Stephane Savary
Professeur des Universités en Biochimie et Biologie Moléculaire
73%
Libre accès
26
Documents
Affiliations actuelles
- 1096468
Identifiants chercheurs
- stephane-savary
- 0000-0002-9237-1727
- IdRef : 071035044
- ResearcherId : C-8137-2011
- ResearcherId : http://www.researcherid.com/rid/C-8137-2011
Présentation
**Stéphane SAVARY**
CSGA
UMR6265 CNRS, 1324 INRAE, Institut Agro Dijon, Université de Bourgogne
Equipe 5, Neurobiologie des Comportements Alimentaires
9E, boulevard Jeanne d'Arc, 21000 Dijon, France
https://www2.dijon.inrae.fr/csga/
**POSITIONS AND EMPLOYMENT**
Since 2012: Professor of Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne
1998-2012 : Associate Professor, Biochemistry and Molecular Biology, IUT Dijon, University of Bourgogne
1996-1998 : Assistant Professor, Molecular Biology, University of Tours, Postdoc in the Research Institute of Insect Biology, Genomic relationship between the wasp Cotesia congregata and its symbiotic polydnavirus.
**EDUCATION AND TRAINING**
2004 - Habilitation to Supervise Researches, Univeristy of Bourgogne, “Cloning and characterization of the ABCD2 gene: therapeutic hope for adrenoleukodystrophy”
1996 - PhD. Immunology, University of the Mediterranean Marseille, France, CIML, Identification and characterization of novel ABC transporters in mammals.
1993 - MS Immunology, University of the Mediterranean Marseille, France
1989-1992 - BS,MS Biochemistry, University of the Mediterranean Marseille, France
**THESIS AND MASTER SUPERVISION**
Supervisor of 8 PhD students
Supervisor of 10 Master students
Supervisor of 2 postdoctoral fellows
**RESEARCH RESPONSABILITIES**
2023 : Director of the Lab. BioperoxIL, EA7270 University of Bourgogne
2017-2023: Deputy Director of BioperoxIL
2004-2023: Head of the research group “ABCD transporters and X-ALD”, BioperoxIL
**PUBLICATIONS**
http://www.researcherid.com/rid/C-8137-2011
49 publications since 1994, average citation per article 30, Average iF 5,2 , h-index 21 (Jan 2024)
**OTHER EXPERIENCES AND PROFESSIONAL MEMBERSHIP**
- President of the BCP 64/65 University of Bourgogne
- Elected to the Administrative Council of the IUT of Dijon 2018-2022
- Member of the concil of the Doctoral School Environment-Health of the University of Bourgogne-Franche-Comté since 2017 (http://www.ecoledoctoralee2s.com/)
- Elected to the Comission of human ressources of the IUT of Dijon 2014-2022
- Elected to the Scientific Council of the IUT of Dijon 2006-2012
- vice-president of the recruitment committee (section 64 Biochemistry-Molecular Biology) of the University of Bourgogne 2002-2004
- President of the AEP-Bio (Association for the Study of Peroxisomes) whose aim is to animate a scientific network and organize scientific meeting every two years on peroxisomal themes.
- Co-organizer of the 3rd OEPM (Dijon, 2012), of the 29th Forum of Young Researchers SFBBM (Dijon, 2002) and Organizer of the 11th (Dijon, 2004) and 12th (Paris, 2006) meeting of AEP-Bio
**SCIENTIFIC SUMMARY**
**Cloning of novel ABC transporters in mammals**
ABCA1 - Tangier Disease, Cholesterol efflux
ABCB7 - Sideroblastic Anemia
ABCG1 - Cholesterol efflux
ABCD2 - Closest homolog of ABCD1 which is associated to X-linked adrenoleukodystrophy
**ABCD2, a therapeutic target for X-ALD**
Transcriptional regulation of ABCD2
PPARalpha pathway, fibrates, fatty acids
DHEA, Thyroid hormone and thyromimetics as inducers
Phenyl butyrate and chromatin remodeling
LXR antagonists
**Structure-function analysis of ABCD2**
Substrate specificity
Functional redundancy
Oligomerization
**Microglia and physiopathogenesis of X-ALD**
Establishment of BV2 microglial mutant cell lines using CRISPR-mediated edition of ABCD1, ABCD2 and ACOX1genes
Biochemical and functional characterization (lipids, membrane properties, phagocytosis, cytokines, ...)
Co-culture with oligodendrocytes or neurons (link between microglial peroxisomes and demyelination)
Co-culture with T lymphocytes (link between microglial peroxisomes and immune response)
**Peroxisome, lipid sensing and control of food intake (from Jan 2024)**
Domaines de recherche
Biochimie, Biologie Moléculaire
Neurosciences
Compétences
Publications
X-linked AdrenoleukodystrophyMorgan & Claypool Publishers, 2 (1), pp.1-134, 2013, Genetic Basis of Disease, Michael Dean, 9781615045549
Ouvrages
hal-04345336v1
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