NT

Nicolas Tchitchek

91%
Libre accès
77
Documents
Affiliation actuelle
  • Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3)
Contact

Présentation

Ma recherche se concentre sur la caractérisation des dysrégulations moléculaires, cellulaires et microbiennes dans les troubles auto-immuns et auto-inflammatoires, à la fois en état stable et en réponse aux immunothérapies, en utilisant des approches d'immunologie systémique.

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Publications

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Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types

Nicolas Tchitchek , Marie Binvignat , Alexandra Roux , Fabien Pitoiset , Johanna Dubois et al.
Annals of the Rheumatic Diseases, 2024, ⟨10.1136/ard-2023-225179⟩
Article dans une revue hal-04490369 v1

A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing–remitting multiple sclerosis

C Louapre , M Rosenzwajg , M Golse , A Roux , F Pitoiset et al.
Journal of Neurology, 2023, 270, pp.4403 - 4414. ⟨10.1007/s00415-023-11690-6⟩
Article dans une revue hal-04490382 v1

Early systemic inflammation induces neurodevelopmental disorders: results from ARTEMIS, a French multicenter study of juvenile rheumatisms and systemic autoimmune and auto-inflammatory disorders and meta-analysis

Pierre Ellul , Isabelle Melki , Stephanie Antoun , Laura Lavialle , Eric Acquaviva et al.
Molecular Psychiatry, 2023, ⟨10.1038/s41380-023-01980-w⟩
Article dans une revue hal-03985785 v1
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Naive and memory CD4 + T cell subsets can contribute to the generation of human Tfh cells

Raphaël Jeger-Madiot , Romain Vaineau , Maud Heredia , Nicolas Tchitchek , Lisa Bertrand et al.
iScience, 2022, 25 (1), pp.103566. ⟨10.1016/j.isci.2021.103566⟩
Article dans une revue hal-03854774 v2
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The Tsallis generalized entropy enhances the interpretation of transcriptomics datasets

Nicolas Dérian , Hang-Phuong Pham , Djamel Nehar-Belaid , Nicolas Tchitchek , David Klatzmann et al.
PLoS ONE, 2022, 17 (4), pp.e0266618. ⟨10.1371/journal.pone.0266618⟩
Article dans une revue hal-03854768 v1
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Identification of Symptoms Phenotypes of Hand Osteoarthritis using Hierarchical Clustering: Results from the <scp>DIGICOD</scp> Cohort

Marie Binvignat , Gabriel Pires , Nicolas Tchitchek , Félicie Costantino , Alice Courties et al.
Arthritis Care & Research = Arthritis Care and Research, In press, ⟨10.1002/acr.25047⟩
Article dans une revue hal-03843031 v1

Long-term outcome of paediatric anti-N-methyl-D-aspartate receptor encephalitis.

Lorraine Flet-Berliac , Nicolas Tchitchek , Anne Lépine , Anca Florea , Hélène Maurey et al.
Developmental medicine and child neurology, 2022, ⟨10.1111/dmcn.15429⟩
Article dans une revue hal-03960996 v1
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The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

Yanis Feraoun , Jean-Louis Palgen , Candie Joly , Nicolas Tchitchek , Ernesto Marcos-Lopez et al.
Frontiers in Immunology, 2022, 12, pp.784813. ⟨10.3389/fimmu.2021.784813⟩
Article dans une revue hal-03787905 v1

Long‐term outcome of paediatric <scp>anti‐<i>N</i>‐methyl‐D</scp><scp>‐</scp>aspartate receptor encephalitis

Lorraine Flet‐berliac , Nicolas Tchitchek , Anne Lépine , Anca Florea , Hélène Maurey et al.
Developmental Medicine and Child Neurology, 2022, 65, pp.691 - 700. ⟨10.1111/dmcn.15429⟩
Article dans une revue hal-04490426 v1
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Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation

Nicolas Tchitchek , Otriv Nguekap Tchoumba , Gabriel Pires , Sarah Dandou , Julien Campagne et al.
JCI Insight, 2022, 7 (17), ⟨10.1172/jci.insight.159406⟩
Article dans une revue hal-03797609 v1
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Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial

Antoine Monsel , Caroline Hauw-Berlemont , Miryam Mebarki , Nicholas Heming , Julien Mayaux et al.
Critical Care, 2022, 26 (1), ⟨10.1186/s13054-022-03930-4⟩
Article dans une revue hal-03604084 v1
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Predictive Markers of Immunogenicity and Efficacy for Human Vaccines

Matthieu van Tilbeurgh , Katia Lemdani , Anne-Sophie Beignon , Catherine Chapon , Nicolas Tchitchek et al.
Vaccines, 2021, 9 (6), pp.579. ⟨10.3390/vaccines9060579⟩
Article dans une revue hal-03278510 v1
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Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , André Rodriguez Pozo , Lev Stimmer et al.
Frontiers in Immunology, 2021, 12, pp.645210. ⟨10.3389/fimmu.2021.645210⟩
Article dans une revue hal-03321921 v1
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Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections

Nicolas Huot , Philippe Rascle , Nicolas Tchitchek , Benedikt Wimmer , Caroline Passaes et al.
iScience, 2021, 24 (4), pp.102314. ⟨10.1016/j.isci.2021.102314⟩
Article dans une revue hal-03225293 v1
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Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Erminia Rubino , Melania Cruciani , Nicolas Tchitchek , Anna Le Tortorec , Antoine Rolland et al.
Frontiers in Genetics, 2021, 11, ⟨10.3389/fgene.2020.627007⟩
Article dans une revue hal-03154598 v1
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Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants

Mariangela Cavarelli , Stéphane Hua , Naima Hantour , Sabine Tricot , Nicolas Tchitchek et al.
Communications Biology, 2021, 4, pp.861. ⟨10.1038/s42003-021-02383-9⟩
Article dans une revue hal-03287057 v1

Bacnet: a user-friendly platform for building multi-omics websites.

Loane Danès , Nicolas Tchitchek , Christophe Bécavin
Bioinformatics (Oxford, England), 2021, 37 (9), pp.1335--1336. ⟨10.1093/bioinformatics/btaa828⟩
Article dans une revue hal-03961011 v1
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DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

Simon P. Jochems , Beatrice Jacquelin , Nicolas Tchitchek , Florence Busato , Fabien Pichon et al.
Clinical Epigenetics, 2020, 12 (1), pp.188. ⟨10.1186/s13148-020-00971-w⟩
Article dans une revue hal-03225306 v1

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination

Lucille Adam , Nicolas Tchitchek , Biliana Todorova , Pierre Rosenbaum , Candie Joly et al.
Journal of Immunology, 2020, 204 (12), pp.3375-3388. ⟨10.4049/jimmunol.1900517⟩
Article dans une revue hal-03984525 v1
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Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses After Electroporated DNA Vaccination

Lucille Adam , Nicolas Tchitchek , Biliana Todorova , Pierre Rosenbaum , Candie Joly et al.
Journal of Immunology, 2020, 204 (12), pp.3375-3388. ⟨10.4049/jimmunol.1900517⟩
Article dans une revue inserm-02869578 v1
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Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations

Jean-Louis Palgen , Nicolas Tchitchek , André Rodriguez-Pozo , Quentin Jouhault , Hadjer Abdelhouahab et al.
NPJ vaccines, 2020, 5, ⟨10.1038/s41541-020-0175-8⟩
Article dans une revue hal-03079492 v1
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Mechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine

Jessica Gonnet , Lauranne Poncelet , Celine Meriaux , Elena Gonçalves , Lina Weiss et al.
Journal of Proteomics, 2020, 216, pp.103670. ⟨10.1016/j.jprot.2020.103670⟩
Article dans une revue hal-03984601 v2
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Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals

Adrien Leite Pereira , Quentin Jouhault , Ernesto Marcos Lopez , Antonio Cosma , Olivier Lambotte et al.
Frontiers in Immunology, 2020, 11 (6), pp.579. ⟨10.3389/fimmu.2020.02096⟩
Article dans une revue hal-03960814 v1
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Salivary gland epithelial cells from patients with Sjögren's syndrome induce B-lymphocyte survival and activation

Elodie Riviere , Juliette Pascaud , Nicolas Tchitchek , Saida Boudaoud , Audrey Paoletti et al.
Annals of the Rheumatic Diseases, 2020, 79 (11), pp.1468-1477. ⟨10.1136/annrheumdis-2019-216588⟩
Article dans une revue inserm-03150054 v1
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Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study

