Pierre Layrolle

Directeur de recherche Inserm - ToNIC UMR 1214 Chef d'équipe 3D Chip 'Regeneration osseuse, Bio-impression 3D de tissus et organoïdes humains sur puces'
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Libre accès
88
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Affiliation actuelle
  • Toulouse NeuroImaging Center (ToNIC)
Identifiants chercheurs
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Présentation

Pierre Layrolle has extensive experience in tissue engineering research both in industry and academia. He obtained his PhD in biomaterials in 1994 at the Polytechnic National Institute of Toulouse (FR) and his thesis was awarded the Leopold Escande prize. He completed his postdoctoral studies in Japan and later joined the tissue engineering company IsoTis (NL) prior to enter INSERM in Nantes. He was awarded the Jean Leray prize from the European Society for Biomaterials in 2007 and the 'Etoile de l'Europe' award from the French Ministry of Research in 2015. He recently moved to ToNIC to conduct research in 3D bioprinting of human osteoarticular tissues and brain organoids. Pierre Layrolle is inventor of 15 patents, authored about 250 peer-reviewed publications, member of the Editorial board of several journals (Acta Biomaterialia, Biomedical Materials, J Mater Sci Mater Med, Scientific Reports, Front Bioeng Biotech) and regularly invited to present at international conferences. He has also organized as chairman several conferences such as the European Society for Biomaterials in 2006, Bioceramics 20 in 2007, the European Orthopaedic Research Society conference in 2014 and the TERMIS workshop 3D bioprinting in cancer research in 2019.

Domaines de recherche

Sciences du Vivant [q-bio] Biologie cellulaire Ingénierie biomédicale Biomatériaux

Publications

Publications

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Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial

Mariano Sanz , Cecilie Gjerde , Bjørn Tore Gjertsen , Alberto Ortiz‐vigón , Nerea Sanchez et al.

Clinical Oral Implants Research, 2025, 36 (11), pp.1498-1514. ⟨10.1111/clr.70025⟩

Article dans une revue hal-05524774v1
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The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy

Pierre Layrolle , Christophe Orssaud , Maryse Leleu , Pierre Payoux , Stéphane Chavanas

Biomedicines, 2024, 12 (3), pp.584. ⟨10.3390/biomedicines12030584⟩

Article dans une revue hal-04620523v1
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Phase composition of calcium phosphate materials affects bone formation by modulating osteoclastogenesis

Paul Humbert , Carina Kampleitner , Julien de Lima , Meadhbh Á Brennan , Irene Lodoso-Torrecilla et al.

Acta Biomaterialia, 2024, 176, pp.417 - 431. ⟨10.1016/j.actbio.2024.01.022⟩

Article dans une revue hal-04591297v1
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Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models

Marianna Gavriiloglou , Mira Hammad , Jordan M Iliopoulos , Pierre Layrolle , Danae A Apatzidou

Journal of Functional Biomaterials, 2024, 15 (11), pp.330. ⟨10.3390/jfb15110330⟩

Article dans une revue hal-05517442v1
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Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells

Loïc Fiévet , Nicolas Espagnolle , Daniela Gerovska , David Bernard , Charlotte Syrykh et al.

Current Stem Cell Research & Therapy, 2023, 14 (1), pp.229. ⟨10.1186/s13287-023-03437-x⟩

Article dans une revue hal-04266407v1

Microbial–stem cell interactions in periodontal disease

Jordan Iliopoulos , Pierre Layrolle , Danae Apatzidou

Journal of Medical Microbiology, 2022, 71 (4), ⟨10.1099/jmm.0.001503⟩

Article dans une revue hal-04703063v1
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Message in a Scaffold: Natural Biomaterials for Three-Dimensional (3D) Bioprinting of Human Brain Organoids

Pierre Layrolle , Pierre Payoux , Stéphane Chavanas

Biomolecules, 2022, 13 (1), pp.25. ⟨10.3390/biom13010025⟩

Article dans une revue hal-04703014v1
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A Comparative In Vitro and In Vivo Study of Osteogenicity by Using Two Biomaterials and Two Human Mesenchymal Stem Cell Subtypes

