ZUZANA MACEK JILKOVA

43
Documents
Affiliations actuelles
  • Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB)
  • Service d'hépato-gastroentérologie [CHU Grenoble Alpes]
  • Dynamique cellulaire, Immunité, Métabolisme & Cancer/Cell Dynamics, Immunity, Metabolism & Cancer (DIMAC - IAB)
  • Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA)
Identifiants chercheurs

Publications

Publications

Intratumoral PD-1high CD8+ T cells correlate with AFP levels in HCC patients: a brief report

Zuzana Macek Jilkova , Julien Ghelfi , Lucile Dumolard , Christian Sengel , Bleuenn Brusset et al.

Cellular Oncology, 2026, 49 (1), pp.39. ⟨10.1007/s13402-026-01170-0⟩

Article dans une revue hal-05509807v1

New Insights into Antibody-Mediated NK Cell Immunity in Hepatitis B: Editorial on "Dissecting antibody-mediated NK cell effects reveals a cytotoxic CX3CR1⁺KLRC2⁻CD16hi subset linked to HBV outcomes

Zuzana Macek Jilkova , Caroline Aspord

Clinical and molecular hepatology, 2026, ⟨10.3350/cmh.2026.0025⟩

Article dans une revue hal-05509830v1

Identification of immunogenic HLA-A*02:01 epitopes associated with HCC for immunotherapy development

Anthony Maino , Thomas Decaens , Saadi Khochbin , Zuzana Macek Jilkova , Sophie Rousseaux et al.

Hepatology Communications, 2025, 9 (3), ⟨10.1097/HC9.0000000000000659⟩

Article dans une revue hal-05004966v1

Metabolic dysregulation in regulatory T cells from patients with immune-mediated glomerular diseases

Johan Noble , Zuzana Macek-Jilkova , Philippe Saas , Paolo Malvezzi , Miguel Fribourg et al.

Journal of Nephrology, 2025, ⟨10.1007/s40620-025-02306-5⟩

Article dans une revue hal-05105426v1
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HBV and HBsAg strongly reshape the phenotype, function, and metabolism of DCs according to patients’ clinical stage

Lucile Dumolard , Theophile Gerster , Florent Chuffart , Thomas Decaens , Marie-Noelle Hilleret et al.

Hepatology Communications, 2025, 9 (2), pp.276-284. ⟨10.1097/HC9.0000000000000625⟩

Article dans une revue hal-04940822v1
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PD1 and TIM3 Expression is Associated with Very Early Hepatocellular Carcinoma Recurrence After Percutaneous Thermal Ablation

Julien Ghelfi , Zuzana Macek Jilkova , Christian Sengel , Bleuenn Brusset , Yann Teyssier et al.

Journal of Hepatocellular Carcinoma, 2024, 11, pp.39 - 50. ⟨10.2147/jhc.s443134⟩

Article dans une revue hal-05006680v1
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Liver cancer in ovo models for preclinical testing

Paul Garcia , Yan Wang , Jean Viallet , Nour El Houda Mehdi , Emilie Montaut et al.

FASEB Journal, 2024, 38 (17), pp.e70029. ⟨10.1096/fj.202401416R⟩

Article dans une revue hal-05003857v1
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Hepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors

Charlotte Hernandez , Claire Verzeroli , Armando Andres Roca Suarez , Abud Jose Farca Luna , Laurie Tonon et al.

JHEP Reports Innovation in Hepatology, 2024, 7 (1), pp.101245. ⟨10.1016/j.jhepr.2024.101245⟩

Article dans une revue hal-04876113v1
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Role of Genetic and Epigenetic Modifications in the Progression of Hepatocellular Carcinoma in Chronic HCV Patients

Anum Syyam , Hira Raheem Akbar , Zuzana Macek Jilkova , Samia Afzal

Livers, 2023, 3 (1), pp.82-92. ⟨10.3390/livers3010008⟩

Article dans une revue (article de synthèse) hal-05007165v1
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Intracellular accumulation and immunological response of NIR-II polymeric nanoparticles

Iryna Moskalevska , Virginie Faure , Lucie Haye , Marion Mercey-Ressejac , Arindam Dey et al.

