Pierre Layrolle

Directeur de recherche Inserm - ToNIC UMR 1214 Chef d'équipe 3D Chip 'Regeneration osseuse, Bio-impression 3D de tissus et organoïdes humains sur puces'
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Affiliation actuelle
  • Toulouse NeuroImaging Center (ToNIC)
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Présentation

Pierre Layrolle has extensive experience in tissue engineering research both in industry and academia. He obtained his PhD in biomaterials in 1994 at the Polytechnic National Institute of Toulouse (FR) and his thesis was awarded the Leopold Escande prize. He completed his postdoctoral studies in Japan and later joined the tissue engineering company IsoTis (NL) prior to enter INSERM in Nantes. He was awarded the Jean Leray prize from the European Society for Biomaterials in 2007 and the 'Etoile de l'Europe' award from the French Ministry of Research in 2015. He recently moved to ToNIC to conduct research in 3D bioprinting of human osteoarticular tissues and brain organoids. Pierre Layrolle is inventor of 15 patents, authored about 250 peer-reviewed publications, member of the Editorial board of several journals (Acta Biomaterialia, Biomedical Materials, J Mater Sci Mater Med, Scientific Reports, Front Bioeng Biotech) and regularly invited to present at international conferences. He has also organized as chairman several conferences such as the European Society for Biomaterials in 2006, Bioceramics 20 in 2007, the European Orthopaedic Research Society conference in 2014 and the TERMIS workshop 3D bioprinting in cancer research in 2019.

Domaines de recherche

Sciences du Vivant [q-bio] Biologie cellulaire Ingénierie biomédicale Biomatériaux

Publications

Publications

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Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial

Mariano Sanz , Cecilie Gjerde , Bjørn Tore Gjertsen , Alberto Ortiz‐vigón , Nerea Sanchez et al.

Clinical Oral Implants Research, 2025, 36 (11), pp.1498-1514. ⟨10.1111/clr.70025⟩

Article dans une revue hal-05524774v1
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The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy

Pierre Layrolle , Christophe Orssaud , Maryse Leleu , Pierre Payoux , Stéphane Chavanas

Biomedicines, 2024, 12 (3), pp.584. ⟨10.3390/biomedicines12030584⟩

Article dans une revue hal-04620523v1
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Phase composition of calcium phosphate materials affects bone formation by modulating osteoclastogenesis

Paul Humbert , Carina Kampleitner , Julien de Lima , Meadhbh Á Brennan , Irene Lodoso-Torrecilla et al.

Acta Biomaterialia, 2024, 176, pp.417 - 431. ⟨10.1016/j.actbio.2024.01.022⟩

Article dans une revue hal-04591297v1
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Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models

Marianna Gavriiloglou , Mira Hammad , Jordan M Iliopoulos , Pierre Layrolle , Danae A Apatzidou

Journal of Functional Biomaterials, 2024, 15 (11), pp.330. ⟨10.3390/jfb15110330⟩

Article dans une revue hal-05517442v1

Microbial–stem cell interactions in periodontal disease

Jordan Iliopoulos , Pierre Layrolle , Danae Apatzidou

Journal of Medical Microbiology, 2022, 71 (4), ⟨10.1099/jmm.0.001503⟩

Article dans une revue hal-04703063v1
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Message in a Scaffold: Natural Biomaterials for Three-Dimensional (3D) Bioprinting of Human Brain Organoids

Pierre Layrolle , Pierre Payoux , Stéphane Chavanas

Biomolecules, 2022, 13 (1), pp.25. ⟨10.3390/biom13010025⟩

Article dans une revue hal-04703014v1
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A Comparative In Vitro and In Vivo Study of Osteogenicity by Using Two Biomaterials and Two Human Mesenchymal Stem Cell Subtypes

L. Fievet , N. Serratrice , Bénédicte Brulin , L. Giraudo , J. Véran et al.

Frontiers in Cell and Developmental Biology, 2022, 10, pp.913539. ⟨10.3389/fcell.2022.913539⟩

Article dans une revue hal-04703060v1

Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects

Meadhbh Á. Brennan , David Monahan , Bénédicte Brulin , Sara Gallinetti , Paul Humbert et al.

