yves collette

63
Documents
Affiliation actuelle
  • Centre de Recherche en Cancérologie de Marseille (CRCM)
Identifiants chercheurs

Présentation

CRCM (INSERM, AMU, Institut Paoli calmettes, CNRS)

Publications

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Publications

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Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML

Lise Brault , Edwige Voisset , Mathieu Desaunay , Antonia Boudet , Paraskevi Kousteridou et al.

EMBO Molecular Medicine, 2025, 17 (10), pp.2632 - 2660. ⟨10.1038/s44321-025-00296-2⟩

Article dans une revue hal-05344739v1

Dual targeting of CDK6 and LSD1 is synergistic and overcomes differentiation blockade in AML

Lise Brault , Edwige Voisset , Mathieu Desaunay , Antonia Boudet , Paraskevi Kousteridou et al.

EMBO Molecular Medicine, 2025, ⟨10.1038/s44321-025-00296-2⟩

Article dans une revue hal-05267162v1
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ETx-22, a Novel Nectin-4–Directed Antibody–Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4–Expressing Tumors

Marc Lopez , Emerence Crompot , Emmanuelle Josselin , Anne Farina , Marion Rubis et al.

Cancer Research Communications, 2024, 4 (11), pp.2998-3012. ⟨10.1158/2767-9764.CRC-24-0176⟩

Article dans une revue hal-04887527v1
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Venetoclax Resistance in Acute Myeloid Leukemia

Sylvain Garciaz , Marie-Anne Hospital , Yves Collette , Norbert Vey

Cancers, 2024, 16 (6), pp.1091. ⟨10.3390/cancers16061091⟩

Article dans une revue hal-04945122v1

INA03: A Potent Transferrin-Competitive Antibody–Drug Conjugate against CD71 for Safer Acute Leukemia Treatment

Manuela Bratti , Elisa Stubbs , Sergii Kolodych , Herve Souchet , Lois Kelly et al.

Molecular Cancer Therapeutics, 2024, 23 (8), pp.1159-1175. ⟨10.1158/1535-7163.MCT-23-0548⟩

Article dans une revue hal-04887535v1
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From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

Magali Saez-Ayala , Laurent Hoffer , Sébastien Abel , Khaoula Ben Yaala , Benoit Sicard et al.

Nature Communications, 2023, 14 (1), pp.3079. ⟨10.1038/s41467-023-38668-2⟩

Article dans une revue hal-04237671v1

C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3 -Mutant Leukemia

Marie Sabatier , Rudy Birsen , Laura Lauture , Sarah Mouche , Paolo Angelino et al.

Cancer Discovery, 2023, 13 (7), pp.1720-1747. ⟨10.1158/2159-8290.CD-22-0411⟩

Article dans une revue hal-04166110v1
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Niche-expressed Galectin-1 is involved in pre-B acute lymphoblastic leukemia relapse through pre-B cell receptor activation

Jeoffrey Pelletier , Marielle Balzano , Jérôme Destin , Camille Montersino , Marjorie Delahaye et al.

iScience, 2023, 26 (4), pp.106385. ⟨10.1016/j.isci.2023.106385⟩

Article dans une revue hal-04077435v1

Downregulation of stromal syntenin sustains AML development

Raphael Leblanc , Rania Ghossoub , Armelle Goubard , Rémy Castellano , Joanna Fares et al.

EMBO Molecular Medicine, 2023, 15 (11), ⟨10.15252/emmm.202317570⟩

Article dans une revue hal-04532862v1
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CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia

Thomas Farge , Jean Nakhle , Damien Lagarde , Guillaume Cognet , Nathaniel Polley et al.

Cancer Research, 2023, 83 (17), pp.2824-2838. ⟨10.1158/0008-5472.CAN-22-3682⟩

Article dans une revue hal-04282332v1
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CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation

Kendall Carrasco , Camille Montersino , Carine Derviaux , Magali Saez-Ayala , Laurent Hoffer et al.

Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩

Article dans une revue hal-03624836v1
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RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia

Justine Decroocq , Rudy Birsen , Camille Montersino , Prasad Chaskar , Jordi Mano et al.