International Journal of Pharmaceutics, 2023, 630, pp.122439. ⟨10.1016/j.ijpharm.2022.122439⟩

Article dans une revue hal-03972922v1
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Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet

Domenico Iuso , Isabel Garcia-Saez , Yohann Couté , Yoshiki Yamaryo-Botté , Elisabetta Boeri Erba et al.

Science Advances , 2023, 9 (36), pp.eadh0140. ⟨10.1126/sciadv.adh0140⟩

Article dans une revue hal-04216158v1
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Enantioselective approach for expanding the three‐dimensional space of tetrahydroquinoline to develop bet bromodomain inhibitors

Marie‐ange Lespinasse , Kaiyao Wei , Justine Perrin , Matthias Winkler , Sieme Hamaidia et al.

Chemistry - A European Journal, 2022, 28 (64), pp.e202202293. ⟨10.1002/chem.202202293⟩

Article dans une revue hal-03806738v1
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Effect of Novel AKT Inhibitor Vevorisertib as Single Agent and in Combination with Sorafenib on Hepatocellular Carcinoma in a Cirrhotic Rat Model

Keerthi Kurma , Ayca Zeybek Kuyucu , Gaël Roth , Nathalie Sturm , Marion Mercey-Ressejac et al.

International Journal of Molecular Sciences, 2022, 23 (24), pp.16206. ⟨10.3390/ijms232416206⟩

Article dans une revue hal-04651076v1
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Chronic Intermittent Hypoxia Increases Cell Proliferation in Hepatocellular Carcinoma

Lydie Carreres , Marion Mercey-Ressejac , Keerthi Kurma , Julien Ghelfi , Carole Fournier et al.

Cells, 2022, 11 (13), pp.2051. ⟨10.3390/cells11132051⟩

Article dans une revue hal-04649799v1

Gamma delta T cells in hepatocellular carcinoma: Sunrise of new therapy based on Vδ2 T cells?

Zuzana Macek Jilkova

Clinical and Translational Medicine, 2022, 12 (4), ⟨10.1002/ctm2.834⟩

Article dans une revue hal-05007097v1
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Modeling Diet-Induced NAFLD and NASH in Rats: A Comprehensive Review

Lydie Carreres , Zuzana Macek Jílková , Guillaume Vial , Patrice N. Marche , Thomas Decaens et al.

Biomedicines, 2021, 9 (4), pp.378. ⟨10.3390/biomedicines9040378⟩

Article dans une revue inserm-03655112v1

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister , Nicolás Gonzalo Núñez , Roser Pinyol , Olivier Govaere , Matthias Pinter et al.

Nature, 2021, 592 (7854), pp.450-456. ⟨10.1038/s41586-021-03362-0⟩

Article dans une revue hal-03258586v1

Increased Intrahepatic Expression of Immune Checkpoint Molecules in Autoimmune Liver Disease

Zuzana Macek Jilkova , Marie Noelle Hilleret , Theophile Gerster , Nathalie Sturm , Marion Mercey-Ressejac et al.

Cells, 2021, 10 (10), pp.2671. ⟨10.3390/cells10102671⟩

Article dans une revue hal-05006859v1
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GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer

Sonia Brun , Jean-Marc Pascussi , Elena Patricia Gifu , Eloïne Bestion , Zuzana Macek-Jilkova et al.

American Journal of Cancer, 2021, 12 (18), pp.5432-5438. ⟨10.7150/jca.58533⟩

Article dans une revue hal-03326462v1
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NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister , Nicolás Gonzalo Núñez , Roser Pinyol , Olivier Govaere , Matthias Pinter et al.