L. Fievet , N. Serratrice , Bénédicte Brulin , L. Giraudo , J. Véran et al.

Frontiers in Cell and Developmental Biology, 2022, 10, pp.913539. ⟨10.3389/fcell.2022.913539⟩

Article dans une revue hal-04703060v1

A Functional in Vitro 3D Model of Human Hematopoietic Niches

Melanie Gadelorge , Frederic Deschaseaux , Jean-Gerard Descamps , Alexandra Grimaldi , Pierre Layrolle et al.

Blood, 2022, 140 (Supplement 1), pp.5778-5779. ⟨10.1182/blood-2022-162236⟩

Article dans une revue hal-04819358v1

Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects

Meadhbh Á. Brennan , David Monahan , Bénédicte Brulin , Sara Gallinetti , Paul Humbert et al.

Acta Biomaterialia, 2021, 135, pp.689-704. ⟨10.1016/j.actbio.2021.09.007⟩

Article dans une revue hal-04685957v1
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Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics

Meadhbh Á Brennan , Mario Barilani , Francesco Rusconi , Julien de Lima , Luciano Vidal et al.

Scientific Reports, 2021, 11 (1), pp.6751. ⟨10.1038/s41598-021-86147-9⟩

Article dans une revue hal-04699769v1
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Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Paul Humbert , Meadhbh Á. Brennan , Julien de Lima , Régis Brion , Annie Adrait et al.

Scientific Reports, 2021, 11 (1), pp.12144. ⟨10.1038/s41598-021-91258-4⟩

Article dans une revue hal-04703070v1
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Osteonecrosis of the Femoral Head Safely Healed with Autologous, Expanded, Bone Marrow-Derived Mesenchymal Stromal Cells in a Multicentric Trial with Minimum 5 Years Follow-Up

Enrique Gómez-Barrena , Norma Padilla-Eguiluz , Philippe Rosset , Philippe Hernigou , Nicola Baldini et al.

Journal of Clinical Medicine, 2021, 10 (3), pp.508. ⟨10.3390/jcm10030508⟩

Article dans une revue hal-04699836v1
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PPAR Gamma and Viral Infections of the Brain

Pierre Layrolle , Pierre Payoux , Stéphane Chavanas

International Journal of Molecular Sciences, 2021, 22 (16), pp.8876. ⟨10.3390/ijms22168876⟩

Article dans une revue hal-04693529v1
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Evaluation of the Chemotherapy Drug Response Using Organotypic Cultures of Osteosarcoma Tumours from Mice Models and Canine Patients

Bénédicte Brulin , John C Nolan , Tecla Marangon , Milan Kovacevic , Mathias Chatelais et al.

Cancers, 2021, 13 (19), pp.4890. ⟨10.3390/cancers13194890⟩

Article dans une revue hal-04693150v1
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Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma

Miguel Mateu-Sanz , Juan Tornín , Bénédicte Brulin , Anna Khlyustova , Maria-Pau Ginebra et al.

Cancers, 2020, 12 (1), pp.227. ⟨10.3390/cancers12010227⟩

Article dans une revue hal-04703122v1
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Osteoblasts mineralization and collagen matrix are conserved upon specific Col1a2 silencing

Silvia Maruelli , Roberta Besio , Julie Rousseau , Nadia Garibaldi , Jerome Amiaud et al.

Matrix Biology Plus, 2020, 6, pp.100028. ⟨10.1016/j.mbplus.2020.100028⟩

Article dans une revue hal-03292038v1
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Biocompatibility and osseointegration of nanostructured titanium dental implants in minipigs

Alain Hoornaert , Luciano Vidal , Romain Besnier , Jean‐francois Morlock , Guy Louarn et al.

