Mickael Di-Luoffo

Chercheur post-doctorant
49
Documents
Affiliations actuelles
  • Laboratoire d'analyse et d'architecture des systèmes (LAAS)
  • Centre de Recherches en Cancérologie de Toulouse (CRCT)
  • Centre de recherche du CHU de Québec-Université Laval (CRCHUQ)
  • Université Catholique de Louvain = Catholic University of Louvain (UCL)
  • de Duve Institute
Contact

Domaines de recherche

Sciences du Vivant [q-bio]

Compétences

Biologie moléculaire Biologie cellulaire Mécanobiologie Contraintes mécaniques Compression Cancer du pancréas Altérations génétiques Signalisation cellulaire PI3K Cholangiocarcinome Hepatocarcinome

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Publications

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Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells

Mickaël Di-Luoffo , Céline Schmitter , Emma C Barrere , Nicole Therville , Maria Chaouki et al.

Life Science Alliance, 2025, 8 (3), pp.e202402854. ⟨10.26508/lsa.202402854⟩

Article dans une revue hal-04874687v1
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A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding

Zacchari Ben Meriem , Tiphaine Mateo , Julien Faccini , Céline Denais , Romane Dusfour-Castan et al.

Lab on a Chip, 2023, 20, pp.4445-4455. ⟨10.1039/d3lc00313b⟩

Article dans une revue hal-04214597v1
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Transducing compressive forces into cellular outputs in cancer and beyond

Céline Schmitter , Mickaël Di-Luoffo , Julie Guillermet-Guibert

Life Science Alliance, 2023, 6 (9), pp.e202201862. ⟨10.26508/lsa.202201862⟩

Article dans une revue hal-04821449v1
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The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells

Mickaël Di-Luoffo , Kenley Joule Pierre , Nicholas M Robert , Marie-Joëlle Girard , Jacques J Tremblay

Reproduction [Cambridge], 2022, ⟨10.1530/rep-22-0109⟩

Article dans une revue hal-04891620v1
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PI3K functions as a hub in mechanotransduction

M. Di-Luoffo , Zacchari Ben-Meriem , P. Lefebvre , Morgan Delarue , Julie Guillermet-Guibert

Trends in Biochemical Sciences, 2021, 46 (11), pp.878-888. ⟨10.1016/j.tibs.2021.05.005⟩

Article dans une revue hal-03252135v1
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Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma

Claude Gérard , Mickaël Di-Luoffo , Léolo Gonay , Stefano Caruso , Gabrielle Couchy et al.

Journal of Hepatology, 2019, 71 (2), ⟨10.1016/j.jhep.2019.03.024⟩

Article dans une revue hal-04888966v1
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Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells1

Mickaël Di-Luoffo , Caroline Daems , Francis Bergeron , Jacques J Tremblay

Biology of Reproduction, 2015, 93 (1), ⟨10.1095/biolreprod.114.127761⟩

Article dans une revue hal-04891337v1

The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells

Mickaël Di-Luoffo , Catherine Brousseau , Francis Bergeron , Jacques J Tremblay

Endocrinology, 2015, 156 (12), pp.4695 - 4706. ⟨10.1210/en.2015-1500⟩

Article dans une revue hal-04891150v1
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MEF2 Cooperates With Forskolin/cAMP and GATA4 to Regulate Star Gene Expression in Mouse MA-10 Leydig Cells

Caroline Daems , Mickaël Di-Luoffo , Élise Paradis , Jacques J Tremblay

Endocrinology, 2015, 156 (7), pp.2693-2703. ⟨10.1210/en.2014-1964⟩

Article dans une revue hal-04891040v1

The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells

Raifish E Mendoza-Villarroel , Mickaël Di-Luoffo , Etienne Camiré , Xavier C Giner , Catherine Brousseau et al.