Nature, 2021, 592 (7854), pp.450-456. ⟨10.1038/s41586-021-03362-0⟩

Article dans une revue inserm-03348110v1
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GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

Sonia Brun , Eloïne Bestion , Eric Raymond , Firas Bassissi , Zuzana Macek Jilkova et al.

Autophagy, 2021, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩

Article dans une revue (data paper) hal-04876759v1
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Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment

Mariam Mroweh , Gaël Roth , Thomas Decaens , Patrice Marche , Hervé Lerat et al.

International Journal of Molecular Sciences, 2021, 22 (4), pp.1794. ⟨10.3390/ijms22041794⟩

Article dans une revue inserm-03348116v1

Predictive Factors for Hepatocellular Carcinoma Development after Direct-Acting Antiviral Treatment of HCV

Zuzana Macek Jilkova , Komal Saleem , Samia Afzal , Thomas Decaens

Livers, 2021, 1 (4), pp.313-321. ⟨10.3390/livers1040024⟩

Article dans une revue hal-05006799v1
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DEN-Induced Rat Model Reproduces Key Features of Human Hepatocellular Carcinoma

Keerthi Kurma , Olivier Manches , Florent Chuffart , Nathalie Sturm , Khaldoun Gharzeddine et al.

Cancers, 2021, 13 (19), pp.4981. ⟨10.3390/cancers13194981⟩

Article dans une revue hal-04649803v1
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Circulating IL-13 Is Associated with De Novo Development of HCC in HCV-Infected Patients Responding to Direct-Acting Antivirals

Zuzana Macek Jílková , Arnaud Seigneurin , Celine Coppard , Laurissa Ouaguia , Caroline Aspord et al.

Cancers, 2020, 12 (12), pp.3820. ⟨10.3390/cancers12123820⟩

Article dans une revue hal-05007125v1
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Percutaneous Ablation-Induced Immunomodulation in Hepatocellular Carcinoma

Lucile Dumolard , Julien Ghelfi , Gael Roth , Thomas Decaens , Zuzana Macek Jilkova

International Journal of Molecular Sciences, 2020, 21 (12), pp.4398. ⟨10.3390/ijms21124398⟩

Article dans une revue (article de synthèse) hal-05006882v1
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Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma

Mariam Mroweh , Thomas Decaens , Patrice Marche , Zuzana Macek Jilkova , Flora Clément

International Journal of Molecular Sciences, 2020, 21 (15), pp.5250. ⟨10.3390/ijms21155250⟩

Article dans une revue inserm-03348119v1
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GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Eloïne Bestion , Zuzana Macek Jilkova , Jean-Louis Mège , Marie Novello , Keerthi Kurma et al.

Therapeutic Advances in Chronic Disease, 2020, 11, pp.204062232094204. ⟨10.1177/2040622320942042⟩

Article dans une revue hal-03677273v1
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Reply to Comment on “Jilkova, Z.M.; et al. Predictive Factors for Response to PD-1/PD-L1 Checkpoint Inhibition in the Field of Hepatocellular Carcinoma: Current Status and Challenges” Cancers 2019, 11, 1554

Zuzana Macek Jilkova , Caroline Aspord , Thomas Decaens

Cancers, 2020, 12 (9), pp.2673. ⟨10.3390/cancers12092673⟩

Article dans une revue inserm-05005566v1
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Immunologic Features of Patients With Advanced Hepatocellular Carcinoma Before and During Sorafenib or Anti-programmed Death-1/Programmed Death-L1 Treatment

Zuzana Macek Jilkova , Caroline Aspord , Keerthi Kurma , Anouck Granon , Christian Sengel et al.

