Pierre Layrolle

Directeur de recherche Inserm - ToNIC UMR 1214 Chef d'équipe 3D Chip 'Regeneration osseuse, Bio-impression 3D de tissus et organoïdes humains sur puces'
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Affiliation actuelle
  • Toulouse NeuroImaging Center (ToNIC)
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Présentation

Pierre Layrolle has extensive experience in tissue engineering research both in industry and academia. He obtained his PhD in biomaterials in 1994 at the Polytechnic National Institute of Toulouse (FR) and his thesis was awarded the Leopold Escande prize. He completed his postdoctoral studies in Japan and later joined the tissue engineering company IsoTis (NL) prior to enter INSERM in Nantes. He was awarded the Jean Leray prize from the European Society for Biomaterials in 2007 and the 'Etoile de l'Europe' award from the French Ministry of Research in 2015. He recently moved to ToNIC to conduct research in 3D bioprinting of human osteoarticular tissues and brain organoids. Pierre Layrolle is inventor of 15 patents, authored about 250 peer-reviewed publications, member of the Editorial board of several journals (Acta Biomaterialia, Biomedical Materials, J Mater Sci Mater Med, Scientific Reports, Front Bioeng Biotech) and regularly invited to present at international conferences. He has also organized as chairman several conferences such as the European Society for Biomaterials in 2006, Bioceramics 20 in 2007, the European Orthopaedic Research Society conference in 2014 and the TERMIS workshop 3D bioprinting in cancer research in 2019.

Domaines de recherche

Sciences du Vivant [q-bio] Biologie cellulaire Ingénierie biomédicale Biomatériaux

Publications

Publications

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Phase composition of calcium phosphate materials affects bone formation by modulating osteoclastogenesis

Paul Humbert , Carina Kampleitner , Julien de Lima , Meadhbh Á Brennan , Irene Lodoso-Torrecilla et al.
Acta Biomaterialia, 2024, 176, pp.417 - 431. ⟨10.1016/j.actbio.2024.01.022⟩
Article dans une revue hal-04591297 v1

Microbial–stem cell interactions in periodontal disease

Jordan Iliopoulos , Pierre Layrolle , Danae Apatzidou
Journal of Medical Microbiology, 2022, 71 (4), ⟨10.1099/jmm.0.001503⟩
Article dans une revue hal-04703063 v1

Osteonecrosis of the Femoral Head Safely Healed with Autologous, Expanded, Bone Marrow-Derived Mesenchymal Stromal Cells in a Multicentric Trial with Minimum 5 Years Follow-Up

Enrique Gómez-Barrena , Norma Padilla-Eguiluz , Philippe Rosset , Philippe Hernigou , Nicola Baldini et al.
Journal of Clinical Medicine, 2021, 10 (3), pp.508. ⟨10.3390/jcm10030508⟩
Article dans une revue hal-04703089 v1
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Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Paul Humbert , Meadhbh Á. Brennan , Julien de Lima , Régis Brion , Annie Adrait et al.
Scientific Reports, 2021, 11 (1), pp.12144. ⟨10.1038/s41598-021-91258-4⟩
Article dans une revue hal-04703070 v1

Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics

Meadhbh Á. Brennan , Mario Barilani , Francesco Rusconi , Julien de Lima , Luciano Vidal et al.
Scientific Reports, 2021, 11 (1), pp.6751. ⟨10.1038/s41598-021-86147-9⟩
Article dans une revue hal-04703082 v1

PPAR Gamma and Viral Infections of the Brain

Pierre Layrolle , Pierre Payoux , Stéphane Chavanas
International Journal of Molecular Sciences, 2021, 22 (16), pp.8876. ⟨10.3390/ijms22168876⟩
Article dans une revue hal-04703067 v1

Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects

Meadhbh Á. Brennan , David Monahan , Bénédicte Brulin , Sara Gallinetti , Paul Humbert et al.
Acta Biomaterialia, 2021, 135, pp.689-704. ⟨10.1016/j.actbio.2021.09.007⟩
Article dans une revue hal-04703065 v1

Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma

Miguel Mateu-Sanz , Juan Tornín , Bénédicte Brulin , Anna Khlyustova , Maria-Pau Ginebra et al.
Cancers, 2020, 12 (1), pp.227. ⟨10.3390/cancers12010227⟩
Article dans une revue hal-04703122 v1
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Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds

Luciano Vidal , Carina Kampleitner , Stéphanie Krissian , Meadhbh A Brennan , Oskar Hoffmann et al.
Scientific Reports, 2020, 10 (1), pp.7068. ⟨10.1038/s41598-020-63742-w⟩
Article dans une revue inserm-02873399 v1