Clinical Oral Implants Research, 2020, 31 (6), pp.526-535. ⟨10.1111/clr.13589⟩

Article dans une revue hal-02553588v1

A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect

Fiona Freeman , Meadhbh Á Brennan , David Browe , Audrey Renaud , Julien de Lima et al.

Frontiers in Bioengineering and Biotechnology, 2020, 8, pp.230. ⟨10.3389/fbioe.2020.00230⟩

Article dans une revue hal-04703108v1
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Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds

Luciano Vidal , Carina Kampleitner , Stéphanie Krissian , Meadhbh A Brennan , Oskar Hoffmann et al.

Scientific Reports, 2020, 10 (1), pp.7068. ⟨10.1038/s41598-020-63742-w⟩

Article dans une revue inserm-02873399v1
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Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Luciano Vidal , Carina Kampleitner , Meadhbh A Brennan , Alain Hoornaert , Pierre Layrolle

Frontiers in Bioengineering and Biotechnology, 2020, 8, pp.61. ⟨10.3389/fbioe.2020.00061⟩

Article dans une revue inserm-02880917v1

Early efficacy evaluation of mesenchymal stromal cells (MSC) combined to biomaterials to treat long bone non-unions

Enrique Gómez-Barrena , Norma Padilla-Eguiluz , Philippe Rosset , Florian Gebhard , Philippe Hernigou et al.

Injury, 2020, 51, pp.S63-S73. ⟨10.1016/j.injury.2020.02.070⟩

Article dans une revue hal-04703112v1
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In situ production of pre-vascularized synthetic bone grafts for regenerating critical-sized defects in rabbits

Luciano Vidal , Meadhbh Á Brennan , Stéphanie Krissian , Julien de Lima , Alain Hoornaert et al.

Acta Biomaterialia, 2020, 114, pp.384 - 394. ⟨10.1016/j.actbio.2020.07.030⟩

Article dans une revue hal-03492265v1

Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

Meadhbh Á Brennan , Pierre Layrolle , David Mooney

Advanced Functional Materials, 2020, 30 (37), ⟨10.1002/adfm.201909125⟩

Article dans une revue hal-04703094v1
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Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner

Christelle Darrieutort-Laffite , Paul Arnolfo , Thomas Garraud , Annie Adrait , Yohann Couté et al.

Journal of Clinical Medicine, 2019, 8 (10), pp.1544. ⟨10.3390/jcm8101544⟩

Article dans une revue hal-02375450v1
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Epinephrine Infiltration of Adipose Tissue Impacts MCF7 Breast Cancer Cells and Total Lipid Content

Pierre Avril , Luciano Vidal , Sophie Barille-Nion , Louis-Romée Le Nail , Françoise Rédini et al.

International Journal of Molecular Sciences, 2019, 20 (22), pp.E5626. ⟨10.3390/ijms20225626⟩

Article dans une revue inserm-02383856v1
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Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration

Paul Humbert , Meadhbh A Brennan , Noel Davison , Philippe Rosset , Valérie Trichet et al.

Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00663⟩

Article dans une revue inserm-02148414v1

Biomarkers of bone healing induced by a regenerative approach based on expanded bone marrow–derived mesenchymal stromal cells

Donatella Granchi , Gabriela Ciapetti , Enrique Gómez-Barrena , Markus Rojewski , Philippe Rosset et al.

Cytotherapy, 2019, 21 (8), pp.870-885. ⟨10.1016/j.jcyt.2019.06.002⟩

Article dans une revue istex hal-04703132v1
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Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats

Alain Hoornaert , Yassine Maazouz , David Pastorino , Carlos Aparicio , Gonzague de Pinieux et al.

Tissue Engineering Part C: Methods, 2019, 25 (1), pp.1-11. ⟨10.1089/ten.tec.2018.0260⟩

Article dans une revue hal-02103189v1
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Low-dose pesticide mixture induces accelerated mesenchymal stem cells aging in vitro

Xavier Lévêque , Mazène Hochane , Fanny Geraldo , Solene Dumont , Catherine Gratas et al.

