Access content directly
NT

Nicolas Tchitchek

87%
Open access
78
Documents
Current affiliations
  • 542085
Researcher identifiers
Contact

Presentation

My research focuses on the characterization of molecular, cellular, and microbial dysregulations in autoimmune and autoinflammatory disorders, at both steady state and in response to immunotherapies, using systems immunology approaches.
Ma recherche se concentre sur la caractérisation des dysrégulations moléculaires, cellulaires et microbiennes dans les troubles auto-immuns et auto-inflammatoires, à la fois en état stable et en réponse aux immunothérapies, en utilisant des approches d'immunologie systémique.

Publications

Image document

Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Nicolas Tchitchek , Marie Binvignat , Alexandra Roux , Fabien Pitoiset , Johanna Dubois
Annals of the Rheumatic Diseases, 2024, ⟨10.1136/ard-2023-225179⟩
Journal articles hal-04490369v1

A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing–remitting multiple sclerosis

C. Louapre , M. Rosenzwajg , M. Golse , A. Roux , F. Pitoiset
Journal of Neurology, 2023, 270 (9), pp.4403-4414. ⟨10.1007/s00415-023-11690-6⟩
Journal articles hal-04493282v1

Early systemic inflammation induces neurodevelopmental disorders: results from ARTEMIS, a French multicenter study of juvenile rheumatisms and systemic autoimmune and auto-inflammatory disorders and meta-analysis

Pierre Ellul , Isabelle Melki , Stephanie Antoun , Laura Lavialle , Eric Acquaviva
Molecular Psychiatry, 2023, ⟨10.1038/s41380-023-01980-w⟩
Journal articles hal-03985785v1

A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing–remitting multiple sclerosis

C Louapre , M Rosenzwajg , M Golse , A Roux , F Pitoiset
Journal of Neurology, 2023, 270, pp.4403 - 4414. ⟨10.1007/s00415-023-11690-6⟩
Journal articles hal-04490382v1

Long‐term outcome of paediatric anti‐N‐methyl‐Daspartate receptor encephalitis

Lorraine Flet‐berliac , Nicolas Tchitchek , Anne Lépine , Anca Florea , Hélène Maurey
Developmental Medicine and Child Neurology, 2022, 65, pp.691 - 700. ⟨10.1111/dmcn.15429⟩
Journal articles hal-04490426v1

Long-term outcome of paediatric anti-N-methyl-D-aspartate receptor encephalitis.

Lorraine Flet-Berliac , Nicolas Tchitchek , Anne Lépine , Anca Florea , Hélène Maurey
Developmental medicine and child neurology, 2022, ⟨10.1111/dmcn.15429⟩
Journal articles hal-03960996v1
Image document

The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

Yanis Feraoun , Jean-Louis Palgen , Candie Joly , Nicolas Tchitchek , Ernesto Marcos-Lopez
Frontiers in Immunology, 2022, 12, pp.784813. ⟨10.3389/fimmu.2021.784813⟩
Journal articles hal-03787905v1
Image document

Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation

Nicolas Tchitchek , Otriv Nguekap Tchoumba , Gabriel Pires , Sarah Dandou , Julien Campagne
JCI Insight, 2022, 7 (17), ⟨10.1172/jci.insight.159406⟩
Journal articles hal-03797609v1
Image document

The Tsallis generalized entropy enhances the interpretation of transcriptomics datasets

Nicolas Dérian , Hang-Phuong Pham , Djamel Nehar-Belaid , Nicolas Tchitchek , David Klatzmann
PLoS ONE, 2022, 17 (4), pp.e0266618. ⟨10.1371/journal.pone.0266618⟩
Journal articles hal-03854768v1
Image document

Identification of Symptoms Phenotypes of Hand Osteoarthritis using Hierarchical Clustering: Results from the DIGICOD Cohort

Marie Binvignat , Gabriel Pires , Nicolas Tchitchek , Félicie Costantino , Alice Courties
Arthritis Care & Research = Arthritis Care and Research, inPress, ⟨10.1002/acr.25047⟩
Journal articles hal-03843031v1
Image document

Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial

Antoine Monsel , Caroline Hauw-Berlemont , Miryam Mebarki , Nicholas Heming , Julien Mayaux
Critical Care, 2022, 26 (1), ⟨10.1186/s13054-022-03930-4⟩
Journal articles hal-03604084v1
Image document

Naive and memory CD4 + T cell subsets can contribute to the generation of human Tfh cells

Raphaël Jeger-Madiot , Romain Vaineau , Maud Heredia , Nicolas Tchitchek , Lisa Bertrand
iScience, 2022, 25 (1), pp.103566. ⟨10.1016/j.isci.2021.103566⟩
Journal articles hal-03854774v2
Image document

Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections

Nicolas Huot , Philippe Rascle , Nicolas Tchitchek , Benedikt Wimmer , Caroline Passaes
iScience, 2021, 24 (4), pp.102314. ⟨10.1016/j.isci.2021.102314⟩
Journal articles hal-03225293v1
Image document

Predictive Markers of Immunogenicity and Efficacy for Human Vaccines

Matthieu van Tilbeurgh , Katia Lemdani , Anne-Sophie Beignon , Catherine Chapon , Nicolas Tchitchek
Vaccines, 2021, 9 (6), pp.579. ⟨10.3390/vaccines9060579⟩
Journal articles hal-03278510v1
Image document

Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , André Rodriguez Pozo , Lev Stimmer
Frontiers in Immunology, 2021, 12, pp.645210. ⟨10.3389/fimmu.2021.645210⟩
Journal articles hal-03321921v1

Bacnet: a user-friendly platform for building multi-omics websites.

Loane Danès , Nicolas Tchitchek , Christophe Bécavin
Bioinformatics (Oxford, England), 2021, 37 (9), pp.1335--1336. ⟨10.1093/bioinformatics/btaa828⟩
Journal articles hal-03961011v1
Image document

Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants

Mariangela Cavarelli , Stéphane Hua , Naima Hantour , Sabine Tricot , Nicolas Tchitchek
Communications Biology, 2021, 4, pp.861. ⟨10.1038/s42003-021-02383-9⟩
Journal articles hal-03287057v1
Image document

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Erminia Rubino , Melania Cruciani , Nicolas Tchitchek , Anna Le Tortorec , Antoine Rolland
Frontiers in Genetics, 2021, 11, ⟨10.3389/fgene.2020.627007⟩
Journal articles hal-03154598v1

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination

Lucille Adam , Nicolas Tchitchek , Biliana Todorova , Pierre Rosenbaum , Candie Joly
Journal of Immunology, 2020, 204 (12), pp.3375-3388. ⟨10.4049/jimmunol.1900517⟩
Journal articles hal-03984525v1
Image document

DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

Simon P. Jochems , Beatrice Jacquelin , Nicolas Tchitchek , Florence Busato , Fabien Pichon
Clinical Epigenetics, 2020, 12 (1), pp.188. ⟨10.1186/s13148-020-00971-w⟩
Journal articles hal-03225306v1
Image document

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses After Electroporated DNA Vaccination

Lucille Adam , Nicolas Tchitchek , Biliana Todorova , Pierre Rosenbaum , Candie Joly
Journal of Immunology, 2020, 204 (12), pp.3375-3388. ⟨10.4049/jimmunol.1900517⟩
Journal articles inserm-02869578v1
Image document

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations

Jean-Louis Palgen , Nicolas Tchitchek , André Rodriguez-Pozo , Quentin Jouhault , Hadjer Abdelhouahab
NPJ vaccines, 2020, 5, ⟨10.1038/s41541-020-0175-8⟩
Journal articles hal-03079492v1
Image document

Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study

Michelle Rosenzwajg , Randa Salet , Roberta Lorenzon , Nicolas Tchitchek , Alexandra Roux
Diabetologia, 2020, 63 (9), pp.1808-1821. ⟨10.1007/s00125-020-05200-w⟩
Journal articles hal-03345047v1
Image document

Interleukin‐7/Interferon axis drives T‐cell and salivary gland epithelial cell interactions in Sjögren’s syndrome

Elodie Rivière , Juliette Pascaud , Alexandre Virone , Anastasia Dupré , Bineta Ly
Arthritis & rheumatology, 2020, 73 (4), pp.631-640. ⟨10.1002/art.41558⟩
Journal articles pasteur-03036519v1
Image document

Mechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine

Jessica Gonnet , Lauranne Poncelet , Celine Meriaux , Elena Gonçalves , Lina Weiss
Journal of Proteomics, 2020, 216, pp.103670. ⟨10.1016/j.jprot.2020.103670⟩
Journal articles hal-03984601v2
Image document

Salivary gland epithelial cells from patients with Sjögren's syndrome induce B-lymphocyte survival and activation

Elodie Riviere , Juliette Pascaud , Nicolas Tchitchek , Saida Boudaoud , Audrey Paoletti
Annals of the Rheumatic Diseases, 2020, 79 (11), pp.1468-1477. ⟨10.1136/annrheumdis-2019-216588⟩
Journal articles inserm-03150054v1
Image document

Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals

Adrien Leite Pereira , Quentin Jouhault , Ernesto Marcos Lopez , Antonio Cosma , Olivier Lambotte
Frontiers in Immunology, 2020, 11 (6), pp.579. ⟨10.3389/fimmu.2020.02096⟩
Journal articles hal-03960814v1
Image document

Characterization of Phenotypes and Functional Activities of Leukocytes From Rheumatoid Arthritis Patients by Mass Cytometry.

Adrien Leite Pereira , Samuel Bitoun , Audrey Paoletti , Gaetane Nocturne , Ernesto Marcos Lopez
Frontiers in Immunology, 2019, 10, pp.2384. ⟨10.3389/fimmu.2019.02384⟩
Journal articles hal-03961013v1
Image document

Cynomolgus macaque IL37 polymorphism and control of SIV infection

Takashi Shiina , Shingo Suzuki , Nicolas Congy-Jolivet , Alice Aarnink , Henri-Jean Garchon
Scientific Reports, 2019, 9 (1), pp.7981. ⟨10.1038/s41598-019-44235-x⟩
Journal articles hal-02149363v1

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Elena Gonçalves , Olivia Bonduelle , Angèle Soria , Pierre Loulergue , Alexandra Rousseau
The Journal of clinical investigation, 2019, 129 (5), pp.1960-1971. ⟨10.1172/jci125372⟩
Journal articles hal-03160706v1

Progenitors from the central nervous system drive neurogenesis in cancer

Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Alexis-Pierre Bemelmans , Virginie Firlej
Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩
Journal articles hal-03987060v1
Image document

Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques

Marie-Thérèse Nugeyre , Nicolas Tchitchek , Cindy Adapen , Claude Cannou , Vanessa Contreras
Frontiers in Cellular and Infection Microbiology, 2019, 9, pp.188. ⟨10.3389/fcimb.2019.00188⟩
Journal articles inserm-02433779v1
Image document

Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

Che Serguera , Lev Stimmer , Claire-Maëlle Fovet , Philippe Horellou , Vanessa Contreras
Journal of Neuroinflammation, 2019, 16, pp.244. ⟨10.1186/s12974-019-1637-7⟩
Journal articles cea-02397764v1
Image document

Characterization of Leukocytes From HIV-ART Patients Using Combined Cytometric Profiles of 72 Cell Markers.

Adrien Leite Pereira , Nicolas Tchitchek , Olivier Lambotte , Roger Le Grand , Antonio Cosma
Frontiers in Immunology, 2019, 10, pp.1777. ⟨10.3389/fimmu.2019.01777⟩
Journal articles hal-03961014v1
Image document

CytoBackBone: an algorithm for merging of phenotypic information from different cytometric profiles.

Adrien Leite Pereira , Olivier Lambotte , Roger Le Grand , Antonio Cosma , Nicolas Tchitchek
Bioinformatics, 2019, 35 (20), pp.4187-4189. ⟨10.1093/bioinformatics/btz212⟩
Journal articles hal-03961015v1
Image document

Early blood transcriptomic signature predicts patients’ outcome after out-of-hospital cardiac arrest

Renaud Tissier , Hakim Hocini , Nicolas Tchitchek , Nicolas Deye , Stéphane Legriel
Resuscitation, 2019, 138, pp.222 - 232. ⟨10.1016/j.resuscitation.2019.03.006⟩
Journal articles hal-03485659v1
Image document

