Przybyłek Maciej

I. EDUCATION AND ACADEMIC DEGREES 1) A graduate of the Faculty of Technology and Chemical Engineering at the University of Technology and Life Science in Bydgoszcz (2010), field of study: Chemical Technology, field of specialization: Technology of Chemical Process. 2) Doctorate in Pharmacy at the Nicolaus Copernicus University (2016), PhD Thesis: "Studies on the orientation effect of crystallites and its application to cocrystal screening of selected pharmacologically active compounds" 3) Habilitation in Pharmacy at the Nicolaus Copernicus University (2024), "Experimental and theoretical studies of the solubility of selected pharmaceuticals and their affinity to other substances in the solid and liquid phase" II. PROFESSIONAL EXPERIENCE 1)December 2011 - October 2018: Assistant at Department of Physical Chemistry, Pharmacy Faculty, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń. 2) October 2018 - Present: Assistant Professor at Department of Physical Chemistry, Pharmacy Faculty, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń.
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Identifiants chercheurs

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Compétences

pharmacy physical pharmacy physical chemistry biomaterials environmental chemistry

Publications

Publications

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Navigating the Deep Eutectic Solvent Landscape: Experimental and Machine Learning Solubility Explorations of Syringic, p-Coumaric, and Caffeic Acids

Piotr Cysewski , Tomasz Jeliński , Maciej Przybyłek , Natalia Gliniewicz , Marcel Majkowski et al.

International Journal of Molecular Sciences, 2025, 26 (20), pp.10099. ⟨10.3390/ijms262010099⟩

Article dans une revue hal-05318657v1
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Data-Driven Classification of Solubility Space in Deep Eutectic Solvents: Deciphering Driving Forces Using PCA and K-Means Clustering

Piotr Cysewski , Maciej Przybyłek , Tomasz Jeliński

Molecules, 2025, 30 (23), pp.4563. ⟨10.3390/molecules30234563⟩

Article dans une revue hal-05388529v1
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Tribological effects of hyaluronic acid concentration on articular cartilage: pin-on-plate friction tests in porcine and osteoarthritic human tissue

Adam J Mazurkiewicz , Celina Pezowicz , Anna Nikodem , Maciej Przybyłek , Dominika Mazurkiewicz

Journal of Theoretical and Applied Mechanics, 2025, ⟨10.15632/jtam-pl/210752⟩

Article dans une revue hal-05318653v1
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Coconut Milk-Derived Bioactive Peptides as Multifunctional Agents Against Hyperglycemia, Oxidative Stress, and Glycation: An Integrated Experimental and Computational Study

Akshaya Simha Naganarasimha , Shashank M Patil , Ramith Ramu , Maciej Przybyłek , Piotr Bełdowski et al.

International Journal of Molecular Sciences, 2025, 27 (1), pp.360. ⟨10.3390/ijms27010360⟩

Article dans une revue hal-05435834v1
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From Molecular Interactions to Solubility in Deep Eutectic Solvents: Exploring Flufenamic Acid in Choline-Chloride- and Menthol-Based Systems

Piotr Cysewski , Tomasz Jeliński , Oliwia Kukwa , Maciej Przybyłek

Molecules, 2025, 30 (16), pp.3434. ⟨10.3390/molecules30163434⟩

Article dans une revue hal-05217022v1
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Identification and 3D modeling of bioactive peptides from Lactobacillus brevis RAMULAB49 protein hydrolysate with in silico ERK1 phosphorylation inhibition activity targeting diabetic nephropathy

Reshma Mary Martiz , Ramith Ramu , Hemalatha Nambisan , Ameer Suhail , Mohammad Raish et al.

PLoS ONE, 2025, 20 (9), pp.e0331192. ⟨10.1371/journal.pone.0331192⟩

Article dans une revue hal-05281859v1
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Exploration of the Solubility Hyperspace of Selected Active Pharmaceutical Ingredients in Choline-and Betaine-Based Deep Eutectic Solvents: Machine Learning Modeling and Experimental Validation

Piotr Cysewski , Tomasz Jeli , Maciej Przybyłek

Molecules, 2024, 29 (20), pp.4894. ⟨10.3390/molecules29204894⟩

Article dans une revue hal-04740525v1
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Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents

Piotr Cysewski , Tomasz Jeliński , Maciej Przybyłek

Molecules, 2024, 29 (8), pp.1743. ⟨10.3390/molecules29081743⟩

Article dans une revue hal-04543084v1
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Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen

Piotr Cysewski , Tomasz Jeliński , Maciej Przybyłek , Anna Mai , Julia Kułak

Molecules, 2024, 29 (10), pp.2296. ⟨10.3390/molecules29102296⟩

Article dans une revue hal-04575510v1
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Deep Eutectic Solvents as Agents for Improving the Solubility of Edaravone: Experimental and Theoretical Considerations

Tomasz Jeliński , Maciej Przybyłek , Magdalena Mianowana , Kinga Misiak , Piotr Cysewski

Molecules, 2024, 29 (6), pp.1261. ⟨10.3390/molecules29061261⟩

Article dans une revue hal-04543106v1
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Effect of Nanohydroxyapatite on Silk Fibroin-Chitosan Interactions-Molecular Dynamics Study

Maciej Przybył , Anna Tuwalska , Damian Ledziński , Sandra Śmigiel , Alina Sionkowska et al.

Applied Sciences, 2024, 14 (10), pp.4131. ⟨10.3390/app14104131⟩

Article dans une revue hal-04574093v1
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Tuning Ferulic Acid Solubility in Choline-Chloride- and Betaine-Based Deep Eutectic Solvents: Experimental Determination and Machine Learning Modeling

Tomasz Jeliński , Maciej Przybyłek , Rafal Rozalski , Karolina Romanek , Daniel Wielewski et al.

Molecules, 2024, 29 (16), pp.3841. ⟨10.3390/molecules29163841⟩

Article dans une revue hal-04671140v1
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Molecular Insights into the Interactions Between Human Serum Albumin and Phospholipid Membranes

Maciej Przybyłek , Piotr Bełdowski , Zbigniew Lutowski , Damian Ledziński , Adam Mazurkiewicz et al.

Applied Sciences, 2024, 14 (24), pp.11753. ⟨10.3390/app142411753⟩

Article dans une revue hal-04843734v1
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Exploring the Solubility Limits of Edaravone in Neat Solvents and Binary Mixtures: Experimental and Machine Learning Study

Maciej Przybyłek , Tomasz Jeliński , Magdalena Mianowana , Kinga Misiak , Piotr Cysewski

Molecules, 2023, 28 (19), pp.6877. ⟨10.3390/molecules28196877⟩

Article dans une revue hal-04223421v1
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Intermolecular Interactions as a Measure of Dapsone Solubility in Neat Solvents and Binary Solvent Mixtures

Piotr Cysewski , Maciej Przybyłek , Tomasz Jeliński

Materials, 2023, 16 (18), pp.6336. ⟨10.3390/ma16186336⟩

Article dans une revue hal-04215566v1
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Collagen Type II-Chitosan Interactions as Dependent on Hydroxylation and Acetylation Inferred from Molecular Dynamics Simulations

Maciej Przybyłek , Piotr Bełdowski , Florian Wieland , Piotr Cysewski , Alina Sionkowska Article dans une revue hal-03912638v1
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Molecular dynamics simulations of the affinity of chitin and chitosan for collagen: the effect of pH and the presence of sodium and calcium cations

Maciej Przybyłek , Piotr Bełdowski

Progress on Chemistry and Application of Chitin and its Derivatives, 2023, 28, pp.136-150. ⟨10.15259/PCACD.28.013⟩

Article dans une revue hal-04231879v1
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Solubility Characteristics of Acetaminophen and Phenacetin in Binary Mixtures of Aqueous Organic Solvents: Experimental and Deep Machine Learning Screening of Green Dissolution Media

Piotr Cysewski , Tomasz Jeliński , Maciej Przybyłek , Wiktor Nowak , Michał Olczak Article dans une revue hal-03903876v1
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New Insights into Thermodynamics of Solutes in Neat and Complex Solvents

Piotr Cysewski , Tomasz Jeliński , Maciej Przybyłek Article dans une revue hal-03780993v1
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Application of COSMO-RS-DARE as a Tool for Testing Consistency of Solubility Data: Case of Coumarin in Neat Alcohols

Piotr Cysewski , Tomasz Jeli , Maciej Przybyłek

Molecules, 2022, 27 (16), pp.5274. ⟨10.3390/molecules27165274⟩

Article dans une revue hal-03753795v1
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Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study

Piotr Bełdowski , Maciej Przybyłek , Ali Sionkowska , Piotr Cysewski , Magdalena Gadomska et al.