STEM CELLS, 2019, 37 (8), pp.1083-1094. ⟨10.1002/stem.3014⟩

Article dans une revue inserm-02102559v1
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Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data

Markus Thomas Rojewski , Ramin Lotfi , Cecilie Gjerde , Kamal Mustafa , Elena Veronesi et al.

Cytotherapy, 2019, 21 (4), pp.468-482. ⟨10.1016/j.jcyt.2019.03.001⟩

Article dans une revue hal-04703145v1

Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration

Mariano Sanz , Christer Dahlin , Danae Apatzidou , Zvi Artzi , Darko Bozic et al.

Journal of Clinical Periodontology, 2019, 46 (S21), pp.82-91. ⟨10.1111/jcpe.13123⟩

Article dans une revue hal-04703135v1

Nanostructured surface coatings for titanium alloy implants

Guy Louarn , Laëtitia Salou , Alain Hoornaert , Pierre Layrolle

Journal of Materials Research, 2019, 34 (11), pp.1892-1899. ⟨10.1557/jmr.2019.39⟩

Article dans une revue hal-02271143v1
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Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells

Salwa Suliman , Hassan Ali , Tommy Karlsen , Jerome Amiaud , Samih Mohamed-Ahmed et al.

Scientific Reports, 2019, 9 (1), pp.16031. ⟨10.1038/s41598-019-52442-9⟩

Article dans une revue hal-04703127v1
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Feasibility and safety of treating non-unions in tibia, femur and humerus with autologous, expanded, bone marrow-derived mesenchymal stromal cells associated with biphasic calcium phosphate biomaterials in a multicentric, non-comparative trial

Enrique Gomez-Barrena , Philippe Rosset , Florian Gebhard , Philippe Hernigou , Nicola Baldini et al.

Biomaterials, 2018, epub ahead of print. ⟨10.1016/j.biomaterials.2018.03.033⟩

Article dans une revue inserm-01782929v1
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Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma

Louis-Romée Le Nail , Meadhbh A Brennan , Philippe Rosset , Frédéric Deschaseaux , Philippe Piloquet et al.

International Journal of Molecular Sciences, 2018, 19 (3), pp.707. ⟨10.3390/ijms19030707⟩

Article dans une revue inserm-01724638v1
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Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial

Cecilie Gjerde , Kamal Mustafa , Sølve Hellem , Markus Rojewski , Harald Gjengedal et al.

Current Stem Cell Research & Therapy, 2018, 9 (1), pp.213. ⟨10.1186/s13287-018-0951-9⟩

Article dans une revue inserm-01859562v1
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Early fracture healing is delayed in the Col1a2+/G610C osteogenesis imperfecta murine model

Besio Roberta , Sylvia Maruelli , Séverine Battaglia , Laura Leoni , Simona Villani et al.

Calcified Tissue International, 2018, Epub ahead of print. ⟨10.1007/s00223-018-0461-x⟩

Article dans une revue inserm-01859541v1
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Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Donatella Granchi , Enrique Gómez-Barrena , Markus Rojewski , Philippe Rosset , Pierre Layrolle et al.

Stem Cells International, 2017, 2017, Epub ahead of print. ⟨10.1155/2017/3674045⟩

Article dans une revue inserm-01671301v1
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Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells

Fiona E Freeman , Jessica Schiavi , Meadhbh A Brennan , Peter Owens , Pierre Layrolle et al.

Tissue Engineering: Parts A, B, and C, 2017, 23 (23-24), pp.1466 - 1478. ⟨10.1089/ten.tea.2017.0052⟩

Article dans une revue inserm-01671244v1
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IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro.

Marie-Astrid Boutet , Aurelie Najm , Géraldine Bart , Régis Brion , Sophie Touchais et al.

Annals of the Rheumatic Diseases, 2017, 76 (7), pp.1304-1312. ⟨10.1136/annrheumdis-2016-210630⟩

Article dans une revue inserm-01671438v1

Inferior In Vivo Osteogenesis and Superior Angiogeneis of Human Adipose Tissue: A Comparison with Bone Marrow-Derived Stromal Stem Cells Cultured in Xeno-Free Conditions

Meadhbh A Brennan , Audrey Renaud , Fabien Guilloton , Miryam Mebarki , Valérie Trichet et al.