NK cell immune responses differ after prime and boost vaccination

Jean‐louis Palgen , Nicolas Tchitchek , Nicolas Huot , Jamila Elhmouzi-Younes , Cécile Lefebvre
Journal of Leukocyte Biology, 2019, 105 (5), pp.1055-1073. ⟨10.1002/JLB.4A1018-391RR⟩
Journal articles hal-02385954v1
Image document

Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae

Romain Marlin , Marie-Thérèse Nugeyre , Nicolas Tchitchek , Matteo Parenti , Cécile Lefebvre
Frontiers in Immunology, 2019, 10, pp.430. ⟨10.3389/fimmu.2019.00430⟩
Journal articles inserm-02433796v1
Image document

Progenitors from the central nervous system drive neurogenesis in cancer

Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Alexis-Pierre Bemelmans , Virginie Firlej
Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩
Journal articles cea-02186559v1
Image document

Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection

Sixtine Coindre , Nicolas Tchitchek , Lamine Alaoui , Bruno Vaslin , Christine Bourgeois
Frontiers in Immunology, 2019, ⟨10.3389/fimmu.2019.02677⟩
Journal articles hal-02386129v1
Image document

Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques

Claire-Maëlle Fovet , Lev Stimmer , Vanessa Contreras , Philippe Horellou , Audrey Hubert
EBioMedicine, 2019, 47, pp.492-505. ⟨10.1016/j.ebiom.2019.08.052⟩
Journal articles hal-02305565v1

Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , Lev Stimmer , Hakim Hocini
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.00870⟩
Journal articles hal-03984590v1

Navigating in the vast and deep oceans of high-dimensional biological data.

Nicolas Tchitchek
Methods (San Diego, Calif.), 2018, 132, pp.1--2. ⟨10.1016/j.ymeth.2017.11.009⟩
Journal articles hal-03961017v1
Image document

Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection

Nadia Echebli , Nicolas Tchitchek , Stéphanie Dupuy , Timothée Bruel , Caroline Passaes
PLoS ONE, 2018, 13 (1), pp.e0190334. ⟨10.1371/journal.pone.0190334⟩
Journal articles pasteur-02861901v1
Image document

A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans

Adrien Leite Pereira , Nicolas Tchitchek , Ernesto Marcos Lopez , Olivier Lambotte , Roger Le Grand
Cytokine, 2018, 111, pp.97 - 105. ⟨10.1016/j.cyto.2018.08.018⟩
Journal articles hal-03854788v1
Image document

Molecular and cellular Dynamics in the skin, the lymph nodes, and the Blood of the immune response to intradermal injection of Modified Vaccinia ankara Vaccine

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , Lev Stimmer , Hakim Hocini
Frontiers in Immunology, 2018, 9, pp.870. ⟨10.3389/fimmu.2018.00870⟩
Journal articles hal-02386077v1
Image document

Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Jean-Louis Palgen , Nicolas Tchitchek , Jamila Elhmouzi-Younes , Simon Delandre , Inana Namet
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-21222-2⟩
Journal articles hal-02385941v1

Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Jean-Louis Palgen , Nicolas Tchitchek , Jamila Elhmouzi-Younes , Simon Delandre , Inana Namet
Scientific Reports, 2018, 8 (1), pp.3087. ⟨10.1038/s41598-018-21222-2⟩
Journal articles hal-03984523v1
Image document

Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART

Sixtine Coindre , Nicolas Tchitchek , Lamine Alaoui , Bruno Vaslin , Christine Bourgeois
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.01217⟩
Journal articles hal-02386113v1
Image document

SPADEVizR: an R package for Visualization, Analysis and Integration of SPADE results

Guillaume Gautreau , David Pejoski , Roger Le Grand , Antonio Cosma , Anne-Sophie Beignon
Bioinformatics, 2017, pp.btw708. ⟨10.1093/bioinformatics/btw708⟩
Journal articles hal-02385937v1
Image document

Listeriomics : an Interactive Web Platform for Systems Biology of Listeria

Christophe Bécavin , Mikael Koutero , Nicolas Tchitchek , Franck Cerutti , Pierre Lechat
mSystems, 2017, 2 (2), pp.e00186-16. ⟨10.1128/mSystems.00186-16⟩
Journal articles pasteur-01574970v1

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus.

