Stephane Savary
- Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA)
- Université Bourgogne Europe (UBE)
Présentation
Stéphane SAVARY CSGA
UMR6265 CNRS, 1324 INRAE, Institut Agro Dijon, Université Bourgogne Europe
Equipe NeuroFeed
9E, boulevard Jeanne d'Arc, 21000 Dijon, France
https://csga.fr/ POSITIONS AND EMPLOYMENT
Since 2012: Professor of Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne
1998-2012 : Associate Professor, Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne
1996-1998 : Assistant Professor, Molecular Biology, University of Tours, Postdoc in the Research Institute of Insect Biology, Genomic relationship between the wasp Cotesia congregata and its symbiotic polydnavirus. EDUCATION AND TRAINING
2004 - Habilitation to Supervise Researches, Univeristy of Bourgogne, “Cloning and characterization of the ABCD2 gene: therapeutic hope for adrenoleukodystrophy”
1996 - PhD. Immunology, University of the Mediterranean Marseille, France, CIML, Identification and characterization of novel ABC transporters in mammals.
1993 - MS Immunology, University of the Mediterranean Marseille, France
1989-1992 - BS,MS Biochemistry, University of the Mediterranean Marseille, France THESIS AND MASTER SUPERVISION
Supervisor of 8 PhD students
Supervisor of 10 Master students
Supervisor of 2 postdoctoral fellows RESEARCH RESPONSABILITIES
2023 : Director of the Lab. BioperoxIL, EA7270 University of Bourgogne
2017-2023: Deputy Director of BioperoxIL
2004-2023: Head of the research group “ABCD transporters and X-ALD”, BioperoxIL PUBLICATIONS
http://www.researcherid.com/rid/C-8137-2011
52 publications since 1994, average citation per article 35, Average iF 5,1 , h-index 23 (Jan 2025) OTHER EXPERIENCES AND PROFESSIONAL MEMBERSHIP SCIENTIFIC SUMMARY
Cloning of novel ABC transporters in mammals
ABCA1 - Tangier Disease, Cholesterol efflux https://omim.org/entry/600046
ABCB7 - Sideroblastic Anemia https://omim.org/entry/300135
ABCG1 - Cholesterol efflux https://omim.org/entry/603076
ABCD2 - Closest homolog of ABCD1, whose defect is associated with X-linked adrenoleukodystrophy https://omim.org/entry/601081 ABCD2, a therapeutic target for X-ALD
Transcriptional regulation of the Abcd2 gene
PPARalpha pathway, fibrates, fatty acids
DHEA, Thyroid hormone and thyromimetics as inducers
Phenyl butyrate and chromatin remodeling
LXR antagonists Structure-function analysis of ABCD2
Substrate specificity
Functional redundancy
Oligomerization Microglia and physiopathogenesis of X-ALD
Establishment of BV2 microglial mutant cell lines using CRISPR-mediated edition of Abcd1, Abcd2, Acox1 genes
Biochemical and functional characterization (lipids, membrane properties, phagocytosis, cytokines, ...)
Co-culture with oligodendrocytes or neurons (link between microglial peroxisomes and neurodegeneration)
Co-culture with T lymphocytes (link between microglial peroxisomes and immune response) Peroxisome, lipid sensing and control of food intake (from Jan 2024)
Domaines de recherche
Publications
Publications
Lessons from impaired peroxisomal function in microglia: implications for neuroinflammation and neuronal healthEMBO Workshop "Celebrating 70 years of peroxisome research", Sep 2025, Sant Feliu De Guixols, Spain |
X-linked AdrenoleukodystrophyMorgan & Claypool Publishers, 2 (1), pp.1-134, 2013, Genetic Basis of Disease, Michael Dean, 9781615045549 |