Stem Cells Translational Medicine, 2017, 6 (12), pp.2160 - 2172. ⟨10.1002/sctm.17-0133⟩

Article dans une revue inserm-01668944v1
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Impact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites

France Lambert , Miljana Bacevic , Pierre Layrolle , Peter Schüpbach , Pierre Drion et al.

Clinical Oral Implants Research, 2017, 28 (10), pp.e201 - e207. ⟨10.1111/clr.12986⟩

Article dans une revue inserm-01701071v1
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Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation.

Miryam Mebarki , Laura Coquelin , Pierre Layrolle , Séverine Battaglia , Marine Tossou et al.

Acta Biomaterialia, 2017, 59, pp.94-107. ⟨10.1016/j.actbio.2017.06.018⟩

Article dans une revue hal-01577907v1

Fresh and in vitro osteodifferentiated human amniotic membrane, alone or associated with an additional scaffold, does not induce ectopic bone formation in Balb/c mice.

Romain Laurent , Aurélie Nallet , Benoit de Billy , Laurent Obert , Laurence Nicod et al.

Cell and Tissue Banking, 2017, 18 (1), pp.17-25. ⟨10.1007/s10561-016-9605-2⟩

Article dans une revue hal-01550368v1
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Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration

Alain Hoornaert , Cyril D’arros , Marie-Françoise Heymann , Pierre Layrolle

Biomedical Materials, 2016, 11 (4), pp.045012. ⟨10.1088/1748-6041/11/4/045012⟩

Article dans une revue inserm-01702004v1
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Bone regeneration strategies with bone marrow stromal cells in orthopaedic surgery

Julien Stanovici , Louis Romée Le Nail , Luciano Vidal , Meadhbh A Brennan , Valérie Trichet et al.

Current Research in Translational Medicine, 2016, 64 (2), pp.83 - 90. ⟨10.1016/j.retram.2016.04.006⟩

Article dans une revue inserm-01702061v1
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Comparative bone tissue integration of nanostructured and microroughened dental implants

Laëtitia Salou , Alain Hoornaert , Julien Stanovici , Sylvain Briand , Guy Louarn et al.

Nanomedicine, 2015, 10 (5), pp.741 - 751. ⟨10.2217/NNM.14.223⟩

Article dans une revue inserm-01793585v1
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Enhanced osseointegration of titanium implants with nanostructured surfaces: An experimental study in rabbits

Laëtitia Salou , Alain Hoornaert , Guy Louarn , Pierre Layrolle

Acta Biomaterialia, 2015, 11, pp.494 - 502. ⟨10.1016/j.actbio.2014.10.017⟩

Article dans une revue inserm-01793581v1
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ORTHOPAEDIC IMPLANT FAILURE Aseptic implant loosening: contributions and future challenges of mouse models in translational research

Luis Alberto Córdova , Verena Stresing , Bérengère Gobin , Philippe Rosset , Norbert Passuti et al.

Acta Biomaterialia, 2015, 13, pp.150 - 158. ⟨10.1042/CS20130338⟩

Article dans une revue inserm-01644792v1
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Mesenchymal stem cells increase proliferation but do not change quiescent state of osteosarcoma cells: Potential implications according to the tumor resection status

Pierre Avril , Louis-Romée Le Nail , Meadhbh A Brennan , Philippe Rosset , Gonzague de Pinieux et al.

Journal of Bone Oncology, 2015, 5 (1), pp.5 - 14. ⟨10.1016/j.jbo.2015.11.002⟩

Article dans une revue inserm-01792555v1
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3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds

Natasha Maurmann , Audrey Renaud , Anne-Laure Gamblin , Cyril D’arros , Steven Nedellec et al.

