PC

Patrick Chames

85
Documents
Affiliations actuelles
  • Centre National de la Recherche Scientifique (CNRS)
  • Institut National de la Santé et de la Recherche Médicale (INSERM)
  • Centre de Recherche en Cancérologie de Marseille (CRCM)
  • Institut Paoli-Calmettes (IPC)
  • Aix Marseille Université (AMU)
Contact

Présentation

The main interest of our lab is to use antibody engineering solutions to generate innovative molecules able to efficiently modulate the anti-tumor immune response through the recruitment and activation of immune cells using multispecific cell engagers or multispecific immune checkpoint inhibitors, or through the vectorization of radionuclides and nanoparticles.

Our team has developed a solid expertise in the generation and use of nanobodies, corresponding to the variable domain of antibodies naturally devoid of light chain found in camelids, for cancer therapy and diagnostic using in vitro selection methods. We are exploring the possibilities offered by this technology for the development of innovative cancer imaging and therapy approaches.

Domaines de recherche

Cancer Immunothérapie

Publications

Publications

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A syndecan-based genetic approach to coat the surface of small extracellular vesicles with Nanobodies

Lukas Hyka , Sofie Meeussen , Rania Ghossoub , Michiel de Coster , Elke de Bruyne et al.

2026

Pré-publication, Document de travail hal-05526712v1
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Cell-Based Immunization Combined with Single-Round Cell Panning Enables Discovery of PSMA-Targeting Nanobodies from Phage Display Libraries

Tong Yang , Joke Veldhoven-Zweistra , Maarten Ligtenberg , Sigrun Erkens , Mirella Vredenbregt-van den Berg et al.

2025

Pré-publication, Document de travail hal-05370885v1

Identification and optimization of trans-species reactive TfR1-binding VHH as tools for drug delivery across the blood-brain barrier

Marion David , Romy Cohen , Diane Beuzelin , Géraldine Ferracci , Marina Cresci et al.

2025

Pré-publication, Document de travail hal-05088982v1
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Chronic potentiation of metabotropic glutamate receptor 2 with a nanobody accelerates amyloidogenesis in Alzheimer’s disease.

Pierre-André Lafon , Mireille Elodie Tsitokana , Ugo Alenda , Clémentine Eva Philibert , Mathieu Oosterlaken et al.

2024

Pré-publication, Document de travail hal-04762110v1
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Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds

Yong Jian Wang , Claire Valotteau , Adrien Aimard , Lorenzo Villanueva , Dorota Kostrz et al.

2022

Pré-publication, Document de travail hal-03861138v1
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Engineering of ultra-small diagnostic nanoprobes through oriented conjugation of single-domain antibodies and quantum dots

Igor Nabiev , Alyona Sukhanova , Klervi Even-Desrumeaux , Patrick Chames , Daniel Baty et al.

2021

Pré-publication, Document de travail hal-03182577v1
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Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody

Melanie Scherer , Nadia Djabeur , Oliver Siering , Jean-Marc Jeckelmann , Marianne Wyss et al.

Nature Communications, 2026, 17 (1), pp.103. ⟨10.1038/s41467-025-67600-z⟩

Article dans une revue hal-05515511v1
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Cell-Based Immunization Combined with Single-Round Cell Panning Enables Discovery of PSMA-Targeting Nanobodies from Phage Display Libraries

Tong Yang , Joke Veldhoven-Zweistra , Maarten Ligtenberg , Sigrun Erkens , Mirella Vredenbregt-van Den Berg et al.

Biomolecules, 2026, 16 (2), pp.307. ⟨10.3390/biom16020307⟩

Article dans une revue hal-05515507v1
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Mesothelin biology and the evolving landscape of targeted immunotherapy

Remy Boisgard , Patrick Chames , Brigitte Kerfelec

Molecular Therapy: Oncology, 2026, 34 (1), pp.201148. ⟨10.1016/j.omton.2026.201148⟩

Article dans une revue hal-05530530v1
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Selection and optimization strategy for Rap1-targeting single-domain antibodies as platelet activation markers

Marie-Christine Alessi , Maxime Moulard , Daniele Boulay-Moine , Cyril Pons , Marielle Margier et al.