Clinical and translational gastroenterology, 2019, 10 (7), pp.e00058. ⟨10.14309/ctg.0000000000000058⟩

Article dans une revue inserm-02332361v1
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Animal Models of Hepatocellular Carcinoma: The Role of Immune System and Tumor Microenvironment

Zuzana Macek Jilkova , Keerthi Kurma , Thomas Decaens

Cancers, 2019, 11 (10), pp.1487. ⟨10.3390/cancers11101487⟩

Article dans une revue (article de synthèse) hal-05006948v1
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Predictive Factors for Response to PD-1/PD-L1 Checkpoint Inhibition in the Field of Hepatocellular Carcinoma: Current Status and Challenges

Zuzana Macek Jilkova , Thomas Decaens , Caroline Aspord

Cancers, 2019, 11 (10), pp.1554. ⟨10.3390/cancers11101554⟩

Article dans une revue (article de synthèse) hal-05006940v1
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Combination of AKT inhibitor ARQ 092 and sorafenib potentiates inhibition of tumor progression in cirrhotic rat model of hepatocellular carcinoma

Zuzana Macek Jilkova , Ayca Zeybek Kuyucu , Keerthi Kurma , Ahmad Pour , Gaël S Roth et al.

Oncotarget, 2018, 9 (13), pp.11145-11158. ⟨10.18632/oncotarget.24298⟩

Article dans une revue inserm-02332894v1
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Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels

Zuzana Macek Jilkova , Thomas Decaens , Alice Marlu , Hélène Marche , Evelyne Jouvin-Marche et al.

Mediators of Inflammation, 2017, 2017, pp.1-5. ⟨10.1155/2017/3214917⟩

Article dans une revue inserm-02333383v1
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Progression of fibrosis in patients with chronic viral hepatitis is associated with IL-17 + neutrophils

Zuzana Macek Jilkova , Samia Afzal , Hélène Marche , Thomas Decaens , Nathalie Sturm et al.

Liver International, 2016, 36 (8), pp.1116-24. ⟨10.1111/liv.13060⟩

Article dans une revue inserm-02333978v1
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CCM proteins control endothelial b1 integrin dependent response to shear stress

Zuzana Macek Jilkova , Justyna Lisowska , Sandra Manet , Claude Verdier , Valerie Deplano et al.

Biology Open, 2014, 3 (12), pp.1228-1235. ⟨10.1242/bio.201410132⟩

Article dans une revue hal-01096964v1
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Wall shear stress and endothelial cells dysfunction in the context of abdominal aortic aneurysms

Zuzana Macek Jilkova , Valérie Deplano , Claude Verdier , Mamadou Toungara , Christian Geindreau et al.

Computer Methods in Biomechanics and Biomedical Engineering, 2013, 16 (supp1), pp.27-29. ⟨10.1080/10255842.2013.815959⟩

Article dans une revue hal-00853100v1
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The inhibition of fat cell proliferation by n-3 fatty acids in dietary obese mice

Michal Hensler , Kristina Bardova , Zuzana Macek Jílková , Walter Wahli , Daniel Metzger et al.

Lipids in Health and Disease, 2011, 10 (1), pp.128. ⟨10.1186/1476-511X-10-128⟩

Article dans une revue hal-04977181v1

Greener Pharmaceuticals: Short and Modular Enantioselective Organocatalyzed Synthesis of new BET Bromodomain Inhibitors with Anti-inflammatory Action

Yung-Sing Wong , Marie‐ange Lespinasse , Kaiyao Wei , Julien Perrin , Matthias Winkler et al.

8th EuChemS Chemistry Congress, EuChemS, Aug 2022, Lisbon (Portugal), Portugal

Communication dans un congrès hal-04776762v1

GNS561, A NEW LYSOSOMOTROPIC SMALL MOLECULE, FOR THE TREATMENT OF LIVER FIBROSIS

Bestion, Eloine , Gilles Lalmanach , Marie Novello , Zuzana Macek Jilkova , Firas Bassissi et al.

Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Nov 2019, Boston, MA, United States. pp.1268A-1269A

Communication dans un congrès hal-02466561v1