Thibaut LARCHER

107
Documents
Affiliations actuelles
  • Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
  • École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)
Identifiants chercheurs
Contact

Présentation

As a veterinary pathologist, I have been in charge since 2007 of the setting up and the development of an academic platform in Nantes, called APEX, dedicated to comparative pathology and animal tissue phenotyping. I have years’ experience in veterinary histopathology, in the identification of tissular biomarkers and in the development of specific labelling and quantitative methods for lesion assessment. I was involved in clinical and pathological evaluation of many animal models (including zebrafish, rodents, pigs, dogs and Non-Human Primates). As a member of the European college of Veterinary pathologist (ECVP), my expertise is recognized by drug regulatory agencies (FDA, EMA). I contributed to preclinical efficacy and safety evaluation of gene and cell therapy protocols (AAV- and muscle-derived stem cell-based ones) and other innovative treatments against viral infectious diseases and tumours for academic and private collaborators. I am the author or co-author of more than 115 articles published in peer-reviewed journals.

Domaines de recherche

Médecine vétérinaire et santé animale

Compétences

Histopathologie Microscopie Analyse d'image Médecine vétérinaire Pathologie comparée Anatomopathologie Anatomie

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Publications

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Swine influenza A virus infection sets the local immunological landscape in subsequent infection with porcine reproductive and respiratory syndrome virus

Janaïna Grevelinger , Olivier Bourry , Selma Schmidt , François Meurens , Céline Deblanc et al.
Veterinary Research, 2025, 56 (1), pp.114. ⟨10.1186/s13567-025-01536-6⟩
Article dans une revue hal-05103379 v1

The prion-family protein Doppel exerts a protective role during influenza virus infection

Soraya Dinant , Johan Castille , Charlotte Deloizy , Elise Bruder , Laura Sedano et al.
Journal of Immunology, 2025, pp.1-13. ⟨10.1093/jimmun/vkaf031⟩
Article dans une revue hal-05029118 v1

Omega-3 Fatty Acid and Vitamin D Supplementations Partially Reversed Metabolic Disorders and Restored Gut Microbiota in Obese Wistar Rats

Dylan Le Jan , Mohamed Siliman Misha , Sandrine Destrumelle , Olivia Terceve , Chantal Thorin et al.
Biology, 2024, 13 (12), pp.1070. ⟨10.3390/biology13121070⟩
Article dans une revue hal-04996002 v1
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Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina

Aurélien Leray , Pierre-Alban Lalys , Juliette Varin , Mohammed Bouzelha , Audrey Bourdon et al.
Biomedicine and Pharmacotherapy, 2024, 171, pp.116148. ⟨10.1016/j.biopha.2024.116148⟩
Article dans une revue hal-04781485 v1
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Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak

Wilson Nguyen , Narayan Gyawali , Romal Stewart , Bing Tang , Abigail L. Cox et al.
npj Viruses, 2024, 2 (1), pp.15. ⟨10.1038/s44298-024-00025-5⟩
Article dans une revue hal-04597740 v1
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Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Svenja Sake , Xiaoyu Zhang , Manoj Kumar Rajak , Melanie Urbanek-Quaing , Arnaud Carpentier et al.
Nature Communications, 2024, 15 (1), pp.1173. ⟨10.1038/s41467-024-45241-y⟩
Article dans une revue hal-04504093 v1
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The caecal microbiota promotes the acute inflammatory response and the loss of the intestinal barrier integrity during severe Eimeria tenella infection

Florian Tomal , Guillaume Sadrin , Pauline Gaboriaud , Edouard Guitton , Laura Sedano et al.
Frontiers in Cellular and Infection Microbiology, 2023, 13, pp.1250080. ⟨10.3389/fcimb.2023.1250080⟩
Article dans une revue hal-04187670 v1
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Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers

Petra ter Brugge , Sarah Moser , Ivan Bièche , Petra Kristel , Sabrina Ibadioune et al.
Nature Communications, 2023, 14 (1), pp.1958. ⟨10.1038/s41467-023-37537-2⟩
Article dans une revue hal-04072477 v1
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Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers

Rania El-Botty , Ludivine Morriset , Elodie Montaudon , Zakia Tariq , Anne Schnitzler et al.
Nature Communications, 2023, 14 (1), pp.4221. ⟨10.1038/s41467-023-40022-5⟩
Article dans une revue hal-04205847 v1
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Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases

Tristan Méric , Julien Issard , Thomas Maufras , Marine Hugonnard , Odile Senecat et al.
Journal of Veterinary Internal Medicine, 2023, 37 (6), pp.2375-2384. ⟨10.1111/jvim.16876⟩
Article dans une revue hal-04234504 v1
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Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms

Muhammad Farooq , Melanie Simoes Eugenio , Claire Piquet-Pellorce , Sarah Dion , Celine Raguenes-Nicol et al.
Journal of Molecular Medicine, 2022, 100 (7), pp.1027-1038. ⟨10.1007/s00109-022-02192-5⟩
Article dans une revue hal-03711624 v1
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Myopathy with oval inclusions in a domestic shorthair cat

