NT

Nicolas Tchitchek

90 %
Libre accès
78
Documents
Affiliation actuelle
  • Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3)
Contact

Présentation

Ma recherche se concentre sur la caractérisation des dysrégulations moléculaires, cellulaires et microbiennes dans les troubles auto-immuns et auto-inflammatoires, à la fois en état stable et en réponse aux immunothérapies, en utilisant des approches d'immunologie systémique.

Publications

10
5
5
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
2
8
6
9
14
8
7
5
2
4
4
3
3
1
20
12
12
10
9
9
9
8
8
7
7
7
7
7
6
6
6
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2

Publications

Low-dose interleukin-2 in patients with bipolar depression: A phase 2 randomised double-blind placebo-controlled trial

Marion Leboyer , Marianne Foiselle , Nicolas Tchitchek , Ryad Tamouza , Roberta Lorenzon et al.

Brain, Behavior, and Immunity, 2025, 123, pp.177-184. ⟨10.1016/j.bbi.2024.09.005⟩

Article dans une revue hal-05472377v1
Deposit thumbnail

Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Nicolas Tchitchek , Marie Binvignat , Alexandra Roux , Fabien Pitoiset , Johanna Dubois et al.

Annals of the Rheumatic Diseases, 2024, ⟨10.1136/ard-2023-225179⟩

Article dans une revue hal-04490369v1

A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing–remitting multiple sclerosis

C Louapre , M Rosenzwajg , M Golse , A Roux , F Pitoiset et al.

Journal of Neurology, 2023, 270, pp.4403 - 4414. ⟨10.1007/s00415-023-11690-6⟩

Article dans une revue hal-04490382v1

Early systemic inflammation induces neurodevelopmental disorders: results from ARTEMIS, a French multicenter study of juvenile rheumatisms and systemic autoimmune and auto-inflammatory disorders and meta-analysis

Pierre Ellul , Isabelle Melki , Stephanie Antoun , Laura Lavialle , Eric Acquaviva et al.

Molecular Psychiatry, 2023, ⟨10.1038/s41380-023-01980-w⟩

Article dans une revue hal-03985785v1
Deposit thumbnail

Naive and memory CD4 + T cell subsets can contribute to the generation of human Tfh cells

Raphaël Jeger-Madiot , Romain Vaineau , Maud Heredia , Nicolas Tchitchek , Lisa Bertrand et al.

iScience, 2022, 25 (1), pp.103566. ⟨10.1016/j.isci.2021.103566⟩

Article dans une revue hal-03854774v2

Long‐term outcome of paediatric <scp>anti‐<i>N</i>‐methyl‐D</scp><scp>‐</scp>aspartate receptor encephalitis

Lorraine Flet‐berliac , Nicolas Tchitchek , Anne Lépine , Anca Florea , Hélène Maurey et al.

Developmental Medicine and Child Neurology - Developmental Medicine & Child Neurology, 2022, 65, pp.691 - 700. ⟨10.1111/dmcn.15429⟩

Article dans une revue hal-04490426v1
Deposit thumbnail

The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

Yanis Feraoun , Jean-Louis Palgen , Candie Joly , Nicolas Tchitchek , Ernesto Marcos-Lopez et al.

Frontiers in Immunology, 2022, 12, pp.784813. ⟨10.3389/fimmu.2021.784813⟩

Article dans une revue hal-03787905v1

Long-term outcome of paediatric anti-N-methyl-D-aspartate receptor encephalitis.

Lorraine Flet-Berliac , Nicolas Tchitchek , Anne Lépine , Anca Florea , Hélène Maurey et al.

Developmental Medicine and Child Neurology - Developmental Medicine & Child Neurology, 2022, ⟨10.1111/dmcn.15429⟩

Article dans une revue hal-03960996v1
Deposit thumbnail

The Tsallis generalized entropy enhances the interpretation of transcriptomics datasets

Nicolas Dérian , Hang-Phuong Pham , Djamel Nehar-Belaid , Nicolas Tchitchek , David Klatzmann et al.

