Julien Vignard

Chargé de Recherche Classe Normale dans l'équipe "Génotoxicité et Signalisation" de l'UMR 1331 Toxalim, INRAE
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Publications

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Molecular Dynamics and Quantum Chemical Insights into the Molecular Basis of Differential Toxicity of the Mycotoxin Deoxynivalenol (DON) and Its Microbial Derivatives DOM-1 and 3-epi-DON

Kanhaya Lal , Julien Vignard , Gladys Mirey , Franck Jolibois , Isabelle P Oswald et al.

ACS Omega, 2026, 11 (6), pp.9575-9586. ⟨10.1021/acsomega.5c09756⟩

Article dans une revue hal-05495502v1
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Comparison of different techniques for γH2AX/pH3 biomarkers quantification for chemical genotoxicity assessment

Cynthia Recoules , Chloé Huertas , Julien Vignard , Marc Audebert

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2025, 906, pp.503878. ⟨10.1016/j.mrgentox.2025.503878⟩

Article dans une revue hal-05514863v1
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Genotoxic interaction between deoxynivalenol and acrylamide

Chloé Huertas , Aboubacar B Coulibaly , Delphine Payros , Marie Penary , Sylvie Puel et al.

Food Research International, 2025, 214, pp.116633. ⟨10.1016/j.foodres.2025.116633⟩

Article dans une revue hal-05076454v1
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More than a mutagenic Aflatoxin B1 precursor: The multiple cellular targets of Versicolorin A revealed by global gene expression analysis

Carine Al-Ayoubi , Ophélie Rocher , Claire Naylies , Yannick Lippi , Julien Vignard et al.

Environmental Pollution, 2024, 363, pp.125138. ⟨10.1016/j.envpol.2024.125138⟩

Article dans une revue hal-04835843v1
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Mutagenicity and genotoxicity assessment of the emerging mycotoxin Versicolorin A, an Aflatoxin B1 precursor

Carine Al-Ayoubi , Maria Alonso-Jauregui , Amaya Azqueta , Julien Vignard , Gladys Mirey et al.

Environmental Pollution, 2023, 335, pp.122276. ⟨10.1016/j.envpol.2023.122276⟩

Article dans une revue hal-04202803v1
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Dairy By-Products and Lactoferrin Exert Antioxidant and Antigenotoxic Activity on Intestinal and Hepatic Cells

Inés Abad , Julien Vignard , Catherine Bouchenot , Dimitra Graikini , Laura Grasa et al.

Foods, 2023, 12 (10), pp.2073. ⟨10.3390/foods12102073⟩

Article dans une revue hal-04112315v1
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Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium

Julien Vignard , Aurelie Pettes-Duler , Eric Gaultier , Christel Cartier , Laurent Weingarten et al.

Nanotoxicology, 2023, 17 (4), pp.289-309. ⟨10.1080/17435390.2023.2210664⟩

Article dans une revue hal-04104748v1
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Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response

Benoît J Pons , Aurélie Pettes-Duler , Claire Naylies , Frédéric Taieb , Catherine Bouchenot et al.

Cellular and Molecular Life Sciences, 2021, 78 (17-18), pp.6319-6335. ⟨10.1007/s00018-021-03902-x⟩

Article dans une revue hal-03306242v1
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Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products

Kevin Gillois , Charlotte Stoffels , Mathilde Lévêque , Isabelle Fourquaux , Justine Blesson et al.

Science of the Total Environment, 2021, 754, ⟨10.1016/j.scitotenv.2020.142324⟩

Article dans une revue hal-02945727v1
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Cytolethal Distending Toxin Promotes Replicative Stress Leading to Genetic Instability Transmitted to Daughter Cells

William Tremblay , Florence Mompart , Elisa Lopez , Muriel Quaranta , Valérie Bergoglio et al.

Frontiers in Cell and Developmental Biology, 2021, 9, pp.1-15. ⟨10.3389/fcell.2021.656795⟩

Article dans une revue hal-03248449v1
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Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B

Benoît Pons , Nicolas Loiseau , Saleha Hashim , Souria Tadrist , Gladys Mirey et al.

Toxins, 2020, 12 (9), pp.530. ⟨10.3390/toxins12090530⟩

Article dans une revue hal-02927138v1
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Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells

Thierry Gauthier , Carolina Duarte-Hospital , Julien Vignard , Elisa Boutet-Robinet , Michael Sulyok et al.