Michelle Rosenzwajg , Randa Salet , Roberta Lorenzon , Nicolas Tchitchek , Alexandra Roux et al.
Diabetologia, 2020, 63 (9), pp.1808-1821. ⟨10.1007/s00125-020-05200-w⟩
Article dans une revue hal-03345047 v1
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Interleukin‐7/Interferon axis drives T‐cell and salivary gland epithelial cell interactions in Sjögren’s syndrome

Elodie Rivière , Juliette Pascaud , Alexandre Virone , Anastasia Dupré , Bineta Ly et al.
Arthritis & rheumatology, 2020, 73 (4), pp.631-640. ⟨10.1002/art.41558⟩
Article dans une revue pasteur-03036519 v1
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Early blood transcriptomic signature predicts patients’ outcome after out-of-hospital cardiac arrest

Renaud Tissier , Hakim Hocini , Nicolas Tchitchek , Nicolas Deye , Stéphane Legriel et al.
Resuscitation, 2019, 138, pp.222 - 232. ⟨10.1016/j.resuscitation.2019.03.006⟩
Article dans une revue hal-03485659 v1
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Characterization of Leukocytes From HIV-ART Patients Using Combined Cytometric Profiles of 72 Cell Markers.

Adrien Leite Pereira , Nicolas Tchitchek , Olivier Lambotte , Roger Le Grand , Antonio Cosma
Frontiers in Immunology, 2019, 10, pp.1777. ⟨10.3389/fimmu.2019.01777⟩
Article dans une revue hal-03961014 v1
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CytoBackBone: an algorithm for merging of phenotypic information from different cytometric profiles.

Adrien Leite Pereira , Olivier Lambotte , Roger Le Grand , Antonio Cosma , Nicolas Tchitchek
Bioinformatics, 2019, 35 (20), pp.4187-4189. ⟨10.1093/bioinformatics/btz212⟩
Article dans une revue hal-03961015 v1
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Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques

Marie-Thérèse Nugeyre , Nicolas Tchitchek , Cindy Adapen , Claude Cannou , Vanessa Contreras et al.
Frontiers in Cellular and Infection Microbiology, 2019, 9, pp.188. ⟨10.3389/fcimb.2019.00188⟩
Article dans une revue inserm-02433779 v1

Progenitors from the central nervous system drive neurogenesis in cancer

Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Alexis-Pierre Bemelmans , Virginie Firlej et al.
Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩
Article dans une revue hal-03987060 v1
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Characterization of Phenotypes and Functional Activities of Leukocytes From Rheumatoid Arthritis Patients by Mass Cytometry.

Adrien Leite Pereira , Samuel Bitoun , Audrey Paoletti , Gaetane Nocturne , Ernesto Marcos Lopez et al.
Frontiers in Immunology, 2019, 10, pp.2384. ⟨10.3389/fimmu.2019.02384⟩
Article dans une revue hal-03961013 v1
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Cynomolgus macaque IL37 polymorphism and control of SIV infection

Takashi Shiina , Shingo Suzuki , Nicolas Congy-Jolivet , Alice Aarnink , Henri-Jean Garchon et al.
Scientific Reports, 2019, 9 (1), pp.7981. ⟨10.1038/s41598-019-44235-x⟩
Article dans une revue hal-02149363 v1

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Elena Gonçalves , Olivia Bonduelle , Angèle Soria , Pierre Loulergue , Alexandra Rousseau et al.
The Journal of clinical investigation, 2019, 129 (5), pp.1960-1971. ⟨10.1172/jci125372⟩
Article dans une revue hal-03160706 v1
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Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques

Claire-Maëlle Fovet , Lev Stimmer , Vanessa Contreras , Philippe Horellou , Audrey Hubert et al.
EBioMedicine, 2019, 47, pp.492-505. ⟨10.1016/j.ebiom.2019.08.052⟩
Article dans une revue hal-02305565 v1
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Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae

Romain Marlin , Marie-Thérèse Nugeyre , Nicolas Tchitchek , Matteo Parenti , Cécile Lefebvre et al.
Frontiers in Immunology, 2019, 10, pp.430. ⟨10.3389/fimmu.2019.00430⟩
Article dans une revue inserm-02433796 v1
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NK cell immune responses differ after prime and boost vaccination

