
Patrick MEFFRE
- Nîmes Université (UNIMES)
- Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université (CHROME)
Présentation
Patrick Meffre est né à Marseille, en France, en 1964. Après des études d'ingénieur à l'École nationale supérieure de chimie de Paris (ENSCP, Chimie ParisTech-PSL, membre de l'Université Paris-Sciences et Lettres, PSL, France), il a obtenu son doctorat à l'Université Pierre et Marie Curie (Paris) en 1991 sous la direction du professeur F. Le Goffic. Après un stage postdoctoral auprès du professeur S. Hanessian (Université de Montréal, Québec, Canada), il a été nommé maître de conférences à l'École nationale supérieure de chimie de Paris en 1993. Depuis 2004, il est professeur titulaire à l'Université de Nîmes (France).
Ses centres d'intérêt actuels concernent :
-L'extraction et l'identification de composés naturels d'origine végétale, notamment les composés organiques volatils (COV), et leur activité biologique.
-La synthèse de composés biologiquement actifs, chiraux ou non, (agents antibactériens, adjuvants), d'acides aminés inhabituels, de synthons chiraux dérivés d'acides aminés naturels et l'étude de leur activité biologique.
-L'utilisation de plantes épiphytes (genre Tillandsia) comme source naturelle de composés biologiquement actifs ou comme biomoniteurs de la pollution atmosphérique.
Patrick Meffre est rédacteur en chef adjoint de la revue Amino Acids (Springer) https://www.springer.com/journal/726
Domaines de recherche
Publications
Publications
Analysis of the Volatile Organic Compounds of Tillandsia flowers by HS-SPME/GC-MSAnalytics 2022, Sep 2022, Nantes, France
Communication dans un congrès
hal-03806502
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E2f1 contrôle la fonction et l’identité de la cellule beta pancréatique par un mécanisme dépendant des enzymes HDACCongrès de la Société Francophone du Diabète 2021, SFD, Mar 2021, Strasbourg (100% virtuel), France
Communication dans un congrès
hal-04461303
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Rational design, synthesis and antimicrobial properties of thiophene derivatives that inhibit bacterial histidine kinases2nd international conference Antimicrobial and antibacterial Istanbul Turkey, Nov 2019, Istanbul, Turkey
Communication dans un congrès
hal-02400581
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Rational design, synthesis and antimicrobial properties of thiophene derivatives that inhibit bacterial histidine kinases24th ISCB international conference-Frontier research in chemistry&biology interface, Jan 2018, JAIPUR, India
Communication dans un congrès
hal-01998540
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Addendum to Abstracts presented at the 14th International Congress on Amino Acids, Peptides and Proteins14th International Congress on Amino Acids, Peptides and Proteins, Aug 2015, Vienna, Austria. pp.615-636
Communication dans un congrès
hal-02002708
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Synthesis of 5-trifluoromethylproline from L-glutamic acid14th International Congress on Amino Acids, Peptides and Proteins, Aug 2015, Wien, Austria. pp.615-636, ⟨10.1007/s00726-015-2160-5⟩
Communication dans un congrès
hal-02010135
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Synthesis of acetylenic analogue of phenylalanine.13th International Congress on Amino acids, peptides and proteins, Oct 2013, Galvestion (Texas), United States. pp.611, ⟨10.1007/s00726-013-1540-y⟩
Communication dans un congrès
hal-00993416
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New developments in the synthesis of acetylenic analogues of glutamate12 th International Congress on Amino Acids, Peptides and Proteins, Aug 2011, Beijing, China. pp.S79, ⟨10.1007/s00726-011-0955-6⟩
Communication dans un congrès
istex
hal-00621161
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Synthesis of acetylenic analogues of glutamate10th International Congress on amino acids and proteins, Aug 2007, Kallithea, Greece
Communication dans un congrès
hal-01998510
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Synthesis of acetylenic analogues of glutamate10th International Congress on Amino Acids and Proteins (ICAAP), Aug 2007, Kalithea, Chalkidiki, Greece. pp.I-LXX, ⟨10.1007/s00726-007-0578-0⟩
Communication dans un congrès
hal-02010124
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New developments in the synthesis of fluorinated analogues of glutamic acid and glutamine8th International Congress on Aminoacids, Sep 2003, Roma, Italy. pp.111-204, ⟨10.1007/s00726-003-0037-5⟩
Communication dans un congrès
istex
hal-02010117
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Synthesis and biological evaluation of optically active fluorinated analogues of glutamine7th International Congress on Amino Acids and Proteins, Aug 2001, Wien, Austria. pp.1-90, ⟨10.1007/s007260170030⟩
Communication dans un congrès
hal-02010112
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Synthesis of optically active fluorinated analogues of glutamic acid and glutamine with potential biological activity6th International Congress on Amino Acids, Aug 1999, Bonn, Germany. pp.1-129, ⟨10.1007/BF01362415⟩
Communication dans un congrès
istex
hal-02010105
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Synthesis and uses of aspartaldehyde derivatives5th International Congress on Aminoacids, Aug 1997, Kalithea, Chalkidiki, Greece. pp.25-89, ⟨10.1007/BF01373046⟩
Communication dans un congrès
istex
hal-02010098
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New developments in the synthesis of optically active ethynylglycine derivatives4th International Congress on Aminoacids, Aug 1995, Wien, Austria. ⟨10.1007/BF00811751⟩
Communication dans un congrès
istex
hal-02010089
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Different aspects of synthetic approaches including enzymatic enantioselective synthesis of aminoacids3rd International Congress on Aminoacids, Aug 1993, Wien, Austria. ⟨10.1007/BF00806197⟩
Communication dans un congrès
istex
hal-02010087
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Synergistic Effects of Novel Naphthoquinone Derivatives Against Clinical Methicilin-Resistant Staphylococcus aureus StrainREncontres en Chimie Organique Biologique 18 (RECOB18), Mar 2022, Aussois, France.
