Rafael ARGUELLO

90 %
Libre accès
62
Documents
Affiliations actuelles
  • Centre National de la Recherche Scientifique (CNRS)
  • Institut National de la Santé et de la Recherche Médicale (INSERM)
  • Aix Marseille Université (AMU)
  • Centre d'Immunologie de Marseille - Luminy (CIML)
Identifiants chercheurs

Publications

Publications

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VPS34-IN1 potentiates STING-dependent activation in human CAL-1 cells

Paulo Antas , Mariana D Machado , Fátima Leite-Pinheiro , Daniela Barros , Carlota Ramalhinho et al.

Cellular and Molecular Biology Letters, 2026, Online ahead of print. ⟨10.1186/s11658-025-00841-4⟩

Article dans une revue hal-05477288v1
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Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation

Daniela Barros , Beatriz H Ferreira , Paulina Garcia-Gonzalez , Francesco Carbone , Marine Luka et al.

Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (21), pp.e2421258122. ⟨10.1073/pnas.2421258122⟩

Article dans une revue hal-05348432v1
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Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Dominic Denk , Anurag Singh , Herbert Kasler , Davide D’amico , Julia Rey et al.

Nature Aging, 2025, 5 (11), pp.2309-2322. ⟨10.1038/s43587-025-00996-x⟩

Article dans une revue hal-05515256v1
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Single-cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions

Laila Karra , Anna-Marie Finger , Lauren Shechtman , Milana Krush , Rita Meng et al. Article dans une revue hal-05505727v1
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The metabolic profile of circulating plasmacytoid dendritic cells from patients with systemic sclerosis

Beatriz Ferreira , Carolina Mazeda , Eduardo Dourado , João Simões , Ana Rita Prata et al.

Arthritis Research & Therapy, 2025, 27 (1), pp.35. ⟨10.1186/s13075-025-03500-3⟩

Article dans une revue hal-05348525v1
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Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication

Carolina Jardim , Marta Bica , Mariana Reis-Sobreiro , Afonso Teixeira da Mota , Raquel Lopes et al.

Cancer Immunology Research, 2025, 13 (8), pp.1207-1225. ⟨10.1158/2326-6066.CIR-24-0797⟩

Article dans une revue hal-05416980v1
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Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation

Rodrigo de Oliveira Formiga , Qing Li , Yining Zhao , Márcio Augusto Campos Ribeiro , Perle Guarino-Vignon et al.

Cell Host & Microbe, 2025, 33 (11), pp.1855-1872.e10. ⟨10.1016/j.chom.2025.09.009⟩

Article dans une revue hal-05311416v1
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Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions

Yu-San Kao , Mario Lauterbach , Aleksandra Lopez Krol , Ute Distler , Gloria Janet Godoy et al.

Nature Metabolism, 2025, 7 (5), pp.966 - 984. ⟨10.1038/s42255-025-01276-z⟩

Article dans une revue hal-05417010v1
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Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation

Qing Li , Rodrigo de Oliveira Formiga , Virginie Puchois , Laura Creusot , Ahmad Haidar Ahmad et al.

Nature Metabolism, 2025, 7 (12), pp.2510-2530. ⟨10.1038/s42255-025-01396-6⟩

Article dans une revue pasteur-05390470v1
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Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer

Karen Slattery , Cong-Hui Yao , Eimear Mylod , John Scanlan , Barry Scott et al.

Science Immunology, 2025, 10 (107), pp.eadr4795. ⟨10.1126/sciimmunol.adr4795⟩

Article dans une revue hal-05417026v1
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Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis

J Tucker Andrews , Zijing Zhang , G V R Krishna Prasad , Fischer Huey , Evgeniya V Nazarova et al.