PLoS ONE, 2022, 17 (4), pp.e0266618. ⟨10.1371/journal.pone.0266618⟩

Article dans une revue hal-03854768v1
Deposit thumbnail

Identification of Symptoms Phenotypes of Hand Osteoarthritis using Hierarchical Clustering: Results from the <scp>DIGICOD</scp> Cohort

Marie Binvignat , Gabriel Pires , Nicolas Tchitchek , Félicie Costantino , Alice Courties et al.

Arthritis Care & Research = Arthritis Care and Research, In press, ⟨10.1002/acr.25047⟩

Article dans une revue hal-03843031v1
Deposit thumbnail

Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation

Nicolas Tchitchek , Otriv Nguekap Tchoumba , Gabriel Pires , Sarah Dandou , Julien Campagne et al.

JCI Insight, 2022, 7 (17), ⟨10.1172/jci.insight.159406⟩

Article dans une revue hal-03797609v1
Deposit thumbnail

Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial

Antoine Monsel , Caroline Hauw-Berlemont , Miryam Mebarki , Nicholas Heming , Julien Mayaux et al.

Critical Care, 2022, 26 (1), ⟨10.1186/s13054-022-03930-4⟩

Article dans une revue hal-03604084v1
Deposit thumbnail

Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections

Nicolas Huot , Philippe Rascle , Nicolas Tchitchek , Benedikt Wimmer , Caroline Passaes et al.

iScience, 2021, 24 (4), pp.102314. ⟨10.1016/j.isci.2021.102314⟩

Article dans une revue hal-03225293v1
Deposit thumbnail

Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , André Rodriguez Pozo , Lev Stimmer et al.

Frontiers in Immunology, 2021, 12, pp.645210. ⟨10.3389/fimmu.2021.645210⟩

Article dans une revue hal-03321921v1
Deposit thumbnail

Predictive Markers of Immunogenicity and Efficacy for Human Vaccines

Matthieu van Tilbeurgh , Katia Lemdani , Anne-Sophie Beignon , Catherine Chapon , Nicolas Tchitchek et al.

Vaccines, 2021, 9 (6), pp.579. ⟨10.3390/vaccines9060579⟩

Article dans une revue hal-03278510v1
Deposit thumbnail

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Erminia Rubino , Melania Cruciani , Nicolas Tchitchek , Anna Le Tortorec , Antoine Rolland et al.

Frontiers in Genetics, 2021, 11, ⟨10.3389/fgene.2020.627007⟩

Article dans une revue hal-03154598v1
Deposit thumbnail

Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants

Mariangela Cavarelli , Stéphane Hua , Naima Hantour , Sabine Tricot , Nicolas Tchitchek et al.

Communications Biology, 2021, 4, pp.861. ⟨10.1038/s42003-021-02383-9⟩

Article dans une revue hal-03287057v1

Bacnet: a user-friendly platform for building multi-omics websites.

Loane Danès , Nicolas Tchitchek , Christophe Bécavin

Bioinformatics (Oxford, England), 2021, 37 (9), pp.1335--1336. ⟨10.1093/bioinformatics/btaa828⟩

Article dans une revue hal-03961011v1

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination

Lucille Adam , Nicolas Tchitchek , Biliana Todorova , Pierre Rosenbaum , Candie Joly et al.

Journal of Immunology, 2020, 204 (12), pp.3375-3388. ⟨10.4049/jimmunol.1900517⟩

Article dans une revue hal-03984525v1
Deposit thumbnail

DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

Simon P. Jochems , Beatrice Jacquelin , Nicolas Tchitchek , Florence Busato , Fabien Pichon et al.

