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Reine Nehmé

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  • Institut de Chimie Organique et Analytique (ICOA)
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Publications

Publications

Microscale Thermophoresis for Thermodynamic Analysis: A Proof-of-Concept Study on LIMK Inhibitors

Solweig Chartier , Bérengère Claude , Rouba Nasreddine , Pierre Soule , Alexandra Launay et al.

Journal of Molecular Biology, 2026, 438 (5), pp.169621. ⟨10.1016/j.jmb.2025.169621⟩

Article dans une revue (article de synthèse) hal-05517956v1

LIM kinase/inhibitor binding study in cell lysates using microscale thermophoresis in the red spectrum

Solweig Chartier , Mélanie Rapeto , Rouba Nasreddine , Elodie Villalonga-Rosso , Bérengère Claude et al.

Analytica Chimica Acta, 2026, 1382, pp.344837. ⟨10.1016/j.aca.2025.344837⟩

Article dans une revue hal-05347896v1
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Molecular recognition of fungal methylated glucosylceramides by ETD151 defensin

Ons Kharrat , Françoise Paquet , Rouba Nasreddine , Jean-Baptiste Madinier , Reine Nehmé et al.

Journal of Biological Chemistry, 2025, 301 (9), pp.110587. ⟨10.1016/j.jbc.2025.110587⟩

Article dans une revue hal-05250295v1
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Using CE to confirm the activity of fluorescent miRFP670-LIMK1 protein produced for MST assays directly in cell lysate

Solweig Chartier , Bérengère Claude , Rouba Nasreddine , Alexandra Launay , Marion Martins et al.

Analytica Chimica Acta, 2025, 1360, pp.344145. ⟨10.1016/j.aca.2025.344145⟩

Article dans une revue hal-05304644v1

The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms

Ons Kharrat , Yoshiki Yamaryo-Botté , Rouba Nasreddine , Sébastien Voisin , Thomas Aumer et al.

Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (7), pp.e2415524122. ⟨10.1073/pnas.2415524122⟩

Article dans une revue hal-05304638v1
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Impacts of Tween-20, Glycerol, and Trehalose on Hyaluronidase Activity: Insights from Microscale Thermophoresis and Capillary Electrophoresis

Rouba Nasreddine , Josipa Cecić Vidoš , Alexandra Launay , Reine Nehmé

Molecules, 2025, 30 (19), pp.4008. ⟨10.3390/molecules30194008⟩

Article dans une revue hal-05304634v1

A novel green reducing agent for the synthesis of chromium oxide nanoparticles (Cr2O3 NPs) based on saffron by-products: Characterization and antioxidant activity

Zineb Khadfy , Rachid Mamouni , S.M. Jadouali , Hajar Atifi , Nabil Saffaj et al.

Materials Science and Engineering: B, 2024, 305, pp.117415. ⟨10.1016/j.mseb.2024.117415⟩

Article dans une revue hal-04758110v1

Glycolipid and Lipopeptide Biosurfactants: Structural Classes and Characterization—Rhamnolipids as a Model

Nadin Darwiche , Christelle Dufresne , Agnès Chartier , Bérengère Claude , Cyril Colas et al.

Critical Reviews in Analytical Chemistry, 2024, pp.1-21. ⟨10.1080/10408347.2024.2441428⟩

Article dans une revue hal-05304648v1

A novel natural reducing agent for the preparation of cerium oxide nanoparticles based on the saffron by-product: Characterization, antioxidant and antibacterial activity for nutritional applications

Zineb Khadfy , Rachid Mamouni , Si Mohamed Jadouali , Hajar Atifi , Nabil Saffaj et al.

Nano-Structures & Nano-Objects, 2024, 40, pp.101381. ⟨10.1016/j.nanoso.2024.101381⟩

Article dans une revue hal-04744157v1

Nutraceutical Capacities of Extracts from the Invasive Plants Ambrosia Artemisiifolia and Solidago Canadensis

Vanille Quinty , Rouba Nasreddine , Cyril Colas , Alexandra Launay , Reine Nehmé et al.