Pierre Roques , Karl Ljungberg , Beate M. Kümmerer , Leslie Gosse , Nathalie Dereuddre-Bosquet
JCI Insight, 2017, 2 (6), pp.e83527. ⟨10.1172/jci.insight.83527⟩
Journal articles hal-03961019v1
Image document

A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data

Ludovic Platon , David Pejoski , Guillaume Gautreau , Brice Targat , Roger Le Grand
Journal articles hal-02386051v1
Image document

Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry

Romain Marlin , Marie-Thérèse Nugeyre , Nicolas Tchitchek , Matteo Parenti , Hakim Hocini
Journal of Immunology, 2017, 199 (5), pp.1923 - 1932. ⟨10.4049/jimmunol.1700320⟩
Journal articles pasteur-01597708v1

In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry.

Jamila Elhmouzi-Younes , Jean-Louis Palgen , Nicolas Tchitchek , Simon Delandre , Inana Namet
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2017, 91 (10), pp.969--982. ⟨10.1002/cyto.a.23107⟩
Journal articles hal-03961018v1
Image document

Analysis methodology and development of a statistical tool for biodistribution data from internal contamination with actinides

Stephanie Lamart , Nina Griffiths , Nicolas Tchitchek , Jaime Angulo , Anne van der Meeren
Journal of Radiological Protection, 2017, 37 (1), pp.296-308. ⟨10.1088/1361-6498/37/1/296⟩
Journal articles hal-03856452v1

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta
Journal of Virology, 2016, 90, pp.2240 - 2253. ⟨10.1128/jvi.02974-15⟩
Journal articles hal-04493263v1

Identification of Vaccine-Altered Circulating B Cell Phenotypes Using Mass Cytometry and a Two-Step Clustering Analysis.

David Pejoski , Nicolas Tchitchek , André Rodriguez Pozo , Jamila Elhmouzi-Younes , Rahima Yousfi-Bogniaho
Journal of immunology (Baltimore, Md. : 1950), 2016, 196 (11), pp.4814--4831. ⟨10.4049/jimmunol.1502005⟩
Journal articles hal-03961021v1
Image document

The 1918 influenza virus PB2 protein enhances virulence through the disruption of inflammatory and Wnt-mediated signaling in mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta
Journal of Virology, 2016, 90 (5), pp.2240-2253. ⟨10.1128/JVI.02974-15⟩
Journal articles hal-03851553v1

Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study

Diane Bodez , Hakim Hocini , Nicolas Tchitchek , Pascaline Tisserand , Nicole Benhaiem
PLoS ONE, 2016, 11 (11), pp.e0167213. ⟨10.1371/journal.pone.0167213⟩
Journal articles hal-03987039v1

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta
Journal of Virology, 2016, 90, pp.2240 - 2253. ⟨10.1128/jvi.02974-15⟩
Journal articles hal-04493274v1
Image document

Delayed Inflammatory and Cell Death Responses Are Associated with Reduced Pathogenicity in Lujo Virus-Infected Cynomolgus Macaques

Angela L Rasmussen , Nicolas Tchitchek , David Safronetz , Victoria S Carter , Christopher M Williams
Journal of Virology, 2015, 89 (5), pp.2543 - 2552. ⟨10.1128/jvi.02246-14⟩
Journal articles hal-03851569v1
Image document

Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria.

Fabien Herbert , Nicolas Tchitchek , Devendra Bansal , Julien Jacques , Sulabha Pathak
Journal of Translational Medicine, 2015, 13, pp.369. ⟨10.1186/s12967-015-0731-6⟩
Journal articles hal-02051283v1

Sequencing, annotation and analysis of the Syrian hamster (Mesocricetus auratus) transcriptome.

Nicolas Tchitchek , David Safronetz , Angela L. Rasmussen , Craig Martens , Kimmo Virtaneva
PLoS ONE, 2014, 9 (11), pp.e112617. ⟨10.1371/journal.pone.0112617⟩
Journal articles hal-03961022v1

A comprehensive collection of systems biology data characterizing the host response to viral infection.

Brian D. Aevermann , Brett E. Pickett , Sanjeev Kumar , Edward B. Klem , Sudhakar Agnihothram
Scientific Data, 2014, 1, pp.140033. ⟨10.1038/sdata.2014.33⟩
Journal articles hal-03961036v1

H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice.

