Sébastien BROT

Research Engineer at University of Poitiers
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Publications

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Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease

Bérangère Ballion , Marie-Laure Bonnet , Sébastien Brot , Afsaneh Gaillard

Current Stem Cell Research & Therapy, 2025, 16 (1), pp.232. ⟨10.1186/s13287-025-04344-z⟩

Article dans une revue hal-05063750v1

Host-to-graft Propagation of α-synuclein in a Mouse Model of Parkinson’s Disease: Intranigral Versus Intrastriatal Transplantation

Maëlig Patrigeon , Sébastien Brot , Marie-Laure Bonnet , Laure Belnoue , Afsaneh Gaillard

Transplantation, 2023, 107 (8), p. 201-212. ⟨10.1097/TP.0000000000004565⟩

Article dans une revue hal-04132835v1
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Deciphering Brain Metastasis Stem Cell Properties From Colorectal Cancer Highlights Specific Stemness Signature and Shared Molecular Features

Amandine Desette , Pierre-Olivier Guichet , Sheik Emambux , Konstantin Masliantsev , Ulrich Cortes et al.

Cellular and Molecular Gastroenterology and Hepatology, 2023, 16 (5), pp.757-782. ⟨10.1016/j.jcmgh.2023.07.008⟩

Article dans une revue hal-04302791v1
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Long-Term Evaluation of Intranigral Transplantation of Human iPSC-Derived Dopamine Neurons in a Parkinson’s Disease Mouse Model

Sébastien Brot , Nabila Pyrenina Thamrin , Marie-Laure Bonnet , Maureen Francheteau , Maëlig Patrigeon et al.

Cells, 2022, 11 (10), pp.1596. ⟨10.3390/cells11101596⟩

Article dans une revue hal-03682097v1

Beneficial Effects of Hyaluronan-Based Hydrogel Implantation after Cortical Traumatic Injury

Anaïs Lainé , Sébastien Brot , Afsaneh Gaillard

Cells, 2022, 11 (23), pp.3831. ⟨10.3390/cells11233831⟩

Article dans une revue hal-04132825v1
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Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation: Relevance for Parkinson’s Disease

Marine Droguerre , Sébastien Brot , Clément Vitrac , Marianne Benoit-Marand , Laure Belnoue et al.

Cells, 2022, 11 (7), ⟨10.3390/cells11071191⟩

Article dans une revue hal-03637153v1

Neuroprotective effects of neuropeptide Y against neurodegenerative disease

Stéphanie Pain , Sébastien Brot , Afsaneh Gaillard

Current Neuropharmacology, 2021, 19, ⟨10.2174/1570159X19666210906120302⟩

Article dans une revue hal-03361423v1

Characterization of Inflammation in Delayed Cortical Transplantation

Nissrine Ballout , Tristan Rochelle , Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau et al.

Frontiers in Molecular Neuroscience, 2019, 12, ⟨10.3389/fnmol.2019.00160⟩

Article dans une revue hal-02498268v1
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A Delay between Motor Cortex Lesions and Neuronal Transplantation Enhances Graft Integration and Improves Repair and Recovery

Sophie Péron , Marine Droguerre , Franck Debarbieux , Nissrine Ballout , Marianne Benoit-Marand et al.

Journal of Neuroscience, 2017, 37 (7), pp.1820-1834. ⟨10.1523/JNEUROSCI.2936-16.2017⟩

Article dans une revue hal-02500429v1

Collapsin response-mediator protein 5 (CRMP5) phosphorylation at threonine 516 regulates neurite outgrowth inhibition

Sébastien Brot , Hinda Smaoune , Mina Youssef-Issa , Céline Malleval , Claire Benetollo et al.

European Journal of Neuroscience, 2014, 40 (7), pp.3010-3020. ⟨10.1111/ejn.12674⟩

Article dans une revue istex hal-02511291v1

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA

Dominique Bétemps , Jérémy Verchère , Sébastien Brot , Eric Morignat , Luc Bousset et al.

Acta Neuropathologica Communications, 2013, 2, pp.29. ⟨10.1186/2051-5960-2-29⟩

Article dans une revue hal-01183383v1

Collapsin Response Mediator Protein 5 (CRMP5) Induces Mitophagy Thereby Regulating Mitochondrion Numbers in Dendrites.

