|
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3 -Mutant Leukemia
Marie Sabatier
,
Rudy Birsen
,
Laura Lauture
,
Sarah Mouche
,
Paolo Angelino
Journal articles
hal-04166110v1
|
|
Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island
Julie Piron
,
Stéphane Betzi
,
Jessica Pastour
,
Audrey Restouin
,
Remy Castellano
Journal articles
hal-03803766v1
|
|
CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation
Kendall Carrasco
,
Camille Montersino
,
Carine Derviaux
,
Magali Saez-Ayala
,
Laurent Hoffer
Journal articles
hal-03624836v1
|
|
The NANOTUMOR consortium - Towards the Tumor Cell Atlas
Florent Colin
,
Kristine Schauer
,
Ali Hamiche
,
Pierre Martineau
,
Jean-Paul Borg
Journal articles
hal-03169719v1
|
|
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
Lucille Stuani
,
Marie Sabatier
,
Estelle Saland
,
Guillaume Cognet
,
Nathalie Poupin
Journal articles
hal-03563454v1
|
|
Synergy and allostery in ligand binding by HIV-1 Nef
Abdullah Aldehaiman
,
Afaque A Momin
,
Audrey Restouin
,
Luyao Wang
,
Xiaoli Shi
Journal articles
hal-03380308v1
|
|
Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell–mediated antitumor immune response
Aude de Gassart
,
Kieu-Suong Le
,
Patrick Brune
,
Sophie Agaugué
,
Jennifer Sims
Journal articles
inserm-03540734v1
|
|
H3.3K27M Mutation Controls Cell Growth and Resistance to Therapies in Pediatric Glioma Cell Lines
Andria Rakotomalala
,
Quentin Bailleul
,
Clara Savary
,
Mélanie Arcicasa
,
Maud Hamadou
Journal articles
hal-03418323v1
|
|
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
Jeremy Ariey‐bonnet
,
Kendall Carrasco
,
Marion Le Grand
,
Laurent Hoffer
,
Stéphane Betzi
Journal articles
hal-02989358v1
|
|
ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells
Florent Amatore
,
Nicolas Ortonne
,
Marc Lopez
,
Florence Orlanducci
,
Rémy Castellano
Journal articles
hal-03152734v1
|
|
ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells
Florent Amatore
,
Nicolas Ortonne
,
Marc Lopez
,
Florence Orlanducci
,
Rémy Castellano
Journal articles
hal-03623228v1
|
|
A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study
A. Collignon
,
M. A Hospital
,
C. Montersino
,
F. Courtier
,
A. Charbonnier
Journal articles
inserm-03038330v1
|
|
A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency
Chantal Lagresle-Peyrou
,
Aurélien Olichon
,
Hanem Sadek
,
Philippe Roche
,
Claudine Tardy
Journal articles
hal-02545998v1
|
|
ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells
Florent Amatore
,
Nicolas Ortonne
,
Marc Lopez
,
Florence Orlanducci
,
Rémy Castellano
Journal articles
inserm-03038313v1
|
|
Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells
Amélie Fouqué
,
Olivier Delalande
,
Mickael Jean
,
Rémy Castellano
,
Emmanuelle Josselin
Journal articles
hal-02526957v1
|
|
A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells
Abir Arfaoui
,
Claire Rioualen
,
Violette Azzoni
,
Guillaume Pinna
,
Pascal Finetti
Journal articles
hal-02539524v1
|
|
Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach
Laurent Hoffer
,
Yuliia Voitovich
,
Brigitt Raux
,
Kendall Carrasco
,
Christophe Muller
Journal articles
hal-02067797v1
|
|
Cegal Protocol : Evaluation of the Feasibility of a Chemogenomic Approach to Identify Personalized Therapy for Relapse or Refractory AML Patients
Norbert Vey
,
Marie Anne Hospital
,
Aude Collignon
,
Yves Collette
,
Daniel Birnbaum
Journal articles
hal-02143630v1
|
|
Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities
Aude Le Roy
,
Thomas Prebet
,
Remy Castellano
,
Armelle Goubard
,
Florence Riccardi
Journal articles
hal-01791593v1
|
|
JAM-C Identifies Src Family Kinase-Activated Leukemia-Initiating Cells and Predicts Poor Prognosis in Acute Myeloid Leukemia
Maria de Grandis
,
Florence Bardin
,
Cyril Fauriat
,
Christophe Zemmour
,
Abdessamad El-Kaoutari
Journal articles
hal-01789603v1
|
|
Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
Thomas Farge
,
Estelle Saland
,
Fabienne de Toni
,
Nesrine Aroua
,
Mohsen Hosseini
Journal articles
inserm-02465205v1
|
|
Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer
M. M-Rabet
,
O. Cabaud
,
E. Josselin
,
P. Finetti
,
R. Castellano
Journal articles
hal-01787533v1
|
|
BTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia.