Jean‐louis Palgen , Nicolas Tchitchek , Nicolas Huot , Jamila Elhmouzi-Younes , Cécile Lefebvre et al.
Journal of Leukocyte Biology, 2019, 105 (5), pp.1055-1073. ⟨10.1002/JLB.4A1018-391RR⟩
Article dans une revue hal-02385954 v1
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Progenitors from the central nervous system drive neurogenesis in cancer

Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Alexis-Pierre Bemelmans , Virginie Firlej et al.
Nature, 2019, 569 (7758), pp.672-678. ⟨10.1038/s41586-019-1219-y⟩
Article dans une revue cea-02186559 v1
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Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection

Sixtine Coindre , Nicolas Tchitchek , Lamine Alaoui , Bruno Vaslin , Christine Bourgeois et al.
Frontiers in Immunology, 2019, ⟨10.3389/fimmu.2019.02677⟩
Article dans une revue hal-02386129 v1
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Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

Che Serguera , Lev Stimmer , Claire-Maëlle Fovet , Philippe Horellou , Vanessa Contreras et al.
Journal of Neuroinflammation, 2019, 16, pp.244. ⟨10.1186/s12974-019-1637-7⟩
Article dans une revue cea-02397764 v1

Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Jean-Louis Palgen , Nicolas Tchitchek , Jamila Elhmouzi-Younes , Simon Delandre , Inana Namet et al.
Scientific Reports, 2018, 8 (1), pp.3087. ⟨10.1038/s41598-018-21222-2⟩
Article dans une revue hal-03984523 v1
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A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans

Adrien Leite Pereira , Nicolas Tchitchek , Ernesto Marcos Lopez , Olivier Lambotte , Roger Le Grand et al.
Cytokine, 2018, 111, pp.97 - 105. ⟨10.1016/j.cyto.2018.08.018⟩
Article dans une revue hal-03854788 v1

Navigating in the vast and deep oceans of high-dimensional biological data.

Nicolas Tchitchek
Methods (San Diego, Calif.), 2018, 132, pp.1--2. ⟨10.1016/j.ymeth.2017.11.009⟩
Article dans une revue hal-03961017 v1

Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , Lev Stimmer , Hakim Hocini et al.
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.00870⟩
Article dans une revue hal-03984590 v1
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Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection

Nadia Echebli , Nicolas Tchitchek , Stéphanie Dupuy , Timothée Bruel , Caroline Passaes et al.
PLoS ONE, 2018, 13 (1), pp.e0190334. ⟨10.1371/journal.pone.0190334⟩
Article dans une revue pasteur-02861901 v1
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Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

Jean-Louis Palgen , Nicolas Tchitchek , Jamila Elhmouzi-Younes , Simon Delandre , Inana Namet et al.
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-21222-2⟩
Article dans une revue hal-02385941 v1
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Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART

Sixtine Coindre , Nicolas Tchitchek , Lamine Alaoui , Bruno Vaslin , Christine Bourgeois et al.
Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.01217⟩
Article dans une revue hal-02386113 v1
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Molecular and cellular Dynamics in the skin, the lymph nodes, and the Blood of the immune response to intradermal injection of Modified Vaccinia ankara Vaccine

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , Lev Stimmer , Hakim Hocini et al.
Frontiers in Immunology, 2018, 9, pp.870. ⟨10.3389/fimmu.2018.00870⟩
Article dans une revue hal-02386077 v1

In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry.

Jamila Elhmouzi-Younes , Jean-Louis Palgen , Nicolas Tchitchek , Simon Delandre , Inana Namet et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2017, 91 (10), pp.969--982. ⟨10.1002/cyto.a.23107⟩
Article dans une revue hal-03961018 v1
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Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry

Romain Marlin , Marie-Thérèse Nugeyre , Nicolas Tchitchek , Matteo Parenti , Hakim Hocini et al.
Journal of Immunology, 2017, 199 (5), pp.1923 - 1932. ⟨10.4049/jimmunol.1700320⟩
Article dans une revue pasteur-01597708 v1
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A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data

Ludovic Platon , David Pejoski , Guillaume Gautreau , Brice Targat , Roger Le Grand et al.
Article dans une revue hal-02386051 v1

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus.