SSRN Electronic Journal, 2023, ⟨10.2139/ssrn.4447346⟩

Article dans une revue hal-04758340v1

Nutraceutical and cosmetic applications of bioactive compounds of Saffron (Crocus Sativus L.) stigmas and its by-products

Zineb Khadfy , Hajar Atifi , Rachid Mamouni , Si Mohamed Jadouali , Agnes Chartier et al.

South African Journal of Botany, 2023, 163, pp.250-261. ⟨10.1016/j.sajb.2023.10.058⟩

Article dans une revue hal-04758127v1
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Capillary electrophoresis for enzyme-based studies: Applications to lipases and kinases

Ghassan Al Hamoui Dit Banni , Reine Nehmé

Journal of Chromatography A, 2022, 1661, pp.462687. ⟨10.1016/j.chroma.2021.462687⟩

Article dans une revue hal-03706495v1
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Biosurfactant-Producing Mucor Strains: Selection, Screening, and Chemical Characterization

Mélanie Chotard , Jérôme Mounier , Raissa Meye , Carole Padel , Bérengère Claude et al.

Advances in Applied Microbiology, 2022, 2 (1), pp.248-259. ⟨10.3390/applmicrobiol2010018⟩

Article dans une revue hal-04758143v1
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The myrosinase-glucosinolate system to generate neoglycoproteins: A case study targeting mannose binding lectins

Giuliano Cutolo , Blanka Didak , Josip Tomas , Benoit Roubinet , Pierre Lafite et al.

Carbohydrate Research, 2022, 516, pp.108562. ⟨10.1016/j.carres.2022.108562⟩

Article dans une revue hal-04645367v1
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Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study

Blanca López-Méndez , Bruno Baron , Chad Brautigam , Thomas Jowitt , Stefan Knauer et al.

European Biophysics Journal, 2021, 50 (3-4), pp.411-427. ⟨10.1007/s00249-021-01532-6⟩

Article dans une revue hal-03481822v1
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Screening for pancreatic lipase natural modulators by capillary electrophoresis hyphenated to spectrophotometric and conductometric dual detection

Ghassan Al Hamoui Dit Banni , Rouba Nasreddine , Syntia Fayad , Phu Cao-Ngoc , Jean-Christophe Rossi et al.

Analyst, 2021, 146 (4), pp.1386-1401. ⟨10.1039/d0an02234a⟩

Article dans une revue hal-03835824v1

Investigation of lipase-ligand interactions in porcine pancreatic extracts by microscale thermophoresis

Ghassan Al Hamoui Dit Banni , Rouba Nasreddine , Syntia Fayad , Cyril Colas , Axel Marchal et al.

Analytical and Bioanalytical Chemistry, 2021, 413 (14), pp.3667-3681. ⟨10.1007/s00216-021-03314-7⟩

Article dans une revue hal-03307692v1
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Kinetic theory of hyaluronan cleavage by bovine testicular hyaluronidase in standard and crowded environments

Reine Nehmé , Rouba Nasreddine , Lucija Orlic , Chrystel Lopin-Bon , Josef Hamacek et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, 2021, 1865 (3), pp.129837. ⟨10.1016/j.bbagen.2020.129837⟩

Article dans une revue hal-03481898v1
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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

Frédéric Buron , Nuno Rodrigues , Thibault Saurat , Marie-Aude Hiebel , Stéphane Bourg et al.

Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩

Article dans une revue hal-03348966v1
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Microscale thermophoresis for studying protein-small molecule affinity: Application to hyaluronidase

Rouba Nasreddine , Reine Nehmé

Microchemical Journal, 2021, 170, pp.106763. ⟨10.1016/j.microc.2021.106763⟩

Article dans une revue hal-04758194v1
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Water-Based Extraction of Bioactive Principles from Blackcurrant Leaves and Chrysanthellum americanum: A Comparative Study

Phu Cao-Ngoc , Laurent Leclercq , Jean-Christophe Rossi , Jasmine Hertzog , Anne-Sylvie Fabiano-Tixier et al.