Research and Practice in Thrombosis and Haemostasis, 2025, 10 (1), pp.103294. ⟨10.1016/j.rpth.2025.103294⟩

Article dans une revue hal-05515537v1
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Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction

Mathieu Oosterlaken , Angelina Rogliardo , Tatiana Lipina , Pierre-André Lafon , Mireille Elodie Tsitokana et al.

Nature, In press, 645 (8079), pp.262-270. ⟨10.1038/s41586-025-09265-8⟩

Article dans une revue hal-05213386v1
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Nanobody-enhanced T cell cancer immunotherapy: Advancing precision medicine

Remy Boisgard , Juliette Prothon , Celia Torrielli , Patrick Chames , Brigitte Kerfelec

Molecular Therapy, 2025, Online ahead of print. ⟨10.1016/j.ymthe.2025.10.043⟩

Article dans une revue hal-05363771v1
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Quantitative Microscopy for Cell–Surface and Cell–Cell Interactions in Immunology

Beatriz Díaz-Bello , Dalia El Arawi , Rémy Torro , Patrick Chames , Kheya Sengupta et al.

Bio-protocol , 2025, 15 (1379), pp.e5427. ⟨10.21769/bioprotoc.5427⟩

Article dans une revue hal-05363758v1
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Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions

Rémy Torro , Beatriz Díaz-Bello , Dalia El Arawi , Ksenija Dervanova , Lorna Ammer et al. Article dans une revue hal-05371772v1
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Novel single-domain antibodies targeting a unique transferrin receptor 1 epitope for cross-species delivery of drugs in the central nervous system

Marion David , Romy Cohen , Diane Beuzelin , Géraldine Ferracci , Marina Cresci et al.

Journal of Controlled Release, 2025, 388, pp.114344. ⟨10.1016/j.jconrel.2025.114344⟩

Article dans une revue hal-05340484v1
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Nanobody-based canine PD-L1-targeting immune checkpoint inhibitors for cancer therapy in dogs

Morgane Di Palma Subran , Marianne Wyss , Betül Taskoparan , Mathischan Maheswaran , Johannes Vom Berg et al.

Molecular Therapy: Oncology, 2025, 33 (3), pp.201036. ⟨10.1016/j.omton.2025.201036⟩

Article dans une revue hal-05363743v1
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Decoupling individual host response and immune cell engager cytotoxic potency

Cristina Gonzalez Gutierrez , Adrien Aimard , Martine Biarnes-Pélicot , Brigitte Kerfelec , Pierre-Henri Puech et al.

ACS Nano, 2025, 19 (2), pp.2089-2098. ⟨10.1021/acsnano.4c08541⟩

Article dans une revue hal-04778416v1
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Functional targeting of Glypican-4 by a conformation-specific single-domain antibody

Remi Bonjean , Rossana Cuciniello , Brigitte Kerfelec , Patrick Chames , Rosanna Dono

Biomaterials, 2025, 328, pp.123864. ⟨10.1016/j.biomaterials.2025.123864⟩

Article dans une revue hal-05409215v1
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Antigen density and applied force control enrichment of nanobody-expressing yeast cells in microfluidics

Merlin Sanicas , Remy Torro , Laurent Limozin , Patrick Chames

Lab on a Chip, 2024, Online ahead of print. ⟨10.1039/D4LC00011K⟩

Article dans une revue hal-04562911v2
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Specific Targeting of Mesothelin-Expressing Malignant Cells Using Nanobody-Functionalized Magneto-Fluorescent Nanoassemblies

Tina Briolay , Judith Fresquet , Damien Meyer , Brigitte Kerfelec , Patrick Chames et al.