Eliot Gougeon , Thibaut Larcher , Mireille Ledevin , Yvonne Mcgrotty , Pierre Méheust
Journal of Feline Medicine and Surgery Open Reports, 2022, 8 (1), pp.205511692210814. ⟨10.1177/20551169221081418⟩
Article dans une revue hal-03620285 v1
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Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMDmdx rat model

Audrey Bourdon , Virginie François , Liwen Zhang , Aude Lafoux , Bodvael Fraysse et al.
Gene Therapy, 2022, 29 (9), pp.520-535. ⟨10.1038/s41434-022-00317-6⟩
Article dans une revue hal-03838616 v1
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Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotides

Karima Relizani , Lucía Echevarría , Faouzi Zarrouki , Cécile Gastaldi , Chloe Dambrune et al.
Nucleic Acids Research, 2022, 50 (1), pp.:17-34. ⟨10.1093/nar/gkab1199⟩
Article dans une revue hal-03476811 v1

Receptor‑interacting protein kinase‑1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms

Muhammad Akmal Farooq , Melanie Simoes Eugenio , Claire Picquet-Pellorce , Sarah Dion , Céline Raguénès-Nicol et al.
Journal of Molecular Medicine, 2022
Article dans une revue hal-03635249 v1
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In vivo imaging reveals novel replication sites of a highly oncogenic avian herpesvirus in chickens

Isabelle Lantier , Corentin Mallet , Laurent Souci , Thibaut Larcher , Andele Conradie et al.
PLoS Pathogens, 2022, 18 (8), 28 p. ⟨10.1371/journal.ppat.1010745⟩
Article dans une revue hal-03775131 v1
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New Look at RSV Infection: Tissue Clearing and 3D Imaging of the Entire Mouse Lung at Cellular Resolution

Maxence Frétaud , Delphyne Descamps , Daphné Laubret , Marie-Anne Rameix-Welti , Jean-François Eléouët et al.
Viruses, 2021, 13 (2), pp.201. ⟨10.3390/v13020201⟩
Article dans une revue hal-03159667 v1
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Effects of metals and persistent organic pollutants on the fitness and health of juveniles of the endangered European sturgeon Acipenser sturio exposed to water and sediments of the Garonne and Dordogne rivers

J. Lucas , C. Lefrancois , Charline Gesset , H. Budzinski , P. Labadie et al.
Ecotoxicology and Environmental Safety, 2021, 225, pp.112720. ⟨10.1016/j.ecoenv.2021.112720⟩
Article dans une revue hal-03373747 v1
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Oxythermal window drastically constraints the survival and development of European sturgeon early life phases

Nicolas Delage , Blandine Couturier , Philippe Jatteau , Thibaut Larcher , Mireille Ledevin et al.
Environmental Science and Pollution Research, 2020, 27, ⟨10.1007/s11356-018-4021-8⟩
Article dans une revue hal-02091624 v1
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Direct and indirect effects of multiple environmental stressors on fish health in human-altered rivers

Quentin Petitjean , Séverine Jean , Jessica Côte , Thibaut Larcher , Frédéric Angelier et al.
Science of the Total Environment, 2020, 742, pp.140657. ⟨10.1016/j.scitotenv.2020.140657⟩
Article dans une revue hal-02898178 v1
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A Yellow Fever Virus 17D Infection and Disease Mouse Model Used to Evaluate a Chimeric Binjari-Yellow Fever Virus Vaccine

Kexin Yan , Laura J Vet , Bing Tang , Jody Hobson-Peters , Daniel J Rawle et al.
Vaccines 2020, 2020, 8, ⟨10.3390/vaccines8030368⟩
Article dans une revue hal-02898172 v1

PCV2 co-infection does not impact PRRSV MLV1 safety but enhances virulence of a PRRSV MLV1-like strain in infected SPF pigs

Julie Eclercy , Thibaut Larcher , Mathieu Andraud , Patricia Renson , Cécilia Bernard et al.
Veterinary Microbiology, 2020, 244, pp.108656. ⟨10.1016/j.vetmic.2020.108656⟩
Article dans une revue hal-02561973 v1
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Characterization of brain dystrophins absence and impact in dystrophin-deficient Dmdmdx rat model

Dorian Caudal , Virginie François , Aude Lafoux , Mireille Ledevin , Ignacio Anegon et al.
PLoS ONE, 2020, 15 (3), pp.e0230083. ⟨10.1371/journal.pone.0230083⟩
Article dans une revue hal-02509545 v1
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Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice

Marie Galloux , Nadège Gsponer , Vanessa Gaillard , Brice Fenner , Thibaut Larcher et al.
Antimicrobial Agents and Chemotherapy, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩
Article dans une revue hal-03353101 v1
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The Absence of Gut Microbiota Alters the Development of the Apicomplexan Parasite Eimeria tenella