Audrey Benyamine
,
A. Le Roy
,
Emilie Mamessier
,
J. Gertner-Dardenne
,
C. Castanier
Journal articles
inserm-01416288v1
|
|
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer
Tania M. Puvirajesinghe
,
François Bertucci
,
Ashish Jain
,
Pierluigi Scerbo
,
Edwige Belotti
Journal articles
hal-01447570v1
|
|
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins
Brigitt Raux
,
Yuliia Voitovich
,
Carine Derviaux
,
Adrien Lugari
,
Etienne Rebuffet
Journal articles
hal-01439086v1
|
|
Protein-Protein Interaction Inhibition (2P21)-Oriented Chemical Library Accelerates Hit Discovery
Sabine Milhas
,
Brigitt Raux
,
Stéphane Betzi
,
Carine Derviaux
,
Philippe Roche
Journal articles
hal-01439116v1
|
|
Drug response profiling can predict response to ponatinib in a patient with t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia
Y Collette
,
Thomas Prébet
,
A. Goubard
,
José Adelaïde
,
R Castellano
Journal articles
hal-01218497v1
|
|
A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia
E Saland
,
H Boutzen
,
R Castellano
,
L Pouyet
,
E Griessinger
Journal articles
hal-01219119v1
|
|
A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells
Amelie Fouque
,
Olivier Delalande
,
Mickael Jean
,
Remy Castellano
,
Emmanuelle Josselin
Journal articles
hal-01187307v1
|
|
Accelerating small compounds discovery targeting protein-protein interaction
S. Milhas
,
S. Betzi
,
P. Roche
,
M. Cholay
,
A. Restouin
FEBS Journal, 2015, 282 (1, SI), pp.134
Journal articles
hal-01439038v1
|
|
The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression
Marion A. Salvador
,
Julien Wicinski
,
Olivier Cabaud
,
Yves Toiron
,
Pascal Finetti
Journal articles
hal-01431936v1
|
|
CD95L cell surface cleavage triggers a pro-metastatic signaling pathway in triple negative breast cancer.
Marine Malleter
,
Sebastien Tauzin
,
Alban Bessede
,
Remy Castellano
,
Armelle Goubard
Journal articles
hal-00873634v1
|
|
Stereoselective synthesis of original spirolactams displaying promising folded structures.
Guilhem Chaubet
,
Thibault Coursindel
,
Xavier Morelli
,
Stéphane Betzi
,
Philippe Roche
Journal articles
hal-00871067v1
|
|
Human V 9V 2 T Cells Specifically Recognize and Kill Acute Myeloid Leukemic Blasts
J. Gertner-Dardenne
,
R. Castellano
,
Emilie Mamessier
,
S. Garbit
,
E. Kochbati
Journal articles
hal-01765650v1
|
|
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
Xiaoli Shi
,
Stéphane Betzi
,
Adrien Lugari
,
Sandrine Opi
,
Audrey Restouin
Journal articles
hal-00717171v1
|
|
Stereoselective ring contraction of 2,5-diketopiperazines : An innovative approach to the synthesis of promising bioactive 5-membered scaffolds
Thilbault Coursindel
,
Audrey Restouin
,
Georges Dewynter
,
Jean Martinez
,
Yves Collette
Journal articles
hal-00599350v1
|
|
Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain and ALG-2-interacting protein X
Xiaoli Shi
,
Sandrine Opi
,
Adrien Lugari
,
Audrey Restouin
,
Thibault Coursindel
Journal articles
hal-00600207v1
|
|
Identification and biophysical assessment of the molecular recognition mechanisms between the human hemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X
Xiaoli Shi
,
Sandrine Opi
,
Adrien Lugari
,
Audrey Restouin
,
Thibault Coursindel
Journal articles
hal-00517249v1
|
|
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.
Sophie Reuse
,
Miriam Calao
,
Kabamba Kabeya
,
Allan Guiguen
,
Jean-Stéphane Gatot
Journal articles
hal-00464770v1
|
|
Amine guanidine switch : a promising approach to improve DNA binding and antiproliferative activities.
K. Ohara
,
M. Smietana
,
A. Restouin
,
S. Mollard
,
J.-P. Borg
Journal articles
hal-00346603v1
|
|
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.
Stéphane Betzi
,
Audrey Restouin
,
Sandrine Opi
,
Stefan T Arold
,
Isabelle Parrot
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (49), pp.19256-61. ⟨10.1073/pnas.0707130104⟩
Journal articles
hal-00473817v1
|
|
Parameters involved in the recognition of fresh human leukemic blasts by tumor-specific cytolytic T cell clones: a model study
Hervé Chambost
,
Yves Collette
,
Hélène Dutartre
,
Isabelle Thuret
,
Daniel Olive
Journal articles
hal-02459277v1
|
|
Full Peptide Synthesis, Purification, and Characterization of Six Tat Variants
Jean-Marie Peloponese
,
Yves Collette
,
Catherine Grégoire
,
Christian Bailly
,
Daniel Campèse
Journal articles
hal-02137983v1
|
|
Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.
A Greenway
,
H Dutartre
,
K Allen
,
D Mcphee
,
D Olive
Journal of Virology, 1999, 73 (7), pp.6152-8
Journal articles
hal-02459367v1
|
|
Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway.
G Zauli
,
D Gibellini
,
P Secchiero
,
H Dutartre
,
D Olive
Blood, 1999, 93 (3), pp.1000-10
Journal articles
hal-02459371v1
|
|
The Human Immunodeficiency Virus Type 1 NEF Protein Binds the Src-Related Tyrosine Kinase Lck SH2 Domain Through a Novel Phosphotyrosine Independent Mechanism
Hélène Dutartre
,
Mark Harris
,
Daniel Olive
,
Yves Collette
Journal articles
hal-02459372v1
|
|
The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck
Y. Collette
,
H. Dutartre
,
A. Benziane
,
D. Olive
Journal articles
hal-02459374v1
|
|
Similarity between Nef of primate lentiviruses and p15E of murine and feline leukaemia viruses
Y. Collette
,
H. Dutartre
,
A. Benziane
,
D. Olive
,
V. Collette
Journal articles
hal-02459381v1
|