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Stephane Savary

Professeur des Universités en Biochimie et Biologie Moléculaire
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  • 1096468
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Présentation

**Stéphane SAVARY** CSGA UMR6265 CNRS, 1324 INRAE, Institut Agro Dijon, Université de Bourgogne Equipe 5, Neurobiologie des Comportements Alimentaires 9E, boulevard Jeanne d'Arc, 21000 Dijon, France https://www2.dijon.inrae.fr/csga/ **POSITIONS AND EMPLOYMENT** Since 2012: Professor of Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne 1998-2012 : Associate Professor, Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne 1996-1998 : Assistant Professor, Molecular Biology, University of Tours, Postdoc in the Research Institute of Insect Biology, Genomic relationship between the wasp Cotesia congregata and its symbiotic polydnavirus. **EDUCATION AND TRAINING** 2004 - Habilitation to Supervise Researches, Univeristy of Bourgogne, “Cloning and characterization of the ABCD2 gene: therapeutic hope for adrenoleukodystrophy” 1996 - PhD. Immunology, University of the Mediterranean Marseille, France, CIML, Identification and characterization of novel ABC transporters in mammals. 1993 - MS Immunology, University of the Mediterranean Marseille, France 1989-1992 - BS,MS Biochemistry, University of the Mediterranean Marseille, France **THESIS AND MASTER SUPERVISION** Supervisor of 8 PhD students Supervisor of 10 Master students Supervisor of 2 postdoctoral fellows **RESEARCH RESPONSABILITIES** 2023 : Director of the Lab. BioperoxIL, EA7270 University of Bourgogne 2017-2023: Deputy Director of BioperoxIL 2004-2023: Head of the research group “ABCD transporters and X-ALD”, BioperoxIL **PUBLICATIONS** http://www.researcherid.com/rid/C-8137-2011 49 publications since 1994, average citation per article 30, Average iF 5,2 , h-index 21 (Jan 2024) **OTHER EXPERIENCES AND PROFESSIONAL MEMBERSHIP** - President of the BCP 64/65 University of Bourgogne - Elected to the Administrative Council of the IUT of Dijon 2018-2022 - Member of the concil of the Doctoral School Environment-Health of the University of Bourgogne-Franche-Comté since 2017 (http://www.ecoledoctoralee2s.com/) - Elected to the Comission of human ressources of the IUT of Dijon 2014-2022 - Elected to the Scientific Council of the IUT of Dijon 2006-2012 - vice-president of the recruitment committee (section 64 Biochemistry-Molecular Biology) of the University of Bourgogne 2002-2004 - President of the AEP-Bio (Association for the Study of Peroxisomes) whose aim is to animate a scientific network and organize scientific meeting every two years on peroxisomal themes. - Co-organizer of the 3rd OEPM (Dijon, 2012), of the 29th Forum of Young Researchers SFBBM (Dijon, 2002) and Organizer of the 11th (Dijon, 2004) and 12th (Paris, 2006) meeting of AEP-Bio **SCIENTIFIC SUMMARY** **Cloning of novel ABC transporters in mammals** ABCA1 - Tangier Disease, Cholesterol efflux ABCB7 - Sideroblastic Anemia ABCG1 - Cholesterol efflux ABCD2 - Closest homolog of ABCD1 which is associated to X-linked adrenoleukodystrophy **ABCD2, a therapeutic target for X-ALD** Transcriptional regulation of ABCD2 PPARalpha pathway, fibrates, fatty acids DHEA, Thyroid hormone and thyromimetics as inducers Phenyl butyrate and chromatin remodeling LXR antagonists **Structure-function analysis of ABCD2** Substrate specificity Functional redundancy Oligomerization **Microglia and physiopathogenesis of X-ALD** Establishment of BV2 microglial mutant cell lines using CRISPR-mediated edition of ABCD1, ABCD2 and ACOX1genes Biochemical and functional characterization (lipids, membrane properties, phagocytosis, cytokines, ...) Co-culture with oligodendrocytes or neurons (link between microglial peroxisomes and demyelination) Co-culture with T lymphocytes (link between microglial peroxisomes and immune response) **Peroxisome, lipid sensing and control of food intake (from Jan 2024)**

Domaines de recherche

Biochimie, Biologie Moléculaire Neurosciences

Compétences

Publications

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Microgliosis: a double‐edged sword in the control of food intake