Pauline Gaboriaud , Guillaume Sadrin , Edouard Guitton , Geneviève Fort , Alisson Niepceron et al.
Frontiers in Cellular and Infection Microbiology, 2020, 10, pp.632556. ⟨10.3389/fcimb.2020.632556⟩
Article dans une revue hal-03156323 v1
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BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

Florence Coussy , Rania El-Botty , Sophie Château-Joubert , Ahmed Dahmani , Elodie Montaudon et al.
Science Translational Medicine, 2020, 12 (531), pp.eaax2625. ⟨10.1126/scitranslmed.aax2625⟩
Article dans une revue hal-02508765 v1
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PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

Elodie Montaudon , Joanna Nikitorowicz-Buniak , Laura Sourd , Ludivine Morisset , Rania El Botty et al.
Nature Communications, 2020, 11, ⟨10.1038/s41467-020-17697-1⟩
Article dans une revue hal-02933439 v1
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Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?

Karim Bey , Johan Deniaud , Laurence Dubreil , Béatrice Joussemet , Joseph Cristini et al.
Molecular Therapy - Methods and Clinical Development, 2020, 17, pp.771-784. ⟨10.1016/j.omtm.2020.04.001⟩
Article dans une revue hal-02561949 v2
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Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers

F. Coussy , R. El Botty , M. Lavigne , C. Gu , L. Fuhrmann et al.
Journal of Hematology and Oncology, 2020, 13 (1), ⟨10.1186/s13045-020-0846-y⟩
Article dans une revue hal-02508763 v1
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Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts

Florence Coussy , Marion Lavigne , Leanne de Koning , Rania El Botty , Fariba Nemati et al.
Theranostics, 2020, 10 (4), pp.1531-1543. ⟨10.7150/thno.36182⟩
Article dans une revue hal-02509541 v1
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5 years of successful inducible transgene expression following locoregional AAV delivery in nonhuman primates with no detectable immunity

Mickael Guilbaud , Marie Devaux , Célia Couzinié , Johanne Le Duff , Alice Toromanoff et al.
Human Gene Therapy, 2019, ⟨10.1089/hum.2018.234⟩
Article dans une revue hal-02091623 v1
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Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment

Laure-Hélène Ouisse , Severine Remy , Aude Lafoux , Thibaut Larcher , Laurent Tesson et al.
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.02131⟩
Article dans une revue inserm-02341819 v1
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Assessment of pulmonary tissue responses in pigs challenged with PRRSV Lena strain shows better protection after immunization with field than vaccine strains

Thibaut Larcher , Christelle Fablet , Patricia Renson , Déborah Menard , Caroline Hervet et al.
Veterinary Microbiology, 2019, 230, pp.249-259. ⟨10.1016/j.vetmic.2019.01.022⟩
Article dans une revue hal-02061157 v1
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Macrophage-B Cell Interactions in the Inverted Porcine Lymph Node and Their Response to Porcine Reproductive and Respiratory Syndrome Virus

Elise Bordet , Maxence Fretaud , Elisa Crisci , Edwige Bouguyon , Stephane Rault et al.
Frontiers in Immunology, 2019, 10, pp.953. ⟨10.3389/fimmu.2019.00953⟩
Article dans une revue hal-02164040 v1
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VEGF-A inhibition as a potential therapeutic approach in Merkel cell carcinoma

Thibault Kervarrec , Pauline Gaboriaud , A. Tallet , Valérie Leblond , Françoise Arnold et al.
Journal of Investigative Dermatology, 2019, 139 (3), pp.736-739. ⟨10.1016/j.jid.2018.08.029⟩
Article dans une revue hal-02621891 v1
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A large collection of integrated genomically characterized patient‐derived xenografts highlighting the heterogeneity of triple‐negative breast cancer

Florence Coussy , Leanne Koning , Marion Lavigne , Virginie Bernard , Berengere Ouine et al.
International Journal of Cancer, 2019, ⟨10.1002/ijc.32266⟩
Article dans une revue hal-02093370 v1

5 years of successful inducible transgene expression following locoregional AAV delivery in nonhuman primates with no detectable immunity

Mickaël Guilbaud , Marie Devaux , Célia Couzinié , Johanne Le Duff , Alice Toromanoff et al.
Human Gene Therapy, 2019
Article dans une revue inserm-02052292 v1
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Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate

Natalie Prow , Thiago Hirata , Bing Tang , Thibaut T. Larcher , Pamela Mukhopadhyay et al.
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.02736⟩
Article dans une revue hal-02885399 v1

fixation et inclusion en paraffine de tissus d'abeille pour une observation histologique

Mireille Ledevin , Monique L'Hostis , Thibaut Larcher
Revue Française d'Histotechnologie, 2018, 30 (1), pp.17-30
Article dans une revue hal-01867045 v1
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Atrophy of primary lymphoid organs induced by Marek's disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia

Camille Berthault , Thibaut Larcher , Sonja Härtle , Jean-François Vautherot , Laëtitia Trapp-Fragnet et al.
Veterinary Research, 2018, 49 (1), pp.1-18. ⟨10.1186/s13567-018-0526-x⟩
Article dans une revue hal-02628278 v1
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Satellite cells fail to contribute to muscle repair but are functional in Pompe disease (glycogenosis type II).