Clinical Epigenetics, 2020, 12 (1), pp.188. ⟨10.1186/s13148-020-00971-w⟩

Article dans une revue hal-03225306v1
Deposit thumbnail

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses After Electroporated DNA Vaccination

Lucille Adam , Nicolas Tchitchek , Biliana Todorova , Pierre Rosenbaum , Candie Joly et al.

Journal of Immunology, 2020, 204 (12), pp.3375-3388. ⟨10.4049/jimmunol.1900517⟩

Article dans une revue inserm-02869578v1
Deposit thumbnail

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations

Jean-Louis Palgen , Nicolas Tchitchek , André Rodriguez-Pozo , Quentin Jouhault , Hadjer Abdelhouahab et al.

NPJ vaccines, 2020, 5, ⟨10.1038/s41541-020-0175-8⟩

Article dans une revue hal-03079492v1
Deposit thumbnail

Mechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine

Jessica Gonnet , Lauranne Poncelet , Celine Meriaux , Elena Gonçalves , Lina Weiss et al.

Journal of Proteomics, 2020, 216, pp.103670. ⟨10.1016/j.jprot.2020.103670⟩

Article dans une revue hal-03984601v2
Deposit thumbnail

Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals

Adrien Leite Pereira , Quentin Jouhault , Ernesto Marcos Lopez , Antonio Cosma , Olivier Lambotte et al.

Frontiers in Immunology, 2020, 11 (6), pp.579. ⟨10.3389/fimmu.2020.02096⟩

Article dans une revue hal-03960814v1
Deposit thumbnail

Salivary gland epithelial cells from patients with Sjögren's syndrome induce B-lymphocyte survival and activation

Elodie Riviere , Juliette Pascaud , Nicolas Tchitchek , Saida Boudaoud , Audrey Paoletti et al.

Annals of the Rheumatic Diseases, 2020, 79 (11), pp.1468-1477. ⟨10.1136/annrheumdis-2019-216588⟩

Article dans une revue inserm-03150054v1
Deposit thumbnail

Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study

Michelle Rosenzwajg , Randa Salet , Roberta Lorenzon , Nicolas Tchitchek , Alexandra Roux et al.

Diabetologia, 2020, 63 (9), pp.1808-1821. ⟨10.1007/s00125-020-05200-w⟩

Article dans une revue hal-03345047v1
Deposit thumbnail

Interleukin‐7/Interferon axis drives T‐cell and salivary gland epithelial cell interactions in Sjögren’s syndrome

Elodie Rivière , Juliette Pascaud , Alexandre Virone , Anastasia Dupré , Bineta Ly et al.

Arthritis & rheumatology, 2020, 73 (4), pp.631-640. ⟨10.1002/art.41558⟩

Article dans une revue pasteur-03036519v1
Deposit thumbnail

Characterization of Leukocytes From HIV-ART Patients Using Combined Cytometric Profiles of 72 Cell Markers.

Adrien Leite Pereira , Nicolas Tchitchek , Olivier Lambotte , Roger Le Grand , Antonio Cosma

Frontiers in Immunology, 2019, 10, pp.1777. ⟨10.3389/fimmu.2019.01777⟩

Article dans une revue hal-03961014v1
Deposit thumbnail

CytoBackBone: an algorithm for merging of phenotypic information from different cytometric profiles.

Adrien Leite Pereira , Olivier Lambotte , Roger Le Grand , Antonio Cosma , Nicolas Tchitchek

Bioinformatics, 2019, 35 (20), pp.4187-4189. ⟨10.1093/bioinformatics/btz212⟩

Article dans une revue hal-03961015v1
Deposit thumbnail

Early blood transcriptomic signature predicts patients’ outcome after out-of-hospital cardiac arrest

Renaud Tissier , Hakim Hocini , Nicolas Tchitchek , Nicolas Deye , Stéphane Legriel et al.

Resuscitation, 2019, 138, pp.222 - 232. ⟨10.1016/j.resuscitation.2019.03.006⟩

Article dans une revue hal-03485659v1
Deposit thumbnail

Characterization of Phenotypes and Functional Activities of Leukocytes From Rheumatoid Arthritis Patients by Mass Cytometry.