Biomedical Materials, 2015, 10 (4), pp.045019. ⟨10.1088/1748-6041/10/4/045019⟩

Article dans une revue hal-02466795v1
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Controlled implant/soft tissue interaction by nanoscale surface modifications of 3D porous titanium implants

Elisabeth Rieger , Agnès Dupret-Bories , Laetitia Salou , Marie-Hélène Metz-Boutigue , Pierre Layrolle et al.

Nanoscale, 2015, 7 (21), pp.9908 - 9918. ⟨10.1039/c5nr01237f⟩

Article dans une revue inserm-01793588v1

Allele-specific Col1a1 silencing reduces mutant collagen in fibroblasts from Brtl mouse, a model for classical osteogenesis imperfecta

Julie Rousseau , Roberta Gioia , Pierre Layrolle , Blandine Lieubeau , Dominique Heymann et al.

European Journal of Human Genetics, 2014, 22 (5), pp.667-674. ⟨10.1038/ejhg.2013.198⟩

Article dans une revue hal-02636696v1
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Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs

Thomas Cordonnier , Alain Langonné , Pierre Corre , Audrey Renaud , Luc Sensebe et al.

Journal of Tissue Engineering and Regenerative Medicine, 2014, 8 (5), pp.364-76. ⟨10.1002/term.1529⟩

Article dans une revue istex inserm-01847272v1

EFFECTS OF A NOVEL CERAMIC BIOMATERIAL ON IMMUNE MODULATORY PROPERTIES AND DIFFERENTIATION POTENTIAL OF MESENCHYMAL STROMAL CELLS

Giulio Bassi , Fabien Guilloton , Cédric Ménard , Mariano Di Trapani , Luciano Pacelli et al.

Cytotherapy, 2014, 16 (4), pp.S90-S91. ⟨10.1016/j.jcyt.2014.01.336⟩

Article dans une revue istex hal-00988244v1
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Computational model combined with in vitro experiments to analyse mechanotransduction during mesenchymal stem cell adhesion

Jean-Louis Milan , Sandrine Lavenus , Paul Pilet , Guy Louarn , Sylvie Wendling et al.

eCells and Materials Journal, 2013, 25, pp.97-113. ⟨10.22203/eCM.v025a07⟩

Article dans une revue hal-02284008v1
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Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate.

Meadhbh Á Brennan , Audrey Renaud , Jérôme Amiaud , Markus T Rojewski , Hubert Schrezenmeier et al.

Current Stem Cell Research & Therapy, 2013, 5 (5), pp.114. ⟨10.1186/scrt504⟩

Article dans une revue inserm-01205389v1

Healing of long-bone defects in sheep metatarsals using bioceramics and mesenchymal stem cells

Thomas Cordonnier , Jérôme Sohier , Luc Sensebé , Pierre Layrolle , Philippe Rosset

Current Orthopaedic Practice, 2012, 23 (4), pp.369-376. ⟨10.1097/BCO.0b013e318259e847⟩

Article dans une revue hal-02373941v1
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Adhesion and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Titanium Nanopores

Sandrine Lavenus , Martine Berreur , Valerie Trichet , Paul Pilet , Guy Louarn et al.

eCells and Materials Journal, 2011, 22, pp.84. ⟨10.22203/ecm.v022a07⟩

Article dans une revue hal-00849362v1

Consistent Osteoblastic Differentiation of Human Mesenchymal Stem Cells with Bone Morphogenetic Protein 4 and Low Serum

Thomas Cordonnier , Alain Langonné , Jérôme Sohier , Pierre Layrolle , Philippe Rosset et al.

Tissue Engineering Part C: Methods, 2011, 17 (3), pp.249-259. ⟨10.1089/ten.tec.2010.0387⟩

Article dans une revue hal-02373947v1

Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate

Xavier Struillou , Hervé Boutigny , Zahi Badran , Borhane Fellah , Olivier Gauthier et al.

