Rabah Gahoual

Enseignant-chercheur en chimie analytique Université Paris Cité, Faculté de Pharmacie
35
Documents
Affiliation actuelle
  • Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1267))
Identifiants chercheurs

Domaines de recherche

Chimie analytique

Compétences

Chimie analytique Spectrométrie de masse électrophorèse capillaire anticorps monoclonaux glycosylation échantillons biologiques

Publications

Publications

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Characterization and quantification of therapeutic monoclonal antibodies, anti-drug antibodies and their interactions for clinical applications

Lola Alez-Martin , Emilie Hirschler , Pascal Houzé , Noëlle Potier , Nathalie Mignet et al.

Trends in Analytical Chemistry, 2025, 192, pp.118385. ⟨10.1016/j.trac.2025.118385⟩

Article dans une revue hal-05390034v1
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Therapeutic monoclonal antibody - Anti-drug antibody affinity constant determination using capillary electrophoresis -tandem mass spectrometry

Tessa Reinert , Pascal Houzé , Nathalie Mignet , Aynur Naghizade , Lola Alez-Martin et al.

Analytical Chemistry, 2024, 96 (49), pp.19286-19293. ⟨10.1021/acs.analchem.4c02932⟩

Article dans une revue hal-05237144v1
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Post-translational modifications comparative identification and kinetic study of infliximab innovator and biosimilars in serum using capillary electrophoresis-tandem mass spectrometry

Tessa Reinert , Pascal Houzé , Nathalie Mignet , Yannis-Nicolas Francois , Rabah Gahoual

Journal of Pharmaceutical and Biomedical Analysis, 2023, 234, pp.115541. ⟨10.1016/j.jpba.2023.115541⟩

Article dans une revue hal-04599782v1
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Simultaneous quantification and structural characterization of monoclonal antibodies after administration using capillary zone electrophoresis-tandem mass spectrometry

Tessa Reinert , Rabah Gahoual , Nathalie Mignet , Alexandre Kulus , Matthieu Allez et al.

Journal of Pharmaceutical and Biomedical Analysis, 2023, 233, pp.115446. ⟨10.1016/j.jpba.2023.115446⟩

Article dans une revue hal-04599685v1
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Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy

Panpan Ma , Johanne Seguin , Nhu Ky Ly , Luis Castillo-Henríquez , Eva Plansart et al.

International Journal of Pharmaceutics: X, 2022, 4, pp.100138. ⟨10.1016/j.ijpx.2022.100138⟩

Article dans une revue hal-04090295v1
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CEToolbox: Specialized calculator for capillary electrophoresis users as an android application

Yannis François , Michael Biacchi , Rabah Gahoual , Aurélien Vezin , Jerôme Pansanel

Electrophoresis, 2021, 42 (14-15), pp.1431-1435. ⟨10.1002/elps.202100036⟩

Article dans une revue hal-03408175v1

Comprehensive and quantitative stability study of ascorbic acid using capillary zone electrophoresis with ultraviolet detection and high-resolution tandem mass spectrometry

Pauline Legrand , Rabah Gahoual , Raphael Benattar , Balthazar Toussaint , Caroline Roques et al.

Journal of Separation Science, 2020, 43 (14), pp.2925-2935. ⟨10.1002/jssc.202000389⟩

Article dans une revue hal-03289975v1
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Kinetic and structural characterization of therapeutic albumin chemical functionalization using complementary mass spectrometry techniques

Rabah Gahoual , Gérard Bolbach , Ikram Ould-Melha , Gilles Clodic , Yannis Francois et al.

Journal of Pharmaceutical and Biomedical Analysis, 2020, 185, pp.113242. ⟨10.1016/j.jpba.2020.113242⟩

Article dans une revue hal-03022806v1
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Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future

Alain Beck , Valentina D’atri , Anthony Ehkirch , Szabolcs Fekete , Oscar Hernandez-Alba et al.