Environment International, 2020, 137, 15 p. ⟨10.1016/j.envint.2020.105568⟩

Article dans une revue hal-02556860v1
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Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells

Anne Fernandez-Vidal , Liana C. Arnaud , Manon Maumus , Marianne Chevalier , Gladys Mirey et al.

Environmental and Molecular Mutagenesis, 2019, 60 (3), pp.286-297. ⟨10.1002/em.22268⟩

Article dans une revue hal-02620276v1
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Cytolethal distending toxin subunit B: A review of structure–function relationship

Benoît Pons , Julien Vignard , Gladys Mirey

Toxins, 2019, 11 (10), 20 p. ⟨10.3390/toxins11100595⟩

Article dans une revue hal-02618477v1
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A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

Alan D. d'Andrea , Laure Guitton-Sert , Mariline Béliveau , Kalindi Parmar , Jalila Chagraoui et al.

Nucleic Acids Research, 2019, 47 (14), pp.7532-7547. ⟨10.1093/nar/gkz514⟩

Article dans une revue hal-02915101v1
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Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not

Benoît Pons , Elisabeth Bezine , Mélissa Hanique , Valerie Guillet , Lionel Mourey et al.

PLoS ONE, 2019, 14 (3), pp.e0214313. ⟨10.1371/journal.pone.0214313⟩

Article dans une revue hal-02346660v1
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<em>Campylobacter jejuni</em> promotes colorectal tumorigenesis through the action of cytolethal distending toxin

Zhen He , Raad Z. Gharaibeh , Rachel C. Newsome , Jllian L. Pope , Michael W. Dougherty et al.

Gut, 2019, 68 (2), pp.289-300. ⟨10.1136/gutjnl-2018-317200⟩

Article dans une revue hal-02627995v1
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The colibactin genotoxin generates DNA interstrand cross-links in infected cells

Nadège Bossuet-Greif , Julien Vignard , Frederic Taieb , Gladys Mirey , Damien Dubois et al.

mBio, 2018, 9 (2), pp.e02393-17. ⟨10.1128/mBio.02393-17⟩

Article dans une revue hal-02627565v1

Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet

Benjamin Kopp , Julien Vignard , Gladys Mirey , Valérie Fessard , Daniel Zalko et al.

Environmental and Molecular Mutagenesis, 2018, 59 (8), pp.1-13. ⟨10.1002/em.22214⟩

Article dans une revue anses-01880114v1

Use of a reliable metabolically competent human rghep(+) hepatocyte model engineered with biological tracers for in vitro micronucleus test associating high-content imaging<strong></strong>

Vanessa Graillot , Thibault Metenier , Odile Mondésert , Julien Vignard , Valérie Lobjois et al.

Drug Metabolism and Pharmacokinetics, 2018, 33 (1), pp.S59. ⟨10.1016/j.dmpk.2017.11.200⟩

Article dans une revue hal-02618768v1
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Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes

Marie Liamin , Elisa Boutet-Robinet , Emilien L. Jamin , Morgane Fernier , Laure Khoury et al.

Biochemical Pharmacology, 2017, 137, pp.113-124. ⟨10.1016/j.bcp.2017.04.025⟩

Article dans une revue hal-01560145v1
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Around and beyond 53BP1 nuclear bodies

Anne Fernandez-Vidal , Julien Vignard , Gladys Mirey

International Journal of Molecular Sciences, 2017, 18 (12), ⟨10.3390/ijms18122611⟩

Article dans une revue hal-02619788v1

A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging

Vanessa Graillot , Odile Mondésert , Thibault Metenier , Julien Vignard , Valerie Lobjois et al.

Toxicology Letters, 2016, 258, pp.S146. ⟨10.1016/j.toxlet.2016.06.1566⟩

Article dans une revue istex hal-01602870v1
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Genotoxicity of cytolethal distending toxin (cdt) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis

Vanessa Graillot , Inge Dormoy , Jacques Dupuy , Jerry W. Shay , Laurence Huc et al.