Sébastien Brot , Carole Auger , Rabia Bentata , Véronique Rogemond , Stéphane Ménigoz et al.

Journal of Biological Chemistry, 2013, 289, pp.2261-2276. ⟨10.1074/jbc.M113.490862⟩

Article dans une revue hal-00917349v1

Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation

Sébastien Brot , Céline Malleval , Claire Benetollo , Carole Auger , David Meyronet et al.

Experimental Cell Research, 2013, 319 (5), pp.588-599. ⟨10.1016/j.yexcr.2012.12.011⟩

Article dans une revue istex hal-02511307v1
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CRMP5 Interacts with Tubulin to Inhibit Neurite Outgrowth, Thereby Modulating the Function of CRMP2

Sébastien Brot , Véronique Rogemond , Valérie Perrot , Naura Chounlamountri , Carole Auger et al.

Journal of Neuroscience, 2010, 30 (32), pp.10639-10654. ⟨10.1523/JNEUROSCI.0059-10.2010⟩

Article dans une revue hal-02351827v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot

PHysiopathology Of Parkinson’s disEase » (HOPE), Jan 2020, Paris, France

Communication dans un congrès hal-02511362v1

La reprogrammation d’hiPSC par ARNm, une nouvelle approche pour la transplantation de neurones dopaminergiques

Sébastien Brot

Journée scientifique SFR FED 4226 Neuroimagerie Fonctionnelle, Jun 2017, Poitiers, France

Communication dans un congrès hal-02511347v1
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COMBINATION OF EXERCICE ANS STEM CELL-BASED STRATEGIES TO IMPROVE CORTICAL REPAIR

Valentin Fernandez , Annousha Govindan , Marie-Laure Bonnet , Eric Balado , Sébastien Brot et al.

25th biennial meeting of the international society for developmental neuroscience, Sep 2024, Montpellier, France

Poster de conférence hal-05517125v1

Functional integration of grafted hiPSC derived dopamine neurons in a mouse model of Parkinson's disease

Bérangère Ballion , Marie-Laure Bonnet , Sébastien Brot , Afsaneh Gaillard

NeuroFrance 2023, May 2023, Lyon, France

Poster de conférence hal-05093772v1

Transplantation of iPSC-derived dopamine neurons in alpha-synuclein overexpression mouse model

Laure Belnoue , Maëlig Patrigeon , Marie-Laure Bonnet , Sébastien Brot , Afsaneh Gaillard

NeuroFrance 2023, May 2023, Lyon, France

Poster de conférence hal-05008254v1

Functional integration of intranigral grafted hiPSC derived dopamine neurons in a mouse model of Parkinson disease

Bérangère Ballion , Sébastien Brot , Laure Belnoue , Afsaneh Gaillard

FENS Forum 2022, Jul 2022, Paris, France.

Poster de conférence hal-04517426v1

Host to graft propagation of alpha-synuclein in Parkinson’s disease: intra-nigral versus intra-striatal transplantation

Maëlig Patrigeon , Sébastien Brot , Marie-Laure Bonnet , Laure Belnoue , Afsaneh Gaillard

13th FENS Forum of Neuroscience, Jul 2022, Paris, France

Poster de conférence hal-05008798v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Bérangère Ballion , Maëlig Patrigeon , Maureen Francheteau et al.

13th FENS Forum of Neuroscience, Jul 2022, Paris, France

Poster de conférence hal-05008791v1

Host to graft propagation of α-synuclein in Parkinson’s disease: intra-nigral versus intra-striatal transplantation.

Maëlig Patrigeon , Sébastien Brot , Marie-Laure Bonnet , Laure Belnoue , Afsaneh Gaillard

NeuroFrance 2021, May 2021, Strasbourg, France

Poster de conférence hal-03221475v1

The potential of motor cortical neurons derived hiPSC transplantation for brain repair following traumatic brain injury

Laure Belnoue , Hammam I. El Hajj , Marie-Laure Bonnet , Sébastien Brot , Afsaneh Gaillard

NeuroFrance 2021, May 2021, Strasbourg, France

Poster de conférence hal-03221118v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Bérangère Ballion , Maëlig Patrigeon , Maureen Francheteau et al.

31st Annual meeting of the Network for European CNS Transplantation and Restoration (NECTAR), Nov 2021, Edinburgh, France.

