Nicolas Lapaque

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Affiliation actuelle
  • MICrobiologie de l'ALImentation au Service de la Santé (MICALIS)
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Publications

Publications

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Anorexia nervosa symptoms are induced after specific gut microbiota dysbiosis transfer in germ-free mice

Tristan Gabriel-Segard , Christine Heberden , Stanislas Mondot , Maeva Duquesnoy , Marika Dicembre et al.

Gut microbes, 2025, 17 (1), pp.2563701. ⟨10.1080/19490976.2025.2563701⟩

Article dans une revue hal-05418639v1

Deciphering the mechanisms of action underlying probiotic properties of Shouchella clausii by a functional genomics approach

A. Lashermes , E. Mathieu , L. Marinelli , V. Léjard , E. Dervyn et al.

Beneficial Microbes, 2025, 16 (3), pp.347-362. ⟨10.1163/18762891-bja00050⟩

Article dans une revue hal-05322017v1

Adaptive immunity shapes innate and epithelial cell landscapes by silencing tonic IFN-γ in innate lymphoid cells during homeostasis

Ousséma Mejri , Li Ma , Amneh Aoudi , Ossama Labiad , Stanislas Mondot et al.

BioRxiv, In press, ⟨10.1101/2024.09.19.613869⟩

Article dans une revue hal-05401952v1

Role of pattern recognition receptors and microbiota-derived ligands in obesity

Alice Rolland , Véronique Douard , Nicolas N. Lapaque

Frontiers in Microbiomes, 2024, 3, ⟨10.3389/frmbi.2024.1324476⟩

Article dans une revue hal-04600251v1
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Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation

Camille Martin-Gallausiaux , Laurène Salesse , Diego Garcia-Weber , Ludovica Marinelli , Fabienne Beguet-Crespel et al.

Gut microbes, 2024, 16 (1), pp.2295384. ⟨10.1080/19490976.2023.2295384⟩

Article dans une revue hal-04484107v1
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An Insight into Functional Metagenomics: a High-Throughput Approach to Decipher Food–Microbiota–Host Interactions in the Human Gut

Elliot Mathieu , Véronique Léjard , Chaima Ezzine , Pauline Govindin , Aurélien Morat et al.

International Journal of Molecular Sciences, 2023, 24 (24), pp.17630. ⟨10.3390/ijms242417630⟩

Article dans une revue (article de synthèse) hal-04353544v1
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Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease

Florian Plaza Oñate , Célia Chamignon , Sebastian Burz , Nicolas Lapaque , Magali Monnoye et al.

International Journal of Molecular Sciences, 2023, 24 (15), pp.12232. ⟨10.3390/ijms241512232⟩

Article dans une revue hal-04214482v1
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Exposure to anti-seizure medications impact growth of gut bacterial species and subsequent host response

Zehra Esra Ilhan , Vincent Brochard , Nicolas Lapaque , Stéphane Auvin , Patricia Lepage

Neurobiology of Disease, 2022, 167, pp.105664. ⟨10.1016/j.nbd.2022.105664⟩

Article dans une revue hal-03954506v1
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<i>Akkermansia muciniphila</i> upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway

Camille Martin-Gallausiaux , Diego Garcia-Weber , Amandine Lashermes , Pierre Larraufie , Ludovica Marinelli et al.

Gut microbes, 2022, 14 (1), pp.2110639. ⟨10.1080/19490976.2022.2110639⟩

Article dans une revue hal-03787581v2
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Short Chain Fatty Acids – mechanisms and functional importance in the gut

Camille Martin-Gallausiaux , Ludovica Marinelli , Herve H. Blottiere , Pierre Larraufie , Nicolas Lapaque

Proceedings of the Nutrition Society, 2021, 80 (1), pp. 37-49. ⟨10.1017/S0029665120006916⟩

Article dans une revue hal-02536149v1
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Extracellular vesicles produced by the probiotic Propionibacterium freudenreichii CIRM-BIA 129 mitigate inflammation by modulating the NF-κB pathway

Vinicius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Houem Rabah , Fillipe Luiz Rosa Do Carmo , Edson L Folador et al.

Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.01544⟩

Article dans une revue hal-02885846v1
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Intestinal translocation of enterococci requires a threshold level of enterococcal overgrowth in the lumen

Cristel Archambaud , Aurelie Derre-Bobillot , Nicolas Lapaque , Lionel Rigottier-Gois , Pascale Serror

Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-45441-3⟩

Article dans une revue hal-02618379v1

Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism

Xufei Zhang , Alexandra Grosfeld , Edek Williams , Daniel Vasiliauskas , Sharon Barretto et al.