Materials, 2022, 15 (2), pp.463. ⟨10.3390/ma15020463⟩

Article dans une revue hal-03517990v1
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Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility

Piotr Cysewski , Maciej Przybyłek , Rafal Rozalski

Materials, 2021, ⟨10.3390/ma14205915⟩

Article dans une revue hal-03372170v1
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Albumin–Hyaluronan Interactions: Influence of Ionic Composition Probed by Molecular Dynamics

Piotr Bełdowski , Maciej Przybyłek , Przemysław Raczyński , Andra Dedinaite , Krzysztof Górny et al.

International Journal of Molecular Sciences, 2021, 22 (22), pp.12360. ⟨10.3390/ijms222212360⟩

Article dans une revue hal-03431920v1
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Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents

Maciej Przybyłek , Anna Kowalska , Natalia Tymorek , Tomasz Dziaman , Piotr Cysewski

Molecules, 2021, 26 (13), pp.4078. ⟨10.3390/molecules26134078⟩

Article dans une revue hal-03278334v1

Studies on the solid-liquid equilibria and intermolecular interactions Urea binary mixtures with Sulfanilamide and Sulfacetamide

Maciej Przybyłek , Patrycja Walczak , Dorota Ziółkowska , Izabela Grela , Piotr Cysewski

The Journal of Chemical Thermodynamics, 2021, 153, pp.106308. ⟨10.1016/j.jct.2020.106308⟩

Article dans une revue hal-02954736v1
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Thermodynamics and Intermolecular Interactions of Nicotinamide in Neat and Binary Solutions: Experimental Measurements and COSMO-RS Concentration Dependent Reactions Investigations

Piotr Cysewski , Maciej Przybyłek , Anna Kowalska , Natalia Tymorek

International Journal of Molecular Sciences, 2021, 22 (14), pp.7365. ⟨10.3390/ijms22147365⟩

Article dans une revue hal-03283187v1
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Solvent Screening for Solubility Enhancement of Theophylline in Neat, Binary and Ternary NADES Solvents: New Measurements and Ensemble Machine Learning

Piotr Cysewski , Tomasz Jeliński , Patryk Cymerman , Maciej Przybyłek

International Journal of Molecular Sciences, 2021, 22 (14), pp.7347. ⟨10.3390/ijms22147347⟩

Article dans une revue hal-03284285v1

Solubility of sulfanilamide in binary solvents containing water: Measurements and prediction using Buchowski-Ksiazczak solubility model

Tomasz Jeliński , Natalia Bugalska , Kinga Koszucka , Maciej Przybyłek , Piotr Cysewski

Journal of Molecular Liquids, 2020, 319, pp.114342. ⟨10.1016/j.molliq.2020.114342⟩

Article dans une revue hal-02943573v1
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Application 2D Descriptors and Artificial Neural Networks for Beta-Glucosidase Inhibitors Screening

Maciej Przybyłek Article dans une revue hal-03070564v1
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Application of Multivariate Adaptive Regression Splines (MARSplines) for Predicting Hansen Solubility Parameters Based on 1D and 2D Molecular Descriptors Computed from SMILES String

Maciej Przybyłek , Tomasz Jeliński , Piotr Cysewski

Journal of Chemistry , 2019, ⟨10.1155/2019/9858371⟩

Article dans une revue hal-01977664v1
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The use of fast molecular descriptors and artificial neural networks approach in organochlorine compounds electron ionization mass spectra classification

Maciej Przybyłek , Waldemar Studziński , Alicja Gackowska , Jerzy Gaca

Environmental Science and Pollution Research, 2019, 26 (27), pp.28188-28201. ⟨10.1007/s11356-019-05968-4⟩

Article dans une revue hal-02318325v1
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Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin

Tomasz Jeliński , Maciej Przybyłek , Piotr Cysewski

Pharmaceutical Research, 2019, 36 (8), ⟨10.1007/s11095-019-2643-2⟩

Article dans une revue hal-02184283v1
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Predicting Value of Binding Constants of Organic Ligands to Beta-Cyclodextrin: Application of MARSplines and Descriptors Encoded in SMILES String

Piotr Cysewski , Maciej Przybyłek

Symmetry, 2019, 11 (7), pp.922. ⟨10.3390/sym11070922⟩

Article dans une revue hal-02184280v1

Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems: experimental and theoretical investigations

Tomasz Jeliński , Maciej Przybyłek , Piotr Cysewski

Drug Development and Industrial Pharmacy, 2019, ⟨10.1080/03639045.2019.1597104⟩

Article dans une revue hal-02073396v1

Distinguishing Cocrystals from Simple Eutectic Mixtures: Phenolic Acids as Potential Pharmaceutical Coformers