Expert Review of Proteomics, 2019, 16 (4), pp.337-362. ⟨10.1080/14789450.2019.1578215⟩

Article dans une revue hal-02272143v1
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Conception of nanosized hybrid liposome/poloxamer particles to thicken the interior core of liposomes and delay hydrophilic drug delivery

Shayan Ahmed , Yohann Corvis , Rabah Gahoual , Arlen Euan , Rene Lai-Kuen et al.

International Journal of Pharmaceutics, 2019, 567, ⟨10.1016/j.ijpharm.2019.118488⟩

Article dans une revue hal-03290600v1
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Is Capillary Electrophoresis a New Tool to Monitor Acute Lithium Poisoning in Human?

Tsandni Jamal , Carole Hennequin , Rabah Gahoual , Annie Leyris , Jean-Louis Beaudeux et al.

Journal of Analytical Toxicology, 2019, 43 (7), pp.571-578. ⟨10.1093/jat/bkz013⟩

Article dans une revue hal-03175919v1
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Site-specific N-and O-glycosylation analysis of atacicept

Kathrin Stavenhagen , Rabah Gahoual , Elena Dominguez Vega , Angelo Palmese , Agnes L Hipgrave Ederveen et al.

mAbs, 2019, 11 (6), pp.1053-1063. ⟨10.1080/19420862.2019.1630218⟩

Article dans une revue hal-03175711v1
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Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics

Hugo Salmon , Rabah Gahoual , Pascal Houzé , Tayssir Ibrahim , Michel Bessodes et al.

Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 18, pp.21-30. ⟨10.1016/j.nano.2019.02.011⟩

Article dans une revue hal-02123126v1
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Insights from capillary electrophoresis approaches for characterization of monoclonal antibodies and antibody drug conjugates in the period 2016–2018

Antony Lechner , Jeremie Giorgetti , Rabah Gahoual , Alain Beck , Emmanuelle Leize-Wagner et al.

Journal of Chromatography B Biomedical Sciences and Applications, 2019, 1122-1123, pp.1-17. ⟨10.1016/j.jchromb.2019.05.014⟩

Article dans une revue hal-02399570v1
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Disorder-to-Order Markers of a Cyclic Hexapeptide Inspired from the Binding Site of Fertilin β Involved in Fertilization Process

Belén Henández , Pauline Legrand , Sophie Dufay , Rabah Gahoual , Santiago Sanchez-Cor- Tes et al. Article dans une revue hal-03183727v1
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Affinity profiling of monoclonal antibody and antibodydrug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Dina Lakayan , Rob Haselberg , Rabah Gahoual , Govert W Somsen , Jeroen Kool

Analytical and Bioanalytical Chemistry, 2018, 410 (30), pp.7837-7848. ⟨10.1007/s00216-018-1414-y⟩

Article dans une revue hal-03039563v1
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Revealing the potential of capillary electrophoresis/mass spectrometry: the tipping point

Rabah Gahoual , Emmanuelle Leize‐wagner , Pascal Houzé , Yannis‐nicolas François

Rapid Communications in Mass Spectrometry, 2018, 1st European Mass Spectrometry Conference (EMSC), 33 (S1), pp.11 - 19. ⟨10.1002/rcm.8238⟩

Article dans une revue hal-03892201v2
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Advanced Antibody-Drug Conjugate Structural Characterization by Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry Using Complementary Approaches

Nassur Said , Jérémie Giorgetti , Lauriane Kuhn , Alain Beck , Emmanuelle Leize-Wagner et al.

LCGC Current Trends in Mass Spectroscopy, 2017, 15 (1), pp.15-21

Article dans une revue hal-03206734v1
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Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry

Rabah Gahoual , Anna-Katharina Heidenreich , Govert W Somsen , Patrick Bulau , Dietmar Reusch et al.

Analytical Chemistry, 2017, 89 (10), pp.5404-5412. ⟨10.1021/acs.analchem.7b00211⟩

Article dans une revue hal-03206846v1
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Characterization of cetuximab Fc/2 dimers by off-line CZE-MS

Yannis-Nicolas François , Michael Biacchi , Nassur Said , Charly Renard , Alain Beck et al.