Adrien Leite Pereira , Samuel Bitoun , Audrey Paoletti , Gaetane Nocturne , Ernesto Marcos Lopez et al.

Frontiers in Immunology, 2019, 10, pp.2384. ⟨10.3389/fimmu.2019.02384⟩

Article dans une revue hal-03961013v1
Deposit thumbnail

Cynomolgus macaque IL37 polymorphism and control of SIV infection

Takashi Shiina , Shingo Suzuki , Nicolas Congy-Jolivet , Alice Aarnink , Henri-Jean Garchon et al.

Scientific Reports, 2019, 9 (1), pp.7981. ⟨10.1038/s41598-019-44235-x⟩

Article dans une revue hal-02149363v1
Deposit thumbnail

Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques

Marie-Thérèse Nugeyre , Nicolas Tchitchek , Cindy Adapen , Claude Cannou , Vanessa Contreras et al.

Frontiers in Cellular and Infection Microbiology, 2019, 9, pp.188. ⟨10.3389/fcimb.2019.00188⟩

Article dans une revue inserm-02433779v1

Progenitors from the central nervous system drive neurogenesis in cancer

Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Alexis-Pierre Bemelmans , Virginie Firlej et al.

Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩

Article dans une revue hal-03987060v1

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Elena Gonçalves , Olivia Bonduelle , Angèle Soria , Pierre Loulergue , Alexandra Rousseau et al.

The Journal of clinical investigation, 2019, 129 (5), pp.1960-1971. ⟨10.1172/jci125372⟩

Article dans une revue hal-03160706v1
Deposit thumbnail

NK cell immune responses differ after prime and boost vaccination

Jean‐louis Palgen , Nicolas Tchitchek , Nicolas Huot , Jamila Elhmouzi-Younes , Cécile Lefebvre et al.

Journal of Leukocyte Biology, 2019, 105 (5), pp.1055-1073. ⟨10.1002/JLB.4A1018-391RR⟩

Article dans une revue hal-02385954v1
Deposit thumbnail

Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection

Sixtine Coindre , Nicolas Tchitchek , Lamine Alaoui , Bruno Vaslin , Christine Bourgeois et al.

Frontiers in Immunology, 2019, ⟨10.3389/fimmu.2019.02677⟩

Article dans une revue hal-02386129v1
Deposit thumbnail

Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques

Claire-Maëlle Fovet , Lev Stimmer , Vanessa Contreras , Philippe Horellou , Audrey Hubert et al.

EBioMedicine, 2019, 47, pp.492-505. ⟨10.1016/j.ebiom.2019.08.052⟩

Article dans une revue hal-02305565v1
Deposit thumbnail

Progenitors from the central nervous system drive neurogenesis in cancer

Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Alexis-Pierre Bemelmans , Virginie Firlej et al.

Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩

Article dans une revue cea-02186559v1
Deposit thumbnail

Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae

Romain Marlin , Marie-Thérèse Nugeyre , Nicolas Tchitchek , Matteo Parenti , Cécile Lefebvre et al.

Frontiers in Immunology, 2019, 10, pp.430. ⟨10.3389/fimmu.2019.00430⟩

Article dans une revue inserm-02433796v1
Deposit thumbnail

Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

Che Serguera , Lev Stimmer , Claire-Maëlle Fovet , Philippe Horellou , Vanessa Contreras et al.

Journal of Neuroinflammation, 2019, 16, pp.244. ⟨10.1186/s12974-019-1637-7⟩

Article dans une revue cea-02397764v1

Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Jean-Louis Palgen , Nicolas Tchitchek , Jamila Elhmouzi-Younes , Simon Delandre , Inana Namet et al.

Scientific Reports, 2018, 8 (1), pp.3087. ⟨10.1038/s41598-018-21222-2⟩

Article dans une revue hal-03984523v1

Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , Lev Stimmer , Hakim Hocini et al.

Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.00870⟩

Article dans une revue hal-03984590v1

Navigating in the vast and deep oceans of high-dimensional biological data.

Nicolas Tchitchek

Methods (San Diego, Calif.), 2018, 132, pp.1--2. ⟨10.1016/j.ymeth.2017.11.009⟩

Article dans une revue hal-03961017v1
Deposit thumbnail

Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection

Nadia Echebli , Nicolas Tchitchek , Stéphanie Dupuy , Timothée Bruel , Caroline Passaes et al.

PLoS ONE, 2018, 13 (1), pp.e0190334. ⟨10.1371/journal.pone.0190334⟩

Article dans une revue hal-02861901v1
Deposit thumbnail

A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans

Adrien Leite Pereira , Nicolas Tchitchek , Ernesto Marcos Lopez , Olivier Lambotte , Roger Le Grand et al.

Cytokine, 2018, 111, pp.97 - 105. ⟨10.1016/j.cyto.2018.08.018⟩

Article dans une revue hal-03854788v1
Deposit thumbnail

Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Jean-Louis Palgen , Nicolas Tchitchek , Jamila Elhmouzi-Younes , Simon Delandre , Inana Namet et al.

Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-21222-2⟩

Article dans une revue hal-02385941v1
Deposit thumbnail

Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART

Sixtine Coindre , Nicolas Tchitchek , Lamine Alaoui , Bruno Vaslin , Christine Bourgeois et al.

Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.01217⟩

Article dans une revue hal-02386113v1
Deposit thumbnail

Molecular and cellular Dynamics in the skin, the lymph nodes, and the Blood of the immune response to intradermal injection of Modified Vaccinia ankara Vaccine

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , Lev Stimmer , Hakim Hocini et al.

Frontiers in Immunology, 2018, 9, pp.870. ⟨10.3389/fimmu.2018.00870⟩

Article dans une revue hal-02386077v1
Deposit thumbnail

Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry

Romain Marlin , Marie-Thérèse Nugeyre , Nicolas Tchitchek , Matteo Parenti , Hakim Hocini et al.

Journal of Immunology, 2017, 199 (5), pp.1923 - 1932. ⟨10.4049/jimmunol.1700320⟩

Article dans une revue pasteur-01597708v1

In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry.

Jamila Elhmouzi-Younes , Jean-Louis Palgen , Nicolas Tchitchek , Simon Delandre , Inana Namet et al.

Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2017, 91 (10), pp.969--982. ⟨10.1002/cyto.a.23107⟩

Article dans une revue hal-03961018v1
Deposit thumbnail

A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data

Ludovic Platon , David Pejoski , Guillaume Gautreau , Brice Targat , Roger Le Grand et al. Article dans une revue hal-02386051v1

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus.

Pierre Roques , Karl Ljungberg , Beate M. Kümmerer , Leslie Gosse , Nathalie Dereuddre-Bosquet et al.

JCI Insight, 2017, 2 (6), pp.e83527. ⟨10.1172/jci.insight.83527⟩

Article dans une revue hal-03961019v1
Deposit thumbnail

Listeriomics : an Interactive Web Platform for Systems Biology of Listeria

Christophe Bécavin , Mikael Koutero , Nicolas Tchitchek , Franck Cerutti , Pierre Lechat et al.

mSystems, 2017, 2 (2), pp.e00186-16. ⟨10.1128/mSystems.00186-16⟩

Article dans une revue pasteur-01574970v1
Deposit thumbnail

SPADEVizR: an R package for Visualization, Analysis and Integration of SPADE results

Guillaume Gautreau , David Pejoski , Roger Le Grand , Antonio Cosma , Anne-Sophie Beignon et al.