Lydie Lagalice , Julien Pichon , Eliot Gougeon , Salwa Soussi , Johan Deniaud et al.
Acta Neuropathologica Communications, 2018, 6 (1), pp.116. ⟨10.1186/s40478-018-0609-y⟩
Article dans une revue hal-02623544 v1
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Exploring multiple effects of Zn0.15Mg0.85O nanoparticles on Bacillus subtilis and macrophages

Sandrine Auger , Céline Henry , Christine Longin , Sneha Suman , Nathalie Lejal et al.
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-30719-9⟩
Article dans une revue hal-01867036 v1
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Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens

Sascha Trapp , Denis Soubieux , Alexandra Lidove , Evelyne Esnault , Adrien Lion et al.
Virology Journal, 2018, 15, pp.1-12. ⟨10.1186/s12985-018-0960-4⟩
Article dans une revue hal-02626011 v1
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Vascular Delivery of Allogeneic MuStem Cells in Dystrophic Dogs Requires Only Short-Term Immunosuppression to Avoid Host Immunity and Generate Clinical/Tissue Benefits

Judith Lorant , Thibaut Larcher , Nicolas Jaulin , Benoit Hedan , Aurélie Lardenois et al.
Cell Transplantation, 2018, 27 (7), pp.1096-1110. ⟨10.1177/0963689718776306⟩
Article dans une revue hal-01812518 v1
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A short double-stapled peptide inhibits respiratory syncytial virus entry and spreading

Vanessa Gaillard , Marie Galloux , Dominique Garcin , Jean Francois Eleouet , Ronan Le Goffic et al.
Antimicrobial Agents and Chemotherapy, 2017, 61 (4), ⟨10.1128/AAC.02241-16⟩
Article dans une revue hal-01605887 v1
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Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy

Caroline C. Le Guiner , Laurent Servais , Marie Montus , Thibaut Thibaut , Bodvael Fraysse et al.
Nature Communications, 2017, 8 (1), pp.16105. ⟨10.1038/ncomms16105⟩
Article dans une revue hal-02179396 v1
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Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque

Samuel Bitoun , Pierre Roques , Thibaut Larcher , Gaétane Nocturne , Che Serguera et al.
Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.01816⟩
Article dans une revue hal-01701600 v1
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Epicutaneous Tolerance Induction to a Bystander Antigen Abrogates Colitis and Ileitis in Mice

David Dunkin , M. Cecilia Berin , Lucie Mondoulet , Steven Tobar , Garabet Yeretssian et al.
Inflammatory Bowel Diseases, 2017, 23 (11), pp.1972-1982. ⟨10.1097/MIB.0000000000001273⟩
Article dans une revue hal-01701599 v1
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Characterisation of Early-Life Fecal Microbiota in Susceptible and Healthy Pigs to Post-Weaning Diarrhoea

Samir Dou , Pascale Gadonna-Widehem , Véronique Rome , Dounia Hamoudi , Larbi Rhazi et al.
PLoS ONE, 2017, 12 (1), pp.e0169851. ⟨10.1371/journal.pone.0169851⟩
Article dans une revue hal-01525331 v1
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Treatment of gastric eosinophilia by epicutaneous immunotherapy in piglets sensitized to peanuts

L. Mondoulet , N. Kalach , V. Dhelft , Thibaut Larcher , C. Delayre-Orthez et al.
Clinical and Experimental Allergy, 2017, 47 (12), pp.1640-1647. ⟨10.1111/cea.13037⟩
Article dans une revue hal-01701597 v1
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Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action

Caroline Vignet , Thibaut Larcher , Blandine Davail , Lucette Joassard , Karyn Le Menach et al.
Toxics, 2016, 4 (4), pp.26. ⟨10.3390/toxics4040026⟩
Article dans une revue hal-01425791 v1
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Identification in GRMD dog muscle of critical miRNAs involved in pathophysiology and effects associated with MuStem cell transplantation.

Florence Robriquet , Candice Babarit , Thibaut Larcher , Laurence Dubreil , Mireille Ledevin et al.
BMC Musculoskeletal Disorders, 2016, 17 (1), pp.209. ⟨10.1186/s12891-016-1060-5⟩
Article dans une revue hal-01321085 v1

Antioxidant properties of formula derived Maillard reaction products in colons of intrauterine growth restricted pigs

Ghada Elmhiri , Dounia Hamoudi , Samir Dou , Narges Bahi-Jaber , Julie Reygnier et al.
Food and Function, 2016, 7 (6), ⟨10.1039/c5fo01551k⟩
Article dans une revue hal-01310596 v1

Non-invasive epicutaneous vaccine against Respiratory Syncytial Virus: Preclinical proof of concept

Pierre-Louis Hervé , Delphyne Descamps , Charlotte Deloizy , Véronique Dhelft , Daphné Laubreton et al.
Journal of Controlled Release, 2016, 243, pp.146-159. ⟨10.1016/j.jconrel.2016.10.003⟩
Article dans une revue hal-01425790 v1
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Quantitative proteome profiling of dystrophic dog skeletal muscle reveals a stabilized muscular architecture and protection against oxidative stress after systemic delivery of MuStem cells.