Journal of Molecular Endocrinology, 2014, 53 (1), pp.43-55. ⟨10.1530/jme-13-0290⟩

Article dans une revue hal-04890889v1

Impact of mechanical compressive stress on pancreatic cancer progression

Mickael Di-Luoffo , Silvia Arcucci , Tristan Marty , Nicole Therville , Sanzhar Aitbay et al.

de Duve institut (Brussels), de Duve institut, Jun 2025, Bruxelles, Belgium

Communication dans un congrès hal-05301039v1

PI3K signaling controls metabolic adaptations in pancreatic cancer

Coralie Cayron , Benoît Thibault , Silvia Arcucci , Mickael Di-Luoffo , Nicole Therville et al.

46th Symposium on hormones and cell regulation - Cancer signalling and metabolism, Oct 2024, Mont Sainte Odile, France

Communication dans un congrès hal-04922360v1

Imaging the 3D cellular effects of compression in oncology: Application in pancreatic cancer

Romina D’Angelo , Silvia Arcucci , Nicole Therville , Celine Denais , Morgan Delarue et al.

Atelier pour le 1st meeting of the France-BioImaging Mechanobiology WG, Mechanobiology Working Group FBI, Dec 2024, Toulouse, France

Communication dans un congrès hal-04908796v1

Oral bacteria accelerate pancreatic cancer development in mice

Mickael Di-Luoffo

38ième réunion du Club Français du Pancréas, Sep 2024, Toulouse, France

Communication dans un congrès hal-04908702v1

Mechanical stress & signal integration by PI3Ks for the control of tumour growth.

Sanzhar Aitbay , Hala Shalhoub , Romina D’Angelo , Nicole Therville , Silvia Arcucci et al.

4th PIPgen annual meeting, PIPgen, Sep 2024, Cambridge, United Kingdom

Communication dans un congrès hal-04924047v1

La plasticité épithéliale induite par l'inflammation peut être contournée par l'inactivation de Vps34 pour limiter l'initiation du cancer du pancréas

Benoît Thibault , Fernanda Ramos-Delgado , Hala Shalhoub , Camille Guyon , Charles Handschin et al.

Club Français du Pancréas, Sep 2023, Lille, France

Communication dans un congrès hal-04915308v1

Impact of mechanical compressive stress on pancreatic cancer progression

Mickael Di-Luoffo , Nicole Therville , Silvia Arcucci , Romina D’Angelo , Benoît Thibault et al.

Mechanobiology Club of Toulouse, Jan 2023, Toulouse, France

Communication dans un congrès hal-04908762v1

Mechanics & Genetics of pancreatic cancer Mechanical compressive stress favors selective mutational contexts and intracellular signaling during pancreatic cancer development

Mickael Di-Luoffo , Silvia Arcucci , Tristan Marty , Nicole Therville , Sanzhar Aitbay et al.

PANCREATIC CANCER SYMPOSIUM AFRCP 2023, Oct 2023, Bordeaux, France

Communication dans un congrès hal-04908777v1

Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation

Benoît Thibault , Fernanda Ramos-Delgado , Hala Shalhoub , Camille Guyon , Handschin Charles et al.

GSO Annual Meeting, Nov 2023, Arcachon, France

Communication dans un congrès hal-04915257v1

PI3Kα and PI3Kγ cooperation: a new target to limit metabolic heterogeneity in pancreatic cancer

Coralie Cayron , Benoît Thibault , Mickael Di-Luoffo , Nicole Therville , Camille Guyon et al.

Workshop oncogenic pathways in cancer, Mar 2023, Toulouse, France

Communication dans un congrès hal-04922379v1

Impact of mechanical compressive stress on pancreatic cancer progression

Mickael Di-Luoffo , Nicole Therville , Benoit Thibault , Morgan Delarue , Julie Guillermet-Guibert

Axe 1 : voies oncogéniques du cancer, Dec 2022, Toulouse, France

Communication dans un congrès hal-04908623v1

La croissance sous pression impacte la progression et le traitement du cancer du pancréas

Mickael Di-Luoffo , Nicole Therville , Sanzhar Aitbay , Pauline Lefebvre , Morgan Delarue et al.

Club Français du Pancréas 2022, Sep 2022, Paris, France

Communication dans un congrès hal-04908684v1

PI3K signaling and tumoral metabolism in pancreatic cancer

Coralie Cayron , Benoît Thibault , Mickael Di-Luoffo , Nicole Therville , Camille Guyon et al.