A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect

Fiona Freeman , Meadhbh Á. Brennan , David Browe , Audrey Renaud , Julien de Lima et al.
Frontiers in Bioengineering and Biotechnology, 2020, 8, ⟨10.3389/fbioe.2020.00230⟩
Article dans une revue hal-04703108 v1

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Luciano Vidal , Carina Kampleitner , Meadhbh Á. Brennan , Alain Hoornaert , Pierre Layrolle
Frontiers in Bioengineering and Biotechnology, 2020, 8, ⟨10.3389/fbioe.2020.00061⟩
Article dans une revue hal-04703116 v1

Biocompatibility and osseointegration of nanostructured titanium dental implants in minipigs

Alain Hoornaert , Luciano Vidal , Romain Besnier , Jean‐francois Morlock , Guy Louarn et al.
Clinical Oral Implants Research, 2020, 31 (6), pp.526-535. ⟨10.1111/clr.13589⟩
Article dans une revue hal-04703118 v1

Osteoblasts mineralization and collagen matrix are conserved upon specific Col1a2 silencing

Silvia Maruelli , Roberta Besio , Julie Rousseau , Nadia Garibaldi , Jérôme Amiaud et al.
Matrix Biology Plus, 2020, 6-7, pp.100028. ⟨10.1016/j.mbplus.2020.100028⟩
Article dans une revue hal-04703085 v1

Early efficacy evaluation of mesenchymal stromal cells (MSC) combined to biomaterials to treat long bone non-unions

Enrique Gómez-Barrena , Norma Padilla-Eguiluz , Philippe Rosset , Florian Gebhard , Philippe Hernigou et al.
Injury, 2020, 51, pp.S63-S73. ⟨10.1016/j.injury.2020.02.070⟩
Article dans une revue hal-04703112 v1
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Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Luciano Vidal , Carina Kampleitner , Meadhbh A Brennan , Alain Hoornaert , Pierre Layrolle
Frontiers in Bioengineering and Biotechnology, 2020, 8, pp.61. ⟨10.3389/fbioe.2020.00061⟩
Article dans une revue inserm-02880917 v1

Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds

Luciano Vidal , Carina Kampleitner , Stéphanie Krissian , Meadhbh Á Brennan , Oskar Hoffmann et al.
Scientific Reports, 2020, 10 (1), pp.7068. ⟨10.1038/s41598-020-63742-w⟩
Article dans une revue hal-04703104 v1

Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

Meadhbh Á. Brennan , Pierre Layrolle , David Mooney
Advanced Functional Materials, 2020, 30 (37), ⟨10.1002/adfm.201909125⟩
Article dans une revue hal-04703094 v1
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Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data

Markus Thomas Rojewski , Ramin Lotfi , Cecilie Gjerde , Kamal Mustafa , Elena Veronesi et al.
Cytotherapy, 2019, 21 (4), pp.468-482. ⟨10.1016/j.jcyt.2019.03.001⟩
Article dans une revue hal-04703145 v1

Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration

Mariano Sanz , Christer Dahlin , Danae Apatzidou , Zvi Artzi , Darko Bozic et al.
Journal of Clinical Periodontology, 2019, 46 (S21), pp.82-91. ⟨10.1111/jcpe.13123⟩
Article dans une revue hal-04703135 v1
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Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats

Alain Hoornaert , Yassine Maazouz , David Pastorino , Carlos Aparicio , Gonzague de Pinieux et al.
Tissue Engineering Part C: Methods, 2019, 25 (1), ⟨10.1089/ten.tec.2018.0260⟩
Article dans une revue hal-02103189 v1

Biomarkers of bone healing induced by a regenerative approach based on expanded bone marrow–derived mesenchymal stromal cells

Donatella Granchi , Gabriela Ciapetti , Enrique Gómez-Barrena , Markus Rojewski , Philippe Rosset et al.
Cytotherapy, 2019, 21 (8), pp.870-885. ⟨10.1016/j.jcyt.2019.06.002⟩
Article dans une revue hal-04703132 v1
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Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration

Paul Humbert , Meadhbh A Brennan , Noel Davison , Philippe Rosset , Valérie Trichet et al.
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00663⟩
Article dans une revue inserm-02148414 v1

Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration

Paul Humbert , Meadhbh Á. Brennan , Noel Davison , Philippe Rosset , Valérie Trichet et al.
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00663⟩
Article dans une revue hal-04703139 v1

Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner

Christelle Darrieutort-Laffite , Paul Arnolfo , Thomas Garraud , Annie Adrait , Yohann Couté et al.
Journal of Clinical Medicine, 2019, 8 (10), pp.1544. ⟨10.3390/jcm8101544⟩
Article dans une revue hal-04703130 v1

