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Pascal Bonnet

Professeur de Chimie ; Vice-Président de la Recherche de l'Université d'Orléans
48
Documents
Affiliations actuelles
  • 199928
  • 300297
Identifiants chercheurs

Publications

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The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells

Katherine Yaacoub , Rémy Pedeux , Pierre Lafite , Ulrich Jarry , Samia Aci-Sèche
Current Issues in Molecular Biology, 2024, 46 (1), pp.710 - 728. ⟨10.3390/cimb46010046⟩
Article dans une revue hal-04439697v1
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DESIGN, SYNTHESIS AND CHARACTERISATION OF A NOVEL TYPE II B-RAF PARADOX BREAKER INHIBITOR

Rohit Arora , Joannes T.M. Linders , Samia Aci-Sèche , Thomas Verheyen , Erika van Heerde
European Journal of Medicinal Chemistry, 2023, 250, pp.115231. ⟨10.1016/j.ejmech.2023.115231⟩
Article dans une revue hal-04037562v1
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A perspective on the sharing of docking data

Samia Aci-Sèche , Stéphane Bourg , Pascal Bonnet , Joseph Rebehmed , Alexandre de Brevern
Data in Brief, 2023, 49 (22), pp.109386. ⟨10.1016/j.dib.2023.109386⟩
Article dans une revue hal-04251910v1
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Estimation of Drug-Target Residence Time by Targeted Molecular Dynamics Simulations

Sonia Ziada , Julien Diharce , Eric Raimbaud , Samia Aci-Sèche , Pierre Ducrot
Journal of Chemical Information and Modeling, 2022, ⟨10.1021/acs.jcim.2c00852⟩
Article dans une revue hal-03855904v1
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Design and biological evaluation of substituted 5,7-dihydro-6 H -indolo[2,3- c ]quinolin-6-one as novel selective Haspin inhibitors

Sreenivas Avula , Xudan Peng , Xingfen Lang , Micky Tortorella , Béatrice Josselin
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37 (1), pp.1632-1650. ⟨10.1080/14756366.2022.2082419⟩
Article dans une revue hal-03818922v1
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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

Frédéric Buron , Nuno Rodrigues , Thibault Saurat , Marie-Aude Hiebel , Stéphane Bourg
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Article dans une revue hal-03348966v1
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Palladium‐Catalyzed Regioselective C−H Arylation of 4‐Azaindazole at C3, C5 and C7 Positions

Soukaina Faarasse , Saïd El Kazzouli , Otmane Bourzikat , Stéphane Bourg , Samia Aci-Seche
Advanced Synthesis and Catalysis, 2021, 363 (16), pp.3937-3945. ⟨10.1002/adsc.202001421⟩
Article dans une revue hal-03416452v1
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Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions

Nicolas Bosc , Christophe Muller , Laurent Hoffer , David Lagorce , Stéphane Bourg
ACS Chemical Biology, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
Article dans une revue hal-02569625v1
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Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency

Nada Ibrahim , Pascal Bonnet , Jean-Daniel Brion , Jean-François Peyrat , Jerome Bignon
European Journal of Medicinal Chemistry, 2020, 199 (31), pp.112355. ⟨10.1016/j.ejmech.2020.112355⟩
Article dans une revue hal-03036489v1

VSPrep: A KNIME workflow for the preparation of molecular databases for virtual screening

Jose-Manuel Gally , Stéphane Bourg , Jade Fogha , Quoc-Tuan Do , Samia Aci-Sèche
Current Medicinal Chemistry, 2020, 27 (38), pp.6480-6494. ⟨10.2174/0929867326666190614160451⟩
Article dans une revue hal-02387324v1
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Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

Jonathan Elie , Omid Feizbakhsh , Nathalie Desban , Béatrice Josselin , Blandine Baratte
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.1840-1853. ⟨10.1080/14756366.2020.1825408⟩
Article dans une revue hal-03004407v1
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Comparative Assessment of Protein Kinase Inhibitors in Public Databases and in PKIDB

Colin Bournez , Fabrice Carles , Gautier Peyrat , Samia Aci-Seche , Stéphane Bourg
Molecules, 2020, 25 (14), pp.3226. ⟨10.3390/molecules25143226⟩
Article dans une revue hal-02904776v1
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Computational Analysis of Crystallization Additives for the Identification of New Allosteric Sites

Jade Fogha , Julien Diharce , Alan Obled , Samia Aci-Seche , Pascal Bonnet
ACS Omega, 2020, 5 (5), pp.2114-2122. ⟨10.1021/acsomega.9b02697⟩
Article dans une revue hal-02904687v1
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Cinchona-based zwitterionic stationary phases: Exploring retention and enantioseparation mechanisms in supercritical fluid chromatography with a fragmentation approach