Poster de conférence
hal-03700525
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Study of the bio monitoring potential of acclimated Tillandsia species in Occitanie for metal air pollutionNatural Products and Biocontrol 2022, Sep 2022, Perpignan, France
Poster de conférence
hal-03806423
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Synthesis and biological evaluations of new families of histidine kinases inhibitorsGSO-JMJC-JED2019, Oct 2019, Montpellier, France.
Poster de conférence
hal-02333120
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Trophic interactions between Pseudosphinx tetrio larvae and Allamanda catharticaCaribbean Science and Innovation Meeting 2019, Oct 2019, Pointe-à-Pitre (Guadeloupe), France
Poster de conférence
hal-02893707
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Design and synthesis of novel HLM 006474 derivatives.24th ISCB international conference-Frontier research in chemistry&biology interface., Jan 2018, JAIPUR, India
Poster de conférence
hal-01998366
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Improved synthesis, resolution, absolute configuration determination of HLM006474 enantiomerXXII International conférence on Organic synthesis (22-ICOS), Sep 2018, Florence, Italy
Poster de conférence
hal-02011288
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Synthesis of thiophene derivatives: Potential new inhibitors of histidine kinasesRencontres en Chimie Organique Biologique (Recob 17), Mar 2018, Aussois, France.
Poster de conférence
hal-01997587
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Synthesis of Novel Triazole Amino Acids Analogues of Natural Amino Acids20th European symposium on Organic Chemistry (ESOC), Jul 2017, Cologne, Germany
Poster de conférence
hal-02011261
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Rational design of potent histidine kinase inhibitors with antimicrobial activities.Experimental Biology meeting in San Diego, Apr 2016, San Diego, United States. The FASEB Journal, 30 (S1), pp.lb146-lb146, ⟨10.1096/fasebj.30.1_supplement.lb146⟩
Poster de conférence
hal-01998350
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Synthesis of triazole amino acids14th International Congress on Amino Acids, Peptides and Proteins, Aug 2015, Vienne, Austria
Poster de conférence
hal-01998273
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Design and synthesis of 1,4-disubstituted 1,2,3-triazole derivatives as Histidine Kinase inhibitor.77th Harden Conference: Two Component Signalling in Bacteria: Integrating Approaches and Science, Aug 2015, Warwickshire, United Kingdom
Poster de conférence
hal-01998338
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Rational design of potent histidine kinase inhibitors with antimicrobial activities8ème congrès international sur les microorganismes gram-positive, Jun 2015, Montecatini, Italy
Poster de conférence
hal-01998292
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Synthesis of ethynyl phenylalanineThe 5th European Chemistry Congress, Aug 2014, Istanbul, Turkey
Poster de conférence
hal-01998193
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Synthesis of ethynyl phenylalanine21ème journée de l’Institut de Recherche Pierre Fabre (IRPF) de chimie. Chambre de commerce et d’industrie de Castres, Sep 2014, Castres, France
Poster de conférence
hal-01998205
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Synthetic uses of serine, threonine and cysteineAmino Acid Derivatives : A Practical Approach, Ed. G. C. Barrett, The Practical Approach in Chemistry Series (Series Editors : L. M. Harwood, C. J. Moody), Oxford University Press, Dec. 1999, ISBN0198558538, 1999
Chapitre d'ouvrage
hal-02010084
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Synthetic uses of methionineAmino Acid Derivatives : A Practical Approach, Ed. G. C. Barrett, The Practical Approach in Chemistry Series (Series Editors : L. M. Harwood, C. J. Moody), Oxford University Press, Dec. 1999, ISBN0198558538., 1999
Chapitre d'ouvrage
hal-02010083
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A crosstalk between E2F1 and GLP-1 signaling pathways modulates insulin secretion2023
Pré-publication, Document de travail
hal-04365604
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Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs2023
Pré-publication, Document de travail
hal-04365611
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Special issue: Synthesis and Medicinal ChemistryAmino Acids, 29 (2), pp.79-79, 2005, ⟨10.1007/s00726-005-0236-3⟩
N°spécial de revue/special issue
istex
hal-02010122
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Special Issue: SynthesisAmino Acids, 24, pp.229-229, 2003, ⟨10.1007/s007260300001⟩
N°spécial de revue/special issue
istex
hal-02010114
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