Leukemia, 2022, 36 (5), pp.1237-1252. ⟨10.1038/s41375-022-01541-0⟩

Article dans une revue hal-04085323v1
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Antimicrobial and cytotoxic effects of marine sponge extracts <i>Agelas clathrodes</i>, <i>Desmapsamma anchorata</i> and <i>Verongula rigida</i> from a Caribbean Island

Julie Piron , Stéphane Betzi , Jessica Pastour , Audrey Restouin , Remy Castellano et al.

PeerJ, 2022, 10, pp.e13955. ⟨10.7717/peerj.13955⟩

Article dans une revue hal-03803766v1
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CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

Françoise Gondois-Rey , Thomas Miller , Vladimir Laletin , Xavier Morelli , Yves Collette et al.

Frontiers in Immunology, 2022, 13, pp.899068. ⟨10.3389/fimmu.2022.899068⟩

Article dans une revue hal-03857250v1
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H3.3K27M Mutation Controls Cell Growth and Resistance to Therapies in Pediatric Glioma Cell Lines

Andria Rakotomalala , Quentin Bailleul , Clara Savary , Mélanie Arcicasa , Maud Hamadou et al.

Cancers, 2021, 13 (21), pp.5551. ⟨10.3390/cancers13215551⟩

Article dans une revue hal-03418323v1

Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell–mediated antitumor immune response

Aude de Gassart , Kieu-Suong Le , Patrick Brune , Sophie Agaugué , Jennifer Sims et al.

Science Translational Medicine, 2021, 13 (616), ⟨10.1126/scitranslmed.abj0835⟩

Article dans une revue inserm-03540734v1
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The NANOTUMOR consortium - Towards the Tumor Cell Atlas

Florent Colin , Kristine Schauer , Ali Hamiche , Pierre Martineau , Jean-Paul Borg et al.

Biology of the Cell, 2021, 113 (6), pp.272-280. ⟨10.1111/boc.202000135⟩

Article dans une revue hal-03169719v1
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Synergy and allostery in ligand binding by HIV-1 Nef

Abdullah Aldehaiman , Afaque A Momin , Audrey Restouin , Luyao Wang , Xiaoli Shi et al.

Biochemical Journal, 2021, 478 (8), pp.1525 - 1545. ⟨10.1042/bcj20201002⟩

Article dans une revue hal-03380308v1
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Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Lucille Stuani , Marie Sabatier , Estelle Saland , Guillaume Cognet , Nathalie Poupin et al.

Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩

Article dans une revue hal-03563454v1

ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells

Florent Amatore , Nicolas Ortonne , Marc Lopez , Florence Orlanducci , Rémy Castellano et al.

Blood Advances, 2020, 4 (20), pp.5203-5214. ⟨10.1182/bloodadvances.2020002395⟩

Article dans une revue hal-03152734v1
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A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study

A. Collignon , M. A Hospital , C. Montersino , F. Courtier , A. Charbonnier et al.

Blood Cancer Journal, 2020, 10 (6), pp.64. ⟨10.1038/s41408-020-0330-5⟩

Article dans une revue inserm-03038330v1
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ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells

Florent Amatore , Nicolas Ortonne , Marc Lopez , Florence Orlanducci , Rémy Castellano et al.

Blood Advances, 2020, 4 (20), pp.5203-5214. ⟨10.1182/bloodadvances.2020002395⟩

Article dans une revue inserm-03038313v1
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A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency

Chantal Lagresle-Peyrou , Aurélien Olichon , Hanem Sadek , Philippe Roche , Claudine Tardy et al.

Haematologica, In press, 106 (2), pp.404-411. ⟨10.3324/haematol.2019.230250⟩

Article dans une revue hal-02545998v1
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In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

Jeremy Ariey‐bonnet , Kendall Carrasco , Marion Le Grand , Laurent Hoffer , Stéphane Betzi et al.