Frontiers in Cellular and Infection Microbiology, 2016, 6, pp.1-13. ⟨10.3389/fcimb.2016.00034⟩

Article dans une revue hal-02635460v1
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Cell resistance to the cytolethal distending toxin involves an association of DNA repair mechanisms

Elisabeth Bezine , Yann Malaisé , Aurore Loeuillet , Marianne Chevalier , Elisa Boutet-Robinet et al.

Scientific Reports, 2016, 6, pp.1-15. ⟨10.1038/srep36022⟩

Article dans une revue hal-01602345v1

Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

Denis Jullien , Julien Vignard , Yoann Fedor , Nicolas Béry , Aurélien Olichon et al.

Development (Cambridge, England), 2016, 143 (14), ⟨10.1242/dev.141804⟩

Article dans une revue hal-01602858v1
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Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells

Denis Jullien , Julien Vignard , Yoann Fedor , Nicolas Béry , Aurélien Olichon et al.

Journal of Cell Science, 2016, 129 (13), pp.2673-2683. ⟨10.1242/jcs.183103⟩

Article dans une revue hal-01602848v1
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The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective.

Elisabeth Bezine , Julien Vignard , Gladys Mirey

Cells, 2014, 3 (2), pp.592-615. ⟨10.3390/cells3020592⟩

Article dans une revue hal-01192559v1

Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up

Julien Vignard , Gladys Mirey , Bernard Salles

Radiotherapy & Oncology, 2013, 108 (3), pp.362-369. ⟨10.1016/j.radonc.2013.06.013⟩

Article dans une revue hal-02648277v1

From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin

Yoann Fedor , Julien Vignard , Marie-Laure Travers , Elisa Boutet-Robinet , Claude Watrin et al.

Cellular Microbiology, 2013, 15 (1), pp.1 - 15. ⟨10.1111/cmi.12028⟩

Article dans une revue hal-02647902v1
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PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks

Jana Krietsch , Marie Christine Caron , Jean-Philippe Gagné , Chantal Ethier , Julien Vignard et al.

Nucleic Acids Research, 2012, 40 (20), pp.10287-301. ⟨10.1093/nar/gks798⟩

Article dans une revue hal-01137043v1

Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA

Julien Vignard , Corinne Charbonnel , Jean-Yves Masson

Cell Cycle, 2011, 10 (7), pp.1025-1026. ⟨10.4161/cc.10.7.15212⟩

Article dans une revue hal-02643095v1
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SHOC1 and PTD form an XPF-ERCC1-like complexthat is required for formation of class I crossovers

Nicolas N. Macaisne , Julien Vignard , Raphaël R. Mercier

Journal of Cell Science, 2011, 124 (Pt 16), pp.2687-2691. ⟨10.1242/jcs.088229⟩

Article dans une revue hal-01000742v1
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Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis

François Roudier , Lionel Gissot , Frédéric Beaudoin , Richard Haslam , Louise V. Michaelson et al.

The Plant cell, 2010, 22 (2), pp.364-375. ⟨10.1105/tpc.109.071209⟩

Article dans une revue hal-00856101v1
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The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.

Ramachander V. N. Turaga , Eric R. Paquet , Mari Sild , Julien Vignard , Chantal Garand et al.

Cell Cycle, 2009, 8 (13), pp.2080-2092. ⟨10.4161/cc.8.13.8925⟩

Article dans une revue hal-02655604v1
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MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair

Céline Roques , Yan Coulombe , Mathieu Delannoy , Julien Vignard , Simona Grossi et al.

EMBO Journal, 2009, 28 (16), pp.2400-2413. ⟨10.1038/emboj.2009.193⟩

Article dans une revue hal-02662125v1
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Outcrossing as an explanation of the apparent unconventional genetic behavior of <em>Arabidopsis thaliana</em> hth mutants

Raphaël Mercier , Sylvie Jolivet , Julien Vignard , Stéphanie Durand , Jan Drouaud et al.

Genetics, 2008, 180 (4), pp.2295-2297. ⟨10.1534/genetics.108.095208⟩

Article dans une revue hal-02656582v1

AtMSH5 partners AtMSH4 in the class I meiotic crossover pathway in <em>Arabidopsis thaliana</em>, but is not required for synapsis

James D. Higgins , Julien Vignard , Raphaël Mercier , Alice G. Pugh , F. Chris H. Franklin et al.