Juliette Salvi , Pierre Andreoletti , Etienne Audinat , Eglantine Balland , Selma Ben Fradj
FEBS Journal, 2024, 291 (4), pp.615-631. ⟨10.1111/febs.16583⟩
Article dans une revue hal-03739689v1
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Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in Acox1−/− and Wild-Type BV-2 Microglial Cells

Soukaina Essadek , Catherine Gondcaille , Stéphane Savary , Mohammad Samadi , Joseph Vamecq
Antioxidants , 2023, 12 (1), pp.168. ⟨10.3390/antiox12010168⟩
Article dans une revue hal-03994321v1
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Peroxisomal defects in microglial cells induce a disease-associated microglial signature

Quentin Raas , Ali Tawbeh , Mounia Tahri-Joutey , Catherine Gondcaille , Céline Keime
Frontiers in Molecular Neuroscience, 2023, 16 (Sec. Brain Disease Mechanisms), pp.1170313. ⟨10.3389/fnmol.2023.1170313⟩
Article dans une revue hal-04092819v1
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Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation

Ali Tawbeh , Quentin Raas , Mounia Tahri-Joutey , Céline Keime , Romain Kaiser
Frontiers in Molecular Neuroscience, 2023, 16, pp.1299314. ⟨10.3389/fnmol.2023.1299314⟩
Article dans une revue hal-04352894v1
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Protective Effect of Nopal Cactus (Opuntia ficus-indica) Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver

Mounia Tahri-Joutey , Fatima-Ezzahra Saih , Riad El Kebbaj , Catherine Gondcaille , Joseph Vamecq
International Journal of Molecular Sciences, 2022, 23 (19), pp.11849. ⟨10.3390/ijms231911849⟩
Article dans une revue hal-04342093v1
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Peroxisomal ABC Transporters: An Update

Ali Tawbeh , Catherine Gondcaille , Doriane Trompier , Stéphane Savary
International Journal of Molecular Sciences, 2021, 22 (11), pp.6093. ⟨10.3390/ijms22116093⟩
Article dans une revue hal-04344446v1
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Do ABC transporters regulate plasma membrane organization?

Ambroise Wu , Karolina Wojtowicz , Stéphane Savary , Yannick Hamon , Tomasz Trombik
Cellular and Molecular Biology Letters, 2020, 25 (1), ⟨10.1186/s11658-020-00224-x⟩
Article dans une revue hal-02997365v1
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Peroxisomes in Immune Response and Inflammation

Francesca Di Cara , Pierre Andreoletti , Doriane Trompier , Anne Vejux , Margret H Bülow
International Journal of Molecular Sciences, 2019, 20 (16), ⟨10.3390/ijms20163877⟩
Article dans une revue hal-04346483v1

CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy

Q. Raas , C. Gondcaille , Y. Hamon , V. Leoni , C. Caccia
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (5), pp.704-714. ⟨10.1016/j.bbalip.2019.02.006⟩
Article dans une revue hal-02359446v1

A microglial cell model for acyl-CoA oxidase 1 deficiency

Q. Raas , F-E Saih , C. Gondcaille , D. Trompier , Y. Hamon
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩
Article dans une revue hal-02359450v1

Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells.

Meryam Debbabi , Thomas Nury , Imen Helali , El Mostafa Karym , Flore Geillon
Methods in Molecular Biology, 2017, 1595, pp.257-265. ⟨10.1007/978-1-4939-6937-1_25⟩
Article dans une revue hal-01539021v1

Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters

Pierre Andreoletti , Quentin Raas , Catherine Gondcaille , Mustapha Cherkaoui-Malki , Doriane Trompier
International Journal of Molecular Sciences, 2017, 18 (7), pp.1593. ⟨10.3390/ijms18071593⟩
Article dans une revue hal-04342713v1

Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158 N murine oligodendrocytes

Amira Zarrouk , Thomas Nury , El-Mostafa Karym , Anne Vejux , Randa Sghaier
Journal of Steroid Biochemistry and Molecular Biology, 2017, 169, pp.29-38. ⟨10.1016/j.jsbmb.2016.02.024⟩
Article dans une revue hal-04342669v1

Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain

Alice Monnier , Anne Prigent-Tessier , Aurore Quirie , Nathalie Bertrand , Stéphane Savary
Acta Physiologica, 2017, 219 (4), pp.790-802. ⟨10.1111/apha.12743⟩
Article dans une revue hal-01414943v1
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Peroxisomal ATP-binding cassette transporters form mainly tetramers

Flore Geillon , Catherine Gondcaille , Quentin Raas , Alexandre M M Dias , Delphine Pecqueur
Journal of Biological Chemistry, 2017, 292 (17), pp.6965-6977. ⟨10.1074/jbc.M116.772806⟩
Article dans une revue hal-02329531v1
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LXR antagonists induce ABCD2 expression

Catherine Gondcaille , Emmanuelle C. Genin , Tatiana E. Lopez , Alexandre M.M. Dias , Flore Geillon
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2014, 1841 (2), pp.259-266. ⟨10.1016/j.bbalip.2013.11.003⟩
Article dans une revue hal-01185659v1
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Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers

Flore Geillon , Catherine Gondcaille , Soëli Charbonnier , Carlo W. van Roermund , Tatiana E. Lopez
Journal of Biological Chemistry, 2014, 289 (35), pp.24511-24520. ⟨10.1074/jbc.M114.575506⟩
Article dans une revue hal-01223550v1
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Brain Peroxisomes

Doriane Trompier , A. Vejux , A. Zarrouk , Catherine Gondcaille , Flore Geillon
Biochimie, 2013, 98, pp.102-110. ⟨10.1016/j.biochi.2013.09.009⟩
Article dans une revue hal-01185043v1

Peroxisomal ABC transporters and X-linked adrenoleukodystrophy

Flore Geillon , Doriane Trompier , Catherine Gondcaille , Gérard Lizard , Stéphane Savary
Médecine/Sciences, 2012, 28 (12), pp.1087-1094. ⟨10.1051/medsci/20122812019⟩
Article dans une revue hal-01221377v1
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Substrate specificity overlap and interaction between Adrenoleukodystrophy protein (ALDP/ABCD1) and Adrenoleukodystrophy-related protein (ALDRP/ABCD2)

Emmanuelle C. Genin , Flore Geillon , Catherine Condcaille , Anne Athias , Philippe Gambert
Journal of Biological Chemistry, 2011, 286 (10), pp.8075-8084. ⟨10.1074/jbc.M110.211912⟩
Article dans une revue hal-01221369v1
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Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes.

Mauhamad Baarine , Kevin Ragot , Emmanuelle C. Genin , Hammam El Hajj , Doriane Trompier
Journal of Neurochemistry, 2009, 111 (1), pp.119-31. ⟨10.1111/j.1471-4159.2009.06311.x⟩
Article dans une revue hal-00514890v1

Exon organisation of the mouse gene encoding the Adrenoleukodystrophy related protein (ALDRP)

Cyril Broccardo , Nathalie Troffer-Charlier , Stephane Savary , Jean-Louis Mandel , Giovanna Chimini
European Journal of Human Genetics, 1998, 6, pp.638-641. ⟨10.1038/sj.ejhg.5200233⟩
Article dans une revue hal-04022404v1

Chromosomal localization of the adrenoleukodystrophy-related gene in man and mice

Stéphane Savary , Nathalie Troffer-Charlier , Gabor Gyapay , Marie-Geneviève Mattei , Giovanna Chimini
European Journal of Human Genetics, 1997, 5 (2), pp.99-101
Article dans une revue hal-03832784v1

Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene

S. Savary , F. Denizot , M. -F. Luciani , M. -G. Mattei , G. Chimini
Mammalian Genome, 1996, 7 (9), pp.673-676. ⟨10.1007/s003359900203⟩
Article dans une revue hal-04342137v1

Cloning of Two Novel ABC Transporters Mapping on Human Chromosome 9

Marie Françoise Luciani , François Denizot , Stéphane Savary , Marie Geneviève Mattei , Giovanna Chimini
Genomics, 1994, 21 (1), pp.150-159. ⟨10.1006/geno.1994.1237⟩
Article dans une revue hal-04342121v1

X-linked Adrenoleukodystrophy

Doriane Trompier , Stéphane Savary
Morgan & Claypool Publishers, 2 (1), pp.1-134, 2013, Genetic Basis of Disease, Michael Dean, 9781615045549
Ouvrages hal-04345336v1