Bioinformatics, 2017, pp.btw708. ⟨10.1093/bioinformatics/btw708⟩

Article dans une revue hal-02385937v1
Deposit thumbnail

Analysis methodology and development of a statistical tool for biodistribution data from internal contamination with actinides

Stephanie Lamart , Nina Griffiths , Nicolas Tchitchek , Jaime Angulo , Anne van der Meeren

Journal of Radiological Protection, 2017, 37 (1), pp.296-308. ⟨10.1088/1361-6498/37/1/296⟩

Article dans une revue hal-03856452v1

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta et al.

Journal of Virology, 2016, 90, pp.2240 - 2253. ⟨10.1128/jvi.02974-15⟩

Article dans une revue hal-04493263v1

Identification of Vaccine-Altered Circulating B Cell Phenotypes Using Mass Cytometry and a Two-Step Clustering Analysis.

David Pejoski , Nicolas Tchitchek , André Rodriguez Pozo , Jamila Elhmouzi-Younes , Rahima Yousfi-Bogniaho et al.

Journal of immunology (Baltimore, Md. : 1950), 2016, 196 (11), pp.4814--4831. ⟨10.4049/jimmunol.1502005⟩

Article dans une revue hal-03961021v1
Deposit thumbnail

The 1918 influenza virus PB2 protein enhances virulence through the disruption of inflammatory and Wnt-mediated signaling in mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta et al.

Journal of Virology, 2016, 90 (5), pp.2240-2253. ⟨10.1128/JVI.02974-15⟩

Article dans une revue hal-03851553v1

Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study

Diane Bodez , Hakim Hocini , Nicolas Tchitchek , Pascaline Tisserand , Nicole Benhaiem et al.

PLoS ONE, 2016, 11 (11), pp.e0167213. ⟨10.1371/journal.pone.0167213⟩

Article dans une revue hal-03987039v1

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta et al.

Journal of Virology, 2016, 90, pp.2240 - 2253. ⟨10.1128/jvi.02974-15⟩

Article dans une revue hal-04493274v1
Deposit thumbnail

Delayed Inflammatory and Cell Death Responses Are Associated with Reduced Pathogenicity in Lujo Virus-Infected Cynomolgus Macaques

Angela L Rasmussen , Nicolas Tchitchek , David Safronetz , Victoria S Carter , Christopher M Williams et al.

Journal of Virology, 2015, 89 (5), pp.2543 - 2552. ⟨10.1128/jvi.02246-14⟩

Article dans une revue hal-03851569v1
Deposit thumbnail

Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria.

Fabien Herbert , Nicolas Tchitchek , Devendra Bansal , Julien Jacques , Sulabha Pathak et al.

Journal of Translational Medicine, 2015, 13, pp.369. ⟨10.1186/s12967-015-0731-6⟩

Article dans une revue hal-02051283v1

Sequencing, annotation and analysis of the Syrian hamster (Mesocricetus auratus) transcriptome.

Nicolas Tchitchek , David Safronetz , Angela L. Rasmussen , Craig Martens , Kimmo Virtaneva et al.

PLoS ONE, 2014, 9 (11), pp.e112617. ⟨10.1371/journal.pone.0112617⟩

Article dans une revue hal-03961022v1

A comprehensive collection of systems biology data characterizing the host response to viral infection.

Brian D. Aevermann , Brett E. Pickett , Sanjeev Kumar , Edward B. Klem , Sudhakar Agnihothram et al.

Scientific Data, 2014, 1, pp.140033. ⟨10.1038/sdata.2014.33⟩

Article dans une revue hal-03961036v1

H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice.

Juliet Morrison , Laurence Josset , Nicolas Tchitchek , Jean Chang , Jessica A. Belser et al.

Journal of virology, 2014, 88 (18), pp.10556--10568. ⟨10.1128/JVI.00570-14⟩

Article dans une revue hal-03961023v1

Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts.

Laurence Josset , Nicolas Tchitchek , Lisa E. Gralinski , Martin T. Ferris , Amie J. Eisfeld et al.