Aurélie Lardenois , Sabrina Jagot , Mélanie Lagarrigue , Blandine Guével , Mireille Ledevin et al.
Proteomics, 2016, 16 (14), pp.2028-2042. ⟨10.1002/pmic.201600002⟩
Article dans une revue hal-01332030 v1
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Altered DNA methylation associated with an abnormal liver phenotype in a cattle model with a high incidence of perinatal pathologies

Hélène Kiefer , Luc Jouneau , Evelyne E. Campion , Delphine Rousseau-Ralliard , Thibaut Larcher et al.
Scientific Reports, 2016, 6, pp.38869. ⟨10.1038/srep38869⟩
Article dans une revue hal-02633915 v1

Treatment of colitis by epicutaneous immunotherapy in a murine model

David Dunkin , M Cecilia Berin , Lucie Mondoulet , Zaruhi Hovhannisyan , Alina Iuga et al.
Inflammatory Bowel Diseases, 2016, 22, pp.S5. ⟨10.1097/01.MIB.0000480100.25518.df⟩
Article dans une revue hal-01594622 v1
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Early Interaction of Adeno-Associated Virus Serotype 8 Vector with the Host Immune System Following Intramuscular Delivery Results in Weak but Detectable Lymphocyte and Dendritic Cell Transduction

Gwladys Gernoux , Mickaël Guilbaud , Laurence Dubreil , Thibaut Larcher , Candice Babarit et al.
Human Gene Therapy, 2015, 26 (1), pp.1 - 13. ⟨10.1089/hum.2014.070⟩
Article dans une revue inserm-01734763 v1
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Application of texture analysis to muscle MRI: 1- What kind of information should be expected from texture analysis?

Jacques D. de Certaines , Thibaut Larcher , Dorota Duda , Noura Azzabou , Pierre-Antoine Eliat et al.
European Physical Journal: Applied Physics, 2015, 3 (3), pp.3. ⟨10.1140/s40366-015-0017-1⟩
Article dans une revue hal-01140159 v1

Formula-derived advanced glycation end products are involved in the development of long-term inflammation and oxidative stress in kidney of IUGR piglets.

Ghada Elmhiri , Dler F D Mahmood , Celine Niquet-Leridon , Philippe Jacolot , Stéphane Firmin et al.
Molecular Nutrition and Food Research, 2015, 59 (5), ⟨10.1002/mnfr.201400722⟩
Article dans une revue istex hal-01140160 v1
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Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation

Florence Robriquet , Aurélie Lardenois , Candice Babarit , Thibaut Larcher , Laurence Dubreil et al.
PLoS ONE, 2015, 10 (5), ⟨10.1371/journal.pone.0123336⟩
Article dans une revue hal-01222898 v1
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Infectious chikungunya virus in the saliva of mice, monkeys and humans

Joy Gardner , Penny A. Rudd , Natalie A Prow , Essia Belarbi , Pierre Roques et al.
PLoS ONE, 2015, 10 (10), ⟨10.1371/journal.pone.0139481⟩
Article dans une revue hal-01205627 v1
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MRI texture analysis of GRMD dogs using orthogonal moments : a preliminary study.

G Yang , V Lalande , L Chen , N. Azzabou , Thibaut Larcher et al.
Innovation and Research in BioMedical engineering, 2015, 36 (4), pp.213-219. ⟨10.1016/j.irbm.2015.06.004⟩
Article dans une revue hal-01180288 v1
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Short-lived recombinant adeno-associated virus transgene expression in dystrophic muscle is associated with oxidative damage to transgene mRNA

Jean-Baptiste Dupont , Benoit Tournaire , Christophe Georger , Béatrice Marolleau , Laurence Jeanson-Leh et al.
Molecular Therapy - Methods and Clinical Development, 2015, 27 (3), pp.122-34. ⟨10.1038/mtm.2015.10⟩
Article dans une revue inserm-01799048 v1

Application of texture analysis to muscle MRI: 1-What kind of information should be expected from texture analysis?

Jacques D de Certaines , Thibaut Larcher , Dorota Duda , Noura Azzabou , Pierre-Antoine Eliat et al.
EPJ Nonlinear Biomedical Physics, 2015, 3 (1), pp.1-14. ⟨10.1140/epjnbp/s40366-015-0017-1⟩
Article dans une revue hal-01306718 v1
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In vivo evaluation of cervical stiffness evolution during induced ripening using shear wave elastography, histology and 2 photon excitation microscopy: Insight from an animal model

L. Peralta , Eve Mourier , Christophe Richard , Gilles Charpigny , Thibaut Larcher et al.
PLoS ONE, 2015, 10 (8), pp.1-21. ⟨10.1371/journal.pone.0133377⟩
Article dans une revue hal-01194173 v1

Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation

Florence Robriquet , Aurélie Lardenois , Candice Babarit , Thibaut Larcher , Laurence Dubreil et al.
PLoS ONE, 2015, 10 (5), ⟨10.1371/journal.pone.0123336⟩
Article dans une revue hal-04295557 v1
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Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection

Yee Suan Poo , Penny A. Rudd , Joy Gardner , Jane A. C. Wilson , Thibaut T. Larcher et al.
PLoS Neglected Tropical Diseases, 2014, 8 (12), ⟨10.1371/journal.pntd.0003354⟩
Article dans une revue hal-02633819 v1
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Forelimb Treatment in a Large Cohort of Dystrophic Dogs Supports Delivery of a Recombinant AAV for Exon Skipping in Duchenne Patients

Caroline Le Guiner , Marie Montus , Laurent Servais , Yan Cherel , Virginie François et al.
Molecular Therapy, 2014, 22 (11), pp.1923-1935. ⟨10.1038/mt.2014.151⟩
Article dans une revue inserm-02447482 v1
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CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis

Yee Suan Poo , Helder Nakaya , Joy Gardner , Thibaut Larcher , Wayne Schroder et al.
Journal of Virology, 2014, 88 (12), pp.6862-6872. ⟨10.1128/JVI.03364-13⟩
Article dans une revue hal-01222894 v1

UCP1 is present in porcine adipose tissue and is responsive to postnatal leptin

Alison Mostyn , Linda Attig , Thibaut T. Larcher , Samir Dou , Pascale Chavatte-Palmer et al.
Journal of Endocrinology, 2014, 223 (1), pp.M31-M38. ⟨10.1530/JOE-14-0155⟩
Article dans une revue hal-02632643 v1
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Characterization of Dystrophin Deficient Rats: A New Model for Duchenne Muscular Dystrophy

Thibaut Larcher , Aude Lafoux , Laurent Tesson , Severine Remy , Virginie Thepenier et al.
PLoS ONE, 2014, 9 (10), 13 p. ⟨10.1371/journal.pone.0110371⟩
Article dans une revue hal-01190124 v1
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Chronic dietary exposure of zebrafish to PAH mixtures results in carcinogenic but not genotoxic effects

Thibaut Larcher , P. Perrichon , Caroline Vignet , Mireille Ledevin , K. Le Menach et al.
Environmental Science and Pollution Research, 2014, 21 (24), pp.13833-13849. ⟨10.1007/s11356-014-2923-7⟩
Article dans une revue hal-01123338 v1

Comparison of the effects of the dietary addition of two lactic acid bacteria on the development and conformation of sea bass larvae, Dicentrarchus labrax, and the influence on associated microbiota.

Faouzi Lamari , Mathieu Castex , Thibaut T. Larcher , Mireille Ledevin , David Mazurais et al.
Aquaculture, 2013, 376-379, pp.137-145. ⟨10.1016/j.aquaculture.2012.11.016⟩
Article dans une revue hal-02645134 v1
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Deletion of the C-terminal ESEV domain of NS1 does not affect the replication of a low-pathogenic avian influenza virus H7N1 in ducks and chickens

Sebastien Mathieu Soubies , Thomas Hoffmann , Guillaume Croville , Thibaut T. Larcher , Mireille Ledevin et al.
Journal of General Virology, 2013, 94 (1), pp.50-58. ⟨10.1099/vir.0.045153-0⟩
Article dans une revue hal-02648076 v1
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Effect of Experimental Infection with Haemonchus contortus on Parasitological and Local Cellular Responses in Resistant and Susceptible Young Creole Goats

Jean-Christophe Bambou , Thibaut T. Larcher , Willy W. Cei , Pierre-Justin Dumoulin , Nathalie Mandonnet
BioMed Research International , 2013, pp.1-9. ⟨10.1155/2013/902759⟩
Article dans une revue hal-02644024 v1
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Postnatal leptin promotes organ maturation and development in IUGR piglets

Linda Attig , Daphné Brisard , Thibaut Larcher , Michal Mickiewicz , Paul Guilloteau et al.
PLoS ONE, 2013, 8 (5), ⟨10.1371/journal.pone.0064616⟩
Article dans une revue hal-01136703 v2
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Dietary lipid and cholesterol induce ovarian dysfunction and abnormal LH response to stimulation in rabbits

Anne Gaël Cordier , Pauline Leveille , Charlotte Dupont , Anne Couturier-Tarrade , Olivier Picone et al.
PLoS ONE, 2013, 8 (5), pp.1-11. ⟨10.1371/journal.pone.0063101⟩
Article dans une revue hal-01004078 v1
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Variation patterns in individual fish responses to chemical stress among estuaries, seasons and genders: the case of the European flounder (Platichthys flesus) in the Bay of Biscay

Jean Laroche , Olivier Gauthier , Louis Quiniou , Alain Devaux , Sylvie Bony et al.
Environmental Science and Pollution Research, 2013, 20 (2), pp.738-48. ⟨10.1007/s11356-012-1276-3⟩
Article dans une revue istex halsde-00786498 v1