Analytica Chimica Acta, 2016, 908, pp.168-176. ⟨10.1016/j.aca.2015.12.033⟩

Article dans une revue hal-01981314v1
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Independent highly sensitive characterization of asparagine deamidation and aspartic acid isomerization by sheathless CZE-ESI-MS/MS

Rabah Gahoual , Alain Beck , Yannis-Nicolas François , Emmanuelle Leize-Wagner

Journal of Mass Spectrometry, 2016, 51 (2), pp.150-158. ⟨10.1002/jms.3735⟩

Article dans une revue hal-01981310v1
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Cutting-edge capillary electrophoresis characterization of monoclonal antibodies and related products

Rabah Gahoual , Alain Beck , Emmanuelle Leize-Wagner , Yannis-Nicolas François

Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2016, 1032, pp.61-78. ⟨10.1016/j.jchromb.2016.05.028⟩

Article dans une revue hal-01981308v1
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Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis – Tandem mass spectrometry as nanoESI infusion platform and separation method

Nassur Said , Rabah Gahoual , Lauriane Kuhn , Alain Beck , Yannis-Nicolas Francois et al.

Analytica Chimica Acta, 2016, 918, pp.50-59. ⟨10.1016/j.aca.2016.03.006⟩

Article dans une revue hal-01981303v1
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Improvement of Mitochondria Extract from Saccharomyces cerevisiae Characterization in Shotgun Proteomics Using Sheathless Capillary Electrophoresis Coupled to Tandem Mass Spectrometry

Marianne Ibrahim , Rabah Gahoual , Ludovic Enkler , Hubert Becker , Johana Chicher et al.

Journal of Chromatographic Science, 2016, 54 (4), pp.653-663. ⟨10.1093/chromsci/bmw005⟩

Article dans une revue hal-02918628v1

Priming cells for their final destination: microenvironment controlled cell culture by a modular ECM-mimicking feeder film

Julien Barthes , Nihal E. Vrana , Hayriye Oezcelik , Rabah Gahoual , Yannis N. Francois et al.

Biomaterials Science, 2015, 3 (9), pp.1302-1311. ⟨10.1039/c5bm00172b⟩

Article dans une revue hal-01505605v1
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Glycoform Separation and Characterization of Cetuximab Variants by Middle-up Off-Line Capillary Zone Electrophoresis-UV/Electrospray Ionization-MS

Michael Biacchi , Rabah Gahoual , Nassur Said , Alain Beck , Emmanuelle Leize-Wagner et al.

Analytical Chemistry, 2015, 87 (12), pp.6240-6250. ⟨10.1021/acs.analchem.5b00928⟩

Article dans une revue hal-01981309v1
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Novel sheathless CE-MS interface as an original and powerful infusion platform for nanoESI study: from intact proteins to high molecular mass noncovalent complexes.

Rabah Gahoual , Jean-Marc Busnel , Philippe Wolff , Yannis François , Emmanuelle Leize-Wagner

Analytical and Bioanalytical Chemistry, 2014, 406 (4), pp.1029-1038. ⟨10.1007/s00216-013-7226-1⟩

Article dans une revue hal-02991315v1
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Full Antibody Primary Structure and Microvariant Characterization in a Single Injection Using Transient Isotachophoresis and Sheathless Capillary Electrophoresis–Tandem Mass Spectrometry

Rabah Gahoual , Jean-Marc Busnel , Alain Beck , Yannis-Nicolas François , Emmanuelle Leize-Wagner

Analytical Chemistry, 2014, 86 (18), pp.9074-9081. ⟨10.1021/ac502378e⟩

Article dans une revue hal-01981311v1
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Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry

Rabah Gahoual , Michaël Biacchi , Johana Chicher , Lauriane Kuhn , Philippe Hammann et al.

mAbs, 2014, 6 (6), pp.1464-1473. ⟨10.4161/mabs.36305⟩

Article dans une revue hal-01981312v1
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Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry

Rabah Gahoual , Alicia Burr , Jean-Marc Busnel , Lauriane Kuhn , Philippe Hamman et al.

mAbs, 2013, 5 (3), pp.479-490. ⟨10.4161/mabs.23995⟩

Article dans une revue hal-01984367v1