International Journal of Nanomedicine, 2024, 19, pp.633 - 650. ⟨10.2147/ijn.s435787⟩

Article dans une revue inserm-04465814v1
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Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses

Antonio Tapia-Galisteo , Iñigo Sánchez-Rodríguez , Javier Narbona , Patricia Iglesias-Hernández , Saray Aragón-García et al.

OncoImmunology, 2024, 13 (1), pp.2338558. ⟨10.1080/2162402X.2024.2338558⟩

Article dans une revue hal-04583762v1
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Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques

Floriane Eshak , Léo Pion , Pauline Scholler , Damien Nevoltris , Patrick Chames et al.

Journal of Chemical Information and Modeling, 2024, 64 (11), pp.4436-4461. ⟨10.1021/acs.jcim.3c01620⟩

Article dans une revue hal-04723363v1
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A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization

Nicolas de Leiris , Pascale Perret , Charlotte Lombardi , Bülent Gözel , Sabine Chierici et al.

Journal of Translational Medicine, 2024, 22 (1), pp.163. ⟨10.1186/s12967-024-04987-1⟩

Article dans une revue hal-04583802v1
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Tissue clearing and 3D reconstruction of digitized, serially sectioned slides provide novel insights into pancreatic cancer

Ashley Kiemen , Alexander Ioannis Damanakis , Alicia M Braxton , Jin He , Daniel Laheru et al.

Med, 2023, 4 (2), pp.75-91. ⟨10.1016/j.medj.2022.11.009⟩

Article dans une revue hal-04054727v1
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Rapid nanobody-based imaging of mesothelin expressing malignancies compatible with blocking therapeutic antibodies

Abdennour Benloucif , Damien Meyer , Laure Balasse , Armelle Goubard , Lucile Danner et al.

Frontiers in Immunology, 2023, 14, pp.1200652. ⟨10.3389/fimmu.2023.1200652⟩

Article dans une revue hal-04259727v1
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Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds

Yong Jian Wang , Claire Valotteau , Adrien Aimard , Lorenzo Villanueva , Dorota Kostrz et al.

Biophysical Journal, 2023, 122 (12), pp.2518-2530. ⟨10.1016/j.bpj.2023.05.004⟩

Article dans une revue hal-04165173v1
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Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

Antonio Tapia-Galisteo , Íñigo Sánchez Rodríguez , Oscar Aguilar-Sopeña , Seandean Lykke Harwood , Javier Narbona et al.

OncoImmunology, 2022, 11, ⟨10.1080/2162402x.2022.2034355⟩

Article dans une revue hal-03745498v1
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Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain

Jiyong Meng , Chanjuan Xu , Pierre-André Lafon , Salomé Roux , Michaël Mathieu et al.

Nature Chemical Biology, 2022, 18, pp.894-903. ⟨10.1038/s41589-022-01050-2⟩

Article dans une revue hal-03699580v1
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A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers

Jordi Haubrich , Joan Font , Robert Quast , Anne Goupil-Lamy , Pauline Scholler et al.

Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (33), pp.e2105848118. ⟨10.1073/pnas.2105848118⟩

Article dans une revue hal-03322348v1
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Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response

Adeline Raynaud , Klervi Desrumeaux , Laurent Vidard , Elise Termine , Daniel Baty et al.

OncoImmunology, 2020, 10, ⟨10.1080/2162402x.2020.1854529⟩

Article dans une revue hal-03371613v1
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Special Issue: Nanobody

Patrick Chames , Ulrich Rothbauer

Antibodies, 2020, 9 (1), pp.6. ⟨10.3390/antib9010006⟩

Article dans une revue hal-03017191v1
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A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

Franziska Hartung , Thomas Krüwel , Xiaoyi Shi , Klaus Pfizenmaier , Roland Kontermann et al.

Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00686⟩

Article dans une revue hal-03017218v1
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Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer

Timothée Chanier , Patrick Chames

Antibodies, 2019, 8 (1), pp.13. ⟨10.3390/antib8010013⟩

Article dans une revue hal-02002577v1
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A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

Joanie del Bano , Rémy Florès-Florès , Emmanuelle Josselin , Armelle Goubard , Laëtitia Ganier et al.