Congrès annuel de l'AFRCP, Nov 2021, Clichy, France

Communication dans un congrès hal-04922364v1

PI3K signaling and tumoral metabolism in pancreatic cancer

Coralie Cayron , Benoît Thibault , Mickael Di-Luoffo , Nicole Therville , Camille Guyon et al.

Congrès annuel du Cancéropole Grand Sud-Ouest, Nov 2021, Carcassonne, France

Communication dans un congrès hal-04922370v1

Tumor progression in bile duct cancer

Mickael Di-Luoffo , S Pirenne , T Saandi , A Loriot , C Gérard et al.

CRCT Scientific Animation, Jul 2020, Toulouse, France

Communication dans un congrès hal-04908585v1

MEF2 and COUP-TFII cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells

Mickaël Di-Luoffo , Catherine Brousseau , Raifish E. Mendoza Villarroel , Jacques J. Tremblay

RQR 2015, Nov 2015, Montreal (Canada), Canada

Communication dans un congrès hal-04906977v1

The MEF2 transcription factor regulates Gsta1 gene expression in MA-10 Leydig cells

Mickaël Di-Luoffo , Catherine Brousseau , Francis Bergeron , Jacques J. Tremblay

RQR 2014, Nov 2014, Québec (Canada), Canada

Communication dans un congrès hal-04906959v1

Pancreatic cancer cells adapt to compressive mechanical stress through regulation of PI3K – MAPK interdynamics.

Sanzhar Aitbay , Nicole Therville , Mickael Di-Luoffo , Hala Shalhoub , Romina D’Angelo et al.

48th FEBS Congress – ‘Mining biochemistry for human health and well-being’, Jun 2024, Milano, Italy. , 2024

Poster de conférence hal-04923950v1

PI3K signaling controls metabolic adaptations in pancreatic cancer

Benoît Thibault , Coralie Cayron , Mickael Di-Luoffo , Nicole Therville , Camille Guyon et al.

EACR Annual Meeting, Jun 2024, Rotterdam, Netherlands. 2024

Poster de conférence hal-04915342v1

PI3K signaling controls metabolic adaptations in pancreatic cancer

Coralie Cayron , Benoît Thibault , Silvia Arcucci , Mickael Di-Luoffo , Nicole Therville et al.

46th Symposium on Hormones and cell regulation - Cancer signalling and metabolism, Oct 2024, Mont Sainte Odile, France

Poster de conférence hal-04922358v1

Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer

Romina D’Angelo , Silvia Arcucci , Laetitia Ligat , Nicole Therville , Celine Denais et al.

Signaling, Microenvironment and Targeting - GSO Workshop, Feb 2024, Toulouse, France. 2024

Poster de conférence hal-04917240v1

“TREATING B CELL LYMPHOMA PATIENTS WITH INHIBITORS OF PI3Kδ (PHOSPHOINOSITIDE 3-KINASES): how to increase the efficacy?”

Maria Chaouki , Anne Quillet-Mary , Benoît Thibault , Loic Ysebaert , Michael Lahn et al.

46 th Symposium on Hormones and Cell Regulation, Oct 2024, STRASBOURG (FRANCE), France

Poster de conférence hal-04919848v1

Targeting PI3K pathway in pancreatic cancer reduces metabolic flexibility and sensitises tumour to new therapeutic strategies

Coralie Cayron , Benoît Thibault , Mickael Di-Luoffo , Nicole Therville , Camille Guyon et al.

PI3K pathway meeting, Sep 2023, Casteldefels, Barcelona, Spain

Poster de conférence hal-04922344v1

Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation

Benoît Thibault , Fernanda Ramos-Delgado , Hala Shalhoub , Camille Guyon , Charles Handschin et al.

Biochemical Society: PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, Barcelona, Spain. 2023

Poster de conférence hal-04915379v1

“TREATING B CELL LYMPHOMA PATIENTS WITH INHIBITORS OF PI3Kδ (PHOSPHOINOSITIDE 3-KINASES): how to increase the efficacy?”

Maria Chaouki , Anne Quillet-Mary , Loic Ysebaert , Benoît Thibault , Mickael Di-Luoffo et al.