Acta Biomaterialia, 2021, 135, pp.689-704. ⟨10.1016/j.actbio.2021.09.007⟩

Article dans une revue hal-04685957v1
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Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Paul Humbert , Meadhbh Á. Brennan , Julien de Lima , Régis Brion , Annie Adrait et al.

Scientific Reports, 2021, 11 (1), pp.12144. ⟨10.1038/s41598-021-91258-4⟩

Article dans une revue hal-04703070v1
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Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics

Meadhbh Á Brennan , Mario Barilani , Francesco Rusconi , Julien de Lima , Luciano Vidal et al.

Scientific Reports, 2021, 11 (1), pp.6751. ⟨10.1038/s41598-021-86147-9⟩

Article dans une revue hal-04699769v1
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Osteonecrosis of the Femoral Head Safely Healed with Autologous, Expanded, Bone Marrow-Derived Mesenchymal Stromal Cells in a Multicentric Trial with Minimum 5 Years Follow-Up

Enrique Gómez-Barrena , Norma Padilla-Eguiluz , Philippe Rosset , Philippe Hernigou , Nicola Baldini et al.

Journal of Clinical Medicine, 2021, 10 (3), pp.508. ⟨10.3390/jcm10030508⟩

Article dans une revue hal-04699836v1
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PPAR Gamma and Viral Infections of the Brain

Pierre Layrolle , Pierre Payoux , Stéphane Chavanas

International Journal of Molecular Sciences, 2021, 22 (16), pp.8876. ⟨10.3390/ijms22168876⟩

Article dans une revue hal-04693529v1
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Evaluation of the Chemotherapy Drug Response Using Organotypic Cultures of Osteosarcoma Tumours from Mice Models and Canine Patients

Bénédicte Brulin , John C Nolan , Tecla Marangon , Milan Kovacevic , Mathias Chatelais et al.

Cancers, 2021, 13 (19), pp.4890. ⟨10.3390/cancers13194890⟩

Article dans une revue hal-04693150v1
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Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma

Miguel Mateu-Sanz , Juan Tornín , Bénédicte Brulin , Anna Khlyustova , Maria-Pau Ginebra et al.

Cancers, 2020, 12 (1), pp.227. ⟨10.3390/cancers12010227⟩

Article dans une revue hal-04703122v1
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Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds

Luciano Vidal , Carina Kampleitner , Stéphanie Krissian , Meadhbh A Brennan , Oskar Hoffmann et al.

Scientific Reports, 2020, 10 (1), pp.7068. ⟨10.1038/s41598-020-63742-w⟩

Article dans une revue inserm-02873399v1

A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect

Fiona Freeman , Meadhbh Á Brennan , David Browe , Audrey Renaud , Julien de Lima et al.

Frontiers in Bioengineering and Biotechnology, 2020, 8, pp.230. ⟨10.3389/fbioe.2020.00230⟩

Article dans une revue hal-04703108v1
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Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Luciano Vidal , Carina Kampleitner , Meadhbh A Brennan , Alain Hoornaert , Pierre Layrolle

Frontiers in Bioengineering and Biotechnology, 2020, 8, pp.61. ⟨10.3389/fbioe.2020.00061⟩

Article dans une revue inserm-02880917v1

Early efficacy evaluation of mesenchymal stromal cells (MSC) combined to biomaterials to treat long bone non-unions

Enrique Gómez-Barrena , Norma Padilla-Eguiluz , Philippe Rosset , Florian Gebhard , Philippe Hernigou et al.