Molecular Oncology, 2020, 14, pp.3083 - 3099. ⟨10.1002/1878-0261.12810⟩

Article dans une revue hal-02989358v1
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Correction: CD95L Cell Surface Cleavage Triggers a Prometastatic Signaling Pathway in Triple-Negative Breast Cancer

Marine Malleter , Sébastien Tauzin , Alban Bessede , Rémy Castellano , Armelle Goubard et al.

Cancer Research, 2020, 80 (3), pp.639-639. ⟨10.1158/0008-5472.CAN-19-3636⟩

Article dans une revue hal-05165942v1

Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells

Amélie Fouqué , Olivier Delalande , Mickael Jean , Rémy Castellano , Emmanuelle Josselin et al.

Journal of Medicinal Chemistry, 2019, 62 (20), pp.9339-9340. ⟨10.1021/acs.jmedchem.9b01578⟩

Article dans une revue hal-02526957v1
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A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells

Abir Arfaoui , Claire Rioualen , Violette Azzoni , Guillaume Pinna , Pascal Finetti et al.

EMBO Molecular Medicine, 2019, 11 (10), pp.e9930. ⟨10.15252/emmm.201809930⟩

Article dans une revue hal-02539524v1
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Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities

Aude Le Roy , Thomas Prebet , Remy Castellano , Armelle Goubard , Florence Riccardi et al.

Frontiers in Immunology, 2018, 9, pp.977. ⟨10.3389/fimmu.2018.00977⟩

Article dans une revue hal-01791593v1
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Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Laurent Hoffer , Yuliia Voitovich , Brigitt Raux , Kendall Carrasco , Christophe Muller et al.

Journal of Medicinal Chemistry, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩

Article dans une revue hal-02067797v1

Cegal Protocol : Evaluation of the Feasibility of a Chemogenomic Approach to Identify Personalized Therapy for Relapse or Refractory AML Patients

Norbert Vey , Marie Anne Hospital , Aude Collignon , Yves Collette , Daniel Birnbaum et al.

Blood, 2018, 132 (1), ⟨10.1182/blood-2018-99-119263⟩

Article dans une revue hal-02143630v1
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Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer

M. M-Rabet , O. Cabaud , E. Josselin , P. Finetti , R. Castellano et al.

Annals of Oncology, 2017, ⟨10.1093/annonc/mdw678⟩

Article dans une revue hal-01787533v1

JAM-C Identifies Src Family Kinase-Activated Leukemia-Initiating Cells and Predicts Poor Prognosis in Acute Myeloid Leukemia

Maria de Grandis , Florence Bardin , Cyril Fauriat , Christophe Zemmour , Abdessamad El-Kaoutari et al.

Cancer Research, 2017, 77 (23), pp.6627-6640. ⟨10.1158/0008-5472.CAN-17-1223⟩

Article dans une revue hal-01789603v1
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Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Thomas Farge , Estelle Saland , Fabienne de Toni , Nesrine Aroua , Mohsen Hosseini et al.

Cancer Discovery, 2017, 7 (7), pp.716-735. ⟨10.1158/2159-8290.cd-16-0441⟩

Article dans une revue inserm-02465205v1
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Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer

Tania M. Puvirajesinghe , François Bertucci , Ashish Jain , Pierluigi Scerbo , Edwige Belotti et al.

Nature Communications, 2016, 7, pp.10318. ⟨10.1038/ncomms10318⟩

Article dans une revue hal-01447570v1

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Brigitt Raux , Yuliia Voitovich , Carine Derviaux , Adrien Lugari , Etienne Rebuffet et al.

Journal of Medicinal Chemistry, 2016, 59 (4, SI), pp.1634-1641. ⟨10.1021/acs.jmedchem.5b01708⟩

Article dans une revue hal-01439086v1

BTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia

Audrey Benyamine , Aude Le Roy , Emilie Mamessier , Julie Gertner-Dardenne , Céline Castanier et al.

OncoImmunology, 2016, 5 (10), pp.e1146843. ⟨10.1080/2162402X.2016.1146843⟩

Article dans une revue hal-03606408v1

Protein-Protein Interaction Inhibition (2P21)-Oriented Chemical Library Accelerates Hit Discovery

Sabine Milhas , Brigitt Raux , Stéphane Betzi , Carine Derviaux , Philippe Roche et al.