Adrien Raimbault , Cam Mai Anh Ma , Martina Ferri , Stefanie Bäurer , Pascal Bonnet
Journal of Chromatography A, 2020, 1612, pp.460689. ⟨10.1016/j.chroma.2019.460689⟩
Article dans une revue hal-02904771v1
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In silico peptide ligation: Iterative Residue Docking and Linking as a new approach to predict protein-peptide interactions

Julien Diharce , Mickaël Cueto , Massimiliano Beltramo , Vincent Aucagne , Pascal Bonnet
Molecules, 2019, 24 (7), pp.1-14. ⟨10.3390/molecules24071351⟩
Article dans une revue hal-03525312v1
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An original class of small sized molecules as versatile fluorescent probes for cellular imaging

Doina Sirbu , Julien Diharce , Ivana Martinić , Nicolas Chopin , Svetlana Eliseeva
Chemical Communications, 2019, 55 (54), pp.7776-7779. ⟨10.1039/C9CC03765A⟩
Article dans une revue hal-02373125v1
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Hyphenation of ultra-high performance supercritical fluid chromatography with atmospheric pressure chemical ionisation high resolution mass spectrometry: Part 2. Study of chromatographic and mass spectrometry parameters for the analysis of natural non-polar compounds

Johanna Duval , Cyril Colas , Pascal Bonnet , Eric Lesellier
Journal of Chromatography A, 2019, 1596, pp.199 - 208. ⟨10.1016/j.chroma.2019.03.018⟩
Article dans une revue hal-03484950v1
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Residence Time Prediction of Type 1 and 2 Kinase Inhibitors from Unbinding Simulations

Abdennour Braka , Norbert Garnier , Pascal Bonnet , Samia Aci-Seche
Journal of Chemical Information and Modeling, 2019, 60 (1), pp.342-348. ⟨10.1021/acs.jcim.9b00497⟩
Article dans une revue hal-02494409v1

Enhanced molecular dynamics methods applied to drug design projects

Sonia Ziada , Abdennour Braka , Julien Diharce , Samia Aci-Seche , Pascal Bonnet
Methods in Molecular Biology, 2018, 1762, pp.403-426. ⟨10.1007/978-1-4939-7756-7_20⟩
Article dans une revue hal-01966502v1

Synthesis of novel series of 7,7 '-(substituted methylene) bis-imidazo 1,2-b pyrazoles via an acid catalyzed one-pot three-component reaction

Mohsine Driowya , Hassan Allouchi , Jose Manuel Gally , Pascal Bonnet , Gérald Guillaumet
New Journal of Chemistry, 2018, 42 (8), pp.5728-5741. ⟨10.1039/c7nj05088g⟩
Article dans une revue hal-02620165v1
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Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors

Bruno Oyallon , Marie Brachet-Botineau , Cédric Logé , Pascal Bonnet , Mohamed Souab
European Journal of Medicinal Chemistry, 2018, 154, pp.101-109. ⟨10.1016/j.ejmech.2018.04.056⟩
Article dans une revue hal-03408667v1

PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials

Fabrice Carles , Stéphane Bourg , Christophe Meyer , Pascal Bonnet
Molecules, 2018, 23 (4), pp.908. ⟨10.3390/molecules23040908⟩
Article dans une revue hal-04272950v1
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Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

Florence Couly , Marine Harari , Carole Dubouilh-Benard , Laëtitia Bailly , Emilie Petit
Molecules, 2018, 23 (9), pp.2181. ⟨10.3390/molecules23092181⟩
Article dans une revue hal-02024491v1

PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials

Fabrice Carles , Stéphane Bourg , Christophe Meyer , Pascal Bonnet
Molecules, 2018, 23 (4), pp.908. ⟨10.3390/molecules23040908⟩
Article dans une revue hal-02904769v1

VSPrep: A General KNIME Workflow for the Preparation of Molecules for Virtual Screening

José-Manuel Gally , Stéphane Bourg , Quoc-Tuan Do , Samia Aci-Seche , Pascal Bonnet
Molecular Informatics, 2017, 36 (10), pp.1700023. ⟨10.1002/minf.201700023⟩
Article dans une revue hal-02904764v1

Comprehensive Network Map of ADME-Tox Databases

Baptiste Canault , Stéphane Bourg , Philippe Vayer , Pascal Bonnet
Molecular Informatics, 2017, 36 (10), pp.1700029. ⟨10.1002/minf.201700029⟩
Article dans une revue hal-02904766v1

Advanced molecular dynamics simulation methods for kinase drug discovery

Samia Aci-Seche , Sonia Ziada , Abdennour Braka , Rohit Arora , Pascal Bonnet
Future Medicinal Chemistry, 2016, 8 (5), pp.545-566. ⟨10.4155/fmc.16.9⟩
Article dans une revue hal-02494426v1