Injury, 2020, 51, pp.S63-S73. ⟨10.1016/j.injury.2020.02.070⟩

Article dans une revue hal-04703112v1

Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

Meadhbh Á Brennan , Pierre Layrolle , David Mooney

Advanced Functional Materials, 2020, 30 (37), ⟨10.1002/adfm.201909125⟩

Article dans une revue hal-04703094v1

Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration

Mariano Sanz , Christer Dahlin , Danae Apatzidou , Zvi Artzi , Darko Bozic et al.

Journal of Clinical Periodontology, 2019, 46 (S21), pp.82-91. ⟨10.1111/jcpe.13123⟩

Article dans une revue hal-04703135v1
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Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data

Markus Thomas Rojewski , Ramin Lotfi , Cecilie Gjerde , Kamal Mustafa , Elena Veronesi et al.

Cytotherapy, 2019, 21 (4), pp.468-482. ⟨10.1016/j.jcyt.2019.03.001⟩

Article dans une revue hal-04703145v1

Biomarkers of bone healing induced by a regenerative approach based on expanded bone marrow–derived mesenchymal stromal cells

Donatella Granchi , Gabriela Ciapetti , Enrique Gómez-Barrena , Markus Rojewski , Philippe Rosset et al.

Cytotherapy, 2019, 21 (8), pp.870-885. ⟨10.1016/j.jcyt.2019.06.002⟩

Article dans une revue hal-04703132v1
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Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration

Paul Humbert , Meadhbh A Brennan , Noel Davison , Philippe Rosset , Valérie Trichet et al.

Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00663⟩

Article dans une revue inserm-02148414v1
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Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats

Alain Hoornaert , Yassine Maazouz , David Pastorino , Carlos Aparicio , Gonzague de Pinieux et al.

Tissue Engineering Part C: Methods, 2019, 25 (1), pp.1-11. ⟨10.1089/ten.tec.2018.0260⟩

Article dans une revue hal-02103189v1

Nanostructured surface coatings for titanium alloy implants

Guy Louarn , Laëtitia Salou , Alain Hoornaert , Pierre Layrolle

Journal of Materials Research, 2019, 34 (11), pp.1892-1899. ⟨10.1557/jmr.2019.39⟩

Article dans une revue hal-02271143v1
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Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells

Salwa Suliman , Hassan Ali , Tommy Karlsen , Jerome Amiaud , Samih Mohamed-Ahmed et al.

Scientific Reports, 2019, 9 (1), pp.16031. ⟨10.1038/s41598-019-52442-9⟩

Article dans une revue hal-04703127v1
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Feasibility and safety of treating non-unions in tibia, femur and humerus with autologous, expanded, bone marrow-derived mesenchymal stromal cells associated with biphasic calcium phosphate biomaterials in a multicentric, non-comparative trial

Enrique Gomez-Barrena , Philippe Rosset , Florian Gebhard , Philippe Hernigou , Nicola Baldini et al.

Biomaterials, 2018, epub ahead of print. ⟨10.1016/j.biomaterials.2018.03.033⟩

Article dans une revue inserm-01782929v1
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Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma

Louis-Romée Le Nail , Meadhbh A Brennan , Philippe Rosset , Frédéric Deschaseaux , Philippe Piloquet et al.

International Journal of Molecular Sciences, 2018, 19 (3), pp.707. ⟨10.3390/ijms19030707⟩

Article dans une revue inserm-01724638v1
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Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial

Cecilie Gjerde , Kamal Mustafa , Sølve Hellem , Markus Rojewski , Harald Gjengedal et al.

Current Stem Cell Research & Therapy, 2018, 9 (1), pp.213. ⟨10.1186/s13287-018-0951-9⟩

Article dans une revue inserm-01859562v1
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Early fracture healing is delayed in the Col1a2+/G610C osteogenesis imperfecta murine model

Besio Roberta , Sylvia Maruelli , Séverine Battaglia , Laura Leoni , Simona Villani et al.

Calcified Tissue International, 2018, Epub ahead of print. ⟨10.1007/s00223-018-0461-x⟩

Article dans une revue inserm-01859541v1
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Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Donatella Granchi , Enrique Gómez-Barrena , Markus Rojewski , Philippe Rosset , Pierre Layrolle et al.

