Cremer , Thierry Rème , Marc Raab , Karene Mahtouk et al.
Blood, 2005, 106 (3), pp.1021-30. ⟨10.1182/blood-2004-11-4512⟩
Article dans une revue inserm-00129406 v1
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BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.

Jérôme Moreaux , Eric Legouffe , Eric Jourdan , Philippe Quittet , Thierry Rème et al.
Blood, 2004, 103 (8), pp.3148-57. ⟨10.1182/blood-2003-06-1984⟩
Article dans une revue inserm-00129502 v1
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Survival and proliferation factors of normal and malignant plasma cells.

Bernard Klein , Karin Tarte , Michel Jourdan , Karene Mathouk , Jérôme Moreaux et al.
International Journal of Hematology, 2003, 78 (2), pp.106-13
Article dans une revue inserm-00130900 v1

Integrative Single-Cell RNA-Seq and Single-Cell ATAC-Seq Analysis of Human Plasma Cell Differentiation

Elina Alaterre , Sara Ovejero , Marion Espéli , Thierry Fest , Michel Cogné et al.
65th Annual Meeting of the American-Society-of-Hematology (ASH), Dec 2023, San Diego, United States. ⟨10.1182/blood-2023-181507⟩
Communication dans un congrès hal-04513440 v1