Frontiers in Immunology, 2019, 10, pp.1593. ⟨10.3389/fimmu.2019.01593⟩

Article dans une revue hal-02520930v1
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Nanobody-CD16 Catch Bond Reveals NK Cell Mechanosensitivity

Cristina González , Patrick Chames , Brigitte Kerfelec , Daniel Baty , Philippe Robert et al.

Biophysical Journal, 2019, 116 (8), pp.1516-1526. ⟨10.1016/j.bpj.2019.03.012⟩

Article dans une revue hal-02323625v1
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Les anticorps et scaffold bispécifiques, des médicaments innovants en oncologie impliquant le ciblage des cellules immunitaires

Patrick Chames , Thierry Wurch

Médecine/Sciences, 2019, 35 (12), pp.1072-1082. ⟨10.1051/medsci/2019242⟩

Article dans une revue hal-03017227v1

Nanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays

Alyona Sukhanova , Fernanda Ramos-Gomes , Patrick Chames , Daniel Baty , Frauke Alves et al.

Proceedings of SPIE, the International Society for Optical Engineering, 2019, pp.112072A. ⟨10.1117/12.2530233⟩

Article dans une revue hal-03007502v1

Advanced Nanotools for Imaging of Solid Tumors and Circulating and Disseminated Cancer Cells

D. Baty , I. Nabiev , A. Sukhanova , F. Ramos-Gomes , F. Alves et al.

Optics and Spectroscopy, 2018, 125 (5), pp.703-707. ⟨10.1134/S0030400X18110309⟩

Article dans une revue hal-02143643v1
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Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots

Fernanda Ramos-Gomes , Julia Bode , Alyona Sukhanova , Svetlana V Bozrova , Mara Saccomano et al.

Scientific Reports, 2018, 8 (1), pp.4595. ⟨10.1038/s41598-018-22973-8⟩

Article dans une revue hal-01765351v1
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Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

Pauline Scholler , Damien Nevoltris , Dimitri de Bundel , Simon Bossi , David Moreno-Delgado et al.

Nature Communications, 2017, 8 (1), pp.1967. ⟨10.1038/s41467-017-01489-1⟩

Article dans une revue hal-01672805v2

Nanosized Fluorescent Diagnostic Probes Consisting of Single-domain Antibodies Conjugated with Quantum Dots

Alyona Sukhanova , Klervi Even-Desrumeaux , Jean-Marc Millot , Patrick Chames , Daniel Baty et al.

Materials Today: Proceedings, 2016, 3 (2), pp.518-522. ⟨10.1016/j.matpr.2016.01.083⟩

Article dans une revue hal-03112307v1

Multiphoton Imaging of Tumor Biomarkers in situ Using Single-domain Antibodies Conjugated with Quantum Dots in a Set Orientation

Alyona Sukhanova , Hilal Hafian , Marc Turini , Patrick Chames , Daniel Baty et al.

Materials Today: Proceedings, 2016, 3 (2), pp.523-526. ⟨10.1016/j.matpr.2016.01.084⟩

Article dans une revue hal-03112311v1
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V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1

Marion Morgand , Mélanie Bouvin-Pley , Jean-Christophe Plantier , Moreau Alain , Elodie Alessandri et al.

Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2016, 71 (3), pp.237-245. ⟨10.1097/QAI.0000000000000854⟩

Article dans une revue hal-01314296v1

In vivo detection of small tumour lesions by multi-pinhole SPECT applying a (99m)Tc-labelled nanobody targeting the Epidermal Growth Factor Receptor.

Thomas Krüwel , Damien Nevoltris , Julia Bode , Christian Dullin , Daniel Baty et al.

Scientific Reports, 2016, 6, pp.21834

Article dans une revue hal-01450793v1
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Taking up Cancer Immunotherapy Challenges: Bispecific Antibodies, the Path Forward?