Mucosal Immunology, 2024, 17 (5), pp.825 - 842. ⟨10.1016/j.mucimm.2024.05.007⟩

Article dans une revue hal-04780933v1

VPS34-IN1 inhibits cap-mediated translation and synergizes with STING to drive type-I IFN expression in human plasmacytoid DCs

Paulo Antas , Mariana Machado , Fátima Leite-Pinheiro , Daniela Barros , Carlota Ramalhinho et al. Article dans une revue hal-04793449v1
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Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling

Alexia Borelli , Jérémy C Santamaria , Cloé Zamit , Cécile Apert , Jessica Chevallier et al.

Nature Communications, 2024, 15, pp.6976. ⟨10.1038/s41467-024-51164-5⟩

Article dans une revue hal-04780863v1
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Immunosenescence and vaccine efficacy revealed by immunometabolic analysis of SARS-CoV-2-specific cells in multiple sclerosis patients

Sara de Biasi , Domenico Lo Tartaro , Anita Neroni , Moritz Rau , Nikolaos Paschalidis et al.

Nature Communications, 2024, 15, ⟨10.1038/s41467-024-47013-0⟩

Article dans une revue hal-04743975v1
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Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia

Dorian Forte , Roberto Maria Pellegrino , Paolo Falvo , Paulina Garcia-Gonzalez , Husam B R Alabed et al.

Nature Communications, 2024, 15 (1), pp.10878. ⟨10.1038/s41467-024-55231-9⟩

Article dans une revue hal-05417047v1
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Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

Mariano Maio , Joaquina Barros , Marine Joly , Zoï Vahlas , José Luis Marín Franco et al.

eLife, 2024, 12 (8), pp.e1011559. ⟨10.7554/eLife.89319⟩

Article dans une revue hal-04738385v1
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Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice

Alexandre Gallerand , Bastien Dolfi , Marion I Stunault , Zakariya Caillot , Alexia Castiglione et al.

Nature Communications, 2024, 15, ⟨10.1038/s41467-024-53267-5⟩

Article dans une revue hal-04780837v1
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Defective mitochondria remodelling in B cells leads to an aged immune response

Marta Iborra-Pernichi , Jonathan Ruiz García , María Velasco de la Esperanza , Belén S Estrada , Elena R Bovolenta et al.

Nature Communications, 2024, 15 (1), pp.2569. ⟨10.1038/s41467-024-46763-1⟩

Article dans une revue hal-04743987v1

Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation

Daniela Barros , Beatriz Ferreira , Paulina Garcia-Gonzalez , Francesco Carbone , Marine Luka et al. Article dans une revue hal-04793368v1
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Immuno-metabolic dendritic cell vaccine signatures associate with overall survival in vaccinated melanoma patients

Juraj Adamik , Paul V Munson , Deena M Maurer , Felix J Hartmann , Sean C Bendall et al.

Nature Communications, 2023, 14 (1), pp.7211. ⟨10.1038/s41467-023-42881-4⟩

Article dans une revue hal-04534383v1
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Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis

Sevgi Kostel Bal , Sarah Giuliani , Jana Block , Peter Repiscak , Christoph Hafemeister et al.

Blood, 2023, 142 (9), pp.827-845. ⟨10.1182/blood.2022018303⟩

Article dans une revue hal-04309057v1
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Immuno-metabolic dendritic cell vaccine signatures associate with overall survival in vaccinated melanoma patients

Juraj Adamik , Paul V Munson , Deena M Maurer , Felix J Hartmann , Sean C Bendall et al.

Nature Communications, 2023, 14, pp.7211. ⟨10.1038/s41467-023-42881-4⟩

Article dans une revue hal-04780978v1
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Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias

Julian Swatler , Domenico Lo Tartaro , Rebecca Borella , Marta Brewinska-Olchowik , Annamaria Paolini et al.

Haematologica, 2023, 108 (3), pp.909-916. ⟨10.3324/haematol.2022.281713⟩

Article dans une revue hal-04239656v1
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Light-inducible T cell engagers trigger, tune and shape the activation of primary T cells

Morgane Jaeger , Amandine Anastasio , Léa Chamy , Sophie Brustlein , Renaud Vincentelli et al.

Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (39), pp.e2302500120. ⟨10.1073/pnas.2302500120⟩

Article dans une revue hal-03775201v2
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OXPHOS promotes apoptotic resistance and cellular persistence in T <sub>H</sub> 17 cells in the periphery and tumor microenvironment

Hanna S Hong , Nneka E Mbah , Mengrou Shan , Kristen Loesel , Lin Lin et al.

Science Immunology, 2023, 7, ⟨10.1126/sciimmunol.abm8182⟩

Article dans une revue hal-04062465v1
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An integrated toolbox to profile macrophage immunometabolism

Sanne G.S. Verberk , Kyra de Goede , Friederike Gorki , Xanthe A.M.H. van Dierendonck , Rafael J Argüello et al.

Cell Reports Methods, 2022, 2 (4), pp.100192. ⟨10.1016/j.crmeth.2022.100192⟩

Article dans une revue hal-03867132v1
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ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection

Dan Corral , Alison Charton , Maria Z Krauss , Eve Blanquart , Florence Levillain et al.

Cell Reports, 2022, 39 (3), pp.110715. ⟨10.1016/j.celrep.2022.110715⟩

Article dans une revue hal-03951977v1
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An integrated toolbox to profile (macrophage) immunometabolism

Sanne G.S. Verberk , Kyra de Goede , Friederike Gorki , Xanthe A.M.H. van Dierendonck , Rafael J Argüello et al.

Cell Reports Methods, 2022, 2 (4), pp.100192. ⟨10.1016/j.crmeth.2022.100192⟩

Article dans une revue hal-03856610v1

Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study

Carine Jiguet-Jiglaire , Sebastien Boissonneau , Emilie Denicolai , Victoria Hein , Romain Lasseur et al.

Acta Neuropathologica Communications, 2022, 10 (1), pp.1. ⟨10.1186/s40478-021-01305-4⟩

Article dans une revue hal-03549379v1
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Discovering dominant tumor immune archetypes in a pan-cancer census

Alexis Combes , Bushra Samad , Jessica Tsui , Nayvin Chew , Peter Yan et al.

Cell, 2022, 185 (1), pp.184-203.e19. ⟨10.1016/j.cell.2021.12.004⟩

Article dans une revue hal-03549512v1
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Unravelling the sex-specific diversity and functions of adrenal gland macrophages

Bastien Dolfi , Alexandre Gallerand , Maria M Firulyova , Yingzheng Xu , Johanna Merlin et al.

Cell Reports, 2022, 39, ⟨10.1016/j.celrep.2022.110949⟩

Article dans une revue hal-03794801v1
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Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells

Juraj Adamik , Paul V Munson , Felix J Hartmann , Alexis J Combes , Philippe Pierre et al.

Nature Communications, 2022, 13, ⟨10.1038/s41467-022-32849-1⟩

Article dans une revue hal-03817576v1
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Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

Allison K Maher , Katie L Burnham , Emma M Jones , Michelle M H Tan , Rocel C Saputil et al.

Nature Communications, 2022, 13, ⟨10.1038/s41467-022-35638-y⟩

Article dans une revue hal-03959998v1

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

Adriana Mujal , Alexis Combes , Arjun Rao , Mikhail Binnewies , Bushra Samad et al.

Cancer Immunology Research, 2022, 10 (4), pp.403-419. ⟨10.1158/2326-6066.CIR-21-0588⟩

Article dans une revue hal-04027478v1

Unravelling the sex-specific diversity and functions of adrenal gland macrophages

Bastien Dolfi , Alexandre Gallerand , Maria Firulyova , Yingzheng Xu , Johanna Merlin et al.

Cell Reports, 2022, 39 (11), pp.110949. ⟨10.1016/j.celrep.2022.110949⟩

Article dans une revue hal-03858946v1
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Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4

Andreia Mendes , Julien P Gigan , Christian Rodriguez Rodrigues , Sébastien A Choteau , Doriane Sanseau et al.