RNA Biology, 2014, 11 (7), pp.875--890. ⟨10.4161/rna.29442⟩

Article dans une revue hal-03961024v1
Deposit thumbnail

Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice

Nicolas Tchitchek , Amie Eisfeld , Jennifer Tisoncik-Go , Laurence Josset , Lisa Gralinski et al.

BMC Systems Biology, 2013, 7 (1), pp.69. ⟨10.1186/1752-0509-7-69⟩

Article dans une revue pasteur-00850969v1

Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.

Marcus J. Korth , Nicolas Tchitchek , Arndt G. Benecke , Michael G. Katze

Seminars in immunology, 2013, 25 (3), pp.228--239. ⟨10.1016/j.smim.2012.11.001⟩

Article dans une revue hal-03961025v1
Deposit thumbnail

A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses

Hugh D. Mitchell , Amie J. Eisfeld , Amy C. Sims , Jason E. Mcdermott , Melissa M. Matzke et al.

PLoS ONE, 2013, 8 (7), pp.e69374. ⟨10.1371/journal.pone.0069374⟩

Article dans une revue hal-01543316v1
Deposit thumbnail

1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice

Tokiko Watanabe , Jennifer Tisoncik-Go , Nicolas Tchitchek , Shinji Watanabe , Arndt G. Benecke et al.

Journal of Virology, 2013, 87 (9), pp.5239-5254. ⟨10.1128/JVI.02753-12⟩

Article dans une revue hal-01543311v1
Deposit thumbnail

2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

Jennifer Go , Sarah Belisle , Nicolas Tchitchek , Terrence Tumpey , Wenjun Ma et al.

BMC Genomics, 2012, 13 (1), pp.627. ⟨10.1186/1471-2164-13-627⟩

Article dans une revue hal-03849383v1
Deposit thumbnail

Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus.

Nicolas Tchitchek , Béatrice Jacquelin , Patrick Wincker , Carole Dossat , Corinne Da Silva et al.

BMC Genomics, 2012, 13 (1), pp.279. ⟨10.1186/1471-2164-13-279⟩

Article dans une revue inserm-00771549v1
Deposit thumbnail

CDS: A Fold-change Based Statistical Test for Concomitant Identification of Distinctness and Similarity in Gene Expression Analysis

Nicolas Tchitchek , José Felipe Golib Dzib , Brice Targat , Sebastian Noth , Arndt Benecke et al.

Genomics, Proteomics and Bioinformatics, 2012, 10 (3), pp.127-135. ⟨10.1016/j.gpb.2012.06.002⟩

Article dans une revue hal-01544156v1

Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1.

Fábio L. Fernandes-Rosa , Edwige-Ludiwyne Hubert , Jérome Fagart , Nicolas Tchitchek , Debora Gomes et al.

Journal of Clinical Endocrinology and Metabolism, 2011, 96 (3), pp.E519--527. ⟨10.1210/jc.2010-1486⟩

Article dans une revue hal-03961027v1
Deposit thumbnail

A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections

Stewart Chang , Nicolas Tchitchek , Debashis Ghosh , Arndt Benecke , Michael Katze

BMC Systems Biology, 2011, 5 (1), pp.202. ⟨10.1186/1752-0509-5-202⟩

Article dans une revue hal-03849356v1

Improving the efficiency of multidimensional scaling in the analysis of high-dimensional data using singular value decomposition.

Christophe Bécavin , Nicolas Tchitchek , Colette Mintsa-Eya , Annick Lesne , Arndt Benecke

Bioinformatics (Oxford, England), 2011, 27 (10), pp.1413--1421. ⟨10.1093/bioinformatics/btr143⟩

Article dans une revue hal-03961026v1
Deposit thumbnail

The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea.

Kathrin Endt , Bärbel Stecher , Samuel Chaffron , Emma Slack , Nicolas Tchitchek et al.

PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩

Article dans une revue inserm-00520162v1