Journal of Materials Science: Materials in Medicine, 2011, 22 (7), pp.1707-1717. ⟨10.1007/s10856-011-4344-1⟩

Article dans une revue istex hal-05063687v1

Bone Regeneration Using Porous Titanium Particles versus Bovine Hydroxyapatite: A Sinus Lift Study in Rabbits

France Lambert , Geoffrey Lecloux , Angelique Léonard , Sophie Sourice , Pierre Layrolle et al.

Clinical Implant Dentistry and Related Research, 2011, 15 (3), pp.412-426. ⟨10.1111/j.1708-8208.2011.00374.x⟩

Article dans une revue istex hal-05261845v1

Behaviour of mesenchymal stem cells, fibroblasts and osteoblasts on smooth surfaces

Sandrine Lavenus , Paul Pilet , Jerome Guicheux , Pierre Weiss , Guy Louarn et al.

Acta Biomaterialia, 2011, 7 (4), pp.1525. ⟨10.1016/j.actbio.2010.12.033⟩

Article dans une revue istex hal-00849383v1

Biomimetic Materials for Bone Tissue Engineering - State of the Art and Future Trends

Thomas Cordonnier , Jérôme Sohier , Philippe Rosset , Pierre Layrolle

Advanced Engineering Materials, 2011, 13 (5), pp.B135-B150. ⟨10.1002/adem.201080098⟩

Article dans une revue istex hal-02373943v1

The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties

Bruno Delorme , Emmanuel Nivet , Julien Gaillard , Thomas Häupl , Jochen Ringe et al.

Stem Cells and Development, 2010, 19 (6), pp.853--866. ⟨10.1089/scd.2009.0267⟩

Article dans une revue hal-01736210v1

Macrophage and osteoblast responses to biphasic calcium phosphate microparticles

Borhane Hakim Fellah , Bruno Delorme , Jã©rã´me Sohier , David Magne , Pierre Hardouin et al.

Journal of Biomedical Materials Research Part A, 2010, 93A (4), pp.1588-1595. ⟨10.1002/jbm.a.32663⟩

Article dans une revue istex hal-02373955v1

Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering

Jérôme Sohier , Guy Daculsi , Sophie Sourice , Klaas de Groot , Pierre Layrolle

Journal of Biomedical Materials Research Part A, 2009, 9999A, pp.NA-NA. ⟨10.1002/jbm.a.32467⟩

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Rapid prototyped porous titanium coated with calcium phosphate as a scaffold for bone tissue engineering

Marco Lopez-Heredia , Jérôme Sohier , Cédric Gaillard , Sophie Quillard , Michel Dorget et al.

Biomaterials, 2008, 29 (17), pp.2608-2615. ⟨10.1016/j.biomaterials.2008.02.021⟩

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Radio frequency plasma treatments on titanium for enhancement of bioactivity

Marco Antonio Lopez-Heredia , Gilbert Legeay , Cédric Gaillard , Pierre Layrolle

Acta Biomaterialia, 2008, 4 (6), pp.1953-1962. ⟨10.1016/j.actbio.2008.04.024⟩

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Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model

Borhane Fellah , Olivier Gauthier , Pierre Weiss , Daniel Chappard , Pierre Layrolle

Biomaterials, 2008, 29 (9), pp.1177 - 1188. ⟨10.1016/j.biomaterials.2007.11.034⟩

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Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells

Bruno Delorme , Jochen Ringe , Nathalie Gallay , Yves Le Vern , Dominique Kerboeuf et al.

Blood, 2008, 111 (5), pp.2631-2635. ⟨10.1182/blood-2007-07-099622⟩

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Surface treatments of titanium dental implants for rapid osseointegration.

Laurent Le Guéhennec , Assem Soueidan , Pierre Layrolle , Yves Amouriq

Dental Materials, 2007, 23 (7), pp.844-54. ⟨10.1016/j.dental.2006.06.025⟩

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Inflammatory reaction in rats muscle after implantation of biphasic calcium phosphate micro particles.