Foods, 2020, 9 (10), pp.1478. ⟨10.3390/foods9101478⟩

Article dans une revue hal-03019649v1
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Polyethylene glycol crowding effect on hyaluronidase activity monitored by capillary electrophoresis

Rouba Nasreddine , Lucija Orlic , Ghassan Al Hamoui Dit Banni , Syntia Fayad , Axel Marchal et al.

Analytical and Bioanalytical Chemistry, 2020, 412 (17), pp.4195-4207. ⟨10.1007/s00216-020-02659-9⟩

Article dans une revue hal-02939523v1
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Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation

Nicolas Drouin , Marlien van Mever , Wei Zhang , Elena Tobolkina , Sabrina Ferre et al.

Analytical Chemistry, 2020, 92 (20), pp.14103-14112. ⟨10.1021/acs.analchem.0c03129⟩

Article dans une revue hal-04303264v1
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Monitoring of successive phosphorylations of thymidine using free and immobilized human nucleoside/nucleotide kinases by Flow Injection Analysis with High-Resolution Mass Spectrometry

Justine Ferey , David da Silva , Cyril Colas , Reine Nehmé , Pierre Lafite et al.

Analytica Chimica Acta, 2019, 1049, pp.115-122. ⟨10.1016/j.aca.2018.10.032⟩

Article dans une revue hal-02090335v1
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Capillary electrophoresis with dual detection UV/C4D for monitoring myrosinase-mediated hydrolysis of thiol glucosinolate designed for gold nanoparticle conjugation

Bérengère Claude , Giuliano Cutolo , Amal Farhat , Irina Zarafu , Petre Ionita et al.

Analytica Chimica Acta, 2019, 1085, pp.117 - 125. ⟨10.1016/j.aca.2019.07.043⟩

Article dans une revue hal-03487875v1

Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis

Jean Wilfried Fredy , Giuliano Cutolo , Benjamin Poret , Reine Nehmé , Marie Hubert-Roux et al.

Bioconjugate Chemistry, 2019, 30 (5), pp.1385-1394. ⟨10.1021/acs.bioconjchem.9b00153⟩

Article dans une revue hal-04758207v1
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Effect of modified di- and trisaccharides on hyaluronidase activity assessed by capillary electrophoresis-based enzymatic assay

Syntia Fayad , Benjamin Ayela , Coralie Chat , Philippe Morin , Chrystel Lopin-Bon et al.

Carbohydrate Research, 2019, 475, pp.56 - 64. ⟨10.1016/j.carres.2019.02.006⟩

Article dans une revue hal-03486681v1
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Use of chromatographic and electrophoretic tools for assaying elastase, collagenase, hyaluronidase, and tyrosinase activity

Syntia Fayad , Philippe Morin , Reine Nehmé

Journal of Chromatography A, 2017, 1529, pp.1-28. ⟨10.1016/j.chroma.2017.11.003⟩

Article dans une revue hal-04645321v1
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Macroalga Padina pavonica water extracts obtained by pressurized liquid extraction and microwave-assisted extraction inhibit hyaluronidase activity as shown by capillary electrophoresis

Syntia Fayad , Reine Nehmé , Mona Tannoury , Eric Lesellier , Chantal Pichon et al.

Journal of Chromatography A, 2017, 1497, pp.19-27. ⟨10.1016/j.chroma.2017.03.033⟩

Article dans une revue istex hal-01618229v1
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Preliminary recovery study of a commercial molecularly imprinted polymer for the extraction of glyphosate and AMPA in different environmental waters using MS

Bérengère Claude , Catherine Berho , Sami Bayoudh , Laurence Amalric , Emeline Coisy et al.

Environmental Science and Pollution Research, 2017, 24 (13), pp.12293-12300. ⟨10.1007/s11356-017-8844-5⟩

Article dans une revue hal-01849658v1
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Microalgae amino acid extraction and analysis at nanomolar level using electroporation and capillary electrophoresis with laser-induced fluorescence detection

Reine Nehmé , Carla Atieh , Syntia Fayad , Bérengère Claude , Agnès Chartier et al.

