Stephane Savary

Stéphane SAVARY

CSGA UMR6265 CNRS, 1324 INRAE, Institut Agro Dijon, Université Bourgogne Europe Equipe NeuroFeed 9E, boulevard Jeanne d'Arc, 21000 Dijon, France https://csga.fr/

POSITIONS AND EMPLOYMENT Since 2012: Professor of Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne 1998-2012 : Associate Professor, Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne 1996-1998 : Assistant Professor, Molecular Biology, University of Tours, Postdoc in the Research Institute of Insect Biology, Genomic relationship between the wasp Cotesia congregata and its symbiotic polydnavirus.

EDUCATION AND TRAINING 2004 - Habilitation to Supervise Researches, Univeristy of Bourgogne, “Cloning and characterization of the ABCD2 gene: therapeutic hope for adrenoleukodystrophy” 1996 - PhD. Immunology, University of the Mediterranean Marseille, France, CIML, Identification and characterization of novel ABC transporters in mammals. 1993 - MS Immunology, University of the Mediterranean Marseille, France 1989-1992 - BS,MS Biochemistry, University of the Mediterranean Marseille, France

THESIS AND MASTER SUPERVISION Supervisor of 8 PhD students Supervisor of 10 Master students Supervisor of 2 postdoctoral fellows

RESEARCH RESPONSABILITIES 2023 : Director of the Lab. BioperoxIL, EA7270 University of Bourgogne 2017-2023: Deputy Director of BioperoxIL 2004-2023: Head of the research group “ABCD transporters and X-ALD”, BioperoxIL

PUBLICATIONS http://www.researcherid.com/rid/C-8137-2011 52 publications since 1994, average citation per article 35, Average iF 5,1 , h-index 23 (Jan 2025)

OTHER EXPERIENCES AND PROFESSIONAL MEMBERSHIP

• President of the BCP 64/65 University Bourgogne Europe
• Elected to the Administrative Council of the IUT of Dijon 2018-2022
• Member of the concil of the Doctoral School Environment-Health of the University of Bourgogne-Franche-Comté since 2017 (https://e2s.ubfc.fr/)
• Elected to the Comission of human ressources of the IUT of Dijon 2014-2022
• Elected to the Scientific Council of the IUT of Dijon 2006-2012
• vice-president of the recruitment committee (section 64 Biochemistry-Molecular Biology) of the University of Bourgogne 2002-2004
• President of the AEP-Bio (Association for the Study of Peroxisomes) whose aim is to animate a scientific network and organize scientific meeting every two years on peroxisomal themes.
• Co-organizer of the 3rd OEPM (Dijon, 2012), of the 29th Forum of Young Researchers SFBBM (Dijon, 2002) and Organizer of the 11th (Dijon, 2004) and 12th (Paris, 2006) meeting of AEP-Bio

SCIENTIFIC SUMMARY Cloning of novel ABC transporters in mammals ABCA1 - Tangier Disease, Cholesterol efflux https://omim.org/entry/600046 ABCB7 - Sideroblastic Anemia https://omim.org/entry/300135 ABCG1 - Cholesterol efflux https://omim.org/entry/603076 ABCD2 - Closest homolog of ABCD1, whose defect is associated with X-linked adrenoleukodystrophy https://omim.org/entry/601081

ABCD2, a therapeutic target for X-ALD Transcriptional regulation of the Abcd2 gene PPARalpha pathway, fibrates, fatty acids DHEA, Thyroid hormone and thyromimetics as inducers Phenyl butyrate and chromatin remodeling LXR antagonists

Structure-function analysis of ABCD2 Substrate specificity Functional redundancy Oligomerization

Microglia and physiopathogenesis of X-ALD Establishment of BV2 microglial mutant cell lines using CRISPR-mediated edition of Abcd1, Abcd2, Acox1 genes Biochemical and functional characterization (lipids, membrane properties, phagocytosis, cytokines, ...) Co-culture with oligodendrocytes or neurons (link between microglial peroxisomes and neurodegeneration) Co-culture with T lymphocytes (link between microglial peroxisomes and immune response)

Peroxisome, lipid sensing and control of food intake (from Jan 2024)