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors

Aziz Ouach , Rajâa Boulahjar , Christine Vala , Stéphane Bourg , Pascal Bonnet
European Journal of Medicinal Chemistry, 2016, 115, pp.311--325. ⟨10.1016/j.ejmech.2016.02.072⟩
Article dans une revue hal-01295635v1
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30th Franco-Belgian conference of pharmacochemistry

Charlotte Bouckaert , Eric Goffin , Sebastien Dilly , Julien Hanson , Lionel Pochet
Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩
Article dans une revue hal-02141338v1

Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase

Ozkan Sari , Vincent Roy , Mathieu Métifiot , Christophe Marchand , Yves Pommier
European Journal of Medicinal Chemistry, 2015, 104, pp.127-138. ⟨10.1016/j.ejmech.2015.09.015⟩
Article dans une revue hal-02904762v1

Iron-Catalyzed Trifluoromethylation of Enamide

Romain Rey-Rodriguez , Pascal Retailleau , Pascal Bonnet , Isabelle Gillaizeau
Chemistry - A European Journal, 2015, 21 (9), pp.3572-3575. ⟨10.1002/chem.201406333⟩
Article dans une revue hal-01163306v1
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Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.

Rajâa Boulahjar , Aziz Ouach , Stéphane Bourg , Pascal Bonnet , Olivier Lozach
European Journal of Medicinal Chemistry, 2015, 101, pp.274-287. ⟨10.1016/j.ejmech.2015.06.046⟩
Article dans une revue hal-01212495v1

Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness

Pierre-Francois Cartron , Mathilde Cheray , Arulraj Nadaradjane , Pascal Bonnet , Sylvain Routier
Epigenomics, 2014, 6 (3), pp.267-275. ⟨10.2217/epi.14.18⟩
Article dans une revue inserm-02478615v1

Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors

Thibault Saurat , Frédéric Buron , Nuno Rodrigues , Marie-Ludivine de Tauzia , Lionel Colliandre
Journal of Medicinal Chemistry, 2014, 57 (3), pp.613-631. ⟨10.1021/jm401138v⟩
Article dans une revue hal-01180887v1

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted Pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors

Oussama Dehbi , Abdellatif Tikad , Stéphane Bourg , Pascal Bonnet , Olivier Lozach
European Journal of Medicinal Chemistry, 2014, 80, pp.352-363. ⟨10.1016/j.ejmech.2014.04.055⟩
Article dans une revue hal-02904758v1
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Two-Step One-Pot Synthesis of Benzoannulated Spiroacetals by Suzuki–Miyaura Coupling/Acid-Catalyzed Spiroacetalization

Alexey N. Butkevich , Andrei Corbu , Lieven Meerpoel , Ian Stansfield , Patrick Angibaud
Organic Letters, 2012, 14, pp.4998 - 5001. ⟨10.1021/ol302088w⟩
Article dans une revue hal-03102296v1

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase

João Neres , Pascal Bonnet , Philip N Edwards , Pravin L Kotian , Alejandro Buschiazzo
Bioorganic and Medicinal Chemistry, 2007, 15 (5), pp.2106-2119. ⟨10.1016/j.bmc.2006.12.024⟩
Article dans une revue pasteur-02554109v1
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PrePeP – A Tool for the Identification and Characterization of Pan Assay Interference Compounds

Maksim Koptelov , Albrecht Zimmermann , Pascal Bonnet , Ronan Bureau , Bruno Crémilleux
24th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, Aug 2018, Londres, United Kingdom. pp.462-471, ⟨10.1145/3219819.3219849⟩
Communication dans un congrès hal-01939468v1

Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose

Béatrice Vallée , Karen Plé , A. Cosson , M. Doudeau , F. Godin
Journée Fédération CBM-ICOA, Jan 2018, Orléans, France
Communication dans un congrès hal-02928530v1

Conception of DYRK1A kinase inhibitors via metal-catalyzed C-H arylation, inspired by fragment-growing studies

Florence Couly , Julien Diharce , Pascal Bonnet , Meijer Laurent , Corinne Fruit
International Electronic Conference on Medicinal Chemistry (ECMC, 4, 2018), Jean-Jacques Vanden Eynde (coord.), Nov 2018, [online], Belgium. ⟨10.3390/ecmc-4-05580⟩
Communication dans un congrès hal-02383907v1

Fragment covalent docking (FCD) approach: An innovative in silico tools for the prediction of peptide-protein interaction

Julien Diharce , Mickaël Cueto , Vincent Aucagne , Massimiliano Beltramo , Pascal Bonnet
256th National Meeting and Exposition of the American-Chemical-Society Nanoscience, Nanotechnology and Beyond (ACS), American Chemical Society (ACS). USA., Aug 2018, Boston, United States. pp.2
Communication dans un congrès hal-02734800v1

Neurofibromatosis type I: from basic to applied research

Béatrice Vallée , A. Cosson , M. Doudeau , F Godin , A. Braka
4th LIA Workshop, Jun 2017, Cracovie, Poland
Communication dans un congrès hal-02928517v1