Joanie del Bano , Patrick Chames , Daniel Baty , Brigitte Kerfelec

Antibodies, 2016, 5 (1), ⟨10.3390/antib5010001⟩

Article dans une revue hal-01450799v1

Conformational nanobodies reveal tethered epidermal growth factor receptor involved in EGFR/ErbB2 predimers.

Damien Nevoltris , Benjamin Lombard , Elodie Dupuis , Gérard Mathis , Patrick Chames et al.

ACS Nano, 2015, 9 (2), pp.1388-99. ⟨10.1021/nn505752u⟩

Article dans une revue hal-01450765v1
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Oriented Conjugates of Single-domain Antibodies and Fluorescent Quantum Dots for Highly Sensitive Detection of Tumor-associated Biomarkers in Cells and Tissues

Regina Bilan , Kristina Brazhnik , Patrick Chames , Daniel Baty , Igor Nabiev et al.

Physics Procedia, 2015, 73, pp.228-234. ⟨10.1016/j.phpro.2015.09.162⟩

Article dans une revue hal-03112376v1

Detection of carcinoembryonic antigen using single-domain or full-size antibodies stained with quantum dot conjugates.

Gilles Rousserie , Regina Grinevich , Kristina Brazhnik , Klervi Even-Desrumeaux , Brigitte Reveil et al.

Analytical Biochemistry, 2015, 478, pp.26-32. ⟨10.1016/j.ab.2015.02.029⟩

Article dans une revue hal-01450782v1

Anti-Mesothelin Nanobodies for Both Conventional and Nanoparticle-Based Biomedical Applications.

Andrew M Prantner , Marc Turini , Brigitte Kerfelec , Shree Joshi , Daniel Baty et al.

Journal of Biomedical Nanotechnology, 2015, pp.1201-12

Article dans une revue hal-01450786v1
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A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

Marc Turini , Patrick Chames , Pierre Bruhns , Daniel Baty , Brigitte Kerfelec

Oncotarget, 2014, 5 (14), ⟨10.18632/oncotarget.2093⟩

Article dans une revue hal-02115462v1
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Selection of Intracellular Single-Domain Antibodies Targeting the HIV-1 Vpr Protein by Cytoplasmic Yeast Two-Hybrid System

Julie Matz , Cécile Hérate , Jérôme Bouchet , Nelson Dusetti , Odile Gayet et al.

PLoS ONE, 2014, 9 (12), pp.e113729. ⟨10.1371/journal.pone.0113729⟩

Article dans une revue inserm-01093997v1
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Masked Selection: A Straightforward and Flexible Approach for the Selection of Binders Against Specific Epitopes and Differentially Expressed Proteins by Phage Display

Klervi Even-Desrumeaux , Damien Nevoltris , Marie Noelle Lavaut , Karima Alim , Jean-Paul Borg et al.

Molecular and Cellular Proteomics, 2014, 13 (2), pp.653-665. ⟨10.1074/mcp.O112.025486⟩

Article dans une revue hal-02115444v1

Multiphoton imaging of tumor biomarkers with conjugates of single-domain antibodies and quantum dots

Hilal Hafian , Alyona Sukhanova , Marc Turini , Patrick Chames , Daniel Baty et al.

Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10 (8), pp.1701-1709. ⟨10.1016/j.nano.2014.05.014⟩

Article dans une revue hal-03136281v1

Highly Sensitive Single Domain Antibody–Quantum Dot Conjugates for Detection of HER2 Biomarker in Lung and Breast Cancer Cells

Tatsiana Rakovich , Omar Mahfoud , Bashir Mohamed , Adriele Prina-Mello , Kieran Crosbie-Staunton et al.