PI3K/PTEN pathway: a new era in basic research & clinical translation, Sep 2023, BARCELONA, Spain

Poster de conférence hal-04919857v1

Imaging the 3D cellular effects of confinement in oncology: Application in pancreatic cancer

Romina D’Angelo , Silvia Arcucci , Laetitia Ligat , Nicole Therville , Celine Denais et al.

Multiscale Mechanobiology of Cells and Cell Systems, France Bio-Imaging Annual Meeting, Dec 2023, Centre de Biologie Intégrative of the UT3 – Paul Sabatier, Toulouse, France. , 2023

Poster de conférence hal-04920614v1

PI3K signaling controls metabolic adaptations in pancreatic cancer

Coralie Cayron , Benoît Thibault , Mickael Di-Luoffo , Nicole Therville , Camille Guyon et al.

Congrès annuel du Club Français du PAncréas, Sep 2022, Paris, France

Poster de conférence hal-04922329v1

PI3Kβ controls mechanical parameters of pancreatic tumours predictive of poor survival.

Sanzhar Aitbay , Nicole Therville , Silvia Arcucci , Pauline Lefebvre , Mickael Di-Luoffo et al.

EMBO | EMBL Symposium Mechanobiology in development and disease, May 2022, Heidelberg, Germany. 2022

Poster de conférence hal-04923995v1

PI3K signaling controls metabolic adaptations in pancreatic cancer

Coralie Cayron , Benoît Thibault , Mickael Di-Luoffo , Nicole Therville , Camille Guyon et al.

Abcam Cancer and Metabolism 2022, Jul 2022, Londres, United Kingdom

Poster de conférence hal-04922324v1

L’impact des contraintes mécaniques compressives sur la progression et le traitement du cancer du pancréas

Mickael Di-Luoffo , Pauline Lefebvre , Nicole Therville , Morgan Delarue , Julie Guillermet-Guibert

Club Français du Pancréas 2021, Sep 2021, Lyon, France. 2021

Poster de conférence hal-04908669v1

MEF2 regulates Nrf2 gene expression in mouse MA-10 Leydig cells

Nicholas M. Robert , Mickaël Di-Luoffo , Jacques J. Tremblay

ASA 2016, Apr 2016, Nouvelle Orléans (LA), United States

Poster de conférence hal-04906984v1

MEF2 and COUP-TFII cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells

Mickaël Di-Luoffo , Catherine Brousseau , Raifish E. Mendoza Villarroel , Jacques J. Tremblay

ASA 2015, Apr 2015, Salt lake city, UTAH, United States

Poster de conférence hal-04906964v1

Le facteur de transcription MEF2 (Myocyte Enhancer Factor 2) : un nouveau régulateur de l'expression de Gsta1 dans les cellules de Leydig MA-10

Mickaël Di-Luoffo , Catherine Brousseau , Francis Bergeron , Jacques J. Tremblay

Journée annuelle de la recherche Faculté de Médecine ULAVAL 2014, Mar 2014, Québec (Canada), Canada

Poster de conférence hal-04906949v1

The transcription factor MEF2 is a novel regulator of Gsta1 expression in MA-10 Leydig cells

Mickaël Di-Luoffo , Catherine Brousseau , Francis Bergeron , Jacques J. Tremblay

ASA 2014, Apr 2014, Atlanta (Georgia), United States

Poster de conférence hal-04906943v1

Rôle des facteurs de transcription MEF2 dans le maintien des fonctions stéroïdogéniques

Mickael Di-Luoffo , Catherine Brousseau , Francis Bergeron , Caroline Daems , J. Tremblay Jacques

Journée annuelle de la recherche Faculté de Médecine ULAVAL 2013, Jun 2013, Québec (Canada), Canada

Poster de conférence hal-04906861v1

Identification of target genes for the transcription factor myocyte enhancer factor 2 in MA-10 Leydig cells

Mickaël Di-Luoffo , Catherine Brousseau , Francis Bergeron , Caroline Daems , Jacques J. Tremblay

SSR 2013, Jul 2013, Montréal (Canada (QC)), Canada

Poster de conférence hal-04906899v1