Life Science Alliance, 2021, 4 (2), pp.e202000865. ⟨10.26508/lsa.202000865⟩

Article dans une revue hal-03121710v1

Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

Claudie Bosc , Estelle Saland , Aurélie Bousard , Noémie Gadaud , Marie Sabatier et al.

Nature Cancer, 2021, 2 (11), pp.1204-1223. ⟨10.1038/s43018-021-00264-y⟩

Article dans une revue hal-03565962v1
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Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Noella Lopes , Claire Mcintyre , Stefania Martin , Mathilde Raverdeau , Nital Sumaria et al.

Nature Immunology, 2021, 22 (2), pp.179-192. ⟨10.1038/s41590-020-00848-3⟩

Article dans une revue hal-03121669v1
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SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

Rafael J Argüello 1∞ , Rafael Argüello , Alexis J Combes , Remy Char , Julien-Paul Gigan et al.

Cell Metabolism, 2020, 32 (6), pp.1063-1075.e7. ⟨10.1016/j.cmet.2020.11.007⟩

Article dans une revue hal-03082094v1

At the crossway of ER-stress and proinflammatory responses

Marisa Reverendo , Andreia Mendes , Rafael Argüello , Evelina Gatti , Philippe Pierre

FEBS Journal, 2019, 286 (2), pp.297-310. ⟨10.1111/febs.14391⟩

Article dans une revue hal-03082823v1
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Polymerase III transcription is necessary for T cell priming by dendritic cells

Marisa Reverendo , Rafael J Argüello , Christine Polte , Jan Valečka , Voahirana Camosseto et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019, ⟨10.1073/pnas.1904396116⟩

Article dans une revue hal-02363598v1

Polymerase III transcription is necessary for T cell priming by dendritic cells

Marisa Reverendo , Rafael Argüello , Christine Polte , Jan Valečka , Voahirana Camosseto et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (45), pp.22721-22729. ⟨10.1073/pnas.1904396116⟩

Article dans une revue hal-03082832v1

At the crossway of ER-stress and proinflammatory responses

Marisa Reverendo , Andreia Mendes , Rafael J. Arguello , Evelina Gatti , Philippe Pierre

FEBS Journal, 2019, 286 (2, SI), pp.297-310. ⟨10.1111/febs.14391⟩

Article dans une revue hal-02359462v1
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SunRiSE – measuring translation elongation at single-cell resolution by means of flow cytometry

Rafael J Argüello , Marisa Reverendo , Andreia Mendes , Voahirana Camosseto , Adrian G Torres et al.

Journal of Cell Science, 2018, 131 (10), pp.jcs214346. ⟨10.1242/jcs.214346⟩

Article dans une revue hal-01982340v1
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BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

Alexis Combes , Voahirana Camosseto , Prudence N’guessan , Rafael J Argüello , Julie Mussard et al.

Nature Communications, 2017, 8 (1), pp.913. ⟨10.1038/s41467-017-00695-1⟩

Article dans une revue hal-03545468v1
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Protein synthesis inhibition and GADD34 control IFN‐β heterogeneous expression in response to dsRNA

Alexandre Dalet , Rafael J Argüello , Alexis Combes , Lionel Spinelli , Sebastien Jaeger et al.

EMBO Journal, 2017, 36 (6), pp.761 - 782. ⟨10.15252/embj.201695000⟩

Article dans une revue hal-01476255v1

tRNAs: new regularors of immunity?