Histopathological lesions and DNA adducts in the liver of European flounder (<em>Platichthys flesus</em>) collected in the Seine estuary versus two reference estuarine systems on the French Atlantic coast

Jerome Cachot , Yan Cherel , Thibaut T. Larcher , Annie Pfohl-Leszkowicz , Jean Laroche et al.
Environmental Science and Pollution Research, 2013, 20 (2), pp.723 - 737. ⟨10.1007/s11356-012-1287-0⟩
Article dans une revue hal-02644574 v1
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Validation of BdCCp2 as a marker for Babesia divergens sexual stages in ticks

Claire Becker , Laurence Malandrin , Thibaut T. Larcher , Alain Chauvin , Emmanuel Bischoff et al.
Experimental Parasitology, 2013, 133 (1), pp.51-56. ⟨10.1016/j.exppara.2012.10.007⟩
Article dans une revue hal-02642668 v1
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Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock

Penny A Rudd , Jane Wilson , Joy Gardner , Thibaut Larcher , Candice Babarit et al.
Journal of Virology, 2012, 86, pp.9888-9898. ⟨10.1128/JVI.00956-12⟩
Article dans une revue hal-01191139 v1

Porcine colon explants in the study of innate immune response to Entamoeba histolytica

Fabienne Girard-Misguich , Mario Delgado-Ortega , Patricia Berthon , Christelle Rossignol , Thibaut T. Larcher et al.
Veterinary Immunology and Immunopathology, 2012, 145 (3-4), pp.611-617. ⟨10.1016/j.vetimm.2012.01.002⟩
Article dans une revue istex hal-02650556 v1

Ingenol mebutate field-directed treatment of UVB damaged skin reduces lesion formation and removes mutant p53 patches

Sarah-Jane Cozzi , Steven M. Ogbourne , Cini James , Heggert G. Rebel , Frank R. de Gruijl et al.
Journal of Investigative Dermatology, 2012, 132 (4), pp.1263-1271. ⟨10.1038/jid.2011.418⟩
Article dans une revue hal-02648779 v1
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Epicutaneous Immunotherapy (EPIT) blocks the allergic esophago-gastro -enteropathy induced by sustaines oral exposure to peanuts in sensitized mice

Lucie Mondoulet , Vincent Dioszeghy , Thibaut T. Larcher , Mélanie Ligouis , Véronique Dhelft et al.
PLoS ONE, 2012, 7 (2), pp.e31967. ⟨10.1371/journal.pone.0031967⟩
Article dans une revue hal-02652477 v1

Long-term food-exposure of zebrafish to PCB mixtures mimicking some environmental situations induces ovary pathology and impairs reproduction ability

Tarek Daouk , Thibaut Larcher , François Roupsard , Laura Lyphout , Cyril Rigaud et al.
Aquatic Toxicology, 2011, 105, pp.270-278. ⟨10.1016/j.aquatox.2011.06.021⟩
Article dans une revue hal-01205024 v1

Systemic delivery of allogenic muscle stem cells induces long-term muscle repair and clinical efficacy in duchenne muscular dystrophy dogs.

Karl Rouger , Thibaut Larcher , Laurence Dubreil , Jack-Yves Deschamps , Caroline Le Guiner et al.
American Journal of Pathology, 2011, 179 (5), pp.2501-18. ⟨10.1016/j.ajpath.2011.07.022⟩
Article dans une revue inserm-00712818 v1

CELL THERAPY OF DUCHENNE MUSCULAR DYSTROPHY: PRECLINICAL TRIAL IN GRMD DOGS

Yan Cherel , Karl Rouger , Thibaut T. Larcher , Laurence Dubreil , Jack-Yves Deschamps et al.
Bulletin de l'Académie Vétérinaire de France, 2011, 164 (3), pp.211 - 216
Article dans une revue hal-02647422 v1
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Towards the establishment of a porcine model to study human amebiasis.

Fabienne Girard-Misguich , Juliette Cognie , Mario Delgado-Ortega , Patricia Berthon , Christelle Rossignol et al.
PLoS ONE, 2011, 6 (12), ⟨10.1371/journal.pone.0028795⟩
Article dans une revue hal-01129611 v1
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A novel chicken lung epithelial cell line: Characterization and response to low pathogenicity avian influenza virus

Evelyne Esnault , Claire Bonsergent , Thibaut Larcher , Bertrand Bed'Hom , Jean-François Vautherot et al.
Virus Research, 2011, 159 (1), pp.32-42. ⟨10.1016/j.virusres.2011.04.022⟩
Article dans une revue hal-01129500 v1

Postnatal leptin is necessary for maturation of numerous organs in newborn rats

Linda L. Attig , Thibaut T. Larcher , Arieh Gertler , Latifa Abdennebi- Najar , Jean Djiane
Organogenesis, 2011, 7 (2), pp.88-94. ⟨10.4161/org.7.2.14871⟩
Article dans une revue hal-02643082 v1