Juliet Morrison , Laurence Josset , Nicolas Tchitchek , Jean Chang , Jessica A. Belser
Journal of virology, 2014, 88 (18), pp.10556--10568. ⟨10.1128/JVI.00570-14⟩
Journal articles hal-03961023v1

Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts.

Laurence Josset , Nicolas Tchitchek , Lisa E. Gralinski , Martin T. Ferris , Amie J. Eisfeld
RNA biology, 2014, 11 (7), pp.875--890. ⟨10.4161/rna.29442⟩
Journal articles hal-03961024v1

Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.

Marcus J. Korth , Nicolas Tchitchek , Arndt G. Benecke , Michael G. Katze
Seminars in immunology, 2013, 25 (3), pp.228--239. ⟨10.1016/j.smim.2012.11.001⟩
Journal articles hal-03961025v1
Image document

1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice

Tokiko Watanabe , Jennifer Tisoncik-Go , Nicolas Tchitchek , Shinji Watanabe , Arndt G. Benecke
Journal of Virology, 2013, 87 (9), pp.5239-5254. ⟨10.1128/JVI.02753-12⟩
Journal articles hal-01543311v1
Image document

A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses

Hugh D. Mitchell , Amie J. Eisfeld , Amy C. Sims , Jason E. Mcdermott , Melissa M. Matzke
PLoS ONE, 2013, 8 (7), pp.e69374. ⟨10.1371/journal.pone.0069374⟩
Journal articles hal-01543316v1
Image document

Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice

Nicolas Tchitchek , Amie Eisfeld , Jennifer Tisoncik-Go , Laurence Josset , Lisa Gralinski
BMC Systems Biology, 2013, 7 (1), pp.69. ⟨10.1186/1752-0509-7-69⟩
Journal articles pasteur-00850969v1
Image document

Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus.

Nicolas Tchitchek , Béatrice Jacquelin , Patrick Wincker , Carole Dossat , Corinne Da Silva
BMC Genomics, 2012, 13 (1), pp.279. ⟨10.1186/1471-2164-13-279⟩
Journal articles inserm-00771549v1
Image document

2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

Jennifer Go , Sarah Belisle , Nicolas Tchitchek , Terrence Tumpey , Wenjun Ma
BMC Genomics, 2012, 13 (1), pp.627. ⟨10.1186/1471-2164-13-627⟩
Journal articles hal-03849383v1
Image document

CDS: A Fold-change Based Statistical Test for Concomitant Identification of Distinctness and Similarity in Gene Expression Analysis

Nicolas Tchitchek , José Felipe Golib Dzib , Brice Targat , Sebastian Noth , Arndt Benecke
Genomics, Proteomics and Bioinformatics, 2012, 10 (3), pp.127-135. ⟨10.1016/j.gpb.2012.06.002⟩
Journal articles hal-01544156v1

Improving the efficiency of multidimensional scaling in the analysis of high-dimensional data using singular value decomposition.

Christophe Bécavin , Nicolas Tchitchek , Colette Mintsa-Eya , Annick Lesne , Arndt Benecke
Bioinformatics (Oxford, England), 2011, 27 (10), pp.1413--1421. ⟨10.1093/bioinformatics/btr143⟩
Journal articles hal-03961026v1
Image document

A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections

Stewart Chang , Nicolas Tchitchek , Debashis Ghosh , Arndt Benecke , Michael Katze
BMC Systems Biology, 2011, 5 (1), pp.202. ⟨10.1186/1752-0509-5-202⟩
Journal articles hal-03849356v1

Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1.

Fábio L. Fernandes-Rosa , Edwige-Ludiwyne Hubert , Jérome Fagart , Nicolas Tchitchek , Debora Gomes
The Journal of clinical endocrinology and metabolism, 2011, 96 (3), pp.E519--527. ⟨10.1210/jc.2010-1486⟩
Journal articles hal-03961027v1
Image document

The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea.

Kathrin Endt , Bärbel Stecher , Samuel Chaffron , Emma Slack , Nicolas Tchitchek
PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩
Journal articles inserm-00520162v1