R. J. Arguello , M. Reverendo , S. Terawaki , A. Combes , T. P. Vu-Manh et al.

European Journal of Immunology, 2016, 46 (1, SI), pp.787-788

Article dans une revue hal-01438141v1

Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation

Rafael J. Arguello , Marisa Reverendo , Evelina Gatti , Philippe Pierre

Immunological Reviews, 2016, 272 (1, SI), pp.28-38. ⟨10.1111/imr.12427⟩

Article dans une revue istex hal-01438152v1

Energetic metabolism profiling with single cell resolution

Rafael J Argüello

54th Annual meeting of the Society for Leukocyte Biology “Immunometabolism: Fueling the flame of Aging, Cancer and Immunity”, Jun 2021, London, United Kingdom

Communication dans un congrès hal-03451766v1

Profiling energetic metabolism and epigenetics by Flow cyometry

Rafael J Argüello

4th Edition: Metabolism and Cancer. https://www.metabolism-cancer.com/program/, May 2021, Bordeaux, France

Communication dans un congrès hal-03451780v1
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IMMUNO-METABOLIC SIGNATURES OF DENDRITIC CELLS ASSOCIATE WITH T-CELL RESPONSES IN MELANOMA PATIENTS

Juraj Adamik , Deena Maurer , Paul Munson , Alexis Combes , Philippe Pierre et al.

SICT, Nov 2020, Los Angeles, United States. pp.A325 - A325, ⟨10.1136/jitc-2020-sitc2020.0299⟩

Communication dans un congrès hal-03451694v1

Measuring the Metabolic State of Tissue-Resident Macrophages via SCENITH

Andrea Vogel , Paulina García González , Rafael J Argüello

Tissue-Resident Macrophages, 2713, Springer US, pp.363-376, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3437-0_25⟩

Chapitre d'ouvrage hal-04780672v1
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Connecting mitochondrial metabolism and mitotic fidelity to control vulnerability of high grade serous ovarian cancer patients to taxane-based chemotherapy

Hadia Moindjie , Morgane Morin , Evanthia Pangou , Diego Chianese , Cynthia Seiler et al.

2026

Pré-publication, Document de travail (preprint/prepublication) hal-05462261v1
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Lipid-mediated GPR32 signaling reprograms macrophage metabolism to impair anti-tuberculous immunity

Joaquina Barros , Mariano Maio , Martín Manuel Ledesma , María Emilia Boix , Natacha Faivre et al.

2025

Pré-publication, Document de travail hal-05387674v1
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Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Sara Alonso , Harsimran Kaur , Luo Jia , Mai-Uyen Nguyen , Alyssa Laguerta et al.

2025

Pré-publication, Document de travail hal-05417036v1
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Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma

Julien Gigan , Paulina Garcia-Gonzalez , Lou Galliot , Alexandre Reynaud , Yoan Ghaffar et al.

2024

Pré-publication, Document de travail (preprint/prepublication) hal-04791295v1
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“Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR) reveals bortezomib resistance mechanisms in Multiple Myeloma”

Julien P Gigan , Paulina Garcia-Gonzalez , Lou Galliot , Alexandre Reynaud , Yoan Ghaffar et al.

2025

Pré-publication, Document de travail hal-05348771v1

Metabolically Primed Multipotent Hematopoietic Progenitors Fuel Innate Immunity

Jason Cosgrove , Anne-Marie Lyne , Ildefonso Rodriguez , Vincent Cabeli , Cecile Conrad et al.

2023

Pré-publication, Document de travail hal-04286084v1

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

Rafael J Argüello , Alexis Combes , Bushra Samad , Jessica Tsui , Nayvin Chew et al.

2021

Pré-publication, Document de travail hal-03407890v1
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Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection

Dan Corral , Alison Charton , Maria Z Krauss , Eve Blanquart , Florence Levillain et al.

2021

Pré-publication, Document de travail hal-03451521v1
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Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

Adriana M Mujal , Alexis J Combes , Arjun R Rao , Mikhail Binnewies , Bushra Samad et al.

2021

Pré-publication, Document de travail hal-03451508v3
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A toolbox to profile immunometabolism tested in macrophages

Sanne G S Verberk , Kyra E de Goede , Friederike S Gorki , Xanthe a M H van Dierendonck , Rafael J Argüello et al.

2021

Pré-publication, Document de travail hal-03451467v1