The Plant Journal, 2008, 55 (1), pp.28-39. ⟨10.1111/j.1365-313X.2008.03470.x⟩

Article dans une revue hal-02661925v1
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The road to crossovers: plants have their say

Christine Mézard , Julien Vignard , Jan Drouaud , Raphaël Mercier

Trends in Genetics, 2007, 23 (2), pp.91-99. ⟨10.1016/j.tig.2006.12.007⟩

Article dans une revue (article de synthèse) hal-02668854v1
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The interplay of RecA-related proteins and the MND1-HOP2 complex during meiosis in <em>Arabidopsis thaliana</em>

Julien Vignard , Tanja Siwiec , Liudmila Chelysheva , Nathalie Vrielynck , Florine Gonord et al.

PLoS Genetics, 2007, 3 (10), pp.1894-906. ⟨10.1371/journal.pgen.0030176⟩

Article dans une revue hal-02661109v1

The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination

C. Kerzendorfer , Julien Vignard , A. Pedrosa-Harand , T. Siwiec , S. Akimcheva et al.

Journal of Cell Science, 2006, 119 (12), pp.2486-2496. ⟨10.1242/jcs.02967⟩

Article dans une revue hal-02664509v1

Alterations in sphingolipid synthesis in the model plant Arabidopsis thaliana is associated with cell polarity and developmental defects

François Roudier , Lionel L. Gissot , Julien Vignard , Christine Rochat , Patrick Moreau et al.

Chemistry and Physics of Lipids, 2006, 143 (1-2), pp.100

Article dans une revue hal-02657873v1

The effect of Cytolethal Distending Toxin from Gram-negative bacteria on mammalian cells.

Elisabeth Bezine , Julien Vignard , Gladys Mirey

Prokaryotes: Physiology, Biochemistry and Cell Behavior., Nova science, 2014

Chapitre d'ouvrage hal-02792518v1

In vitro micronucleus test in living cells associating biological tracers and high-content imaging

Gladys Mirey , Vanessa Graillot , Odile Mondésert , Thibault Metenier , Julien Vignard et al.

53. Congress of the European-Societies-of-Toxicology (EUROTOX), Sep 2017, Bratislava, Slovakia. pp.1, ⟨10.1016/j.toxlet.2017.08.072⟩

Communication dans un congrès hal-02735959v1

L’analyse des voies de réparation nous renseigne sur les dommages à l’ADN induits par la toxine CDT

Elisabeth Bezine , Julien Vignard , Yann Malaisé , Aurore Loeuillet , Elisa Boutet-Robinet et al.

Journée des doctorants de l'INRA Toxalim, Jun 2015, Toulouse, France

Communication dans un congrès hal-02800134v1

The bacterial cytolethal distending Toxin induces indirect double-strand breaks into eukaryotic cells

Elisabeth Bezine , Julien Vignard , Marianne Chevalier , Elisa Boutet-Robinet , Bernard Salles et al.

Journée de l’ecole Doctorale SEVAB, Mar 2015, Toulouse, France

Communication dans un congrès hal-02796083v1

VHH-based universal histone binding domains: novel tools for a different look on and manipulation of chromatin

Denis Jullien , Julien Vignard , Yoann Fedor , Aurélien Olichon , Bernard Salles et al.

FEBS EMBO 2014 Conférence, Aug 2014, Paris, France. 823 p

Communication dans un congrès hal-02741249v1

Nanobody-based universal histone binding domains for chromatin imaging and editing

Denis Jullien , Julien Vignard , Yoann Fedor , Aurélien Olichon , Michèle Crozatier et al.

4. Biosensor Meeting of the Biosensor Group of the GDR 2588 Microscopie et Imagerie du Vivant, May 2014, Bordeaux, France

Communication dans un congrès hal-02793548v1

Genotoxicity and repair: the cytolethal distending toxin model

Elisabeth Bezine , Yoann Fedor , Julien Vignard , Elisa Boutet-Robinet , Bernard Salles et al.

4? workshop "Genome, Structure and Functions", Hôpital Rangueil. FRA., Apr 2013, Toulouse, France

Communication dans un congrès hal-02809832v1

Développement de nouveaux outils de détection non-invasive des cassures double brin de l’ADN

Denis Jullien , Julien Vignard , Gladys Mirey , Bernard Ducommun

Réunion du groupe Biosenseur GDR2588, Groupe Biosenseur GDR2588., Mar 2012, Montpellier, France

Communication dans un congrès hal-02807599v1
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Human TR146 cells and pig buccal mucosa to assess oral transmucosal passage and buccal toxicity of foodgrade titanium dioxide

Julien Vignard , Aurélie Pettes-Duler , Eric Gaultier , Christel Cartier , Laurent Weingarten et al.