FASEB Journal, 2019, 33 (6), pp.7126-7142. ⟨10.1096/fj.201801526RR⟩

Article dans une revue hal-02191008v1
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Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells

Ludovica Marinelli , Camille Martin-Gallausiaux , Jean-Marie Bourhis , Fabienne Beguet-Crespel , Herve Blottiere et al.

Scientific Reports, 2019, 9 (1), pp.643. ⟨10.1038/s41598-018-37019-2⟩

Article dans une revue hal-01996381v1
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SCFAs strongly stimulate PYY production in human enteroendocrine cells

Pierre Larraufie , Camille Martin-Gallausiaux , Nicolas Lapaque , Joel Dore , F. M. Gribble et al.

Scientific Reports, 2018, 8, pp.1-9. ⟨10.1038/s41598-017-18259-0⟩

Article dans une revue hal-02628091v1
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Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells

Camille Martin-Gallausiaux , Fabienne Beguet-Crespel , Ludovica Marinelli , Alexandre Jamet , Florence Ledue et al.

Scientific Reports, 2018, 8, pp.1-13. ⟨10.1038/s41598-018-28048-y⟩

Article dans une revue hal-02624971v1
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Identification of New Factors Modulating Adhesion Abilities of the Pioneer Commensal Bacterium Streptococcus salivarius

Benoit Couvigny , Saulius Kulakauskas , Nicolas Pons , Benoit Quinquis , Anne-Laure Abraham et al.

Frontiers in Microbiology, 2018, 9 (article 273), ⟨10.3389/fmicb.2018.00273⟩

Article dans une revue hal-01713777v1
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Butyrate produced by commensal bacteria down-regulates indolamine 2, 3-dioxygenase 1 (IDO-1) expression via a dual mechanism in human intestinal epithelial cells

Camille Martin-Gallausiaux , Pierre Larraufie , Anne Jarry , Fabienne Beguet-Crespel , Ludovica Marinelli et al.

Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.02838⟩

Article dans une revue inserm-01937996v1
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Commensal gut bacteria modulate phosphorylation-dependent PPAR gamma transcriptional activity in human intestinal epithelial cells

Malgorzata Nepelska , Tomas T. de Wouters , Elsa Jacouton , Fabienne Beguet-Crespel , Nicolas Lapaque et al.

Scientific Reports, 2017, 7, ⟨10.1038/srep43199⟩

Article dans une revue hal-02628360v1
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TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways

Pierre Larraufie , Joel Dore , Nicolas Lapaque , Herve Blottiere

Cellular Microbiology, 2017, 19 (2), ⟨10.1111/cmi.12648⟩

Article dans une revue hal-01530823v1
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The Enterococcus faecalis virulence factor ElrA interacts with the human Four-and-a-Half LIM Domains Protein 2

Alexandre Jamet , Rozenn Dervyn , Nicolas Lapaque , Francesca Bugli , Naima Bermudez et al.

Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-04875-3⟩

Article dans une revue hal-01607001v1

Three glycosylated serine-rich repeat proteins play a pivotal role in adhesion and colonization of the pioneer commensal bacterium, Streptococcus salivarius

Benoit Couvigny , Nicolas N. Lapaque , Lionel Rigottier-Gois , Alain Guillot , Sophie Chat et al.

Environmental Microbiology, 2017, 19 (9), pp.3579-3594. ⟨10.1111/1462-2920.13853⟩

Article dans une revue hal-03031237v1

Three glycosylated serine-rich repeat proteins play a pivotal role in adhesion and colonization of the pioneer commensal bacterium, Streptococcus salivarius

Benoit Couvigny , Nicolas Lapaque , Lionel Rigottier-Gois , Alain Guillot , Sophie Chat et al.

Environmental Microbiology, 2017, 19 (9), pp.3579-3594. ⟨10.1111/1462-2920.13853⟩

Article dans une revue hal-01608428v1
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The Salmonella effector SteD Mediates MARCH8-dependent ubiquitination of MHC II molecules and inhibits T cell activation

Ethel Bayer-Santos , Charlotte H. Durkin , Luciano A. Rigano , Andreas Kupz , Eric Alix et al.

Cell Host and Microbe, 2016, 20 (5), pp.584-595. ⟨10.1016/j.chom.2016.10.007⟩

Article dans une revue hal-01606854v1
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Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice

Thomas W Hoffmann , Hang-Phuong Pham , Chantal Bridonneau , Camille Aubry , Bruno Lamas et al.