Stem Cells International, 2017, 2017, Epub ahead of print. ⟨10.1155/2017/3674045⟩

Article dans une revue inserm-01671301v1
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Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells

Fiona E Freeman , Jessica Schiavi , Meadhbh A Brennan , Peter Owens , Pierre Layrolle et al.

Tissue Engineering: Parts A, B, and C, 2017, 23 (23-24), pp.1466 - 1478. ⟨10.1089/ten.tea.2017.0052⟩

Article dans une revue inserm-01671244v1

Inferior In Vivo Osteogenesis and Superior Angiogeneis of Human Adipose Tissue: A Comparison with Bone Marrow-Derived Stromal Stem Cells Cultured in Xeno-Free Conditions

Meadhbh A Brennan , Audrey Renaud , Fabien Guilloton , Miryam Mebarki , Valérie Trichet et al.

Stem Cells Translational Medicine, 2017, 6 (12), pp.2160 - 2172. ⟨10.1002/sctm.17-0133⟩

Article dans une revue inserm-01668944v1
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IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro.

Marie-Astrid Boutet , Aurelie Najm , Géraldine Bart , Régis Brion , Sophie Touchais et al.

Annals of the Rheumatic Diseases, 2017, 76 (7), pp.1304-1312. ⟨10.1136/annrheumdis-2016-210630⟩

Article dans une revue inserm-01671438v1
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Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation.

Miryam Mebarki , Laura Coquelin , Pierre Layrolle , Séverine Battaglia , Marine Tossou et al.

Acta Biomaterialia, 2017, 59, pp.94-107. ⟨10.1016/j.actbio.2017.06.018⟩

Article dans une revue hal-01577907v1
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Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration

Alain Hoornaert , Cyril D’arros , Marie-Françoise Heymann , Pierre Layrolle

Biomedical Materials, 2016, 11 (4), pp.045012. ⟨10.1088/1748-6041/11/4/045012⟩

Article dans une revue inserm-01702004v1
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Bone regeneration strategies with bone marrow stromal cells in orthopaedic surgery

Julien Stanovici , Louis Romée Le Nail , Luciano Vidal , Meadhbh A Brennan , Valérie Trichet et al.

Current Research in Translational Medicine, 2016, 64 (2), pp.83 - 90. ⟨10.1016/j.retram.2016.04.006⟩

Article dans une revue inserm-01702061v1
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Enhanced osseointegration of titanium implants with nanostructured surfaces: An experimental study in rabbits

Laëtitia Salou , Alain Hoornaert , Guy Louarn , Pierre Layrolle

Acta Biomaterialia, 2015, 11, pp.494 - 502. ⟨10.1016/j.actbio.2014.10.017⟩

Article dans une revue inserm-01793581v1
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Comparative bone tissue integration of nanostructured and microroughened dental implants

Laëtitia Salou , Alain Hoornaert , Julien Stanovici , Sylvain Briand , Guy Louarn et al.

Nanomedicine, 2015, 10 (5), pp.741 - 751. ⟨10.2217/NNM.14.223⟩

Article dans une revue inserm-01793585v1
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Controlled implant/soft tissue interaction by nanoscale surface modifications of 3D porous titanium implants

Elisabeth Rieger , Agnès Dupret-Bories , Laetitia Salou , Marie-Hélène Metz-Boutigue , Pierre Layrolle et al.

Nanoscale, 2015, 7 (21), pp.9908 - 9918. ⟨10.1039/c5nr01237f⟩

Article dans une revue inserm-01793588v1
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Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs

Thomas Cordonnier , Alain Langonné , Pierre Corre , Audrey Renaud , Luc Sensebe et al.