Borhane H. Fellah , Nicolas Josselin , Daniel Chappard , Pierre Weiss , Pierre Layrolle

Journal of Materials Science: Materials in Medicine, 2007, 18 (2), pp.287-94. ⟨10.1007/s10856-006-0691-8⟩

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An electrodeposition method of calcium phosphate coatings on titanium alloy.

Marco Antonio Lopez-Heredia , Pierre Weiss , Pierre Layrolle

Journal of Materials Science: Materials in Medicine, 2007, 18 (2), pp.381-90. ⟨10.1007/s10856-006-0703-8⟩

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Osteogenic properties of calcium phosphate ceramics and fibrin glue based composites

Damien Le Nihouannen , Afchine Saffarzadeh , Eric Aguado , Eric Goyenvalle , Olivier Gauthier et al.

Journal of Materials Science: Materials in Medicine, 2007, 18 (2), pp.225-235. ⟨10.1007/s10856-006-0684-7⟩

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Protein mapping of calcium carbonate biominerals by immunogold.

Frédéric Marin , Boaz Pokroy , Gilles Luquet , Pierre Layrolle , Klaas de Groot

Biomaterials, 2007, 28 (14), pp.2368-77. ⟨10.1016/j.biomaterials.2007.01.029⟩

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Comparison of Osteoinduction by Autologous Bone and Biphasic Calcium Phosphate Ceramic in Goats

Borhane Fellah , Olivier Gauthier , Pierre Weiss , Daniel Chappard , Pierre Layrolle

Key Engineering Materials, 2007, 330-332, pp.1063-1066. ⟨10.4028/www.scientific.net/KEM.330-332.1063⟩

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Bone tissue formation in sheep muscles induced by a biphasic calcium phosphate ceramic and fibrin glue composite

Damien Le Nihouannen , Afchine Saffarzadeh , Olivier Gauthier , Françoise Moreau , Paul Pilet et al.

Journal of Materials Science: Materials in Medicine, 2007, 19 (2), pp.667-675. ⟨10.1007/s10856-007-3206-3⟩

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The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial.

Pierre Weiss , Pierre Layrolle , Léon Philippe Clergeau , Bénédicte Enckel , Paul Pilet et al.

Biomaterials, 2007, 28 (22), pp.3295-305. ⟨10.1016/j.biomaterials.2007.04.006⟩

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Hybrid composites of calcium phosphate granules, fibrin glue, and bone marrow for skeletal repair.

Damien Le Nihouannen , Eric Goyenvalle , Eric Aguado , Paul Pilet , Melitta Bilban et al.

Journal of Biomedical Materials Research Part A, 2007, 81 (2), pp.399-408. ⟨10.1002/jbm.a.31058⟩

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Cartilage and bone tissue engineering using hydrogels.

Claire Vinatier , Jérôme Guicheux , Guy Daculsi , Pierre Layrolle , Pierre Weiss

Bio-Medical Materials and Engineering, 2006, 16 (4 Suppl), pp.S107-13

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Bone repair using a new injectable self-crosslinkable bone substitute.

Borhane H. Fellah , Pierre Weiss , Olivier Gauthier , Thierry Rouillon , Paul Pilet et al.

Journal of Orthopaedic Research, 2006, 24 (4), pp.628-35. ⟨10.1002/jor.20125⟩

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Micro-architecture of calcium phosphate granules and fibrin glue composites for bone tissue engineering.

Damien Le Nihouannen , Laurent Le Guehennec , Thierry Rouillon , Paul Pilet , Melitta Bilban et al.

Biomaterials, 2006, 27 (13), pp.2716-22. ⟨10.1016/j.biomaterials.2005.11.038⟩

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Caspartin and calprismin, two proteins of the shell calcitic prisms of the Mediterranean fan mussel Pinna nobilis.

Frédéric Marin , Reinout Amons , Nathalie Guichard , Martin Stigter , Arnaud Hecker et al.

Journal of Biological Chemistry, 2005, 280 (40), pp.33895-908. ⟨10.1074/jbc.M506526200⟩

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