The International Society of Microbiologial Ecology Journal, 2016, 10 (2), pp.460-477. ⟨10.1038/ismej.2015.127⟩

Article dans une revue hal-01303788v1
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Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice

Elsa Jacouton , Núria Mach , Julie Cadiou , Nicolas Lapaque , Karine Clément et al.

PLoS ONE, 2015, 10 (10), pp.e0138880. ⟨10.1371/journal.pone.0138880⟩

Article dans une revue hal-01272988v1
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Commensal [i]Streptococcus salivarius[/i] modulates PPARγ transcriptional activity in human intestinal epithelial cells

Benoit Couvigny , Tomas de Wouters , Ghalia Kaci , Elsa Jacouton , Christine Delorme et al.

PLoS ONE, 2015, 10 (5), ⟨10.1371/journal.pone.0125371⟩

Article dans une revue hal-01204466v1
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Metagenomics of the human intestinal tract: from who is there to what is done there

Antonietta Cultrone , Julien Tap , Nicolas Lapaque , Joël Doré , Herve H. Blottiere

Current Opinion in Food Science, 2015, 4, pp.64-68. ⟨10.1016/j.cofs.2015.05.011⟩

Article dans une revue hal-02632823v1
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A robust and adaptable high throughput screening method to study host-microbiota interactions in the human intestine

Tomas de Wouters , Florence Ledue , Malgorzata Nepelska , Joel Dore , Herve Blottiere et al.

PLoS ONE, 2014, 9 (8), ⟨10.1371/journal.pone.0105598⟩

Article dans une revue hal-01204452v1
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ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways

Agata A. Korecka , Tomas T. de Wouters , Antonietta A. Cultrone , Nicolas N. Lapaque , Sven S. Pettersson et al.

AJP - Gastrointestinal and Liver Physiology, 2013, 304 (11), pp.G1025 - G1037. ⟨10.1152/ajpgi.00293.2012⟩

Article dans une revue hal-01001518v1

The NF-kappa B binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells

Antonietta A. Cultrone , Tomas T. de Wouters , Omar O. Lakhdari , Denise D. Kelly , Imke I. Mulder et al.

European Journal of Immunology, 2013, 43 (4), pp.1053 - 1062. ⟨10.1002/eji.201142340⟩

Article dans une revue hal-01001083v1
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Enterococcus faecalis prophage dynamics and contributions to pathogenic traits

Renata Filipa Cruz de Matos , Nicolas Lapaque , Lionel Rigottier-Gois , Laurent Debarbieux , Thierry Meylheuc et al.

PLoS Genetics, 2013, 9 (6), ⟨10.1371/journal.pgen.1003539⟩

Article dans une revue hal-01190746v1

HLA Class I Allelic Sequence and Conformation Regulate Leukocyte Ig-Like Receptor Binding

Des C. Jones , Vasilis Kosmoliaptsis , Richard Apps , Nicolas Lapaque , Isobel Smith et al.

Journal of Immunology, 2011, 186 (5), pp.2990 - 2997. ⟨10.4049/jimmunol.1003078⟩

Article dans une revue hal-01190489v1

Interactions between human NK cells and macrophages in response to Salmonella infection.

Nicolas Lapaque , Thierry Walzer , Stéphane Méresse , Eric Vivier , John Trowsdale

Journal of Immunology, 2009, 182 (7), pp.4339-48. ⟨10.4049/jimmunol.0803329⟩

Article dans une revue hal-00380263v1

Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9.

Nicolas Lapaque , Alexandre Muller , Lena Alexopoulou , Jonathan C Howard , Jean-Pierre Gorvel

Microbial Pathogenesis, 2009, epub ahead of print. ⟨10.1016/j.micpath.2009.09.005⟩

Article dans une revue istex hal-00431861v1
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Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1

Suzana P Salcedo , María Ines Marchesini , Hugues Lelouard , Emilie Fugier , Gilles Jolly et al.

PLoS Pathogens, 2008, 4 (2), pp.e21. ⟨10.1371/journal.ppat.0040021⟩

Article dans une revue hal-00294210v1

Brucella lipopolysaccharide acts as a virulence factor.

Nicolas Lapaque , Ignacio Moriyon , Edgardo Moreno , Jean-Pierre Gorvel

Current Opinion in Microbiology, 2005, 8 (1), pp.60-6. ⟨10.1016/j.mib.2004.12.003⟩

Article dans une revue istex hal-00165710v1

Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival.

Beatriz Arellano-Reynoso , Nicolas Lapaque , Susana Salcedo , Gabriel Briones , Andrés Eduardo Ciocchini et al.

Nature Immunology, 2005, 6 (6), pp.618-25. ⟨10.1038/ni1202⟩

Article dans une revue istex hal-00165692v1