Pierre Roques , Karl Ljungberg , Beate M. Kümmerer , Leslie Gosse , Nathalie Dereuddre-Bosquet et al.
JCI Insight, 2017, 2 (6), pp.e83527. ⟨10.1172/jci.insight.83527⟩
Article dans une revue hal-03961019 v1
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SPADEVizR: an R package for Visualization, Analysis and Integration of SPADE results

Guillaume Gautreau , David Pejoski , Roger Le Grand , Antonio Cosma , Anne-Sophie Beignon et al.
Bioinformatics, 2017, pp.btw708. ⟨10.1093/bioinformatics/btw708⟩
Article dans une revue hal-02385937 v1
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Listeriomics : an Interactive Web Platform for Systems Biology of Listeria

Christophe Bécavin , Mikael Koutero , Nicolas Tchitchek , Franck Cerutti , Pierre Lechat et al.
mSystems, 2017, 2 (2), pp.e00186-16. ⟨10.1128/mSystems.00186-16⟩
Article dans une revue pasteur-01574970 v1
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Analysis methodology and development of a statistical tool for biodistribution data from internal contamination with actinides

Stephanie Lamart , Nina Griffiths , Nicolas Tchitchek , Jaime Angulo , Anne van der Meeren
Journal of Radiological Protection, 2017, 37 (1), pp.296-308. ⟨10.1088/1361-6498/37/1/296⟩
Article dans une revue hal-03856452 v1
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The 1918 influenza virus PB2 protein enhances virulence through the disruption of inflammatory and Wnt-mediated signaling in mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta et al.
Journal of Virology, 2016, 90 (5), pp.2240-2253. ⟨10.1128/JVI.02974-15⟩
Article dans une revue hal-03851553 v1

Identification of Vaccine-Altered Circulating B Cell Phenotypes Using Mass Cytometry and a Two-Step Clustering Analysis.

David Pejoski , Nicolas Tchitchek , André Rodriguez Pozo , Jamila Elhmouzi-Younes , Rahima Yousfi-Bogniaho et al.
Journal of immunology (Baltimore, Md. : 1950), 2016, 196 (11), pp.4814--4831. ⟨10.4049/jimmunol.1502005⟩
Article dans une revue hal-03961021 v1

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta et al.
Journal of Virology, 2016, 90, pp.2240 - 2253. ⟨10.1128/jvi.02974-15⟩
Article dans une revue hal-04493263 v1

Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study

Diane Bodez , Hakim Hocini , Nicolas Tchitchek , Pascaline Tisserand , Nicole Benhaiem et al.
PLoS ONE, 2016, 11 (11), pp.e0167213. ⟨10.1371/journal.pone.0167213⟩
Article dans une revue hal-03987039 v1

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

Adriana Forero , Jennifer Tisoncik-Go , Tokiko Watanabe , Gongxun Zhong , Masato Hatta et al.
Journal of Virology, 2016, 90, pp.2240 - 2253. ⟨10.1128/jvi.02974-15⟩
Article dans une revue hal-04493274 v1
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Delayed Inflammatory and Cell Death Responses Are Associated with Reduced Pathogenicity in Lujo Virus-Infected Cynomolgus Macaques

Angela L Rasmussen , Nicolas Tchitchek , David Safronetz , Victoria S Carter , Christopher M Williams et al.
Journal of Virology, 2015, 89 (5), pp.2543 - 2552. ⟨10.1128/jvi.02246-14⟩
Article dans une revue hal-03851569 v1
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Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria.

Fabien Herbert , Nicolas Tchitchek , Devendra Bansal , Julien Jacques , Sulabha Pathak et al.
Journal of Translational Medicine, 2015, 13, pp.369. ⟨10.1186/s12967-015-0731-6⟩
Article dans une revue hal-02051283 v1

A comprehensive collection of systems biology data characterizing the host response to viral infection.

Brian D. Aevermann , Brett E. Pickett , Sanjeev Kumar , Edward B. Klem , Sudhakar Agnihothram et al.
Scientific Data, 2014, 1, pp.140033. ⟨10.1038/sdata.2014.33⟩
Article dans une revue hal-03961036 v1

Sequencing, annotation and analysis of the Syrian hamster (Mesocricetus auratus) transcriptome.

Nicolas Tchitchek , David Safronetz , Angela L. Rasmussen , Craig Martens , Kimmo Virtaneva et al.
PLoS ONE, 2014, 9 (11), pp.e112617. ⟨10.1371/journal.pone.0112617⟩
Article dans une revue hal-03961022 v1

H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice.