ACS Chemical Biology, 2016, 11 (8), pp.2140-2148. ⟨10.1021/acschembio.6b00286⟩

Article dans une revue hal-01439116v1
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Drug response profiling can predict response to ponatinib in a patient with t(1;9)(q24;q34)-associated B-cell acute lymphoblastic leukemia

Y Collette , Thomas Prébet , A. Goubard , José Adelaïde , R Castellano et al.

Blood Cancer Journal, 2015, 5 (e292), ⟨10.1038/bcj.2015.13⟩

Article dans une revue hal-01218497v1

A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells

Amelie Fouque , Olivier Delalande , Mickael Jean , Remy Castellano , Emmanuelle Josselin et al.

Journal of Medicinal Chemistry, 2015, 58 (16), pp.6559-6573. ⟨10.1021/acs.jmedchem.5b00991⟩

Article dans une revue hal-01187307v1
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A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia

E Saland , H Boutzen , R Castellano , L Pouyet , E Griessinger et al.

Blood Cancer Journal, 2015, 5 (e297), ⟨10.1038/bcj.2015.19⟩

Article dans une revue hal-01219119v1

Accelerating small compounds discovery targeting protein-protein interaction

S. Milhas , S. Betzi , P. Roche , M. Cholay , A. Restouin et al.

FEBS Journal, 2015, 282 (1, SI), pp.134

Article dans une revue hal-01439038v1

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392

L. Altucci , F. de Bellis , V. Carafa , M. Conte , D. Rotili et al.

Cancer Research, 2014, 74 (8), pp.2328-39. ⟨10.1158/0008-5472.CAN-13-2568⟩

Article dans une revue hal-03653834v1

CD95L cell surface cleavage triggers a pro-metastatic signaling pathway in triple negative breast cancer.

Marine Malleter , Sebastien Tauzin , Alban Bessede , Remy Castellano , Armelle Goubard et al.

Cancer Research, 2013, 73 (22), pp.6711-21. ⟨10.1158/0008-5472.CAN-13-1794⟩

Article dans une revue hal-00873634v1

The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression

Marion A. Salvador , Julien Wicinski , Olivier Cabaud , Yves Toiron , Pascal Finetti et al.

Clinical Cancer Research, 2013, 19 (23), pp.6520-6531. ⟨10.1158/1078-0432.CCR-13-0877⟩

Article dans une revue hal-01431936v1
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Stereoselective synthesis of original spirolactams displaying promising folded structures.

Guilhem Chaubet , Thibault Coursindel , Xavier Morelli , Stéphane Betzi , Philippe Roche et al.

Organic & Biomolecular Chemistry, 2013, 11 (28), pp.4719-26. ⟨10.1039/c3ob40643a⟩

Article dans une revue hal-00871067v1
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Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

Xiaoli Shi , Stéphane Betzi , Adrien Lugari , Sandrine Opi , Audrey Restouin et al.

FEBS Letters, 2012, 586, pp.1759-1764. ⟨10.1016/j.febslet.2012.05.017⟩

Article dans une revue hal-00717171v1

Human V 9V 2 T Cells Specifically Recognize and Kill Acute Myeloid Leukemic Blasts

J. Gertner-Dardenne , R. Castellano , Emilie Mamessier , S. Garbit , E. Kochbati et al.

Journal of Immunology, 2012, 188 (9), pp.4701 - 4708. ⟨10.4049/jimmunol.1103710⟩

Article dans une revue hal-01765650v1

Stereoselective ring contraction of 2,5-diketopiperazines : An innovative approach to the synthesis of promising bioactive 5-membered scaffolds

Thilbault Coursindel , Audrey Restouin , Georges Dewynter , Jean Martinez , Yves Collette et al.

Bioorganic Chemistry, 2010, 38, pp.210-217. ⟨10.1016/j.bioorg.2010.05.002⟩

Article dans une revue istex hal-00599350v1
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Identification and biophysical assessment of the molecular recognition mechanisms between the human hemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

Xiaoli Shi , Sandrine Opi , Adrien Lugari , Audrey Restouin , Thibault Coursindel et al.

