Luca Dirheimer

PhD Student. CRAN laboratory - Lorraine Institute of Oncology. Functionalization of near infrared Quantum Dots and fluorescence quantification on cell models: application to fluorescence-guided surgery of head and neck cancers
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Libre accès
6
Documents
Affiliations actuelles
  • Centre de Recherche en Automatique de Nancy (CRAN)
  • Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL)
Identifiants chercheurs

Présentation

PhD student at CRAN laboratory and Lorraine Institute of Oncology, I am working with Quantum Dots (QDs) to target 3D Head and Neck cancer spheroids as a part of a project willing to improve Fluorescence Guided Surgery. My project focuses on the development of 3D spheroid models and the characterization of QDs potential using flow cytometry and fluorescence microscopy analysis.

Before that, I graduated with a Master's degree in Life Sciences - Biotechnology - Cellular engineering at the Faculty of Science and Technology of Vandoeuvre-Lès-Nancy, France.

Domaines de recherche

Biologie cellulaire Biotechnologies Cancer

Compétences

3D Cell Culture - Spheroid Flow Cytometry Fluorescence Microscopy

Publications

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Publications

Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting

L. Dirheimer , S. Cortese , G. Dolivet , Jean-Louis Merlin , F. Marchal et al.
Molecular Diagnosis and Therapy, 2025, 29 (4), pp.465-481. ⟨10.1007/s40291-025-00781-x⟩
Article dans une revue hal-05400263 v1

Targeting of 3D oral cancer spheroids by αVβ6 integrin using near-infrared peptide-conjugated IRDye 680

Luca Dirheimer , Thomas Pons , Aurélie François , Laureline Lamy , Sophie Cortese et al.
Cancer Cell International, 2024, 24 (1), pp.228. ⟨10.1186/s12935-024-03417-y⟩
Article dans une revue hal-04636463 v1

Peptide-mediated targeting of Quantum Dots in a 3D model of head and neck cancer

Luca Dirheimer , Thomas Pons , Aurélie François , Laureline Lamy , Frédéric Marchal et al.
Photodiagnosis and Photodynamic Therapy, 2024, 49 (9), pp.104337. ⟨10.1016/j.pdpdt.2024.104337⟩
Article dans une revue hal-04838927 v1

A macrophages-enriched head and neck tumor spheroid model to study Foslip® behavior in tumor microenvironment

Aurélie François , Luca Dirheimer , Alicia Chateau , Henri-Pierre Lassalle , Ilya Yakavets et al.
International Journal of Nanomedicine, 2023, 18, pp.6545-6562. ⟨10.2147/IJN.S427350⟩
Article dans une revue hal-04291290 v1
Image document

Quantum dots mediated imaging and phototherapy in cancer spheroid models : state of the art and perspectives

Luca Dirheimer , Thomas Pons , Frédéric Marchal , Lina Bezdetnaya
Pharmaceutics, 2022, 14 (10), pp.2136. ⟨10.3390/pharmaceutics14102136⟩
Article dans une revue hal-03833131 v1