Journal of Separation Science, 2017, 40 (2), pp.558-566. ⟨10.1002/jssc.201601005⟩

Article dans une revue hal-01618682v1

Hyaluronidase reaction kinetics evaluated by capillary electrophoresis with UV and high-resolution mass spectrometry (HRMS) detection

Syntia Fayad , Reine Nehmé , Monika Langmajerová , Benjamin Ayela , Cyril Colas et al.

Analytica Chimica Acta, 2017, 951, pp.140-150. ⟨10.1016/j.aca.2016.11.036⟩

Article dans une revue hal-04270197v1

Human neutrophil elastase inhibition studied by capillary electrophoresis with laser induced fluorescence detection and microscale thermophoresis

Fayad Syntia , Reine Nehmé , Bérengère Claude , Philippe Morin

Journal of Chromatography A, 2016, 1431, pp.215-223. ⟨10.1016/j.chroma.2015.12.079⟩

Article dans une revue hal-04758246v1

New methods based on capillary electrophoresis for in vitro evaluation of protein tau phosphorylation by glycogen synthase kinase 3-β

Hala Nehmé , Sandrine Chantepie , Justine Defert , Philippe Morin , Dulce Papy-Garcia et al.

Analytical and Bioanalytical Chemistry, 2015, 407 (10), pp.2821-2828. ⟨10.1007/s00216-015-8495-7⟩

Article dans une revue hal-04758253v1

Advances in capillary electrophoresis for miniaturizing assays on kinase enzymes for drug discovery

Reine Nehmé , Philippe Morin

Electrophoresis, 2015, 36 (21-22), pp.2768-2797. ⟨10.1002/elps.201500239⟩

Article dans une revue istex hal-04758248v1

Assaying human neutrophil elastase activity by capillary zone electrophoresis combined with laser-induced fluorescence

Syntia Fayad , Reine Nehmé , Pierre Lafite , Philippe Morin

Journal of Chromatography A, 2015, 1419, pp.116-124. ⟨10.1016/j.chroma.2015.09.084⟩

Article dans une revue istex hal-03478319v1
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Coated capillaries with highly charged polyelectrolytes and carbonnanotubes co-aggregated with sodium dodecyl sulphate for theanalysis of sulfonylureas by capillary electrophoresis

Racha El Debs , Bérengère Claude , Anne Togola , Solène Motteau , Reine Nehmé et al.

Journal of Chromatography A, 2014, 1367, pp.161-166. ⟨10.1016/j.chroma.2014.09.047⟩

Article dans une revue istex hal-01086599v1

Contactless conductivity detection for screening myrosinase substrates by capillary electrophoresis

Reine Nehmé , Hala Nehmé , Grégory Roux , Deimante Cerniauskaite , Philippe Morin et al.

Analytica Chimica Acta, 2014, 807, pp.153-158. ⟨10.1016/j.aca.2013.11.012⟩

Article dans une revue hal-04758270v1
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New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway

Reine Nehmé , Hala Nehmé , Thibault Saurat , Marie-Ludivine De-Tauzia , Frédéric Buron et al.

Analytical and Bioanalytical Chemistry, 2014, 406 (15), pp.3743-3754. ⟨10.1007/s00216-014-7790-z⟩

Article dans une revue hal-01180770v1

Electrophoretically mediated microanalysis for in-capillaryelectrical cell lysis and fast enzyme quantification by capillary electrophoresis

Hala Nehmé , Reine Nehmé , Pierre Lafite , Eric Duverger , Sylvain Routier et al.

Analytical and Bioanalytical Chemistry, 2013, 405 (28), pp.9159-9167. ⟨10.1007/s00216-013-7332-0⟩

Article dans une revue istex hal-03478329v1

Capillary electrophoresis as a novel technique for screening natural flavonoids as kinase inhibitors

Reine Nehmé , Hala Nehmé , Grégory Roux , Emilie Destandau , Bérengère Claude et al.