Biochemical Journal, 2010, 431 (1), pp.93-102. ⟨10.1042/BJ20100314⟩

Article dans une revue hal-00517249v1

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain and ALG-2-interacting protein X

Xiaoli Shi , Sandrine Opi , Adrien Lugari , Audrey Restouin , Thibault Coursindel et al.

Biochemical Journal, 2010, 431, pp.93-102. ⟨10.1042/BJ20100314⟩

Article dans une revue hal-00600207v1
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Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Sophie Reuse , Miriam Calao , Kabamba Kabeya , Allan Guiguen , Jean-Stéphane Gatot et al.

PLoS ONE, 2009, 4 (6), pp.e6093. ⟨10.1371/journal.pone.0006093⟩

Article dans une revue hal-00464770v1

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Stéphane Betzi , Audrey Restouin , Sandrine Opi , Stefan T Arold , Isabelle Parrot et al.

Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (49), pp.19256-61. ⟨10.1073/pnas.0707130104⟩

Article dans une revue hal-00473817v1

Amine guanidine switch : a promising approach to improve DNA binding and antiproliferative activities.

K. Ohara , M. Smietana , A. Restouin , S. Mollard , J.-P. Borg et al.

Journal of Medicinal Chemistry, 2007, 50, pp.6465-6475. ⟨10.1021/jm701207m⟩

Article dans une revue hal-00346603v1

Parameters involved in the recognition of fresh human leukemic blasts by tumor-specific cytolytic T cell clones: a model study

Hervé Chambost , Yves Collette , Hélène Dutartre , Isabelle Thuret , Daniel Olive

Leukemia Research, 2000, 24 (10), pp.823-830. ⟨10.1016/s0145-2126(00)00053-9⟩

Article dans une revue istex hal-02459277v1

Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.

A Greenway , H Dutartre , K Allen , D Mcphee , D Olive et al.

Journal of Virology, 1999, 73 (7), pp.6152-8

Article dans une revue hal-02459367v1

Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway.

G Zauli , D Gibellini , P Secchiero , H Dutartre , D Olive et al.

Blood, 1999, 93 (3), pp.1000-10

Article dans une revue hal-02459371v1

Full Peptide Synthesis, Purification, and Characterization of Six Tat Variants

Jean-Marie Peloponese , Yves Collette , Catherine Grégoire , Christian Bailly , Daniel Campèse et al.

Journal of Biological Chemistry, 1999, 274 (17), pp.11473-11478. ⟨10.1074/jbc.274.17.11473⟩

Article dans une revue hal-02137983v1

The Human Immunodeficiency Virus Type 1 NEF Protein Binds the Src-Related Tyrosine Kinase Lck SH2 Domain Through a Novel Phosphotyrosine Independent Mechanism

Hélène Dutartre , Mark Harris , Daniel Olive , Yves Collette

Virology, 1998, 247 (2), pp.200-211. ⟨10.1006/viro.1998.9244⟩

Article dans une revue hal-02459372v1

The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck

Y. Collette , H. Dutartre , A. Benziane , D. Olive

Research in virology, 1997, 148 (1), pp.52-58. ⟨10.1016/s0923-2516(97)81914-0⟩

Article dans une revue istex hal-02459374v1

Similarity between Nef of primate lentiviruses and p15E of murine and feline leukaemia viruses

Y. Collette , H. Dutartre , A. Benziane , D. Olive , V. Collette

AIDS. Official journal of the international AIDS Society, 1996, 10 (4), pp.441. ⟨10.1097/00002030-199604000-00013⟩

Article dans une revue hal-02459381v1

On Object-Oriented Programming of Optimizers - Examples in Scilab

Y. Collette , Nikolaus Hansen , Gilles Pujol , Daniel Salazar Aponte , Rodolphe Le Riche

Rajan Filomeno Coelho and Piotr Breitkopf. Multidisciplinary Design Optimization in Computational Mechanics, Wiley, pp. 499-538, 2010

Chapitre d'ouvrage inria-00476172v1