Journal of Tissue Engineering and Regenerative Medicine, 2014, 8 (5), pp.364-76. ⟨10.1002/term.1529⟩

Article dans une revue istex inserm-01847272v1

EFFECTS OF A NOVEL CERAMIC BIOMATERIAL ON IMMUNE MODULATORY PROPERTIES AND DIFFERENTIATION POTENTIAL OF MESENCHYMAL STROMAL CELLS

Giulio Bassi , Fabien Guilloton , Cédric Ménard , Mariano Di Trapani , Luciano Pacelli et al.

Cytotherapy, 2014, 16 (4), pp.S90-S91. ⟨10.1016/j.jcyt.2014.01.336⟩

Article dans une revue istex hal-00988244v1
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Computational model combined with in vitro experiments to analyse mechanotransduction during mesenchymal stem cell adhesion

Jean-Louis Milan , Sandrine Lavenus , Paul Pilet , Guy Louarn , Sylvie Wendling et al.

eCells and Materials Journal, 2013, 25, pp.97-113. ⟨10.22203/eCM.v025a07⟩

Article dans une revue hal-02284008v1
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Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate.

Meadhbh Á Brennan , Audrey Renaud , Jérôme Amiaud , Markus T Rojewski , Hubert Schrezenmeier et al.

Current Stem Cell Research & Therapy, 2013, 5 (5), pp.114. ⟨10.1186/scrt504⟩

Article dans une revue inserm-01205389v1

Healing of long-bone defects in sheep metatarsals using bioceramics and mesenchymal stem cells

Thomas Cordonnier , Jérôme Sohier , Luc Sensebé , Pierre Layrolle , Philippe Rosset

Current Orthopaedic Practice, 2012, 23 (4), pp.369-376. ⟨10.1097/BCO.0b013e318259e847⟩

Article dans une revue hal-02373941v1

Consistent Osteoblastic Differentiation of Human Mesenchymal Stem Cells with Bone Morphogenetic Protein 4 and Low Serum

Thomas Cordonnier , Alain Langonné , Jérôme Sohier , Pierre Layrolle , Philippe Rosset et al.

Tissue Engineering Part C: Methods, 2011, 17 (3), pp.249-259. ⟨10.1089/ten.tec.2010.0387⟩

Article dans une revue hal-02373947v1

Bone Regeneration Using Porous Titanium Particles versus Bovine Hydroxyapatite: A Sinus Lift Study in Rabbits

France Lambert , Geoffrey Lecloux , Angelique Léonard , Sophie Sourice , Pierre Layrolle et al.

Clinical Implant Dentistry and Related Research, 2011, 15 (3), pp.412-426. ⟨10.1111/j.1708-8208.2011.00374.x⟩

Article dans une revue istex hal-05261845v1

Biomimetic Materials for Bone Tissue Engineering - State of the Art and Future Trends

Thomas Cordonnier , Jérôme Sohier , Philippe Rosset , Pierre Layrolle

Advanced Engineering Materials, 2011, 13 (5), pp.B135-B150. ⟨10.1002/adem.201080098⟩

Article dans une revue istex hal-02373943v1

Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering

Jérôme Sohier , Guy Daculsi , Sophie Sourice , Klaas de Groot , Pierre Layrolle

Journal of Biomedical Materials Research Part A, 2009, 9999A, pp.NA-NA. ⟨10.1002/jbm.a.32467⟩

Article dans une revue istex hal-02373949v1

Rapid prototyped porous titanium coated with calcium phosphate as a scaffold for bone tissue engineering

Marco Lopez-Heredia , Jérôme Sohier , Cédric Gaillard , Sophie Quillard , Michel Dorget et al.

Biomaterials, 2008, 29 (17), pp.2608-2615. ⟨10.1016/j.biomaterials.2008.02.021⟩

Article dans une revue istex hal-02373967v1
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Bone repair using a new injectable self-crosslinkable bone substitute.

Borhane H. Fellah , Pierre Weiss , Olivier Gauthier , Thierry Rouillon , Paul Pilet et al.

Journal of Orthopaedic Research, 2006, 24 (4), pp.628-35. ⟨10.1002/jor.20125⟩

Article dans une revue inserm-00170238v1