Chikungunya virus arthritis in adult wild-type mice

Joy Gardner , Itaru Anraku , Thuy T. Le , Thibaut T. Larcher , Lee Major et al.
Journal of Virology, 2010, 84 (16), pp.8021-8032. ⟨10.1128/JVI.02603-09⟩
Article dans une revue hal-02663808 v1

A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens

S. Munier , Thibaut T. Larcher , Fleur Cormier-Aline , Denis Soubieux , B. Su et al.
Journal of Virology, 2010, 84 (2), pp.940-952. ⟨10.1128/JVI.01581-09⟩
Article dans une revue hal-02662785 v1

Lack of Immunotoxicity After Regional Intravenous (RI) Delivery of rAAV to Nonhuman Primate Skeletal Muscle

Alice Toromanoff , Oumeya Adjali , Thibaut T. Larcher , Marcelo Hill , Lydie Guigand et al.
Molecular Therapy, 2010, 18 (1), pp.151-160. ⟨10.1038/mt.2009.251⟩
Article dans une revue hal-02666139 v1

Évaluation de trois substituts du formol sur la fixation des tissus biologiques d'animaux

Lydie Guigand , Mireille Ledevin , B. Fernandez , Julie Massonneau , Yan Cherel et al.
Revue Française d'Histotechnologie, 2010, pp.11-24
Article dans une revue hal-02667357 v1

Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages

Karine Labadie , Thibaut T. Larcher , Christophe Joubert , Abdelkrim Mannioui , Benoit Delache et al.
Journal of Clinical Investigation, 2010, 120 (3), pp.894-906. ⟨10.1172/JCI40104⟩
Article dans une revue hal-02665274 v1
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Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions.

Eric Barrey , Elodie Mucher , Nicolas Jeansoule , Thibaut Larcher , Lydie Guigand et al.
BMC Veterinary Research, 2009, 5 (1), pp.29. ⟨10.1186/1746-6148-5-29⟩
Article dans une revue inserm-00663617 v1

Mode of Delivery and Cell Tropism Versus Immunotoxicity of Recombinant AAV in Nonhuman Primate

Alice Toromanoff , Oumeya Adjali , Aurélie Moreau , Thibaut T. Larcher , Marcelo Hill et al.
Human Gene Therapy, 2009, 20 (6), pp.663
Article dans une revue hal-02656451 v1
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Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development

Linda L. Attig , Jean Djiane , A. Gertler , Olivier Rampin , Thibaut T. Larcher et al.
AJP - Endocrinology and Metabolism, 2008, 295 (5), pp.E1117-E1125. ⟨10.1152/ajpendo.90542.2008⟩
Article dans une revue hal-02667579 v1

Polysaccharide storage myopathy in Cob Normand draft horses

Thibaut T. Larcher , Bérénice Herszberg , S. Molon-Noblot , Lydie Guigand , Stéphane Chaffaux et al.
Veterinary Pathology, 2008, 45 (2), pp.154-158. ⟨10.1354/vp.45-2-154⟩
Article dans une revue hal-02658616 v1

Persistent left cranial vena cava causing oesophageal obstruction and consequent megaoesophagus in a dog

Thibaut T. Larcher , Jérôme Abadie , Françoise A. Roux , Jack-Yves Deschamps , Monique Wyers
Journal of Comparative Pathology, 2006, 135 (2-3), pp.150-152. ⟨10.1016/j.jcpa.2006.05.002⟩
Article dans une revue istex hal-02664503 v1

Genetic Doping" with erythropoietin cDNA in primate muscle is detectable

Françoise Lasne , Laurent Martin , Jacques de Ceaurriz , Thibaut T. Larcher , Philippe Moullier et al.
Molecular Therapy, 2004, 10 (3), pp.409-410. ⟨10.1016/j.ymthe.2004.07.024⟩
Article dans une revue hal-02680322 v1

Autoimmune anemia in macaques following erythropoietin gene therapy

Pierre Chenuaud , Thibaut T. Larcher , Joseph E. Rabinowitz , Nathalie Provost , Yan Cherel et al.
Blood, 2004, 103 (9), pp.3303-3304. ⟨10.1182/blood-2003-11-3845⟩
Article dans une revue hal-02680802 v1

Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle

Pierre Chenuaud , Thibaut Larcher , Joseph E. Rabinowitz , Nathalie Provost , Béatrice Joussemet et al.
Molecular Therapy, 2004, 9 (3), pp.410-418. ⟨10.1016/j.ymthe.2003.12.015⟩
Article dans une revue hal-02678459 v1

Autopsie des bovins

Yan Cherel , Patrice Couillandeau , Thibaut Larcher , Olivier Lecomte , Christian Spindler
Editions du Point Vétérinaire, 2ème, pp.218, 2017
Ouvrages hal-01806304 v1

Autopsie des bovins

Yan Cherel , Patrice Couillandeau , Olivier Lecomte , Christian Spindler , Thibaut T. Larcher
Editions du Point Vétérinaire, 247 p., 2006, Atlas, 2-86326-229-7 978-2863262290
Ouvrages hal-02824564 v1