Nanostructured surface coatings for titanium alloy implants

Guy Louarn , Laëtitia Salou , Alain Hoornaert , Pierre Layrolle
Journal of Materials Research, 2019, 34 (11), pp.1892-1899. ⟨10.1557/jmr.2019.39⟩
Article dans une revue hal-02271143 v1
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Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells

Salwa Suliman , Hassan Ali , Tommy Karlsen , Jerome Amiaud , Samih Mohamed-Ahmed et al.
Scientific Reports, 2019, 9 (1), pp.16031. ⟨10.1038/s41598-019-52442-9⟩
Article dans une revue hal-04703127 v1

Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats

Alain Hoornaert , Yassine Maazouz , David Pastorino , Carlos Aparicio , Gonzague de Pinieux et al.
Tissue Engineering Part C: Methods, 2019, 25 (1), pp.1-11. ⟨10.1089/ten.TEC.2018.0260⟩
Article dans une revue hal-04703148 v1
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Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial

Cecilie Gjerde , Kamal Mustafa , Sølve Hellem , Markus Rojewski , Harald Gjengedal et al.
Current Stem Cell Research & Therapy, 2018, 9 (1), pp.213. ⟨10.1186/s13287-018-0951-9⟩
Article dans une revue inserm-01859562 v1
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Early fracture healing is delayed in the Col1a2+/G610C osteogenesis imperfecta murine model

Besio Roberta , Sylvia Maruelli , Séverine Battaglia , Laura Leoni , Simona Villani et al.
Calcified Tissue International, 2018, Epub ahead of print. ⟨10.1007/s00223-018-0461-x⟩
Article dans une revue inserm-01859541 v1
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Feasibility and safety of treating non-unions in tibia, femur and humerus with autologous, expanded, bone marrow-derived mesenchymal stromal cells associated with biphasic calcium phosphate biomaterials in a multicentric, non-comparative trial

Enrique Gomez-Barrena , Philippe Rosset , Florian Gebhard , Philippe Hernigou , Nicola Baldini et al.
Biomaterials, 2018, epub ahead of print. ⟨10.1016/j.biomaterials.2018.03.033⟩
Article dans une revue inserm-01782929 v1
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Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma

Louis-Romée Le Nail , Meadhbh A Brennan , Philippe Rosset , Frédéric Deschaseaux , Philippe Piloquet et al.
International Journal of Molecular Sciences, 2018, 19 (3), pp.707. ⟨10.3390/ijms19030707⟩
Article dans une revue inserm-01724638 v1
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IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro.

Marie-Astrid Boutet , Aurelie Najm , Géraldine Bart , Régis Brion , Sophie Touchais et al.
Annals of the Rheumatic Diseases, 2017, 76 (7), pp.1304-1312. ⟨10.1136/annrheumdis-2016-210630⟩
Article dans une revue inserm-01671438 v1
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Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation.

Miryam Mebarki , Laura Coquelin , Pierre Layrolle , Séverine Battaglia , Marine Tossou et al.
Acta Biomaterialia, 2017, 59, pp.94-107. ⟨10.1016/j.actbio.2017.06.018⟩
Article dans une revue hal-01577907 v1
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Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Donatella Granchi , Enrique Gómez-Barrena , Markus Rojewski , Philippe Rosset , Pierre Layrolle et al.
Stem Cells International, 2017, 2017, Epub ahead of print. ⟨10.1155/2017/3674045⟩
Article dans une revue inserm-01671301 v1
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Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration

Alain Hoornaert , Cyril D’arros , Marie-Françoise Heymann , Pierre Layrolle
Biomedical Materials, 2016, 11 (4), pp.045012. ⟨10.1088/1748-6041/11/4/045012⟩
Article dans une revue inserm-01702004 v1
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Bone regeneration strategies with bone marrow stromal cells in orthopaedic surgery

Julien Stanovici , Louis Romée Le Nail , Luciano Vidal , Meadhbh A Brennan , Valérie Trichet et al.
Current Research in Translational Medicine, 2016, 64 (2), pp.83 - 90. ⟨10.1016/j.retram.2016.04.006⟩
Article dans une revue inserm-01702061 v1
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Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs

Thomas Cordonnier , Alain Langonné , Pierre Corre , Audrey Renaud , Luc Sensebe et al.
Journal of Tissue Engineering and Regenerative Medicine, 2014, 8 (5), pp.364-76. ⟨10.1002/term.1529⟩
Article dans une revue istex inserm-01847272 v1
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Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate.

Meadhbh Á Brennan , Audrey Renaud , Jérôme Amiaud , Markus T Rojewski , Hubert Schrezenmeier et al.
Current Stem Cell Research & Therapy, 2013, 5 (5), pp.114. ⟨10.1186/scrt504⟩
Article dans une revue inserm-01205389 v1