Juan Reguera

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Documents
Affiliation actuelle
  • Architecture et fonction des macromolécules biologiques (AFMB)
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Publications

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Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options

Mikael Feracci , Sergio Hernandez , Laura Garlatti , Clemence Mondielli , Renaud Vincentelli et al.
International Union of Crystallography journal, 2024, 11 (3), pp.374-383. ⟨10.1107/S205225252400304X⟩
Article dans une revue hal-04746756 v1
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Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture

Vasiliya Kril , Michael Hons , Celine Amadori , Claire Zimberger , Laurine Couture et al.
Nature Communications, 2024, 15, pp.8106. ⟨10.1038/s41467-024-51952-z⟩
Article dans une revue hal-04717331 v1
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Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration

Phong Quoc Nguyen , Sonia Huecas , Amna Asif-Laidin , Adrián Plaza-Pegueroles , Beatrice Capuzzi et al.
Nature Communications, 2023, 14 (1), pp.1729. ⟨10.1038/s41467-023-37109-4⟩
Article dans une revue hal-04056067 v1
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Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

Rhian Jones , Michael Hons , Nadia Rabah , Noelia Zamarreño , Rocío Arranz et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (12), ⟨10.1073/pnas.2213934120⟩
Article dans une revue hal-04129138 v1
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Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication

Quentin Durieux Trouilleton , Sergio Barata-García , Benoît Arragain , Juan Reguera , Hélène Malet
Nature Communications, 2023, 14 (1), pp.2954. ⟨10.1038/s41467-023-38555-w⟩
Article dans une revue hal-04129164 v1
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Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity $in\ vitro$

Phong Quoc Nguyen , Christine Conesa , Elise Rabut , Gabriel Bragagnolo , Célia Gouzerh et al.
Journal of Biological Chemistry, 2021, 297 (4), pp.101093. ⟨10.1016/j.jbc.2021.101093⟩
Article dans une revue hal-03402697 v1
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Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors

Kristina Kovacikova , Marina Gorostiola González , Rhian Jones , Juan Reguera , Alba Gigante et al.
Antimicrobial Agents and Chemotherapy, 2021, 65 (7), ⟨10.1128/AAC.02566-20⟩
Article dans une revue hal-03366195 v1
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Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

Benoît Arragain , Grégory Effantin , Piotr Gerlach , Juan Reguera , Guy Schoehn et al.
Nature Communications, 2020, 11 (1), pp.3590. ⟨10.1038/s41467-020-17349-4⟩
Article dans une revue hal-02907948 v1

Capping pores of alphavirus nsP1 gate membranous viral replication factories

Rhian Jones , Gabriel Bragagnolo , Rocío Arranz , Juan Reguera
Nature, 2020, 589 (7843), pp.615 - 619. ⟨10.1038/s41586-020-3036-8⟩
Article dans une revue hal-03139499 v1
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Structure and function of the Toscana virus cap-snatching endonuclease

Rhian Jones , Sana Lessoued , Kristina Meier , Stéphanie Devignot , Sergio Barata-García et al.
Nucleic Acids Research, 2019, 47, pp.10914-10930. ⟨10.1093/nar/gkz838⟩
Article dans une revue hal-02611184 v1
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High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

Benoît Arragain , Juan Reguera , Ambroise Desfosses , Irina Gutsche , Guy Schoehn et al.
Article dans une revue hal-01987302 v1

Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

Francois Ferron , Friedemann Weber , Juan de La Torre , Juan Reguera
Virus Research, 2017, 234, pp.118 - 134. ⟨10.1016/j.virusres.2017.01.018⟩
Article dans une revue hal-01802833 v1
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Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection

C Santiago , G Mudgal , J Reguera , R Recacha , Sebastien Albrecht et al.
Scientific Reports, 2017, 7, pp.46045. ⟨10.1038/srep46045⟩
Article dans une revue hal-02154721 v1
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Structural insights into reptarenavirus cap-snatching machinery

Maria Rosenthal , Nadja Gogrefe , Dominik Vogel , Juan Reguera , Bianka Rauschenberger et al.
PLoS Pathogens, 2017, 13 (5), pp.e1006400. ⟨10.1371/journal.ppat.1006400⟩
Article dans une revue hal-05251346 v1
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Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein

Yaiza Fernández-García , Juan Reguera , Carola Busch , Gregor Witte , Oliberto Sánchez-Ramos et al.
PLoS Pathogens, 2016, 12 (6), pp.e1005635. ⟨10.1371/journal.ppat.1005635⟩
Article dans une revue hal-05251225 v1
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Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases

Juan Reguera , Piotr Gerlach , Maria Rosenthal , Stephanie Gaudon , Francesca Coscia et al.
PLoS Pathogens, 2016, 12 (6), pp.e1005636. ⟨10.1371/journal.ppat.1005636⟩
Article dans une revue hal-05251270 v1

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases

Juan Reguera , Piotr Gerlach , Stephen Cusack
Current Opinion in Structural Biology, 2016, 36, pp.75-84. ⟨10.1016/j.sbi.2016.01.002⟩
Article dans une revue hal-05251380 v1

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

Juan Reguera , Gaurav Mudgal , César Santiago , José Casasnovas
Cell, 2015, 161 (6), pp.1267-1279. ⟨10.1016/j.cell.2015.05.006⟩
Article dans une revue hal-01993602 v1

Segmented negative strand RNA virus nucleoprotein structure

Juan Reguera , Stephen Cusack , Daniel Kolakofsky
Current Opinion in Virology, 2014, 5, pp.7-15. ⟨10.1016/j.coviro.2014.01.003⟩
Article dans une revue istex hal-05251312 v1
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Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein

Juan Reguera , Hélène Malet , Friedemann Weber , Stephen Cusack
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110, pp.7246 - 7251. ⟨10.1073/pnas.1302298110⟩
Article dans une revue hal-05251335 v1
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Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

Juan Reguera , César Santiago , Gaurav Mudgal , Desiderio Ordoño , Luis Enjuanes et al.
PLoS Pathogens, 2012, 8 (8), pp.e1002859. ⟨10.1371/journal.ppat.1002859⟩
Article dans une revue hal-05251322 v1

Antigenic modules in the N-terminal S1 region of the transmissible gastroenteritis virus spike protein

Juan Reguera , Desiderio Ordoño , César Santiago , Luis Enjuanes , José Casasnovas
Journal of General Virology, 2011, 92 (5), pp.1117-1126. ⟨10.1099/vir.0.027607-0⟩
Article dans une revue hal-05251215 v1
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Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

Juan Reguera , Friedemann Weber , Stephen Cusack
PLoS Pathogens, 2010, 6 (9), pp.e1001101. ⟨10.1371/journal.ppat.1001101⟩
Article dans une revue hal-05251262 v1

Nuclear Transport of Trimeric Assembly Intermediates Exerts a Morphogenetic Control on the Icosahedral Parvovirus Capsid

Laura Riolobos , Juan Reguera , Mauricio Mateu , José Almendral
Journal of Molecular Biology, 2006, 357 (3), pp.1026-1038. ⟨10.1016/j.jmb.2006.01.019⟩
Article dans une revue istex hal-05251298 v1
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Functional Relevance of Amino Acid Residues Involved in Interactions with Ordered Nucleic Acid in a Spherical Virus

Juan Reguera , Esther Grueso , Aura Carreira , Cristina Sánchez-Martínez , José M Almendral et al.
Journal of Biological Chemistry, 2005, 280 (18), pp.17969 - 17977. ⟨10.1074/jbc.m500867200⟩
Article dans une revue hal-05251278 v1
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Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid

Juan Reguera , Aura Carreira , Laura Riolobos , José María Almendral , Mauricio Mateu
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (9), pp.2724-2729. ⟨10.1073/pnas.0307748101⟩
Article dans une revue hal-05251305 v1
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In Vitro Disassembly of a Parvovirus Capsid and Effect on Capsid Stability of Heterologous Peptide Insertions in Surface Loops

Aura Carreira , Margarita Menéndez , Juan Reguera , José María Almendral , Mauricio G Mateu
Journal of Biological Chemistry, 2003, 279 (8), pp.6517 - 6525. ⟨10.1074/jbc.m307662200⟩
Article dans une revue hal-05251291 v1