The XVIth International Congress of Toxicology, Sep 2022, Maastricht, Netherlands

Poster de conférence hal-03778286v1

Charcuterie et nitrosylation du fer héminique : toxicité in vitro du fer nitrosylé.

Jacques Dupuy , Julien Vignard , Tina Kostka , Gladys Mirey , Françoise Guéraud et al.

Journées Francophones de Nutrition, Nov 2022, Toulouse, France

Poster de conférence hal-04206466v1

Exposome alimentaire : la mycotoxine déoxynivalénol augmente la génotoxicité du fer héminique.

Delphine Payros , Marion Garofalo , Michel Baker , Marie Penary , Julien Vignard et al.

Journées Francophones de Nutrition, Nov 2022, Toulouse, France

Poster de conférence hal-04206504v1

Cellular study of a bacterial DNA-damaging virulence factor, the Cytolethal Distending Toxin

Benoît Pons , Julien Vignard , Elisabeth Bezine , Jean-Sébastien Dupuy , Saleha Hashim et al.

EuroScience Open Forum, Jul 2018, Toulouse, France. , 2018

Poster de conférence hal-02789185v1
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Cellular study of a bacterial DNA-damaging virulence factor, the cytolethal distending toxin

Benoît Pons , Julien Vignard , Elisabeth Bezine , Saleha Hashim , Valérie Lobjois et al.

Young Life Scientists’ Symposium on Genome Integrity, Nov 2018, Montpellier, France. 2018

Poster de conférence hal-02787088v1

Cytolethal Distending Toxin (CDT) exhibits a unique ability to induce micronucleus in infected cells: possible implications regarding activation of the inflammatory response

Julien Vignard , Benoît Pons , Anne Fernandez-Vidal , Gladys Mirey

DINGO, Jun 2018, Paris, France. , 2018

Poster de conférence hal-02790628v1

Overview of the DNA repair pathways involved in response to the cytolethal distending toxin

Elisabeth Bezine , Julien Vignard , Marianne Chevalier , Elisa Boutet-Robinet , Bernard Salles et al.

The 6th EMBO Meeting, Sep 2015, Birmingham, United Kingdom. 2015

Poster de conférence hal-02740247v1

Overview of the DNA repair pathways involved in the response to the cytolethal distending toxin

Julien Vignard , Elisabeth Bezine , Gladys Mirey , Bernard Salles , Elisa Boutet-Robinet et al.

11th 3R Meeting, May 2015, Giens, France. pp.1, 2015

Poster de conférence hal-02793078v1

The bacterial cytolethal distending toxin: a nuclease inducing indirect DNA double-strand breaks into eukaryotic cells

Elisabeth Bezine , Yoann Fedor , Julien Vignard , Elisa Boutet-Robinet , Bernard Salles et al.

FEBS EMBO 2014 Conférence, Aug 2014, Paris, France. 2014

Poster de conférence hal-02740249v1

A new mode of action of a bacterial genotoxin: the cytolethal distending toxin

Elisabeth Bezine , Yoann Fedor , Julien Vignard , Elisa Boutet-Robinet , Bernard Salles et al.

Journée Ecole Doctorale SEVAB, Nov 2013, Toulouse, France. 2013

Poster de conférence hal-02806633v1

A new mode of action for the cytolethal distending toxin

Elisabeth Bezine , Yoann Fedor , Julien Vignard , Elisa Boutet-Robinet , Bernard Salles et al.

5. EMBO Meeting, Sep 2013, Amsterdam, Netherlands. 2013

Poster de conférence hal-02748175v1

Effets génotoxiques de la cytolethal distending toxin et mécanismes de signalisations

Elisabeth Bezine , Yoann Fedor , Julien Vignard , Elisa Boutet-Robinet , Bernard Salles et al.

Journées des Microbiologistes de l’INRA 2012, Nov 2012, Avignon, France. 2012

Poster de conférence hal-02746646v1