ACS Nano, 2014, 8 (6), pp.5682-5695. ⟨10.1021/nn500212h⟩

Article dans une revue hal-03136167v1

Detection of carcinoembryonic antigen on colon cancer cells using single-domain antibodies and quantum dots

R. Grinevich , G. Rousserie , K. Brazhnik , R. Even-Desrumeaux , B. Reveil et al.

Acta Naturae, 2014, Abstr. Conf. Science of the Future, St. Petersburg, 17-20 Sep 2014, Special issue, pp.76

Article dans une revue hal-03136098v1

Single-Domain Antibody-Based and Linker-Free Bispecific Antibodies Targeting Fc RIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells

C. Rozan , A. Cornillon , C. Petiard , M. Chartier , G. Behar et al.

Molecular Cancer Therapeutics, 2013, 12 (8), pp.1481-1491. ⟨10.1158/1535-7163.MCT-12-1012⟩

Article dans une revue hal-02115468v1

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

P. Acharya , T. Luongo , I. Georgiev , J. Matz , S. Schmidt et al.

Journal of Virology, 2013, 87 (18), pp.10173-10181. ⟨10.1128/JVI.01332-13⟩

Article dans une revue hal-02530765v1
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Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells.

Caroline Rozan , Amélie Cornillon , Corinne Petiard , M. Chartier , G. Behar et al.

Molecular Cancer Therapeutics, 2013, 12 (8), pp.1481-1491. ⟨10.1158/1535-7163.MCT-12-1012⟩

Article dans une revue hal-02454959v1
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Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120

Julie Matz , Pacal Kessler , Jérome Bouchet , Olivier Combes , Daniel Baty et al.

Retrovirology, 2012, 9 (Suppl 2), pp.P214

Article dans une revue inserm-00731772v1

Oriented conjugates of monoclonal and single-domain antibodies with quantum dots for flow cytometry and immunohistochemistry diagnostic applications

Alyona Sukhanova , Klervi Even-Desrumeaux , Jean-Marc Millot , Patrick Chames , Daniel Baty et al.

Proceedings of SPIE, the International Society for Optical Engineering, 2012, Colloidal Nanocrystals for Biomedical Applications VII, 8232, pp.82320T. ⟨10.1117/12.905896⟩

Article dans une revue hal-03184792v1
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Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization

Priyamvada Acharya , Timothy S. Luongo , Julie Matz , Stephen D. Schmidt , Gwo-Yu Chuang et al.

Retrovirology, 2012, 9 (Suppl 2), pp.P346

Article dans une revue inserm-00731776v1

Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes

Alyona Sukhanova , Klervi Even-Desrumeaux , Aymric Kisserli , Thierry Tabary , Brigitte Reveil et al.

Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8 (4), pp.516-525. ⟨10.1016/j.nano.2011.07.007⟩

Article dans une revue istex hal-03184846v1
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Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches.

Klervi Even-Desrumeaux , Patrick Fourquet , Véronique Secq , Daniel Baty , Patrick Chames

Molecular BioSystems, 2012, 8 (9), pp.2385-2394. ⟨10.1039/c2mb25063b⟩

Article dans une revue inserm-00722930v1

Bi-photon imaging and diagnostics using ultra-small diagnostic probes engineered from semiconductor nanocrystals and single-domain antibodies

Hilal Hafian , Alyona Sukhanova , Patrick Chames , Daniel Baty , Michel Pluot et al.

Proceedings of SPIE, the International Society for Optical Engineering, 2012, Nanosystems in Engineering and Medicine, 8548, pp.85480R. ⟨10.1117/12.960493⟩

Article dans une revue hal-03177842v1

Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120

J. Matz , P. Kessler , J. Bouchet , O. Combes , O. Ramos et al.

Journal of Virology, 2012, 87 (2), pp.1137-1149. ⟨10.1128/JVI.00461-12⟩

Article dans une revue cea-02530610v1

Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions

Jérôme Bouchet , Cécile Hérate , Carolin Guenzel , Christel Vérollet , Annika Järviluoma et al.

Journal of Virology, 2012, 86 (9), pp.4856-4867. ⟨10.1128/JVI.06329-11⟩

Article dans une revue hal-04958842v1
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Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation.

Klervi Even-Desrumeaux , Daniel Baty , Patrick Chames

Molecular BioSystems, 2010, 6 (11), pp.2241-8. ⟨10.1039/c005279e⟩

Article dans une revue inserm-00521371v1
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Therapeutic antibodies for the treatment of pancreatic cancer.