Poster de conférence hal-03637185v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Maëlig Patrigeon , Maureen Francheteau , Laure Belnoue et al.

NeuroFrance 2021, May 2021, Strasbourg, France

Poster de conférence hal-03221124v1
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Biomaterials to enhance the integration of grafted human iPSC-derived motor cortical neurons in a mice model of traumatic injury

Oriane Rabesandratana , Anaïs Lainé , Marie-Laure Bonnet , Laure Belnoue , Sébastien Brot et al.

FSSCR annual meeting 2021, Nov 2021, Montpellier, France

Poster de conférence hal-03489108v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Bérangère Ballion , Maëlig Patrigeon , Maureen Francheteau et al.

31st Annual meeting of the Network for European CNS Transplantation and Restoration (NECTAR), Nov 2021, Edinburg, United Kingdom

Poster de conférence hal-05008766v1

Modelling Parkinson´s disease with patient induced pluripotent stem cells

Nabila Pyrenina Thamrin , Marie-Laure Bonnet , Maëlig Patrigeon , Laure Belnoue , Jean Christophe C Corvol et al.

NeuroFrance 2021, May 2021, Strasbourg, France

Poster de conférence hal-03221486v1

Functional integration of grafted hiPSC derived dopamine neurons in a murine model of Parkinson's disease

Bérangère Ballion , Laure Belnoue , Sébastien Brot , Afsaneh Gaillard

NeuroFrance 2021, May 2021, Strasbourg, France

Poster de conférence hal-03405614v1

Therapeutic effects of hyaluronan-based hydrogel after cortical traumatic injury

Anaïs Lainé , Sébastien Brot , Oriane Rabesandratana , Afsaneh Gaillard

NeuroFrance 2021, May 2021, Strasbourg, France

Poster de conférence hal-03221468v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau , Laure Belnoue , Afsaneh Gaillard

PHysiopathology Of Parkinson’s disEase » (HOPE), Jan 2020, Paris, France

Poster de conférence hal-02511393v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau , Afsaneh Gaillard

LE STUDIUM CONFERENCE : Induced Pluripotent Stem Cells (iPSCs): From Disease Models to Mini-Organs, Jan 2019, Tours, France

Poster de conférence hal-02512709v1

Absence of interleukin 33 impaired axonal outgrowth of grafted cortical neurons.

Anaïs Lainé , Nissrine Ballout , Marie Droguerre , Sébastien Brot , Maureen Francheteau et al.

NeuroFrance, the international conference of the french society of Neuroscience, May 2019, Marseille, France

Poster de conférence hal-02547007v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau , Afsaneh Gaillard

FSSCR 3rd Annual Meeting, Nov 2019, Lyon, France

Poster de conférence hal-02512692v1

The potential of motor cortical neurons derived hiPSC transplantation for brain repair following traumatic brain injury

Hammam L El Hajj , Laure Belnoue , Marie-Laure Bonnet , Sébastien Brot , Afsaneh Gaillard

Neurofrance, Jun 2019, Marseille, France

Poster de conférence hal-02516060v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau , Afsaneh Gaillard

From 3D culture to organoïds - AVIESAN, Dec 2019, Paris, France

Poster de conférence hal-02512008v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau , Afsaneh Gaillard

11th FENS Forum of Neuroscience, Jul 2018, Berlin, Germany

Poster de conférence hal-02512713v1

Differentiation of human iPSC into neurons of motor cortex and grafting into injured motor cortex of adult mice

Hammam L El Hajj , Sébastien Brot , Marie-Laure Bonnet , Afsaneh Gaillard

11th FENS forum of Neurosciences, Jul 2018, Berlin, Germany

Poster de conférence hal-02516097v1

Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease

Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau , Afsaneh Gaillard

Symposium "(Re)Constructing the nervous system: stem cells and beyond" Institut fer à Moulin, Sep 2017, Paris, France

Poster de conférence hal-02516028v1

Dopamine neurons derived from human induced pluripotent stem cell reprogrammed by mRNA

Sébastien Brot , Marie-Laure Bonnet , Maureen Francheteau , Afsaneh Gaillard

Neurofrane, May 2017, Bordeaux, France

Poster de conférence hal-02516038v1

Beneficial effects of inflammation in delayed cortical transplantation

Nissrine Ballout , Tristan Rochelle , Sébastien Brot , Maureen Francheteau , Jean-Marc Gombert et al.