Maciej Przybyłek , Piotr Cysewski

Crystal Growth & Design, 2018, 18 (6), pp.3524-3534. ⟨10.1021/acs.cgd.8b00335⟩

Article dans une revue hal-01783502v1
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Selection of effective cocrystals former for dissolution rate improvement of active pharmaceutical ingredients based on lipoaffinity index

Piotr Cysewski , Maciej Przybyłek

European Journal of Pharmaceutical Sciences, 2017, 107, pp.87-96. ⟨10.1016/j.ejps.2017.07.004⟩

Article dans une revue hal-01773096v1
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Studies on the formation of formaldehyde during 2-ethylhexyl 4-(dimethylamino)benzoate demethylation in the presence of reactive oxygen and chlorine species

Waldemar Studziński , Alicja Gackowska , Maciej Przybyłek , Jerzy Gaca

Environmental Science and Pollution Research, 2017, 24 (9), pp.8049-8061. ⟨10.1007/s11356-017-8477-8⟩

Article dans une revue hal-01773002v1

Applicability of Phenolic Acids as Effective Enhancers of Cocrystal Solubility of Methylxanthines

Maciej Przybyłek , Dorota Ziółkowska , Karina Mroczyńska , Piotr Cysewski

Crystal Growth & Design, 2017, 17 (4), pp.2186 - 2193. ⟨10.1021/acs.cgd.7b00121⟩

Article dans une revue hal-01773089v1

Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea

Maciej Przybyłek , Dorota Ziółkowska , Mirosław Kobierski , Karina Mroczyńska , Piotr Cysewski

Journal of Crystal Growth, 2016, 433, pp.128 - 138. ⟨10.1016/j.jcrysgro.2015.10.015⟩

Article dans une revue hal-01773010v1
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Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite

Alicja Gackowska , Maciej Przybyłek , Waldemar Studziński , Jerzy Gaca

Environmental Science and Pollution Research, 2016, 23 (2), pp.1886-1897. ⟨10.1007/s11356-015-5444-0⟩

Article dans une revue hal-01772993v1

Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids

Maciej Przybyłek , Dorota Ziółkowska , Karina Mroczyńska , Piotr Cysewski

European Journal of Pharmaceutical Sciences, 2016, 85, pp.132 - 140. ⟨10.1016/j.ejps.2016.02.010⟩

Article dans une revue hal-01773016v1
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Exploring the cocrystallization potential of urea and benzamide

Piotr Cysewski , Maciej Przybyłek , Dorota Ziółkowska , Karina Mroczyńska

Journal of Molecular Modeling, 2016, 22 (5), pp.103. ⟨10.1007/s00894-016-2964-6⟩

Article dans une revue hal-01773091v1
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On the origin of surface imposed anisotropic growth of salicylic and acetylsalicylic acids crystals during droplet evaporation

Maciej Przybyłek , Piotr Cysewski , Maciej Pawelec , Dorota Ziółkowska , Mirosław Kobierski

Journal of Molecular Modeling, 2015, 21 (3), pp.49. ⟨10.1007/s00894-015-2599-z⟩

Article dans une revue hal-01772925v1
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On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method

Piotr Cysewski , Maciej Przybyłek , Tomasz Miernik , Mirosław Kobierski , Dorota Ziółkowska

Structural Chemistry, 2015, 26 (3), pp.705 - 712. ⟨10.1007/s11224-014-0528-x⟩

Article dans une revue hal-01773094v1

Experimental and theoretical studies on the photodegradation of 2-ethylhexyl 4-methoxycinnamate in the presence of reactive oxygen and chlorine species

Alicja Gackowska , Maciej Przybyłek , Waldemar Studziński , Jerzy Gaca

Central European Journal of Chemistry, 2014, 12 (5), pp.612 - 623. ⟨10.2478/s11532-014-0522-6⟩

Article dans une revue hal-01773085v1

Reaction of aniline with ammonium persulphate and concentrated hydrochloric acid: Experimental and DFT studies

Maciej Przybyłek , Jerzy Gaca

Chemical Papers, 2012, 66 (7), pp.699-708. ⟨10.2478/s11696-012-0163-1⟩

Article dans une revue hal-01773005v1

Color prediction from first principle quantum chemistry computations: a case of alizarin dissolved in methanol

Piotr Cysewski , Tomasz Jeliński , Maciej Przybyłek , Aleksander Shyichuk

New Journal of Chemistry, 2012, 36 (9), ⟨10.1039/c2nj40327g⟩

Article dans une revue hal-01773088v1