Journal of Chromatography A, 2013, 1318, pp.257-264. ⟨10.1016/j.chroma.2013.10.024⟩

Article dans une revue istex hal-04758300v1

Human protein kinase inhibitor screening by capillary electrophoresis using transverse diffusion of laminar flow profiles for reactant mixing

Hala Nehmé , Reine Nehmé , Pierre Lafite , Sylvain Routier , Philippe Morin

Journal of Chromatography A, 2013, 1314, pp.298-305. ⟨10.1016/j.chroma.2013.08.046⟩

Article dans une revue istex hal-04440284v1

In-capillary reactant mixing for monitoring glycerol kinase kinetics by CE

Hala Nehmé , Reine Nehmé , Pierre Lafite , Sylvain Routier , Philippe Morin

Journal of Separation Science, 2013, 36 (13), pp.2151-2157. ⟨10.1002/jssc.201300063⟩

Article dans une revue istex hal-03478330v1

New development in in-capillary electrophoresis techniques for kinetic and inhibition study of enzymes

Hala Nehme , Reine Nehme , Pierre Lafite , Sylvain Routier , Philippe Morin

Analytica Chimica Acta, 2012, 722, pp.127-135. ⟨10.1016/j.aca.2012.02.003⟩

Article dans une revue istex hal-04440273v1

Analysis of urinary neurotransmitters by capillary electrophoresis: Sensitivity enhancement using field-amplified sample injection and molecular imprinted polymer solid phase extraction

Bérengère Claude , Reine Nehmé , Philippe Morin

Analytica Chimica Acta, 2011, 699 (2), pp.242-248. ⟨10.1016/j.aca.2011.05.014⟩

Article dans une revue istex hal-04758320v1

Stability of capillaries coated with highly charged polyelectrolyte monolayers and multilayers under various analytical conditions - Applications to protein analysis

Reine Nehmé , Catherine Perrin , Hervé Cottet , Marie-Dominique Blanchin , Huguette Fabre

Journal of Chromatography A, 2011, 1218 (22), pp.3537-3544. ⟨10.1016/j.chroma.2011.03.040⟩

Article dans une revue istex hal-00772504v1

Capillary electrophoresis procedure for the simultaneous analysis and stoichiometry determination of a drug and its counter-ion by using dual-opposite end injection and contactless conductivity detection: Application to labetalol hydrochloride

Reine Nehmé , Adrien Lascaux , Raphaël Delépée , Bérengère Claude , Philippe Morin

Analytica Chimica Acta, 2010, 663 (2), pp.190-197. ⟨10.1016/j.aca.2010.01.032⟩

Article dans une revue istex hal-03593446v1

Capillary electrophoresis procedure for the simultaneous analysis and stoichiometry determination of a drug and its counter-ion by using dual-opposite end injection and contactless conductivity detection: Application to labetalol hydrochloride

Reine Nehmé , Adrien Lascaux , Raphaël Delépée , Bérengère Claude , Philippe Morin

Analytica Chimica Acta, 2010, 663 (2), pp.190-197. ⟨10.1016/j.aca.2010.01.032⟩

Article dans une revue istex hal-04758324v1

Use of coated capillaries for the electrophoretic separation of stereoisomers of a growth hormone secretagogue

Jean-Alain Fehrentz , Reine Nehmé , Catherine Perrin , Vincent Guerlavais , Hervé Cottet et al.

Electrophoresis, 2009, 30 (21), pp.3772-3779. ⟨10.1002/elps.200900093⟩

Article dans une revue istex hal-00485769v1

Influence of polyelectrolyte capillary coating conditions on protein analysis in CE

Reine Nehmé , Catherine Perrin , Hervé Cottet , Marie‐dominique Blanchin , Huguette Fabre

Electrophoresis, 2009, 30 (11), pp.1888-1898. ⟨10.1002/elps.200800688⟩

Article dans une revue istex hal-04758329v1

Influence of polyelectrolyte coating conditions on capillary coating stability and separation efficiency in capillary electrophoresis

Reine Nehmé , Catherine Perrin , Hervé Cottet , Marie Blanchin , Huguette Fabre

Electrophoresis, 2008, 29 (14), pp.3013-3023. ⟨10.1002/elps.200700886⟩

Article dans une revue istex hal-04758333v1