Neurofrance, May 2017, Bordeaux, France

Poster de conférence hal-02517467v1

Molecular and cellular alterations underlying motor disorders in autism spectrum disorders mouse models

Obélia Haida , Tareq Al Sagheer , Anais Balbous , Sébastien Brot , Maureen Francheteau et al.

Séminaire thématique bio-santé ED 524, Mar 2016, Pouligny-Notre-Dame, France

Poster de conférence hal-02556995v1

Production and characterization of dopaminergic neurons derived from mouse embryonic stem cells

Sandie Brisson , Bhaskar Saha , Tristan Rochelle , Sébastien Brot , Marie-Laure Bonnet et al.

Plasticité cérébrale, de la recherche fondamentale à la clinique - 2e Journées Thématiques de la société des neurosciences, May 2016, Tours, France

Poster de conférence hal-02517846v1

Study of Neuroinflammation after cortical lesion and transplantation with or without delay

Nissrine Ballout , Tristan Rochelle , Sébastien Brot , Maureen Francheteau , Jean-Marc Gombert et al.

Plasticité cérébrale, de la recherche fondamentale à la clinique 2e Journées Thématiques de la société des Neurosciences, May 2016, Tours, France

Poster de conférence hal-02517855v1

Production and characterization of dopaminergic neurons derived from mouse embryonic stem cells

Sébastien Brot , Sandie Brisson , Bhaskar Saha , Tristan Rochelle , Marie-Laure Bonnet et al.

3ème Journée Scientifique de la SFR Tours-Poitiers, Jun 2015, Tours, France

Poster de conférence hal-02517803v1

Study of Neuroinflammation after cortical lesion and transplantation with or without delay

Nissrine Ballout , Tristan Rochelle , Sébastien Brot , Maureen Francheteau , Jean-Marc Gombert et al.

12e colloque de la société des Neurosciences, May 2015, Montpellier, France

Poster de conférence hal-02517504v1

Delaying cortical transplantation improves the outcome of the graft

Afsaneh Gaillard , Sophie Péron , Marine Droguerre , Nissrine Ballout , Sébastien Brot et al.

9th FENS Forum of Neuroscience, Jul 2014, Milan, Italy

Poster de conférence hal-02517797v1

Nigrostriatal pathway reconstruction by transplanting embryonic stem cell-derived dopaminergic neurons in Parkinson’s disease

Tristan Rochelle , Sandie Brisson , Sébastien Brot , Marie-Laure Bonnet , Marine Droguerre et al.

2ème Journée Scientifique de la SFR Tours-Poitiers, Jun 2014, Poitiers, France

Poster de conférence hal-02517734v1

Production and characterization of dopaminergic neurons derived from mouse embryonic stem cells

Sandie Brisson , Bhaskar Saha , Tristan Rochelle , Sébastien Brot , Marie-Laure Bonnet et al.

Journée de recherche Tours-Poitiers-Limoges, Jan 2014, Tours, France

Poster de conférence hal-02517712v1

Collapsin Response Mediator Protein 5, a multifunction protein involved in neuronal polarity and mitochondrial machinery

Sébastien Brot , Carole Auger , Véronique Rogemond , Jérome Honnorat , Mahnaz Moradi-Améli

7th FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands

Poster de conférence hal-02518829v1

Differential localization of CRMP5 in cancer cells compared to normal condition

Sébastien Brot , Claire Benetollo , Celine Malleval , Jérome Honnorat

5ème journée scientifique du CLARA "Cancéropôle Lyon Auvergne Rhône-Alpes", Mar 2010, Lyon, France

Poster de conférence hal-02518843v1

Identification of a direct interaction between CRMP5 and tubulin involved in neurite outgrowth inhibition

Sébastien Brot , Véronique Rogemond , Valérie Perrot , Naura Chounlamountri , Carole Auger et al.

9ème Colloque de la société des Neurosciences, May 2009, Bordeaux, France

Poster de conférence hal-02518885v1

Study of CRMP5 properties and its role in the development of cerebral tumors

Sébastien Brot , Celine Malleval , Jérome Honnorat , Mahnaz Moradi-Améli

3ème journée scientifique du CLARA "Cancéropôle Lyon Auvergne Rhône-Alpes", Mar 2008, Lyon, France

Poster de conférence hal-02518895v1