Juliet Morrison , Laurence Josset , Nicolas Tchitchek , Jean Chang , Jessica A. Belser et al.
Journal of virology, 2014, 88 (18), pp.10556--10568. ⟨10.1128/JVI.00570-14⟩
Article dans une revue hal-03961023 v1

Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts.

Laurence Josset , Nicolas Tchitchek , Lisa E. Gralinski , Martin T. Ferris , Amie J. Eisfeld et al.
RNA biology, 2014, 11 (7), pp.875--890. ⟨10.4161/rna.29442⟩
Article dans une revue hal-03961024 v1
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Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice

Nicolas Tchitchek , Amie Eisfeld , Jennifer Tisoncik-Go , Laurence Josset , Lisa Gralinski et al.
BMC Systems Biology, 2013, 7 (1), pp.69. ⟨10.1186/1752-0509-7-69⟩
Article dans une revue pasteur-00850969 v1

Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.

Marcus J. Korth , Nicolas Tchitchek , Arndt G. Benecke , Michael G. Katze
Seminars in immunology, 2013, 25 (3), pp.228--239. ⟨10.1016/j.smim.2012.11.001⟩
Article dans une revue hal-03961025 v1
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A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses

Hugh D. Mitchell , Amie J. Eisfeld , Amy C. Sims , Jason E. Mcdermott , Melissa M. Matzke et al.
PLoS ONE, 2013, 8 (7), pp.e69374. ⟨10.1371/journal.pone.0069374⟩
Article dans une revue hal-01543316 v1
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1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice

Tokiko Watanabe , Jennifer Tisoncik-Go , Nicolas Tchitchek , Shinji Watanabe , Arndt G. Benecke et al.
Journal of Virology, 2013, 87 (9), pp.5239-5254. ⟨10.1128/JVI.02753-12⟩
Article dans une revue hal-01543311 v1
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Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus.

Nicolas Tchitchek , Béatrice Jacquelin , Patrick Wincker , Carole Dossat , Corinne Da Silva et al.
BMC Genomics, 2012, 13 (1), pp.279. ⟨10.1186/1471-2164-13-279⟩
Article dans une revue inserm-00771549 v1
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2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

Jennifer Go , Sarah Belisle , Nicolas Tchitchek , Terrence Tumpey , Wenjun Ma et al.
BMC Genomics, 2012, 13 (1), pp.627. ⟨10.1186/1471-2164-13-627⟩
Article dans une revue hal-03849383 v1
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CDS: A Fold-change Based Statistical Test for Concomitant Identification of Distinctness and Similarity in Gene Expression Analysis

Nicolas Tchitchek , José Felipe Golib Dzib , Brice Targat , Sebastian Noth , Arndt Benecke et al.
Genomics, Proteomics and Bioinformatics, 2012, 10 (3), pp.127-135. ⟨10.1016/j.gpb.2012.06.002⟩
Article dans une revue hal-01544156 v1

Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1.

Fábio L. Fernandes-Rosa , Edwige-Ludiwyne Hubert , Jérome Fagart , Nicolas Tchitchek , Debora Gomes et al.
Journal of Clinical Endocrinology and Metabolism, 2011, 96 (3), pp.E519--527. ⟨10.1210/jc.2010-1486⟩
Article dans une revue hal-03961027 v1
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A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections

Stewart Chang , Nicolas Tchitchek , Debashis Ghosh , Arndt Benecke , Michael Katze
BMC Systems Biology, 2011, 5 (1), pp.202. ⟨10.1186/1752-0509-5-202⟩
Article dans une revue hal-03849356 v1

Improving the efficiency of multidimensional scaling in the analysis of high-dimensional data using singular value decomposition.

Christophe Bécavin , Nicolas Tchitchek , Colette Mintsa-Eya , Annick Lesne , Arndt Benecke
Bioinformatics (Oxford, England), 2011, 27 (10), pp.1413--1421. ⟨10.1093/bioinformatics/btr143⟩
Article dans une revue hal-03961026 v1
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The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea.

Kathrin Endt , Bärbel Stecher , Samuel Chaffron , Emma Slack , Nicolas Tchitchek et al.
PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩
Article dans une revue inserm-00520162 v1