Patrick Chames , Brigitte Kerfelec , Daniel Baty

TheScientificWorldJournal, 2010, 10, pp.1107-20. ⟨10.1100/tsw.2010.103⟩

Article dans une revue inserm-00497886v1
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Therapeutic Antibodies for the Treatment of Pancreatic Cancer

Patrick Chames , Brigitte Kerfelec , Daniel Baty

The Scientific World Journal, 2010, 10, pp.1107-1120. ⟨10.1100/tsw.2010.103⟩

Article dans une revue hal-02115485v1

Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays.

G. Rousserie , A. Sukhanova , K. Even-Desrumeaux , F. Fleury , P. Chames et al.

Critical Reviews in Oncology/Hematology, 2009, 00 (00), pp.00

Article dans une revue hal-00415311v1
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Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

Patrick Chames , Daniel Baty

mAbs, 2009, 1 (6), pp.539-47

Article dans une revue inserm-00448211v1

Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen.

Ghislaine Behar , Patrick Chames , Isabelle Teulon , Amélie Cornillon , Faisal Alshoukr et al.

FEBS Journal, 2009, 276 (14), pp.3881-93. ⟨10.1111/j.1742-4658.2009.07101.x⟩

Article dans une revue hal-00420547v1
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[The future of antibody fragments, made of a single immunoglobulin domain.]

Patrick Chames , Daniel Baty

Médecine/Sciences, 2009, 25 (12), pp.1159-62

Article dans une revue inserm-00443810v1

Isolation and characterization of anti-Fc{gamma}RIII (CD16) llama single-domain antibodies that activate natural killer cells.

Ghislaine Behar , Sophie Sibéril , Agnès Groulet , Patrick Chames , Martine Pugnière et al.

Protein Engineering, Design and Selection, 2008, 21 (1), pp.1-10. ⟨10.1093/protein/gzm064⟩

Article dans une revue hal-00258940v1
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Isolation and characterization of anti-FcgRIII (CD16) llama single-domain antibodies that activate natural killer cells

Ghislaine Béhar , Sophie Sibéril , Agnès Groulet , Patrick Chames , Martine Pugnière et al.

Protein Engineering, Design and Selection, 2007, 21 (1), pp.1-10. ⟨10.1093/protein/gzm064⟩

Article dans une revue hal-02454965v1

Intracellular Immunization of Prokaryotic Cells against a Bacteriotoxin

Patrick Chames , Jacques Fieschi , Daniel Baty , Denis Duché

Journal of Bacteriology, 1998, 180 (3), pp.514-518. ⟨10.1128/JB.180.3.514-518.1998⟩

Article dans une revue hal-03269515v1

Nanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays

Alyona Sukhanova , Fernanda Ramos-Gomes , Patrick Chames , Daniel Baty , Frauke Alves et al.

IV International Conference on Applications of Optics and Photonics, May 2019, Lisbon, France. pp.186, ⟨10.1117/12.2530233⟩

Communication dans un congrès hal-03017208v1

Multiphoton imaging of tumor biomarkers in situ using highly oriented conjugates of single-domain antibodies and quantum dots

Alyona Sukhanova , Hilal Hafian , Michel Pluot , Jacques Cohen , Jean-Marc Millot et al.

2015 International Conference on Biomedical Engineering and Computational Technologies (SIBIRCON), Oct 2015, Novosibirsk, France. pp.119-121, ⟨10.1109/SIBIRCON.2015.7361864⟩

Communication dans un congrès hal-03112342v1

Single-photon and two-photon tumor imaging and diagnosis using oriented conjugates of single-domain antibodies and quantum dots.

A. Sukhanova , I. Nabiev , H. Hafian , M. Pluot , J.H.M. Cohen et al.

Physics, Chemistry And Applications Of Nanostructures - Proceedings Of The International Conference Nanomeeting - 2015, 2015, Minsk, Belarus. pp.O-31, 495-498

Communication dans un congrès hal-03134832v1